Even if you could sythesize anything that nature can make, there isnt enough matter in the universe to make every small molecule that might be of interest to medicinal chemists. So how do you screen out the useless molecules and find ones that might have an effect on a druggable target? You use millions of years of evolution to your advantage and isolate compounds made by organisms. These "natural products" can be used to do high-throughput screening on your drug target.
I can't figure out what the hell you are talking about.
Once a drug is approved by the FDA, it can be prescribed by the doctor to treat anything. That means prescribing an antipsychotic to treat migranes, or a heart medicine to treat hair loss.
If someone discovered that vioxx cured cancer, and was able to get a clinical study that indeed proved this result to oncologists, patients win and pharmas lose.
My point is that if someone has figured out a way to treat their illness that they can prove, then they should get off their butt and do something about it. There are nonprofits for what seems like every illness in existance. These groups can and do make a difference.
Doctors are not some evil group that wants you to suffer with a disease. They are usually people that go into the profession to cure people. They dont develop the treatments either. They memorize what the symptoms and treatments are and act accordingly.
Now then, who develops the treatments? For the most part, drug companies do. They are also not evil people, but they ARE in it for the money because they have to be. They target chronic diseases where people will be treated for a long time, and acute diseases where they will make a lot of money. If during their research they discovered that say "Motion sickness pills cured migraines", the results would be completly ignored because there was no money to be made.
There are however other groups that do research into diseases. Academic and government labs. Many orphan diseases are researched by these groups and treatments have certainly come out from them.
Now whose fault is it that an easy cure is available that you know about, and it is not being used?
Its YOUR FAULT!
If you know how to cure a disease in a simple manner, dont just sit on your butt and bitch about the establishment. Make contacts with non-profit organizations in that area. Get them to give money to a lab that is qualified to test your treatment. Get them to publish the results. Until that time, no one will take it seriously. Science and medicine are full of stuborn people, but they will change their mind if presented with enough evidence.
Vaccines take years and years to get on the market. The safety testing can take decades, and there is very little money to be made in making new and better vaccines. There is an enormous risk of being sued, which can eliminate any profits and easily bankrupt the vaccine maker.
The technology to create many vaccines is very old because of these reasons, often dating back 50 years +.
We can make vaccines that are substantially better than what we have, but the government will have to get involved because no companies will ever do it.
There are more products out there than tennis shoes and bubble gum, and these products have a much higher profit margin than the 10 cents a chinese company makes per pair of shoes.
Americans have been benefited from the price of chinese manufactored goods for decades.
Kundi M, Mild K, Hardell L, Mattson M-O (2004): Mobile telephones and cancer - a review of epidemiological evidence. Journal of Toxicology and Environmental Health Part B 7:351-384, 2004
Link to the summary on NCBI. It is based on hundreds of studies, and seems to conclude that there is little or no evidence.
"The epidemiological evidence for a causal association between cancer and RF energy is weak and limited"
the only caution is "the existing epidemiology is limited and the possibility of epigenetic effects has not been thoroughly evaluated, so that additional research in those areas will be required for a more thorough assessment of the possibility of a causal connection between cancer and the RF energy from mobile telecommunications"
Im not too concerned about epigenetic. Maybe if my ears were located below my belt.
Even if cell phones induced tumors, we can't detect it with any current experiments. Maybe when more sensitive tools for detecting mutagenesis are developed, we will be better able to quantitate the effects. Until there is something concrete, I will keep on using my cell phone.
There has never been a study to my knowledge that has shown that cell phones cause cancer. I understand the need to throughly test Cell phone radiation, but IMO it's been throughly tested for years.
I just hope this study shows no effect like all the other ones, or we will have another good old fashion panic on our hands.
In underdeveloped countries, antibiotics are often used as the one and only line of defense against disease. Off patent antibiotics are cheap to manufactor and are shipped by the ton. Unfortunately this is where most of the antibiotic resistant strains come from. Its all about the evolution is all about numbers. Number of people with infections that are taking antibiotics improperly. Read some of the books by Laura Garrett for more info.
Whats the solution to the problem? Limit the number of antibiotics that are shipped to third world countries? Maybe, but its not going to happen.
The current by default solution is that the only antibiotics that are so expensive that they can only be purchased by rich countries will work. Hopefully they work for a few years, until the next super expensive antibiotic is developed.
I am a microbiologist, and I used to do drug discovery research. I feel that in the end this is a fight we will win. Eventually....
I've played quake with Dennis before. He really was incredible. Ive also played starcraft with him. He was very good, but certainly not at the professional level.
What's my point?
Even switching the type of video game that you play can make all the difference as to what level you can compete at. Tennis to Quake IV? Good Luck!
Hand eye coordination is required for tennis, basketball, and video games. If someone is great at one sport, chances are they will be good at another involving similar skills. This doesnt mean that they will be able to compete on a professional level. The best example I can give is Michael Jordan. Incredible basketball player, good golfer and baseball player.
Only time will tell if this tennis player has what it takes to play with professional gamers.
Diablo I and II, starcraft, 4 warcraft games. Almost every single game they have ever released has been a must have. Why does it suprise anyone that they probably have the best mmorpg ever made? Make the best game and apparently 5 million people will come.
Just to counter your first point. I was farming 2-3 stacks of icecap in an hour and Selling them for close to 20 gold a stack. I was averaging about 45 gold an hour which is 540 gold in 12 hours. Prices vary, and I have no doubt that they can easily make 400 gold in 12 hours since Im sure my method was not the most efficient way of farming.
I agree with you that WoW just doesn't have the end game that it needs for staying power. It is an exceptional game up until level 60.
I would like to remind you however that blizzard has an awsome track record for expansions. These have created far more balance in PvP(starcraft broodwar, frozen throne) than the originals had. The amount of end game content increase should be phenomenal also. http://www.blizzplanet.com/modules.php?action=Cont ent&pa=showpage&pid=144
Being a hardcore PvPer myself, I can only hope Blizzard meets my PvP expectations. I expect that until the new content is released, a lot of people will quit the game. World of Warcraft end game content seems like a place holder for the real game that will be released, and when it is, I expect most quitters will come back.
Based on Blizzard's track record, they take a long time to release games, but it is always worth the wait.
This has never been about doing the research into ID. People do research on Ghosts, psychic phenomenon and other areas that have very little evidence of their existance. Do I believe ghost exist? No. Do I think that research in the area should stop? No, because proving that they exist would be a huge discovery. And until researchers provide adequate proof, the existance of ghosts should not be taught in schools. I hold the same standards for ID.
What the hell are you talking about? PEOPLE work at drug companies, and they most certainly do care about curing people. Many of the people that work for drug companies have lost loved ones to cancer, heart disease, etc. That's the reason why many began careers in research.
That being said researchers don't necessarily get to pick their projects. They spend quite a bit of time working on cures for wrinkles and impotence as well as cancer.
One of the main reasons why michigan roads are so bad is due to a lack of weight restrictions for commercial semis. As a michigan driver, if this new concrete withstands weight better over time, I am all for it!
Slashdot Mirror
Even if you could sythesize anything that nature can make, there isnt enough matter in the universe to make every small molecule that might be of interest to medicinal chemists. So how do you screen out the useless molecules and find ones that might have an effect on a druggable target? You use millions of years of evolution to your advantage and isolate compounds made by organisms. These "natural products" can be used to do high-throughput screening on your drug target.
s ponge.html
Here is a lab that does this.
http://www.umich.edu/~lsi/institute/labs/sherman/
I can't figure out what the hell you are talking about.
Once a drug is approved by the FDA, it can be prescribed by the doctor to treat anything. That means prescribing an antipsychotic to treat migranes, or a heart medicine to treat hair loss.
If someone discovered that vioxx cured cancer, and was able to get a clinical study that indeed proved this result to oncologists, patients win and pharmas lose.
My point is that if someone has figured out a way to treat their illness that they can prove, then they should get off their butt and do something about it. There are nonprofits for what seems like every illness in existance. These groups can and do make a difference.
Doctors are not some evil group that wants you to suffer with a disease. They are usually people that go into the profession to cure people. They dont develop the treatments either. They memorize what the symptoms and treatments are and act accordingly.
Now then, who develops the treatments? For the most part, drug companies do. They are also not evil people, but they ARE in it for the money because they have to be. They target chronic diseases where people will be treated for a long time, and acute diseases where they will make a lot of money. If during their research they discovered that say "Motion sickness pills cured migraines", the results would be completly ignored because there was no money to be made.
There are however other groups that do research into diseases. Academic and government labs. Many orphan diseases are researched by these groups and treatments have certainly come out from them.
Now whose fault is it that an easy cure is available that you know about, and it is not being used?
Its YOUR FAULT!
If you know how to cure a disease in a simple manner, dont just sit on your butt and bitch about the establishment. Make contacts with non-profit organizations in that area. Get them to give money to a lab that is qualified to test your treatment. Get them to publish the results. Until that time, no one will take it seriously. Science and medicine are full of stuborn people, but they will change their mind if presented with enough evidence.
Only part of it and only for tetrahymena, not human. It is much more difficult for a number of reasons.
Vaccines take years and years to get on the market. The safety testing can take decades, and there is very little money to be made in making new and better vaccines. There is an enormous risk of being sued, which can eliminate any profits and easily bankrupt the vaccine maker.
The technology to create many vaccines is very old because of these reasons, often dating back 50 years +.
We can make vaccines that are substantially better than what we have, but the government will have to get involved because no companies will ever do it.
Why indeed would a chinese person or an Indian buy an american product?
t edsolutions/biomek/biomekfx_inst_dcr.asp
o rder/2001rank.html
What kind of products are you talking about?
Here's some products that you cant buy from non american companies
http://www.beckman.com/products/instrument/automa
http://www.boeing.com/commercial/
There are more products out there than tennis shoes and bubble gum, and these products have a much higher profit margin than the 10 cents a chinese company makes per pair of shoes.
Americans have been benefited from the price of chinese manufactored goods for decades.
Here are some fun statistics. I love the GDP per capita sections.
http://www.cia.gov/cia/publications/factbook/rank
Kundi M, Mild K, Hardell L, Mattson M-O (2004): Mobile telephones and cancer - a review of epidemiological evidence.
= Retrieve&db=pubmed&dopt=Abstract&list_uids=1601992 8&query_hl=3&itool=pubmed_docsum
Journal of Toxicology and Environmental Health Part B 7:351-384, 2004
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd
Link to the summary on NCBI. It is based on hundreds of studies, and seems to conclude that there is little or no evidence.
"The epidemiological evidence for a causal association between cancer and RF energy is weak and limited"
the only caution is "the existing epidemiology is limited and the possibility of epigenetic effects has not been thoroughly evaluated, so that additional research in those areas will be required for a more thorough assessment of the possibility of a causal connection between cancer and the RF energy from mobile telecommunications"
Im not too concerned about epigenetic. Maybe if my ears were located below my belt.
Even if cell phones induced tumors, we can't detect it with any current experiments. Maybe when more sensitive tools for detecting mutagenesis are developed, we will be better able to quantitate the effects. Until there is something concrete, I will keep on using my cell phone.
Any studies that show a possible association that doesnt have the same author/authors?
There has never been a study to my knowledge that has shown that cell phones cause cancer. I understand the need to throughly test Cell phone radiation, but IMO it's been throughly tested for years.
I just hope this study shows no effect like all the other ones, or we will have another good old fashion panic on our hands.
In underdeveloped countries, antibiotics are often used as the one and only line of defense against disease. Off patent antibiotics are cheap to manufactor and are shipped by the ton. Unfortunately this is where most of the antibiotic resistant strains come from. Its all about the evolution is all about numbers. Number of people with infections that are taking antibiotics improperly. Read some of the books by Laura Garrett for more info.
Whats the solution to the problem? Limit the number of antibiotics that are shipped to third world countries? Maybe, but its not going to happen.
The current by default solution is that the only antibiotics that are so expensive that they can only be purchased by rich countries will work. Hopefully they work for a few years, until the next super expensive antibiotic is developed.
I am a microbiologist, and I used to do drug discovery research. I feel that in the end this is a fight we will win. Eventually....
I've played quake with Dennis before. He really was incredible. Ive also played starcraft with him. He was very good, but certainly not at the professional level.
What's my point?
Even switching the type of video game that you play can make all the difference as to what level you can compete at. Tennis to Quake IV? Good Luck!
Hand eye coordination is required for tennis, basketball, and video games. If someone is great at one sport, chances are they will be good at another involving similar skills. This doesnt mean that they will be able to compete on a professional level. The best example I can give is Michael Jordan. Incredible basketball player, good golfer and baseball player.
Only time will tell if this tennis player has what it takes to play with professional gamers.
Computer simulations are currently not advanced enough to give you anything close to definitive answers on whether or not a drug will work in vivo.
Please stop posting troll-like comments.
My favorite site for game reviewsg ory=Massively+Multiplayer&date_filter=all&type=top _rated
t ings.asp
http://www.gamespot.com/games.html?platform=&cate
Another site that ranks games based on dozens of reviews(WoW has 60 reviews!)
http://www.gamerankings.com/itemrankings/simplera
The critics seem to agree that World of Warcraft is the best MMORPG ever made, but everyone is entitled to their own opinion.
Diablo I and II, starcraft, 4 warcraft games. Almost every single game they have ever released has been a must have. Why does it suprise anyone that they probably have the best mmorpg ever made? Make the best game and apparently 5 million people will come.
Just to counter your first point. I was farming 2-3 stacks of icecap in an hour and Selling them for close to 20 gold a stack. I was averaging about 45 gold an hour which is 540 gold in 12 hours. Prices vary, and I have no doubt that they can easily make 400 gold in 12 hours since Im sure my method was not the most efficient way of farming.
When we finish covering the surface of the sun with solar panels, I'll believe you.
http://www.nada.kth.se/~asa/dysonFAQ.html#WHAT
I agree with you that WoW just doesn't have the end game that it needs for staying power. It is an exceptional game up until level 60.
t ent&pa=showpage&pid=144
I would like to remind you however that blizzard has an awsome track record for expansions. These have created far more balance in PvP(starcraft broodwar, frozen throne) than the originals had. The amount of end game content increase should be phenomenal also. http://www.blizzplanet.com/modules.php?action=Con
Being a hardcore PvPer myself, I can only hope Blizzard meets my PvP expectations. I expect that until the new content is released, a lot of people will quit the game. World of Warcraft end game content seems like a place holder for the real game that will be released, and when it is, I expect most quitters will come back.
Based on Blizzard's track record, they take a long time to release games, but it is always worth the wait.
Six major patches have been released so far, with a seventh coming within the next month or so.
With the different dynamics of a MMORPG versus previous Blizzard games, how are the expansion teams separated from teams that work on patches?
what percent of the people on the WoW team are dedicated to each?
This has never been about doing the research into ID. People do research on Ghosts, psychic phenomenon and other areas that have very little evidence of their existance. Do I believe ghost exist? No. Do I think that research in the area should stop? No, because proving that they exist would be a huge discovery. And until researchers provide adequate proof, the existance of ghosts should not be taught in schools. I hold the same standards for ID.
What the hell are you talking about? PEOPLE work at drug companies, and they most certainly do care about curing people. Many of the people that work for drug companies have lost loved ones to cancer, heart disease, etc. That's the reason why many began careers in research.
That being said researchers don't necessarily get to pick their projects. They spend quite a bit of time working on cures for wrinkles and impotence as well as cancer.
One of the main reasons why michigan roads are so bad is due to a lack of weight restrictions for commercial semis. As a michigan driver, if this new concrete withstands weight better over time, I am all for it!
Please don't fear for your lives.
I wonder what the robots ping time is?
The chase camera existed back in quake 1. It would switch from area to area so you could view all the major fights, and track the movement of players.