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Scientists Image an HIV Particle Being Born
FiReaNGeL alerts us to a huge development in virology and microscopy: by using a specialized microscope that only illuminates a cell's surface, scientists at Rockefeller University have watched, in real time, hundreds of thousands of molecules coming together in a living cell to form a single particle of HIV-1. A video is available on Rockefeller's front page. "By zeroing in at the cell's surface, the team became the first to document the time it takes for each HIV particle, or virion, to assemble: five to six minutes. 'At first, we had no idea whether it would take milliseconds or hours,' says Jouvenet. 'We just didn't know.' 'This is the first time anyone has seen a virus particle being born,' says Bieniasz, who is an associate professor and head of the Laboratory of Retrovirology at Rockefeller and a scientist at the Aaron Diamond AIDS Research Center. 'Not just HIV,' he clarifies, 'any virus.'"
A viral video that benefits science?
This video was made by the US military 20 years ago when they were developing HIV.
When they used to say that the time it took a Windows computer to go from the first boot time to an infected state was about five minutes.
Coincidence?
The dangers of knowledge trigger emotional distress in human beings.
Not to be premature, but if they are able to cure viruses, there is going to be a second sexual revolution. No condoms, ever again? HOORAY! Everyone throw your HATS IN THE AIR! (Jim-hats, that is). Then all we need is a safe version of the male 'pill', and everything is set, set, set!
Push, Honey! PUSH!
I get the home page OK. On there is a link to where the video is: http://newswire.rockefeller.edu/?page=engine&id=763 That page loads too, with the following text where I assume the video would be: "Error! Unable to locate the News Relase you specified."
Nobody understands it because it doesn't make sense.
The pharmaceutical companies (or any companies at that) don't care about the good of the industry in general, they only care about the maximization of their own profits. If one company discovers the HIV cure before the others, it is going to make sh&tloads of money, giving it a huge step ahead of the competition and allowing it to tap exclusively into a marketshare that it has up till now only shared.
While I applaud the work, I am not entirely convinced that this article is "Nature" worthy. True enough, it shows something that has not been directly observed before, but does it describe a phenomenon that is entirely novel? This data merely confirms what has been known about HIV assembly, while enabling to observe kinetics.
Maybe, I am wrong, but I would like to see a bit more data in this article. I suspect this might be one of these cases of "publish this before anyone else does" and then follow with many derivative articles.
Look honey...it looks just like you!
no comment
I saw God's finger poke into the mix at 0:34.74sec of the video. I told you! ... hmmm, or maybe it was a noodly appendage.
Table-ized A.I.
But nonetheless custom dictates that we ought to all stand around and politely congratulate the parents.
Do it yourself, because no one else will do it yourself. [beta blockade 10-17 Feb]
Intriguing that we can view so small a thing yet not have much in the way of controlling or manipulating it the way we would like to. Also, pretty fascinating for something that is not alive.
That's pretty amazing, especially considering the video is less than 15 seconds long.
Better known as 318230.
So could someone explain how this effects us? How is this a major leap as the article says? Watching it be born seems cool and all but how does that help us kill it?
You may have fooled me once but I won't be rickrolled again!
Well, they do spend more on marketing than they do actual research...
Forget thrust, drag, lift and weight. Airplanes fly because of money.
Dude, let's put it like this:
Any company which discovers a cure gets a monopoly (patent) on it for 20 years. Which is a lot.
Now picture having this choice:
A. You get the existing anti-virals which tend to do a lot of damage. (There's a reason you don't get them for a cold or even a flu: they do more damage than the flu.) And they might or might not work. In fact, you'll probably just buy you some time. And everyone makes them, so while there's some money milking potential in the "but mine work better" factor, you're still just getting a slice of the pie.
B. You get the miracle cure from Company X, which actually works and presumably with a lot less side effects.
Choice B is a no-brainer. The company which would get a 20 year monopoly on B, is going to sit on a freaking huge fortune at the end of those 20 years. Not only they'd get the lion's share of the existing pie, they'd get a whole merry bunch of retards who'd rather buy the cure later than use a condom. Again.
So basically, you're telling me that a whole lot of CEOs, doctors, their investors, etc:
1. Would rather work for the general benefit of their competitors in preserving a status quo, instead of making a metric buttload of money for themselves.
2. A lot of rich and powerful people, and some of those same CEOs, doctors, etc, would rather die themselves or watch friends and family die a slow death, than just use that supposed miracle cure.
3. Thousands to millions of underlings, who otherwise can't seem to keep much else secret, just toe the line on this one. And again, would rather be loyal to some cartel than save themselves or their friends and family in some cases. And all the retards who lose laptops, or get internal corporate networks virused, etc, lose everything _except_ this apparently. They lose customer files, they leak that their network has blank admin passwords, etc, but somehow they never manage to leak _that_.
4. Somehow the Chinese, Russians, and a fucking buttload of other governments just itching for a pretext to one-up the West, and thumb their nose at the West, also toe that line peacefully. And, you know, all the retards like those in South Africa and various other countries, peddling sweet potato juice and other local snake oil as cures for HIV and as a substitute for paying to the big pharma for a cure, don't just go ahead and and make that miracle cure.
Remember: if it's secret, then it's also not patented. Patents tell everyone that it exists, so they don't work well for a conspiracy.
Etc, etc, etc.
And the same goes for diabetes, cancer, and all the other poster cases used by such conspiracy theories. In fact, for a lot of them half the points above go double. (E.g., insulin is out of patent, and it's a commodity produced by everyone, so profit margins are tiny. Plus you have local factories which don't pay big pharma a cent. So patenting a cure would make a lot of people very very rich. E.g., cancer doesn't really have as easy a defense as using a condom, and as other diseases go down and life expectancy rises, so does the chance that you'll live enough to get a cancer. So that one requires literally believing that the millions of doctors, researchers, pharma bigwigs, etc, would rather die of it and do something as brutal as radiotherapy or chemotherapy, instead of using the miracle cure. Etc.)
So here's an idea: noone understands that conspiracy theory, because it's fucking stupid even as conspiracy theories usually go. It doesn't require even just delusions and or building whole rationales on silly suppositions instead of facts. It requires genuine inability to follow even elementary logic.
A polar bear is a cartesian bear after a coordinate transform.
The article and video show individual HIV particles emerging from a cell. There isn't any imaging of "hundreds of thousands of molecules coming together" to form the particles. Or am I missing something?
Perhaps I simply don't see a more elegant solution, but it seems that in order to eliminate the need for marketing in drug development competition would need to be eliminated (perhaps by the creation of some national or international regulatory authority?), but I haven't often heard people suggesting that be done. Thoughts?
Thats why I linked directly to their front page, its weird, they screwed up something
Eureka Science News - automatically updated
I can refute it. Everyone who is working for a profit motive is a selfish evil bastard who wants the gays and the druggies to get what's coming to them. Everyone working for a non-profit is doing it out of a selfless desire to do good and improve the world, even if it means they eliminate the condition for their employment. Duh.
the wolf brings to the table his warrior's instincts, his brains and his training. the sheep remains a sheep no matter how well armed.
Owning sheep, I'd like to clarify...
Sheep will try to defend themselves, but they lack the ability to form an alliance with other sheep or prey animals... Sheep will try to attack once or twice. The only tool they have is ramming. And adult male sheep (Rams) do in fact kill lots of humans every year.
Most canine predators have the ability to form alliances for the common good, and they have really good predator teeth.
Sheep lack teeth for attacking, and they have an attitude of "give-up, roll over & die". You see this when you vaccinate. The vaccinated lambs take a few steps, roll over and wait for death. After about 5 minutes, they realize that death has passed them by, they get up and seek out mom for a drink. I can't see the evolutionary advantage in this strategy, we might have bred it into them.
- High Tech workers, please say NO to Union Carpenters, their Union sees fit to control our compensation.
NewswiseScience News.
(The link from the Rockefeller University main page is currently broken).
"How to Do Nothing," kids activities, back in print!
I thought particles are for the most part pieces of matter, regardable as uniform in structure. I do not work with viruses--are individual viruses referred to as particles?
There is something about the theory of fractal similarity at different scales--HIV gathering on a cell resembles flies assembling on dead meat.
The video caption is "individual HIV particles (white spots) assembling on the surface of an infected cell" but the article is titled "single HIV particle". That's fishy.
Know your pads. One time pad: good for cryptography. Two timing pad: where to take your mistress.
Are you SURE that's the reason you pick a female doctor?
I may agree with what you say, but I will defend to the death your right to face the consequences of saying it.
That is interesting. What a scary form of birth...
When you refer to drug companies, what aspect of them do you think of that you can personnify with the characteristic of "liking things?" The people I know in pharmaceutical research (me included) are a cynical bunch who dearly hope to invest their lives in helping other people live happier lives.
Enable javascript.
Yep. Me, too. Mirror anyone?
The evolutionary advantage of a herd animal, being common prey, to roll over & die is in protecting the rest of the herd. They bred it into themselves, not us, ie. evolution. You see this in the elderly herd too, they will wander away, or on the outside of the pack in a way to allow themselves as the sacrifice so the predator gang will take them and leave the strong, the females, and the young
Computers allow humans to make mistakes at the fastest speeds known, with the possible exception of tequila and handguns
So you're telling me that none of that would fund someone with a patent that gives them near-monopoly on treating AIDS, for _20_ years?
I see you've supplied your own proof against the conspiracy theory. Cures _are_ being researched, and there _is_ a recurring revenue in those.
The recurring revenue aspect, which you mention is this: that people keep getting the disease again, or new people get it. It's not like there's a shortage of new people getting STDs, or cancer, or whatever.
It's also missing the aspect of how big that revenue is. Selling a patented cure is where the big money is. If you milked everyone with diabetes of, say, 1000$ profit for a patented cure, it beats treating a little slice of that market with insulin (because everyone produces it, not only you) at cents profit per shot (because the free market did drive the prices down, as it's supposed to.)
So, anyway, I guess I'm somehow supposed to believe that what applies to anti-biotics (kills bacteria) and anti-fungals (kills fungi), somehow doesn't apply to anti-virals (you guessed what it kills.) That there's a perfectly good financial incentive to fund finding a cure for some bacterial infection that would likely (though not always) go away on its own, but somehow not in curing a viral infection that kills. Something doesn't add up in that conspiracy.
A polar bear is a cartesian bear after a coordinate transform.
Middle. He was flipping off all the scientists.
What if Tetris was invented by Nazis?
You mean fainting goats. Fainting goats freeze for about 5-10 seconds when you scare them. Since goats were cheaper than sheep, people who had many sheep would get a few fainting goats. Then, when the herd was attacked by predators, the sheep would easily get away faster than the goats (which would simply fall down, remember, I dont't need to outrun the lion, I just need to outrun _you_), so the predators would eat the goat and leave the sheep.
:)
Is there any chance you've seen this on QI, the source of all useless knowledge?
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100% Troll
You TrollMods are colossal idiots.
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