The algae themselves don't cause the decrease in oxygen. Algae are photosynthetic organisms. Oxygen is depleted when the algae die and are subsequently decomposed by various bacteria.
One would assume that the rate of algal growth would be controlled by limiting the input of some nutrient like phosphorus, thus eliminating the issue of blooms and die-offs.
> As far as Harvard vs MIT, Harvard's medical, law, and business schools are still highly prestigious. I don't know of anybody who went to MIT to study those fields, although I'm sure they offer them (at least undergrad level equivalents).
MIT's Sloan is the 4th ranked business school in the nation...
You can't draw that conclusion without knowing the pathways involved in expression of INK4.
Extracellular signalling pathways, such as G-coupled protein receptor pathways, may be key to INK4 expression levels. If that is the case, embryonic stem cells would likely undergo the same INK4 suppression as adult stem cells, whether they be transplanted or naturally occuring.
The key is then not the source of the stem cells but modulation of protein expression in the stem cells you have.
>Radiation sterilizes but also kills proteins we need and thus we eat more.
Your digestive system does a good job of "killing" proteins you eat. What, you think you absorb whole proteins from your meal and they magically start doing their thing?
Proteins (kinases in particular) have this lovely trend where they have multiple names, all of which are acronyms. Example: Flk-1/KDR/VEGFR-2 are the same protein. Often the problem comes from the gene and the protein having different names, but people invariably end up using one in place of the other.
The religion being promoted here is atheism, or agnosticism, or any of a multitude of others. You see, "science" is a religion in the broadest sense (and lawyers like the broad sense). What many people forget is that by expressly denying something, you are actively asserting the opposite philosophy (in this case, "religion X" versus "everything which is not religion X". In the case of certain religions, all belief systems which exclude that religion are themselves a form of religion. That is, "no religion" is itself a religion (contrary to popular belief).
You confuse belief systems and religion. Religions are a subset of belief systems that are tied by a common denominator: the supernatural. Refutation of the supernatural does not suppose the belief in some different set of supernatural beliefs. It is perfectly possible to construct an argument against a belief in God (positive atheism) using pure logic by attacking the definition of what it is to be "God." This is not a religious argument in that it does not in any way invoke the supernatural in its arguments.
You probably won't "accept" "my" "tainted" "science" "either" "but" here it is anyway. I'll leave it as an exercise to the listener to map out the increasing levels of variation among DNA sequences through the various evolutionary branches of the organismal kingdoms. Bonus points for finding highly conserved sequences that relate to core protein functionality.
BLAST Results
Sequence 1 gi 28178824 Homo sapiens isocitrate dehydrogenase 1 (NADP+), soluble (IDH1), mRNA Length 2339 Sequence 2 gi 57116681 Mycobacterium tuberculosis H37Rv, complete genome
Just a clarification, Gleevec(STI571/Imatinib) isn't an enzyme. Its a small-molecule tyrosine kinase inhibitor that binds to the kinase Abl (which in chronic myeloid leukemia is constituative activated through fusion with the Bcr protein). The drug binds to ATP-binding pocket in the catalytic domain of Abl.
Gleevec happens to be the first FDA-approved kinase inhibitor. The field of kinase inhibitors for use in cancer is now quite large, although approval of new kinase ihibitor drugs has been slow.
The problem is that this press release is incredibly short on details. They appear to be making the claim that they have a product that will replace conventional PCR equipment when, in fact, this is not the case.
Microfluidic heating methods only significantly increase PCR rates in cases in which the amplicon length is less than 1,000bp. In fact, the average amplicon length in a recent review of microfluidic PCR devices (Analytical Chemistry, 77(12):3887-93) is only 330bp. Dependending on what polymerase is used, a 330bp piece of DNA can be replicated in 10-20 seconds. This, obviously, is a completely different situation from one in which a researcher is amplifying a 7kb vector in which elongation is the rate-limiting step. I'm sure that microfluidic devices could be adapted to work with amplicon lengths >1kb, but at that point the reaction rate improvements become negligible. Microfluidic PCR lends itself primarily to SNP genotyping, not general research.
Furthermore, the difficulty inherent in working with nanoliter volumes of reagents makes these microfluidic PCR devices somewhat less useful for general lab use. Naturally, they mesh well when coupled with lab-on-chip applications, but again that is currently a niche use.
Traditional thermocyclers aren't going anywhere any time soon. They're cheap, they're functional, and they're flexible.
CE DNA sequencing is orders of magnitude faster than old-style gel sequencing. For some applications, DNA microarrays can get you the necessary information in a few minutes.
These days the only people that use acrylamide gels for sequencing are undergraduates with no money.
Slashdot Mirror
Iatrogenic CJD is caused by natural hGH harvested from cadavers, not rhGH made in a lab.
I'm pretty sure they don't use cadaver hGH anymore.
Benzoate is not metabolized into benzene.
m isc/benzoate.html
http://www.chem.qmul.ac.uk/iubmb/enzyme/reaction/
The algae themselves don't cause the decrease in oxygen. Algae are photosynthetic organisms. Oxygen is depleted when the algae die and are subsequently decomposed by various bacteria.
One would assume that the rate of algal growth would be controlled by limiting the input of some nutrient like phosphorus, thus eliminating the issue of blooms and die-offs.
> As far as Harvard vs MIT, Harvard's medical, law, and business schools are still highly prestigious. I don't know of anybody who went to MIT to study those fields, although I'm sure they offer them (at least undergrad level equivalents).
MIT's Sloan is the 4th ranked business school in the nation...
Why would you decode the AC3? Use passthrough.
I find that almost nobody understands that there is no "cure for cancer."
You can't draw that conclusion without knowing the pathways involved in expression of INK4.
Extracellular signalling pathways, such as G-coupled protein receptor pathways, may be key to INK4 expression levels. If that is the case, embryonic stem cells would likely undergo the same INK4 suppression as adult stem cells, whether they be transplanted or naturally occuring.
The key is then not the source of the stem cells but modulation of protein expression in the stem cells you have.
Its almost as if you didn't even read the parent...
There are Hypertransport add-in connectors (HTX connectors) on some server motherboards that would be much better suited for this sort of application.
Why would you think you would have to upgrade your computer to run Office 2007?
I'm running the Beta on a 5 year old system and it runs faster than Office 2003 by a fair margin.
I could have sworn that I read this comment somewhere else....
>Radiation sterilizes but also kills proteins we need and thus we eat more.
Your digestive system does a good job of "killing" proteins you eat. What, you think you absorb whole proteins from your meal and they magically start doing their thing?
Tell that to Etymotic.
Proteins (kinases in particular) have this lovely trend where they have multiple names, all of which are acronyms. Example: Flk-1/KDR/VEGFR-2 are the same protein. Often the problem comes from the gene and the protein having different names, but people invariably end up using one in place of the other.
Ah yes, the secret undocumented Microsoft super-API. That mythical meme never seems to go away.
Tell that to Mr. Peltier!
That, my friends, is quality ownage.
You confuse belief systems and religion. Religions are a subset of belief systems that are tied by a common denominator: the supernatural. Refutation of the supernatural does not suppose the belief in some different set of supernatural beliefs. It is perfectly possible to construct an argument against a belief in God (positive atheism) using pure logic by attacking the definition of what it is to be "God." This is not a religious argument in that it does not in any way invoke the supernatural in its arguments.
Just a clarification, Gleevec(STI571/Imatinib) isn't an enzyme. Its a small-molecule tyrosine kinase inhibitor that binds to the kinase Abl (which in chronic myeloid leukemia is constituative activated through fusion with the Bcr protein). The drug binds to ATP-binding pocket in the catalytic domain of Abl.
Gleevec happens to be the first FDA-approved kinase inhibitor. The field of kinase inhibitors for use in cancer is now quite large, although approval of new kinase ihibitor drugs has been slow.
The problem is that this press release is incredibly short on details. They appear to be making the claim that they have a product that will replace conventional PCR equipment when, in fact, this is not the case.
Microfluidic heating methods only significantly increase PCR rates in cases in which the amplicon length is less than 1,000bp. In fact, the average amplicon length in a recent review of microfluidic PCR devices (Analytical Chemistry, 77(12):3887-93) is only 330bp. Dependending on what polymerase is used, a 330bp piece of DNA can be replicated in 10-20 seconds. This, obviously, is a completely different situation from one in which a researcher is amplifying a 7kb vector in which elongation is the rate-limiting step. I'm sure that microfluidic devices could be adapted to work with amplicon lengths >1kb, but at that point the reaction rate improvements become negligible. Microfluidic PCR lends itself primarily to SNP genotyping, not general research.
Furthermore, the difficulty inherent in working with nanoliter volumes of reagents makes these microfluidic PCR devices somewhat less useful for general lab use. Naturally, they mesh well when coupled with lab-on-chip applications, but again that is currently a niche use.
Traditional thermocyclers aren't going anywhere any time soon. They're cheap, they're functional, and they're flexible.
Thank you. You saved me from having to post that.
CE DNA sequencing is orders of magnitude faster than old-style gel sequencing. For some applications, DNA microarrays can get you the necessary information in a few minutes.
These days the only people that use acrylamide gels for sequencing are undergraduates with no money.
You know that the CPU is used for disk I/O commands, right?
Someone obviously doesn't understand that its a research project.