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Device Allows Paralyzed Rats To Walk, Human Trials Scheduled Next Summer

An anonymous reader writes "A new technique pioneered by scientists working on project NEUWalk at the Swiss Federal Institute for Technology (EPFL) have figured out a way to reactivate the severed spinal cords of fully paralyzed rats, allowing them to walk again via remote control. Human trials are scheduled for next summer. "We have complete control of the rat's hind legs," EPFL neuroscientist Grégoire Courtine said. "The rat has no voluntary control of its limbs, but the severed spinal cord can be reactivated and stimulated to perform natural walking. We can control in real-time how the rat moves forward and how high it lifts its legs."

52 of 85 comments (clear)

  1. QWOP IRL by Anonymous Coward · · Score: 1

    Bad joke, given that this might one day truly help people. But it was the first thing that came to mind.

  2. Re:How much longer by tloh · · Score: 1

    Too late.
    Death eaters already routinely cast the Imperius Curse on unsuspecting muggles world leaders to further their agenda for an anti-Christian world empire.

    --
    Stay sentient. Don't drink bad milk.
  3. humans walk like rats? by Noah+Haders · · Score: 4, Funny

    I don't see how this can be practical to have a device so humans can walk like rats.

    1. Re:humans walk like rats? by MrKaos · · Score: 1

      I don't see how this can be practical to have a device so humans can walk like rats.

      Yeah but it would be cool if it could help you rat dance!

      --
      My ism, it's full of beliefs.
    2. Re:humans walk like rats? by camperdave · · Score: 4, Funny

      I don't see how this can be practical to have a device so humans can walk like rats.

      To be fair, they're starting with lawyers first.

      --
      When our name is on the back of your car, we're behind you all the way!
    3. Re:humans walk like rats? by ATMAvatar · · Score: 1

      Why take a step backwards and test lawyers? Aren't the rats closer to being human?

      --
      "They that can give up essential liberty to obtain a little temporary safety deserve neither liberty nor safety."
    4. Re:humans walk like rats? by wonkey_monkey · · Score: 1

      Why take a step backwards

      If that happens, just put the batteries in the other way round.

      --
      systemd is Roko's Basilisk.
    5. Re:humans walk like rats? by expatriot · · Score: 1

      There are some things rats will not do.

    6. Re:humans walk like rats? by Noah+Haders · · Score: 1

      Dude have a laugh. Life's too short.

    7. Re:humans walk like rats? by antdude · · Score: 1

      I thought lawyers were sharks. :P

      --
      Ant(Dude) @ Quality Foraged Links (AQFL.net) & The Ant Farm (antfarm.ma.cx / antfarm.home.dhs.org).
  4. the next logical step by Doubting+Sapien · · Score: 3, Insightful

    After they optimize this for human physiology and gain commercial approval, this technology will obviously be a boon for accident victims. However, the engineer in me can't help but think of how far they can take the cyborg theme. ALS is a disease where motor neurons selectively waste away. Do we dare hope that we can eventually bypass the whole path of neuro connections to directly stimulate individual muscle groups?

    --
    ========== "Hello World" in my programming language of choice: ATG - LET THERE BE LIFE - TAG ==========
    1. Re:the next logical step by Electricity+Likes+Me · · Score: 2

      Actually what I'm wondering here is if they can control how the rat walks, then what's stopping them from using electrical receptors on the other side of the break to let the rat control how it's legs moves? If the technology is precise enough to stimulate, then it can surely be precise enough to receive.

    2. Re:the next logical step by pitchpipe · · Score: 2

      However, the engineer in me can't help but think of how far they can take the cyborg theme.

      Are you kidding me? Imagine having one that you could just strap on for an hour, get on a treadmill, and then read a book or surf the net while your legs did their thing. I'd exercise everyday.

      Sign me up!

      --
      Look where all this talking got us, baby.
    3. Re:the next logical step by Anonymous Coward · · Score: 2, Insightful

      The engineer in me says that this is going to be a LOT more difficult in humans than in rats. In the demo video the rat is actually suspended, which means the legs are not actually supporting the weight of the body, which means the feet, ankles, toes, knees, are not making minute changes to carry and balance the load of the body. The lack of feedback from the nerves and the inner ear, means they would need multiple sensors for balance, and need to be able to control many muscle groups very precisely. Knowing this, I don't see how this could work very well. I can see only one good use which would be in a therapeutic swimming pool and using this to prevent the atrophy of the legs which leads to all kinds of health complications.

    4. Re:the next logical step by Doubting+Sapien · · Score: 1

      I don't have very deep background in this area, but a bit of trivia from a neuroscience class two years ago is relevant here. Decades ago, before research ethics developed to its current state, there was an experiment using a de-brained but still living cat that showed the neural circuitry in the spinal cord was sophisticated enough to coordinate walking/running with no input/output to the brain. The following youtube clip shows film footage of the cat suspended over a treadmill where the motion of the tread stimulated anatomically correct gaits of normal healthy animals. https://www.youtube.com/watch?... In other words, the artificial stimulation doesn't really control *how* they walk or perform other tasks that are "instinctual". Most of that is an innate ability of the central nervous system. Voluntary control of muscles and movement, especially fine control, like dodging obstacles, for example, are still a bit tricky to hack at the current state of understanding.

      --
      ========== "Hello World" in my programming language of choice: ATG - LET THERE BE LIFE - TAG ==========
    5. Re:the next logical step by Electricity+Likes+Me · · Score: 1

      Right, this much I kind of inferred - but what I'm wondering is, surely you could connect a reasonably blunt reading of spinal cord electrical signals to electrodes, and use that to control the stimulation of the walking action. The brain's body map is a pretty fluid vehicle, so even with limited control it seems likely that people would be able to control the synthetic system fairly well.

    6. Re:the next logical step by Sarius64 · · Score: 1

      That was my first thought. I remember seeing some spa equipment that worked adults' bodies as they read books and "relaxed". Imagine if you could walk 20 miles a day without cognitive input required.

    7. Re:the next logical step by d'baba · · Score: 1

      ...there was an experiment using a de-brained but still living cat that showed ...

      How pithy.

    8. Re:the next logical step by amalcolm · · Score: 1

      Goodgod man! (or woman) What's wrong with you!!

      --
      Time for bed, said Zebedee - boing
    9. Re:the next logical step by geekoid · · Score: 1

      So you want one of these:
      https://www.youtube.com/watch?...

      --
      The Kruger Dunning explains most post on /. http://en.wikipedia.org/wiki/Dunning%E2%80%93Kruger_effect
    10. Re:the next logical step by Carewolf · · Score: 1

      However, the engineer in me can't help but think of how far they can take the cyborg theme.

      Are you kidding me? Imagine having one that you could just strap on for an hour, get on a treadmill, and then read a book or surf the net while your legs did their thing. I'd exercise everyday.

      Sign me up!

      What would the difference be? Unless you detach your upper body, it is still going to follow the legs and bump und down as much if not more that if you ran normally. Reading a book is not going to get any easier, the main problem is all the bouncing, so I recommend audiobooks.

  5. Meanwhile... by ArsonSmith · · Score: 1

    Meanwhile many non-walking humans are sitting around waiting for the trials.

    --
    Paying taxes to buy civilization is like paying a hooker to buy love.
  6. Re:Poor rats by blue+trane · · Score: 1, Troll

    Yes, what kind of monsters sever the spinal cords of fellow mortals, in cold blood. They should be prosecuted for assault.

  7. Have at it by Tablizer · · Score: 1

    There are about a dozen politician jokes to be mined from this story.

  8. late to the party by tloh · · Score: 4, Informative

    Slashdot is a bit slow on this one. Here is a TED talk from the researcher posted last year.

    https://www.ted.com/talks/greg...

    --
    Stay sentient. Don't drink bad milk.
  9. So it begins by Synon · · Score: 1

    I knew it was just a matter of time before the zombie apocalypse, but I never thought it would be done by remote control.

  10. Control how high it lifts its legs... by gshegosh · · Score: 1

    I predict a huge market that is not helping people walk.

  11. Jackass Moment by d'baba · · Score: 1

    The difference between this and what we did back in the 60's in biology class (making the frog's leg jump with a jolt of electricity) is sad, considering. The control systems are certainly better. Oh, and the marketing, yes.

    Wake me when they have a video of a human doing this.

    1. Re:Jackass Moment by m.alessandrini · · Score: 1

      Obviously the average slashdot reader can always do better, be it rocket science or neuro science. Ask a paralysed person it this is good news or only "marketing". And why test it, risk some human lifes from the very beginning.

    2. Re:Jackass Moment by geekoid · · Score: 1

      When you find yourself typing this:
      "Jackass Moment "
      Just cancel it and move on. Seriously, you recognized you were being a jackass but march onward.

      --
      The Kruger Dunning explains most post on /. http://en.wikipedia.org/wiki/Dunning%E2%80%93Kruger_effect
  12. Re:Poor rats by m.alessandrini · · Score: 4, Insightful
    Please everyone, let's draw a line with animal-right defense. It's rats here, the same rats we exterminate in thousands when they approach our towns. And we eat a lot of animals more intelligent than rats (we = majority of people). I would argue that curing lethal diseases and paralysis is as important as eating. Another thing I really hope for the future is having transpantable organs grown in pigs or other animals.

    I'd rather die than have dozens, hundreds or thousands of animals tortured to help me live more comfortably

    Really? Really? Tell us again when you'r really dying.

  13. Re:Poor rats by Puff_Of_Hot_Air · · Score: 1

    They severed the spinal cord of a rat?

    Why do you make this assumption? They may well be finding poor injured rats and repairing their spines to try and provide them with a better life. Would you prefer they simply leave these rats to undoubtedly die from their disability? And if it was some other "evil" scientist who did this to the rat, is it not good that this scientist came along to try and help the rat? Would you tar all scientists with the same brush? Clearly the scientist repairing the rats spine is a saint, and not the devil you make out! And if it was in fact the same scientist in both cases, should the scientist not try and help the rat that he (perhaps unwittingly) injured? Have you never done something that later you regret; lashed out and hurt someone you cared about? Would you judge this repentant man for attempting to right a previous wrong? Where you there? Did you feel his utter anguish at the wrong he committed? His exultant joy as the rat took it's first step from his painstaking work? No! You eat your vegetables and consider yourself superior! This man looked into the darkness of his soul and turned and made a difference! And yet you judge him! Where were you when the rats cried out for justice? Where were you when they laid out the baits?! Hypocrite! For shame I say, for shame!

  14. Re:Poor rats by K.+S.+Kyosuke · · Score: 3, Funny

    I go out of my way to find products that weren't tested on animals. And yes, I am a vegetarian.

    You only eat plants that haven't been tested on animals?

    --
    Ezekiel 23:20
  15. Accidental by ThatsNotPudding · · Score: 1

    "The rat has no voluntary control of its limbs, but the severed spinal cord can be reactivated and stimulated to perform natural walking. We can control in real-time how the rat moves forward and how high it lifts its legs."

    This also accidentally describes the nearly-attained goals of the US state security organs (with assists from the POTUS and the Supremes).

  16. What is more interesting by kilodelta · · Score: 1

    Are the groups researching repair of spinal cord injuries. Seems if you get to them before too much time passes you can get the nerves to re-grow and connect again with a certain compound. I think that will stave off future handicapped people.

  17. Re:How much longer by thieh · · Score: 1

    You are missing the point. This devices make great assassins for mafia or gangs once they hack the system because if you can show the system is hacked to get the guy off the hook, the thread of investigation is kind of broken there. And if you cannot, you got your scapegoat.

  18. Re:Poor rats by m.alessandrini · · Score: 1

    I realize my post sounded cynical, but research on animals (or part of it) can contribute to save your life or the life of a loved one, so you have to choose, and it's sad to say but humans have evolved more than other animals, and exploit this condition to try to fight diseases and other problems. Maybe who knows, one day we will be able to save all the other species in exchange, think for example if one day a big asteroid will be directed towards earth and we will be able to deflect it.

  19. Re:Poor rats by lexman098 · · Score: 1

    How we deal with infestations is a different issue. We can argue that separately if you want, but what I saw was an animal that in all probability was forcibly paralyzed and then made to undergo painful experiments. Just because it's not intelligent doesn't mean it can't feel pain, and we're not talking about saving people's lives here. My position is that they should be doing these experiments on willing and already paralyzed people that want to give back to the scientific community for the sake of future generations. And before you ask, yes I would participate.

  20. Re:Poor rats by hypergreatthing · · Score: 1

    Plants are alive too. Countless get murdered in (quite literally) hot steaming blood.
    Show me the humans that can photosynthesize.

  21. Understanding sacrifices by Jonifico · · Score: 2

    If you had a paralyzed family member like me, you'd really understand what this means to a lot of people. I'm thankful for those rats, I'm sorry they might've to suffer to get us here, but then again, it gives us hope. It might be too late for my aunt already, but if future generations of handicapped people can take advantage of this, that's amazing.

    1. Re:Understanding sacrifices by geekoid · · Score: 1

      "future generations of handicapped people "
      If this works, future generation of Handicapped people won't exist.

      The real tragedy is that wan't have anyone's parking space to steal.

      That was a joke. So calm the fuck down.

      --
      The Kruger Dunning explains most post on /. http://en.wikipedia.org/wiki/Dunning%E2%80%93Kruger_effect
  22. Norm MacDonald by XxtraLarGe · · Score: 1

    Any time I hear about spinal injuries in rats, it always reminds me of this (go to 3:56). "Well that's good news, huh? Getting all those rats up and around again!" :-D

    --
    Taking guns away from the 99% gives the 1% 100% of the power.
  23. Re:Poor rats by m.alessandrini · · Score: 1
    You're right, I too feel for animals suffering, but would we be here talking about this if medicine had not evolved like it currently has, thanks (also) to research on animals? It's a sad choice you must make. And maybe you would not find a high enough number of human patients to experiment with.

    A friend of mine working in a lab with rats, told me that rats live a very comfortable life there, at least until they are "used", arguably more comfortable than rats living in the wild. I know, this is not exactly a valid excuse.

  24. Re:Poor rats by Eevee · · Score: 1

    I go out of my way to find products that weren't tested on animals.

    Those products are still being tested on animals; it's just that the animal being used for testing is you.

  25. Re:Poor rats by canadiannomad · · Score: 1
    --
    Hmm, the humour and sarcasm seem to have been be lost on you.
  26. Re:Poor rats by K.+S.+Kyosuke · · Score: 1

    Plant photosynthesis is Precambrian bacterial slavery!

    --
    Ezekiel 23:20
  27. Food for thought for rat supporters... by jeffb+(2.718) · · Score: 1

    If this kind of rat experimentation bothers you, and I can't say that it shouldn't, I'd like to ask two follow-up questions.

    First, have you ever seen what a cat does when it encounters a rat or a mouse? Cats are predators, but they don't always just swiftly kill and eat their prey. They often toy with it for quite a long time.

    Second, having learned about this behavior, are you ready to call for the abolition of cats? I'll promise you that cats torture and kill far more rats worldwide than all scientists put together, and we gain far less from that activity than we do from medical research.

    If you oppose animal testing, I can see that as a principled and well-supported stand. But if you aren't willing to go further and call for the end of domestic cat propagation, I'd very much like some insight into your reasoning.

  28. Cymeks by johanw · · Score: 1

    Yes! The first step in developing Cymeks (look up the term if you're unfamiliar with the Dune universe).

  29. Re:Poor rats by geekoid · · Score: 1

    " Nothing anyone says will ever convince me t"
    so thinking is straight out with you then? Good to know, AC tough guy.

    --
    The Kruger Dunning explains most post on /. http://en.wikipedia.org/wiki/Dunning%E2%80%93Kruger_effect
  30. Re:Poor rats by geekoid · · Score: 1

    " and it's sad to say but humans have evolved more than other animals, "
    it's not sad as much as it is factual incorrect.

    Every species first order of business is survival of the species. We need animal testing for many things, I"m not arguing against it.

    --
    The Kruger Dunning explains most post on /. http://en.wikipedia.org/wiki/Dunning%E2%80%93Kruger_effect
  31. Re:Poor rats by m.alessandrini · · Score: 1

    What do you mean by "evolved"? I mean it in the technological sense, like going beyond what nature offers you to survive.

  32. Oh come on, remote-control walking and by PJ6 · · Score: 1

    no reference to the wrong trousers?