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User: Tony+Isaac

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  1. While it is true that your genome changes, the probability of change varies widely across the genome. Some locations (SNPs) are know NEVER (or nearly never) to change, others change every few generations, and still others change so often that reading them is meaningless. All of the DNA tests out there focus on SNPs that change only rarely, as in, once every few generations. Focusing on these SNPs makes the tests highly reliable as an indicator of the presence of a specific mutation.

  2. They're not actually reading your DNA sequence

    While you are correct, this does not reduce the accuracy or usability of tests done by a microarray. All of these tests, including whole-genome tests, use statistical probabilities to read every result they find. The result is a process that has proven extremely reliable.

    For Smith-Lemli-Opitz syndrome specifically, it is possible to use mass-market DNA tests to determine whether you have the mutations that correlate with the syndrome.

    https://www.snpedia.com/index....

  3. Re:At that point I move to Edge or FF on Chrome 70's Upcoming Security Change Will Break Hundreds of Sites (techcrunch.com) · · Score: 1

    Because, of course, Microsoft is so much more respectful of privacy than Google!

  4. A programming language endorsement from... on Economics Nobel Laureate Paul Romer Is a Python Programming Convert (qz.com) · · Score: 1

    an expert in economics?

  5. Re:Never tell anybody anything on Voice Phishing Scams Are Getting More Clever (krebsonsecurity.com) · · Score: 1

    Or, if the caller isn't a friend or family member, let it go to voice mail, always. If it's a business, and it's important, they can leave a message. Usually, the phishers won't. If they do, call back on the published number, not the number they leave.

  6. Re:Whoa. on Voice Phishing Scams Are Getting More Clever (krebsonsecurity.com) · · Score: 1

    Or better yet, don't answer calls from businesses. If it's important, they can leave you a message. They usually won't. If they leave a message with a number to call, disregard the number and call the published number.

  7. Skype has the same auto suggestions that are just stupid. Unfortunately, I don't think there's a way to turn them off.

    Are people really so unable to type 3 word answers without a special suggestion?

  8. I suppose you'll want bug and security fixes, plus enhancements, for Windows 7. There's a name for the version of Windows with all those things, it's called Windows 10.

    There's nothing inherently more stable or safe about Windows 7 than Windows 10. In my experience, issues like BSODs are getting less frequent on Windows 10 than they ever were on Windows 7.

  9. Re:windows makes it hard on Windows 10 October 2018 Update is Deleting User Data For Many (windowscentral.com) · · Score: 1

    In UN*X (BSD/Linux/...) all user files and configs are under one directory, where under Windows the files are spread all over creation

    My experience is the opposite. On Windows, files are always (these days) kept in a well-defined set of special-purpose folders, such as Documents, Photos, AppData, and so on. On some Ubuntu machines that I have to maintain, configuration and application files are WHO KNOWS where, sometimes under the user's home folder.

  10. Not even close to "mobile Windows" on Microsoft Is Embracing Android As the Mobile Version of Windows (theverge.com) · · Score: 1

    Have you tried the app? All it does is let you remotely control texting and photos access from your PC. It doesn't let you run Android apps on your PC, it doesn't even let you do a sort of "remote desktop" to your phone. It's much simpler than that.

  11. What's old is new again on New Autonomous Farm Wants To Produce Food Without Human Workers (technologyreview.com) · · Score: 1

    In the 1940's, my grandfather had a device for his farm tractor that would allow him to plow one furrow around a field. The device then took over, guiding the tractor in tighter and tighter circles until the field was completely plowed. People would stop by the side of the road just to gawk. Somehow, it never really caught on! I wonder if these new-fangled robots will do any better.

  12. Toys R Us didn't die because of financial mismanagement or poor sales. It was bought by investors, who borrowed a lot of money to complete the sale, and then made Toys R Us pay back the loans. The downturn of 2008 was just too much The creditors kind of got what they had coming, agreeing to such a highly leveraged deal.

    These creditors then dug their hole deeper by deciding to sell off the real estate used for the stores...before finally coming to their senses and realizing they were throwing something valuable away. Now they'll have to rebuild a lot of what was already lost. Toys R Us may come back, but it won't be as big or as good for quite some time.

  13. Bonuses come and go anyway on Amazon Is Eliminating Bonuses, Stock Awards to Help Pay for Raises (bloomberg.com) · · Score: 1

    I'd rather have a higher base salary and less bonuses, than lower base salary and higher bonuses. That's because bonuses are never guaranteed.

    This seems like a win for Amazon employees.

  14. Still pretty limited on Microsoft Announces App Mirroring To Let You Use Any Android App On Windows 10 · · Score: 1

    After trying this feature, I see some pretty serious limitations.
    1. It only does text messages and the "stock" Android photos app.
    2. In the messaging app, it does not show any pictures that are in a message thread.
    3. It does NOT sync with Google Photos.

    I was hoping for something more like a remote desktop, but hey, they're trying.

    For text messages on your PC, Google Messages for Web is better--it handles photos as well as text.

  15. Actually, it turns out that just about any Android phone can opt out. Several of my co-workers did not get the alert because they had turned off Amber alerts in their phones' settings.

  16. Re:CORRECTION for android users. on Cellphones Across the US Will Receive a 'Presidential Alert' at 2:18 pm Eastern Today (nytimes.com) · · Score: 1

    Actually, it turns out that just about any Android phone can opt out. Several of my co-workers did not get the alert because they had turned off Amber alerts in their phones' settings. No special OS required.

  17. Re:Important caveat on Microsoft 'Re-Open Sources' MS-DOS on GitHub (microsoft.com) · · Score: 1

    I would suggest that it didn't get good until 5.0, when it finally introduced long file names.

  18. $10 million vs. $100 billion? on Can DuckDuckGo Become the Anti-Google? (marketplace.org) · · Score: 1

    Google's annual revenues are over $100 billion. It uses a significant chunk of that to update and improve its search engine.

    Google has achieved its level of success and usefulness by spending money, lots of it. It's not enough to have the right philosophy or algorithm. Maintaining and improving a project as big as Google Search requires a ton of money, and will continue to do so.

    It's going to be really tough for DuckDuckGo to reach a level of sophistication remotely close to Google's.

  19. Sure, just like Chrome OS is the anti-Microsoft on Can DuckDuckGo Become the Anti-Google? (marketplace.org) · · Score: 1

    Chrome OS works nice for grandma, who just wants email and a Web browser, and is confused by all the other features of Windows or Android. Everybody else needs a "real" OS. (This is not mean to disparage Chrome OS, only to point out its limitations.)

  20. Re:A worrying lack of imagination on Moon is Stepping Stone, Not Alternative To Mars, NASA Chief Says (scientificamerican.com) · · Score: 1

    On the other hand, if you've never succeeded in boating across the great lakes, you'd better not try the Atlantic!

  21. Working for a company that uses COBOL on Do You Know Cobol? If So, There Might Be a Job for You. (wsj.com) · · Score: 1

    I wrote COBOL back in the day, moved to C++ ASAP. But it's not the language. A company that is still using COBOL also has entrenched, archaic ways of doing EVERYTHING. Sorry, not interested in the least!

  22. Older is wiser? I'm shocked! on Millennials More Likely To Fall For Scams Than Baby Boomers (washingtonexaminer.com) · · Score: 5, Insightful

    So the school of hard knocks teaches life skills? Wow!

    When Baby Boomers were young, they were stupid too.

  23. Re:unintended consequences on Mosquitoes Genetically Modified To Crash Species That Spreads Malaria (npr.org) · · Score: 1

    So you're saying we SHOULDN'T want to make more of Africa inhabitable?

  24. Re:Graduate students on MIT's Elegant Schoolbus Algorithm Was No Match For Angry Parents (bostonglobe.com) · · Score: 1

    Get "back" to 9 to 5? Study history. Before Henry Ford, people commonly worked six day weeks, 10-12 hour days. We have it pretty darn good these days.

  25. Graduate students on MIT's Elegant Schoolbus Algorithm Was No Match For Angry Parents (bostonglobe.com) · · Score: 1

    If you've ever worked with a fresh college grad, you know that they are very, very junior. College does not teach students how to be software engineers, it only teaches them how to write code, and maybe a bit of logic theory. To be worth much in business, it takes a few years of experience.

    Missing the actual reaction of humans who use a system (in this case, parents dealing with bus schedules) is very typical for a young person just out of school, or in this case, still in school.