I think your "basic tolerable dose" is the same thing. In this case, it is being performed on healthy individuals, since it is a vaccine. As for your theory on their Phase III trial, I bet you are right. Same thing with AIDS vaccines, they will see how many contract. Of course one of the most famous clinical trials ever was done on a vaccine, the Salk Polio Vaccine. The study was carried out on over a million young children and was the largest clinical trial ever, I believe it still is with possible exception of the Women's Health Initiative.
This is a Phase I clinical trial. There are typically 3 phases to each clinical trial, with Phase III being "official" statistical study. Phase III is "gold standard" FDA phase, where you prove statistically that your treatment works.
What is a Phase I trial? It is typically used to determine a maximum tolerable dose (MTD). And how is that done? Something called "dose escalation" is used. That means you start off with a very low dose typically given to 3 patients, and if no toxicities (bad things) happen, you raise the dose. You keep doing this until you observe two toxicities in two consecutive groups (typically). Many times the volunteers in Phase I trials are terminally ill and willing to try anything.
If you are not terminally ill, perhaps waiting for the Phase III trial to join is the best bet, when they have already figured out the "maximum tolerable dose".
If the music is so bad, then why are people downloading it? Fact is, they want the music, but if there are two options, one to pay 10 dollars, and one to get it free, guess which one most people choose. Is 10 dollars really that much money to spend on a CD? I just spent 40 dollars on a CD the other day; it had a PC game on it though. So why is it ok for a PC game to cost 40 dollars when it comes on the same medium as an audio CD?? Why don't slashdotters complain about the cost of PC games? Certainly it makes more sense! Oh wait, maybe its because unlike music, they have a sense of how much time and money goes into making a computer game.
What Woz has done is created a paradigm whereby individuals can harness the power of this technology to enable their lives
I'm suggesting you not attend any meetings where MBA's are present for at least 1 month starting immediately. It is your only hope at this point! Please call me if you need any support through your ordeal.
More classic sentence structure
on
Inkblot Passwords
·
· Score: 4, Funny
Here is some more of our favorite Slashdot composition style for your pleasure.
"Microsoft Research a new way to get users to not only develop, but remember more secure passwords can be achieved through using inkblots."
Makes one want to weep really.
Re:helping the handicapped illegal?
on
Hacking the XBox
·
· Score: 1
Now *that* makes some sense to me, thanks!
Re:helping the handicapped illegal?
on
Hacking the XBox
·
· Score: 1
Allow me to rephrase what I believe the original author intended to say. He or she did say that helping the handicapped was illegal, but I don't think that's what the intent was. Here is a translation.
Officially, Huang's excellent book is about helping the handicapped, not about hacking the XBox, since that would be against the law. Huang was forced by the DMCA to hide his hacking under the cloak of 'humanitarianism' because this is one of the few legitimate uses given a small amount of protection by the law.
There does that make more sense? It sure does for me!
Would someone please explain in the "other English" simply what the summary of this article is trying to state? I have unusally high reading comprehension skills, but that paragraph has withstood repeated attempts on my part to retrieve any useful information from it!
Slashdot Mirror
I think your "basic tolerable dose" is the same thing. In this case, it is being performed on healthy individuals, since it is a vaccine. As for your theory on their Phase III trial, I bet you are right. Same thing with AIDS vaccines, they will see how many contract. Of course one of the most famous clinical trials ever was done on a vaccine, the Salk Polio Vaccine. The study was carried out on over a million young children and was the largest clinical trial ever, I believe it still is with possible exception of the Women's Health Initiative.
This is a Phase I clinical trial. There are typically 3 phases to each clinical trial, with Phase III being "official" statistical study. Phase III is "gold standard" FDA phase, where you prove statistically that your treatment works.
What is a Phase I trial? It is typically used to determine a maximum tolerable dose (MTD). And how is that done? Something called "dose escalation" is used. That means you start off with a very low dose typically given to 3 patients, and if no toxicities (bad things) happen, you raise the dose. You keep doing this until you observe two toxicities in two consecutive groups (typically). Many times the volunteers in Phase I trials are terminally ill and willing to try anything.
If you are not terminally ill, perhaps waiting for the Phase III trial to join is the best bet, when they have already figured out the "maximum tolerable dose".
If the music is so bad, then why are people downloading it? Fact is, they want the music, but if there are two options, one to pay 10 dollars, and one to get it free, guess which one most people choose. Is 10 dollars really that much money to spend on a CD? I just spent 40 dollars on a CD the other day; it had a PC game on it though. So why is it ok for a PC game to cost 40 dollars when it comes on the same medium as an audio CD?? Why don't slashdotters complain about the cost of PC games? Certainly it makes more sense! Oh wait, maybe its because unlike music, they have a sense of how much time and money goes into making a computer game.
Don't forget he also has attained citizenship in the Mushroom Kingdom.
but for the average lindows user
The average usually isn't very meaningful when n=1.
So how do you draw a virgin?
Trace this picture?
Why on earth did he pick one that goes DOWN? Why not pick one that goes up and right?
I think it might symbolize a flaccid penis since according to his FAQ, you aren't to think about sex if you are a hacker.
How is ending up broken into a dozen pieces considered doing "suprisingly well"???
The upgrade to VS.Net 2003 is/was only $30 (yes, thirty) for anyone with a copy of Visual Studio .Net. I don't know if this deal is still going on.
Whidbey is the code name for the next Visual Studio, not just C#.
john conmway, the other name in the opening, I believe was the inventor of life.
No, that was God. Wait, John Conway *is* God!
Please tell me you don't think that a device used to restrict water is a "damn".
That is *NOT* math, that is statistics. Please never mix those two up again!
84 per cent of CIOs in a recent survey said it hasn't affected their plans to implement Linux."
Didn't plan to before, still don't plan to.
You mean you don't get the same level of education at Southern Mississipi "University"??? We've been had!
Could someone help me with this one?
Charities and institutions think physical, Windows and money, so it's down to the geeks.
What the hell is he trying to say with that sentence?
I'm sure it will be banned, any day now, yep, right around the corner...
I got Photoshop 5 to run for like 10 minutes once.....
What about when you tried it on Linux though?
Could someone please post the story? I've been around here way to long to even begin thinking of clicking on a link with "gaping hole" in the text!
and later donated
Donated in the same way that my pimp Carlos donated me that "new" BMW last week.
What Woz has done is created a paradigm whereby individuals can harness the power of this technology to enable their lives
I'm suggesting you not attend any meetings where MBA's are present for at least 1 month starting immediately. It is your only hope at this point! Please call me if you need any support through your ordeal.
Here is some more of our favorite Slashdot composition style for your pleasure.
"Microsoft Research a new way to get users to not only develop, but remember more secure passwords can be achieved through using inkblots."
Makes one want to weep really.
Now *that* makes some sense to me, thanks!
Allow me to rephrase what I believe the original author intended to say. He or she did say that helping the handicapped was illegal, but I don't think that's what the intent was. Here is a translation.
Officially, Huang's excellent book is about helping the handicapped, not about hacking the XBox, since that would be against the law. Huang was forced by the DMCA to hide his hacking under the cloak of 'humanitarianism' because this is one of the few legitimate uses given a small amount of protection by the law.
There does that make more sense? It sure does for me!
Would someone please explain in the "other English" simply what the summary of this article is trying to state? I have unusally high reading comprehension skills, but that paragraph has withstood repeated attempts on my part to retrieve any useful information from it!
Thanks in advance!