Re:Rejection in classic transplants only possible?
on
3D Human Cells Grown
·
· Score: 2, Informative
The are actually different levels of immuno compatibility between different cells from different individuals . The "big red flags" of immnocompatibility are called the major histocompatibility complex (HMC's). Large differences in HMC genotypes pretty much ensures tissue rejection, called acute rejection. Twins and cloned tissue have identical MHC's, so this is why they are the prefered donors where possible. This is highest in the first 3 months after transplantation, and is lowered by immunosuppressive agents in maintenance therapy.
There are also a host of minor histocompatibility complexes, which can over time elicit at response called chronic rejection, or chronic allograft vasculopathy, which takes about a decade and leads to fibrosis of the vasculature of the new organ. The reasons why some patients end up in rejection while others seem to adapt is not fully understood.
Still, selling an emulator is asking for trouble. What are you making money off of? You are selling a software representation of the system vs. the hardware system. Which is cheaper? - So you are competition for the hardware platform.
This may not be true for the GBA, but most gaming companies do not make money on their hardware sales. Instead, the hardware is often sold as a loss leader in order to seed the market place with a particular platform. Most of the profits come from the licensing fees the platform provider charges developers to license their game on the platform. I think that what really bothers Nintendo here is the potential loss of those game licenses due to cart downloads.
Personally, I think that this is pretty shortsighted of them. If they could come up with some kind of a secure software distribution for their titles, emulators like this could massively increase their profit margins by allowing them to avoid the overhead cost of hardware sales and cart manufacturing.
The british Television Fee is not a fee for airwave use, but rather a fee for content service. The BBC channels in the UK are government run, and the budget to run the stations comes from from this fee.
Itâ(TM)s not the action itself that was illegal, but the end to which it was done.
The point of this article is not that it should be illegal to taught a feature and then not ship it, but rather that doing so with the intended effect of artificially manipulating the market is illegal (and always has been). Most of the time, I think that you can argue that the effect that these kinds of practices have on the market is negligible; the tech market is fairly savvy to the hype most people spew. The difference in the Enron case is that the market was so out of control with optimism that it failed to question anything. Enronâ(TM)s guilt is in manipulating that optimism.
The easiest way to validate these types of prediction mechanisms is to feed them only part of your data set and see how well it predicts your remaining dataset. For example, if you have an ocean temperature data set from 1920 to the present, you might start by feeding it 1920-1992 and seeing how well its predictions for then past ten years hold up to you actual data. You may think that the known data set it too small for accurate predictions, but there are some fascinating methods (like ice core sampling and tree growth sampling) that seem to allow pretty good deductions as to past climate conditions over a very long period of time.
He creates a problem for himself by not providing us with his raw data, making any subsequent verification of the trend difficult. In fact, the one data set he gives us: Phrase 3 mos 6 mos 12 mos. Total buy low sell high 4700 5470 6200 7830
60% 70% 79% 100% seems to demonstrate the opposite of the trend that he describes. Indeed, a current search on google shows about 1,270,000 results (makes you wonder when he did his searches that the current number of results is so many orders of magnitude in difference). The methodology also fails to take in to account any growth in the size of the web, which could mask the effects of decay.
No I have to go out and buy some new hardware I don't need so that the drivers take longer to load, so that I can finish my game of break out before the boot is over. Maybe I could just fragment my hard drive...
Clie PEG-S320 ($199 )
+ Nokia 3360 ($200)
+ $20/month ISP
+ ~$35/month Cellphone contract
+ ~$0.35/min data call fee(voicestream & cingular)
+ Cost of having to make extra calls to check for email becasue of no notification.
+ Cost of having to download full web pages since colutions like Blazer don't use a proxy to reduce data size the way that web clipping does.
+ Cost of having to wait 45 seconds (the avg time for PPP negotation over a GSM link) every time you want to do data
+ Cost of looking stupid trying to hold the IR port of your phone in line with the IR port of your PDA.
Total cost? Who knows. But I know that I don't usually use telnet on my pda, and most pda users dont even know what telnet is. Most people want good email access, and the ability to check a few key websites (remeber that the top 10 websites now account for something like 80% of peoples online time). The i705 gives me both thoose things in a single easy package.
In several of the shots, Amidala has her hair up in a very Leah like manner. This is kind of an interesting idea, since it is likely that Leah is Amidala's daughter...
Unless replay is going to keep some kind of centralized database of who is transmitting what to whom, it would be very hard to enforce a fifteen retansmit limit if a bunch of reasonably competent hackers decided to break it. In any protection scenario, you've got to have some trusted element in the equation. If you're putting the hardware into the hands of the public, it can't be considered trusted. Since users A and B can't be trusted, you would need some kind of an intermediary trusted element, like a decryption key server, to make sure shows couldn't be pirated.
"Senator Hollings, I'm afraid you have to come with us."
"What's this all about?"
"Your pacemaker sir, several people at the RIAA have complained that it doesn't meet SSSCA security standards. They're worried that you might try to use it to illegally copy MP3 files. It will have to be removed. "
The fact that MP3 is lossy is really not the point. JPG is lossy, and we seem to be okay with that. The simple fact is that a good bit of the data that is stored on a CD is either sonically redundant (.i.e. your ear will fill it in for itself) or unhearable (for most people). I propose a simple test for most people. Hi frequency sound is the most information rich, and therefor tends to suffer first when it is compressed. To choose a bit rate level (I use VBR with a 192 minimum), try encoding a sond at various bitrates and listening first for the quality of the drums, particuarlly hi spots like rim shots. If you can hear the difference in the drum track, your bit rate is probably too low. This should help you find a low end but rate you can be comfortable with.
I think the really interesting question here is will the suit seek to force SloMedia to remove their use of GPL'd code, or whether it will attemept to force them to open up their code.
"The GPL turns our existing concepts of intellectual property rights on their heads."
I love that M$ actually considers this an arguement.
I think that the real reason that Microsoft doesn't like GPL is clear. In the past, if a technology challenged Microsoft, they always had a back up for getting rid of it: Buy the technology (remember when they tired to buy Palm). But GPL takes way this option. once a technology is GPL'd, they can no longer just throw money at a technology and make it "go away".
One good point in all of this, GPL must reaaly be making M$ feel threatened for them to be spending all of this time trashing it.
-lowLark
back in the old school world of the printed page, when things moved at a sane enough pace that legal censorship could kill something overnight, there was a concept called fair use which protected the use of copyrighed materials under a number of circumstances, particularly for criticism, review, or parody. This is the same concept that has kept aolsucks alive. If reading the Banc of America web page in redneck doesn't count as parody, I don't know what does.
The Palm VII uses the Mobitex network administered in the US by bellsouth wireless data. Basically Mobitex and CDPD give about the same data rate (around 9600 is about right), but Mobitex in general has much better coverage, covering an estimated 90% of the US population vs. AT&T's 65%. Its true that the Palm VII the is not a true IP entity, the palm has whats called a MAN adress that identifies it on the network. You have to tunnel information through http, which is a bit wierd, but does save on network traffic overhead since the proxy compresses all the data. I've played with both devices and I have to say that my preference definately goes to the VII. It would be nice to be able to use any IP based applications, but I think that Palm has come out with a solution that fits the balance of functionailty and ease of use that has made palm a success. Not to mention the price differnece; $299 (palm V) + $399 (omnisky normal price, intro price is $299) = $698 vs. Palm VII's @ $499
"You and fifteen other strangers are marooned on a deserted tropical island in the South China Sea..." with only a camera crew, make-up artists and a production team to keep you company. Think about it, what your average person, even an attractive one, would look like after seven weeks in the jungle. CBS will obviously have to intervine in any number of cirumstances (what if someone decides "hell, Im on a desert island, I'll just walk around nude and fling excrament at the camera crew!!").
Slashdot Mirror
The are actually different levels of immuno compatibility between different cells from different individuals . The "big red flags" of immnocompatibility are called the major histocompatibility complex (HMC's). Large differences in HMC genotypes pretty much ensures tissue rejection, called acute rejection. Twins and cloned tissue have identical MHC's, so this is why they are the prefered donors where possible. This is highest in the first 3 months after transplantation, and is lowered by immunosuppressive agents in maintenance therapy. There are also a host of minor histocompatibility complexes, which can over time elicit at response called chronic rejection, or chronic allograft vasculopathy, which takes about a decade and leads to fibrosis of the vasculature of the new organ. The reasons why some patients end up in rejection while others seem to adapt is not fully understood.
This may not be true for the GBA, but most gaming companies do not make money on their hardware sales. Instead, the hardware is often sold as a loss leader in order to seed the market place with a particular platform. Most of the profits come from the licensing fees the platform provider charges developers to license their game on the platform. I think that what really bothers Nintendo here is the potential loss of those game licenses due to cart downloads.
Personally, I think that this is pretty shortsighted of them. If they could come up with some kind of a secure software distribution for their titles, emulators like this could massively increase their profit margins by allowing them to avoid the overhead cost of hardware sales and cart manufacturing.
The british Television Fee is not a fee for airwave use, but rather a fee for content service. The BBC channels in the UK are government run, and the budget to run the stations comes from from this fee.
Itâ(TM)s not the action itself that was illegal, but the end to which it was done.
The point of this article is not that it should be illegal to taught a feature and then not ship it, but rather that doing so with the intended effect of artificially manipulating the market is illegal (and always has been). Most of the time, I think that you can argue that the effect that these kinds of practices have on the market is negligible; the tech market is fairly savvy to the hype most people spew. The difference in the Enron case is that the market was so out of control with optimism that it failed to question anything. Enronâ(TM)s guilt is in manipulating that optimism.
Ive got an apple IIc sitting around, you want it?
It's yours if you want to pay the shipping (or pick it up in seattle).
email me at IIC.10.remmakjd@spamgourmet.com
and let me know.
-Dave
Really, I founds lots of numbers for the Kent Police department, though they do say to call 911...
. ht m
http://www.ci.kent.wa.us/Police/DeptInfo/phones
The easiest way to validate these types of prediction mechanisms is to feed them only part of your data set and see how well it predicts your remaining dataset. For example, if you have an ocean temperature data set from 1920 to the present, you might start by feeding it 1920-1992 and seeing how well its predictions for then past ten years hold up to you actual data. You may think that the known data set it too small for accurate predictions, but there are some fascinating methods (like ice core sampling and tree growth sampling) that seem to allow pretty good deductions as to past climate conditions over a very long period of time.
Good point, but the origional arguement still stands: that for the one set of data available, the trend seems to be towards growth rather than decay.
He creates a problem for himself by not providing us with his raw data, making any subsequent verification of the trend difficult. In fact, the one data set he gives us:
Phrase 3 mos 6 mos 12 mos. Total
buy low sell high 4700 5470 6200 7830
60% 70% 79% 100%
seems to demonstrate the opposite of the trend that he describes. Indeed, a current search on google shows about 1,270,000 results (makes you wonder when he did his searches that the current number of results is so many orders of magnitude in difference). The methodology also fails to take in to account any growth in the size of the web, which could mask the effects of decay.
No I have to go out and buy some new hardware I don't need so that the drivers take longer to load, so that I can finish my game of break out before the boot is over. Maybe I could just fragment my hard drive...
Clie PEG-S320 ($199 )
+ Nokia 3360 ($200)
+ $20/month ISP
+ ~$35/month Cellphone contract
+ ~$0.35/min data call fee(voicestream & cingular)
+ Cost of having to make extra calls to check for email becasue of no notification.
+ Cost of having to download full web pages since colutions like Blazer don't use a proxy to reduce data size the way that web clipping does.
+ Cost of having to wait 45 seconds (the avg time for PPP negotation over a GSM link) every time you want to do data
+ Cost of looking stupid trying to hold the IR port of your phone in line with the IR port of your PDA.
Total cost? Who knows. But I know that I don't usually use telnet on my pda, and most pda users dont even know what telnet is. Most people want good email access, and the ability to check a few key websites (remeber that the top 10 websites now account for something like 80% of peoples online time). The i705 gives me both thoose things in a single easy package.
In several of the shots, Amidala has her hair up in a very Leah like manner. This is kind of an interesting idea, since it is likely that Leah is Amidala's daughter...
Unless replay is going to keep some kind of centralized database of who is transmitting what to whom, it would be very hard to enforce a fifteen retansmit limit if a bunch of reasonably competent hackers decided to break it. In any protection scenario, you've got to have some trusted element in the equation. If you're putting the hardware into the hands of the public, it can't be considered trusted. Since users A and B can't be trusted, you would need some kind of an intermediary trusted element, like a decryption key server, to make sure shows couldn't be pirated.
"Senator Hollings, I'm afraid you have to come with us."
"What's this all about?"
"Your pacemaker sir, several people at the RIAA have complained that it doesn't meet SSSCA security standards. They're worried that you might try to use it to illegally copy MP3 files. It will have to be removed. "
The fact that MP3 is lossy is really not the point. JPG is lossy, and we seem to be okay with that. The simple fact is that a good bit of the data that is stored on a CD is either sonically redundant (.i.e. your ear will fill it in for itself) or unhearable (for most people). I propose a simple test for most people. Hi frequency sound is the most information rich, and therefor tends to suffer first when it is compressed. To choose a bit rate level (I use VBR with a 192 minimum), try encoding a sond at various bitrates and listening first for the quality of the drums, particuarlly hi spots like rim shots. If you can hear the difference in the drum track, your bit rate is probably too low. This should help you find a low end but rate you can be comfortable with.
I think the really interesting question here is will the suit seek to force SloMedia to remove their use of GPL'd code, or whether it will attemept to force them to open up their code.
"The GPL turns our existing concepts of intellectual property rights on their heads." I love that M$ actually considers this an arguement. I think that the real reason that Microsoft doesn't like GPL is clear. In the past, if a technology challenged Microsoft, they always had a back up for getting rid of it: Buy the technology (remember when they tired to buy Palm). But GPL takes way this option. once a technology is GPL'd, they can no longer just throw money at a technology and make it "go away". One good point in all of this, GPL must reaaly be making M$ feel threatened for them to be spending all of this time trashing it. -lowLark
back in the old school world of the printed page, when things moved at a sane enough pace that legal censorship could kill something overnight, there was a concept called fair use which protected the use of copyrighed materials under a number of circumstances, particularly for criticism, review, or parody. This is the same concept that has kept aolsucks alive. If reading the Banc of America web page in redneck doesn't count as parody, I don't know what does.
The Palm VII uses the Mobitex network administered in the US by bellsouth wireless data. Basically Mobitex and CDPD give about the same data rate (around 9600 is about right), but Mobitex in general has much better coverage, covering an estimated 90% of the US population vs. AT&T's 65%. Its true that the Palm VII the is not a true IP entity, the palm has whats called a MAN adress that identifies it on the network. You have to tunnel information through http, which is a bit wierd, but does save on network traffic overhead since the proxy compresses all the data. I've played with both devices and I have to say that my preference definately goes to the VII. It would be nice to be able to use any IP based applications, but I think that Palm has come out with a solution that fits the balance of functionailty and ease of use that has made palm a success. Not to mention the price differnece; $299 (palm V) + $399 (omnisky normal price, intro price is $299) = $698 vs. Palm VII's @ $499
"You and fifteen other strangers are marooned on a deserted tropical island in the South China Sea..." with only a camera crew, make-up artists and a production team to keep you company. Think about it, what your average person, even an attractive one, would look like after seven weeks in the jungle. CBS will obviously have to intervine in any number of cirumstances (what if someone decides "hell, Im on a desert island, I'll just walk around nude and fling excrament at the camera crew!!").