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Fasting Can Improve Overall Health By Causing Circadian Clocks In the Liver and Skeletal Muscle To Rewire Their Metabolism, Study Finds (sciencedaily.com)

An anonymous reader quotes a report from ScienceDaily: In a University of California, Irvine-led study, researchers found evidence that fasting affects circadian clocks in the liver and skeletal muscle, causing them to rewire their metabolism, which can ultimately lead to improved health and protection against aging-associated diseases. The study was published recently in Cell Reports. The research was conducted using mice, which were subjected to 24-hour periods of fasting. While fasting, researchers noted the mice exhibited a reduction in oxygen consumption (VO2), respiratory exchange ratio (RER), and energy expenditure, all of which were completely abolished by refeeding, which parallels results observed in humans.

"The reorganization of gene regulation by fasting could prime the genome to a more permissive state to anticipate upcoming food intake and thereby drive a new rhythmic cycle of gene expression. In other words, fasting is able to essentially reprogram a variety of cellular responses. Therefore, optimal fasting in a timed manner would be strategic to positively affect cellular functions and ultimately benefiting health and protecting against aging-associated diseases." This study opens new avenues of investigation that could ultimately lead to the development of nutritional strategies to improve health in humans.

216 comments

  1. What no anteaters? by Anonymous Coward · · Score: 2, Funny

    Shouldn't UC Irvine be testing on anteaters, not rats?

    1. Re: What no anteaters? by Anonymous Coward · · Score: 0

      A few people have been saying lately that slashdot is deleting some posts. If that's true then why don't they have a script to match this repeated swastika BS and delete it?

    2. Re: What no anteaters? by aliquis · · Score: 1

      So free universities in US too?

      Kinda sound like you admit that only indoctrination can "cure" white supremacy. Like... The solution isn't others catch up and achieve and compete and create societies on par with ours but rather we need to be "re-educated" to forget that we are superior.

    3. Re:What no anteaters? by Anonymous Coward · · Score: 0

      It's interesting. Who's going to put people in concentration camps first: people who support Trump (not all of them or even a majority of them are white supramecists) or people who are against Trump?

      Anybody remember that when Trump got elected that there were cries that he was going to put all sorts of people into "literal" concentration camps? We're roughly at the 50% point in his four-year term and not one person has been sent into a concentration camp by the Trump administration. Or anyone for that matter being that there are no concentration camps in the U.S.

    4. Re: What no anteaters? by Anonymous Coward · · Score: 0

      The same meme happens when every president gets elected.

      When Obama was elected I had friends sending me "spy satalite" photos of fema camps that were being setup. Apparently Obama's plan was to declare marshal law, make himself president for life, and put all white people in fema camps.

      Yea that worked out real well.

    5. Re: What no anteaters? by Anonymous Coward · · Score: 0

      Your mamma knows better

    6. Re: What no anteaters? by ChrisMaple · · Score: 1

      The illiteracy is strong in this one.

      --
      Contribute to civilization: ari.aynrand.org/donate
  2. Don't like the science? Wait a few years by doubledown00 · · Score: 2, Interesting

    The newest diet fad is "intermittent fasting". 20 years ago it was "skipping breakfast" and was bad for you.

    "1,500 years ago, everybody knew that the Earth was the center of the universe. 500 years ago, everybody knew that the Earth was flat. And 15 minutes ago, you knew that humans were alone on this planet. Imagine what you'll know tomorrow."

    1. Re: Don't like the science? Wait a few years by Anonymous Coward · · Score: 0

      Skipping breakfast is still bad for you.

    2. Re: Don't like the science? Wait a few years by Xarin · · Score: 1

      Skipping eating everything after 7PM works though. Itâ(TM)s all those snacks after dinner that add up.

  3. Re:Don't like the science? Wait a few years by DontBeAMoran · · Score: 2

    I follow this new fad called "I only eat when I'm hungry".

    I got to tell you, so far it's really going greaH&goyLUKHgZZZzzzz....

    --
    #DeleteFacebook
  4. I have noticed by Beeftopia · · Score: 4, Interesting

    I have noticed that dropping my calories way down for a day leads to dramatically improved sleep. FWIW, YMMV, etc.

    1. Re:I have noticed by Anonymous Coward · · Score: 0

      Same. I wanted to get fit/lose weight last year.

      I initially tried the recommended approach to things - make all meals healthy, a regular exercise regime etc - and it (a) was practically impossible to keep up after a few months (your brain fights back and tries all sorts of dirty tricks to convince you to eat more and move less) and (b) *really* messed with sleep (roughly: trying to get to sleep when hungry is hard).

      Then out of desperation I decided to try once-a-week-fasting and shorter, high-intensity workouts, with normal eating and activity the rest of the time, and found it (a) *much* easier to stick to, (b) didn't mess with my sleep (except on the fast day but whatever - once a week beats every night) and (c) was vastly, miles away more effective than the recommended approach: as in I actually lost weight and got objectively (measurably) fitter.

      FWIW, YMMV, IANOD etc etc, but that's my experience.

    2. Re:I have noticed by Anonymous Coward · · Score: 0

      I tried 16/8 intermittent fasting and found my mental clarity improved noticeably.

    3. Re:I have noticed by Anonymous Coward · · Score: 0

      I notice the opposite. Eating too little during the day causes me to not have a deep sleep. It's almost like I'm half awake most of the night and aware of it. The dreams are a bit more intense as well.

    4. Re:I have noticed by Anonymous Coward · · Score: 0

      On a typical fasting regimen, you're eating the same number of calories as you would if you weren't fasting, it's the hours that you eat them that's restricted.

      Some of them are somewhat reduced in calories, but I haven't seen a credible one that cuts the calories by any significant amount over the long term, except when trying to lose weight until one has lost the weight.

    5. Re:I have noticed by grep+-v+'.*'+* · · Score: 1

      I have noticed that dropping my calories way down for a day leads to dramatically improved sleep

      I have noticed that dropping MY calories way down, say to 0, permanently leads to DRAMATICALLY improved sleep -- why, I'm dead to the world.

      --
      If the universe is someone's simulation -- does that mean the stars are just stuck pixels?
    6. Re:I have noticed by Anonymous Coward · · Score: 0

      Yet here you are, alive and producing coherent sentences.

  5. Re:Don't like the science? Wait a few years by js290 · · Score: 3, Insightful

    The old religions have known about fasting for millennia. Science is way behind.

    --
    "Tempers are wearing thin. Let's just hope some robot doesn't kill everybody." --Bender
  6. Fasting worked wonders for my health. by Cobratek · · Score: 5, Interesting

    This was worth logging in for.

    I was overweight and staring down 50, so I did some research and decided to try it.

    I did a 7 day water fast followed by a mostly keto style diet, but really just sticking to food that's been on the planet for longer than 100 years, no processed chemical foods. I lost maybe 10 pounds during that week but the weight just kept falling off.  Down from 40's to 34's and even 32's after about 9 months of sticking to real food, cut back(not out) on sugar and bread.  My blood panels showed no problems with cholesterol etc after eating bacon and eggs for breakfast for months.  homemade soups etc for dinner.

    Fasting is part of a natural cycle, your body uses the time when digestion is shut down to heal itself.

    Don't believe me, prove me wrong.

    --
    DONT TREAD ON ME MOÎΩN ÎABÃ
    1. Re: Fasting worked wonders for my health. by Anonymous Coward · · Score: 0

      Yeah I do at least one 10 day water fast every year. I've been banging on about it for years to anyone who'll listen. I wish my father had of tried one instead of getting a quintuple bypass. In the future people will look back in wonder that we used to perform open heart surgery on people instead of just letting their body consume their blockages.

    2. Re:Fasting worked wonders for my health. by Pinky's+Brain · · Score: 1, Flamebait

      Having been a fatso a priori eliminates you as someone suitable to give diet advice, dieting maybe ... but not diet.

      Leave healthy people alone and stick with your own, fatties.

    3. Re:Fasting worked wonders for my health. by Anonymous Coward · · Score: 0, Flamebait

      Seems not many notice the sarcasm.
      just sticking to food that's been on the planet for longer than 100 years
      All human food ingredient exist on earth for more than 100 years. But few can screen out further domestication.

      No processed chemical foods
      All cooking process involve chemical transformation.

      Down from 40's to 34's and even 32's after about 9 months of sticking to real food
      32 pounds = 14.5kg. Weight of a 8 years old kid.

      Don't believe me, prove me wrong.
      Unless one with a gene that growth no taller than 3 feets, 40 pounds basically spell mulnutritions.

    4. Re:Fasting worked wonders for my health. by thegarbz · · Score: 1

      but really just sticking to food that's been on the planet for longer than 100 years

      I can't remember us synthesising new food in labs (except maybe vegan not burgers). Your choice is arbitrary and doesn't help understanding of the issues at play.

    5. Re:Fasting worked wonders for my health. by froggyjojodaddy · · Score: 2

      I did something similar with intermittent fasting and was able to achieve my goals. I was turning 40 and tipped the scales at around 240 lbs. I read A LOT , watched a bunch of YouTube videos, scoured health forums to get an idea of what worked for others. Unfortunately, my doctor was useless in this regard so I relied on the Internet to give some guidance

      Here's my routine .. DISCLAIMER: This worked for me, it might not work for you. YMMV:

      - Start off on Atkins/Keto diet. Cut out all sugars/carbs. Really, really difficult to do but you have to push yourself. I ate Atkins bars and veggies mostly.
      - Restrict diet to 1,100 calories daily. Track this via the FitBit app. If it didn't have a barcode or wasn't in the FitBit database, I didn't eat it
      - Joined a gym. Went 6/7 days and worked out until my FitBit said I burned 800 calories. Combination of weights and cardio. I found the treadmill really hard on my shins and knees but the stairclimber is great and really got my heart in the peak zone quickly
      - intermittent fasting! . I would eat my 1,100 calories on Monday, intermittent fast on Tues (only water or Coke Zero) and a very small bag of celery, cucumber that would last me the entire day IF I felt I needed to dip into it. Back to regular diet on Wed, and then skip a day. Fasting was difficult the first week or so, my body was actively craving food.

      In a year, I dropped 60 lbs. My weight lifting pretty much tripled across the board, except for squats. I still have a hard time with squats and ALWAYS get DOMS. Speed on the stairclimber went from 4 to 14 e.g. I can maintain speed 14 out of 20 for a full hour.

      The intermittent fasting really helped - I kept a diary of my weight loss. 2 weeks I would just maintain my 1,100 calories and then switch to alternating fasting days for two weeks. The two weeks with fasting resulted in faster weight loss, but at the expense of some energy drain. I don't know if that was psychological, but it FELT like it was harder to work out for sure. One thing I'll point out is after the fasting day, I didn't feel hungry the next day - I forced myself to eat something as part of my diet tracking but more often than not, I didn't feel hungry enough to eat

      Right now, I'm 42 and maintaining a body weight of ~165 lbs. Still going to the gym 5/7 days (the two off days are recovering from DOMS after leg day and one day just to recuperate after intense cardio. I don't feel like I need to rest after a cardio day but that's what most other people do)

    6. Re:Fasting worked wonders for my health. by doubledown00 · · Score: 4, Insightful

      Down from 40's to 34's and even 32's after about 9 months of sticking to real food 32 pounds = 14.5kg. Weight of a 8 years old kid.

      Don't believe me, prove me wrong. Unless one with a gene that growth no taller than 3 feets, 40 pounds basically spell mulnutritions.

      I could be wrong, but I gather the comment was referring to pant sizes.

    7. Re:Fasting worked wonders for my health. by Eldaar · · Score: 1

      I agree that fasting in various forms can do wonders for your health. The more I've looked into it, the more studies there are that demonstrate some of the effects it can have at the cellular level.

      Many of the studies are done on mice, whose circadian rhythm and metabolism are certainly different from humans. But the general thrust seems to be that when we fast, our bodies do things like engaging in autophagy (repairing somewhat damaged cells and entirely replacing very damaged cells) and increasing hormones that spur muscle growth. Dr. Berg and an athlete named Thomas Delauer have some basic explanations on YouTube about how some of this works.

      This makes some intuitive sense, too. From an evolutionary standpoint, humans weren't doing what many people do nowadays: eating right after or shortly after waking up, and continuing to eat throughout the day until shorlty before going to sleep. We just didn't have that much food, so prior to the agricultural revolution, we probably went several hours throughout the day with no food at all. Or we may have gone a day or several days without food.

      Another way of thinking about it is that, if you never fast, your body is constantly spending resources to process food. If you give it a break from food now and then, it can spend more resources doing things other than digesting food - things like repairing cells.

      Anecdotally, I've been doing intermittent fasting for a few weeks, wherein Monday through Friday I only eat from 12:30pm to 8:30pm. On the weekends, I eat whenever I feel like it. This means my fast each weekday is the remaining 16 hours that I'm not eating. And since starting this regimen, my muscles having been growing faster than I've ever seen before (I do some calisthenics like pull ups, dips, leg raises, and pushups). This could be due to increased hormones for muscle growth.

    8. Re:Fasting worked wonders for my health. by Anonymous Coward · · Score: 0

      Wheat , soy, corn, potatoes, tomatoes, all are now mainstream gmo. That is what he means by lab food, not to mention the many additives (whipped up in labs) used in food production.

    9. Re:Fasting worked wonders for my health. by Anonymous Coward · · Score: 0

      Yep. Fasting made him really short in just 9 months! X^D

      (j/k. I know he's referring to waist size.)

    10. Re:Fasting worked wonders for my health. by ShanghaiBill · · Score: 1

      Wheat , soy, corn, potatoes, tomatoes, all are now mainstream gmo.

      Nitpick: There is no GMO wheat grown commercially anywhere in the world.

    11. Re:Fasting worked wonders for my health. by Insanity+Defense · · Score: 1

      Unless one with a gene that growth no taller than 3 feets, 40 pounds basically spell mulnutritions.

      Alternately he meant waist size in inches.

    12. Re: Fasting worked wonders for my health. by Anonymous Coward · · Score: 0

      Just started

      http://mobile.dudasite.com/site/preventdisease?url=https%3A%2F%2Fwww.preventdisease.com%2Fnews%2F12%2F040712_First-Genetically-Modified-Wheat-To-Be-Introduced-Into-Commercial-Market.shtml&utm_referrer=https%3A%2F%2Fduckduckgo.com%2F#2801

    13. Re:Fasting worked wonders for my health. by philmarcracken · · Score: 1

      Here's my routine .. DISCLAIMER: This worked for me, it might not work for you.

      - Restrict diet to 1,100 calories daily. Track this via the FitBit app. If it didn't have a barcode or wasn't in the FitBit database, I didn't eat it

      That was the only thing you needed to do to lose weight. And you don't need the disclaimer; it works for everybody unless they are terrible at counting kcal.

    14. Re:Fasting worked wonders for my health. by s4080326 · · Score: 1

      Could be Stone and he was and still is one seriously large bastard

    15. Re:Fasting worked wonders for my health. by Anonymous Coward · · Score: 0

      he's talking about his pant size, not mass lost.

    16. Re:Fasting worked wonders for my health. by froggyjojodaddy · · Score: 1

      Well, I'd like to think the working out helped my health too. I mean, I saw actual, tangible results in terms of my weight lifting ability and ability to run / cycle / climb stairs without getting winded. I don't think that would have been possible on a diet-only strategy

      Also, I don't fully understand the biological process behind the intermittent fasting but I can only talk about my personal results, hence the YMMV. I think with a reduction in caloric intake, there's a corresponding decrease in metabolism. That is, your body realizes you're intaking far fewer calories than normal and it makes certain adjustments so going from 2,400 calories to 1,100 calories works for a while, but then your body just gets used to 1,100 so your weight loss either plateaus or slows down.

      I was able to actually measure the slow down in weight loss via my diary depending if it was an intermittent fasting week or not. And I kept a very regimented diet. It was essentially the same food each and every day. No variation.

      Breakfast: 2 egg whites
      Mid-morning snack: 2 celery sticks cut in 3 pieces each. 5 slices of cucumber, 5 cherry tomatoes, 5 baby carrots
      Lunch: Pure Protein bar. 1 335ml can of Coke Zero
      Mid-afternoon snack: 10 raw almonds, small bowl of raw spinach
      Dinner: 1 piece chicken breast, small piece of steak, side of steamed veggies. 300ml water with metamucil powder. Costco protein shake


      I'm sure a good biologist / dietitian could actually explain my results in a way that would make sense but in the absence of that, I'm just talking about my personal achievement, measured rather religiously each and every day.

    17. Re:Fasting worked wonders for my health. by philmarcracken · · Score: 1

      Well, I'd like to think the working out helped my health too. I mean, I saw actual, tangible results in terms of my weight lifting ability and ability to run / cycle / climb stairs without getting winded. I don't think that would have been possible on a diet-only strategy>

      Correct, but I wasn't talking about fitness level, just weightloss.

      Also, I don't fully understand the biological process behind the intermittent fasting but I can only talk about my personal results, hence the YMMV. I think with a reduction in caloric intake, there's a corresponding decrease in metabolism. That is, your body realizes you're intaking far fewer calories than normal and it makes certain adjustments so going from 2,400 calories to 1,100 calories works for a while, but then your body just gets used to 1,100 so your weight loss either plateaus or slows down.

      That doesn't happen. The body doesn't 'get used' to fewer kcal, it drops in response to less total mass of you demanding energy. It will never cross to 1100 kcal, even if you're a short woman. Even if you're comatose. Your organs, brain and body heat require energy and it must come from bodyfat or what you're eating.

      If anybody drops their daily kcal to 1100 they will lose weight, regardless of exercise, medications, genetics, type of food, gender or even largely age. Its too few a TDEE value for the majority of adults.

  7. Re:Don't like the science? Wait a few years by Ichijo · · Score: 5, Informative

    500 years ago, everybody knew that the Earth was flat.

    False.

    --
    Any sufficiently unpopular but cohesive argument is indistinguishable from trolling.
  8. 3 square meals a day is unnatural by js290 · · Score: 1

    Probabilistic structure for fasting http://bit.ly/2ivHC5d

    --
    "Tempers are wearing thin. Let's just hope some robot doesn't kill everybody." --Bender
  9. Re:Don't like the science? Wait a few years by Shaitan · · Score: 5, Informative

    It's a quote from the movie Men in Black

  10. wonderful news by iggymanz · · Score: 1

    for making a rodent healthier.

    primates? who knows....

    1. Re:wonderful news by Anonymous Coward · · Score: 0

      The research that's been done is pretty conclusive that humans should have regular periods of fasting. Eat Stop Eat is based on a rather comprehensive review of the literature that's been done.

      Most of the things that people claim about fasting have no basis in research. You don't lose muscle when fasting, unless you're not using the muscle. And you can go a surprising length of time without eating and still be healthy. There are obviously limits to what the human body can handle without permanent damage, but they're a lot further out than people realize.

      I was once sick and couldn't keep more than a cup of yogurt down per day. And that went on for about a month. I lost a ton of weight and muscle doing that, but if I knew then what I know now, I probably wouldn't have lost anywhere near as much muscle mass doing it.

    2. Re:wonderful news by Anonymous Coward · · Score: 0

      for making a rodent healthier.

      primates? who knows....

      I do, yes. At least in my experiment sample size of 1. It's just food. This isn't some experimental drug testing that you need a PhD just to pronounce correctly.

      Design your own experiment, approach it logically and scientifically. I kept a log recording weights of foods I ate, my body weight, blood glucose (cheap), bHB levels (not so cheap), blood pressure, and notes such as amount of sleep and any "feelings" crap like "upset stomach", "really hungry", "not hungry", "headache", "light headed", etc. You will most likely feel bad for a couple weeks if you try keto-adapting. They call it "keto flu".

      I decided to do my experiment after my doctor said my A1C was so high she wanted to put me on insulin. I was borderline and convinced her to let me try changes in diet and exercise for 6 months, and if I didn't improve I would take the drugs. (Spoiler: I'm so glad I didn't take the drugs.) My experiment included a few weeks of keeping records with no changes, then after getting a control/baseline to compare to I started making adjustments. I set my macro goals with the intention of getting my bHB up to 1.0-3.5 within 3 weeks. (Beta-hydroxybutyrate is the blood marker that indicates you are functioning on fat-based metabolism, and is normally under 0.5 while the body is running on glucose-based metabolism.) Glucose test strips are like $0.06 each, but bHB test strips are more like $3.00 each, so that sucked a bit. Anyway, at 20g/day of carb it took me about 2 weeks to adapt. Might just be my genetic disposition. I certainly wouldn't be showing signs of diabetes at my age if I was one of the 20% or so of the population that seem to be immune to carb/insulin troubles no matter what they eat.

      Intermittent fasting becomes part of the keto diet almost automatically. Many people describe a prescribed diet as a horrible experience since they tend to feel hungry all the time. For me keto reset my hunger sense. I would eat tasty high fat and low to moderate protein foods that I like and would not feel hungry after, unlike the Chinese food stereotype. Once I got comfortable with my rediscovered sense of hunger I was able to break away from the 3meals + 2 snacks per day standard schedule. I would eat only when hungry, and I would eat as much as I felt like eating when I did. This is all recorded over several months of my experiment log books. The oddest case was not feeling hungry for 3 days then eating about 8,000kCal in one sitting. (It was a large party with an amazing buffet.) After adapting my metabolism I had no dizziness from hunger or sleepiness from eating so much. It just felt good to eat when hungry.

      And yes, you don't always know down to the gram what you are eating when you are not preparing the food. The simple solution is, don't eat out. Just prepare all your own food. One of the startling things at first was my lack of portioning skill in the kitchen. As I had never cared to measure food accurately before, and I was always hungry before, my meal prep had crept up where I had been cooking 12oz of chicken and feeling like it was a normal portion to feel full. Seriously, using a scale and limiting portions to 4-6oz may help some people all on it's own. After months of cooking with the scale you recalibrate your eye and will see that restaurants often do this too.

      So what was the result of my experiment? You may know that A1C is a reflection of the glycation process and due to rates of cellular decay and regeneration it makes a decent reflection of average blood glucose levels over about 6 months. She also ordered full panels with cholesterol and loads of other stuff I don't care about. When she got the results she was shocked. I had lost 40lbs and every single marker in the panel had improved significantly. She said I looked 20 years younger on paper, and asked me for my research reference list (about 60 books and journal articles) and my data log.

      This is not

    3. Re:wonderful news by iggymanz · · Score: 1

      Congrats on the health benefits but as far as fasting...sorry but you changed a LOT of things besides the fasting. So you don't even have an experiment of 1 on the subject of fasting.

      I'll even go so far as people have done what you have done, without the fasting, and the excess body fat and blood sugar go waaay down. I know this from my experience.

    4. Re:wonderful news by ChrisMaple · · Score: 1

      I was borderline and convinced her to let me try changes in diet

      It's your life. You don't have to convince your doctor of anything if you intend not to do something such as not taking a particular drug or not submitting to surgery. The doctor isn't your boss.

      --
      Contribute to civilization: ari.aynrand.org/donate
  11. Re:Don't like the science? Wait a few years by Synon · · Score: 2

    Only one way to find out... I started the "fad" a couple weeks ago, restricting my eating time to 8 hours a day and 16 hours of fasting with some 24+ hours fasts thrown in here and there. I'm less concerted about weight loss and more focused on cholesterol and an A1C that puts my blood glucose levels on the edge of pre-diabetic. I'm decently fit and athletic, healthy diet, middle of the "healthy weight" for my height and sex. I plan to fast this way every day for 3 months, though still keeping my typical diet, and get some bloodwork done to see if my numbers improve at all. It does seem effective for weight loss even though that's not my focus. It's a much easier plan to follow than calorie restriction, I just eat when I'm hungry during my 8 hour window... but I'm not as hungry after the first few days of the fasting which is causing me to run a slight calorie deficit. Interested to see if this has any positive or negative effect on my insulin resistance and cholesterol levels, I've had bloodwork done regularly for the past 8 years so I have a pretty good baseline.

  12. Re:Don't like the science? Wait a few years by Anonymous Coward · · Score: 0

    That doesn't make it any more correct or relevant.

  13. These researchers are sadists by Anonymous Coward · · Score: 0

    The fact that the rats were compelled to fast is a confounding effect. Please review Cargo Cult Science, where Feynman talks of rat maze studies and why they are a Cargo Cult. Same applies to these rat studies.

  14. Wording in this posting sounds like pseudoscience by Anonymous Coward · · Score: 0

    Like it came from a religious chiropractor who is trying to convince you that the special food he sells will cure your cancer.

    Haa!! and my capcha is "atheism"

  15. Re:Don't like the science? Wait a few years by Anonymous Coward · · Score: 0

    oh my god fuck off

  16. Those mice weren't "fasting" by h33t+l4x0r · · Score: 0

    Those mice were "being starved."

  17. Re:Don't like the science? Wait a few years by Anonymous Coward · · Score: 2, Interesting

    In the VERY old days, periods of fasting were unavoidable. So, naturally, humans built some myths around it, as they did around basically everything. They sanctify the mundane as a psychological mechanism for coping with the existential emptiness of our existence.

    The old religions simply inherited those myths.

    It's really not surprising that they would, nor that our bodies would have some baked-in responses to this recurring survival need.

  18. Re:Don't like the science? Wait a few years by Anonymous Coward · · Score: 0

    This is completely consistent with skipping breakfast being bad for you on an everyday basis. The idea here is not to fast every day, you'd be dead, the idea is to fast every once in a while, then go back to a normal eating schedule most of the time, which may include not skipping breakfast.

  19. Intermittent Fasting Is Not a Miracle Weight Loss by MDMurphy · · Score: 1

    https://lifehacker.com/intermi... Often I'll read a topic somewhere else and see it show up on Slashdot hours or days later. When I saw this I was sure it was the post I'd read earlier in the day. Imagine my surprise to find it had the opposite conclusion.

  20. Re:Don't like the science? Wait a few years by thomst · · Score: 2

    doubledown00 pointed out:

    The newest diet fad is "intermittent fasting". 20 years ago it was "skipping breakfast" and was bad for you.

    This is purely anecdotal evidence, of course, but I'm an insuliin-dependent, Type II diabeitc. I've been "daytime fasting" (fasting a minimum of 16 hours each day) for about 8 months now.

    My weight is down about 40 lbs since I began this regimen. Just as importantly, I now need only half as much insulin per day as I did before I began fasting during the day. In fact, I have to be especially careful with my Lantus intake, because hypoglycemia is a fucking drag.

    Oh, and I "cheat" on weekends by eating sparingly during the day, to reward myself for exercising the required self-discipline during the week.

    YMMV - but it probably won't, as long as you stick to the schedule ...

    --
    Check out my novel.
  21. Re:Look for the agenda by antek9 · · Score: 5, Informative

    I know you're trolling, but allow me to bite: Vegan doctrine doesn't include fasting, moreover, vegans love carbs and get fat if they don't also afford a nutrition coach. Muslims don't know the first thing about fasting, Ramadan is a joke: not even water during daytime, only to eat triple the normal daily amount all night long is NOT intermittent fasting, it's binge eating with a cooldown phase.

    Keto and fasting (comes naturally, the hunger just goes away) for the win, and you can keep eating those steaks. But throw away the potato.

    --
    A World in a Grain of Sand / Heaven in a Wild Flower,
    Infinity in the Palm of your Hand / And Eternity in an Hour.
  22. Being Poor has its Advantages by wolfheart111 · · Score: 1

    Cant eat as much, cant buy as much alcohol or drugs... Ummm... ya. :)

    --
    [($)]
    1. Re:Being Poor has its Advantages by Powercntrl · · Score: 2

      Cant eat as much, cant buy as much alcohol or drugs...

      Actually, the healthy stuff is more expensive. I picked up 1lb of grass-fed 90% ground beef at Walmart earlier this evening, and it's $6/lb. The ground lips-and-assholes in the opaque tube (because they don't want you seeing what it looks like until you've bought it) costs about half as much, but who knows how that vile sludge ever got approved for human consumption. It pretty much also holds true for hot dogs, chicken nuggets, and anything else they can fill with animal parts that should've gone into pet food - you're going to get what you pay for.

      Furthermore, fresh fruit and veggies cost a lot more than a box of ramen, pasta, or generic instant mashed potato mix - pretty much anything that's a carbohydrate bomb. All things considered, being poor is more likely to lead to an unhealthy diet.

      --

      ---
      DRM is like antifreeze, to the MPAA/RIAA it's sweet, to the consumers it's poison.
    2. Re:Being Poor has its Advantages by Anonymous Coward · · Score: 0

      ...anything else they can fill with animal parts that should've gone into pet food...

      Uh, pet food? Have you seen the cost of animal medical treatments these days? If you think blowing your life savings treating a preventable disease is bad, imagine doing that shit to save the fucking family cat.

      Let's not do that to our pets. Some "food" isn't meant for consumption by any living creature you care about.

    3. Re: Being Poor has its Advantages by Anonymous Coward · · Score: 0

      I'd like cheap lips, but leave the assholes please.

    4. Re:Being Poor has its Advantages by Xarius · · Score: 1

      "healthy food is expensive" is a lie for the most part. It just takes slightly longer to make than an instant meal.

      In the UK you can get a bag of 7 or 8 carrots for 60p, a bunch of bananas for less than £1, a bag of onions for less than £1, most vegetables are very cheap. Some fruit are expensive but that depends on the season. You might be talking £1.60 for a bag of bananas.

      1kg of lentils for less than £2. 1kg of chopped tomatoes for less than £3. 1kg of spinach for less than £3.

      Fruit and vegetables are absurdly cheap these days.

      Sure for the same cost of all of that you can get 25 packets of cheap, barely flavoured noodles. Or you could buy half the noodles, a load of cheap vegetables, and make up a nutritious dinner.

      --
      C17H21NO4
    5. Re:Being Poor has its Advantages by apoc.famine · · Score: 1

      Extending this, outside of the holidays a whole frozen turkey around here in the US costs a bit over $1/lb, sometimes discounted under that. So a big old 16lb turkey can be had for under $20, sometimes as low as $12-$14. Roast it, cut it up, break down the skeleton and boil it with herbs and veg for stock, and for all of $20 you're going to get about 8 lbs of turkey meat and 2 gallons of soup stock.

      For each meal add some potatoes and some vegetables, and you're talking a solid 6-8 meals for a family of four, at less than $5/meal. Way more nutritious and cheaper than fast food; you just need some time and effort to make it happen.

      A whole frozen turkey is some of the cheapest high-quality protein you can get. People just don't want to put the effort into defrosting, roasting, and carving one. Once you figure out how to do that, you've got a whole lot of cheap, good eating ahead of you.

      --
      Velociraptor = Distiraptor / Timeraptor
  23. Re:prove me wrong by Anonymous Coward · · Score: 2, Insightful

    >Don't believe me, prove me wrong.

    That's not how it works. YOU make a claim, YOU provide proof.
    Your post was fine until that last sentence.

    Besides, it's impossible to prove that what worked for you won't work for others.
    You probably understand that your body might be an exception as well, just because it worked for you it won't necessarily work for others.

    This is all anecdotal, which is just fine. Just don't start asking for "disproving proof" when you provide none in the first place.

  24. Re: Don't like the science? Wait a few years by Anonymous Coward · · Score: 3, Interesting

    Skipping breakfast is impossible unless you stop eating until you starve to death.

  25. Re:Look for the agenda by Anonymous Coward · · Score: 0

    Keto is not achieved in somewhere around 99% of the people claiming to be keto dieting.

  26. Re:Don't like the science? Wait a few years by Anonymous Coward · · Score: 0

    Everybody fasts for periods every day. And you have to go without food for a surprising amount of time before there are any health problems that come from it. Several weeks or more is well within the realm of possibility if you're overweight to begin with.

    I'm not sure where people get the idea that you can't fast every day, because we literally have this term "breakfast" and we tend to eat it every day. Meaning that at some point during every day, we had a period of fasting. Most of that happens when we're asleep. But, we do fast every day.

  27. This is like the local news weather guy by edi_guy · · Score: 1

    "Therefore, optimal fasting in a timed manner would be strategic to positively affect cellular functions and ultimately benefiting health and protecting against aging-associated diseases."

    Why keep us in suspense? What is the freaking optimal fasting and timing? Tell us already. Just like the local news people. "There is a killer tornado bearing down on you, we'll tell you how to survive at 11."

    I assume, like many a mouse study, that there is a giant gulf between the results one gets with experiments on Mickey versus a real, live, 200lb human person.

    1. Re:This is like the local news weather guy by Gilgaron · · Score: 1

      Suspense? Why would they know that yet? They've just barely confirmed there appears to be more than just a correlative affect.

  28. Re:Na.. U shut up :P by wolfheart111 · · Score: 1

    Nana...

    --
    [($)]
  29. Re:prove me wrong by Cobratek · · Score: 1

    my statement is meant as more of a "don't do what I did without doing your own research" and less a demand for others to refute it.

    english, not my best subject but whatever

    --
    DONT TREAD ON ME MOÎΩN ÎABÃ
  30. Re: Look for the agenda by Anonymous Coward · · Score: 2, Informative

    Going in ketosis is not that hard. Sub 20 grams carbs/day is enough for most people.
     
    When I was going keto last year, I had my Ketones checked at work (im a hospital microbiologist), I was in ketosis within a couple weeks.

  31. Re:Don't like the science? Wait a few years by jma05 · · Score: 5, Interesting

    The fasting traditions in religion didn't make health claims.
    Fasting causes acidosis, which leads to mild euphoria.
    People also fast to promote the odds of transcendental experiences.
    It was an act of discipline.

    But no religion had the liver, let alone circadian clocks in mind.
    I wouldn't say religion *knew* fasting. It used it for an entirely different purpose.

  32. Re:Don't like the science? Wait a few years by Anonymous Coward · · Score: 0

    Shut up Dwight.

  33. Just stop it by Anonymous Coward · · Score: 0

    "This study opens new avenues of investigation that could ultimately lead to the development of nutritional strategies to improve health in humans."

    Stop eating, you fat fuck.

  34. Don't knock it until you've tried it... by Anonymous Coward · · Score: 1

    I'm amazed at how much snark is offered about intermittent fasting by those who rarely miss a single meal.

    Of course anything I say can only be taken as an anecdote, and naturally YMMV, but I've found it to be remarkably beneficial, and I'm glad there is increasing scientific inquiry into the particulars.

    My custom, these days, is to partake only of liquids (water and 2 cups of coffee - one with a teaspoon of sugar) on Wednesday and Saturday. Generally this results in two 36 hour intervals each week without food. The remainder of the week, I eat whatever I please, as much as I please. Been doing this for the past three years.

    Yes, you get hungry. Yes, your energy level drops. Yes, you get cold. OTOH, your mind clears, you have two days and nights free from any hint of indigestion, and you do reach a point somewhere around 26 hours where your hunger disappears. It is sometimes necessary to force myself to stop fasting.

    Before undertaking this regimen, I had chronic high blood pressure and elevated cholesterol levels, was 10-30 lbs overweight and survived several heart attacks and a bout with lung cancer. Now all blood levels and pressures are normal; I am a couple lbs under my "ideal weight"; and I am off all medications, leading a reasonably active lifestyle for one 64 years old.

    It is a tough regimen to start. I initially struggled to do one day a week - and failed to get through a full day many times. However, once you become accustomed to the new sensations you naturally encounter, and once you recognize that you will not die from these feelings, it gets considerably easier. Over time, as the benefits begin to appear, it becomes a regimen you are loath to abandon.

    Of course, I am fortunate that I am forced to choose this lifestyle, rather than having it forced upon me by want.

    1. Re:Don't knock it until you've tried it... by Anonymous Coward · · Score: 0

      I've been doing time-restricted fasting (skipping breakfast and not eating after dinner) for a couple of years now and it works for me. I tend to slowly loose weight when I stick to it and gain when I don't (christmas). I don't loose weight very quickly since it isn't a very extreme "diet" but I do loose weight steadily meaning my energy balance is about right.

      The main benefit is that it is effortless for me with no social or physical drawbacks. I don't get angry or tired when skipping a meal and I've noticed any cold hands can be countered with exercise. I can also participate in dinners and lunches like anyone else.

      I would recommend trying it to anyone who doesn't get lots of negative side effects from skipping meals (irritability etc).

  35. Re:Don't like the science? Wait a few years by zieroh · · Score: 3, Insightful

    That doesn't make it any more correct or relevant.

    The quote is correct, in that it is a faithful representation of the line spoken in the movie. And that quote was far more relevant to the conversation than your pathetic protestation.

    --
    People who say "sheeple" have about as much sophistication as an AOL user, and in fact are probably actually AOL users.
  36. Re: Don't like the science? Wait a few years by zieroh · · Score: 1

    Not at all impossible.

    --
    People who say "sheeple" have about as much sophistication as an AOL user, and in fact are probably actually AOL users.
  37. Or It Could Kill You! by Anonymous Coward · · Score: 0

    Ask Karen Carpenter. Oh right, she dead. O' course, the flip side, don't fast and become a stark raving madman. Ask Donald Trump. Oh right, he not dead.

  38. 2019: Still believing 'one size fits all' 'diets' by Rick+Schumann · · Score: 1

    Oh, please, people, stop, you're killing me..

  39. Re:Don't like the science? Wait a few years by Kokuyo · · Score: 4, Insightful

    Today people still believe that people 500 years ago believed the world to be flat.

  40. Re:Look for the agenda by Anonymous Coward · · Score: 1

    "Who now in the world likes fasting. Vegans, Mohammedans, and other religious cults."

    Indeed. Jesus was famous for it. Did it for 40 days.

  41. Re:Don't like the science? Wait a few years by Anonymous Coward · · Score: 1

    "The old religions have known about fasting for millennia. Science is way behind."

    Poor people have always been fasting for millennia, even thought they were illiterate and not religious.

  42. Re:Don't like the science? Wait a few years by x0ra · · Score: 2

    or you can assume that our body evolved mechanism to deal with the recurring lack of food and periods of fast might be where you are the sharpest. This would definitively be required to be able to find food. To the opposite, the constant influx of food is not "natural" to the body.

  43. Re:Don't like the science? Wait a few years by x0ra · · Score: 0

    or as I mentioned previously, "religions" are just archetypes of human biology pattern, and science is struggling to re-discover what has been known for millennia.

  44. Re: Don't like the science? Wait a few years by x0ra · · Score: 5, Insightful

    by definition, it *is*, as "breakfast" is litterally the "breaking of the period of fast" :-/

  45. Re:Don't like the science? Wait a few years by Anonymous Coward · · Score: 0

    "The quote is correct, in that it is a faithful representation of the line spoken in the movie. And that quote was far more relevant to the conversation than your pathetic protestation."

    BTW.
    You keep using that word, I don't think it means what you think it means.

  46. Re:Don't like the science? Wait a few years by x0ra · · Score: 1

    define "normal eating schedule" ? Last time I checked it was more "socially imposed eating schedule", nothing "normal" about it.

  47. Re:Don't like the science? Wait a few years by Chicken_Kickers · · Score: 1

    The 'breakfast is the most important meal" was a marketing propaganda by breakfast cereal companies. Stuffing yourself in the morning with high carb cereals leads to obesity especially kids who eat sweetened cereals. Eat when you are hungry and in moderation. There is no need to religiously eat at certain times of day. This is an artifact of the Industrial Revolution where you only had time to eat before work and during the official lunchtime. Cut out the high carb foods and sugary drinks and you'll find it is easier to control your diet. Eat more protein and fats so that you'll feel satiated longer.

  48. Re:Don't like the science? Wait a few years by angel'o'sphere · · Score: 1

    Haha,
    that is funny, insightful and awesome!

    --
    Cost free eBook I read (by iBook/Kobo/Amazon/ObookO/Gutenberg etc.): "The Green Odyssey" by Philip Jose Farmer.
  49. Re:Look for the agenda by angel'o'sphere · · Score: 3, Informative

    Potatoes are not that bad.
    McDonalds style french fries are, especially if you top them with ketchup and majonaise (hint: look up how french fries are supposed to look).
    The real problem is pasta from simple flour, white bread, the typical US processed rice, corn syrup in stuff where it simply does not belong, pizza with to much of everything. The "oversize" attitude. Artificial sweeteners in your drinks that completely mess up the digesting system.

    --
    Cost free eBook I read (by iBook/Kobo/Amazon/ObookO/Gutenberg etc.): "The Green Odyssey" by Philip Jose Farmer.
  50. Why didn't they use human subjects? by Anonymous Coward · · Score: 0

    Mice aren't humans, in case these fraudsters didn't know.
    There is no need to do animal experiments in cases like this, this is ridiculous. There must be millions of people who regularly fast, who would be willing to have tests done on them, to see if their fasting was beneficial.

    1. Re:Why didn't they use human subjects? by Anonymous Coward · · Score: 0

      They tried to get humans.

      Unfortunately, all they found were skinny ones.

      Yes, let's waste a few trillion more studying how to maintain a properly functioning body. Obviously it's still a mystery. You know, like the concept of regular exercise is for most people...

  51. Re:fasting by rotovator · · Score: 0

    Me too. For a moment I thought I was surfing elsewhere

  52. Re:2019: Still believing 'one size fits all' 'diet by Anonymous Coward · · Score: 0

    'one size fits all' 'diets'

    Since the 1990s, there's been increasing effort to study human metabolism in-situ and compare it to the 'standard model', causing a plethora of purpose-built diets. This report isn't so much a diet as recognizing that a one-off dietary event can be beneficial.

    ... opens new avenues of investigation ...

    The report could be linked to the 5/2 diet (5 days, full meals; 2 days, fasting), but it didn't promote a known diet.

  53. Re:Don't like the science? Wait a few years by jma05 · · Score: 5, Insightful

    Most of what had been "known" for millennia was wrong. That is the whole point of doing science.
    But even a broken clock can be right twice a day.
    The scientific process for doing dietary studies though is less than stellar today. But that can be fixed.
    Science is working, not "struggling". Never before in human history has so much been uncovered in such a short time.

    > "religions" are just archetypes of human biology pattern

    If so, we would not have so many religions. Religions occasionally are codifications of natural human behavior - social, more than biological. Other times, they deny natural human behavior.

  54. Is this Pseudoscience: "Could" becomes "Is" ! by Anonymous Coward · · Score: 0

    "The reorganization of gene regulation by fasting *COULD* prime the genome to a more permissive state to anticipate upcoming food intake and thereby drive a new rhythmic cycle of gene expression. In other words, fasting *IS* able to essentially reprogram a variety of cellular responses.

    They convert their speculation into a fact in the space of one sentence.

    Is this psychology-style pseudoscience ?!

  55. Re:Look for the agenda by houghi · · Score: 3, Informative

    I live in Belgium, we know not only how fries supposed to look, but also that double frying is the answer to soggy fries. And you are supposed to eat them like this

    I think I just gained a kilo just looking at those images.

    --
    Don't fight for your country, if your country does not fight for you.
  56. Re:Don't like the science? Wait a few years by jma05 · · Score: 2

    Asserting health benefits with no data is cheap, even when occasionally correct. Showing with data and analysis is actually knowing (science).
    There is still quite a bit that needs to be investigated with regards to diet. The basics are well understood. The long term effects are less well understood since that research is harder (to control).

    > You seem not to belong to the "western world" anymore with your retarded science.

    The only "retarded" arguments seem to be yours. What western world? I have not cared to divide the world into East and West here.
    What makes you think I am from the "western world" in the first place? I don't remember declaring my location. Where I am from/at, religious fasting for the public usually simply means eating lightly for dinner, abstaining from the main staple diet, not complete caloric abstinence, which is left to monks.
    In the data-centric modern world we collectively inhabit today, east and west is irrelevant. One measures. One verifies. Biological realities have little need for philosophies and theologies.

    > in most religions fasting was done during periods were they had no food anyway.
    > were fasting was artificially introduced, because they simply copied it from Christians.
    > But they were smarter, as they had irrigation and food: they were allowed to eat after sunset. Hence: Ramadan is actually a big party.

    What does all that have to do with my statement that religious fasting has little to do with health? Culturally, the point was an offering or sacrifice, that you cared about it enough to endure some discomfort and participated in a collective activity which perhaps contributed to some degree of social cohesion.

  57. Re:Don't like the science? Wait a few years by mobby_6kl · · Score: 1

    Science can be a liar, sometimes!

  58. Re:Don't like the science? Wait a few years by Shaitan · · Score: 2

    It is a well known pop culture reference which pertains the the concept underlying his statement. It was correctly quoted and it is certainly relevant. If he links an article containing a spelling error are you going to correct hat as well? It was the correction which wasn't relevant, his argument wasn't based on that detail.

  59. Re:Don't like the science? Wait a few years by Anonymous Coward · · Score: 0

    > To the opposite, the constant influx of food is not "natural" YET to the body.

    Fixed that for you. You can't have it both ways.

  60. Re: Don't like the science? Wait a few years by Anonymous Coward · · Score: 0

    This is your myth about myths, basically a dishonest lie to yourself. Nobody's buying it.

  61. Re: Don't like the science? Wait a few years by Anonymous Coward · · Score: 0

    That's not fasting. Fasting is eating nothing for a couple of days, even avoiding some types of juices, doing no work, drinking more water. You'll start noticing after 24 hours. Can be combined with intestinal cleanse.

    This may reboot gut and bowel, and research show health benefits.

    But of course people can come up with whatever, call it what they like and justify it all. But it's not the same.

  62. Re:Don't like the science? Wait a few years by Deaddy · · Score: 0

    Actually most of the alleged health benefits of fasting have not been confirmed to a point where they are physiologically significant. You often get some markers to improve in a statistical significant way, but that does not yet tell you if it is actually better, as the human body functions in a wide range of many parameters. Maybe with exception of acidity, which people still do not understand and I just yesterday saw a real life ad for some alkaline diet supplement.

    On the other hand, we have evidence for the utility of breakfast or regular eating, my favorite example being that food intake after waking can help to shift the circardian rhythm into waking up earlier, because you anticipate food at that time.

    My guess is that in the end we will find that different feeding schemes (fasting, intermittent fasting, regular eating) always make slight tradeoffs. It is to be expected that it turns out similar to the vegetarian/meat eating diet, i.e. the same all cause mortality, but just a shift in the causes.

    By current evidence (and as stated, I do not expect this to change) it boils down to the right tool for the right job. For some populations such as manual laborers or heavy athletes (strongmen, bodybuilders, hammer throwers, what have you) a time restriction on food intake may make it very difficult to meet caloric goals. On the other hand, if you are sedentary and only need something around 2Mcal a day, have a bad habit of snacking, are already fat or just don't like to prepare food, eating only in a certain time window (or even once a day) may be the thing to do.

    Finally, do not trust anyone who talks to you about autophagy.

  63. I just hope... by Parker+Lewis · · Score: 1

    I hope all these studies are not tied to religions that preach fasting.

  64. Self-discipline is still a scarce resource by Anonymous Coward · · Score: 0

    For many First World people, health improvements by a reduction of calory intake would be blindingly obvious low-hanging fruit. Sweetening the deal is not going to make a change.

  65. Re:Don't like the science? Wait a few years by Anonymous Coward · · Score: 0

    Maybe you are right, maybe not. I have no clue how these things work. I tried one day a week fasting some time ago. I planned to measure my sugar levels to see how that works long term. I skipped on that because suddenly I felt great. I have not lost weight but I felt invigorated and my depression seems to have gone away too in big part. My life is still shit (thanx to few decisions I made along a way) but I feel much much better. I also started eating meat again. Not as much as I used before my health problems started but good steak or sausage I do enjoy. Except this one day in a week. Maybe it is not related to my day of fasting but unless somebody tells me this is going to destroy my life and I will burn in hell for it too I am not going to stop now.

  66. Re:Look for the agenda by Anonymous Coward · · Score: 0, Flamebait

    LOL "french fries".

    They are called chips, you illiterate, uncultured fuck.

  67. Re: Look for the agenda by aliquis · · Score: 1

    I like the last point.
    Yeah artificial sweeteners are the problem ... As if. Except the obvious in that you get used to a more sweet taste and it doesn't feed you so you still want food and maybe prefer a sweeter one.

  68. Re: Don't like the science? Wait a few years by aliquis · · Score: 1

    Not behind.
    Just scientific.

  69. Re:Don't like the science? Wait a few years by Anonymous Coward · · Score: 0

    Religions promote fasting for spiritual reasons.

    Can you provide citations for religions promoting fasting for reasons of health?

    You can't say religions know something, if there are no specific claims made by the religion regarding it.

    Meanwhile, science all the time discovers things that religion either knew nothing about or made incorrect claims about.

  70. Re:Don't like the science? Wait a few years by Luckyo · · Score: 0

    "Much", and a tiny, tiny portion was wrong. Overwhelming majority was right.

    Citation: religious societies survived the evolutionary selection process. Non-religious did not.

  71. I just hope..religion can't be correct at anything by Anonymous Coward · · Score: 0

    What? People just don't want to admit that religion just may teach them a thing or two.

  72. Re:Don't like the science? Wait a few years by rednip · · Score: 1

    The idea that 'everyone thought that the earth was flat 500 years ago' is a myth. The ancient greeks knew that that the world is roughly round; Pythagoras wrote as much in 600 BC. Christopher Columbus was ridiculed because he believed that the world was half the size that most who had studied the subject believed. They were right, if he hadn't run into 'the west indies' rather than India as he planned, the famous explorer would be nothing more than a footnote at best. https://www.washingtonpost.com...

    --
    The force that blew the Big Bang continues to accelerate.
  73. Side effects by Anonymous Coward · · Score: 0

    While I believe the study may be on to something with the benefits of fasting, I'd like to point out other studies have shown drawbacks to fasting, particularly in the young or pregnant. Fasting has been linked to all sorts of disorders, especially in the earlier stages in life. Its benefits may be outweighed by the side effects.

  74. toke by Anonymous Coward · · Score: 0

    Pot makes you anticipate eating too, so I guess that's one of its benefits.

  75. Re:Don't like the science? Wait a few years by thegarbz · · Score: 0

    20 years ago it was "skipping breakfast" and was bad for you.

    One thing has remained constant over time, and that's people's ability to generalise highly specific studies and then draw conclusions that science doesn't know what it's doing.

    Guess what: Skipping breakfast is still bad for you. Intermittent fasting is still good for you. Your problem was that you never defined "bad" or "good" and therefore you think these conclusions are somehow opposed to each other and inconsistent. They aren't.

  76. Fasting protocols by Anonymous Coward · · Score: 0

    Most studies are showing rather significant positive impacts from fasting periods due to specific metabolic and restorative/recycling pathways that are otherwise not activated except during low calorie states which were probably typical for all animals throughout history. Our current unnatural exposure to constant food and eating seems to be a very artificial form of living that we are not adapted to and we should, for the most part, take advantage of the metabolic/healing processes associated with low calorie intake.

    Until research shows otherwise I would recommend periodic fasting to almost everyone.

  77. Re:Look for the agenda by Anonymous Coward · · Score: 0

    As a Belgian, I have to say that mitraillette (fries in bread) is an aberration and this is exactly how fries should not look: disgusting. The traditional way is a "cornet" which is literally a folded sheet of paper (historically, a newspaper - the poor were the one selling fries in the streets).

  78. No Kidding by Anonymous Coward · · Score: 0

    I can't believe all these new "discoveries" that tell us "human bodies work best when they work the way they evolved to work over millions of years."

    Up until very recently, and by recently I mean just a few thousand years ago (which is a microsecond on the evolutionary timescale), it was routine for man to eat only once every couple or few days. So naturally, the body evolved to be its strongest under these conditions.

    I started a paleo diet 10 years ago, eating what humans ate 10,000 years ago, and eating it as often as they ate it, only three or four days a week. At my one-year checkup after starting to eat this way, I had lost 110 lbs, my blood pressure fell over 100/40 points, my cholesterol halved, and my diabetes completely went away. I went from sleeping 10-12 hours a day to sleeping about 6 hours a night, and my energy levels went through the roof.

    The moral of this story: EAT THE WAY YOU'RE DESIGNED TO EAT.

  79. Re:Look for the agenda by Anonymous Coward · · Score: 0

    You doing it wrong.
    How about just keeping under 100grams of carbs and stop the insulin spikes. The SAD is up to 300, 400, 500 grams of carbs, insane, and deplorable, considering this was foisted upon the people by lies from state actors.

  80. Re:Don't like the science? Wait a few years by Anonymous Coward · · Score: 0

    Citation: religious societies survived the evolutionary selection process. Non-religious did not.

    Yep, because the religious ones murdered all of the non-religious ones! Funny how that worked innit?

  81. Re:Don't like the science? Wait a few years by skam240 · · Score: 1

    Following that logic, everything we know is false because it could be falsified some day.

    That's stupid. You work with the best data you have available to you.

    --
    I ignore Anonymous Coward posts. If you want to discuss something, that's awesome. Log in.
  82. Re:Don't like the science? Wait a few years by doubledown00 · · Score: 1

    The point of the comment was changes in consensus over time. But since you wish to be a Slashdot neckbeard and pontificate over commonly understood colloquial terms rather than discuss the issue, here is an MD saying the same shit I did:
    https://health.usnews.com/heal...

  83. Re:2019: Still believing 'one size fits all' 'diet by Anonymous Coward · · Score: 0

    There is no reason to believe this 'one off' 'dietary event' will work as advertised for everyone, but everyone who is fat and desperate will now try it anyway then cry and whine when it doesn't work, or worse: they'll keep doing it to the point of Emergency Room. Call it evolution in action?

  84. Re:Intermittent Fasting Is Not a Miracle Weight Lo by ath1901 · · Score: 1

    That article does not counter the claims of this study. Most of the claims are also dubious.

    "There's not much research". No, but there isn't much research on keto, paleo, or most other diets. The reason is that human long term trials are difficult to get right and expensive. There is a reason most diets are hyped at first as being "special" but when science catches up they turn out to be no better than a similarly calorie restricted diet.

    "It's hard to do". Depends on the regimen and your body. Time-restricted fasting is much easier than intermittent (or longer) in my experience. But, I suspect this differs a lot from person to person.

    "It can be unhealthy!" ... for people with who have a history of eating disorders... Yeah, that was really dumb.

    "Other forms of calorie restriction are more effective". Misleading, it depends. If you find fasting easy, you can go for a more extreme regimen and thus make it more effective. Effectiveness is really based on how difficult you find a particular type of diet. If counting calories is hard for you, then fasting might be easier or vice versa.

  85. Re:Don't like the science? Wait a few years by Anonymous Coward · · Score: 0

    I'm not sure I get it. Since you only eat when you are hungry you are always eating and you just died from some obesity-related disease, is that the joke?

  86. Re:Don't like the science? Wait a few years by DontBeAMoran · · Score: 1

    The joke is that if that was the new fad, you'd still find morans who can't even listen to their own bodies and would starve themselves anyway.

    --
    #DeleteFacebook
  87. Re:Don't like the science? Wait a few years by jma05 · · Score: 1

    > "Much", and a tiny, tiny portion was wrong

    Not true. MOST of what was claimed from religious frameworks was wrong.

    It is quite uncommon for old religious claims to be held up by science. It is just that it makes news when it rarely does.

    This is also obvious if you give it even a minute of thought. Since Truth is singular, all religions must then make identical claims. But they do not.

    This is however true of Science. There are no multiple versions of Physics or Chemistry, but you can have an infinite variations on religion.

    > Citation: religious societies survived the evolutionary selection process. Non-religious did not.

    They survived on social and cultural grounds, not ontological grounds. Survival fitness requires very little Truth. Humans aside, least complicated creatures survive better than more complex, not the ones that "know" most.

    It is generally reproductive fitness, not intelligence that contributes more to survival. Religions with an active or aggressive propagation component survive better than "more true" or at least less false religions. The job of the priest/theologian/apologist is partly to deny deviance from known reality and that the texts were never wrong, even against overwhelming evidence.

    Create a sophisticated philosophical religion with no proselytization element and it has no chance against an emotional one that appeals to convert as many as you can to its fold through power (wealth or violence).

  88. Re:Don't like the science? Wait a few years by segedunum · · Score: 1

    True. Even though there was evidence as to the true nature of the Earth the belief was still widespread that it was flat, It took a long time to change.

  89. Re:Don't like the science? Wait a few years by segedunum · · Score: 1

    Yes it does.

  90. 36 hour fasts weekly by Anonymous Coward · · Score: 0

    I did weekly 36 hour fasts (eat dinner normally Monday, Tuesday green tea and water only, bo to be hungry, eat breakfast Wednesday morning).
    Lost 30 pounds in 3.5 years. But in the last year, began to feel weak. Of that 30 pounds, 10-15 pounds were muscle. Blood tests showed too much muscle breakdown (elevated BUN).

    So, took a few weeks break, and converted to once a week 24 hour fasts (skip breakfast and lunch). Added back some carbs. Gained 10 lbs back and feel great.

    Moral, don't push too far, work with your doctor (blood tests), and moderate if you start feeling weak. My mistake was not high enough protein after the fasts and not enough weight lifting/exercise to stimulate muscle maintenance.

  91. Re:Don't like the science? Wait a few years by Anonymous Coward · · Score: 0

    But even a broken clock can be right twice a day.

    Just came here to post this Withnail and I
    Great movie!

  92. Re: Look for the agenda by illiac_1962 · · Score: 1

    Bad advice. Excessive protien brings disease. But hey, you can drop a few pounds scarfing down steak instead of baguettes.

  93. Re: Don't like the science? Wait a few years by illiac_1962 · · Score: 1

    We are done evolving unconsciously.

  94. Re: Don't like the science? Wait a few years by illiac_1962 · · Score: 1

    Most of the religious laws were concerned with promoting health and stable society. The smart people used the scary God dude to keep the dunces in line.

  95. Re: Don't like the science? Wait a few years by illiac_1962 · · Score: 1

    We are just now resolving the basics. Not even done yet. Government authority infused "scientists" had it dead fucking wrong for several generations and the wrong shit is still on the books.

  96. Re: Don't like the science? Wait a few years by jma05 · · Score: 1

    By that you mean the carbohydrate based food pyramid that was driven by farm lobbies and not sound science. I get that.

    That not withstanding, the basics are still considered resolved some 50 years ago. The basic biochemistry here has not changed radically.

  97. Re:Don't like the science? Wait a few years by js290 · · Score: 1
    --
    "Tempers are wearing thin. Let's just hope some robot doesn't kill everybody." --Bender
  98. Re:Don't like the science? Wait a few years by js290 · · Score: 1

    The fasting traditions in religion didn't make health claims.

    In this regard, religion 1, science 0.

    --
    "Tempers are wearing thin. Let's just hope some robot doesn't kill everybody." --Bender
  99. Re:Don't like the science? Wait a few years by epine · · Score: 2

    The old religions have known about fasting for millennia. Science is way behind.

    Great, if you had a handy decoder ring to help separate the few things they got right from all the other batshit they didn't.

    The modern definition of "known about" means that you have substantive evidence where you don't need to resort to a telepathic-genie powered decoder ring.

    We know that Einstein's correction to Newton improves on Newton's original predictions of celestial motions. This will never change. We might come up with yet a better prediction than Einstein's, but nothing we could feasibly learn will cause Newton's old predictions to suddenly regain the lead.

    The substantive import of "known about" has improved just a smidgen over the past 3000 years.

    Nearly a Billion People Still Defecate Outdoors. Here's Why. — August 2017 CE

    No, I did not drop the B from BCE, or write "billion" when I meant "million".

  100. Re: Don't like the science? Wait a few years by epine · · Score: 1

    The basic biochemistry here has not changed radically.

    Depends on what you mean by the word "basic".

    Old-fashioned: underlying reactions.

    New-fangled: underlying reactions, plus the metabolic control regime.

    Old-fashioned: Micro what?

    New-fangled: Microbiota.

    Old-fashioned: Epi what?

    New-fangled: Epigenetic.

    But I get your point: the basics of solar navigation haven't really changed much since the trusty slide rule.

  101. Re:Look for the agenda by Daralantan · · Score: 2

    Potatoes are not that bad. McDonalds style french fries are, especially if you top them with ketchup and majonaise

    It all comes down to your goals and what you're doing. Also genetics somewhat as well. Some people do great with low carb and ketosis. Some people it's almost dangerous for.

    If you want to do endurance sports or focus on fat burning ketosis can be a good thing for you. If you're more of a sprinter, power lifter, or strength based athlete carbs may serve you a bit better as you would do best with quick energy you have immediate access to. Not to mention carbs are one of the easier ways to putting on weight (needed for muscle). Generally ketosis is better for endurance sports and fat burn focus.... with carbs being better suited to strength and explosiveness. Right now I've finished with my recent races and wanted to focus on strength so I'm enjoying eating a bit more reckless.... but I'm also lifting super heavy in the gym.

  102. Re:Look for the agenda by houghi · · Score: 1

    Shhh. I do it to confuse the American tourist. I also tell them Duvel is a light pils as it tastes a bit sweet and the best chocolates are Leonidas. That is why there are stores everywhere.

    The real fun is having them drink a few light Duvels and start explaining the Political and language situation. Be sure to be in a pub with late or no closing hours and even better if it is a 18 or 19 year old without any real drinking experience who thinks he is the man. (Only if they think that, others are really nice and will be treated accordingly. And yes, it is alway men.)

    --
    Don't fight for your country, if your country does not fight for you.
  103. Re: Don't like the science? Wait a few years by Anonymous Coward · · Score: 1

    It doesn't have to end at either eating or starving. There are several other ways of dying.

  104. Re:Don't like the science? Wait a few years by thegarbz · · Score: 1

    But since you wish to be a Slashdot neckbeard and pontificate over commonly understood colloquial terms

    No. There was no "consensus". Pointing out that that commonly "understood" terms are completely misunderstood and not backed by any science is not being some pontificating neckbeard, it's there for the betterment of society.

    The MD highlights your comment just as much as it highlights my point: "The most important meal of the day" had no influence and was never backed by science which brings me back to my conclusion, which I will now re-quote for prosperity:
    Guess what: Skipping breakfast is still bad for you. Intermittent fasting is still good for you. Your problem was that you never defined "bad" or "good"

    As soon as anyone uses the word "bad" or "good" to defined something as complicated as nutrition you have lost. If I am a neckbeard pontificating then let me pontificate this to you: BE BETTER. Don't dumb down science into worthless words only to reiterate the notion that our knowledge is changing. It is not.

  105. Re:Look for the agenda by Anonymous Coward · · Score: 1

    Long time member here, also happen to be Muslim. But I am posting anonymously because of the blatant bias many members show here, including down mods, trolling, name calling ...etc.

    Muslims don't know the first thing about fasting, Ramadan is a joke: not even water during daytime, only to eat triple the normal daily amount all night long is NOT intermittent fasting, it's binge eating with a cooldown phase.

    Yes, Muslim fasting means no eating, no drinking and no sex from first light till sundown. That is usually around 15 to 17 hours, depending on length of day (summer vs winter, latitude).

    As for eating triple, that is not what fasting is about at all. It is quite the opposite.

    Indeed, many people do binge, but that is only in recent times where most people have access to plenty of food. Another factor is the custom of inviting people over for breakfast (at sunset), and in most Muslim cultures, that involves being extra generous with many dishes and portions. So some do it like American Thanksgiving or Christmas.

    But traditionally, Ramadan was not about overeating. Quite the opposite. It was about moderation and remembering those who are hungry not by choice, but of not having enough food. It was also about curbing one's desires, and strengthening self control.

    Muslim fasting is not the only type of fasting. In the Middle East, there are Christians who fast too, but in different ways: some abstain from animal food (go vegan, before the term was invented). That includes no meat (obviously), as well as no milk, butter, cheese, nor eggs. And the observant ones do it for as long as 200 days a year, not just 29 or 30 like the Muslims.

    Hindus and Buddhists have their fasts too.

    There is no general rule for all the above, except restriction of diet (type and/or quantity) for some time.

  106. Re:prove me wrong by epine · · Score: 1

    Yes he is. His claim is total bullcrap.

    You don't understand weight.

    It's the force of gravity toward the gravitational center of a large, solid body on the sum total of your person, conventionally including your hair, your giant curtains of skin (should you be unfortunate enough to have one), your circulatory system, your bladder, your colon, your lungs (and fluid accumulations), your sinuses (and fluid accumulations), etc.

    It's absolutely possible to lose 10 lbs in one week, without surgery to remove a balky limb or a giant skin flap, contracting hemorrhagic fever, or even just a flair-up of your severe hyperthyroidism.

    What's not possible is to reduce the fat component of your body composition by ten pounds in one week through regular metabolism, excepting the oddities above, and their next of kin.

  107. Re:Look for the agenda by schweini · · Score: 1

    McDonalds fries are famously also double fried at exactly the 'correct' temperatures.
    Serious Eats reverse engineering of McDonalds fries

  108. Re:Don't like the science? Wait a few years by The+Grim+Reefer · · Score: 1

    "1,500 years ago, everybody knew that the Earth was the center of the universe. 500 years ago, everybody knew that the Earth was flat. And 15 minutes ago, you knew that humans were alone on this planet. Imagine what you'll know tomorrow."

    Sorry Agent K, you got that backwards. Pythagoras postulated the earth was round by 500 BC, mostly because he thought spheres were really cool. Aristotle used observational evidence for it being round in mid 300 BC. In mid 200 BC Eratosthenes estimated the earth to be 250,000 stadia. We don't know exact size of a stadia, but it's estimated to be between 500 and 600 feet. So his estimate of the circumference of the earth was between 23.6 thousand and 28.5 thousand miles.

    The geocentric model was widely used until the 1500's AD.

  109. Re:prove me wrong by crtreece · · Score: 2

    You don't lose 10 lbs in one week even if you eat ZERO food. Losing a pound of fat requires a calorie deficit of 3500 calories. An adult male has a breakeven point of about 2000 calories per day. So the most you are going to lose in one week of ZERO food is about 4 pounds.

    You aren't accounting for lost water weight. At the start of caloric restriction, it's pretty common to have a sharp drop as the body gets rid of the extra water it carries around to help process all the extra calories that were being consumed previously.

    Obs. this isn't sustainable long term, and it can be frustrating for someone that sees a quick drop when they start caloric restriction, and then their weight loss trend levels out after their water loss stops.

    --
    file: .signature not found
  110. Re:Don't like the science? Wait a few years by js290 · · Score: 1

    >

    Great, if you had a handy decoder ring to help separate the few things they got right from all the other batshit they didn't.

    Sounds like you're committing base rate fallacy. For most people, you have to also consider what did religion got right. Scientism has its own decoder rings...

    "the absence of religion... replaced by all kinds of crazy beliefs... you realize there's no religious fundamentalism that's more irrational than an atheists' primitive use of probability" http://bit.ly/2Hi4pNK

    Survival comes first, truth, understanding, and science later... In other words, you do not need science to survive (we’ve done it for several hundred million years) , but you need to survive to do science. https://medium.com/incerto/how...

    --
    "Tempers are wearing thin. Let's just hope some robot doesn't kill everybody." --Bender
  111. By definition, it IS impossible by Anonymous Coward · · Score: 0

    Then by definition, every meal is breakfast. You fast between meals, and then break the fast by eating again.

    Therefore, skipping breakfast is impossible, unless you stop eating until you starve to death.

  112. Re:Don't like the science? Wait a few years by Anonymous Coward · · Score: 0

    TIL mackerel sushi isn't good.. it tastes bad and it doesn't sit well with me.

    So, yes we are learning new stuff daily!

  113. Re: Don't like the science? Wait a few years by js290 · · Score: 1

    And the best nutritionist is your great-grandmother. https://t.co/43GMbh6fLt

    — Nassim Nicholas Taleb (@nntaleb) January 9, 2018

    --
    "Tempers are wearing thin. Let's just hope some robot doesn't kill everybody." --Bender
  114. Re:Don't like the science? Wait a few years by Anonymous Coward · · Score: 0

    Interesting. Science requires faith before reason can be found. You seem to be forgetting that there is not much difference in the beginning of a science(see psychology) between religion and science. The faith inherent in the average psychologists belief that what is in the DSM is the gospel truth(it is afterall a religious text as in general a practitioner who argues against its' content is seen as a heretic or blasphemer).

    If you would like examples please see the entire history of psychology and the lives it has ruined because of mistaken beliefs which were put forth as scientific fact.

    While the hard sciences are in general more accurate they can also be faith based. see SUSY(. Your rant above is short sighted and frankly shows that you, yourself, are nothing but a zealot for the religion of science.

    p.s. Science has its' place and our modern world would not exist without it. That said, however be careful to distinguish scientific method and "Science". Treating scientists as a whole as some reveared beacon of truth moves them into the realm of a priesthood and destroys the point of doing science. Not all science is good. Not every accepted natural law is correct. Just because we "Know" something does not make that something correct. If you were honest with yourself you would realize just how little we know.

  115. Re: Don't like the science? Wait a few years by fatwilbur · · Score: 1

    I was always the prototypical "skinny nerd" through my late teens and twenties. Once I hit 30, I wanted to bulk up a bit, not become a muscle head but at least look a bit better physically. While it might just be me, I struggled to put on weight by exercising and eating more heavily (and trust me, eating 3000+ calories per day when you're not used to it is HARD).

    Most interestingly is that I'd always been a no-breakfast type of person, just wasn't hungry until around lunch. Instead of massive calorie loading around dinner time, when I finally starting eating breakfast, weight started to stick like no tomorrow. I put on 25-30 lbs in just two months (mostly muscle). Not sure what this translates into, just an interesting anecdote as it was clearly breakfast which had the effect. Note that I am still unable to eat a good meal for breakfast, my body just isn't hungry and hard to eat food, so I down a meal replacement shake.

  116. Re:Don't like the science? Wait a few years by Luckyo · · Score: 1

    Outcompeting your competition takes many forms in evolution. That is one of those forms, yes.

    So?

  117. Re:Don't like the science? Wait a few years by Luckyo · · Score: 1

    This is largely correct, and one of my main worries when it comes to survival of scientific method as the primary method of generating new knowledge. Just a couple of decades ago when I was young, the biggest people who tried to push the idea that science is a religion were folks who argued against science.

    And now those who are arguing for science are arguing about it in religious terms. That spells death of scientific method, and we're already seeing religious movements masquerading as science within academic circles today.

  118. Re:Don't like the science? Wait a few years by Anonymous Coward · · Score: 0

    Don't confuse modern medicine with science.

  119. Re:Don't like the science? Wait a few years by cayenne8 · · Score: 1

    Only one way to find out... I started the "fad" a couple weeks ago, restricting my eating time to 8 hours a day and 16 hours of fasting with some 24+ hours fasts thrown in here and there. I'm less concerted about weight loss and more focused on cholesterol and an A1C that puts my blood glucose levels on the edge of pre-diabetic. I'm decently fit and athletic, healthy diet, middle of the "healthy weight" for my height and sex. I plan to fast this way every day for 3 months, though still keeping my typical diet, and get some bloodwork done to see if my numbers improve at all. It does seem effective for weight loss even though that's not my focus. It's a much easier plan to follow than calorie restriction, I just eat when I'm hungry during my 8 hour window... but I'm not as hungry after the first few days of the fasting which is causing me to run a slight calorie deficit. Interested to see if this has any positive or negative effect on my insulin resistance and cholesterol levels, I've had bloodwork done regularly for the past 8 years so I have a pretty good baseline.

    I've been trying the intermittent fasting like you described too.

    However, I pretty much blew it over the Xmas/NY holidays...and starting back on that. I've also gone back low carb.

    My blood is good except for triglycerides. My cardio Dr. said go low carb. I'm hoping to see if both intermittent and low carb (keto starting out) can get that last blood fat out of my numbers.

    --
    Light travels faster than sound. This is why some people appear bright until you hear them speak.........
  120. Re:Don't like the science? Wait a few years by Anonymous Coward · · Score: 0

    What about the M prophet grooming banging a kid?
    that's not normal.

    Fuck Mohammad I curse the shit stain he's left on this planet.
    May the people under his thumb know true freedom.

  121. Re: Don't like the science? Wait a few years by Anonymous Coward · · Score: 0

    We are done evolving unconsciously.

    Your subconscious mind might have something to say about that.

  122. Re:Don't like the science? Wait a few years by Pyramid · · Score: 1

    "Citation: religious societies survived the evolutionary selection process. Non-religious did not."

    A) That's not how citations work
    B) What is your evidence for this?

    --
    ~Any apparent grammatical or typographic errors are caused by defects in your display device.
  123. the real payload by epine · · Score: 1

    The real payload:

    We demonstrate that the transcriptional response to fasting operates through molecular mechanisms that are distinct from time-restricted feeding regimens.

    Note that while the genetic pathways may be distinct, this is not the same as saying that establishing a TRE practice (easy, if you start with a broad 12-hour restriction window) won't later help you adapt to an actual fasting practice.

    Nor does this state that the genetic response to TRE is less beneficial than the genetic response to actual fasting. It merely demonstrates that these are distinct metabolic regimes, with potentially different costs and benefits.

    Mostly I see this as a glass half full: if your metabolism is tilting toward metabolic syndrome on a standard American diet, there are now two distinct exits in the when rather than what camp, either of which might provide some relief.

    The "what" camp had a long run, and was mostly found wanting.

    Perversely, some people still belief in the greedy algorithm of weight reduction: winning the battle between calories in, calories out by any means available. The unstated presumption is that once you win this battle, the greedy algorithm turns to confront the next great personal challenge: dealing with perpetually feeling cold, listless, and unmotivated. Which is then easily solved by restoring the previous anabolic diet.

    (Greedy algorithms are notorious for going around in circles, if you're not lucky, or the problem set is not analytic.)

    TRE and fasting have the potential to improve your blood chemistry, without rendering you permanently cold, listless, and unmotivated.

    Jason Fung explains the now well-established model of caloric-restriction pick one:
            [ ] weight rebound
            [ ] long-term metabolic slowdown
    in his book The Obesity Code: Unlocking the Secrets of Weight Loss — 2015

    Not my favourite book of all time, but a credible, recent round-up from a Canadian nephrologist with expertise on intermittent fasting.

  124. Re:Don't like the science? Wait a few years by Luckyo · · Score: 1

    Observable reality.

  125. Re:Don't like the science? Wait a few years by Anonymous Coward · · Score: 0

    Are you literally autistic?

  126. Basically, it just tells your cells rebuild by WillAffleckUW · · Score: 0

    Caloric restriction causes your cells to go into a self-cleaning mode. A lot of stuff gets built up to handle the vagaries of life, and things that aren't working well are normally left alone. When the pathways respond to caloric restriction (NOT dieting, that is bad), they scavenge all the stuff they don't need right now.

    Basically, just drink broth and take vitamin pills (the normal kind), not "empty" calories, for around 10-14 days. Longer won't help.

    You also need to continue exercising at a normal level. This forces your fat reserves to send the signal indicating depeletion, and the exercise keeps everything running.

    I did this a few years ago, during the summer, when I tend not to get that hungry. Vegetarian broth, some miso, salads (skip the dressings), vitamins, lots and lots of iced tea with a dash of lemon juice. Got lots of exercise. It was fun! Hardest part was no bubble tea, no ice cream, other desserts. Berries, nuts and veggies were ok. Skip alcohol.

    --
    -- Tigger warning: This post may contain tiggers! --
  127. Re:Look for the agenda by MonteCarloMethod · · Score: 1

    Nonsense, this is what fries are supposed to look like: https://s3.amazonaws.com/cdnme...

  128. Re:Look for the agenda by laie_techie · · Score: 1

    LOL "french fries".

    They are called chips, you illiterate, uncultured fuck.

    The term "french fries" comes from the fact the potatoes are "french cut" (julienne cut) and then fried. As to "uncultured", that's just hogwash! Nearly everyone has a culture, even if it doesn't match your own.

  129. fasting made me fatter. by Anonymous Coward · · Score: 0

    Each time I did fasting, I ended eating more, after, and getting fatter, permanently. It also caused to me hallucinations.

  130. Re:Don't like the science? Wait a few years by x0ra · · Score: 1

    Survival is what matter, how they managed to is irrelevant.

  131. Re:Look for the agenda by laie_techie · · Score: 1

    I belong to the Church of Jesus Christ of Latter-day Saints. I, too, have noticed that many use caricatures when describing other religions and cultures. My Christian sect does not observe Lent, but we have our own fasting. On the first Sunday of the month healthy members fast either 2 meals or 24-hours (depends on personal interpretation) without food or water. This can be modified based on individual needs (eg. drink minimal water in some climates, or avoid low blood sugar for diabetics). We donate the money we would have spent on food to a "fast offering" fund which is used to provide for the poor and needy. We are strongly encouraged to be generous in this offering. No, the money doesn't go into the bank account of the bishop or other leaders. Members can also fast at other times based on their needs. We believe that by combining fasting with prayer we can increase our spirituality. We've been doing this since our sect was founded in 1830. It's good to see that there might be some health related benefits to our religious practices.

  132. Re:Don't like the science? Wait a few years by Anonymous Coward · · Score: 0

    Ive been skipping breakfast for about 20 years now, and I eat a fairly early dinner (6pm), so every day I fast for about 18 hours.

    Works for me. I'm 32 w/ a lean athletic build, no medication, and love "fattening" foods.

    Best part? Hunger really is the best spice.

  133. Re: Look for the agenda by Anonymous Coward · · Score: 0

    LOL. Mod +5 funny.

  134. Re: Don't like the science? Wait a few years by Anonymous Coward · · Score: 0

    No citations because religion and god are made up constructs.

  135. Paul Bragg - "The Miracle of Fasting". by Anonymous Coward · · Score: 0

    Paul Bragg - "The Miracle of Fasting".

    Changed my life.

  136. Re:Look for the agenda by Anonymous Coward · · Score: 0

    Do you also double fry your tulips? Are you allowed to wear your wooden shoes in the kitchen or is that a safety violation? What about your stupid hooplehead bonnet?

  137. Re:Look for the agenda by s4080326 · · Score: 1

    You don't need to double fry to avoid soggy fries, but you do need to double cook them. I've found microwaving the potatos using your microwaves baked potato settings followed by frying at a high temperature (~190) produces better fries than either double frying or boiling then frying does.

  138. Re: Don't like the science? Wait a few years by mapkinase · · Score: 1

    You are a moron who can't think for himself, a blithering parrot repeating obnoxious atheistic mythology

    --
    I do not believe in karma. "Funny"=-6. Do good and forbid evil. Yours, Oft-Offtopic Flamebaiting Troll.
  139. Re: Don't like the science? Wait a few years by mapkinase · · Score: 1

    Exacto mundo. Finally some sense.

    --
    I do not believe in karma. "Funny"=-6. Do good and forbid evil. Yours, Oft-Offtopic Flamebaiting Troll.
  140. Re:Don't like the science? Wait a few years by Anonymous Coward · · Score: 0

    You should observe more than 1% of human history. Then you would know how laughably wrong you are.

  141. Re:Don't like the science? Wait a few years by js290 · · Score: 1

    or you can assume that our body evolved mechanism to deal with the recurring lack of food and periods of fast might be where you are the sharpest. This would definitively be required to be able to find food. To the opposite, the constant influx of food is not "natural" to the body.

    George Cahill wrote a paper called Fuel Metabolism in Starvation that describes a lot of that. Our liver converts fatty acids to ketone bodies. One of the papers he references: BETA-HYDROXYBUTYRATE: THE MOST EFFICIENT FUEL Veech and colleagues discovered that administering -hydroxybutyrate to the perfused rat heart in place of glucose increased work output but decreased oxygen consumption (35). http://bit.ly/2AI7LUt

    Nassim Taleb's probabilistic structure for fasting: http://bit.ly/2ivHC5d

    --
    "Tempers are wearing thin. Let's just hope some robot doesn't kill everybody." --Bender
  142. Re:Don't like the science? Wait a few years by Anonymous Coward · · Score: 0

    I can't speak for all religions, but my religion has a tradition of fasting in relation to your fourth point: discipline.

    Periodic abstinence from rich foods is intended to strengthen the mind (will) over the body. And hopefully with a strong will we can abstain from the truly serious sins.
    Secondary reasons for being a little hungry:
    - reminds us to pray
    - means we appreciate the food when we can eat it

    Needless to say, if someone is unable to fast (ill, young, elderly, pregnant, etc) then all bets are off e.g. no one expects a pregnant / nursing mother to restrict her diet. Fasting is expected of those who are fit and healthy.

    Anyhow, just wanted to dispel some myths. Plenty of people here know virtually nothing about the major religions - and that's fine. However it does mean that we often see comments that are WAY off the mark. I suspect that, more often than not, my fellow religious adherents do what I do: just ignore the nasty comments and move on.

  143. Re:Don't like the science? Wait a few years by Anonymous Coward · · Score: 0

    Here is the definition you might be looking for : https://www.dictionary.com/bro...

  144. Re:Don't like the science? Wait a few years by Obfiscator · · Score: 1

    I agree with the need the distinguish between the scientific method and "Science", and I would argue that scientific literacy is just as much about understanding the scientific method and applying it broadly as it as about knowing a collection of scientific facts.

    That being said, what alternative to psychology do you propose? I will not argue that psychology has ruined lives. I am sure other fields (including the harder sciences) have similar dark spots on their records. Starting from the premise that given a lack of evidence all possibilities must be considered equally probable, new sciences use observations to make hypotheses. These hypotheses represent the best use of available evidence. They may be wrong, but they tip the scales towards certain possibilities, i.e., they increase our confidence that a given outcome is true.

    People often discount the results of studies due to flaws in the study design or execution. These flaws are valid critiques, and they certainly need to be addressed in future work. However, if you do not present evidence showing that these flaws significantly impact the results, our original premise above says it is equally likely that the flaws do not impact the results. Therefore, what justification is there for ignoring the results? No study is perfect (I have yet to read a paper in chemistry or physics which is above reproach, including all the ones I've written), but I feel that disciplines closer to everyday life experience much more frequently this situation.

    This may be the difference between science and religions. Science says that if everyone follows the scientific method, humanity will eventually arrive at the truth. It does not say that the current scientific understanding of the world is the truth, or that any individual living today will ever know truth. This distinction is vital, and perhaps not emphasised enough, likely due to the type of people mentioned in the previous paragraph who use criticism as a way to ignore results that they don't like, as opposed to accepting results they don't like as being the current "best guess" while using valid criticism to dig deeper in the future.

    --
    "Nothing shocks me. I'm a scientist." -Indiana Jones
  145. Re:Don't like the science? Wait a few years by Luckyo · · Score: 1

    You should take your own advice.

  146. Re: Don't like the science? Wait a few years by Anonymous Coward · · Score: 0

    You are a moron who can't think for himself, a blithering parrot repeating obnoxious atheistic mythology

    Poor little angry, autistic Christian, literally waiting for God to solve global warming. Your entire religion was founded when a Jewish carpenter got caught interfering with children and invented a really involved excuse on the spot. You've just got a bit caught up in the fan fiction scene that developed around it, in much the same way as you would have done in Star Wars or Lego if you'd had a better upbringing.

  147. Re:prove me wrong by TomGreenhaw · · Score: 1

    While anecdotal, I've had a similar experience as have many others. Several years ago, I had a serious issue with my gall bladder. I ate nothing solid for 6 days and had IV fluid only for 5. During this period I lost 9 pounds. I too did the math and my baseline metabolism should only have accounted for maybe 3 pounds. The weight of my gall bladder was negligible.

    Other posters have pointed to water weight and this is likely a big part of the missing weight loss effect, but cannot explain all of it.

    I suspect that the gut has something to do with this effect as well. We have between 2 and 6 pounds of gut flora and fauna. I suspect when you don't eat, this bacteria gets eliminated and is another contributing factor in temporary weight loss after extended fasting.

    It could also lead to long term benefits by resetting the population of gut bacteria to a more healthful balance depending upon what you eat after a period of extended fasting.

    --
    Greed is the root of all evil.
  148. Re:Look for the agenda by ChrisMaple · · Score: 1

    Use fresh potatoes, cut them and soak them in cold water before frying.

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  149. Re:Don't like the science? Wait a few years by ChrisMaple · · Score: 1

    "Natural" is irrelevant. The digestion of food generates free radicals; that's bad. By limiting the amount of time that the body is exposed to free radicals, and limiting their quantity, health improves. That's accomplished by choosing the right foods, not eating too much, and having extended periods in which no food is ingested. Apparently, the lower end of the range for "extended" is about 14 hours, although the research on this is rather sparse so far.

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  150. Re:Don't like the science? Wait a few years by ChrisMaple · · Score: 1

    Non-religious societies are a modern invention. All ancient societies were religious, the ones that were successful and those that weren't. No logical conclusion as to the survival value of religion is possible; nor can confounding factors be eliminated.

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  151. Re:Don't like the science? Wait a few years by ChrisMaple · · Score: 1

    Claiming that something is science, as psychologists like to do, does not make it science.

    Science does not require faith; the two are mutually exclusive.

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  152. Re: Don't like the science? Wait a few years by ChrisMaple · · Score: 1

    The food pyramid has varied a lot over time, occasionally featuring 3 protein categories: meat, fish, dairy.

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  153. Re:Don't like the science? Wait a few years by ChrisMaple · · Score: 1

    Caloric restriction, although not the same as fasting, is well-established as extending average and maximum life.

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  154. Re:prove me wrong by ChrisMaple · · Score: 1

    Even not allowing for water loss, it's possible to drop ten pounds in a week. Exercise uses calories, and it's not particularly difficult to do 600 calories of exercise per hour.

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  155. Re:Don't like the science? Wait a few years by Luckyo · · Score: 1

    You cannot make that statement in good faith, as there is insufficient data. All we know is that religious societies were the only ones to survive the series of contacts with other societies that occurred all over the planet as humanity entered the era that is known history.

  156. For the illiterate by GillBates0 · · Score: 1

    The swastika (as a character å or å) is a geometrical figure and an ancient religious icon in the cultures of Eurasia, used as a symbol of divinity and spirituality in Indian religions.[1][2][3][4] In the Western world, it was a symbol of auspiciousness and good luck until the 1930s, when it became a feature of Nazi symbolism as an emblem of Aryan race identity and, as a result, was stigmatized by association with ideas of racism and antisemitism.[5][6]
    https://en.m.wikipedia.org/wik...

    --
    An Indian-American Hindu committed to non-violent thought/speech/action alarmed by the global explosion of radical Islam
  157. Re:Look for the agenda by angel'o'sphere · · Score: 1

    I think you forgot the buds of the extinguished cigarets?

    --
    Cost free eBook I read (by iBook/Kobo/Amazon/ObookO/Gutenberg etc.): "The Green Odyssey" by Philip Jose Farmer.
  158. Re: Look for the agenda by angel'o'sphere · · Score: 1

    Artificial sweeteners mess up the bodies insulin balance.
    E.g. as soon as you have sweet taste in your mouth the body already starts emitting insulin.
    However that level is "to high" in relation to the true blood sugar level, hence instead of "digesting" the sugar it is transported to the fat cells, and converted into fat. Insulin is also responsible to transport ordinary fat to the fat cells. So while the sweetener itself has no calories, it messes up how the body is treating calories. And it messes up how the pancreas reacts and produces insulin.
    Needless to say: when a good chunk of the calories you just ate simply "vanish" in the fat cells, you are sooner hungry again.

    --
    Cost free eBook I read (by iBook/Kobo/Amazon/ObookO/Gutenberg etc.): "The Green Odyssey" by Philip Jose Farmer.
  159. Re: Don't like the science? Wait a few years by angel'o'sphere · · Score: 1

    And every country had/has a different one.

    The problem is: people have no common sense anymore. Unless you have a study, they don't believe anything. And studies are perhaps rigged to show what they should show.

    So instead of reading news articles about studies, why not read a book? Why not watch what healthy people do? And then again, having some extra pounds is not bad.

    The parent thinks fasting is a religious thing, which it is not really. It got incorporated into two religions, Christianity and Islam copied it from there. Christians proclaim they fast because of either Jesus might have fasted 40 days in the desert (but they only do 14 days, rofl) or because of preparation for the easter celebrations.

    Fact is: Christians started around 200 - 400 with fasting. And for a very simple reason: historically they did it anyway, either they could eat the rest of their remaining seeds, or use them as intended: put them in the soil. The idea to fast comes from the northern european regions, where they simply had no food. And has nothing to do with any "religion". Albeit the religions conquered every celebration of the natives ... otherwise it was a bit difficult to convince them :D

    See e.g. Erntedank, the european version of "thanksgiving": https://germanfoods.org/german...

    Why people try to dispute that fasting is actually healthy for the body is beyond me.

    --
    Cost free eBook I read (by iBook/Kobo/Amazon/ObookO/Gutenberg etc.): "The Green Odyssey" by Philip Jose Farmer.
  160. Re:Look for the agenda by angel'o'sphere · · Score: 1

    I guess it helps that we write % on the bottles and the murricans some strange "proof" number (actually it is just 2x the percentage, but how retarded can a nation be?)

    --
    Cost free eBook I read (by iBook/Kobo/Amazon/ObookO/Gutenberg etc.): "The Green Odyssey" by Philip Jose Farmer.
  161. Re:Don't like the science? Wait a few years by zieroh · · Score: 1

    You keep using that word, I don't think it means what you think it means.

    That is actually subtly incorrect. Try again.

    --
    People who say "sheeple" have about as much sophistication as an AOL user, and in fact are probably actually AOL users.