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The Dopamine - Impulse Buy link

cogno64 writes "Certain stimuli in the brain, such as the smell of freshly based cookies, lead to higher levels of dopamine that remain after the stimulus is removed, leading to altered behavior through interaction with learning, memory, and executive function. The experiencer is more likely to make a purchase decision based on their heightened dopamine levels, with significant impact for internet marketers. According to research presented at the Society for Neuroscience Annual Meeting today, the neurotransmitter dopamine continues to be released for nearly an hour after neurons are stimulated, suggesting the existence of secondary mechanisms that allow for sustained availability of dopamine in different regions of the brain including areas critical for memory consolidation, drug induced plasticity and maintaining active networks during working memory. Dopamine is a neurotransmitter associated with learning and memory, motor control, reward perception and executive functions such as working memory, behavioral flexibility and decision making. When a novel or salient stimulus occurs, the dopamine neurons in the brain increase their firing rate, boosting the release of dopamine. The dopamine is diffused into the extracellular space of the brain until it can be transported or metabolized."

85 comments

  1. Computer cases doped in the stuff by LiquidCoooled · · Score: 1

    No longer will you "just" get a cut hand when reaching inside, you will get 2ccs of pure dopamine.
    Not that you would notice with your new Apple mac and 32" monitor.

    --
    liqbase :: faster than paper
    1. Re:Computer cases doped in the stuff by Anonymous Coward · · Score: 1, Interesting

      Not that you would notice your new Apple mac and 32" monitor with 2 cc (1 cc ~= 1 mL with water at STP) of dopamine on board.

      Mesoenteric effects begin as low as 2 mcg/(kg×min), while therapeutic doses generally range 5-20 mcg/(kg×min), where 'mcg' = microgram, since slashcode and medicolegal charting object to mu.

    2. Re:Computer cases doped in the stuff by elviscious · · Score: 1

      Actually, dopamine doesn't pass through the blood/brain barrier, so it would have to shoot you up with l-dopa.

    3. Re:Computer cases doped in the stuff by Anonymous Coward · · Score: 0

      Allow me to optimize:

      Mesoenteric effects begin as low as 2 microgram/(kg×min), while therapeutic doses generally range 5-20 microgram/(kg×min).

  2. Freshly Based Cookies by szembek · · Score: 1

    How does one base a cookie?

    --
    nothing
    1. Re:Freshly Based Cookies by Anonymous Coward · · Score: 2, Funny

      What? You mean you've never freebased freshly baked chocolate chip cookies?

    2. Re:Freshly Based Cookies by beckerist · · Score: 1

      First you grab your BBQ brush and open the jar of turkey fat (making sure not to spill!). Lightly coat the cookies by "painting" the fat onto said cookie, and throw back in the oven!

      Makes for a scrumptious, not-so-easily-digestable treat!

    3. Re:Freshly Based Cookies by ianc7 · · Score: 0

      Very carefully, I'd imagine.

    4. Re:Freshly Based Cookies by Anonymous Coward · · Score: 0

      crumble it up on a spoon with a little milk, light a lighter underneith and inject it into your veins

    5. Re:Freshly Based Cookies by Anonymous Coward · · Score: 0

      I couldn't figure out whether it was "freshly baked cookies" (YUM!) or "free based cookies" (WHOA!).

    6. Re:Freshly Based Cookies by no+reason+to+be+here · · Score: 1

      uhhh...what you described is basting, not basing.

    7. Re:Freshly Based Cookies by fbjon · · Score: 1

      All your cookies are based to us.

      --
      True confidence comes not from realising you are as good as your peers, but that your peers are as bad as you are.
    8. Re:Freshly Based Cookies by beckerist · · Score: 1

      ummm...I knew that!

    9. Re:Freshly Based Cookies by Reziac · · Score: 2, Informative

      An AC says, "What? You mean you've never freebased freshly baked chocolate chip cookies?"

      Certainly I have! Easiest method is to just eat all the dough without bothering to bake it. :)

      --
      ~REZ~ #43301. Who'd fake being me anyway?
    10. Re:Freshly Based Cookies by famikon · · Score: 0

      Not sure, but they all are belong to us.

    11. Re:Freshly Based Cookies by Jorelli · · Score: 1

      ...i thought he said freebase, no?

    12. Re:Freshly Based Cookies by Reziac · · Score: 1

      Well, yeah. You just inhale the cookie dough. No flames needed. :)

      --
      ~REZ~ #43301. Who'd fake being me anyway?
  3. Introducing "Smelzak" by bkeeler · · Score: 2, Interesting

    ...from the same great folks that brought you "Muzak". Step into the elevator and the smell of fresh cinnamon rolls is chemically synthesized and fed into the vents. By the time you arrive in the department store you'll already be reaching for your wallet!

    1. Re:Introducing "Smelzak" by Reverend99 · · Score: 1

      Stores already do this. You'll notice that your major department stores do not smell like defecation.

    2. Re:Introducing "Smelzak" by Ark42 · · Score: 1

      No, most seem to smell overwhelmingly of strong chemical perfumes that border on nauseating. I particularly hate even being within 2 or 3 stores down from wherever the nail salon is in any mall as well.

  4. Smell-o-vision by Daemonstar · · Score: 1
    Certain stimuli in the brain, such as the smell of freshly based cookies, lead to higher levels of dopamine that remain after the stimulus is removed, leading to altered behavior through interaction with learning, memory, and executive function. The experiencer is more likely to make a purchase decision based on their heightened dopamine levels, with significant impact for internet marketers
    So when will we stop focusing so much on video resolution and get smell-o-vision?! Just as long as there's a "smell blocking" function (like mute).

    Waits for the "Smell-o-Scope" and "Uranus/Urectum" jokes to start.
    --
    I don't reply to Anonymous posts; if you have something to say to me, identify yourself or I won't reply.
  5. Oh, crap! by Rob+T+Firefly · · Score: 4, Funny

    But I always eat cookies when browsing Slashdot... hey, that explains the huge pile of overhyped LED keyboards, novelty mice, Futurama DVDs, Phantom lapboards, and iPod accesories in my office!

    1. Re:Oh, crap! by Blakey+Rat · · Score: 1

      I'm calling you out on this one.

      A real life Phantom lapboard? No way in hell!

    2. Re:Oh, crap! by 192939495969798999 · · Score: 1

      yeah, I agree about the Ipod accessories, etc. but remember, LED keyboards are bad ass!

      --
      stuff |
    3. Re:Oh, crap! by nizo · · Score: 4, Funny

      And we see yet another reason to browse with cookies turned off.

  6. "I couldn't help myself!" by grub · · Score: 1


    "Really, sweetie, the beer store smelled like cookies!"

    --
    Trolling is a art,
    1. Re:"I couldn't help myself!" by Lord+Kano · · Score: 1

      And the cookie store smelled like beer.

      Mmmmm, Beer.

      --
      "Hi. This is my friend, Jack Shit, and you don't know him." - Lord Kano
  7. Serotonin by RAMMS+EIN · · Score: 2, Insightful

    Now if they could only come up with a product that resulted in increased serotonin levels, I'd buy it in a heartbeat!

    (Serotonin is involved in depression and anxiety disorders.)

    --
    Please correct me if I got my facts wrong.
    1. Re:Serotonin by danpat · · Score: 1

      It's called "exercise". I believe Chuck Norris has a patent on it.

      http://www.mayoclinic.com/health/exercise/HQ01676 (see point 5)

    2. Re:Serotonin by Anonymous Coward · · Score: 0

      Ummm like ecstacy?

  8. Moo by Chacham · · Score: 1

    Dopamine:

    Caused by information.
    Creates code monkeys that actually work.
    Used as a natural reward.

    IOW, reading Slashdot causes people to work, who can then be rewarded with reading more Slashdot. Or, Slashdot is the Pravda of the Digital Proletarian. Hmm, the slash is the action of the sickle, the dot looks like a star, if we could just hammer away at the idea of changing the green to read, and removing all the non-Socialist comments here.

    Unfortuantely, this latest find is probably ther work of evil capitalist swine (detectable by his silly use of the awkward word "experiencer", when "subject" is more apropriate). And we should not tolerate this latest insolence.

  9. Be aware of subversive marketing by Rosco+P.+Coltrane · · Score: 2, Interesting

    and you won't ever be a victim of impulse buying. For example, whenever I go to a mall and I smell freshly baked bread, I always remind myself that it's a synthesized flavor in a can that one of the employee periodically sprays around the entrance (go to a bread or cookie shop in a mall, I guarantee you there's no equipment there that can produce real freshly baked bread smells). Same for car dealership: it's very well known that they spray "new car scents" inside the car, even in second hand cars.

    Same for things for sale that look too clean or too well kept: I always try to picture the thing with normal everyday-use dirt on it before buying. Cars come to mind, they're never dirty when the salesman shows them to you.

    So my rule of thumbs is: if it suddenly smells good in odd places where those smells shouldn't be, or if I see things that look too good, I automatically go into "beware of impulse buying mode".

    --
    "A door is what a dog is perpetually on the wrong side of" - Ogden Nash
    1. Re:Be aware of subversive marketing by Anonymous Coward · · Score: 1, Funny

      So my rule of thumbs is: if it suddenly smells good in odd places where those smells shouldn't be, or if I see things that look too good, I automatically go into "beware of impulse buying mode".

      I'll try to remember that next time I'm at the strip club!

    2. Re:Be aware of subversive marketing by ScottSpeaks! · · Score: 1

      The church I went to as a kid was near a bakery, resulting in the wondrous smell of fresh bread on Sunday mornings. I certainly "bought" a lot of things there that I regretted later.

    3. Re:Be aware of subversive marketing by Anonymous Coward · · Score: 0

      Someone should let car dealers know that "new car smell" is terrible and that it makes me nauseous. That doesn't make me want to buy a car nearly as much as they think it does. Might I suggest that they start spraying "freshly-baked bread smell" in its place. That won't make me want to buy the car, but hopefully it's less likely to make me feel like spewing chunks in their automobile.

      Oh, and I had a friend that worked in a mall making baked goods when we were youngsters and I don't see why you think that's from a can. What mall have you been to that doesn't have ovens and doesn't have baked goods prepared on-site? About the only thing that would make me want to buy is baked goods, anyway. Other than a dremel I don't think I've ever bought anything from a mall besides food. Malls are more appealing to females for shopping, unless you like wearing stuff from the GAP or something.

    4. Re:Be aware of subversive marketing by no_pets · · Score: 1

      Perhaps you are hyper-sensitive to smells such as I am. To me most purfume smells like bug spray and I would notice a freshly baked bread smell. But usually when I point out smells (such as bug spray perfume that sends me into an asthmatic fit) to people in my vicinity they most always say that they did not even notice.

      Sure, this is anecdotal evidence, but I do know that some people only subconsiously notice these smells. I wonder if these people buy after smelling freshly baked cookies.

      --
      "A government is a body of people, usually notably ungoverned." - Shepard Book Quoting Malcolm Reynolds
    5. Re:Be aware of subversive marketing by tuffy · · Score: 2, Informative
      Someone should let car dealers know that "new car smell" is terrible and that it makes me nauseous.

      The "new car smell" is simply a side effect of all the plastics involved in its construction airing out. It doesn't really come in a can.

      --

      Ita erat quando hic adveni.

    6. Re:Be aware of subversive marketing by quag7 · · Score: 5, Insightful

      This is actually key - and not just subversive marketing but marketing in general. My own mental habit when watching television - and this is automatic; I couldn't *stop* thinking this way - is to sort of "remote view" the conversations in the advertising agency, and then reduce the commercial down to its essential elements:

      "Lifestyle. If I don't own this, I'm not cool."

      "Buy this and it will get me laid." (I salute the various body spray ads using this technique so nakedly, it was probably considered risky when first proposed - it's one thing to subtly add sexual imagery to commercials - it's another to just make a naked claim that a product will get you laid. And it's worked. Which says very little for the modern 18-24 year old male, frankly.)

      Then I picture the imagery the agency decides on, the song choice, and how it was conceived, laboratory style, to try to manipulate me.

      I apply the same mental circuits to religion, ideology, and so on.

      When this mental process becomes automatic, the desire to consume drops significantly because it generally makes me feel somewhat insulted - the usually cheap, manipulative nature of advertising and so on. Even great advertising is pretty bad if you break it down to its calculated, constituent parts.

      As Rosco P. Coltrane (how's Flash doing btw?) mentions, it's increasingly necessary to be aware of these things whenever you expose yourself to any kind of retail environment, for the reasons he lists.

      Lastly, avoid retail environments altogether unless you specifically want to buy a certain product.

      It's hard for me to get wound up about consumer culture because it really requires only a few easily-learned habits to innoculate yourself against it. Like anyone else, I buy products, but I research, especially higher-end items, to the point of analysis paralysis, before putting my money down. I take a shopping list with me to the supermarket.

      Sheriff Little of Chickasaw county agrees, btw.

      The smell of bread or cookies or whatever, will probably initially cause this thought: "mmmm cookies."

      The immediate second thought should be, "How cheap and insulting."

    7. Re:Be aware of subversive marketing by Anonymous Coward · · Score: 0

      Most strong odors make me nauseated and give me headaches. Perfumes, cleaners, hair sprays, bug sprays, and basically anything else that comes in a can or spray bottle and a few of the perfumes present in soaps. It's not all strong odors, since things like gasoline don't bother me at all, but mostly the scents added to act as "perfumes." I don't have asthma or any allergies, but I definitely notice these odors wherever they're present, since they encourage me to leave. This has given me a real aversion to heavily chemically-treated women as well. I bet telling them "You make me want to throw up" would be pretty insensitive, but it would be rather accurate.

    8. Re:Be aware of subversive marketing by Reziac · · Score: 1

      In a similar vein, I'm sure the effect in discussion is exactly why there are so many irrelevant pictures of Happy Sexy People on sites that sell stuff.

      But when I see a useless picture of Happy Sexy People on a website, I'm instantly turned off. I'm not there to be happified or masturbated, I'm there to do some task, and the Happy Sexy People cue tells me that the site wants to Sell Me Something I Don't Want.

      And yes, I have very high marketing resistance :)

      --
      ~REZ~ #43301. Who'd fake being me anyway?
    9. Re:Be aware of subversive marketing by bcmm · · Score: 1

      I'm sure it's occurs by accident in new cars. However, it is so strongly linked to buying a nice car by some people that it wouldn't surprise me if they try to fake it in old vehicles.

      --
      # cat /dev/mem | strings | grep -i llama
      Damn, my RAM is full of llamas.
    10. Re:Be aware of subversive marketing by eln · · Score: 1

      There do exist "new car smell" air fresheners you can put in your old jalopy to make it smell "new." They usually aren't a perfect analog to the real (probably toxic) crap that produces the real new car smell, but they are at least sort of close. I don't know if any car dealers use it, but it wouldn't surprise me if they did. Personally, the couple of times I've bought a car old enough for the new car smell to have totally faded, it definitely did not smell like new car. It smelled like old car. So, at least at the dealerships I've bought old cars from, they don't spray anything in them.

    11. Re:Be aware of subversive marketing by eln · · Score: 1

      I agree with just about everything you said. In my case, though, if the smell of bread or cookies immediately makes me want to buy bread and cookies, it usually means I was hungry before I got there. If I'm already full, those smells don't have nearly the same effect on me. So, if I get a powerful urge to buy something after smelling it at the grocery store, that's usually my cue that I need to leave the store and eat something before I do my shopping. I am much more likely to buy food I don't really need, and therefore overspend, on a grocery trip if I go there hungry. I generally try to grocery shop shortly after a meal.

    12. Re:Be aware of subversive marketing by bcmm · · Score: 1

      I do wonder exactly who is affected by TV advertising. Is everyone aware that advertising is trying to trick them into thinking in a certain way, but are subconsciously effected by it anyway (and if so am I affected by it even though I hate seeing adverts)? Or are there people who just feel that adverts are literally intended to "advertise", i.e. helpfully inform us that a useful product is available?

      I wonder why there are absolutely no adverts which are intended to give you a good idea of why you should get they thing they want you to get. If I saw an advert which briefly listed the specs of a new device without eulogising it, I might be more likely to buy it, but as it is almost all adverts advertise things I've already heard of and formed opinions about.

      I've not consciously trained myself, but I too almost always notice the intended message of adverts. "It'll make you a better parent" is one of the most common on UK terrestrial TV - pictures of happy families and kids.

      --
      # cat /dev/mem | strings | grep -i llama
      Damn, my RAM is full of llamas.
    13. Re:Be aware of subversive marketing by Zinho · · Score: 1
      The "new car smell" is simply a side effect of all the plastics involved in its construction airing out. It doesn't really come in a can.

      I beg to differ.

      While you are right that new cars have a distinctive smell when they come from the factory, time in the sun at the dealership should destroy the chemicals that cause it over a relatively short period. And it's certainly out of place in a used car. The products exist, and evidence suggests they are in common use in the auto sales industry.
      --
      "Space Exploration is not endless circles in low earth orbit." -Buzz Aldrin
    14. Re:Be aware of subversive marketing by AcidLacedPenguiN · · Score: 1

      You're damn right you should regret buying drugs from the two stoners hanging around the front of the bakery! For Shame!

      --
      disclaimer: I've been known to store numbers in my ass for which to dig out when quantities are required.
    15. Re:Be aware of subversive marketing by Al+Dimond · · Score: 1

      Best example of Happy Sexy People ads I've seen... when I was on a bus in Champaign, IL I saw an advertisement for a church that said, "[insert church name]: Church is not a spectator sport!" and then had three pictures of HSP faces... if there was anything else on the ad it was either too small to read or not very memorable. One of the pictures was a slightly overexposed shot of an semi-airhead-looking blonde chick that looked like her mind was totally blown by God, or by an acoustic-geetar sing-a-long about God, or something like that.

      A few months later I was driving south on the Stevenson through the southwest 'burbs (near Downers Grove or Lemont) and saw a billboard for a new housing development. Three HSP pictures. One of them was the exact same picture that the church ad used. That girl's mind was totally blown by a spacious backyard, french doors and prices from the low $200s. And by an acoustic-geetar sing-a-long about God, of course.

    16. Re:Be aware of subversive marketing by Reziac · · Score: 1

      Oh, that's a good one... the message I get is that you're supposed to buy a house for god. Or maybe that your god is supposed to buy you a house. :D

      The HSP images that bug me the most are on Godaddy and Edison's sites. Total waste of bandwidth, plus I've seen 'em in print ads and they were a waste of ink then, now a waste of some 200k of my very limited dialup straw PER PAGE. Yet the sites don't work with images turned off, so... suffer!

      --
      ~REZ~ #43301. Who'd fake being me anyway?
    17. Re:Be aware of subversive marketing by Anonymous Coward · · Score: 0
      "Lifestyle. If I don't own this, I'm not cool."

      Here, dude, put on these sunglasses and you'll see things more clearly.

    18. Re:Be aware of subversive marketing by Anonymous Coward · · Score: 0

      It is actually quite a common problem. I find the cheaper perfumes like Avon will give me a huge migraine very quickly. My partner is also highly sensative to perfumes. Toilet paper, perfume, after shave, hair conditioner, underarm deoderant are all triggers to quite a violent illness. The unfortunate thing is that most people just look at you like you are imagining things or entirely making it up when you tell them.

  10. DAMN! by gEvil+(beta) · · Score: 1

    Damn! I was really hoping that slashdot was going to give me a link where I could impulse-buy vast quantities of dopamine...

    --
    This guy's the limit!
  11. buzzkill by 10100111001 · · Score: 1

    FTA- "...they applied tetrodotoxin (TTX), a neurotoxin that blocks the active release of dopamine, to the nucleus accumbens and prefrontal cortex. TTX caused dopamine levels to drop..."

    Lab Rat- "you're totally bumming me out with that neurotoxin, dude."

  12. I'm imune! by crunch_ca · · Score: 1

    My browser automatically deletes fresh cookies.

  13. I don't do impulse shopping by Anonymous Coward · · Score: 0

    Buying new things usually entails a lot of planning and researching before making a decision, and old products I am familiar with like groceries and such I buy as needed.

    So what's wrong with me? Well, other than going over purchase decisions in my head for ten minutes when deciding what books to buy. Should I start snorting chocolate, so I can know the joy of impulse shopping?

    1. Re:I don't do impulse shopping by AcidLacedPenguiN · · Score: 1

      you obviously missed out on freebasing cookies. http://science.slashdot.org/comments.pl?sid=200959 &cid=16453683

      --
      disclaimer: I've been known to store numbers in my ass for which to dig out when quantities are required.
  14. Ummmm you have lots of choices by BitterAndDrunk · · Score: 2, Insightful
    That's the whole point of Paxil, Prozac, and Wellbutrin I believe.

    IANAD but they're all called "seratonin uptake inhibitors" and the gist is they stop your brain from reabsorbing seratonin and therefore increasing the constant level found in your brain.

    If you want to get really wacky, you can take MDMA (ecstasy) and have ALL of your seratonin flood into the brain at once, getting tracers, a "bulletproof" feeling, and (to quote Ali G) the desire to dance like a prick.

    Finally, a more reliable way to increase your seratonin levels is through eating right and daily exercise. I'd lean much more heavily on this method rather than any sort of drug for this, as messing with the brain directly is a bit. . . ponderous. Lots of side effects from Paxil/Prozac/et al and they're ALL addictive. Even when they say they're not. Paxil claimed to be non-addictive for a while, and it was on the market for over 2 years before the drugco went "oops, looks like it is addictive! Our bad! But look at its profitability!"

    Legalized drug dealers, indeed.

    --
    You better watch out, there may be dogs about . . .
    1. Re:Ummmm you have lots of choices by RAMMS+EIN · · Score: 2, Insightful

      ``That's the whole point of Paxil, Prozac, and Wellbutrin I believe. ...

      Finally, a more reliable way to increase your seratonin levels is through eating right and daily exercise.''

      Yes, and sunlight, certain foods (nuts, live vegetables, and sweet things, I believe), therapy, and, most importantly, talking to people!

      The problem with all these things besides the drugs is that, when you're depressed, it can be hard to do anything at all, including the things that improve your situation.

      --
      Please correct me if I got my facts wrong.
    2. Re:Ummmm you have lots of choices by antifoidulus · · Score: 1

      Obligatory Simpsons: Marge and Homer are talking with 2 doctors who want to give Bart "focusin" pills to treat his ADD:

      Pharm. 2: Yes, but it's not about slavery, it's about helping kids
      concentrate. This pill reduces class clownism 44%.
      Pharm. 1: With 60% less sass-mouth.
      Pharm. 2: The only thing more effective is regular exercise.
      [Homer shudders]

    3. Re:Ummmm you have lots of choices by treeves · · Score: 1

      I figured he was joking and should have been modded Funny, not Insightful. Oh well.
      BTW Wellbutrin (bupropion) is not a SSRI, it affects, wait for it. . . dopamine.

      --
      ...the future crusty old bastards are already drinking the Kool-Aid.
    4. Re:Ummmm you have lots of choices by treeves · · Score: 1

      Ha. That was my 2^8th comment.

      --
      ...the future crusty old bastards are already drinking the Kool-Aid.
    5. Re:Ummmm you have lots of choices by plcurechax · · Score: 1

      Wellbutrin (bupropion) is not a SSRI, it affects, wait for it. . . dopamine.

      It is a reuptake inhibitor for both dopamine and norepinephrine. I don't remember if it is doage specific (some dual action reuptake inhibitors act differently with different dosage amounts).

    6. Re:Ummmm you have lots of choices by plcurechax · · Score: 2, Informative

      Finally, a more reliable way to increase your seratonin levels is through eating right and daily exercise.''

      In healthy, unstressed people.

      Be careful how this statement is read, there is no evidence that depression is brought on by a poor diet or lack of exercise, and I don't know if an occurance of depression is considered less likely through diet and exercise (it is not 100% preventable by diet and exercise alone).

    7. Re:Ummmm you have lots of choices by curunir · · Score: 2, Insightful

      Paxil and Prozac are SSRIs, Wellbutrin is not. Wellbutrin targets norepinephrine which is why it can, in a slightly different formulation, treat smoking addiction (that formulation is sold under the name Zyban). And, just to be pedantic, it's "Selective Seratonin Reupdake Inhibitors"...

      However none of these drugs, MDMA/MDA included, result in more seratonin, they only change the way your brain deals with the seratonin you have. If you want to have more seratonin, the dietary suppliment 5-HTP is your best shot. However, this will only work for people who's bodies aren't producing enough seratonin to begin with.

      As to their addictiveness, yes, they have withdrawl symptoms, but those can be mitigated by titrating off the drug slowly. However, in the vast majority of the cases, they do not have any of the other properties of addiction that make it hard for the patient to stop using them. I'm not sure why so many people insist on demonizing the pharmaceutical companies that make anti-depressants. Are they perfect? Not even close. But have they helped people overall? I've met too many people who've basically reclaimed their lives because of these drugs. There's a lot that needs fixing in this country when it comes to both prescription and illgal drugs. But a one-sided view on either is just plain wrong. Both types of drugs, if used correctly can have very positive outcomes. And if the government would pull its head out of its ass for long enough to allow scientists to study the effect of MDMA on the human brain (and I mean real studies, not the Recaurte crap they currently fund), we might learn something about how our brain really uses all these neurotransmitters we have. For example, wouldn't it make sense to commission studies on why MDMA has the effect it does on Parkinsons' patients? (in case you don't want to look it up...the symptoms basically go away for the duration of the high).

      We're at a critical juncture when it comes to learning about how the brain works. What we need now is a lot of unbiased research into how the brain works and reacts to these substances that we've come up with (and will come up with). Unfortunately, uninformed opinions (like the one espoused by the post I'm replying to), politics and huge pharmaceutical profits are and will continue to get in the way of this.

      --
      "Don't blame me, I voted for Kodos!"
    8. Re:Ummmm you have lots of choices by plcurechax · · Score: 1

      Lots of side effects from Paxil/Prozac/et al and they're ALL addictive. Even when they say they're not.

      I'd love to see your evident to back that claim. I don't know of any psychological addictions to any anti-depressant. Anti-anxiety drugs are a different matter (e.g. tranquilizers). Any claim to physical addiction is easily "defeated" through a simple straight forward "weaning" process.

    9. Re:Ummmm you have lots of choices by Miniluv · · Score: 1

      It is indeed dosage specific. Which is why at one dosage it's Welbutrin and is used to treat depression but at another it's Zyban and used to quit smoking. I'm on the latter at the moment, and will probably be on the former once my cravings disappear.

    10. Re:Ummmm you have lots of choices by mrogers · · Score: 1
      (it is not 100% preventable by diet and exercise alone)
      But you'll be too tired and hungry to notice.
    11. Re:Ummmm you have lots of choices by duguk · · Score: 1

      > simple straight forward "weaning" process.

      Then it is still addiction, I should know - I take SSRI's myself.

      There is a difference between physical dependence (characterized by symptoms of withdrawal) and psychological dependence (or simply addiction).

      SSRI's are physically dependant, they do cause withdrawal symptons. Naturally, they would though - they affect brain patterns very deeply. Though that is not to say that they are particually difficult to wean yourself off them.

      This seems an interesting study though. I would be interested in comparsions to Dopamine and SSRI's and will be looking around for them.

      Dug

    12. Re:Ummmm you have lots of choices by plcurechax · · Score: 1

      I would be interested in comparsions to Dopamine and SSRI's and will be looking around for them.

      Most GP / family doctors are still using SSRI as a first line of choice for prescribing, psychatrists are most often prescribing SNRI, and atypical anti-depressants depending on the patient.

      Wellbutrun, Effexor (sorry, US brand names) are the biggest two (market share) non-SSRI with others available as well (~8-10 in total I think).

      Don't expect dopamine pills, these are still re-uptake inhibitors that appear to work on a different neuro-transmitter chemical.

    13. Re:Ummmm you have lots of choices by maxume · · Score: 1

      SSRI -- Selective serotonin reuptake inhibitor. Wikipedia appears to be reasonable:

      http://en.wikipedia.org/wiki/Selective_serotonin_r euptake_inhibitor

      They don't change the level in your brain, but they cause what is there to have a greater effect.

      --
      Nerd rage is the funniest rage.
  15. Don't tell Tesco by Bob+Gelumph · · Score: 1

    They'll be blasting people with the stuff on entry to their stores.
    I wonder if it also stops people paying attention as much so they don't notice the blatant mistakes all over their dockets.

    --
    I'm gonna need a spec.
  16. Free cookies? by SeanTobin · · Score: 1

    Does this mean that Amazon will send me free cookies with a card reminding me to check out my gold box?

    If so, I'm all for it!

    --
    Karma: SELECT `karma` FROM `users` WHERE `userid`=138474;
  17. Great... by plate_o_shrimp · · Score: 2, Insightful

    After hammering me with loud TV and radio ads, assaulting my eyeballs with garish print and web ads, flooding my inbox with email ads, and littering the landscape with signs and billboards, the marketers have come up with another to try to make me buy crap I don't want. I'm pretty good at resisting, but damn I get tired of this crap in my face all day long. Just go away, dammit! :-)

    --
    This sig has exceed its monthly bandwidth allotment.
    1. Re:Great... by RAMMS+EIN · · Score: 1

      Speaking of 'crap', there's an excellent idea to complement the encouragement that dopamine offers...

      --
      Please correct me if I got my facts wrong.
  18. browser cookies? by swatthatfly · · Score: 1

    I will think twice now before clearing my cookies.

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    keyboard not found! press any key to continue...
  19. There's a simple solution to this... by horati0 · · Score: 1

    ...just get yourself addicted to coke. A few lines here and a half a gram there, and you'll find yourself on eBay selling shit so you can score more blow.

    --
    The neutrality of this sig is disputed.
  20. yep by iluvovaltine · · Score: 1
    Forbes had an article recently about how a company is making a killing selling smells to other companies. You walk by a store and that fresh-baked cookie smell hits you and there you go, a sale is chemically forming.
    Novelty releases dopamine. I think this is why apple is the way it is. They have products that look and feel so differently.

    Info like this is really good to know so that you can analyze your own brain in various contexts in which someone is trying to manipulate you. It happens, and it is only bad when you don't know and don't care when it happens. And then it is only bad for the individual, it is good for the manipulator and the economy.

    --
    Die when you die -GG Allin
  21. Snack bar up front by psydeshow · · Score: 1

    ... and suddenly it becomes obvious why the snack bar at Walmart is right there when you walk in the door, bathing your unsuspecting synapses in popcorn, hotdog, and cotton candy smells.

    Mmmm, dopamine. And look, a plastic lawn chair at just $18.95!

  22. Go ahead by surfcow · · Score: 3, Insightful

    Go ahead. Click that moderate button. You know you want to.

  23. HEY! by BitterAndDrunk · · Score: 1
    I'm allowed to be uninformed, that's what the IANAD tag gets me!

    Additionally, I don't set policy or have any influence on either policy-making/research so. . . here's to ignorance! *quaffs Serotonin Uptake Inhibitor Potion +3*

    (thanks for the clarifications on my post - I'm not a doctor nor do I pretend to have more than a passing knowledge of pharmaceuticals. I do agree 100% with your post that we need to do more research on MDMA and remove the bias presented towards some drugs (i.e. untaxed drugs) particularly when it comes to the brain.)

    I still think anti-deps are over-prescribed.

    --
    You better watch out, there may be dogs about . . .
  24. re: Paxil by BitterAndDrunk · · Score: 1
    A link

    A cursory google search turned up a class action suit against Glaxo and a whole slew of links associated with it and Paxil. Mostly lawyers attempting to cash in, but the link above was one that wasn't lawsuit-oriented. I think. TBH I didn't read any of it but the headline.

    Stating that all of them are addictive was hyperbole, spurred by cynicism towards our drug-makers.

    --
    You better watch out, there may be dogs about . . .
  25. Re: Paxil by plcurechax · · Score: 1

    A cursory google search turned up a class action suit against Glaxo and a whole slew of links associated with it and Paxil. Mostly lawyers attempting to cash in, but the link above was one that wasn't lawsuit-oriented. I think. TBH I didn't read any of it but the headline.

    So plenty of claims, many involving money, but no evidence.

    With a google search I think you can also find class actions suits against Santa Claus or the Easter Bunny.

  26. Yeah, it's called hunger... by mattwarden · · Score: 1

    Certain stimuli in the brain, such as the smell of freshly based cookies, lead to higher levels of dopamine that remain after the stimulus is removed

    Um, yes. It's called hunger. Hunger is a feeling brought on by external stimuli (smell, sight, etc.) or internal stimuli (the thought of food, etc.). This does not necessarily generalize into whether or not someone will buy the newest Barbie upon sight.

  27. LEATHER CLEANER == NEW CAR SMELL by Anonymous Coward · · Score: 0

    Really. I just bought some Mothers Leather Cleaner goo and used it. Now my car smells brand new. If you don't have leather try rubbing it into your hair.

  28. Shopping malls have known this for long by bigmouth_strikes · · Score: 1

    This phenomenon has been used in stores and most notably shopping malls for a long time. Specific music and specific scents increase the amount of sales significally.

    Article about study: http://ur.rutgers.edu/medrel/viewArticle.html?Arti cleID=4506

    --
    Oh, I can't help quoting you because everything that you said rings true
  29. Smell of Fresh Dope does *What*? by Anonymous Coward · · Score: 0
    Ah, the smell of freshly-picked dope, hand-rubbed, vaporized.... What were we talking about again? Oh, hey, there's this plate of cookies here, I should have another, encourage that positive feedback loop...


    Actually, dope does work on the endo-cannabinoid receptors, and there's been some recent work about manipulating them (I forget if it was blocking them, or blocking reuptake, or quite what) to reduce feelings of hunger for weight-loss purposes, basically the opposite of getting the munchies.