I've been to Soviet Russia (Stalingrad (now St. Petersberg)) and lived in it personally, first hand.` Have you? I agree with the poster who said he'd take free market capitalism over socialism ANY DAY.
And I having been to Leningrad (now St. PetersbUrg) call bullshit on your post. Not only you haven't lived there but you are off by 1000 miles in your geography. I also doubt that you are old enough to have actually lived in Stalingrad and being able to tell about it on Slashdot. Stalingrad was renamed to Volgograd back in 1961. You can say anything about USSR, but they made damn sure they taught their geography and history at school. There is no way for somebody who has lived in USSR to mix Leningrad with Stalingrad. So stop trolling please.
Nah, the slave ship schematics here and here show all "passengers" facing the same direction. It seems the current state of the art in passenger comfort of the aviation industry is at the level of your average slave ship.
Alternating orientation of the passengers, with no space for movement. I guess somebody with engineering degree has been paying attention to the cartoons section of The New Yorker/a>
I like to read Derek Lowe's blog "In the pipeline". It has good insights on the pharma industry, drug development, etc. If you go there be sure to check the "Things I won't work with" page. It makes for some very entertaining reading on "exciting" (as in "oh my god we all gonna die") chemical substances.
When was the last time you've ever heard of a dogfight?
In pretty much every war every war where both opponents had air capability, including the first Gulf war and the Balkan war. In the first Gulf war air-to-air combat usually happened after the pilots could get visual confirmation that the target is not a friendly. If you are in visual range you are pretty much in a dog fight. Pierre Sprey, the man who brought us the F16 and the A10, has the best description of the F-35:
If you read the article, you will notice that the F-35 failed a test that was stacked in its favor - The F-35 did not carry any load, while the F16 was saddled with two external tanks.
How exactly is "1-map out everything and figure out what/how everything works, so there are no unexpected results." different from "2-try stuff out and see what happens."? Is far as I know the way we "figure how something works" is to "try stuff out and see what happens". We do this with lab animals and then try as best as we can to show that the animal model is a good approximation to the human. If this is the case we can assume that we whatever "stuff" we tried on the animal will work the same way in humans without doing human experimentation. You can also "experiment" on humans without being unethical. That's why we study human disease. In this case the some random "stuff" has been already broken by nature and we can see the consequences. What is left to us is to figure out what the "stuff" is.
And by "two" you mean "three". The two mechanisms dealing with this type of damage in human cells are Nucleotide Excision Repair and Trans-Lesion Synthesis. There are multiple published works showing that the resistance of human cells to UV radiation increases when they are made to express photolyase. Doesn't matter if one mechanism is better than the other as long as having two (or three) does a better job than one.
Yeah, but we can do better than random modifications if we have a solid understanding of ourselves.
Can you do better? May be you could in the simplest of cases, where we know that the gene variant in another organism works better than the variant we have. Even in such cases you will need to brace yourself for the unexpected consequences. The number of nonlinear interactions between different genes, and between genes and the environment makes it very hard to predict outcomes. There is a virtue in having a population with buggy, unstable and diverse genomes. If the environment changes, and it alwys does, the population as a whole has a better chance of surviving the changes, compared to a population with stable and uniform genomes.
Having said that here is the number one on my list for bettering the human genome:DNA Photolyase, an enzyme that directly repairs the most common type of DNA damage caused by UV light. For reasons that are poorly understood most mammals, including humans lack this enzyme. The health benefit is obvious - a photolyase will reduce the incidence of skin cancer.
Re:I thought this was already banned
on
FDA Bans Trans Fat
·
· Score: 4, Interesting
In the past few years, I don't recall coming across a single product that had any trans fat.
FDA had mandatory labeling for transfats, which contained a loophole. You could put a label stating "0g transfat" if your product contains less than 0.5g of transfat per serving. If you define your serving size as 1g than your product can be made of nearly 50% transfats. Many bakery products, particularly the ones with long shelf life do contain transfats and can be labeled as "0g transfat". That's why some manufacturers use a label "No transfats" to indicate that there are indeed no transfats in their product.
Yeah, in the tropics it very well may be better. Move somewhere cold and every bit of steam that escapes almost instantaneously turns into ice. If you want to park your aircraft carrier in the Bering's see or further north, the steam catapults will turn into nightmares.
How is this physically possible? 1000 transplants in under three years! This is more than one serious microsurgery per day. An article in WSJ says he leaves the brain stem of the acceptor along with the so that it can control breading and hearth beat. This would mean that he is just connecting the blood vessels of the donor head to the circulatory system on the acceptor, without connecting the nerves. This seems more feasible to me, but hardly warrants the bombastic headlines. Does anybody have a link to an original research paper?
You don't need the latest and the greatest tech to have an outstanding house in US. You probably don't want to put in something that has not been thoroughly tested into a structure that is designed to serve for decades. I would recommend looking into some of the technologies involved in building passive houses (think insulation, double pane windows). And before picking on whatever the coolest fad in wiring there is, make sure you put all your wiring in pipes. This way whenever you decide you need to upgrade your GigE to Fiber, or whatever comes out next month you don't need to destroy half of your house.
Because Google pays billions to Apple to make its search engine the default search provider for iOS devices, the company collects much more from ads placed on Apple devices than from ads on Android devices.
Google pays apple to be default search engine on iOS; Google does not pay Google to be the default search engine on Android --> Google (the one that doesn't get paid by Google) must be such a looser. Once we have proven that we bravely conclude:
If Google already makes more from ads on iOS than Android, growth in iOS might actually be good for Google's bottom line.
And you can provide testable evidence to support your statement?? I don't thin so, but than again its me trying to reason with yet another conspiracy theory nuthead.
Whoever put together their web site forgot the tag. Otherwise it is hard to explain how a site calling itself "Reason" so blatantly demonstrates complete lack of the stuff.
First of all, this is an amazing study.
How surprising is that we can live without certain genes? Not that surprising. We have done numerous experiments where we have knocked out genes in mice and other organisms and they do just fine. There is no reason why it should be any different in humans.
Keep in mind that these variations in the sequence are predicted to disable the gene, but not verified to do so. For example variants that introduce stop codons in the middle of a gene are typically predicted to disable the gene. However this is not always the case. Sometimes the piece of the gene that has the stop codon gets spliced out and the gene can still produce a functional albeit shorter protein. What is needed now is some experimental evidence showing what fraction of these genes are fully disabled.
I second this. Put 50% of any political contribution into a fund and then distribute it to those who vote. That will raise voter participation and reduce the influence of money in politics.
Pass mandatory voting law, and you can be guaranteed that nobody who voted for the law in congress will ever be reelected again. This could be fresh start.
How about you read the entire article and not quote selectively. One major issue is the raw data from clinical studies. In these studies the data identifying the patients is protected to preserve the privacy. The reason for this is that publishing data that identifies the subjects of the study will deter participation, particularly from people with severe conditions. This will ultimately bias the results and will make the studies irrelevant. There is also the existing legislation protecting the patient privacy which prohibits publishing personally identifiable information without explicit consent from the patients. The law that is being proposed will make it impossible to use epidemiological data from medical records.
It is pretty obvious that the goal of this legislature is not to enforce "common sense". The goal is to make EPA powerless by preventing it from backing its decisions with real data. The most telling part is that the legislature will quote: "bar academic scientists on the panels from talking about matters related to research they’re doing." WTF? How is EPA supposed to make decisions? By ignoring the advice of scientist who work on the matter and taking advice from people who are completely clueless?
Slashdot Mirror
I've been to Soviet Russia (Stalingrad (now St. Petersberg)) and lived in it personally, first hand.` Have you? I agree with the poster who said he'd take free market capitalism over socialism ANY DAY.
And I having been to Leningrad (now St. PetersbUrg) call bullshit on your post. Not only you haven't lived there but you are off by 1000 miles in your geography. I also doubt that you are old enough to have actually lived in Stalingrad and being able to tell about it on Slashdot. Stalingrad was renamed to Volgograd back in 1961. You can say anything about USSR, but they made damn sure they taught their geography and history at school. There is no way for somebody who has lived in USSR to mix Leningrad with Stalingrad. So stop trolling please.
Nah, the slave ship schematics here and here show all "passengers" facing the same direction. It seems the current state of the art in passenger comfort of the aviation industry is at the level of your average slave ship.
Alternating orientation of the passengers, with no space for movement. I guess somebody with engineering degree has been paying attention to the cartoons section of The New Yorker/a>
I like to read Derek Lowe's blog "In the pipeline". It has good insights on the pharma industry, drug development, etc. If you go there be sure to check the "Things I won't work with" page. It makes for some very entertaining reading on "exciting" (as in "oh my god we all gonna die") chemical substances.
I am sure they will, bur first you need to upgrade to "coach plus/minus"
One more thing. You need the capability to turn, not only to dog-fight, but also to avoid missiles.
When was the last time you've ever heard of a dogfight?
In pretty much every war every war where both opponents had air capability, including the first Gulf war and the Balkan war. In the first Gulf war air-to-air combat usually happened after the pilots could get visual confirmation that the target is not a friendly. If you are in visual range you are pretty much in a dog fight. Pierre Sprey, the man who brought us the F16 and the A10, has the best description of the F-35:
"A turkey. Cannot run, cannot hide and cannot fight"
If you read the article, you will notice that the F-35 failed a test that was stacked in its favor - The F-35 did not carry any load, while the F16 was saddled with two external tanks.
How exactly is "1-map out everything and figure out what/how everything works, so there are no unexpected results." different from "2-try stuff out and see what happens."? Is far as I know the way we "figure how something works" is to "try stuff out and see what happens". We do this with lab animals and then try as best as we can to show that the animal model is a good approximation to the human. If this is the case we can assume that we whatever "stuff" we tried on the animal will work the same way in humans without doing human experimentation. You can also "experiment" on humans without being unethical. That's why we study human disease. In this case the some random "stuff" has been already broken by nature and we can see the consequences. What is left to us is to figure out what the "stuff" is.
So you'd then have two repair mechanisms.
And by "two" you mean "three". The two mechanisms dealing with this type of damage in human cells are Nucleotide Excision Repair and Trans-Lesion Synthesis. There are multiple published works showing that the resistance of human cells to UV radiation increases when they are made to express photolyase. Doesn't matter if one mechanism is better than the other as long as having two (or three) does a better job than one.
Yeah, but we can do better than random modifications if we have a solid understanding of ourselves.
Can you do better? May be you could in the simplest of cases, where we know that the gene variant in another organism works better than the variant we have. Even in such cases you will need to brace yourself for the unexpected consequences. The number of nonlinear interactions between different genes, and between genes and the environment makes it very hard to predict outcomes. There is a virtue in having a population with buggy, unstable and diverse genomes. If the environment changes, and it alwys does, the population as a whole has a better chance of surviving the changes, compared to a population with stable and uniform genomes.
Having said that here is the number one on my list for bettering the human genome:DNA Photolyase, an enzyme that directly repairs the most common type of DNA damage caused by UV light. For reasons that are poorly understood most mammals, including humans lack this enzyme. The health benefit is obvious - a photolyase will reduce the incidence of skin cancer.
In the past few years, I don't recall coming across a single product that had any trans fat.
FDA had mandatory labeling for transfats, which contained a loophole. You could put a label stating "0g transfat" if your product contains less than 0.5g of transfat per serving. If you define your serving size as 1g than your product can be made of nearly 50% transfats. Many bakery products, particularly the ones with long shelf life do contain transfats and can be labeled as "0g transfat". That's why some manufacturers use a label "No transfats" to indicate that there are indeed no transfats in their product.
Yeah, in the tropics it very well may be better. Move somewhere cold and every bit of steam that escapes almost instantaneously turns into ice. If you want to park your aircraft carrier in the Bering's see or further north, the steam catapults will turn into nightmares.
How is this physically possible? 1000 transplants in under three years! This is more than one serious microsurgery per day. An article in WSJ says he leaves the brain stem of the acceptor along with the so that it can control breading and hearth beat. This would mean that he is just connecting the blood vessels of the donor head to the circulatory system on the acceptor, without connecting the nerves. This seems more feasible to me, but hardly warrants the bombastic headlines. Does anybody have a link to an original research paper?
They were pretty good for collisions 15 years ago
There fixed that for you
What makes you think your tootbrush has less germs than your toilet?
You don't need the latest and the greatest tech to have an outstanding house in US. You probably don't want to put in something that has not been thoroughly tested into a structure that is designed to serve for decades. I would recommend looking into some of the technologies involved in building passive houses (think insulation, double pane windows). And before picking on whatever the coolest fad in wiring there is, make sure you put all your wiring in pipes. This way whenever you decide you need to upgrade your GigE to Fiber, or whatever comes out next month you don't need to destroy half of your house.
Because Google pays billions to Apple to make its search engine the default search provider for iOS devices, the company collects much more from ads placed on Apple devices than from ads on Android devices.
Google pays apple to be default search engine on iOS; Google does not pay Google to be the default search engine on Android --> Google (the one that doesn't get paid by Google) must be such a looser. Once we have proven that we bravely conclude:
If Google already makes more from ads on iOS than Android, growth in iOS might actually be good for Google's bottom line.
Is this an MBA degree speaking here?
Some of you may have reservations about the use of live concrete. Don't worry, just give it some time. It will grow on you.
And you can provide testable evidence to support your statement?? I don't thin so, but than again its me trying to reason with yet another conspiracy theory nuthead.
May be he is not a dingo after all.
Whoever put together their web site forgot the tag. Otherwise it is hard to explain how a site calling itself "Reason" so blatantly demonstrates complete lack of the stuff.
First of all, this is an amazing study. How surprising is that we can live without certain genes? Not that surprising. We have done numerous experiments where we have knocked out genes in mice and other organisms and they do just fine. There is no reason why it should be any different in humans. Keep in mind that these variations in the sequence are predicted to disable the gene, but not verified to do so. For example variants that introduce stop codons in the middle of a gene are typically predicted to disable the gene. However this is not always the case. Sometimes the piece of the gene that has the stop codon gets spliced out and the gene can still produce a functional albeit shorter protein. What is needed now is some experimental evidence showing what fraction of these genes are fully disabled.
I second this. Put 50% of any political contribution into a fund and then distribute it to those who vote. That will raise voter participation and reduce the influence of money in politics.
Pass mandatory voting law, and you can be guaranteed that nobody who voted for the law in congress will ever be reelected again. This could be fresh start.
How about you read the entire article and not quote selectively. One major issue is the raw data from clinical studies. In these studies the data identifying the patients is protected to preserve the privacy. The reason for this is that publishing data that identifies the subjects of the study will deter participation, particularly from people with severe conditions. This will ultimately bias the results and will make the studies irrelevant. There is also the existing legislation protecting the patient privacy which prohibits publishing personally identifiable information without explicit consent from the patients. The law that is being proposed will make it impossible to use epidemiological data from medical records. It is pretty obvious that the goal of this legislature is not to enforce "common sense". The goal is to make EPA powerless by preventing it from backing its decisions with real data. The most telling part is that the legislature will quote: "bar academic scientists on the panels from talking about matters related to research they’re doing." WTF? How is EPA supposed to make decisions? By ignoring the advice of scientist who work on the matter and taking advice from people who are completely clueless?