"It's like a Trojan horse," Baker explains. "Folate molecules on the nanoparticle bind to receptors on tumor cell membranes and the cell immediately internalizes it
According to that passage, it's not quite as simple as slipping through the cell membrane, like osmosis of water. It sounds like they're taking advantage of facilitated transport. Your cells need some molecules that are too large to fit through your cell membrane, so instead there are "gates" for them to pass through that are essentially proteins embedded in the membrane. Each gate can bond to a particular molecule, so you theoretically don't have stuff getting through that shouldn't. When the molecule bonds to the protein, it changes shape, taking the molecule in, typically without the expenditure of ATP (cell energy).
I'm curious, what exactly about this makes you feel uncomfortable?
The problem is he makes his money off of other people's work. Read the grandparent's link for more info. In a nutshell, he takes text and pictures from other sources and puts it on his own site, then links to it off slashdot instead of linking directly to the original sources.
Re:I LIVE for the Menus on DVDs
on
DivX 6.0 is Out
·
· Score: 2, Insightful
Now if you had a menu that disappeared after 10 seconds if you did nothing, that would be fine.
...with no sound. Replaying the same 10 seconds sound clip over and over again while you go make a sandwich drives me crazy.
Actually, I'd prefer they simply not come up at all, but still be on the disc. That way you can hit the menu button on your remote and go to whatever chapter you were on or find the special features (which are seldom worth watching, except on some Pixar films).
In addition to other people's concerns, I've seen spyware that kills taskman.exe everytime it starts. Checking like that is definitely a good habit, but beware its shortcomings.
I'm not quite sure what you're saying, partially because I think you're confusing who wrote the game and who published it. The game is by Bungie Software. Microsoft is that big company in Redmond that builds the X-box. Keeping Microsoft away from the project would probably help keep the game consistent with the original storyline, which apparently you have "heard" about but not experienced.
I personally think it's a great storyline and turns a game with already fun gameplay into an awesome experience.
I've found outages refreshing except when the weather sucks. A couple years ago, I was living on campus during Christmas break, so everyone else had gone home. Portland had a big ice storm, and since Portland isn't equipped to deal with rarities like that, doing stuff around town wasn't a good idea for several days. Comcast was being Comcast and was already 2 months behind schedule hooking up the campus with cable service after the old provider went under, so all I had was the local channels, which had cancelled most of the regular programming for "Winter Storm Watch," which was completely redundant after about an hour. Then the brand new Netscreen firewall, which we had literally installed 3 days before, loses a power supply. Nowhere to go, no TV, nobody around, library is closed, and NO INTERNET. After walking to Fred Meyers and back half a dozen times, I ended up borrowing a shovel from the grounds crew and clearing sidewalks until my hands bled, I was so bored.
Momentum would be gained as the climber ascended. Obviously, due to Coriolus effect, the climber would start to pull the cable in opposite direction of the earth's rotation. The cable would then be at an angle and pulling with a horizontal force component that would accellerate the climber tangentially, which is where it gets it's momentum. The object you want to release would have a significantly high tangential velocity to escape the earth's gravity. Once the downward tug of the the cable was released, the object would continue in an essentially straight line, while the cable pulled the counterweight as it had before, in a circle around the earth.
I hadn't heard the pinwheel idea before, but it would be more susceptible to that pesky momentum problem you pointed out, since there is no solid anchor like a sea platform. I think you would still need a pretty strong cable, since it still has to support it's own weight plus the weight of the payload. Plus aerodynamic drag would be an issue.
Maybe a more practical idea is to build a pinwheel in a lower orbit (still cheaper to reach than geosynchronous). It could consist of counterotating masses (like the Russian Bear bomber's propellers and some boats), two in each rotational plane to produce a moment couple. It would not be spinning while you load the payload. Then solar or nuclear powered electric motors would start the masses counter-rotating (necessary to provide the torque) over an extended period of time. This would add momentum without, if my head is working right at the moment, changing the orbit. Then you simply let go. Of course, you would need to find safe trajectories for 4 objects instead of 1.
Nope. Let's look at this idea (somebody please check my numbers).
If it broke below the load, the load would drift off into the space, because the counterweight in space would be exerting a tension on the ribbon. If it broke off above the load and the load was below geosynchronous orbit altitude, it would plummet. Let's assume the lifter falls from 10100 miles up, so that it falls 10,000 miles (about 16,000,000 meters) to the generally accepted boundary of space. Air resistance is then negligible, but we have enough ribbon to wrap nearly half way around the world. g = 10 m/s^2 (approx)We'll use the energy method to find it's entry velocity.
mgh = 0.5 * mv^2 gives us:
v = (2gh)^0.5 = 17,900 m/s = 40,000 miles/hour.
The shuttle orbits at 17,000 mph. We'll assume the carbon it's toast, but how long does the lifter take to fall and where does it land?
entry time: s = s(0) + v(0) + 0.5 t^2 gives:
t = (2*s/a)^0.5 = 1788 seconds
You can play with circles a bit, knowing that the earth takes 24 hours to rotate and that the radius of orbit is 22,400 km (16000 altitude + 6400 earth's radius) and find that the tangential velocity is 1630 m/s. This drops anything that doesn't burn up about 3000 kilometers downrange. Ok, that might be worth worrying about, but we're still talking about something smaller than an airliner, and it's mostly burnt up already. The danger is no more than we already face with planes over our head that can fall out of the sky, be bombed, or shot down. If it dropped from much lower than 10,000 miles, it wouldn't even make it to the coast.
If a significant amount of cable did somehow manage to reach the ground intact, you simply cut it up and clear it out of the way. Anyone who's worked with carbon fiber knows you can cut sheets of it with a good pair of scissors. Carbon nano-tubes are stronger than carbon fiber, but stress concentrations are a remarkable thing. The same concept is applied to cutting diamonds.
There has been concerns raised about what the health risks of exposure to carbon-nanotubes are, but I can't think of how a large amount of these things would be released in proximity to humans when the platform is anchored in the middle of the equatorial Pacific Ocean. I couldn't imagine someone crashing an airplane into the ribbon, for example, releasing more than a couple pounds.
I understand now. Still, the percent change in temperature is pretty much meaningless. If the processor can run safely at 100C or it experiences damage at 20C, that tells us nothing.
Remember in H.G. Wells's The War of the Worlds how our germs were Earth's last best defense against the invading Martians? Good to know we're developing a first-strike capability...
So you're suggesting that NASA has discovered oil on Mars!
Actually, temperature difference in Celsius is just as legitimate as temperature difference in Kelvin. What's the Celsius temperature difference between 27 C and 32 C? 5 degrees. How about 300 K and 305 K? Yep, 5 Kelvin. Remember that temperature difference is the driving factor in heat transfer. (Convective cooling: Q = hA(T2 - T1)). Thermodynamics is where absolute temperature is important.
Assuming that the ambient temperature was 22 C, then their control temperature of 33.5 C was 11.5 degrees higher. At 800 MHz, with a temperature of 26.9 C, the difference was 4.9 degrees. That's a 57% drop in temperature difference.
The flaw that catches my attention is that they never discussed what a reasonable temperature was to operate at. The temperature at the base of that monsterous heat sink was listed at a maximum of 33.5 C, which is about 90 F. That seems a little low, but perhaps their thermocouple was off or not in proper contact. If it really was 90 F, I would think they would have no problem running the computer with just their super heat sink. That's not even body temperature.
I'm more impressed by the fact that he actually makes the first post on Mars stories so consistently.
I suppose the informative rating is from those genuinely interested in finding out what happens next. We're talking about the future of the human race here people! At any rate, it's better than 75% of the other comments.
You have to admit, his story gets better each time, though. This time we make it all the way to death row! 4 or 5 more articles and we'll have a full fledged nuclear war, just from buying an X-box.
Seriously, though. Any insight on why the heck he keeps doing this?
I literally just started downloaded the 2nd iso for 3.0r5 from the USC mirror. I took a second to admire my 580 kB/s download speed, then thought, "Hey, I'm gonna go see if there's anything interesting on Slashdot." Creepy...
Despite the dripping sarcasm it actually is a decent article and starts off with a clear explanation of socket designations.
Granted, I may be the only person on slashdot primarily for the science articles, and therefore the only person who didn't know that stuff, but at least I've heard of AMD and that linus thingy...
Except that very few non-techies realize that.com means commercial. Most of the people I know think.com is "the big part" of the internet and everything else is the poor schmucks who were too slow to get the name they wanted. I'll bet they're smart enough to figure out what.xxx means, though.
Very well said. I agree 100%, although I am one of the brainwashed sheep who supposedly can't think for myself.
Blocking access to the hosts file would hardly even be necessary unless this became a common tactic. I seriously doubt very many teens would have a clue that the hosts file even exists or what it does, much less check it to see why their *.xxx isn't getting found.
Well perhaps because as a general principle, it's immoral to charge different amount for different fields of endeavor. A domain should cost the same, regardless of the TLD in which it resides.
Says who? I can think of lots of cases where different endeavors cost different amounts. Take parking. I can park right next to the Duncan Plaza for $8 for four hours. Or I can park in the garage 2 blocks away for $0.95/hour. One is closer to where I'm going..xxx specifies more closely the content than.com,.net, or.org.
It's also not without precedence. Check out the price of.jp,.cn,.tv, or quite a few other TLD's. Perhaps you would be better to consider the extra revenue as incentive to ICANN to create this additional service for its customers. Nobody is forcing them to buy it and nobody is forcing ICANN to create additional TLD's to administer.
You're thinking of robots.txt. You put it in the root of your domain and it specifies to the googlebot and most legitimate spiders not to crawl particular files (or all files) on the domain.
You and the grandparent are right, though. Few blog writers would add that in because they like to type their name into Google and see it come up on the first page of results. Of course, most would have no clue how to do it in the first place, so if blogger, livejournal, etc all created that file by default, it would be solved...
...Or we could just have a.blog TLD, then they could get their glory on the search engines and we could filter them them.
Sanitize is a poor example of bloat. As far as I can tell, it's basically a shortcut to the already existing button in Tools > Options > Privacy that lets you "Delete all information stored while browsing." It does let you specifically select what information you clear, though.
I never cared about it, so I never read up on it. Was this genuinely a bug, or was it the result of Slashdot's messed up, almost 3.2 compliant coding? It would seem dumb to fix a bug in page by modifying the browser, even if it is slashdot.
Here's my report on using it. I downloaded Deer Park last night. I am using it now, and it's been working fine so far. I did have one page (Mount St. Helen's Volcano Cam) display as code rather than rendering, but that's been the only problem so far. I figure I'll mess around a bit and try to figure out the source of the problem before I submit a bug report.
Slashdot Mirror
I'm curious, what exactly about this makes you feel uncomfortable?
No, kilosloppy = sloppy * 2^10. If I had a penny for every person who has doesn't can't remember that...
The problem is he makes his money off of other people's work. Read the grandparent's link for more info. In a nutshell, he takes text and pictures from other sources and puts it on his own site, then links to it off slashdot instead of linking directly to the original sources.
Actually, I'd prefer they simply not come up at all, but still be on the disc. That way you can hit the menu button on your remote and go to whatever chapter you were on or find the special features (which are seldom worth watching, except on some Pixar films).
In addition to other people's concerns, I've seen spyware that kills taskman.exe everytime it starts. Checking like that is definitely a good habit, but beware its shortcomings.
I'm not quite sure what you're saying, partially because I think you're confusing who wrote the game and who published it. The game is by Bungie Software. Microsoft is that big company in Redmond that builds the X-box. Keeping Microsoft away from the project would probably help keep the game consistent with the original storyline, which apparently you have "heard" about but not experienced.
I personally think it's a great storyline and turns a game with already fun gameplay into an awesome experience.
I think we solved his spam problem for today.
I've found outages refreshing except when the weather sucks. A couple years ago, I was living on campus during Christmas break, so everyone else had gone home. Portland had a big ice storm, and since Portland isn't equipped to deal with rarities like that, doing stuff around town wasn't a good idea for several days. Comcast was being Comcast and was already 2 months behind schedule hooking up the campus with cable service after the old provider went under, so all I had was the local channels, which had cancelled most of the regular programming for "Winter Storm Watch," which was completely redundant after about an hour. Then the brand new Netscreen firewall, which we had literally installed 3 days before, loses a power supply. Nowhere to go, no TV, nobody around, library is closed, and NO INTERNET. After walking to Fred Meyers and back half a dozen times, I ended up borrowing a shovel from the grounds crew and clearing sidewalks until my hands bled, I was so bored.
Momentum would be gained as the climber ascended. Obviously, due to Coriolus effect, the climber would start to pull the cable in opposite direction of the earth's rotation. The cable would then be at an angle and pulling with a horizontal force component that would accellerate the climber tangentially, which is where it gets it's momentum. The object you want to release would have a significantly high tangential velocity to escape the earth's gravity. Once the downward tug of the the cable was released, the object would continue in an essentially straight line, while the cable pulled the counterweight as it had before, in a circle around the earth.
I hadn't heard the pinwheel idea before, but it would be more susceptible to that pesky momentum problem you pointed out, since there is no solid anchor like a sea platform. I think you would still need a pretty strong cable, since it still has to support it's own weight plus the weight of the payload. Plus aerodynamic drag would be an issue.
Maybe a more practical idea is to build a pinwheel in a lower orbit (still cheaper to reach than geosynchronous). It could consist of counterotating masses (like the Russian Bear bomber's propellers and some boats), two in each rotational plane to produce a moment couple. It would not be spinning while you load the payload. Then solar or nuclear powered electric motors would start the masses counter-rotating (necessary to provide the torque) over an extended period of time. This would add momentum without, if my head is working right at the moment, changing the orbit. Then you simply let go. Of course, you would need to find safe trajectories for 4 objects instead of 1.
Nope. Let's look at this idea (somebody please check my numbers).
If it broke below the load, the load would drift off into the space, because the counterweight in space would be exerting a tension on the ribbon. If it broke off above the load and the load was below geosynchronous orbit altitude, it would plummet. Let's assume the lifter falls from 10100 miles up, so that it falls 10,000 miles (about 16,000,000 meters) to the generally accepted boundary of space. Air resistance is then negligible, but we have enough ribbon to wrap nearly half way around the world. g = 10 m/s^2 (approx)We'll use the energy method to find it's entry velocity.
mgh = 0.5 * mv^2 gives us:
v = (2gh)^0.5 = 17,900 m/s = 40,000 miles/hour.
The shuttle orbits at 17,000 mph. We'll assume the carbon it's toast, but how long does the lifter take to fall and where does it land?
entry time: s = s(0) + v(0) + 0.5 t^2 gives:
t = (2*s/a)^0.5 = 1788 seconds
You can play with circles a bit, knowing that the earth takes 24 hours to rotate and that the radius of orbit is 22,400 km (16000 altitude + 6400 earth's radius) and find that the tangential velocity is 1630 m/s. This drops anything that doesn't burn up about 3000 kilometers downrange. Ok, that might be worth worrying about, but we're still talking about something smaller than an airliner, and it's mostly burnt up already. The danger is no more than we already face with planes over our head that can fall out of the sky, be bombed, or shot down. If it dropped from much lower than 10,000 miles, it wouldn't even make it to the coast.
If a significant amount of cable did somehow manage to reach the ground intact, you simply cut it up and clear it out of the way. Anyone who's worked with carbon fiber knows you can cut sheets of it with a good pair of scissors. Carbon nano-tubes are stronger than carbon fiber, but stress concentrations are a remarkable thing. The same concept is applied to cutting diamonds.
There has been concerns raised about what the health risks of exposure to carbon-nanotubes are, but I can't think of how a large amount of these things would be released in proximity to humans when the platform is anchored in the middle of the equatorial Pacific Ocean. I couldn't imagine someone crashing an airplane into the ribbon, for example, releasing more than a couple pounds.
I understand now. Still, the percent change in temperature is pretty much meaningless. If the processor can run safely at 100C or it experiences damage at 20C, that tells us nothing.
Actually, temperature difference in Celsius is just as legitimate as temperature difference in Kelvin. What's the Celsius temperature difference between 27 C and 32 C? 5 degrees. How about 300 K and 305 K? Yep, 5 Kelvin. Remember that temperature difference is the driving factor in heat transfer. (Convective cooling: Q = hA(T2 - T1)). Thermodynamics is where absolute temperature is important.
Assuming that the ambient temperature was 22 C, then their control temperature of 33.5 C was 11.5 degrees higher. At 800 MHz, with a temperature of 26.9 C, the difference was 4.9 degrees. That's a 57% drop in temperature difference.
The flaw that catches my attention is that they never discussed what a reasonable temperature was to operate at. The temperature at the base of that monsterous heat sink was listed at a maximum of 33.5 C, which is about 90 F. That seems a little low, but perhaps their thermocouple was off or not in proper contact. If it really was 90 F, I would think they would have no problem running the computer with just their super heat sink. That's not even body temperature.
I'm more impressed by the fact that he actually makes the first post on Mars stories so consistently.
I suppose the informative rating is from those genuinely interested in finding out what happens next. We're talking about the future of the human race here people! At any rate, it's better than 75% of the other comments.
You have to admit, his story gets better each time, though. This time we make it all the way to death row! 4 or 5 more articles and we'll have a full fledged nuclear war, just from buying an X-box.
Seriously, though. Any insight on why the heck he keeps doing this?
Whoa...I'm hearing twilight zone music.
I literally just started downloaded the 2nd iso for 3.0r5 from the USC mirror. I took a second to admire my 580 kB/s download speed, then thought, "Hey, I'm gonna go see if there's anything interesting on Slashdot." Creepy...
Despite the dripping sarcasm it actually is a decent article and starts off with a clear explanation of socket designations.
Granted, I may be the only person on slashdot primarily for the science articles, and therefore the only person who didn't know that stuff, but at least I've heard of AMD and that linus thingy...
Except that very few non-techies realize that .com means commercial. Most of the people I know think .com is "the big part" of the internet and everything else is the poor schmucks who were too slow to get the name they wanted. I'll bet they're smart enough to figure out what .xxx means, though.
Very well said. I agree 100%, although I am one of the brainwashed sheep who supposedly can't think for myself.
Blocking access to the hosts file would hardly even be necessary unless this became a common tactic. I seriously doubt very many teens would have a clue that the hosts file even exists or what it does, much less check it to see why their *.xxx isn't getting found.
It's also not without precedence. Check out the price of
You're thinking of robots.txt. You put it in the root of your domain and it specifies to the googlebot and most legitimate spiders not to crawl particular files (or all files) on the domain.
...Or we could just have a .blog TLD, then they could get their glory on the search engines and we could filter them them.
You and the grandparent are right, though. Few blog writers would add that in because they like to type their name into Google and see it come up on the first page of results. Of course, most would have no clue how to do it in the first place, so if blogger, livejournal, etc all created that file by default, it would be solved...
Sanitize is a poor example of bloat. As far as I can tell, it's basically a shortcut to the already existing button in Tools > Options > Privacy that lets you "Delete all information stored while browsing." It does let you specifically select what information you clear, though.
I never cared about it, so I never read up on it. Was this genuinely a bug, or was it the result of Slashdot's messed up, almost 3.2 compliant coding? It would seem dumb to fix a bug in page by modifying the browser, even if it is slashdot.
Here's my report on using it. I downloaded Deer Park last night. I am using it now, and it's been working fine so far. I did have one page (Mount St. Helen's Volcano Cam) display as code rather than rendering, but that's been the only problem so far. I figure I'll mess around a bit and try to figure out the source of the problem before I submit a bug report.
Good clarification. Thanks. I started to figure that out from the other replies, but neither of them said it very well.