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Bacteria Made to Behave as Computers

hende_jman writes "Scientists at Princeton University successfully 'programmed bacteria to behave like computers, assembling themselves into complex shapes based on instructions stuffed into their genes.' Though applications may not come for awhile, the article says that in the future this technology may be used in devices to detect bioterrorism chemicals. The article also has pictures of the programmed E. coli."

21 of 303 comments (clear)

  1. Call me cynical... by Anonymous Coward · · Score: 4, Insightful

    Though applications may not come for awhile, the article says that in the future this technology may be used in devices to detect bioterrorism chemicals.

    Call me cynical, but I think this technology will be used in devices to make and control bioterrorism chemicals. And not necessarily by the "bad guys" either.

  2. New Programming language by hattan · · Score: 5, Funny

    Bacteria.NET Sharp

  3. swell... by ErichTheWebGuy · · Score: 4, Funny

    First, they made armed autonomous robots, now it's smart bacteria that is potentially deadly... All that remains now is for the two to team up against their human opressors. I feel good about it.

    --
    bash: rtfm: command not found
    1. Re:swell... by rakeswell · · Score: 5, Insightful

      Well, someone yesterday made a comment about when they were in school, they were exhorted to list in their papers any military applications the technology might have in order to ensure securing additional research funding, etc. That was the first thing I thought of when I read "...this technology may be used in devices to detect bioterrorism chemicals."

      Sounds we'll be seeing a lot of technology with terrorism-fighting potential for a while to come.

      --
      All one has to do is hit the right keys at the right time and the instrument plays itself. - Johann Sebastian Bach
  4. Imagine... by robpoe · · Score: 5, Funny

    A Beow ... nevermind .. screw it..

    I for one wel... naw, screw it

    In Soviet Russia .. The bacter... laaaaame

    the GN... err .. nevermind

    Hmmm..

    --
    = Grow a brain...
    1. Re:Imagine... by Dead+Kitty · · Score: 4, Funny

      A Beow ... nevermind .. screw it..

      Can you imagine a culture of these things?

  5. Them bugs.. by ackthpt · · Score: 4, Funny
    "Is that the old Life simulation?"

    "No, it's a diagnostic."

    --

    A feeling of having made the same mistake before: Deja Foobar
  6. Blood Music? by Scud · · Score: 4, Interesting

    Anybody else have visions of the Greg Bear book "Blood Music" when you read this?

    http://www.allscifi.com/Topics/info_5673.asp?BSID= 17562821

    --
    I dream in binary.
  7. Virus by AFairlyNormalPerson · · Score: 4, Interesting

    All they need to do now is do this to a virus... then maybe we can give the virus a virus. Kinda funny, but it would be cool if it led to the desctuction of aids.

    1. Re:Virus by zbyte64 · · Score: 5, Insightful

      Here's the flaw with that simple idea:

      Viruses are simply encapsulated DNA with simple crap - they don't manufacture anything. Instead they use other cells to manufacture more of themselves. So a Virus for a Virus would mean for every bad virus in your system, you would need one anti manufactured. Anyevent, now if u had engineered bacteria that i guess would be the equivilant of a "honeypot" in that a viral latches on, but the engineered bacteria destroys incomming DNA etc. But then that would mean the bacteria would be very resistant to various forms of genetic therapy. Just imagine what would happen if the bacteria grew out of control (they need a food source), or mutated into something rlly bad. Do i need to elaborate?

      Anyways, im more worried about new bacteria that is now resistant to antibacterial soap and such. Many of those strains are friggen hard to kill. Granted i could imagine engineering bacteria to kill this.

      I know im just rambling on here, so lemme just sum up what would probably needed to be done to help ensure this new disease fighting bacteria doesn't become our worse nightmare:
      Engineered life cycle, ie a counter for how many times the bacteria can reproduce
      Possible activating agent? Have these bacteria only work if a certain protein is present, etc
      Deactivating agent - simply again, something innate that can be introduced into the blood stream that would cause the bacteria to dismantle itself.
      The odds of the bacteria mutating such that the life cycle and the deactivating agent is ignored before the life cycle is expired would hopefully be enough. Then also consider your body's natural immune system,

      I have no clue how long it would be before bioengineers can do all this, but it is most exiciting

  8. Awesome by dirtsurfer · · Score: 5, Funny

    It's amazing how you can control an organism's behavoir by altering it's DNA.

    *yawn* Welp, time to go look at pictures of naked girls.

  9. Bacteria + Windows = Nightmare by jordie · · Score: 5, Funny

    I can only imagine what wonderful ideas Micro$oft is coming up with right now... Imagine your 'computer' crashing and growing all over your house.

  10. Wired Article by Brendor · · Score: 4, Informative

    Wired did an article about a similar notion back in 1995 which was rather interesting at the time.

  11. I FOUND by NoGuffCheck · · Score: 5, Funny

    a betterpictureof bacteria assembling themselves into complex shapes based on instructions stuffed into their genes

    --
    serenity now!
  12. This explains a lot by 3770 · · Score: 4, Funny

    This explains why I could calculate PI to 1 000 000 decimals in 1.8 seconds the last time I was sick.

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    The Internet is full. Go Away!!!
  13. Re:e coli inside by SidV · · Score: 4, Funny

    What to go with your piece of sh*t car. ;)

  14. First program: by goombah99 · · Score: 5, Funny

    Perhaps the first program will be a cellular Autonoma simmulation. They could program it to play the game of Life.

    --
    Some drink at the fountain of knowledge. Others just gargle.
  15. Re:Prey? by Spy+Hunter · · Score: 4, Interesting
    Anyone else read "Prey" by Micheal Crichton?

    Yeah, and I feel stupider just for having done so. It reads like a bad novelization of a "major motion picture". As I read the book, I could just see Crichton sitting there thinking "OK, now I'll write in a couple cool CG special-effects shots for the movie".

    I hear the movie deal was done before the book even came out. Unfortunately the plot and characters were overlooked, there's not a shred of originality in the whole thing. And the science doesn't even bear talking about.

    I liked Jurassic Park, and Sphere was awesome, but his latest stuff is just trash. Crichton should just admit he knows very little about real science and go back to writing enjoyable science fiction that doesn't pretend to be a commentary on society's faith in technology and the scientific community.

    --
    main(c,r){for(r=32;r;) printf(++c>31?c=!r--,"\n":c<r?" ":~c&r?" `":" #");}
  16. nice comparison by Dr.Opveter · · Score: 4, Funny
    Bacteria have been programmed to behave like computers, assembling themselves into complex shapes based on instructions stuffed into their genes.

    The last time i saw a computer assembling itself into a complex shape it didn't need instructions to accomplish that. Gravity is pretty much all it took.

    --
    Sample this!
  17. Relevant research publications by FleaPlus · · Score: 4, Informative

    ::digs around for relevant info::

    First off, here's the web page for Ron Weiss, the scientist mentioned in the article.

    Here's (what I think is) the relevant publication on the topic:

    A synthetic multicellular system for programmed pattern formation

    Subhayu Basu, Yoram Gerchman, Cynthia H. Collins, Frances H. Arnold and Ron Weiss

    Nature 434, 1130-1134 (28 April 2005)

    Pattern formation is a hallmark of coordinated cell behaviour in both single and multicellular organisms1, 2, 3. It typically involves cellcell communication and intracellular signal processing. Here we show a synthetic multicellular system in which genetically engineered 'receiver' cells are programmed to form ring-like patterns of differentiation based on chemical gradients of an acyl-homoserine lactone (AHL) signal that is synthesized by 'sender' cells. In receiver cells, 'band-detect' gene networks respond to user-defined ranges of AHL concentrations. By fusing different fluorescent proteins as outputs of network variants, an initially undifferentiated 'lawn' of receivers is engineered to form a bullseye pattern around a sender colony. Other patterns, such as ellipses and clovers, are achieved by placing senders in different configurations. Experimental and theoretical analyses reveal which kinetic parameters most significantly affect ring development over time. Construction and study of such synthetic multicellular systems can improve our quantitative understanding of naturally occurring developmental processes and may foster applications in tissue engineering, biomaterial fabrication and biosensing.


    This conference abstract is also pretty darned cool:

    Dynamic Control in a Coordinated Multi-Cellular Maze Solving System

    Hsu, Allen (Princeton Univ.), Vijayan, Vikram (Princeton Univ.), Fomundam, Lawrence (Univ. of Maryland, Baltimore County), Gerchman, Yoram (Princeton Univ.), Basu, Subhayu (Princeton Univ.), Karig, David (Princeton Univ.), Hooshangi, Sara (Princeton Univ.), Weiss, Ron (Princeton Univ.)

    2005 American Control Conference

    Control system theory provides convenient tools and concepts for describing and analyzing complex cell functions. In this paper we demonstrate the use of control theory to forward-engineer a complex synthetic gene network constructed from several modular components. Specifically, we present the design and simulation of a synthetic multi-cellular maze-solving system. Here, bacterial cells are programmed to use artificial cell-to-cell communication and regulatory feedback in order to illuminate the correct path in a user-defined maze of cells arranged on a surface. Simulations were used to analyze the system's spatiotemporal dynamics and sensitivity to various kinetic parameters. Experiments with Escherichia coli were carried out to characterize the diffusion properties of artificial cell-to-cell communication based on bacterial quorum sensing systems. The rational design process and simulation tools employed in this study provide an example for future engineering of complex synthetic gene networks comprising multiple control system motifs.

  18. Re:mod -1 Americ-bashing by tokabola · · Score: 4, Insightful

    The United States of America are very involved in terrorism. Osama Bin Laden was trained in terrorism by the CIA. That's not "tin foil hat" talk, that's a known, admitted-by-the-CIA fact. The U.S. government has also been the force that got Pappa Doc, Manuel Noriega, and the Shah of Iran into power, just to name a few. These are verified, undisputed (by the government - hotly disputed by the "US can do no wrong" crowd) facts, not liberal propaganda. Even in Afghanistan, the Taliban was able to gain control because the people couldn't tolerate the warlords empowered by the CIA to fight the Russians. The same warlords placed back in power during the "liberation" of Afghanistan.

    As for proof, there are plenty of records of this, available from the government itself through the Freedom of Information Act. The government freely admits to doing these things, and use the mistakes they made in the past to justify making the same mistakes again today. "We shouldn't have done that, but now they hate us so we have to kick their butts again" is standard operating procedure. That's not liberal hogwash - that's known fact - undisputed by anyone except a few obsessive nationalists like yourself.

    The US government has sponsored and trained terrorists for over 40 years, all in the name of "peace" and "democracy". I'm not saying this because I hate America, but because I am an American patriot who believes in what the Constitution. The American government has enabled, encouraged, and full on participated in atrocities when ever the powers-that-be have decided it was expedient.

    I don't condone terrorism, no matter who's committing it. But do you really think people would be willing to die just to hurt the US without any reason? Terrorism is the price America pays for it's hubris. While our pride and unrelenting arrogance don't justify terrorism, they are the root cause of it.

    People like you, who throw out logic and compassion in exchange for jingoistic egotism are what is ruining the country I love. You are the people who talk about bringing Democracy to the world when we don't even truly have it in the US. The government brags about bringing "fair and impartial" elections to Iraq, because they can't brag about having them here in the US.

    A true American Patriot follows his own morals, not his president. If your morals align with our current governments, then you are a traitor to the very ideals that are supposed to set us above all the commies and terrorists.

    Tommy

    BTW, I could have just modded you down for trolling, but I don't want people in other counties to think that most of America are as screwed up as you. It seemed more important to let people know that most Americans think you are an asshat. Unfortunately, after two illegal and constitutionally invalid elections most Americans have realized that "the people" no longer run America.
    --
    Open Source for Open Minds