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Spread of Breast Cancer Linked To Compound In Asparagus and Other Foods (theguardian.com)

Asparagus and other foods like potatoes, nuts, legumes and soy contain a compound known as asparagine, which researchers believe helps drive the spread of breast cancer to other organs. "When scientists reduced asparagine in animals with breast cancer, they found that the number of secondary tumors in other tissues fell dramatically," The Guardian reports. "The spread of malignant cells, often to the bones, lungs and brain, is the main cause of death among patients who are diagnosed with breast cancer." From the report: Asparagine is an amino acid that is made naturally in the body as a building block for proteins. But it is also found in the diet, and in high levels in certain meats, vegetables and dairy products. The international team of cancer specialists from Britain, the U.S., and Canada studied mice with an aggressive form of breast cancer. The mice develop secondary tumors in a matter of weeks and tend to die from the disease within months. Writing in the journal Nature, the researchers describe how they reduced the ability of breast cancer to spread in the animals by blocking asparagine with a drug called L-asparaginase. To a lesser extent, by putting the animals on a low-asparagine diet worked too. Inspired by the results, the scientists examined records from human cancers and found that breast tumors that churned out the most asparagine were most likely to spread, leading patients to die sooner. The same was seen in cancers of the head, neck and kidney.

74 comments

  1. So... by Anonymous Coward · · Score: 0

    How safe is this L-asparaginase? A viable and simple way to slow cancer down, giving you more time to get better?

    1. Re:So... by Anonymous Coward · · Score: 0, Troll

      All drugs have side effects. Better to replace all natural breasts with large silicone bolt-ons, just to be safe.

    2. Re:So... by GrumpySteen · · Score: 5, Informative

      It was approved for use by the FDA in 1978 and is considered one of the safer chemotherapy drugs, so it is definitely a viable drug for cancer patients.

      The study isn't about discovering a new drug. It's is about gaining a better understanding what the existing drug does so that we can use it more effectively.

    3. Re:So... by hcs_$reboot · · Score: 4, Funny

      So... stop eating asparagus, potatoes, nuts, legumes. Focus on processed meat, butter and sweets to keep the cancer away.

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    4. Re:So... by Anonymous Coward · · Score: 0

      As long as kale is still safe to eat.

    5. Re:So... by Anonymous Coward · · Score: 0

      Lol, some natural ( . Y . ) lover modded me down. Come on, that was worth a +2 funny at least.

    6. Re:So... by Hal_Porter · · Score: 4, Funny

      You fancy a kale smoothie for lunch. Also for dinner.

      This post sponsored by the Kale Marketing Board.

      --
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    7. Re:So... by Anonymous Coward · · Score: 1

      Kale is NEVER safe to eat.

    8. Re:So... by Anonymous Coward · · Score: 0

      It's well established as a chemotherapy drug, mainly being used for certain leukemias.

      As far as chemotherapy goes, it's not as bad as many, but it certainly has fatal or potentially fatal side-effects.

    9. Re:So... by Anonymous Coward · · Score: 0

      I think you meant margarine. Mmm...doesn't semi-solidified plant oils sound tasty vs butterfat whipping? Didn't think so either.

    10. Re:So... by grep+-v+'.*'+* · · Score: 1

      I've got cancer (currently being treated, level 2 out of 4) and that's exactly what I'm doing. I'm blaming asparagus for my condition, and consider myself LUCKY that I haven't accidentally touched more and made myself even worse.

      Ok, this is broccoli, but you get the idea.

      --
      If the universe is someone's simulation -- does that mean the stars are just stuck pixels?
    11. Re:So... by Anonymous Coward · · Score: 0

      tobacco has anti cancer properties, as does corn whiskey. and firearms. the CDC will be merging with ATF shortly

  2. "How Does the Media Get Something So Wrong" by Anonymous Coward · · Score: 5, Informative

    Straight to the blowing stuff out of proportion department...
    https://www.acsh.org/news/2018/02/08/no-asparagus-wont-give-you-cancer-12546

    1. Re:"How Does the Media Get Something So Wrong" by ReeceTarbert · · Score: 1

      Where are the mod points when I need them? ;-)

      Please, mod +1 informative!

      RT.

    2. Re:"How Does the Media Get Something So Wrong" by Tx · · Score: 4, Insightful

      Welcome to the clickbait age. "Widely used leukemia drug may help slow spread of other cancers also" might get some clicks in bio-medical circles, but it wouldn't draw the clicks from the wider public. But make it sound like a compound in common foods has been discovered to be linked to spreading cancer, and watch the ad impressions roll in. Even relatively respectable publications just can't resist that kind of thing these days.

      --
      Oh no... it's the future.
    3. Re:"How Does the Media Get Something So Wrong" by Anonymous Coward · · Score: 2, Informative

      The acsh headline is more crap than the guardian article, which doesn't say it causes cancer ... it says it causes the spread of existing breast cancer into other tissues. which was already known for the most part.

    4. Re:"How Does the Media Get Something So Wrong" by KozmoStevnNaut · · Score: 3

      If there was a "+6, Correcting severe misinformation in the headline and summary" mod point I could give you, I would.

      Thank you for giving us the facts.

      --
      Eat the rich.
    5. Re:"How Does the Media Get Something So Wrong" by Anonymous Coward · · Score: 0

      "But make it sound like a compound in common foods has been discovered to be linked to spreading cancer, and watch the ad impressions roll in."

      I read the ACSH article above and the abstract from the Nature paper. As far as I can tell, "a compound in common foods has been discovered to be linked to spreading cancer" is a completely accurate description of this research. I suppose you could argue that including "in common foods" is sensationalist, but given that the research specifically looked for, and found, evidence that variations in diets influenced metastisis rates, it doesn't seem that awful to me. The title of the Nature article is "Asparagine bioavailability governs metastasis in a model of breast cancer" which could pretty much be translated directly into "a compound in common foods has been discovered to be linked to spreading cancer."

    6. Re:"How Does the Media Get Something So Wrong" by dgatwood · · Score: 1

      If your body produced sugar by photosynthesis, you'd have a point.

      --

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  3. I wish this had been discovered... by hyades1 · · Score: 1

    ...three years ago.

    --
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    1. Re:I wish this had been discovered... by Anonymous Coward · · Score: 0

      almost, the orignal report is from 2016, just went available online

  4. Aspergers causes cancer by skovnymfe · · Score: 1, Troll

    I knew it.

    1. Re:Aspergers causes cancer by Anonymous Coward · · Score: 0

      The aqueduct?

    2. Re: Aspergers causes cancer by Anonymous Coward · · Score: 0

      Mathematics.

  5. potatoes and soy is the world's #1 food by Anonymous Coward · · Score: 0

    99% of the world consumes (unknowningly) a ridiculous amount of soy products.
    The remaingin 1% / The Dutch only eat potatoes (since the last 20 decades).
    So what does the world need to eat to avoid this issue?

    1. Re: potatoes and soy is the world's #1 food by hyades1 · · Score: 4, Funny

      "The Dutch only eat potatoes...So what does the world need to eat to avoid this issue?"

      The Dutch

      --
      I've calculated my velocity with such exquisite precision that I have no idea where I am.
    2. Re: potatoes and soy is the world's #1 food by Anonymous Coward · · Score: 0, Offtopic

      You know that meat (like virtually anything else with proteins) also has it, don't you?

    3. Re: potatoes and soy is the world's #1 food by Anonymous Coward · · Score: 0

      99.76% of the world consumes (unknowningly) a ridiculous amount of soy products.
      The remaingin 0.24% / The Dutch only eat potatoes (since the last 20 decades).

      FTFY. You are less than a quarter as important as you think you are.

  6. But Asparagus is still nasty! by Anonymous Coward · · Score: 0, Funny

    Hated the taste all my life. Makes me gag. Give me broccoli and Brussels sprouts any day over Asparagus. Those veggies are delicious.

    Cancer from Asparagus? Not likely, at least in the amounts a human would really eat.

    But nothing, even half a pound of cheese smothering the Asparagus will help make it taste non-nasty!

    1. Re:But Asparagus is still nasty! by Anonymous Coward · · Score: 0, Insightful

      Fun fact, asparagus changes how women taste - usually their partners don't like the change.

    2. Re:But Asparagus is still nasty! by Impy+the+Impiuos+Imp · · Score: 0

      Most people cook asparagus until it's mush. Boil for ~3 min, long enough to take off the raw but still be bright and colorful green. Don't need salt or butter or any other coverup.

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    3. Re:But Asparagus is still nasty! by XxtraLarGe · · Score: 1, Informative

      I love asparagus.PictSweet Steamables are one of my go-to veggies for the week. It's still nice & firm after it's been microwaved. The only thing I don't like about it is the nasty side effect.

      --
      Taking guns away from the 99% gives the 1% 100% of the power.
    4. Re:But Asparagus is still nasty! by itsdapead · · Score: 0

      Plus, even reading about someone discussing how they once looked at a picture of a piece of asparagus... makes your piss stink for 24 hours.

      I mean, seriously, I could understand it if you ate a bowlful of the stuff*, but even a couple of tiny bits in a slice of quiche or mixed vegetables and, an hour later, its "I'd give that 5 minutes if I were you". Don't let the homeopaths get hold of this: a 1:10000 dilution would probably take out a city block! (* c.f. "note to self - you had seconds of the beet salad last night so no, you're not bleeding internally - but sadly its the wrong colour to cure your malaria!")

      --
      In a survey of 100 programmers, 111111 thought that duck-typing was a good idea.
    5. Re:But Asparagus is still nasty! by omnichad · · Score: 0

      Cheese on asparagus would be disgusting - and I like asparagus. Grilled until tender, but not mushy, is one of the better ways to eat it. I marinate and heat in the marinade on low heat for a while and then put it on the grill for a few minutes. If it doesn't still have any crispness to it, it's overcooked and will taste strongly of bitter compounds.

    6. Re: But Asparagus is still nasty! by Anonymous Coward · · Score: 0

      Fortunately, most Slashdot denizens won't have to worry about that. Is it related to asparagus wee?

    7. Re:But Asparagus is still nasty! by burningcpu · · Score: 1

      This is the same for men. I run from a toilet after I've pissed asparagus effluent. Stank!

  7. Re:Knew it! by haruchai · · Score: 1, Offtopic

    I knew that Asparagus was the devil's vegetable, not only is it disgusting, it makes your pee smell bad too. Any "food" that does this simply couldn't be healthy.
    Oh but we're f*cked.
    "Asparagine is present in plants proteins in large amount.
    Animal sources: dairy, whey, beef, poultry, eggs, fish, lactalbumin, seafood.
    Plant sources: asparagus, potatoes, legumes, nuts, seeds, soy, whole grains. Asparagine is found in potatoes so eating French fries will give you asparagine along with starch. It is also found on roasted coffee."

    In other words, EVERYTHING causes cancer

    --
    Pain is merely failure leaving the body
  8. Many common foods by HalAtWork · · Score: 2

    Nuts, whole grains, seeds, eggs, soy, potatoes, legumes, poultry, dairy, beef, seafood.

    That's a lot to avoid. I wonder which are highest in asparagine, then perhaps having less of the highest ranking ones would be a start.

    1. Re:Many common foods by turp182 · · Score: 1

      Not as much to avoid as common noises, which might cause heart disease...

      http://abcnews.go.com/Health/e...

      Of course the world death rate is still at 100%:
      https://www.theonion.com/world...

      --
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  9. Research : this just in by houghi · · Score: 2

    This just came in :
    Research causes cancer in rats. More news at 11:00.

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  10. "How Does the Public Get Something So Wrong" by Anonymous Coward · · Score: 0

    Of course. Since the public at large will only pay for the absolutes they can get away with, media at large has to resort to "persuasive" means to pay their bills. Just think of what the internet would be like if people actually payed for things they found useful in their lives, instead of trying to wiggle out of doing so every chance they got like it's some kind of punishment.

    1. Re:"How Does the Public Get Something So Wrong" by Anonymous Coward · · Score: 0

      If you want to sell me something, offer it for sale and see if I want to buy.
      Don't pretend it's gratis, then try to get me to pay later.

  11. Amino acids and cinder blocks by Anonymous Coward · · Score: 0

    Just because some uses them to construct buildings for nefarious purposes, doesnâ(TM)t automatically mean cinder blocks are bad.

  12. Curse you Carbon, Oxygen and Hydrogen! by jellomizer · · Score: 3, Insightful

    These three elements seem to be the root cause of nearly every illness. Yet they use them all the time in our food, and our body has a large concentration of this in our systems ready to kill us at any time.

    --
    If something is so important that you feel the need to post it on the internet... It probably isn't that important.
    1. Re:Curse you Carbon, Oxygen and Hydrogen! by Anonymous Coward · · Score: 0

      A perfect example of what Jello is talking about is the rampant use of Dihydrogen Monoxide(DHMO) in practically every product you've consumed. DHMO is a highly reactive solvent used to help "thin" our foods down so that Monsanto and other megacorps can cheapen out on using real food products. Furthermore, it has been found to be an effective, but highly dangerous, growth accelerant in modern GMO crops and so is being sprayed by the millions of gallons directly onto the food we eat. Something you might not hear about (WAKE UP SHEEPLE) are the hundreds of farm deaths involving DHMO asphyxiation. Hard working folks, just like you, dying to put food on the table. WHEN WILL IT STOP??????????

  13. Kids Agree! by sycodon · · Score: 2

    Vegetables, especially Asparagus, will Kill You!!

    --
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  14. Soy by Anonymous Coward · · Score: 0

    Soy is now in a large number of prepared foods. People probably eat 1000x more soy than asparagus. If the compound is a real problem why wasn't soy in the title? That would be a lot more informative.

    1. Re:Soy by Hal_Porter · · Score: 1

      Because (((they))) want you to eat soy to lower your testosterone levels. Stick to Super Male Vitality, stay woke.

      --
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  15. Over simplified by DaMattster · · Score: 1

    I am not surprised that there may be some compounds in foods that can cause cancer. But what we do not know is how they do and with what other compounds they must mix with in order to potentially cause cancer. If you eat a crappy diet and take some supplements that are purported to prevent cancer, you can still end up getting cancer because the compounds that are supposed to fight cancer react totally differently when mixed with the crappy foods.

  16. Low vitamin d by Anonymous Coward · · Score: 0

    Notice how all these health problems got so bad after the dermatoligists told everyone to stay inside or if you must be outside wear sunscreen, hats, long sleeves etc.

    Vitamin d helps a lot of stuff.

  17. Wait just a minute by kilodelta · · Score: 1

    So meats, vegetables and dairy products - all they left out is fruits. Sort of like what I say about vegans - if they pull the moral superiority card out I mention that trees and plants also communicate, reproduce etc. They're just as alive as say a chicken or us. So eat air.

    1. Re:Wait just a minute by Anonymous Coward · · Score: 0

      Sort of like what I say about vegans

      I spend almost 20 years as a vegetarian .. and during that entire time I still thought vegans were smug idiots with no clue, and those PETA clowns were the worst.

      Those 'vegan' shoes of yours? They're made of a bunch of nasty petrochemicals, so I guess you'd rather keep fucking up the environment, right? Same for that pleather purse you're carrying. It's all shit from the oil industry, so stop braying about the environment.

      Until they're wearing fucking banana leaves and corn husks on their feet, don't take them seriously. And don't be a smug douche using your cell phone to post on the interwebs about animal cruelty until you stop to consider the environmental impact of all of the heavy metals in that damned phone.

      Even when I was a vegetarian vegans were annoying as fuck. Now that I'm not a vegetarian, I have zero patience for their bullshit.

  18. Limit any fundamental building block ... by Anonymous Coward · · Score: 0

    Cancers need the same fundamental chemicals that healthy cells need to grow. It makes sense to target a fundamental building block that affects cancer more than healthy cells. However, if you take this too far or for too long and you will kill the host, so this is not a cure. More and more cancers are becoming "managed" and fundamental amino acid suppression could be a another management tool. What is breast cancer's second most observed amino acid? Limit intake and take high doses of L-asparaginase for two weeks and then for a week take high doses of the second enzyme and then back to L-asparaginase for a two weeks. This way you hinder the cancer while giving the host's healthy cells the ability to recover somewhat.

  19. ORLY by Anonymous Coward · · Score: 0

    Soon to be read: "Food consumption causes cancer. Stop eating now!"

  20. Something a little more promising is... by Maelwryth · · Score: 1

    This.

    Injecting minute amounts of two immune-stimulating agents directly into solid tumors in mice can eliminate all traces of cancer in the animals, including distant, untreated metastases, according to a study by researchers at the Stanford University School of Medicine.

    --
    I reserve the write to mangle english.
    1. Re:Something a little more promising is... by Maelwryth · · Score: 1
      --
      I reserve the write to mangle english.
  21. Ah, so that's pee cancer... by kimgkimg · · Score: 1

    I knew something smelled funny.

  22. Comment removed by account_deleted · · Score: 1

    Comment removed based on user account deletion

  23. Everything can kill us by Anonymous Coward · · Score: 0

    So what you're telling me is that literally everything in this world is made to kill us in some way. Nuts and veggies were the last straw...

  24. Re: GREASY YODA DOLL UP MY ASS! GO LINUX! by Anonymous Coward · · Score: 0

    I suppose it's better you spend your time doing this rather than trying to interact with human beings in real life.

  25. Asparagus Formerly Believed to Reduce Cancer! by Anonymous Coward · · Score: 0

    My brother-in-law was told to eat buckets of asparagus by the cancer doctors. Guess that was a bad idea. He died 4 years after the first diagnosis.

  26. Big Cancer is big business by Anonymous Coward · · Score: 0

    Never give a penny to the mainstream "anti-cancer" research groups.

    These Big Pharma shills actually want us to believe that all natural fruits and vegetables are giving us cancer, but that high-fructose corn syrup, pharmaceutical drugs and diet soda are just fine.

    Who actually believes this crap?