"A dozen of the 14 compounds were still as potent as they were when they were manufactured, some at almost 100 percent of their labeled concentrations"
How can something be "almost 100 percent of labeled concentration" and "as potent as when they were manufactured"? Seems like an article trying to sensationalize non-news. Milk doesn't necessarily expire on it's expiration date either, in fact, different states have different requirements for when that date is suppose to be set. And of course drug manufactures must have *some* incentive to prolong the expiration dates, else they'd all be 3 months (or at least the same time frame). Longer expropriations mean you can manufacture more drugs in one run (and use the same workers to manufacture something else before the next run).
Some regulations actually encourage innovation (carbon credits). Moreover, without truth in advertising / some burden of proof that what you are putting out there in healthcare actually works, it's easy for a large company (l'll choose Merck since they seem to have no problem publishing fake data to this end) to claim they've made a drug that cures a particular disease causing funding in that field to evaporate.
Similarly, since there are no non-profit pharmaceutical manufacturers (due to the sheer cost), the issuing of drug patents (a form of regulation) are they only way to incentive the huge finical risk that a large scale (burden of proof) trial entails, and subsequent manufacturing equipment costs. As a researcher I wish this wasn't the case, but it seems even generic drug makers won't enter the market for a patent-free without some idea of what the market capacity is.
This is great timeing as it's not just the NYT that's discussing this. In the Febuary 18th issuse, Nature talks about an arxiv for biology called bioRxiv were biologist can post their pre-prints: http://www.nature.com/news/bio...
As a biologist frustrated with publication turnaround times, I took some time to encourage a collaborator to submit one of our manuscripts to bioRxiv this morning.
Actually, having found a similar therom when I was in HS geometry, I can tell you that in the US they would of spent the time to try an publish it only to have academic journal editors figure out it wasn't novel at all and make allegations of plagiarism...
It seems totally doable for a electrode array to do this if you can find a reason to convince the FDA of a need for higher density electrode arrays (the max is currently 256).
Manufactures like Imec are confident they can use photographic techniques and flexible circuit board technology to create a multi-electrode arrays (MEA) that meet the density requirements set in the BAA. The tricky part here is to ensure the final system is biologically compatible.
I was planning on applying to the grant using an optical approach but got delayed by an industry contact / didn't have time to vet other optical technologies before the abstract submission deadline. CRISPR-CAS9 editing is already in human trials for Parkinson's patients so getting FDA approval to use optogentic techniques to control human brains for extreme cases illnesses like quadriplegia and ALS could be doable in 4 years. And while readout of 100,000 neurons using optical methods and seems doable via implantable sensors, using optics for precise writing to 1 million neurons didn't seem possible in a fully implantable device without overheating the brain tissue, although it might be possible using a though skull fiber-optic technology. In any case, it's clear more development work would be needed in an optical approach vs an MEA based one.
This sort of thing has always been available for pharmaceutical manufacturing, but has been long overlooked on the research side. I've been at a few science research based engineering companies that collect this kind of data already, but don't do anything to analyse it unless something catastrophic happens. A software tool that could enable visualization of this data across experiments will extremely valuable as we remove technician to technician variation (via robotics) and a synthetic biology becomes more common place, and could prove as invaluable as well plate edge effect analysis already included in major bio-analysis software packages such as spotfire.
The issue with slashdot posters that don't RTFA before making complex arguments is that their argument is void when everything has already been clearly defined. FTFA:
“Principal investigators (PIs) on an NIH grant must contact NIH through their institution to seek prior approval for a change of institution. NIH grants are made to institutions, not to individuals. When a PI moves to another institution, the original grantee institution frequently agrees to relinquish the grant to the PIs new institution but NIH must approve this transfer. If the original grantee institution does not wish to relinquish the grant, they must seek NIH approval to appoint a new PI to the grant. NIH must assess whether the project can continue under the new scientific leadership at the original institution, and if so will approve a change in PI. If not, the grant is terminated.”
Actually, if all of you would stop arguing and RTFA, you'd note that there is clarity about all of this: 'UCSD—not Aisen— “is contractually obligated by its agreements with the NIH and research partners to maintain and safeguard data from clinical studies conducted by ADCS. ”'
Why is everyone posting speculation instead of actually reading the article? The reporter did all the homework; the article clearly states that there was a data management plan and that the Institution is in charge of managing the data:
UCSD—not Aisen— “is contractually obligated by its agreements with the NIH and research partners to maintain and safeguard data from clinical studies conducted by ADCS. ”
Dew formation depends on dirty water. If you remove the impurities in the air, then your condensention efficiencies will go down: https://www.youtube.com/watch?...
Seems like a non-issue as there is plenty of room for them to adapt, shifting from away from collision to more detailed versions of comprehensive that will cover minor dings, regular wear and tear and battery replacement.
p>If you really want to "get money out of politics," you need to (as much as possible) get politics out of the economy. (Ideologues will always lobby, and that's fine, because it's the crony capitalism and pay-to-play aspects that are most objectionable.) Which, of course, is not what many reformers want to do. Until they do, they are basically advocating spreading sugar around their picnic blanket, and then complaining about all the ants.
Check out Laurence Lessig's speech "We the People, and the Republic we must reclaim" . The premise is that there is no way to even start getting politics out of the economy (or any other sensible legislation) until we remove money from politics.
It is definitely no the first time it has been done with adult blood, this was done in in 2013
The scientists that published that just must not be up on their literature or the author is just confused and the scientists are trying to talk up their research.
FTA: "A touchpad configuration module has been added"
This is the one configuration took that has been missing from KDE since the upgrade from 3.5.
The activities based power management is also a long awaited feature (turn off powersaving / sleep / hybernate when in presentation mode).
Other than that the rest appears to be eye candy.
Still waiting for automatic activity settings based on locally sensed wifi.... (I still need to manually change my external monitor setting every time I get into work / home).
When is the last time you negotiated prices at the grocery store?
Well since the Reddit is the one forking over the money, their proposed model doesn't match grocery shopping either: "When was the last time you got to the checkout register and refused to buy products until the merchant agreed to your pricing?"
Fuck Microsoft and fuck google. Why should they expect the public to fund a specialized skill set that makes them money.
Why should any employer want the school system to educate students to do anything useful? Heck, why are we funding education at all? By your argument, employers that want people to be able to keep books (add and subtract), or email (read and write) or treat patients (science) should be funding these things them selves. This is the same sort of BS circular logic people like to give as to why we shouldn't tax companies that depend on public infrastructure (since they just pass the costs onto customers anyway). Stop jerking your self off to Ann Rand and wake up!
I don't get it!
If everyone (most people?) started using diceware and "there are [only] 60,466,176 different potential passphrases" wouldn't it be broken in less than a second if one can make "a trillion guesses a second"?
And this was before the citizens united decision - just goes to show you that publicly funded elections are the only way to prevent this sort of thing from happening...
Doesn't matter. If it says "parsley", which does nothing, then the rule is it's supposed to be parsley and nothing but parsley.
THIS is exactly why I don't understand why there's even a debate about GMO labeling. Not that I'd waste my time fighting to add it to the labels as I care more about residual chemical levels than genes from another edible plant. Nonetheless, cloned in genes that were never part of the product before == adulterated product.
If I were a mod, I won't know whether to mod you at Troll or Insightful:
Your history lesson on Buchanan and Pierce vs Lincoln was enlightening, but you are totally overlooking the shit-stained victory that is ObamaCare - At this point there's no way the republican's can appeal it, it would cause a mass uprising now that people realize Obamacare isn't really going to kill grandma, and makes it easier to stay insured (COBRA was a ripoff) if your unemployment insurance runs out, or if you decide to become an consultant....and there's something to be said about a passing a law that not even the Kennedy's or Clinton's could.
Slashdot Mirror
How can something be "almost 100 percent of labeled concentration" and "as potent as when they were manufactured"? Seems like an article trying to sensationalize non-news. Milk doesn't necessarily expire on it's expiration date either, in fact, different states have different requirements for when that date is suppose to be set.
And of course drug manufactures must have *some* incentive to prolong the expiration dates, else they'd all be 3 months (or at least the same time frame). Longer expropriations mean you can manufacture more drugs in one run (and use the same workers to manufacture something else before the next run).
I don't know, it sounds a lot like the FDA... which more or less works.
Some regulations actually encourage innovation (carbon credits). Moreover, without truth in advertising / some burden of proof that what you are putting out there in healthcare actually works, it's easy for a large company (l'll choose Merck since they seem to have no problem publishing fake data to this end) to claim they've made a drug that cures a particular disease causing funding in that field to evaporate.
Similarly, since there are no non-profit pharmaceutical manufacturers (due to the sheer cost), the issuing of drug patents (a form of regulation) are they only way to incentive the huge finical risk that a large scale (burden of proof) trial entails, and subsequent manufacturing equipment costs. As a researcher I wish this wasn't the case, but it seems even generic drug makers won't enter the market for a patent-free without some idea of what the market capacity is.
This is great timeing as it's not just the NYT that's discussing this. In the Febuary 18th issuse, Nature talks about an arxiv for biology called bioRxiv were biologist can post their pre-prints: http://www.nature.com/news/bio...
As a biologist frustrated with publication turnaround times, I took some time to encourage a collaborator to submit one of our manuscripts to bioRxiv this morning.
I for one welcome my new Slashdot overloads! Thanks for the positive changes guys!
Actually, having found a similar therom when I was in HS geometry, I can tell you that in the US they would of spent the time to try an publish it only to have academic journal editors figure out it wasn't novel at all and make allegations of plagiarism...
It seems totally doable for a electrode array to do this if you can find a reason to convince the FDA of a need for higher density electrode arrays (the max is currently 256).
Manufactures like Imec are confident they can use photographic techniques and flexible circuit board technology to create a multi-electrode arrays (MEA) that meet the density requirements set in the BAA. The tricky part here is to ensure the final system is biologically compatible.
I was planning on applying to the grant using an optical approach but got delayed by an industry contact / didn't have time to vet other optical technologies before the abstract submission deadline. CRISPR-CAS9 editing is already in human trials for Parkinson's patients so getting FDA approval to use optogentic techniques to control human brains for extreme cases illnesses like quadriplegia and ALS could be doable in 4 years. And while readout of 100,000 neurons using optical methods and seems doable via implantable sensors, using optics for precise writing to 1 million neurons didn't seem possible in a fully implantable device without overheating the brain tissue, although it might be possible using a though skull fiber-optic technology. In any case, it's clear more development work would be needed in an optical approach vs an MEA based one.
This sort of thing has always been available for pharmaceutical manufacturing, but has been long overlooked on the research side. I've been at a few science research based engineering companies that collect this kind of data already, but don't do anything to analyse it unless something catastrophic happens. A software tool that could enable visualization of this data across experiments will extremely valuable as we remove technician to technician variation (via robotics) and a synthetic biology becomes more common place, and could prove as invaluable as well plate edge effect analysis already included in major bio-analysis software packages such as spotfire.
This. +1 It's like people only read the summaries so that they can reply instead of read to inform themselves....
“Principal investigators (PIs) on an NIH grant must contact NIH through their institution to seek prior approval for a change of institution. NIH grants are made to institutions, not to individuals. When a PI moves to another institution, the original grantee institution frequently agrees to relinquish the grant to the PIs new institution but NIH must approve this transfer. If the original grantee institution does not wish to relinquish the grant, they must seek NIH approval to appoint a new PI to the grant. NIH must assess whether the project can continue under the new scientific leadership at the original institution, and if so will approve a change in PI. If not, the grant is terminated.”
Actually, if all of you would stop arguing and RTFA, you'd note that there is clarity about all of this: 'UCSD—not Aisen— “is contractually obligated by its agreements with the NIH and research partners to maintain and safeguard data from clinical studies conducted by ADCS. ”'
UCSD—not Aisen— “is contractually obligated by its agreements with the NIH and research partners to maintain and safeguard data from clinical studies conducted by ADCS. ”
Dew formation depends on dirty water. If you remove the impurities in the air, then your condensention efficiencies will go down: https://www.youtube.com/watch?...
Seems like a non-issue as there is plenty of room for them to adapt, shifting from away from collision to more detailed versions of comprehensive that will cover minor dings, regular wear and tear and battery replacement.
p>If you really want to "get money out of politics," you need to (as much as possible) get politics out of the economy. (Ideologues will always lobby, and that's fine, because it's the crony capitalism and pay-to-play aspects that are most objectionable.) Which, of course, is not what many reformers want to do. Until they do, they are basically advocating spreading sugar around their picnic blanket, and then complaining about all the ants.
Check out Laurence Lessig's speech "We the People, and the Republic we must reclaim" . The premise is that there is no way to even start getting politics out of the economy (or any other sensible legislation) until we remove money from politics.
The scientists that published that just must not be up on their literature or the author is just confused and the scientists are trying to talk up their research.
FTA: "A touchpad configuration module has been added" This is the one configuration took that has been missing from KDE since the upgrade from 3.5. The activities based power management is also a long awaited feature (turn off powersaving / sleep / hybernate when in presentation mode). Other than that the rest appears to be eye candy. Still waiting for automatic activity settings based on locally sensed wifi.... (I still need to manually change my external monitor setting every time I get into work / home).
When is the last time you negotiated prices at the grocery store?
Well since the Reddit is the one forking over the money, their proposed model doesn't match grocery shopping either: "When was the last time you got to the checkout register and refused to buy products until the merchant agreed to your pricing?"
Fuck Microsoft and fuck google. Why should they expect the public to fund a specialized skill set that makes them money.
Why should any employer want the school system to educate students to do anything useful? Heck, why are we funding education at all? By your argument, employers that want people to be able to keep books (add and subtract), or email (read and write) or treat patients (science) should be funding these things them selves. This is the same sort of BS circular logic people like to give as to why we shouldn't tax companies that depend on public infrastructure (since they just pass the costs onto customers anyway). Stop jerking your self off to Ann Rand and wake up!
I don't get it! If everyone (most people?) started using diceware and "there are [only] 60,466,176 different potential passphrases" wouldn't it be broken in less than a second if one can make "a trillion guesses a second"?
You must be trolling as google de-legitimized - they no longer require 'real name idiocy'....
And this was before the citizens united decision - just goes to show you that publicly funded elections are the only way to prevent this sort of thing from happening...
Doesn't matter. If it says "parsley", which does nothing, then the rule is it's supposed to be parsley and nothing but parsley.
THIS is exactly why I don't understand why there's even a debate about GMO labeling. Not that I'd waste my time fighting to add it to the labels as I care more about residual chemical levels than genes from another edible plant. Nonetheless, cloned in genes that were never part of the product before == adulterated product.
This project seems to have similar ambitions to the Justify project. Justify's creator has a good overview of Justify and has published some thoughts about why softwear like this is important.
If I were a mod, I won't know whether to mod you at Troll or Insightful: Your history lesson on Buchanan and Pierce vs Lincoln was enlightening, but you are totally overlooking the shit-stained victory that is ObamaCare - At this point there's no way the republican's can appeal it, it would cause a mass uprising now that people realize Obamacare isn't really going to kill grandma, and makes it easier to stay insured (COBRA was a ripoff) if your unemployment insurance runs out, or if you decide to become an consultant. ...and there's something to be said about a passing a law that not even the Kennedy's or Clinton's could.