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Why Are the World's Scientists Continuing To Take Chances With Smallpox?

Lasrick writes: MIT's Jeanne Guillemin looks at the recent blunders with smallpox and H5N1 at the Centers for Disease Control and the National Institutes of Health to chronicle the fascinating history of smallpox eradication efforts and the attempts (thwarted by Western scientists) to destroy lab collections of the virus in order to make it truly extinct. "In 1986, with no new smallpox cases reported, the World Health Assembly, the decision-making body of the WHO, resolved to destroy the strain collections and make the virus extinct. But there was resistance to this; American scientists in particular wanted to continue their research." Within a few years, secret biological warfare programs were discovered in Moscow and in Iraq, and a new flurry of defensive research was funded. Nevertheless, Guillemin and others believe that changes in research methods, which no longer require the use of live viruses, mean that stocks of the live smallpox virus can and should finally be destroyed.

190 comments

  1. They need it... for duck huntin' by Anonymous Coward · · Score: 0

    Futurama reference. See also, mutated anthrax.

  2. Same reason we keep developing nuclear weapons by Anonymous Coward · · Score: 1

    Humanity will never stop playing with fire. It's built into our brains. And as long as some person, somewhere, somehow, has access to smallpox samples, scientists will continue studying it for "defensive research."

    1. Re: Same reason we keep developing nuclear weapons by Anonymous Coward · · Score: 0

      Agreed to some extent.

      Now imagine that you hold on your hand the only vial of smallpox in the world. How powerful do you feel now?

    2. Re: Same reason we keep developing nuclear weapons by Anonymous Coward · · Score: 2, Interesting

      Smallpox is a terrible disease for sure, but is not a good candidate for biological warfare. The reason why scientists keep it alive has nothing to do with war for a change; they keep it alive because if was a very successful virus and understanding the reasons of said success may be beneficial in the future.

      Sure, we can play safe and kill it based on flawed emotional responses but first, there is no guarantee that destroying the known samples will kill every existing reservoir, second: not having a sample will produce a slower response (and more dead and maimed children) if a variant of the virus emerges from somewhere else and finally we are discarding any positive application of the virus (like using a harmless mutation to carry a payload targeting cancer cells or similar)

      Also, notice that even if the virus as it is somehow escapes or is intentionally released, it is relatively easy to detect and cure.

      All in all, the benefits of keeping it alive for future research overweights the risks... the worst case scenario is a weaponized smallpox intentionally released in a civil population, but even in that case you WANT to have it somewhere to speed the development of a vaccine.

    3. Re: Same reason we keep developing nuclear weapons by kencurry · · Score: 1

      "my precious...."

      --
      sigs are for losers (except to point out that sigs are for losers)
    4. Re:Same reason we keep developing nuclear weapons by Triklyn · · Score: 2

      ... fire is a damn nice thing to have. cooking is good, boiling is good. combustion is good. the steam engine is good. coal is good. petrol is good... fire is life.

    5. Re:Same reason we keep developing nuclear weapons by idontgno · · Score: 1

      No, fire bad. Bread, gooood.

      Cite

      --
      Welcome to the Panopticon. Used to be a prison, now it's your home.
    6. Re: Same reason we keep developing nuclear weapons by zwarte+piet · · Score: 1

      Should be worth something on e-bay

    7. Re: Same reason we keep developing nuclear weapons by Anonymous Coward · · Score: 0

      Hey, you didn't pack that vial well enough at all! FFF---------!

    8. Re: Same reason we keep developing nuclear weapons by kwbauer · · Score: 1

      Very powerful. And smart enough to realize that I am probably not holding the only remaining vial. That is exactly why the American researchers were reluctant to destroy their samples. They were soon proven wise when it turned up in Russia and Iraq.

    9. Re:Same reason we keep developing nuclear weapons by Anonymous Coward · · Score: 0

      I have some reservation relating to steam engine and all that came from and after it...

      I see the irony of writing such a thing on an internet forum. But the pandora box is open and is not going to close down, so, non contradiction really.

    10. Re:Same reason we keep developing nuclear weapons by Triklyn · · Score: 0

      inarguably good, unless you're a new-age hippie... in which case, give back the medicines and go retroactively have a 30 percent chance of dying in infancy.

  3. The problem is... by Lab+Rat+Jason · · Score: 4, Insightful

    ...you can't possibly guarantee the destruction of every sample. We have lax tracking policies to thank for that. If we voluntarily destroy all our live samples, and some other nation doesn't, then you can bet your next paycheck someone will use that as a weapon against us and we'll be totally powerless to retaliate (or so goes the argument).

    --
    Which has more power: the hammer, or the anvil?
    1. Re:The problem is... by guises · · Score: 5, Informative

      That is not the argument. I don't know what the argument is, but it can't be that - it doesn't make any sense. If we voluntarily destroy all our samples, and some other nation doesn't, then there will be that much less smallpox. This is a valuable goal in itself, even if it doesn't mean that the virus has been completely eradicated.

      No one who wasn't literally insane would try to use smallpox as a weapon, the infection would inevitably spread back to the country which initiated it, and the idea that we would need samples of our own to retaliate is preposterous. For one thing, the entire premise of this scenario is that this other country has just given us all the samples that we could possibly want. For another, we still have tons and tons of missiles and bombs just sitting there, looking for a way to justify all of the money that we paid for them.

    2. Re:The problem is... by jbolden · · Score: 1

      I agree that GP's point is silly. Btt we probably would need smallpox and and smallpox research to construct a vaccine against a weaponized smallpox. I remember after 9/11 how scared everyone was about weaponized anthrax, but at least we understood most everything about how anthrax operates.

    3. Re:The problem is... by Anonymous Coward · · Score: 0

      We spend more than the rest of the world combined on our military, we don't need smallpox to retaliate.

    4. Re:The problem is... by fche · · Score: 1

      "If we voluntarily destroy all our samples, and some other nation doesn't, then there will be that much less smallpox. This is a valuable goal in itself,"

      Do you support unilateral disarmament too?

    5. Re:The problem is... by Anonymous Coward · · Score: 0

      The M.A.D. argument only works when you can guarantee the next dictator of your country isn't going to use it just because s/he thinks all the other countries are ganging up on him/her when /she is insanely power hungry and can't see the country's own poor people are being murdered by the police and imprisoned at the highest rate in the world, cough cough (don't look at those numbers USA citizens). Or I guess you can always justify killing other people in other countries more than feeding the starving people back home, especially when the biggest campaign kickbacks come from friends in the military industrial complex.

      You have to be insane to think any country in the world should be allowed to use an indiscriminate killing weapon, robot, bomb, or humans who have been brainwashed to kill. That's the argument against M.A.D., that anyone arguing for it is truly insane because they are supporting the ideology of indiscriminate murder of an unlimited degree as a defense.

      As most wars are started by dictators or a few people who have political power ambitions and no real involvement in the fighting of the wars anymore, I'd argue any country's politicians should be the first ones required to be on the battle field if they are supporting the active aggression into wars. That would decrease the number of idiots in the world, especially the political ones.

      It may work with nuclear weapons because of how fearful people of out being killed by one bomb but the truth is that there are far more dangerous things if you look at how many people have died from Smallpox, it is one of them at ~300,000,000 deaths in the 20th century alone.

      Nuclear bombs only killed 220,000 people. More people die from car accidents, 1,240,000 globally, than that.

      So, the argument is why do we allow any scientist, country, or military to keep live samples?

    6. Re:The problem is... by Anonymous Coward · · Score: 1

      No one who wasn't literally insane would try to use smallpox as a weapon, the infection would inevitably spread back to the country which initiated it, and the idea that we would need samples of our own to retaliate is preposterous.

      You make two major assumptions that do not meet observed human behavior.

      1) All factions capable of growing a weapon-scale batch of smallpox value civilians in their own area of control. -- Given the number of despotisms that actively starve the local populace so they can sell the UN aid supplies and amass luxuries, this is an unfounded belief.
      2) Factions that would consider using smallpox would not make an effort to have at least enough vaccine ready for the ruling class. -- And this is also related to the real argument for keeping some around. It isn't about throwing some back at the enemy, it's about having some already isolated to skip a couple steps in preparing vaccines.

    7. Re:The problem is... by bigfinger76 · · Score: 2

      So, the argument is why do we allow any scientist, country, or military to keep live samples?

      Who is this we?

    8. Re:The problem is... by structural_biologist · · Score: 3, Interesting

      We have had the ability for quite some time to synthesize viruses from scratch (the first report in the scientific literature came from the laboratory of poliovirus from scratch, published in 2002). So, there is no reason to keep smallpox stocks around because we can just synthesize the virus if we need it. While this technology means that anyone with sufficient resources could download the (publically available smallpox genome, and synthesize it, the same technology also enables scientists to more rapidly generate vaccines without having to start with a physical sample of the virus.

    9. Re:The problem is... by aix+tom · · Score: 1

      But the "beauty" of sending smallpox as a weapon is that it could be done in a way that the source is unknown. Having your own samples isn't really useful for retaliations, but it could be useful for creating vaccines quickly to contain the outbreak.

    10. Re:The problem is... by Jane+Q.+Public · · Score: 5, Insightful

      No one who wasn't literally insane would try to use smallpox as a weapon, the infection would inevitably spread back to the country which initiated it, and the idea that we would need samples of our own to retaliate is preposterous.

      Yes, the point is that it's like MAD and other weapons policies: you don't want to put down your gun (or shield, for that matter) while the other guy is still holding on to his. Despite what many people say, that is completely sane and rational behavior.

      The thing OP kind of sidesteps is that while Western countries countries resisted complete eradication, they did so openly. Only later it was discovered that other countries (most of which were supposedly in favor of the eradication program) kept their own samples and research anyway. Which is a perfect illustration of why the West wanted to hang on to theirs, too.

      It's easy enough to call such policies insane, but nobody wants to be the only "sane" person in the room while all the nutjobs still have their weapons. That kind of disproves it would a sane approach, yes?

    11. Re:The problem is... by blue9steel · · Score: 1

      No one who wasn't literally insane would try to use smallpox as a weapon, the infection would inevitably spread back to the country which initiated it

      Yes, because there aren't any insane people around who carry a grudge against us.

    12. Re:The problem is... by guises · · Score: 1

      The point that I was trying to make is that comparing smallpox to a gun, or even a nuclear weapon, isn't accurate. Using smallpox as a weapon is MAD even if you're the only one using it. The purpose of pointing a gun at another armed person is the idea that if you shoot him first, and do it thoroughly enough, he then won't be able to shoot you. That is not the case with smallpox.

      Having live samples available is also not needed or useful for producing the vaccine. The only argument that I've heard in favor of keeping some samples around which isn't totally loony, and this is a recent development, is that genetics manipulation has reached the point where artificially creating something comparable isn't insurmountably difficult anymore. So smallpox is less of a threat, basically by obsolescence. As this is a recent state of affairs however, this does not justify holding onto it as they have for the last few decades.

    13. Re:The problem is... by Anonymous Coward · · Score: 2, Interesting

      It depends. Smallpox is not the best example, but the ideal virus to use as a biological weapon is a virus with long, mostly asymptomatic infectious phase and a high mortality rate. A virus with those characteristics could infect a large portion of the population before detection and basically wipe it out before effective measures can be taken (typically the first to fall to the infection are the first responders, nurses and MDs and chances are that by the time of the risk is apparent you won't have any effective personnel to deal with it)

      Also, a weaponized virus is not necessarily invulnerable to treatment (that would make it too dangerous to handle), to be effective as a weapon is more than enough to require some sort of unusual treatment; if it manages to infect a large portion of the population before detection, the existing inventories of the treatment won't be enough to deal with it and by the time the logistics for production and distribution of the treatment are in place, the population will be most likely decimated.

      Finally, there are people insane enough to invest time and money to develop biological weapons, the US government being the primary offender to date (google is your friend). A virus like in the scenario I describe is a "coward's weapon" to be used once on an unsuspecting population, not something you put in a warhead and launch in a war zone. For starters, is not meant to target enemy combatants, but an entire population, so using it is both a war crime and a crime against humanity and no nation would want to risk getting caught using it in the open. Thats why the most likely scenario is the use of intelligence services to start the epidemic by infecting a few unsuspecting civilians in an hostile nation (thats highly unlikely to leave any traces about the origin of the disease)

      Sadly, if history serves as evidence, said methods are not beyond what our dear politicians are capable of.

    14. Re:The problem is... by Lab+Rat+Jason · · Score: 1

      Yes, I was being facetious... giving voice to the people who hang on to this crap for no good reason.

      I'm mostly just astounded by the fact that our government... who knows EVERYTHING... doesn't know where they are keeping their deadly viruses... even if they aren't weaponized.

      But hey... nobody ever accused the US government of being efficient.

      --
      Which has more power: the hammer, or the anvil?
    15. Re:The problem is... by aevan · · Score: 1

      Next SciFi movie special: Having a crisis of morality, a technician at a biological research facility attempts to destroy the last samples of a virulent strain. Improperly doing so, an ancient plague is revisited upon the world. Can a small town sheriff, his plucky daughter, and the random love interest survive this new apocalyptic world?

    16. Re:The problem is... by Anonymous Coward · · Score: 0

      > No one who wasn't literally insane

      I'm not worried about the ones that are sane. However, the ones that are insane form governments and military.

    17. Re:The problem is... by Oligonicella · · Score: 3, Insightful

      Still doesn't justify keeping it around. We *have* a vaccine. We also have nukes, so retaliation by smallpox isn't necessary.

    18. Re:The problem is... by Grog6 · · Score: 1

      Large numbers of people in the US were vaccinated for smallpox in the 60's; pretty much everyone over 50 or so.

      Not so now or anywhere else, either. :)

      --
      Truth isn't Truth - Guliani
    19. Re:The problem is... by ultranova · · Score: 1

      Do you support unilateral disarmament too?

      Smallpox isn't a weapon. Smallpox is a disease. Should someone be stupid enough to re-introduce it to the world, it will circle back and hit them, too. So the only thing destroying live smallpox samples does is reduce the chances of a catastrophic screw-up.

      --

      Forget magic. Any technology distinguishable from divine power is insufficiently advanced.

    20. Re:The problem is... by Anonymous Coward · · Score: 0

      Smallpox doesn't kill people right away. If someone uses smallpox as a form of weapon the ones they used it on have plenty of smallpox available to retaliate with if they haven't retaliated with more efficient means.

      Possibly it can be used by "terrorists" if they just want to cause a massive scare without doing massive damage. Retaliating with the same means would just mean spreading smallpox to innocents.
      As a form of weapon smallpox have no defensive purpose nor does it act as a deterrent.

    21. Re:The problem is... by Anonymous Coward · · Score: 0

      Ugh... biological weapons are murdering indiscriminately: elderly, children, babies and other non-combatants; no control over collateral damage.
      I would refuse to wage such disgraceful war even as retaliation; not to even mention that it endangers your own population as you would need to vaccinate everybody.

    22. Re:The problem is... by fche · · Score: 1

      "Smallpox isn't a weapon."

      We're not talking taxonomy, we're talking possible utility.

      "So the only thing destroying live smallpox samples does is reduce the chances of a catastrophic screw-up."

      No, it also reduces the ability of labs to experiment on & learn from the thing.

    23. Re:The problem is... by jbolden · · Score: 1

      I'm saying use it for vaccines against weapons not MAD.

    24. Re:The problem is... by Anonymous Coward · · Score: 0

      Obviously YOU and the rest of humanity that doesn't give a fuck what a bunch of military drones, scientists, and everyone else does when it comes to stuff that might kill oodles of people if someone forgets to close a container or lets some files slip into the wrong hands.

    25. Re:The problem is... by IronChef · · Score: 1

      Find out in... POXPOCALYPSE!

    26. Re:The problem is... by Anonymous Coward · · Score: 0

      They don't know jack shit or john shit for that matter, it's a shit ass pile of data they don't even know what they are looking for in it - hence why they can't stop any shit from happening.

      I at least get to debate and decide the fate of humanity by deciding on how to develop a technology that is far more weaponizable than any virus or fungus, but I only want to develop it as a peaceful energy technology. The problem is that it too much of a weapon and makes all the other weapons the militaries have look like toys, yes even their big shit bums that they drop on shitty people.

      The US government is supposed to be the people of the US, except they hide what they do so much that **there is no representation** for the tax dollars they use to fund that hidden shit.

      The problem is that humanity isn't exactly looking ready for the next energy revolution that will likely kill us all anyway...

    27. Re:The problem is... by Anonymous Coward · · Score: 0

      Retaliate? No, I think they're worried about not being able to DEFEND.

      This stuff is horrible but it can be used to make vaccines, etc.

    28. Re:The problem is... by s.petry · · Score: 2

      Except that Smallpox is not a WMD, so "weaponized" smallpox is not a deadly disease if the person who contracted it receives very _basic_ medical treatment.

      As an educated guess, the study into smallpox has been to figure out out why it is so contagious so that we can build our own great contagion. Merge the contagious properties of smallpox with the payload of Ebola and then you have a weapon.

      Sad that we spend so much money learning how to kill each other instead of figuring out how to advance society, but this is the reality that people continue to buy in to.

      --

      -The wise argue that there are few absolutes, the fool argues that there are no probabilities.

    29. Re:The problem is... by jbolden · · Score: 1

      Ebola is a bacteria. But AFAIK that's the basic idea, merge genes of different viruses to create better forms of smallpox. That's what the samples are for to be able to create vaccines.

    30. Re:The problem is... by bloodhawk · · Score: 2

      did you not even read the summary let alone the article? we don't need LIVE small pox virus anymore to produce vaccines or perform research. Should someone use it as a weapon then obviously we would have an abundant supply of the live virus anyway.

    31. Re:The problem is... by idontgno · · Score: 3, Informative

      Ebola is a bacteria

      Whaaaaaa?

      --
      Welcome to the Panopticon. Used to be a prison, now it's your home.
    32. Re:The problem is... by jbolden · · Score: 1

      OK I stand corrected. Thank you.

    33. Re: The problem is... by expatriot · · Score: 1

      But as it can be synthesised, that refutes the argument that "if we destroyed it, it would be gone forever"

    34. Re:The problem is... by Anonymous Coward · · Score: 0

      Only if you didn't vaccinate your population first before releasing the virus.
      Studying viruses, especially those that cause disease in humans, helps us understand how our immune system works and how to better defend against new public health threats.

    35. Re:The problem is... by oobayly · · Score: 1

      They don't know everything - they just know whether you prefer Burger King or McDonalds, and that you lied to your friends about how pretty your girlfriend is.

    36. Re:The problem is... by msauve · · Score: 1

      "Except that Smallpox is not a WMD, so "weaponized" smallpox is not a deadly disease "

      Whoosh.

      The most effective weapons don't kill, but make the opponent expend resources which might otherwise be used in the battle.

      --
      "National Security is the chief cause of national insecurity." - Celine's First Law
    37. Re:The problem is... by shutdown+-p+now · · Score: 1

      No one who wasn't literally insane would try to use smallpox as a weapon

      There's no shortage of people who are literally insane in politics. Consider what happens if the "Caliphate" gets their hands on some samples.

    38. Re:The problem is... by Anonymous Coward · · Score: 0

      AHEM...`SyFy'

      And I really wish it wasn't.

    39. Re:The problem is... by Anonymous Coward · · Score: 1

      No one who wasn't literally insane would try to use smallpox as a weapon

      Sanity is not all that it is cracked up to be. Perfectly seemingly sane people in places of high authority can be more wacked out than anyone you might meet down on 4th avenue in the middle of a sub-0 degree winter's night eating dog food from a rusty can.

      Human experimentation with these biological and chemical agents is most likely being conducted somewhere on the planet, but you will never hear about it on the nightly news until they want you to..

    40. Re:The problem is... by dgatwood · · Score: 1

      The SyFy version involves a pro wrestler playing the technician. Oh, and the plucky daughter just found out she's pregnant.

      --

      Check out my sci-fi/humor trilogy at PatriotsBooks.

    41. Re:The problem is... by dgatwood · · Score: 1

      What could possibly be gained from further experimentation at this point? We already know how to isolate it and how to produce vaccines for it. And for gene therapy, there are lots of other, less dangerous viruses that can be used as vectors for delivering genetic material. It seems that keeping anything more than the bare minimum amount of material needed to produce vaccines would fall pretty far towards the risk end of the risk-reward curve.

      --

      Check out my sci-fi/humor trilogy at PatriotsBooks.

    42. Re:The problem is... by fche · · Score: 1

      "What could possibly be gained from further experimentation at this point?"

      A rhetorical assertion of a negative is not very convincing.

    43. Re:The problem is... by bmo · · Score: 1

      There's no shortage of people who are literally insane in politics.

      Indeed. 1 out of 4 people has a diagnosable mental illness.

      An estimated 26.2 percent of Americans ages 18 and older â" about one in four adults â" suffer from a diagnosable mental disorder in a given year. When applied to the 2004 U.S. Census residential population estimate for ages 18 and older, this figure translates to 57.7 million people.

      --NIMH

      Consider what happens if the "Caliphate" gets their hands on some samples.

      You mean the theocrats that are always talking about bringing the US back to its "christian" roots?

      spit

      --
      BMO

    44. Re:The problem is... by shutdown+-p+now · · Score: 1

      You mean the theocrats that are always talking about bringing the US back to its "christian" roots?

      These guys don't need smallpox, because they're doing just fine with plain old JDAMs and Tomahawks.

      OTOH, when you're equally insane but don't have billions of dollars to piss off on making things go boom, you might start considering extreme but cheap options.

    45. Re: The problem is... by structural_biologist · · Score: 1

      But as it can be synthesised, that refutes the argument that "if we destroyed it, it would be gone forever"

      Yes. While destroying existing stocks would not eradicate the virus forever, it would still help minimize the risks of accidental releases.

    46. Re:The problem is... by dgatwood · · Score: 3, Informative

      In theory, you can always learn more by continuing to study something. In practice, though, modern medicine has a pretty complete knowledge of smallpox. Humans have been studying the disease since before anyone even knew what a virus was. There's evidence that the Chinese were inoculating people for smallpox over a thousand years ago. And the first practical, widespread form of that vaccine dates back to the late 1700s. This was literally the very first virus ever treated with a vaccine. It's well-trodden ground, research-wise.

      The problem is, this virus is highly contagious and relatively dangerous compared with other viruses. For variola major, the case fatality rate is typically 30–60%, which puts it among the worst communicable diseases out there, approaching the fatality rate of ebola, and far more contagious. With nearly a two-week average incubation period (and up to 17 days in the worst case), one minor screw-up could easily cause a very serious pandemic before enough vaccines could be produced and distributed.

      So basically, you have to weigh the odds of an accidental release (which, with recent revelations about this stuff getting lost for decades, then turning up by accident, seems not so improbable) against the relatively small chance of learning anything new from it that can't also be learned from cowpox or other similar viruses. On the risk-reward curve, this seems to be so far towards the "pure risk" end that any reward would border on undeniable proof of divine intervention, which means the speculated rewards would have to be pretty darn amazing for it to be worth the risk.

      --

      Check out my sci-fi/humor trilogy at PatriotsBooks.

    47. Re:The problem is... by Jane+Q.+Public · · Score: 1

      The point that I was trying to make is that comparing smallpox to a gun, or even a nuclear weapon, isn't accurate. Using smallpox as a weapon is MAD even if you're the only one using it.

      I understood your point. I was making a different one.

      Repeat: you don't want to be the only sane person in a room full of nutjobs with insane weapons. That would also be insane.

      Having live samples available is also not needed or useful for producing the vaccine.

      I disagree completely. You can't test immunity if you don't have something to be immune against. Generally speaking, dead-virus vaccines tend to be less effective than live-virus vaccines, and you can't create more dead virus unless you have live virus to make it from.

      Research doesn't take place in a vacuum. But before you jump on me, understand that I am fully aware that the "safe and secure" facilities used for this kind of research have had containment breaches in recent years.

      If you want a real example of insanity, read up on the containment breach a couple of years ago involving H5N1 flu virus that they were trying to make MORE virulent and contagious.

    48. Re:The problem is... by sFurbo · · Score: 1

      As an educated guess, the study into smallpox has been to figure out out why it is so contagious so that we can build our own great contagion.

      Or to figure out why it is so contagious, so we can better treat future diseases that uses the same methods. Without more information, it is hard to tell which end goal is more likely.

    49. Re:The problem is... by Anonymous Coward · · Score: 0

      So from the article.. http://crofsblogs.typepad.com/...

      While no humans fell ill as a result of the bird flu breach, CDC Director Dr Thomas Frieden has called it “the most distressing" in a series of safety breaches at the agency because of the public risk posed by the virus.
      Researchers at a high-security CDC influenza lab learned of their mistake in May. The contaminated bird flu samples had been sent to poultry researchers at the U.S. Department of Agriculture, who noticed their chickens all died.

      So it went from one high-contamination zone (or whatever those things are called) in research-center to another *lower-than-previous-lab*-contamination zone research-center where they noted a much higher fatality-rate in the chickens.. None of the potentially exposed workers and that is basically anyone that where in the room when they opened the vial, dressed in their lower-level safety gear or anyone that handled the chickens dressed in their lower-level safety-gear...

      I would still say that the labs are secure enough, but improvements are always welcome..

    50. Re:The problem is... by Solandri · · Score: 2

      Yes, the point is that it's like MAD and other weapons policies: you don't want to put down your gun (or shield, for that matter) while the other guy is still holding on to his.

      MAD doesn't work for self-replicating things like bioweapons. If you put your gun or nuke down, and the other guy still has his and decides to shoot at you, you're screwed.

      OTOH, if you destroy your smallpox virus samples, and the other guy still has his and decides to use it on you, well he's just given you a smallpox sample you can use right back on him just as if you'd never destroyed your samples.

      The only bioweapon for which MAD would work would be one which kills quickly enough that the target nation is killed off before it can collect samples and send them back to the attacker. But any bioweapon that kills that quickly would be useless because it would kill the victim before he could spread the contagion to others, thus defeating the very characteristic which makes a bioweapon a weapon of mass descruction.

    51. Re:The problem is... by Anonymous Coward · · Score: 0

      And the singular of bacteria is bacterium.

    52. Re:The problem is... by sFurbo · · Score: 1

      [...] the ideal virus to use as a biological weapon is a virus with long, mostly asymptomatic infectious phase and a high mortality rate.

      No, the ideal biological weapon does not spread from person to person. Any disease that does is guaranteed to infect your own population as well; it is basically a gun you can't aim, or a doomsday device (though not literally, it doesn't kill everybody).

    53. Re:The problem is... by MrL0G1C · · Score: 1

      You seem to have completely ignored the post you replied to, it's not like MAD because MAD stands for Mutually Assured Destruction. Smallpox is not MAD it is MAILS (Mutually Assured Itchy Little Spots) and as such is a stupid crap weapon. Smallpox inoculation was used by the Chinese over 400 years ago.

      As the parent mentioned, you don't need to keep stock because if your enemy has lost their marbles and launched itchy at you then you have a sample of it. And if you'd read the summary you'd know that you don't need live samples to research it and anyway, if someone made a weapon out of it they would have most likely mutated it in which case you wouldn't have a sample until they launched it at you.

      --
      Waterfox - a Firefox fork with legacy extension support, security updates and better privacy by default.
    54. Re:The problem is... by MrL0G1C · · Score: 1

      Smallpox is not a MAD weapon like nuclear weapons, that analogy does not work.

      Someone launches smallpox at you, what are you going to do, launch some kind of herpes at them?

      Also, US has thousands of nuclear weapons, so the MAD argument again doesn't work because the US have far superior weapon at their disposal.

      --
      Waterfox - a Firefox fork with legacy extension support, security updates and better privacy by default.
    55. Re:The problem is... by Anonymous Coward · · Score: 0

      The treatment for smallpox seems to be vaccination against it shortly after exposure; barring that it's mostly supportive and there's still a high (30%?) lethality, if I'm reading this right. Against someone that for whatever reason can't practically vaccinate a lot of people quickly (and would know to do so), that certainly sounds like it could cause some mass destruction.

    56. Re:The problem is... by Anonymous Coward · · Score: 0

      It's like HFT. The faster it goes, the more profitable it is. Now, we can make humans extinct in weeks. When we're down to nanoseconds, then we can feel completely secure.

    57. Re:The problem is... by Anonymous Coward · · Score: 0

      Nuked is nuked. It doesnt matter if the US is capable of blanket-nuking Russia 500 times, when blanket-nuking them once is enough.

      Lets look at another scenario. For a long time, Malaria was used as a cure for syphilis. This was due to the fact that syphilis was not able to withstand the temperatures that malaria brought the human body up to.
      They might find the same thing is possible for dealing with any of the anti-biotic resistant superbugs that are currently doing the rounds in hospitals, or any of the other weird and wonderful diseases that are cropping up due to our destruction of rainforests in order to make way for farmland.

    58. Re: The problem is... by Anonymous Coward · · Score: 0

      Since viruses mutate and make vaccines ineffective it's a good thing to keep several versions of a virus. Also vaccines cannot be stored indefinitely while viruses can be frozen and used to create more vaccine..

      It is never a good thing to destroy information.. Just limit what it can be used for, ie only allow it to be researched at a specific lab or keep it frozen, in a hermetically sealed container, until needed would also remove the risk of accidental releases.. If freezer fails then the container would prevent it from escaping.. And with sealed container i'm referring to a container that you would have to break to open.. (metal or glass container with the lid superglued/welded shut)

      It's better to keep a copy of it locked away in a safe place, unused for now, instead of just destroying it...

    59. Re:The problem is... by Anonymous Coward · · Score: 0

      Having several strains of a virus can actually be quite useful.. One example is how cowpox was used for the first smallpox vaccine...
      Having a strain of a virus that has a lower kill-ratio can even be used as a cheap vaccine....

      Example:
      - Weponized strain has a 90% deathrate
      - Non-weponized strain has a 10% deathrate
      And no time to syntesize a large enough volume of vaccine.. Just infect the population with the lesser evil and you reduce the deathrate from 9 in 10 to 1 in 10..

      Vaccines are very useful, but they are much more narrow than letting our own immune-system fight something on it's own..

      It's never good to destroy things that *might* help with something that could cause this much havoc.... As long as you see it as "destroyed" and put it in the "do not open until you are really screwed" locker..

    60. Re:The problem is... by operagost · · Score: 1

      No one who wasn't literally insane would try to use smallpox as a weapon

      Islamic extremists.

      --

      Gamingmuseum.com: Give your 3D accelerator a rest.
    61. Re:The problem is... by deadweight · · Score: 1

      Smallpox vaccine is over *200 year old* tech at this point. I think with over 2 centuries of data, we know it works and it is NOT made out of smallpox anyway. Want to DIY it? Go find a cow with cowpox and rub it until you get cowpox. You are now immune to smallpox!

    62. Re:The problem is... by gstoddart · · Score: 1

      If we voluntarily destroy all our samples, and some other nation doesn't, then there will be that much less smallpox. This is a valuable goal in itself, even if it doesn't mean that the virus has been completely eradicated.

      Except that governments have essentially stated that they're not willing to get rid of their stuff, in case someone else uses it.

      So, lots of research is conducted under the guise "well, we can find a cure in case someone else does it". The problem is, that same research can be used to make the weapons in the first place.

      You're saying the GPs argument doesn't make sense, but in fact governments have been using it for decades.

      It's real, and it's happening right now. If you don't think that's true, then you're somewhat out of touch.

      --
      Lost at C:>. Found at C.
    63. Re:The problem is... by gstoddart · · Score: 1

      Don't forget the goofy comic relief character. There's always one of those.

      Oh, and you need the military guy (or the guys in dark suits and sunglasses) in charge of making the weaponized version just in case, and who demonstrate that the good guys are sometimes crazy delusional bastards, and that morality is a grey area (especially when you think you're defending your country).

      There needs to be the greedy capitalist only interested in profit, even if that means some loss of life.

      You may also need a puppy to complete this trope. Or some other foil which has natural immunity that everybody needs to capture first.

      You might also need Steven Seagal just in case things get testy, but if he's the sherrif you're covered.

      --
      Lost at C:>. Found at C.
    64. Re: The problem is... by Redmancometh · · Score: 1

      The Russians actually attempted to we aponize the India-1 strain via refrigerated cluster bomb in the vector facility. They told us it was sewage treatment equipment when we inspected.

    65. Re:The problem is... by gstoddart · · Score: 1

      So the only thing destroying live smallpox samples does is reduce the chances of a catastrophic screw-up.

      You seem to underestimate the historical tendency of crazy tyrants to decide "if I can't win, everybody dies".

      WTF do you think "mutually assured destruction" was all about? The premise that nobody would actually be crazy enough to destroy the entire world.

      I think you attribute too much rationality to geopolitics. Now think of North Korea, and tell me just how much rationality you see.

      --
      Lost at C:>. Found at C.
    66. Re: The problem is... by Redmancometh · · Score: 1

      The vaccine is ineffective against the "cooked" strain which Russia tried to weaponize, and we keep at USAMRID. Look into the India-1 strain.

    67. Re: The problem is... by Redmancometh · · Score: 1

      The vaccine does not work against several variola strains.

    68. Re:The problem is... by Anonymous Coward · · Score: 0

      There are people that exist that believe an apocalypse needs to happen in order to bring the reincarnation of a deity back walking on earth, and that this is a desirable thing that is destined to happen. It's required for them to ascend to a supernatural state.

      These crazed cultists are called Christians.

      Not all of them believe that it's their duty to trigger a worldwide catastrophe, but a disturbing number do and you should be quite worried if you ever come to know how many of them are, and how many of them aspire to gain political power by running for office.

      I don't like people misrepresenting my religion. Apocalypse means "unveiling" or "making known" (in many Latin-based languages, the Revelation of St. John is known as the Apocalypse); it does not mean mass destruction. What is being revealed? Each human's true character. Many Christians believe the earth will be baptized by fire, but extremely few believe it is their duty to bring this about (hint: a larger percentage of Muslims are radical jihadists than percent of radical Christians who want to trigger the end of the world). Most Christians who believe in the end of the world are preppers, not instigators.

    69. Re:The problem is... by strikethree · · Score: 1

      No one who wasn't literally insane would try to use smallpox as a weapon

      Agree

      the infection would inevitably spread back to the country which initiated it

      That is a benefit. It can be spun as, "they are counterattacking", etc.

      and the idea that we would need samples of our own to retaliate is preposterous.

      Agree. We might want samples to create a cure... so samples of our own is still a good idea.

      The nightmare scenario is some Hitler-like dude inoculating his followers and letting lose the virus to destroy all of the impure people. As a state sanctioned weapon, biological warfare is virtually useless.

      --
      "Someone needs to talk to the tree of liberty about its ghoulish drinking problem." by ohnocitizen
    70. Re:The problem is... by Anonymous Coward · · Score: 0

      The virus can currently be recreated WITHOUT live samples. The vaccine is created from cowpox rather than the deadly smallpox, cowpox is still readily available. There is literally zero value in having live small pox.

    71. Re: The problem is... by deadweight · · Score: 1

      The cowpox trick or any of the vaccines?

    72. Re:The problem is... by Jane+Q.+Public · · Score: 1

      Smallpox is not a MAD weapon like nuclear weapons, that analogy does not work.

      Someone launches smallpox at you, what are you going to do, launch some kind of herpes at them?

      No, that's not the point. Having a live virus for developing vaccines and antivirals are where the usefulness is.

      It is very much like the anti-missile component of MAD, which neither side wanted the other to have.

    73. Re:The problem is... by Anonymous Coward · · Score: 0

      No one who wasn't literally insane would try to use smallpox as a weapon, the infection would inevitably spread back to the country which initiated it ...

      I seriously doubt that ANY world leaders are sane at this point.

    74. Re: The problem is... by Redmancometh · · Score: 1

      The cowpox trick for sure, and possibly others.

      There was the case where some of the weaponized agent got out and infected some people who were vaccinated.

  4. We made everything else extinct by rossdee · · Score: 2

    We should give some lifeform a break

    1. Re:We made everything else extinct by Dins · · Score: 1

      Sure, but couldn't we stick with ones like cute puppies, fluffy kittens, or bald eagles if we're handing out breaks? I mean, if we HAVE to "accidentally" let a lifeform go extinct, smallpox has my vote!

    2. Re:We made everything else extinct by Anonymous Coward · · Score: 0

      Viruses aren't alive.

    3. Re:We made everything else extinct by Anonymous Coward · · Score: 0

      Neither are you

    4. Re:We made everything else extinct by Anonymous Coward · · Score: 0

      I would vote for keeping smallpox for the sake of research (obviously under high containment). I would much rather get rid of mosquitos, since they are such great disease carriers.

    5. Re:We made everything else extinct by Anonymous Coward · · Score: 0

      A bald eagle ate my friend's cute puppy, you insensitive clod!

      ( :-( I wish I was joking... )

  5. Better safe than sorry by Anonymous Coward · · Score: 0

    Destroying smallpox samples doesn't magically erase the disease from existence.

    1. Re:Better safe than sorry by MouseR · · Score: 2

      Plus, having some in stock allows the the create of a vaccine if by some chance it ever emerges again.

    2. Re:Better safe than sorry by Dins · · Score: 2

      If it emerges again, I imagine finding a sample of the virus won't exactly be a problem...

    3. Re:Better safe than sorry by mythosaz · · Score: 3, Insightful

      Destroying smallpox samples doesn't magically erase the disease from existence.

      Correct.

      In erases it from existence by non-magic, real, tangible methods (e.g. destroying every last living member of the species).

    4. Re:Better safe than sorry by geekoid · · Score: 1

      If it emerges again t won't be exactly the same. Best to be prepared ahead of time instead of spending months, or years after it emerges trying to figure it out.
      . Meaning we will \have learned more techniques to help us respond to different vectors, not that it will reemerge exactly like something we have in a lab.
      plus, there is still a lot to learn fro it that applies to may viruses.

      --
      The Kruger Dunning explains most post on /. http://en.wikipedia.org/wiki/Dunning%E2%80%93Kruger_effect
    5. Re:Better safe than sorry by Triklyn · · Score: 1

      we've thought extinct multiple species before... like macroscopic seeable species... and then been really surprised when a member or two of said species fell out of a bush in front of a cameraman... don't be naive.

    6. Re:Better safe than sorry by mythosaz · · Score: 1

      Sure, there's a long, long list of Lazarus species, once thought dead but found alive.
      http://en.wikipedia.org/wiki/L...

      And we might clone back an Ibex someday again...
      http://en.wikipedia.org/wiki/P...

      But the list of extinct species vastly outnumbers the Lazarus list, and includes plenty that we're directly responsible for with our own hands.

    7. Re:Better safe than sorry by Triklyn · · Score: 1

      yeah, we know, things die real good around us humans for some reason.

      the point was, we suck at knowing things, even when those things are big enough for us to see.

    8. Re:Better safe than sorry by Oligonicella · · Score: 1

      We've had an anthrax vaccines since the 1800's.

    9. Re:Better safe than sorry by amRadioHed · · Score: 1

      True, but macroscopic species can survive on their own. Viruses need to infect hosts to spread, and many viruses don't remain viable for long outside of a host. From what I can find, it seems like smallpox is such a virus.

      --
      We hope your rules and wisdom choke you / Now we are one in everlasting peace
    10. Re:Better safe than sorry by Anonymous Coward · · Score: 0

      I think s/he should have said "no new smallpox cases reported" to WHO != no smallpox cases in the wild. FWIW I witnessed a couple of random smallpox cases in the 90s, so I'd bet good money that even now it's not entirely extinct.

    11. Re:Better safe than sorry by Qzukk · · Score: 3, Insightful

      If it's not exactly the same then what we've got wouldn't be very useful.

      I'm with the "destroy it" crowd. If someone attacks us with smallpox, nuke the fuck out of them.

      --
      If I have been able to see further than others, it is because I bought a pair of binoculars.
    12. Re:Better safe than sorry by Anonymous Coward · · Score: 0

      Smallpox can't go off and live in some remote jungle where there are no people, it can only live inside people, and it's pretty noticeable to the person when they are full of smallpox.

    13. Re:Better safe than sorry by mythosaz · · Score: 1

      Well, go get your Nobel prize in epidemiology, since the world's last recorded case of smallpox was in 1978.

    14. Re:Better safe than sorry by Anonymous Coward · · Score: 0

      Multiple genome sequences of the virus are publically available. You can't put that information back into the magic lamp.

    15. Re:Better safe than sorry by Anonymous Coward · · Score: 0

      Destroying smallpox samples doesn't magically erase the disease from existence.

      Correct.

      In erases it from existence by non-magic, real, tangible methods (e.g. destroying every last living member of the species).

      Except that isn't what will happen. What will happen is the destruction of every last known living member of the species

    16. Re: Better safe than sorry by MouseR · · Score: 3, Funny

      And they keep coming out with new albums.

    17. Re:Better safe than sorry by khallow · · Score: 1

      You seem awful confident about that assertion for some reason.

    18. Re:Better safe than sorry by TapeCutter · · Score: 1

      we suck at knowing things, even when those things are big enough for us to see

      Welcome to the real world where imperfect knowledge has been enshrined in a very useful philosophy we call "Science".

      Science is just highly refined common sense. The fact that the biblical plague of smallpox has not been seen in the wild for decades convincingly demonstrates science knows enough to control it, what more do you need to know? Sure it may pop up somewhere after all these years, but even if that very unlikely* event was to occur we have already demonstrated we know how to deal with it and stop it spreading. So even though we can never know for sure that every last smallpox bug has been killed, we do know that as long as our current knowledge is passed on to the next generation, smallpox will never again cause human miseries of biblical proportions. This scant knowledge also tells us that smallpox (alone) would be a stupid choice for a biological weapon.

      very unlikely* - Without special care smallpox does not survive for very long outside of a human host, the human body is it's unique natural habitat.

      --
      And did you exchange a walk on part in the war for a lead role in a cage? - Pink Floyd.
    19. Re:Better safe than sorry by Triklyn · · Score: 1

      :) found some preserved in scabs stuck in the pages of an old book.

    20. Re:Better safe than sorry by Triklyn · · Score: 1

      :) the eradication of smallpox is perhaps the shining pinnacle of human achievement... and cooperation.

      smallpox is easy to identify, much easier to control than polio. but that doesn't mean it's easy or uncostly. It took a full on decade with everybody involved, literally everybody. In the midst of the cold war.

      Again, we're discovering species every day, and sometimes we've mislabelled species extinct. And apparently we know less about the ocean depths than the moon's surface... so you know, yes we suck at knowing stuff :)

      like 95% of the universe.

  6. Mr. Self Destruct by Anonymous Coward · · Score: 0

    Got to keep our options open for ending the world.

    1. Re:Mr. Self Destruct by Anonymous Coward · · Score: 0

      I wanna fuck everyone in the world
      I wanna do something
      that matters

  7. Read The Demon in the Freezer by Gothmolly · · Score: 2

    Short answer, smallpox control has never really been that good. Also an answer - each government wants to keep the only supply as a potential weapon.

    --
    I want to delete my account but Slashdot doesn't allow it.
    1. Re:Read The Demon in the Freezer by geekoid · · Score: 2

      Potential defenses. It would be a stupid, horrible, and backfire in a lot of ways for a government to use it as a weapon. SOmething government have known since WWI
      Globally based theologically motivate nut jobs on the other hand, they won't care cause..'god'.

      --
      The Kruger Dunning explains most post on /. http://en.wikipedia.org/wiki/Dunning%E2%80%93Kruger_effect
  8. What a stupid question by Man+On+Pink+Corner · · Score: 5, Interesting

    "Why are scientists continuing to take chances with uranium?"
    "Why are scientists continuing to take chances with high voltage?"
    "Why are scientists continuing to take chances with dimethyl mercury?"

    Because science.

    Also, there's no reason to obsess over the presence of a few virus particles in a jar on a shelf somewhere, if we have the source code in the form of its gene sequence. In that case we'll be able to resynthesize the virus at our leisure, at some point in the not-too-distant future.

    And if we don't already have the gene sequence in hand, well, that's a problem in itself.

    1. Re:What a stupid question by geekoid · · Score: 1

      Well, we wold need the virus for experimentation.
      Of course if we can do it at leisure, then so can everyone else.

      --
      The Kruger Dunning explains most post on /. http://en.wikipedia.org/wiki/Dunning%E2%80%93Kruger_effect
    2. Re:What a stupid question by Triklyn · · Score: 2

      i'd say yes, but i'd hesitate still.

      epigenetic mechanisms are still being explored, and non-nucleotide based heredity like matrilineal passing of mitochondria. Remaking a virus from it's sequence seems like it should be really easy, and if there's any organism/automata that will be made first, it'll be a virus... but even still, there might be some transient quality that is... stored in ram and not in persistent memory that once lost is truly lost.

    3. Re:What a stupid question by mrchaotica · · Score: 3, Funny

      And if we don't already have the gene sequence in hand, well, that's a problem in itself.

      What do you think the odds are that you could download the smallpox genome off The Pirate Bay or some TOR site?

      --

      "[Regarding the 'cloud,'] ownership was what made America different than Russia." -- Woz

    4. Re:What a stupid question by Anonymous Coward · · Score: 0

      I can't believe that in 2014 scientists are still continuing to take chances with Dihydrogen Monoxide (DHMO) as well !!!

    5. Re:What a stupid question by Anonymous Coward · · Score: 0

      You can make the torrent if you like. Here is the sequence (all 185,000 nucleotides of it): http://www.ncbi.nlm.nih.gov/genome/?term=variola

    6. Re:What a stupid question by Anonymous Coward · · Score: 0

      Why didn't my anti-virus software stop me from accessing that?

    7. Re:What a stupid question by phantomfive · · Score: 1

      A more interesting question is, what are these scientists studying about the virus, and what are they learning?

      --
      "First they came for the slanderers and i said nothing."
  9. Benefits by Anonymous Coward · · Score: 2, Insightful

    They take chances with it because the benefits outweighs the risks.
    How about we focus on those things that actually gets people hurt, like banksters taking chances with the economy and politicians using the army to play chicken-race. You know, the stuff that actually gets innocent people killed.

    In the case of smallpox what would happen is that the scientist screwing up might get infected and placed in quarantine. Even in the case of an actual smallpox outbreak it can be contained again with proper vaccination.

    1. Re:Benefits by Oligonicella · · Score: 2

      "They take chances with it because the benefits outweighs the risks." A supposition on your part. No more, no less.

    2. Re:Benefits by operagost · · Score: 1

      How about we focus on those things that actually gets people hurt, like banksters taking chances with the economy and politicians using the army to play chicken-race.

      Both a red herring AND a false dichotomy. Impressive!

      In the case of smallpox what would happen is that the scientist screwing up might get infected and placed in quarantine.

      What if he's immune, and, becoming a carrier, boards a plane?

      --

      Gamingmuseum.com: Give your 3D accelerator a rest.
  10. Game theory by Falos · · Score: 2

    It's an inferior move to reduce your options and throw away something irreversibly. You don't delete documents when you have abundant storage, you don't discard items in a video game with endless inventory.

    I'll accept that having poorly tracked, poorly secured, poorly vetted, poorly restricted, and/or poorly located samples keeps them from being a benign non-factor as above.

    I don't accept that throwing them away (the ones we know about) is the only counter. Hell, we can spare a few grams of payload and put one in space.

    1. Re:Game theory by kbeech · · Score: 2

      Have Buckaroo Bonzai drop it off in the Eighth Dimension to keep Doctor Lizardo busy!

    2. Re:Game theory by jeffmeden · · Score: 1

      I don't accept that throwing them away (the ones we know about) is the only counter. Hell, we can spare a few grams of payload and put one in space.

      And wind up with *super*smallpox? Good fucking plan, Einstein!

      Actually, good fucking plan. Let's do it.

  11. Um... by Anonymous Coward · · Score: 1

    Those "recent blunders" were cases in which they thought they had destroyed samples, but they had not.

    If they'd decided to destroy "all" samples in 1986, those samples would not have been destroyed, because nobody knew they existed.

    Furthermore, there are smallpox victims buried in permafrost. Not to mention the published genome sequence.

    Permanently eliminating all smallpox samples isn't even possible. If you're going to decide whether to destroy a particular sample, you have to keep that in mind. Personally I tend to suspect you're better off to keep some around, in a place where you can find it, in case some of the stuff that you don't know about gets loose and starts causing disease.

  12. Why? by Anonymous Coward · · Score: 0

    Because its the perfect mass killer untraceable to the bastards that spread it. It fits perfectly into the model of all but 500,000,000 dead according to the Georgia guidestones..

  13. Beyond human efforts. by Doubting+Sapien · · Score: 4, Interesting

    Laboratory samples are not necessarily the only sources of still viable small pox virus. With climate change now a global reality, thawing of the arctic permafrost means that the remains of victims who died of smallpox before eradication, even if buried (but especially if not), can potentially still release the disease into the current population. There was some news a while ago when the the Spanish Flu of 1918 was recovered in this way, albeit intentionally in the interest of science. But who knows if/when nature should take it's course this way with small pox, without our help?

    --
    ========== "Hello World" in my programming language of choice: ATG - LET THERE BE LIFE - TAG ==========
    1. Re:Beyond human efforts. by gunner_von_diamond · · Score: 1

      There was some news a while ago when the the Spanish Flu of 1918 was recovered in this way, albeit intentionally in the interest of science.

      Source for this story?

    2. Re:Beyond human efforts. by Anonymous Coward · · Score: 5, Informative

      http://www.sciencedaily.com/releases/2007/07/070702145610.htm

      "In a mass grave in a remote Inuit village near the town of Brevig Mission, a large Inuit woman lay buried under more than six feet of ice and dirt for more than 75 years. The permafrost plus the woman's ample fat stores kept the virus in her lungs so well preserved that when a team of scientists exhumed her body in the late 1990s, they could recover enough viral RNA to sequence the 1918 strain in its entirety. This remarkable good fortune enabled these scientists to open a window onto a past pandemic--and perhaps gain a foothold for preventing a future one."

    3. Re:Beyond human efforts. by misterplow · · Score: 1

      Episode 18?

      http://en.wikipedia.org/wiki/The_Event#Episodes

  14. Not like it doesn't exist in more dangerous places by Anonymous Coward · · Score: 1

    If forgotten, still infectious smallpox scabs are floating around, why does it matter if a couple of extremely secure and capable labs have a sample?

    We don't *think* we need the samples for anything, but next week someone could invent a new form of analysis that obtains invaluable new data from live virus samples.

  15. It's coming by zeroryoko1974 · · Score: 1

    Captain Trips is only a matter of time. Or zombies.

  16. problem? by Charliemopps · · Score: 1

    How problematic is a 60yr old vial of likely dead virus anyway?

    According to the agency, the virus was freeze dried and sealed in melted glass and the samples have been in storage since the 1950s.

    And they were sealed in melted glass? Come on...
    Sounds like a BS "Panic! Your life is in danger!" story to distract us from the worlds real problems.

  17. It's a great weapon. by Lumpy · · Score: 1

    Honestly, what a fantastic way of completely screwing your enemy. smallpox bombs are a fantastic weapon that will make the people turn on their local government and military as soon as their children start dying.

    Biological and Chemical warfare is worse than nuclear warfare, and it's heinous to it's core.

    --
    Do not look at laser with remaining good eye.
    1. Re:It's a great weapon. by Anonymous Coward · · Score: 0

      that will make the people turn on their local government and military as soon as their children start dying.

      This has been proven wrong time and time again: Bombing a people makes them increase their support for their government and the fight against whomever is bombing them.

    2. Re:It's a great weapon. by geekoid · · Score: 1

      Let us know when you have a virus that obeys border laws.

      --
      The Kruger Dunning explains most post on /. http://en.wikipedia.org/wiki/Dunning%E2%80%93Kruger_effect
    3. Re:It's a great weapon. by Triklyn · · Score: 1

      all, just shoot any potential carriers.

    4. Re:It's a great weapon. by Anonymous Coward · · Score: 0

      It's really easy. all your soldier have a shoot to kill order for anyone, tell them they are infected and are coming to infect you, even timid soldiers will mow down a crying 6 year old.

    5. Re:It's a great weapon. by SumDog · · Score: 1

      He was being sarcastic

    6. Re:It's a great weapon. by SumDog · · Score: 1

      Conventional weapons also don't know when treaties have been signed: land mines, cluster bombs...

  18. (thwarted by Western scientists) by Threni · · Score: 1

    There's another kind of scientist?

  19. At least RTFS by Anonymous Coward · · Score: 0

    "...changes in research methods, which no longer require the use of live viruses, mean that stocks of the live smallpox virus can and should finally be destroyed."

  20. Because... by Anonymous Coward · · Score: 0

    The NWO is planning to release a deadly virus that will impact all the world, that is why there has been so much talk recently about various outbreaks.

    A virus will likely be released by mr. Obama's people, someplace in the far east, or the Middle East.

  21. Smallpox: The Movie by DarthVain · · Score: 1

    Sounds like a script from a movie...

    Earth 2110 A mutated smallpox pandemic is sweeping the world.
    Researchers desperately need an original sample from which to make an vaccine.
    Man foolishly destroyed all samples back in the dark years of 2014.
    Now a ragtag group of adventurers attempt to find the last remaining sample, the world depends on it!

    1. Re:Smallpox: The Movie by Anonymous Coward · · Score: 0

      The last report of a live sample is found in Shangri-La and requires the befriending of a skittish unicorn... And no doubt the movie will also have a snotty teenager that learns to appreciate her/his parent throughout the course of the movie.

    2. Re:Smallpox: The Movie by Anonymous Coward · · Score: 0

      Hey, I'm already writing this script. Stop it.

  22. serious ?: by Anonymous Coward · · Score: 1

    if we have the sequence(s) & it can be replicated can it ever actually be considered eradicated?

    [edit: ironically enough my captcha word was "pathogen" :D ]

    1. Re:serious ?: by Triklyn · · Score: 1

      again, something might be lost in the reproduction. we don't know enough about the transient interactions to know if anything important is.

  23. I'd keep it on file by Karmashock · · Score: 2

    I'd avoid weaponizing it. I think the science labs that weaponize viruses on the argument that they need to know how to counter weaponized viruses is a little bunk. But I do think the viruses should be kept on file. Keep them in deep dark vaults... but keep them. I don't know if we'll ever need them for some reason but if we do they're there.

    As to the worry that scientists might misuse them. I didn't say I'd let the scientists play with them. Just keep them. Seal them away somewhere and require a public hearing to release them to any lab.

    Possibly include a 24 hour armed guard to accompany the virus if its released to a lab. The expense of such a guard should discourage casual research.

    --
    I've decided to stop wasting my time responding to AC trolls/sockpuppets... so if you want a response from me... login.
    1. Re:I'd keep it on file by Anonymous Coward · · Score: 0

      Hell, only allow research by people not wearing biohazard-suits and do not let them out of the lab if infected... THAT would really discourage casual research :)

  24. Too hi by Impy+the+Impiuos+Imp · · Score: 1

    Why Are the World's Scientists Continuing To Take Chances With Smallpox?

    In the rare case of necessary future research, it will allow them recognition in their field, leading to alpha status and thus more pussy.

    Oh, you meant an analysis lower down within the memetic virtual worldview. Hmmmm. Why does a dog bark at strangers?

    --
    (-1: Post disagrees with my already-settled worldview) is not a valid mod option.
  25. theory != practice by dltaylor · · Score: 1

    "In theory, theory and practice are the same. In practice, they are not."

    If you want to know that you can protect against/treat smallpox virus, even if mutated (un)naturally, you have to have some with which to work.

    The question is fundamentally nonsense.

  26. Re:The solution is... by Anonymous Coward · · Score: 0

    Our best defense against the future more serious threat (Big Pox) is to fully understand what we can study now (Small Pox).

    If we get rid of this one, what will you fear next? weaponized toenail fungus?

  27. If (insert item here) is outlawed . . . by DutchUncle · · Score: 1

    . . . . then only outlaws will have (repeat item here).

  28. What about alien attacks? by clovis · · Score: 1

    What if it turns out that the disease that killed all the Martians when they attacked back in 1938 was smallpox, and what if that was the ONLY disease they were susceptible to?
    Wouldn't we feel like dummies if we destroyed all our
    supplies and they attacked again?

  29. once again, White Christans fuck over everybody! by Thud457 · · Score: 0

    ain't gonna fall for that blanket trick a second time, white devil!

    --

    the preceding comment is my own and in no way reflects the opinion of the Joint Chiefs of Staff

  30. FYI, smallpox is not needed to make vaccine by clovis · · Score: 1

    For those who don't already know, the smallpox vaccine is the not made from smallpox.
    It was originally made from a virus commonly known as "cowpox", although they may have used the horse version for development.

    smallpox virus is "variola"
    the vaccinating (cowpox) virus is "vaccinia"

    The point is, we don't need smallpox to make more vaccine and would not do that anyway.

    The CDC has enough vaccine to vaccinate everyone in the USA for smallpox, should it come to that.

    1. Re:FYI, smallpox is not needed to make vaccine by Grog6 · · Score: 1

      As I mentioned above, almost everyone over 50 in the US was vaccinated in the 60's.

      We lined up in school, lol.

      I still have my scar. :)

      --
      Truth isn't Truth - Guliani
    2. Re:FYI, smallpox is not needed to make vaccine by Anonymous Coward · · Score: 0

      As I mentioned above, almost everyone over 50 in the US was vaccinated in the 60's.

      We lined up in school, lol.

      I still have my scar. :)

      Me too.
      I have to wonder if the person hoarding the smallpox is thinking "if this present generation gets any more annoying ..."
      Hey kids, playing with dubstep is playing with fire.

    3. Re:FYI, smallpox is not needed to make vaccine by Anonymous Coward · · Score: 0

      As I mentioned above, almost everyone over 50 in the US was vaccinated in the 60's.

      We lined up in school, lol.

      I still have my scar. :)

      Perfect. That will make it all the easier to round you all up for erradication. Just kidding... old people are great!

  31. ahhh Hans, wry are arways you bleaking my barrs??! by Thud457 · · Score: 1

    I just verified that Thinkgeek doesn't have smallpox

    ahhh, nostalgia!

    --

    the preceding comment is my own and in no way reflects the opinion of the Joint Chiefs of Staff

  32. Re:once again, White Christans fuck over everybody by RoknrolZombie · · Score: 2

    Of course not. It'll be bundled with a "free" cell phone for underdeveloped nations...or for populated nations. It'll be produced by the US and built in China, and nobody will have any idea where along the chain they got infected...

  33. Re:once again, White Christans fuck over everybody by Oligonicella · · Score: 1

    One English military officer suggested it - Lord Jeffrey Amherst. It's unknown if he actually attempted it. That's the entirety of the story. Weak attempt at religion bashing.

  34. To Paraphrase Optimus Prime... by Anonymous Coward · · Score: 0

    "What if we destroy the last samples, and you turn out to be wrong that it's extinct?"

  35. Re: Same reason we keep developing nuclear weapon by SvnLyrBrto · · Score: 3, Funny

    Why⦠what a fascinating idea. To hold in my hand that capsule⦠to know that life and death on such a level was my choice. Such power would set me up above the gods!

    --
    Imagine all the people...
  36. Bad Idea by Anonymous Coward · · Score: 0

    Who knows when the smallpox virus might be part of the solution to an even bigger medical (or other) problem? For example, researches are looking into the use of HIV in fighting cancer.

    Smallpox is one of the most studied viruses ever. Something about it could be made to serve a useful purpose. The possibility is remote, but we shouldn't close it entirely.

  37. Aliens by SumDog · · Score: 1

    This just makes me think of the Alien's movie, where The Company(tm) wants to harvest, study and learn from the Xenomorphs, even after being fully aware at how horribly dangerous they were.

  38. Cowpox is where "vaccine" comes from. by billstewart · · Score: 1

    No, we wouldn't need our own live smallpox to construct a vaccine against a weaponized smallpox. The original vaccine was made from cowpox, and eventually the closely related vaccinia disease, and was much safer than smallpox-based inoculation which was the other prevention available at the time.

    The only reason to keep the stuff around is to attack the Russians in case they attack us with their smallpox, and we can be better people than that. Time to destroy it, and convince Putin to destroy his stockpiles also.

    --

    Bill Stewart
    New Fast-Compression-only CPR http://preview.tinyurl.com/dy575ks
    1. Re:Cowpox is where "vaccine" comes from. by Anonymous Coward · · Score: 0

      Time to destroy it, and convince Putin to destroy his stockpiles also.

      Putin does what he likes. Good luck convincing him about anything.

    2. Re: Cowpox is where "vaccine" comes from. by Anonymous Coward · · Score: 0

      D L Henderson (one of the original eradicators) said the India one strain was hindered by the vaccine in the same way a bullet was by toilet paper...its the one we have at USAMRID and the russians have at Vektor

    3. Re: Cowpox is where "vaccine" comes from. by jbolden · · Score: 1

      Then we need a better vaccine.

  39. we know the smallpox genome by Anonymous Coward · · Score: 0

    and can obtain it from commercial DNA fabrication services if needed. No reason to keep the live virus, when we've got the data in sillico.

    1. Re:we know the smallpox genome by Anonymous Coward · · Score: 0

      How long does it take to fabricate? How many potential death's could have been prevented *if* there would be a new outbreak that requires live samples?

  40. sounds illegal by Anonymous Coward · · Score: 0

    Don't we have an endangered species act?

  41. we can stop diseases quickly by Anonymous Coward · · Score: 0

    As long as a disease is limited to a smallish area, it is trivial to wipe out.

    Consider polio. It is found in northwestern Pakistan. It might be found in northern Nigeria and/or northern Afghanistan. Want it gone? We can get the job done in less than a half hour. Yeah, it involves nukes, but the long-term death count would be greatly reduced.

    It's like getting people to stop fighting over Jeruselam. We can do it.

  42. Chances or Risks? by Anonymous Coward · · Score: 0

    Chances or Risks?

  43. Re:ahhh Hans, wry are arways you bleaking my barrs by Anonymous Coward · · Score: 0

    I just verified that Thinkgeek doesn't have smallpox

    They destroyed all copies. But there might be some survivors hiding in a closet.

  44. Re: Same reason we keep developing nuclear weapon by Anonymous Coward · · Score: 0

    But life finds a way. Even though virus' aren't alive, you get the point

  45. Ice-9 by Squidlips · · Score: 1

    All the tin-pot dictators wanted it...

  46. Why are Librarians taking chances with Mein Kampf? by Martin+S. · · Score: 1

    It is stupid to think destroying lab stocks removes the 'problem'.

    The 'problem' is not these stocks but undiscovered natural reservoirs of diseases.

    Destroying the stock reduces capability of the biomedical community to respond to fresh out breaks.

  47. Destroying it all is a bad idea by whitroth · · Score: 1

    Is making any species extinct a good idea? If so, why?

    I mean, if it had been destroyed in '86, we'd never have sequenced it. What more info can we get from it 10 or 20 years from now?

    Also, this whole "debacle" is massively overblown. Note that a) the amules were all still securely sealed, and in appropriate storage... it's just that they should have been known, and put in recorded storage.

    For that matter, where's whatever you were looking for at home? Or when was the last time your boss asked you to find something that you spend hours, or weeks, on and off, looking for? Now let's talk about the NIH campus in Bethesda, with (depending on your sources) somewhere betwwn 18,000 and 35,000 people who work there every day, and sixty or eighty buildings, including a large hospital. That is *not* a small place to misplace something.

    Oh, and I've yet to see or hear *anything* as to *why* it was left there. Was the team that was working on it laid off, or reorganized somewhere else?

    No, destroying it all's a bad idea.

                mark