Slashdot Mirror


The Average Human Has 60 New Genetic Mutations

mcgrew pointed out a story about a new study that found the average person is born with 60 genetic mutations, very few of which involve weather manipulation or an amazing healing factor. This number was less than expected, leading the researchers to believe human evolution happens more slowly than previously thought. From the article: "Sixty mutations may sound like a lot, but according to the international team of geneticists behind the new research, it is actually fewer than expected. 'We had previously estimated that parents would contribute an average of 100 to 200 mistakes to their child,' Philip Awadalla, a geneticist at the University of Montreal who co-led the project, said in a press release. 'Our genetic study, the first of its kind, shows that actually much fewer mistakes, or mutations, are made.'

173 of 246 comments (clear)

  1. We should regulate mutations... by MobileTatsu-NJG · · Score: 4, Funny

    ...before a little girl passes through a wall at the federal reserve!

    --

    "I like to lick butts!" by MobileTatsu-NJG (#32700246) (Score:5, Informative)

    1. Re:We should regulate mutations... by Space+cowboy · · Score: 1

      You laugh,

      Yes. We laugh at you.

      Simon. (Also a Dr. But I'm a real Dr. People like you give medicine a bad name).

      --
      Physicists get Hadrons!
    2. Re:We should regulate mutations... by redemtionboy · · Score: 1

      They just print paper there. Go to Ft Knox for the gold.

    3. Re:We should regulate mutations... by SETIGuy · · Score: 4, Insightful

      Alternative medicine is just medicine that doesn't work, or hasn't been shown to work. If an alternative medicine is shown to work, they call it medicine.

    4. Re:We should regulate mutations... by MobileTatsu-NJG · · Score: 1

      We don't pay for things with gold.

      --

      "I like to lick butts!" by MobileTatsu-NJG (#32700246) (Score:5, Informative)

    5. Re:We should regulate mutations... by redemtionboy · · Score: 2

      No, but the bricks stack better to make a pimp ass fort.

    6. Re:We should regulate mutations... by crow_t_robot · · Score: 1

      Implement genetic ECC, IMO!

    7. Re:We should regulate mutations... by smooth+wombat · · Score: 1

      .before a little girl passes through a wall at the federal reserve!

      But only if it's Kit from the first X-Men movie. Nothing against Ellen Page, but Sumela Kay is cuter.

      --
      We will bankrupt ourselves in the vain search for absolute security. -- Dwight D. Eisenhower
    8. Re:We should regulate mutations... by mcgrew · · Score: 1

      Not all mutations are harmful. We wouldn't have evolved big brains and intelligence without genetic mutation.

      This is probably bad news for my daughter Patty, who was born with only one kidney, as she found out after a CAT scan. She tells people "I'm a mutant and my dad's a cyborg!" I guess she can still say that, even though everybody's a mutant and most geezers my age have some sort of implanted devices in them these days.

    9. Re:We should regulate mutations... by FredFredrickson · · Score: 2

      Thank you for that. For those of you who want a very entertaining 10 minutes along those lines, check out Tim Minchin's Storm: http://www.youtube.com/watch?v=HhGuXCuDb1U

      --
      Belief? Hope? Preference?The Existential Vortex
    10. Re:We should regulate mutations... by fran6gagne · · Score: 1

      This is stupid. The little girl may pass through the wall, but the gold won't.

    11. Re:We should regulate mutations... by UnknowingFool · · Score: 1

      A mutation is a change. The change can be harmful, beneficial, or neutral. Mutations are expected; it's called evolution. The rate of mutation is actually less than expected. The list of maladies you list are not exclusively dictated by mutations.

      --
      Well, there's spam egg sausage and spam, that's not got much spam in it.
    12. Re:We should regulate mutations... by crypticedge · · Score: 1

      So how would adjusting my spine prevent colon cancer? Last I heard cancer was an uncontrollable growth of cells that the body couldn't kill off, not a misaligned spine.

      I'm not saying getting your spine readjusted doesn't feel good, but don't think your fooling anyone claiming that it will actually fix anything either, because it flat out wont. Basically, a DC is a glorified masseuse, able to make you feel better but not able to actually fix anything and claiming you can is grounds for a huge lawsuit for fraud.

    13. Re:We should regulate mutations... by ChromeAeonium · · Score: 1

      Could I get some thetans to go with my subluxations?

    14. Re:We should regulate mutations... by MBGMorden · · Score: 1

      The joke was likely referring to the comic book character Kitty Pride ("Shadowcat"), who not only can walk through walls, but can make things she's touching/holding phase through them as well. So she could take the gold through too.

      --
      "People who think they know everything are very annoying to those of us who do."-Mark Twain
    15. Re:We should regulate mutations... by MBGMorden · · Score: 1

      Meh - to each his own. There's just something about Ellen Page that I like. I'd rather that version :).

      --
      "People who think they know everything are very annoying to those of us who do."-Mark Twain
    16. Re:We should regulate mutations... by DriedClexler · · Score: 1

      And you know what they call ~50% of medicine that doesn't work? Medicine.

      Not defending alternative medicine, just disputing the characterization of mainstream med as some kind of paragon of rigorous empiricism.

      --
      Information theory is life. The rest is just the KL divergence.
    17. Re:We should regulate mutations... by MobileTatsu-NJG · · Score: 1

      I'm talking about X-Men, not Terminator.

      Geesh, these same convos happen during time travel articles, too!

      --

      "I like to lick butts!" by MobileTatsu-NJG (#32700246) (Score:5, Informative)

    18. Re:We should regulate mutations... by Jason+Levine · · Score: 1

      I've always wondered about "mutations" in the X-Men comic books. There are people whose mutations lead to fantastic powers and there are normal people. I wonder about people in the middle. People who have mutations which lead to mundane powers or even powers which make everyday life difficult. For example, a mutation that makes ones hair grow at 50 times the usual rate. You would need to constantly shave every 6 hours lest you grow a beard not to mention the long tail of hair you would constantly drag behind you. Or perhaps someone would have the absolutely boring ability to change their eye color. Do the X-Men comics ever address people like this or is it just assumed that mutants all have wonderful, fantastic and useful* powers.

      * "Useful" meaning "can be used for the mutant's benefit in some manner" and not "has no downside." Cyclop's eye blasts are useful in a fight even if it means nobody can look him in the eye.

      --
      My sci-fi novel, Ghost Thief, is now available from Amazon.com.
    19. Re:We should regulate mutations... by MobileTatsu-NJG · · Score: 1

      The big speed bump I always run into is "where the heck is the power for these mutations coming from?" It takes energy to lift up metal with a magnetic field and fling it around the room, where's it come from?

      --

      "I like to lick butts!" by MobileTatsu-NJG (#32700246) (Score:5, Informative)

    20. Re:We should regulate mutations... by mcgrew · · Score: 1

      Or perhaps someone would have the absolutely boring ability to change their eye color.

      That mutation has already happened, although I don't know of anyone who can do it at will. My eyes are like that -- My daughter Patty says that when they were kids they could tell what kind of mood I was in by the color of my hazel eyes. Patty inherited that from me, but her mother's brown eyes as well. Patty's is really kind of spooky, her irises turn almost red when she's angry. But it's not voluntary, and I have no idea if it's a benefit or a hindrance, it "just is"

      Patty was also born with only one kidney. That's definitely a bad mutation (1 in 1000 people are born with one kidney). She tells her friends "I'm a mutant and my dad's a cyborg!"; I have a CrystaLens implant in my left eye that gives me a sort of super power -- my eyesight in that eye is better than 20/20 from one foot away to infinity, and I'm 59 years old. Hooray for technology!

    21. Re:We should regulate mutations... by mcgrew · · Score: 1

      Read Asimov's Foundation and Earth. He has people from the planet Solaris with a power like that, and it was explained satisfactorily in the book. That's one thing I always liked about his writing, he always explained away the parts that needed a suspension of disbelief; faster than light travel, for example.

      Another thing I like about his fiction is that he was a real scientist, a PhD in biochemistry who did cancer research while on the faculty of Boston University.

      I like Terry Pratchett because he explains stuff that needs suspension of disbelief in a way that makes the suspension of disbelief unnecessary because the explanation is so ludicrous... and also, he's funny as hell ("He realized that he was not only not the sharpest knife in the drawer, he might even be a spoon).

    22. Re:We should regulate mutations... by mcgrew · · Score: 1

      I'm not saying getting your spine readjusted doesn't feel good, but don't think your fooling anyone claiming that it will actually fix anything either, because it flat out wont.

      I'm not so sure about that. My dad, now retired, got a back injury while working and was off the job for quite a while. His medical doctor told him that surgery was his only recourse, and the surgery was risky and could make it worse but without it he might not be able to work again. Two weeks after seeing a chiropractor he was pain-free and back on the job. AFAIK he never had to go back to the chiropractor.

      I was x-rayed in a hospital after an auto accident, and the radiologist, looking at the pictures, said "you have arthritis". I said "I know, when are you guys going to find a cure?" His reply was "the money's in treatment, there's no money in cures." At least there's naproxin sodium (sigh)

      The "curing cancer with chiropracty" is just plain bullshit, and it's that kind of bullshit that gives chiropracty a bad name. Hmmm, I wonder if I should see a chiropractor about my arthritis? I've never been to a chiropractor.

    23. Re:We should regulate mutations... by toriver · · Score: 1

      Ah, you know of the Fourth Little Pig.

    24. Re:We should regulate mutations... by Sene · · Score: 1

      So the patient would feel good around the back area while dying from cancer? Nice...

    25. Re:We should regulate mutations... by djlowe · · Score: 1

      ...before a little girl passes through a wall at the federal reserve!

      And discovers there's nothing there!

      Sorry, couldn't resist.

      Regards,

      dj

    26. Re:We should regulate mutations... by sfm · · Score: 1

      Kinda like "Bob the Builder"

      A superhero with the ability to do construction !!

    27. Re:We should regulate mutations... by CheerfulMacFanboy · · Score: 1
      Ob X-Men: The school at the X-Mansion is always full with dozens of pupils - I guess those that don't get featured only have minor powers.

      In other media, we have Mystery Men, and in the Disney movie Sky High, the kids with the lesser powers are forced to become sidekicks aka "hero support".

      --
      Fandroids hate facts.
    28. Re:We should regulate mutations... by MBGMorden · · Score: 1

      Or X-Men. Yeah, probably X-Men.

      Erm, Kitty Pride/Shadowcat is part of the X-Men . . .

      --
      "People who think they know everything are very annoying to those of us who do."-Mark Twain
  2. Hogwash! by necro81 · · Score: 2, Funny

    Mutations, smutations! Everyone knows that evolution is bunk and that humans were created in their current, perfect form just 6000 years ago.

    1. Re:Hogwash! by RussellSHarris · · Score: 1

      Who said anything about their current form being perfect? IIRC perfection was lost in the garden of eden.

    2. Re:Hogwash! by RazzleFrog · · Score: 1

      Here you go:

      http://www.amazon.com/Greatest-Show-Earth-Evidence-Evolution/dp/B004AYCWY4/

      And which consensus are referring to exactly?

    3. Re:Hogwash! by bberens · · Score: 1

      By "perfect form" I assume you mean "so evil by design that you deserve to burn in hell for eternity." Well, unless you complete a very specific set of steps to complete the salvation process.

      --
      Check out my lame java blog at www.javachopshop.com
    4. Re:Hogwash! by necro81 · · Score: 1

      IIRC perfection was lost in the garden of eden

      I think most biblical theologians would say that the expulsion from paradise did not corrupt our physical form, just our nature.

    5. Re:Hogwash! by Anonymous Coward · · Score: 1, Informative

      Mutations, smutations! Everyone knows that evolution is bunk and that humans were created in their current, perfect form just 6000 years ago.

      I know many Creationists, and am one myself (thus posting AC), but I've never heard anyone say anything like that. It's really quite shocking how little people understand about Creationists.

      There is a distinct difference between microevolution and macroevolution. If you are unfamiliar with the terms, then look them up. Micro-evolution and natural selection are observed regularly, and are considered fact by Creationists. A great example of observed microevolution is the observation of peppered moths observed near London during the industrial revolution. The genes for both colorations existed in the line for generations, but natural selection greatly changed the ratio of white to peppered over a relatively few number of years. By contrast, macro-evolution has never been observed.

      The theory of abiogenesis (aka primordial soup) assumes that the earth is 4.5 billion years old, and was stable enough for the formation of life after 1 billion years. Even with ~200 mutations per generation, and an age of the earth of 3.5 billion years, even scientists that readily accept macro-evolution are still skeptical that life could have progressed to the state we see today in that amount of time. To deal with the discrepancy, some have resigned that maybe a god of some type was involved, while others look to seeding from extraterrestrial means.

      Generally, Creationists are accused of mixing religion with science, or refusing science because of religion. In general, the feeling is mutual. One's belief of whether or not a God exists should not influence science. Science means "to know", and we should use what we observe as the basis for scientific belief. When someone throws out a theory because of their acceptance or non-acceptance of a God, then this is bad science. Teaching only one theory for the origin of life is clearly bad science.

    6. Re:Hogwash! by FauxPasIII · · Score: 1

      Quick! You're needed two stories up on the climate change topic!

      --
      25% Funny, 25% Insightful, 25% Informative, 25% Troll
    7. Re:Hogwash! by MBGMorden · · Score: 1

      I haven't been to church in quite a few years (but I had to endure service every single Sunday until I left for college), but IIRC prior to leaving Eden Adam and Eve were immortal, and so the whole "whither and die" thing certainly would have been a notch down from the original status.

      --
      "People who think they know everything are very annoying to those of us who do."-Mark Twain
    8. Re:Hogwash! by geekoid · · Score: 1

      Clearly in the bible is says we all look like God..well the men.

      Can creationist often claim our for is perfect...otherwise we couldn't hold a banana!

      --
      The Kruger Dunning explains most post on /. http://en.wikipedia.org/wiki/Dunning%E2%80%93Kruger_effect
    9. Re:Hogwash! by toriver · · Score: 1

      Which is why you would need Eden 1022 for humans from Blond Hair Fair Skin God, Eden 4233 for Red Hair Frecklish Skin God, etc...

      Unless they effing start accepting that mutations are not inherently detrimental to a species.

    10. Re:Hogwash! by mcgrew · · Score: 2

      Only three things are required. Love God, love people, and accept Christ as your savior. Now, there are a lot more steps in some other religions...

  3. Not Mistakes by HisOmniscience · · Score: 1, Interesting

    I would have thought that a geneticist would realize that mutations aren't necessarily mistakes and are key to adaptations and evolution.

    1. Re:Not Mistakes by themightythor · · Score: 2

      But you're assuming that mistakes are detrimental. Mutations are, by definition, a mistake in the genetic copying process.

    2. Re:Not Mistakes by dragon-file · · Score: 1

      Well yea... Just because something is a mistake doesn't mean it isn't necessary.

      --
      Whenever a player quits EVE to go play WoW, the Average IQ of both games increase.
    3. Re:Not Mistakes by SailorSpork · · Score: 1

      Maybe it's that they expected to find 100-200 *variations*, but only 60 of them were significant variations (called "mistakes"), while the rest were variations that ended up being in line with the rest of the gene pool (so not noticed).

    4. Re:Not Mistakes by spauldo · · Score: 1

      Natural selection is just a part of the process of evolution. It's a lot more complicated than that.

      What they're saying here is that since there are fewer mutations in each new human, there are fewer opportunities for new traits to develop, since most mutations don't lead to new traits.

      --
      Those who can't do, teach. Those who can't teach either, do tech support.
    5. Re:Not Mistakes by jd · · Score: 2

      Serendipity is the art of making useful mistakes. Nature is 100% serendipitous.

      --
      It's a small world and it smells funny; I'd buy another if it wasn't for the money; Take back what I paid (SoM)
    6. Re:Not Mistakes by compro01 · · Score: 1

      No, they are mistakes, errors in copying. Just occasionally, they're useful mistakes.

      --
      upon the advice of my lawyer, i have no sig at this time
    7. Re:Not Mistakes by ConceptJunkie · · Score: 3, Funny

      Actually, nature doesn't make mistakes. It just does stuff. Some of the stuff works, some of it doesn't. The stuff that works we consider "evolved." The stuff that doesn't we consider "politicians".

      --
      You are in a maze of twisty little passages, all alike.
    8. Re:Not Mistakes by 0100010001010011 · · Score: 1

      But those mutations and adaptions (unless unseen) will probably not be 'allowed' by doctors. Say 6 fingers is where we're 'supposed' to be headed. Except at birth the extra digits are usually removed, giving a person with that trait no more advantage than anyone else.

      On the other side of the coin: Not all mutations are good for the group as a whole with the technology we have available today. Sickle cell anemia carriers are effectively immune to malaria. Even people with sickle cell anemia don't die off until 20-40, well after the time to reproduce. So sickle cell anemia is an evolutionary advantage in places where malaria is prevalent, even if they do get killed off.

      Or as I like to think of it: If the USA were around when the Grand Canyon started, there would be no Grand Canyon. The local government would be concerned about an elevated amount of erosion. They'd contract the corp of engineers to construct a damn and sediment retainer. They'd put concrete pylons in to stop any erosion. River front property owners would keep getting bailed out by the federal government to live right next to the river.

      Sure we have these mutations, but in our desire to control everything, will anything ever come of them?

    9. Re:Not Mistakes by balbeir · · Score: 1

      Actually, nature doesn't make mistakes. It just does stuff. Some of the stuff works, some of it doesn't. The stuff that works we consider "evolved." The stuff that doesn't we consider "politicians".

      But clearly politicians are having more sex than the rest of us so they will pass their genes.

    10. Re:Not Mistakes by ConceptJunkie · · Score: 1

      Yeah, we're doomed as a species if you think about it.

      --
      You are in a maze of twisty little passages, all alike.
    11. Re:Not Mistakes by Chris+Burke · · Score: 1

      Like when Jed was out trying to shoot some food and missed, but noticed crude oil bubbling up from the bullet divot.

      Yes! An important theme flagrantly missing from the recent gritty sci-fi reboot of the The Beverly Hillbillies! In this version, the bullet that finds oil was shot right through the eye of the velociraptor Jeb was shootin' at.

      --

      The enemies of Democracy are
    12. Re:Not Mistakes by Alsee · · Score: 1

      We're even more doomed as a species if you don't think about it.

      -

      --
      - - You can't take something off the Internet! That's like trying to take pee out of a swimming pool.
    13. Re:Not Mistakes by mcgrew · · Score: 1

      In art they're called "happy accidents". In science, more important than "Eureka!" is "Hmmm, that's strange..."

      How far would physics be if that apple hadn't fallen on Newton's head?

    14. Re:Not Mistakes by mcgrew · · Score: 1

      I think your grand canyon analogy is flawed. It took millions of years for the grand canyon to form, and nobody would have noticed it happening.

  4. Bad science below. by i+kan+reed · · Score: 2

    My intuition tells me they're missing something. I've always felt that mutation rates among stressed organisms would be a lot higher than among healthy sucessful organisms. Again, intuitively, not scientifically, from a "selfish gene" perspective, an organism that generated more mutations in its offspring when it wasn't doing well would be more likely to have ANY of its genes passed on to future generations, while an organism doing well would mutate less.

    From a simpler perspective: more viruses, more bacteria, more cell damage all make mutations of some kind more likely as well. Mutations are copy-errors, and a cell under stress would be less able to error-correct its genes.

    None of this has a hypothesis I'd be willing to put out, but I think studying first world humans misses some possible independent variables.

    1. Re:Bad science below. by Mindcontrolled · · Score: 1

      From a "selfish gene" perspective, there should be an optimum regarding the rate of mutations passed on to offspring. Zero obviously has your germline severly limited in terms of adaptability, too high a number would be detrimental for obvious reasons, and further to that, as you say dilute our "selfish gene" out of existence. As usual, evolution tends to settle into local optima - "good enough" is all that it takes.

      As for the stress factor - sounds plausible on the first glance, however, stress response leads to a profound and measurable change in gene expression - upon cellular stress, genes coding for the DNA repair system tend to be expressed more strongly. So actually, mutation rate might be even lower under stress response. I don't have quantitative data at hand, though.

      --
      Ubi solitudinem faciunt, pacem appellant.
    2. Re:Bad science below. by EntropyXP · · Score: 1

      http://en.wikipedia.org/wiki/Epigenetics - DNA is big, some genes can be turned on, others can be turned off by stressors that affect the parents even in their youth.

      --
      "No one will really be free until nerd persecution ends."
    3. Re:Bad science below. by RDW · · Score: 1

      'None of this has a hypothesis I'd be willing to put out, but I think studying first world humans misses some possible independent variables.'

      They actually looked at one caucasian and one West African (Yoruba) family. A lot more will need to be analysed to see if the number of new mutations in the children are typical. The authors also recognise that "the distribution of mutation rates in the population could contain a long tail of relatively rare individuals with considerably higher mutation rates (perhaps as a result of genetic or environmental factors)".

    4. Re:Bad science below. by mcgrew · · Score: 1

      You guys referring to a "selfish gene" are thinking in binary when chemistry is analog. Rather than "selfish or empathy" and the lack of it vary as widely as intelligence or hair color. It isn't on/off. Even the "rules" we so often hear about aren't cut and dried. My ex-wife's mother had brown eyes, her dad blue eyes, hers was brown. Your eyes are blue if you get one blue gene from each parent, brown if one parent passes the brown gene. My ex-wife had a blue eyed father and a brown eyed mother. My eyes are hazel, and my daughters tell me that they could always tell what mood I was in by the color of my eyes. My oldest daughter has the deep blue eyes of my grandmother, while my youngest daughter has her mother's brown eyes -- with a twist. Her eyes change color with her mood, turning a scary looking almost red when she's angry. So apparently the recessive gene from me didn't receed completely.

      Biochemistry is far more complex than computer programming.

  5. Re:Creationists? by ciderbrew · · Score: 1

    There isn't a big enough flame bait mod point for this one and I've got all 15 sat waiting to be used. :)

  6. Re:Creationists? by Marc+Madness · · Score: 2

    I know this is probably going to go down in flames, but exactly how do creationists deal with this sort of finding? Answers from actual creationists preferred...

    It's the evolution of intelligent design: iterative design. The X-Men might actually exist had God opted for an Agile design process.

  7. Oh yeah? by Cornwallis · · Score: 1

    'We had previously estimated that parents would contribute an average of 100 to 200 mistakes to their child,'

    My parents contributed 1000s of mistakes to me...

  8. Re:Creationists? by FatAlb3rt · · Score: 1

    Well, you *did*. Best go see another thread now.

  9. Quite the opposite by sourcerror · · Score: 1

    ... the mistake is you!

  10. Re:makes sense to be by sourcerror · · Score: 4, Informative

    No!
    The main difference between you and your brother aren't mutations, but which part of your DNA you get from your mother and which part from your father.
    (I'm not a biologist/geneticist.)

  11. Mistakes by Comboman · · Score: 4, Insightful

    In terms of a DNA sequence making an exact copy of itself, yes they are mistakes (that is the very definition of a mutation). Whether that mistake turns out to be beneficial to the organism or not is a separate issue.

    --
    Support Right To Repair Legislation.
    1. Re:Mistakes by mrclevesque · · Score: 1

      Conversely they are only mistakes if the intention was a perfect copy, which I doubt.

  12. It's not bad science, it's just how evoluton works by feranick · · Score: 1

    If you do a similar comparison to computer coding, your argument is similar to saying that a mature, stable program needs less patches (mutations) and bug fixing to work, while a less mature products will require more patches. However, even for stable programs, that do their thing well, there is always space for subtle improvements (a refined interface, a new feature, support for new architectures). I think the same applies for living organism. Your definition of healthiness may not necessarily include the subtle mutations that further improve on the original. For example, again just as in computer coding, as hardware evolves, you won't need to support old and unused hardware features, and so you remove it. The same for evolved organisms: that's probably why we lost the tail and most of our fur. On the other hand, the needs of the current world to multitask and new uses for hands and brains dictated by technology, may be also influence the mutations that take place. 60 mutations isn't all that much, after all.

  13. Nature vs Nurture? by Nadaka · · Score: 4, Funny

    "Sixty mutations may sound like a lot, but according to the international team of geneticists behind the new research, it is actually fewer than expected. 'We had previously estimated that parents would contribute an average of 100 to 200 mistakes to their child"

    Don't worry, most parents are going out of their way to make up the difference and then surpass it.

    1. Re:Nature vs Nurture? by Dr.+Scatterplot · · Score: 1

      I'm consistently impressed that my would-be posts appear before I have even read the article. Clearly there are fewer variations between me and other /. readers than I had previously thought.

  14. Re:makes sense to be by dragon-file · · Score: 1

    As i understand it, when two creatures reproduce, its always a crap-shoot as to which traits come thru and which are left behind so to speak. If the father has genes A B and C and the mother has D E F and only three are need to create another human, Than the offspring could have any permeation of those three. ABE or ADF etc... The genes themselves would obviously try to copy themselves as best as possible. So it would be variance in gene selection not evolution or mutation that makes someone different than their sister. A mutation would be something along the lines of the A gene being copied as Ã.

    --
    Whenever a player quits EVE to go play WoW, the Average IQ of both games increase.
  15. N=2 by j4ckknife · · Score: 1

    I think it's woefully premature to generalize the results of this study to the entirety of humanity. These results are based off of the whole genome sequencing of *2* families, and as far as our technology and analytical methods have come, they still leave a lot to be desired. Besides, the key message isn't that we have a conclusive de novo mutation rate for humans (which we don't), but that the rate and mechanism of their creation can vary widely from family to family.

    1. Re:N=2 by j4ckknife · · Score: 1

      BTW I guess it wasn't clear from the above, but I expect that the estimate in the paper is low-balling it; the inadequacy of our methods lead to a lot of false negatives.

    2. Re:N=2 by jd · · Score: 1

      The 1000 Genome Project has mapped just over 1000 whole genomes now. To get them to map that many entire families - well, it's going to cost a bit. You are right that N is way too low to do much with, though.

      --
      It's a small world and it smells funny; I'd buy another if it wasn't for the money; Take back what I paid (SoM)
    3. Re:N=2 by mcgrew · · Score: 1

      Well, we are talking about statistics here. You may have no mutations at all, unlikely as that may seem, while my daughters probably have far more than 60 each since I was exposed to a lot of mutagens in my youth.

  16. Re:Creationists? by ciderbrew · · Score: 1

    yes, but I got meta flamehooked.

  17. Re:makes sense to be by spauldo · · Score: 1

    There is a whole lot of variation you could get from the same two parents. Each parent contributes 23 chromosomes, and which chromosome gets contributed is random. The chances of any two children all getting the same set from each parent is extremely low (outside of twins and whatnot, but that's a different mechanism).

    --
    Those who can't do, teach. Those who can't teach either, do tech support.
  18. Re:makes sense to be by blueg3 · · Score: 1

    but if parent's dna were copied exactly the same, then you wouldn't be much different from your brothers and sisters.

    This is actually because of chromosomal crossover. You receive half your DNA from each parent. Without crossover, there'd be only 4 possible children per parent pair. However, during meiosis, sections of chromosomes swap positions, dramatically increasing the number of different possible offspring.

    Still, mutation is the source of brand-new genotypes. It's critical to evolution (which is natural selection pressure applied to a population that reproduces with mutations), but it's still mutation.

  19. Re:Creationists? by Attila+Dimedici · · Score: 1, Offtopic

    A strict creationist (6 days, circa 6000 years ago in the Garden of Eden) would quite simply explain that of course mutations occur. They are a result of the first sin. The logic is somewhat complicated (although internally consistent), enough so that I will not attempt to explain the entire thought process here on slashdot.

    --
    The truth is that all men having power ought to be mistrusted. James Madison
  20. Re:Creationists? by RazzleFrog · · Score: 1, Insightful

    Creationists avoid all straight answers by just calling it "God's Will" or "God's Plan". It's a very handy catch-all bullshit answer.

  21. Re:To quote Charles Xavier by bertoelcon · · Score: 1

    That's a very groovy mutation.

    Only superpowers and eye colors are groovy mutations. Some mutations are terrible.

    --
    Anything can be found funny, from a certain point of view.
  22. Re:I will not attempt to explain by TaoPhoenix · · Score: 1

    Fermat Likes this.

    --
    My first Journal Entry ever, in 8 years! http://slashdot.org/journal/365947/aphelion-scifi-fantasy-horror-poetry-webzine
  23. Re:Creationists? by myrdos2 · · Score: 1

    But... how can mutations occur but not evolution? Do they believe that it's impossible for mutations to be passed down to your offspring?

  24. Junk DNA by jspenguin1 · · Score: 1

    Most of these mutations are in "junk", or non-coding DNA. Almost all novel mutations to functional DNA are detrimental.

    At Skepticon 3, PZ Myers gave an excellent presentation about genetic mutation and adaptation. It's about an hour long, but definitely worth a watch.

  25. Re:Creationists? by MozeeToby · · Score: 4, Insightful

    The problem is that the human brain really likes to put things into categories. That is an hamster, but that over there is not. Just because that is the way the human brain likes to work doesn't mean that it's a universal truth. Species do not exist as a phenomenon outside of the human brain. Trying to decide where one species starts and another species ends is like picking two points of the visual spectrum at random as new colors and then arguing over where one starts and the other stops. Sure, if you look at one color and then the other, you can tell that they're different, but if how do you decide where the cutoff point is? Any point you choose is going to be arbitrary because your starting points were arbitrary. The same is true for organisms.

    There are organisms which are genetically similar enough to allow for viable offspring, and organisms that are not. But even that can't magically create an immutable category, everything inside of which is a hamster and everything outside of which isn't.

  26. Re:Creationists? by rasmusbr · · Score: 2

    Simple. They claim that mutations are always harmful to the organism and it's descendants.

    When biologists show them examples of beneficial mutations happening in nature and in the lab, the creationists change their claim to that mutations are statistically speaking almost always harmful and that therefore the sum over time of mutation upon mutation will always be harmful to a population (and by doing so they prove that they don't understand the process of iterated natural selection).

    When biologists show them many examples of how species have adapted to changing environmental conditions the creationists agree that populations can mutate and develop in beneficial ways, but claim that the changes are always small and that over really long periods of time the change always gravitates around the God-given species equilibrium. The creationists call this "microevolution".

    When biologists show them examples of massive evolutionary change such as the chain of fossils of the transition from a land-living animal to whales, the creationists begin to write sophistry about "irreducible complexity" and information "theory" and claim that there's a science called "intelligent design".

    When biologists show them that irreducible complexity is not observed in nature and point out that complexity is observed to arise spontaneously in thermodynamic processes such as for example the formation of snowflakes, the creationists will surely come up with some other dumb crap. This is the stage we're at right now, so I don't know what it'll be, although a stupid idea known as "specified complexity" seems likely to become popular. These guys are completely immune to knowledge, so rest assure that there will be something new.

  27. Re:Creationists? by jd · · Score: 1

    Yes, but can you imagine the daily Scrums that would have taken place? And what if God plays by Australian Rules?

    --
    It's a small world and it smells funny; I'd buy another if it wasn't for the money; Take back what I paid (SoM)
  28. In Soviet Russia by jd · · Score: 2

    ...mistakes make you! ...as, indeed, they do everywhere else...

    --
    It's a small world and it smells funny; I'd buy another if it wasn't for the money; Take back what I paid (SoM)
  29. Re:Creationists? by Mindcontrolled · · Score: 1

    The trolls, don't feed them. You only create an environmental boundary condition that leads to the evolution of more trolls, who thrive in that particular ecological (or in this case memetic) niche. As for the GP, suffice to say that microevolution" - a concept completely made up by the creationist/ID crowd - obviously includes everything obeserved and conclusively proven to the point where you simply can't deny it. Everything outside of that, they call macroevolution. Of course, if anything previously filed under "macro" gets conclusively shown in the lab, it is re-filed under "micro": Gotta keep these goalposts moving after all.

    --
    Ubi solitudinem faciunt, pacem appellant.
  30. Re:Creationists? by kungfugleek · · Score: 2
    I'm a Creationist; an old-school bible-thumper. I think this sort of thing is genuinely fascinating and I have no problem with it, or other evidence that points to an old Earth/universe, etc. I accept the scientific evidence for what it is (that is: true according to the best of our knowledge today, and may be altered tomorrow based on new evidence), and generally believe that everything is as old as geologists say it is, and that life evolves over time because of mutations like these combined with natural selection factors. In short -- I accept what the scientific community says. My daughter is big into dinosaurs, fossils, and paleontology right now and I'm encouraging that.

    I also believe the universe and everything in it was created by an omnipotent being with a specific intent a relatively short time ago. I get that from the protestant christian Bible, and my best understanding of it.

    I intellectually manage that by remembering three things: 1) We don't know everything about the physical universe. 2) We don't understand everything in the Bible. 3) We don't really know what happens when something is created from nothing, but wouldn't it make sense that whatever is created comes into existence at a specific age? I think it's called the "Ideal Age" theory or something like that in philosophy/theology.

    I thought about that little further. If you'd seen Adam 5 minutes after he was created you'd think, "He's an adult male, probably 20-30 years old." And you'd be right. He's a 20-30 year old male that's only been around for 5 minutes. He'd bear every mark of having been born and matured like any human, because he really was an adult. If you'd look at the universe you'd say, "It's about 13-15 billion years old." And you'd be right. It's a 13-15 billion year old universe that's been around for a few thousand years, bearing every mark of a universe coming from a big bang complete with background radiation, dark matter, rate of expansion, the whole deal. Earth itself bears every mark that a 4.5 billion year old life-bearing planet would have; a fossil record, evidence of cyclic ice ages, etc, because it is a 4.5 billion year old life-bearing planet. It came into existence at that age.

    Some Creationists say that God planted the fossils and other geological evidence to "test our faith" and I don't buy that. Doing so wouldn't be consistent with what we can see of God's nature -- consistency and truth (with one or two curious exceptions in the Bible). It's not an illusion or a trick; it's reality. It looks old because it is old. I don't think the age of the universe was ever meant to test anything, except maybe the egos of the people who think they have to be right about everything in the Bible.

    But, to more directly answer the parent's post, wouldn't fewer mutations argue against evolution anyway? Don't we need, now, a lot more time for our species to evolve? And are we sure the rate of mutation has been constant, anyway? I still think it's an interesting discovery, anyway.

    Apologies for throwing fuel on what will just end up being another flame war....

  31. Re:Creationists? by MokuMokuRyoushi · · Score: 1

    Christian here. I'm answering on the basis that your question is "If humans were created not evolved into, then how do you explain this obvious evolution in humans?" I'd say... I'm no biologist, mechanical is more my thing. You tell me.

    --
    Humans are terrible replicators of Godly things.
  32. Re:Creationists? by RazzleFrog · · Score: 1

    It's not possible to be a strict Creationist AND believe in evolution unless you really believe that all this evolution happened in the last 6000 years.

  33. Rate of mutations? by grasshoppa · · Score: 1

    I wonder if the rate of mutations is higher or lower than in the past, and what it's trending.

    --
    Mod me down with all of your hatred and your journey towards the dark side will be complete!
    1. Re:Rate of mutations? by mcgrew · · Score: 1

      Considering that we are exposed to far more mutagens than our ancestors, from chemical mutagens to radiation (x-ray machines, atom bomb tests, airline travel) I'd say there are a lot more mutations than 19thy century and previous people. That said, there's no way of knowing whether my daughter being born with only one kidney is the result of my riding my motorcycle through what were later deemed "superfund sites" in my youth, or a stray neutron passing through one of my or my ex-wife's ancestors' balls.

  34. Re:To quote Charles Xavier by gmuslera · · Score: 1

    Define "terrible". For something that is the way it its because their genes ended in something that was and advantage or at least, not an impediment to survive/mate, odds are pretty high that a random change will be damaging. That it look well or bad, thats a social/cultural thing, but what defines if its good or bad is if it survives and spreads for long enough.

    Regarding superpowers, if they require not just changing one gene, but a lot to be able to work, probably should be designed instead of happening at random if we want them to ever happen.

  35. Re:makes sense to be by SomePgmr · · Score: 1

    Well, not exactly a crap-shoot...

    http://anthro.palomar.edu/mendel/mendel_2.htm

  36. source by jcombel · · Score: 1

    hijacking first thread to link the source (subscription/university login req'd), since the posted article doesn't.

  37. Re:Creationists? by MozeeToby · · Score: 4, Insightful

    No, that empirically does not work on this subject. That is how scientists around the country tried to deal with the problem for 50 years and at the end of that half century there were more people against the teaching of evolution than there were at the beginning of it. The problem is that for every troll, there is an actual creationist out there who believes what they are saying (which, IMO, makes them uneducated, but not a troll). Leaving these people to their own devices just sets them up in an echo chamber of their own misunderstandings until we end up in a situation where decision makers believe this nonsense. Then you have school boards, text book publishers, even presidential nominees who will state proudly that they don't believe in evolution. At the very least, I will voice my disagreement to make it clear that there are those who disagree, those that will hear the proud statement of a candidate's ignorance and irrevocably put them on the 'will not vote for' list.

    So please, if you see someone politely, non-aggressively stating their misunderstandings, correct them politely and non-aggressively. If it's a troll, you won't have given them the satisfaction of making you angry because you will have been polite. If it's someone who actually believes what they are saying maybe, just maybe, you'll convince them to take another look at what they believe. Even if they don't believe what they are saying, someone reading it probably does, and if you can convince just a single person to rethink the subject it is, IMO, worth the 2 minutes it took to write out a reasoned, polite response.

  38. mistakes by fahrbot-bot · · Score: 1

    We had previously estimated that parents would contribute an average of 100 to 200 mistakes to their child, ...

    Non-genetically speaking, I'm sure the number will be much higher over the kids lifetime, and I'm sure those mistakes will be far more problematic. Hopefully, mistake #1 wasn't forgetting the birth control...

    --
    It must have been something you assimilated. . . .
  39. Is there any gold there? by witherstaff · · Score: 1

    There was a recent call for the Treasury to audit the gold storage at Ft Knox. The treasury doesn't want to go along with the request.

    1. Re:Is there any gold there? by gestalt_n_pepper · · Score: 1

      Just because people are so *fussy* about the difference between gold and gold plated tungsten....

      --
      Please do not read this sig. Thank you.
    2. Re:Is there any gold there? by redemtionboy · · Score: 1

      Wouldn't surprise me. Any government agency that refuses and audit is suspect.

    3. Re:Is there any gold there? by geekoid · · Score: 1

      O few loons wanting an audit is no reason to do an audit. IF Ron Paul want's to personally pony up the money, thej fine; otherwise lets not spend 15 million for a nonsensical audit.

      He makes a crazy request,and the government giving a reasonable response is seen as some conspiracy by the same people who want the government to spend less.

      --
      The Kruger Dunning explains most post on /. http://en.wikipedia.org/wiki/Dunning%E2%80%93Kruger_effect
  40. Re:Creationists? by ukemike · · Score: 1

    Have creationists ever denied the existence of mutations?

    Actually the most common pop rebuttal of observed evolution does deny mutations. It goes like this: When a population of bacteria are exposed to an antibiotic and most die off and the remaining population reproduces which leads to a population of antibiotic bacteria it is not because of a mutation but because of already existing genetic variation.

    [sigh]Yes yes I know that argument is so flawed it isn't funny, I'm not making that argument. I'm just saying that yes some creationists do deny the existence of mutations.[/sigh]

    --
    -- QED
  41. Re:makes sense to be by dragon-file · · Score: 1

    I was just trying to get the gist across... it was easier to say crap-shoot than go into recessive vs non-recessive gene description. Especially when Biology inst my field of study.

    --
    Whenever a player quits EVE to go play WoW, the Average IQ of both games increase.
  42. Only 200 Mistakes? by general_ka.os · · Score: 1

    'We had previously estimated that parents would contribute an average of 100 to 200 mistakes to their child,'

    My parents contributed far more than 200 mistakes to this child... =)

    1. Re:Only 200 Mistakes? by mcgrew · · Score: 1

      Contributed or attributed? ')

  43. Re:makes sense to be by daemonc · · Score: 1

    of course, i'm not educated in the field, but if parent's dna were copied exactly the same, then you wouldn't be much different from your brothers and sisters.

    Yikes. You don't have to be a geneticist to understand the very most basic things about genetics - things that affect your daily life, things like "Do I share all the same genes as my brothers and sisters?"

    I remember learning about Mendel and the principles of segregation and independent assortment in 7th grade science class.

    Are you 12, or did you just sleep through that class, or has the public education system really gotten that much worse?

    --
    All that we see or seem is but a dream within a dream.
  44. bias by dala1 · · Score: 1

    Could there be some attrition bias here? Maybe the average number of mutations is actually higher, but those with more mutations are more likely to miscarry or die in childhood?

    1. Re:bias by maxume · · Score: 1

      I wouldn't think it would be very important, the interesting members of a population (re evolution) are the ones that actually reproduce.

      --
      Nerd rage is the funniest rage.
    2. Re:bias by dala1 · · Score: 1

      Right, but it could explain why the numbers they found were lower than expected.

  45. Re:Creationists? by RazzleFrog · · Score: 1

    You have a more open-minded approach but it doesn't jive with the Old Testament or current church teachings. You basically are just questioning the big bang vs some third party saying "go" and then walking away.

  46. Re:Creationists? by RazzleFrog · · Score: 1, Insightful

    And God creating something has been scientifically observed? Did I miss that on the news? You are asking to scientifically observe something that takes thousands/millions of years to happen.

  47. Re:Creationists? by jellomizer · · Score: 1

    They will probably go with flaws in the testing... Or part of Gods Intelligent Design. The Scientist are just flat out lying. Some would say this is a new phenomena due to environmental effects. That these changes are too small to be passed from generation to generations and our non-mutated cells will be dominate.
    Never underestimate the ingenuity of backpedaling an argument.

    --
    If something is so important that you feel the need to post it on the internet... It probably isn't that important.
  48. Re:Creationists? by jellomizer · · Score: 1

    That is why Intelligent Design is popular. It allows for science to show its numbers add up without having to doubt your faith.

    --
    If something is so important that you feel the need to post it on the internet... It probably isn't that important.
  49. Re:Creationists? by kanweg · · Score: 1

    "I thought about that little further. If you'd seen Adam 5 minutes after he was created you'd think, "He's an adult male, probably 20-30 years old."

    Exactly. And he'd have retrovirusses in his DNA, at exactly the same positions that chimps and bonobo's had.
    http://www.youtube.com/watch?v=TUxLR9hdorI

    And he'd have a fused chromosome, just so that it would lead big-brained people a couple of millennia later to believe that we'd actually share a common origin, because even the location where strands of DNA meet to form the familiar X-shape of chromosomes is present in his chromosome number 2. (Google for it).

    It is just in one thing you're wrong. I'm god, I created you just 5 minutes ago with all the thoughts you have. And because I'm omnipotent I took my own powers away and gave myself a bad memory (so forgive that I can't provide you with details how I did stuff, how things were and how they'll be). I thought I'd enjoy mingling with a couple of earthlings here. But I'm having second thoughts already.

    Bert

    "(that is: true according to the best of our knowledge today, and may be altered tomorrow based on new evidence)"
    Yes, altered. With science, we're moving (roughly) asymptotically to the truth. With religion, you'd never get there. Hope you didn't pick the wrong god to worship. Yesterday was Thor's day. Did you pay tribute? A tip: Today it is Freya's day.

  50. Re:Creationists? by ConceptJunkie · · Score: 1

    Well, I'm a "creationist" in that I believe God created the universe (as Aquinas' "Uncaused First Cause"), but I also happen to have no problem with the idea that He did it 14 billion years ago, may have done it or is doing it more than once, and in doing so created the means to allow evolution to happen.

    I also acknowledge that given the nature of the God it only makes sense that it is entirely possible He could have formed everything out of whole cloth 6000 years ago (on a Saturday evening in October according to Ussher), I see no reason nor evidence to believe this. In fact I would find it particularly cruel that the Almighty would endow us with such great intellect if its use only resulted in deception. In fact, I find it interesting that the so-called "creationists" aren't mired in an endless swamp of existential futility since it seems they cannot know anything because their very beliefs unequivocally infer that their senses and thought processes mercilessly lie to them.

    I know I'm not really making much of a relevant point here, I just never understood why so many people insist evolution and divine creation are considered mutually exclusive, or why so many people seem to hold the idea that God cannot and did not create a world that can be understood with our senses and intellect.

    --
    You are in a maze of twisty little passages, all alike.
  51. Re:Creationists? by RazzleFrog · · Score: 2

    Intelligent Design is a branded version of Creationism with certain things obfuscated (like who the creator was) in order to try and fool people into believing it is science. It is the lowest of the low, sleazy backhanded way of trying to trick people.

  52. Re:Creationists? by firewrought · · Score: 1

    I know this is probably going to go down in flames, but exactly how do creationists deal with this sort of finding? Answers from actual creationists preferred.

    Creationists accept that DNA mutates but reject the idea that this can lead to meaningful speciation. They distinguish between microevolution* (small inter-species changes) and macroevolution (the idea that one species can turn into another). They would see this finding as lending weight against evolution because the mutation rate is slower than what previous estimates presumably** needed to fit a certain timeline.

    Footnotes

    * The creationist use of the microevolution/macroevolution distinction is quite different from the traditional use of those terms. For creationist, the terms refer to the amount of speciation being proposed; for an evolutionist, the terms refer to the timescale or resolution being used by various approaches to studying evolution.

    ** I have no idea how the previous mutation rate was estimated, but the idea that evolutionist have to jump through hoops to adjust timelines is well embedded in young-earth creationist thinking.

    --
    -1, Too Many Layers Of Abstraction
  53. Re:Creationists? by Theovon · · Score: 2

    The creationist tenet that there is no speciation has recently been demonstrated false in fruitflies. Genetic mutations occurred that rendered two different strains unable to interbreed and produce viable offspring. On this basis, they are now two species. Since they cannot share DNA, they are bound to continue diverge significantly after enough generations have passed.

  54. Re:Creationists? by ConceptJunkie · · Score: 1

    It seems Creationists do believe that God opted for an Agile design process, whereas I believe He chose the waterfall method and had everything designed and planned out before the project was undertaken.

    If the Creationists are correct, I cannot understand what purpose He would find by making a world in which every possible bit of empirical evidence points to a history of reality which is entirely false.

    I guess that's why I could never see the point of faith without reason because creationism means His greatest and most potent endowment of human beings (our powerful intellect) serves no purpose in our knowing and serving Him. Of course, I also cannot understand how these folks, who strictly adhere to the concept of "sola scriptura," can reconcile the fact that for most of the first four centuries of Christianity there was no universally-agreed upon "scriptura" to be "sola" (and in many ways there still isn't).

    After all, if Scripture is your only basis for truth, how can you decide what is truly Scripture and what isn't? Professor Godel, call your office.
       

    --
    You are in a maze of twisty little passages, all alike.
  55. Re:Creationists? by kbolino · · Score: 1

    Are they also saying that every child is an independent act of God, not derived from either of its parents?

    If not, then they must accept that (some of) those variations--regardless of their origin--are propagated from parent to child.

    In other words, that evolution (in the strictest sense of the word) occurs.

  56. Re:Creationists? by chuckugly · · Score: 1

    I don't think creationists deny evolution per se, it's the origin of new kinds of plants and animals via evolution that is denied, or more specifically, that the variety of plants and animals we see around us now came into existence solely via evolution in the past.

  57. Are miscariages acounted for? by erice · · Score: 1

    TFA is, unfortunately, very brief and doesn't talk about this distinction but not all conceptions result in births. Embryos are often reabsorbed without the mother even being aware. I would expect the number of mutations at birth to be lower than the number at conception because those with more and more serious mutations are never born.

    1. Re:Are miscariages acounted for? by the+biologist · · Score: 1

      Miscarriages are often blamed on chromosomal abnormalities of the embryo, or defects in the mother's reproductive system.

      The 60 mutations being discussed are in the category of point mutations. Chromosomal abnormalities are so much more dramatic of a problem, that the vast majority of them result in fatal consequences before birth. It may very well be that if you have a chromosomal abnormality, you may also have a higher rate of point mutations, but they are different categories.

  58. Re:Creationists? by chuckugly · · Score: 1

    Simple. They claim that mutations are always harmful to the organism and it's descendants.

    Actually I know quite a few creationists and none of them outright deny that evolution happens, rather they do not believe that the variety of plants and animals we see around us now came into existence via the process of evolution.

  59. We are looking in the wrong areas by WindBourne · · Score: 1

    Compare this of urban to poor rural. You will find that poor rural will have a LOT more mutations and BIGGER. Why? More mosquitoes. The fact is that most mutations are caused by virus and most virus probably transmit via arthopod-bourne than any other reason.

    Sadly, these guys probably looked at fairly well to do ppl who are not just not exposed, but not around a whole lot of ppl or animals. Once they are closer to life, they will have more, faster, and bigger mutations (as in whole genes being transfered).

    --
    I prefer the "u" in honour as it seems to be missing these days.
  60. Re:makes sense to be by SomePgmr · · Score: 1

    Fair enough. It's not mine either. :)

  61. Re:makes sense to be by chuckugly · · Score: 1

    There is a whole lot of variation you could get from the same two parents. Each parent contributes 23 chromosomes, and which chromosome gets contributed is random.

    Sort of, but the arbitrary "chromosome borders" we have put up are not respected, so in fact the number of permutations is a lot higher than what the number of chromosomes would suggest.

  62. Re:Creationists? by Anonymous Coward · · Score: 1

    Well, I would consider myself an anti-creationist scientist, but what you wrote is not annoying or anything to me.

    What you wrote about is you accept reality and science and scientific process. After all, God gave us reason, so it would be a shame to spit at that creation.

    "Bible-thumpers" and religion in general will never have a problem with science and vice-versa if they don't try to contradict each other. The keyword for religion is Faith, not reality. Ideas like "afterlife" and "soul" are things that science will never touch as these ideas are based in Faith, not the scientific world.

    "He's an adult male, probably 20-30 years old." And you'd be right. He's a 20-30 year old male that's only been around for 5 minutes.

    This is a common philosophical argument about existence. It is similar to the old "tree in the forest". Another one is I perceive the world through my eyes. When I became aware, the universe was created around me. When I die, the universe dies with me. And hence each and everyone of us is the center of their own universe.

    These things are not science because they are not testable, so no problem until someone tries to say it is science. :)

    But, to more directly answer the parent's post, wouldn't fewer mutations argue against evolution anyway? Don't we need, now, a lot more time for our species to evolve? And are we sure the rate of mutation has been constant, anyway? I still think it's an interesting discovery, anyway.

    Rate of mutation is not constant because environmental pressures are not constant. For example, toxins (natural or not) or radiation ("natural" or not), or a virus, or even simply aging or breathing (or not) or lack of food all produce stress on our cells. On average you can say a large population is expected to have X amount of mutations per individual, but statistics do not apply to individuals!

    Rate of mutations is not evolution. It is part of the process, but for evolution to actually take place, a given mutation must improve or impede the survival of the organism for at least the age until they can reproduce. This selection and passing on these specific mutations is what is referred to as evolution. Most mutations are basically benign.

    There are many examples of this in nature. For example, the antibiotic resistance bacteria is one case. Antibiotic is the toxin that selects for any mutations in bacteria that cause the resistant bacteria (if it survives) to become the dominant species. Resistance is brought through mutations. These mutations are not completely random either ;) A highly stressed cell (like bacteria) will try to "activate" its "unused" DNA strands and also absorb "external DNA" into its own in hopes of finding a process to deal with the stress. This is close to its death and in vast majority of the time, it fails and dies. Sometimes it succeeds though.

    For larger animals, there are examples with Chernobyl mice living in the Red Forest (most contaminated area close to reactor). There is still large background radiation dose (from contamination) and mice were discovered living quite happily in that environment. To test if same species of mice from "outside the zone" would survive, some mice were trapped from Chernobyl and regular mice were placed in a cage close to them for a few weeks in the Red Forest. The "imported" mice did not do very well. The local mice were quite happy, as expected. Later it was determined that the Chernobyl mice have mutated to drastically increase their DNA repair mechanisms to cope with much higher radiation levels.

    This is how evolution works. Mutation + natural selection leads to evolution. Mutation alone does nothing. This is why evolution is not survival of the fittest. Evolution is survival of most adaptable to changing conditions.

    I would like to add that humans, as a species, have almost stopped evolving because natural selection no

  63. Re:makes sense to be by DahGhostfacedFiddlah · · Score: 1

    Yes and no.

    I'd say the main difference is in which parts came from each grandparent. You inherit one of each chromosome from both mom and dad, but the chromosome is a random(ish) combination of their parents. The recombination of DNA doesn't occur until the sperm/egg are created.

  64. I had too many. :( by antdude · · Score: 1

    Nager's Syndrome. :(

    --
    Ant(Dude) @ Quality Foraged Links (AQFL.net) & The Ant Farm (antfarm.ma.cx / antfarm.home.dhs.org).
  65. Re:Creationists? by xehonk · · Score: 2

    It's not quite that simple. See ring species for one example where that categorization breaks down.

  66. Re:Creationists? by Attila+Dimedici · · Score: 1

    Well, I suppose they would agree with that, if you define evolution as creatures gradually becoming worse. I do not know of any creationists who deny that species change over time. What most creationists deny is that speciation (the development of new species from old) occurs.

    --
    The truth is that all men having power ought to be mistrusted. James Madison
  67. Re:Creationists? by RazzleFrog · · Score: 1

    Who in the world talks about Darwinism anymore? What century are you living in? Contrary to religion - science adapts and changes based on the latest and greatest information.

  68. Re:Creationists? by GameboyRMH · · Score: 1

    I'm not a creationist but when I debated this point with one, he started to divide things into "micro-evolution" (a few minor changes) and "macro-evolution" (the collective effect of many mutations that would lead to changes as significant as a species change), and said that "micro-evolution" had been observed while "macro-evolution" hadn't (please ignore all fossil records, every single minor change in every species hasn't been documented after all!), and therefore GAAWWD could have intervened in cases of "macro-evolution."

    They'll just keep jamming God into the bigger gaps as the smaller ones are closed.

    --
    "When information is power, privacy is freedom" - Jah-Wren Ryel
  69. Re:Creationists? by RazzleFrog · · Score: 1

    You can't use scientific evidence that Creationists believe is false and made up to prove a point about Creationism. Either you accept science or you don't.

  70. Re:makes sense to be by bberens · · Score: 1

    It's not that the public education system doesn't teach these things. It's that it's incredibly boring to most people so they don't remember it. I'm sure there's plenty of things you learned in school that bored you that you don't remember. A trivial example for me is that I cannot confidently name all the states and capitals in the U.S. even though I memorized that for tests in school. That's just a piece of trivia that I found boring and useless so it's not something I can recall easily.

    --
    Check out my lame java blog at www.javachopshop.com
  71. Re:Creationists? by GameboyRMH · · Score: 1

    Good to know! I'll have to find a scientific paper on this and show it to a creationist to see what they come up with next.

    --
    "When information is power, privacy is freedom" - Jah-Wren Ryel
  72. Evolution is not a "mistake" by Kalle+Barfot · · Score: 1

    Quote: '... actually much fewer mistakes, or mutations, are made.'

    This is a very wrong statement. Mutation is a basic natural process, a normal occurrence during reproduction. That's how DNA works! To call it a "mistake" is idiotic and implies some entity somehow "preferred" no mutation ever.

    --
    "To strive, to seek, to find, and not to yield." -- Tennyson
    1. Re:Evolution is not a "mistake" by geekoid · · Score: 1

      No, not idiotic. In this Context: mistake = Not an exact copy.

      --
      The Kruger Dunning explains most post on /. http://en.wikipedia.org/wiki/Dunning%E2%80%93Kruger_effect
    2. Re:Evolution is not a "mistake" by Kalle+Barfot · · Score: 1

      One more time: mutation is a normal, regular part of reproduction. Using the word "mistake" to describe mutations is a complete misunderstanding of the nature of biological processes.

      --
      "To strive, to seek, to find, and not to yield." -- Tennyson
  73. Mutant and Proud. by BLToday · · Score: 1

    The only mutant powers I really want is the one from Philip K. Dick's "The Golden Man". http://en.wikipedia.org/wiki/The_Golden_Man

    1. Re:Mutant and Proud. by MonsterTrimble · · Score: 1

      Mine is to be able to transfer heat energy from one object to another quickly. Then I can punk the Human Torch & Iceman at once.

      --
      I call it 'The Aristocrats'
  74. Re:Creationists? by RDW · · Score: 1

    "Also, for you developers out there...can you imagine what would happen to your code if someone started randomly flipping bits in your machine's memory? Would it produce new, useful features? Of course not!"

    http://en.wikipedia.org/wiki/Mutation_(genetic_algorithm)

  75. Re:makes sense to be by spauldo · · Score: 1

    Cool. Learn something new every day, I guess.

    --
    Those who can't do, teach. Those who can't teach either, do tech support.
  76. Re:Creationists? by geekoid · · Score: 1

    1) We don't know everything about the physical universe. 2) We don't understand everything in the Bible. 3) We don't really know what happens when something is created from nothing,

    1) So? not nowing everythign does not mean anything is possible. Every tst for God has come up negative.

    2) Yes actually, we pretty much do. Well, those of us who have studied it's history. There are a few minor interpetation points based on culture, but like I said, they are inor differences regardless.

    3) That's impossible. No one says something was created from nothing except people who believe in magic.

    " I don't think the age of the universe was ever meant to test anything, except maybe the egos of the people who think they have to be right about everything in the Bible."

    The bible in no way indicates the age of the earth. It's a complete fallacy and biblical ignorance to say so.

    According to the myth Adam and Eve descendants where marked so they would be different then the others..what others? Wait, it's an allegory so it doesn't matter.

    Creating a myth specifically to be non provable means it's not science, so it should stay the hell out of science discussions and stick with philosophy.

    "st, wouldn't fewer mutations argue against evolution anyway?"

    A) there is no argument. Evolution is real and a fact. Just as solid as gravity or germs.

    B) We didn't know how many, now we know. There could have been 1 mutation and that still wouldn't have 'disproved' evolution, simple a refinement on what we know.

    --
    The Kruger Dunning explains most post on /. http://en.wikipedia.org/wiki/Dunning%E2%80%93Kruger_effect
  77. "germ cell" mutations not somatic mutations by peter303 · · Score: 1

    Germ cells are the sperm and eggs which are pretty hardwired in sperm stem cells or ovaries by birth. The non-germ somatic cells which make up the vast majority of your body continue to mutate through your pre-birth development and post-birth life. Cancer is thought to be the accumulation of 5 to 20 such mutations or expression changes in somatic stem cells. This cancer hypothesis should be better known in next decade or two as researchers are furiously sequencing cancer cells to see how they have changed.

  78. Re:Creationists? by geekoid · · Score: 1

    Because people are screwing with science to force there incorrect belief down everyone's throat, that's why.

    IF God created the world, then he is outside nature. So science doesn't apply. When people start making stuff up that there God impacts the real world, it can be tested and evaluated. IN those case it has always been found false.

    SO keep your God, but stop trying to dictate science.

    --
    The Kruger Dunning explains most post on /. http://en.wikipedia.org/wiki/Dunning%E2%80%93Kruger_effect
  79. Re:makes sense to be by geekoid · · Score: 1

    (I'm not a biologist/geneticist.)

    I gathered that from your post.

    --
    The Kruger Dunning explains most post on /. http://en.wikipedia.org/wiki/Dunning%E2%80%93Kruger_effect
  80. Re:Creationists? by rasmusbr · · Score: 1

    You're right that science and religion can coexist so long as religion agrees to move out of they way when it comes into conflict with science and science has evidence and religion doesn't. That does make your God a bit of a God of the gap, but maybe that is not a problem. Things like "how can we make nature do our bidding?" are by their nature answered by science. Any God worth his salt should be able to answer them, but there's no reason why he should give us the answers on a silver platter.

    The reason why I'm not religious is not so much due to the success of science in answering questions about nature as due to the failure of religion to answer questions about ethics and aesthetics and yes - the failure to explain the beginning of the universe/multiverse/cosmos (if it had a beginning). The God hypothesis does not seem to explain anything.

  81. Re:Creationists? by Black+Parrot · · Score: 1

    But... how can mutations occur but not evolution? Do they believe that it's impossible for mutations to be passed down to your offspring?

    The two most common rationalizations are:

    1) mutations happen, but not beneficial ones.

    2) microevolution happens, but no amount of it adds up to macroevolution.

    --
    Sheesh, evil *and* a jerk. -- Jade
  82. Re:Creationists? by Black+Parrot · · Score: 1

    Some Creationists say that God planted the fossils and other geological evidence to "test our faith" and I don't buy that.

    It's funny that those people who think fossils are a prank God is pulling on them won't consider for a moment that Genesis is a prank that God is pulling on them.

    --
    Sheesh, evil *and* a jerk. -- Jade
  83. Re:Creationists? by Black+Parrot · · Score: 1

    Then a question occurred to me. If a god created the universe, who created the god?

    God's God.

    It's Gods all the way up, you know.

    --
    Sheesh, evil *and* a jerk. -- Jade
  84. Re:makes sense to be by Alsee · · Score: 1

    You receive half your DNA from each parent. Without crossover, there'd be only 4 possible children per parent pair.

    That "4 possibilities" applies for each chromosome-pair that is inherited. Humans inherit 23 chromosome-pairs, each of which multiplies the number of combinations by 4. So even without considering the possibility for crossover, the number of different possible children works out to over 70 trillion.

    -

    --
    - - You can't take something off the Internet! That's like trying to take pee out of a swimming pool.
  85. Re:Creationists? by ConceptJunkie · · Score: 1

    But the purpose of religion is not tell us the whats and hows of the working of the world, so as a believer _and_ a big fan of science, I have no problems with that. It's not that religion fails to do what science does, but that religion answers a different set of questions. Science has also failed to answer the questions that religion addresses.

    --
    You are in a maze of twisty little passages, all alike.
  86. Re:Creationists? by ConceptJunkie · · Score: 1

    Yeah, but people are screwing with science for other reasons all the time, too (like politics). Science will survive that as well.

    --
    You are in a maze of twisty little passages, all alike.
  87. Re:Creationists? by ConceptJunkie · · Score: 1

    Maybe that's why He's a Trinity... so the meetings aren't so boring. ;-)

    --
    You are in a maze of twisty little passages, all alike.
  88. Some have 65 more... by Eric+Damron · · Score: 1

    I understand that country western music listeners have an average of 65 mutations...

    --
    The race isn't always to the swift... but that's the way to bet!
  89. Re:makes sense to be by Alsee · · Score: 1

    It's not that the public education system doesn't teach these things.

    Actually anything related to biology and evolution is a bit of a special case in that most high schools in the United States fail to teach a decent basic understanding of the subject. It's a very regional thing. Some parts of the country on usually do teach it, and other parts are abysmal. In some cases school boards, principals, and "science" teachers actively subvert the subject pushing anti-science creationist misunderstanding. And in all too many other cases, school boards, principals, and individual teachers gloss over biology or avoid it entirely to avoid the problem of irate clueless parents who come in screaming against it.

    -

    --
    - - You can't take something off the Internet! That's like trying to take pee out of a swimming pool.
  90. Re:Creationists? by rasmusbr · · Score: 1

    Yes, that's what I'm trying to say. I don't want religion to try to explain science (I mean, I suppose I would be okay with it if God wanted to explain everything). I want religion to explain things that aren't explained by science and the non-religious parts of philosophy. If religion can sort of uniquely explain anything then I will be satisfied and I will probably join it, but I don't think it does.

    Religion addresses ethics, but it fails to arrive at answers. The failure goes back to the age-old question about whether or not God has the power to decide what's good and what's bad. If the answer is no, God is not really God. If the answer is yes, God is asking you to basically follow his whims.

    Why would you follow the whims of God? I mean I think we need rewards and punishments in place if we're going to follow orders. I think that's why religion needs heaven and hell (and similar ideas like rebirth and nirvana and whatnot) to make sense of ethics. You can decide to not follow God, but that's going to suck for you. A believer in a savior God could paraphrase "science - it works, bitches" with "savior God - it works, bitches... You'll have to wait until you die, but it really works. Promise."

    The problem with that is that if the mind is the brain, then God would have to make a copy of the information in the brain to transfer it to your new avatar in heaven or hell. Then we would expect there to be a physical copying event of the mind-state right before a person dies. But we don't see that. It could be we're not smart enough to see it. Could be that the mind isn't really the brain, except it looks like it is.

    I tend to think that religion has evolved in a Darwinian process that selects for beliefs that maintain social cohesion and strengthen societies.

    I'm not telling anyone to quit religion. There is evidence that religion can be a good way to keep in touch with your community and your extended family. There are lots of nice traditions, some of which I follow myself, just because I like to. I think that telling someone to quit religion cold turkey and replace it with science is a bit like telling someone to quit Facebook and replace it with Wikipedia.

  91. Re:Creationists? by toriver · · Score: 1

    Ask them what Adam's hair, skin and eye colors were. Ask them where all the other variants among humans come from.

  92. Re:Creationists? by mcgrew · · Score: 2

    You've posted in this discussion so your mod points are no good here.

  93. Re:Creationists? by mcgrew · · Score: 2

    The answer is simple. A recent study (did I see it here?) showed that bible literalists and athiests have smaller hippocampuses than agnostics, protestants, and Catholics. There's no point in arguing with someone who has a shrunken hippocampus.

    Unless God has evidenced himself to you, the only logical choice is agnosticism, since there can be no proof one way or the other. Keep in mind that once you've seen an elephant you can't disbelieve elephants existance. "You're crazy, you just hallucinated that elephant! Was it pink?"

  94. Re:It's not bad science, it's just how evoluton wo by mcgrew · · Score: 1

    I think where your analogy falls down is that all genetic mutations are coding errors, whether beneficial or not. It would be more like a computer bug caused by a typo in the programmer's code that made the program calculate faster. I don't, however, remember ever personally running across a bug like this in my own code...

  95. Re:makes sense to be by mcgrew · · Score: 1

    Not always. Recessive genes are passed on but don't express themselves. If you have one gene for blue eyes and one for brown eyes your eyes will be brown. Two brown eyed people can produce a blue eyed child, since each parent could carry one blue and one brown. If both your parents have blue eyes and you have brown eyes, your father is not your biological father.

    Gene selection doesn't cause evolution, except when a genome dies out. Evolution is caused by a beneficial mutation. Humans didn't get their big brains from a random shuffling of genes, there was a mutation in one or probably more pre-humans that made staying alive and reproducing more likely.

    Look at it this way -- if your mother has two genes for normal sized genitalia and your biological father has genes for small genitalia, the only way you;ll have a twelve inch dick is a genetic mutation. You can't mix salt and water and get chlorine.

  96. Re:makes sense to be by mcgrew · · Score: 1

    Sure it is, but it's a crap shoot with huge dice with billions of faces, some of which can spontaneously change the number of spots (mutation).

    I actually was as surprised as the researchers that there weren't more mutations, considering all the mutagens in the environment, from chemicals to solar radiation.

  97. Re:makes sense to be by mcgrew · · Score: 1

    That's what I come to /. for. Well, that and the nerdy jokes.

  98. Re:makes sense to be by mcgrew · · Score: 1

    I was bored in school because everything they tried to teach I'd already read. I'm sure I'm not the only slashdotter like that. College was different, though, I actually learned in college.

  99. Re:Gosh, some editing would be nice by mcgrew · · Score: 1

    Note that my submission was completely changed; the only thing that stayed the same was the link.

  100. Re:makes sense to be by mcgrew · · Score: 1

    Part of the problem is science majors teaching math and math majors teaching literature.

  101. Re:Creationists? by ukemike · · Score: 1

    Odd that I got modded down for "flamebait." This was an early post in the discussion, and it utterly failed at actually attracting any flames. In fact of the two replies one was a clever joke and the other was a furtherance of my argument. Perhaps the modder made a slip of his mouse and accidentally selected "flamebait" when he was trying to select "I disagree."

    Unfortunately I find this to be typical of Christians engaged in debate. When rhetorically cornered they resort quickly to one of three canned responses: "it's a matter of faith," "you must have so much pain inside to be so resistant to seeing the light," and yelling to drown you out. I think this falls into the yelling category.

    --
    -- QED