Wow. Those genetically modified mice "tga20 transgenic mice overexpressing PrPC" bred to be hyper-susceptible seem to be highly susceptible. After 15+ years of this "ice 9" business I'm still waiting for results that in any way meet Koch's Postulates. Oh yeah, let's stop calling this protein "prion" and start calling it a proteinaceous "toxin" which is what it is. Moreover, since this Nobel Prize winning hypothesis in no way seems to conform with the reality of widely spreading communicable encephalitis in sheep, beef and mule deer why not entertain the notion that this is a slow virus and that the symptomatic misfolded protein is a mere phenotype, possibly detrimental, but not causal. Oh yeah, figuring this out would mean working with big smelly farm animals and we prion people don't like to get dirty. Meanwhile Laura Manuelidis is fighting the good fight against overwhelming odds. http://en.wikipedia.org/wiki/Laura_Manuelidis
But what about Good Google? How much carbon is saved each year, for example, by their handy maps? (Now if I could only get my wife to stop printing them out and just write the directions on a piece of waste paper) How much does Google reduce carbon by efficiently locating points of interest -- and someday -- helping you get your car to the nearest electrical outlet. Sniping at rich people's yachts is I guess a family tradition but the real problem with carbon hypocracy stories is they really don't take in the big picture. I'm for an all electric civilization; wave, wind, sun and nuke. Google is an extremely valuable part of that as it makes things smarter. They can keep their yachts and hovercraft and jet planes.
This is wrong on so many levels. First off the NSF budget is just pitiful, 6.85 billion in 2009. The physical sciences are flat out starving. Come on, this is the groundwork of our entire technical civilization...how many trillion is that worth a year? And most importantly the examples that he gives...soccer grant, and grant for video game sound. Well all right. The video game industry (which is entirely predicated on math math math more math -- insert joke [head shots]) is like 50+ billion. I think that research may well pay off. The NIH budget is 29.5 billion. I am in the biosciences and if you cut that in half and it would make no difference to the health of this country. Cancer...the same...Alzheimers...Schizophrenia...no progress... My point is that of all the Government research agencies, the NSF is in the most need of some love. This is just shameful.
"Just" quit smoking. "Just" exercise and lose weight. "Just" balance the budget. "Just" get off foreign oil. "Just" win baby. "Just" is the word that betrays the orders of magnitude energetic difference between the running of the mouth and the actual doing of something.
I'm waiting for the announcement. If it is as you say; arsenic in the backbone -> Nobel calling. Nothing mundane about that to a biochemist. It's not, "a totally different form of life" because it would share the same stem but as chemistry it is a big deal. I'm waiting for the announcement.
You're so right. The desktop is moving towards being obsolete -- a work thing. Why should Linux care with the juggernaut Android crushing MS in the real world? Developers, don't even think about the desktop, focus on the phone and the coming andro-pad.
...plotlines if there is some damn website giving out all the magic tricks to the little ones. Battlestar Galactica: WOW! The crew is named Adem and Eeve and then named the primitive planet Urth. V: Wow! The Aliens want our water. Star Trek: Wow! An creature made entirely of some unknown energy. Glee: Wow! Will the gang of misfits prevail?!
Take for example the constant paucity of translators familiar with the tongue of countries we're occupying. Where was the nationwide scholarship initiative for Pashto, Farsi and Arabic -- in High school -- in say 9/12/01? It's not like 10 years later our major problem has been trust and the second one has been trust and the third has been blowing up people accidently due to flawed -- um what is that word I'm looking for? I guess the conspiracy buffs have been right all along.
A good idea. Many other states would be good as well. And you know what, the powers that bee are going to ship the jobs to Cathay no matter what we say.
You need to up-think your evolutionary reasoning.In a an optimal parasite/host relationship the parasite doesn't necessarily desire the extinction of its "habitat". Flu virus is more "successful" than Ebola. I agree that it is pure hubris to think that humans can do one better than evolution in the design side of things -- HIV is only nine genes and we still can't lick it. The danger, as the parent suggests, is that some hobbyist could insert a toxin gene in a virulent bacteria/virus that could cause a lot of pain and suffering. I'm not sure there is any upside to hobbyist gene modification. Using PCR tools to augment "natural" traditional breeding techniques has some merit. GM should only be done under strict supervision.
And if you're still listening, folding even starts on the ribosome before the protein is fully translated. The "relevance" of folding experiments performed in isolation are always of questionable reality.
You have asked the million dollar question. I will give you the pithy answer first; the computer models are inadequate. Real proteins are basically in constant motion; "breathing" and sampling alternative conformations quite rapidly. This is important, first off our cells recycle proteins as a form of regulation; it would be to our disadvantage if all proteins were as rock stable as say, collagen. Foldit also doesn't fully model this bewildering kinetic sampling nor the effects of salt, solvation, etc. As for proteins getting stuck in alternative local minima last time I checked this kind of thing was possible and even an argued basis for Alzheimers amyloid fibrils through a process known as "domain swapping." http://www.pnas.org/content/103/21/8042.short Rosetta/Foldit makes many simplifying assumptions. If does however work quite well and is only getting better as this news report suggests. However, in my work, not every protein need be "structured".
The slacker hangout culture thing about Borders and B&N was always off-putting to me. Doing your homework in a store? What happened to the library? OK so we close those too. Mom and Pop's with a savvy focus, a plethora of used books, and a heavy reliance on E-bay is the way forward.
It's all solar in the end right...just converted to chemical energy. I've read up on the intricacies of bio-fuel and on the whole I'm against it. The trouble is the long term environmental impact of land based fuel crops is horrendous...and all we get is a net neutral in terms of CO2...suck it out of the sky...put it back in.
Algae offers much in terms of land use but little in terms of the CO2 neutrality problem. Much more research needed; don't believe the hype.
I'm for the establishment of a fully electric civilization; solar, wind, wave, nuke.
Hey teach...here's something I've never seen. Is there a web site/book compilation through time of sample term papers and/or essays to plot this pattern? (Forget quantifying it, an educated reader can know what's good.) It would be interesting to see whole classroom samples.
I concur with the possible unforeseen downside of the digital age but have seen little specific evidence.
Why don't all you "Pirates" come together and write a computer program to generate all possible melodies for the 32 bar AABA, form. Then publish the whole lot under the creative commons license or whatever, call western music complete, and then download in peace.
Also these lawsuits are always bunk. Noone ever sues over the harmony do they?
Is the problem with management, or the whole idea of "building an Empire"? And why is it us penny pinching plebes always buy into the notion of Empire anyway? Because the barbarians are coming today... http://www.uvm.edu/~jgm/barbarians.html
Here's how to remake it. In the future Hollywood only has a small select of films to show because they've run out of ideas. The way that they ensure ticket revenues is by killing off everyone over 21. My life clock is black as pitch!
If there is one thing the humaned space program has shown, it's that we're really good at putting stuff together and fixing stuff (cf. Hubble and that hulking massive space station). But the sole brass ring seemingly out of reach -- correct me if I'm wrong -- is refueling. If we can do that multiple launches lock and load just about any vessel.
You make a salient larger point. There's a good deal of lack of respect for nature. Whether it be sailing around the world when you're 16, going to live with Grizzly's, or scaling the Himalayas; good old fashioned awe is at a long time low. Technology is the prime mover I guess in counting coup with a tornado. After the encounter you bring images and tales back to the BBQ and share them with your (now) world youtube tribe who anoints you with adulation and esteem. I've been close to a tornado whilst exposed in the eastern plains of Colorado. There is no record of me lying in a ditch soiling my pants and I'm glad of it. Ooops.
Mod Up. And in the corporate marketplace there is an overt bias against the Ph.D. in favor of M.S. level. (If you've not even considered by HR there is not even any room to negotiate salary etc.)
Slashdot Mirror
Wow. Those genetically modified mice "tga20 transgenic mice overexpressing PrPC" bred to be hyper-susceptible seem to be highly susceptible. After 15+ years of this "ice 9" business I'm still waiting for results that in any way meet Koch's Postulates. Oh yeah, let's stop calling this protein "prion" and start calling it a proteinaceous "toxin" which is what it is. Moreover, since this Nobel Prize winning hypothesis in no way seems to conform with the reality of widely spreading communicable encephalitis in sheep, beef and mule deer why not entertain the notion that this is a slow virus and that the symptomatic misfolded protein is a mere phenotype, possibly detrimental, but not causal. Oh yeah, figuring this out would mean working with big smelly farm animals and we prion people don't like to get dirty.
Meanwhile Laura Manuelidis is fighting the good fight against overwhelming odds.
http://en.wikipedia.org/wiki/Laura_Manuelidis
But what about Good Google? How much carbon is saved each year, for example, by their handy maps? (Now if I could only get my wife to stop printing them out and just write the directions on a piece of waste paper) How much does Google reduce carbon by efficiently locating points of interest -- and someday -- helping you get your car to the nearest electrical outlet. Sniping at rich people's yachts is I guess a family tradition but the real problem with carbon hypocracy stories is they really don't take in the big picture. I'm for an all electric civilization; wave, wind, sun and nuke. Google is an extremely valuable part of that as it makes things smarter. They can keep their yachts and hovercraft and jet planes.
This is wrong on so many levels. First off the NSF budget is just pitiful, 6.85 billion in 2009. The physical sciences are flat out starving. Come on, this is the groundwork of our entire technical civilization...how many trillion is that worth a year? And most importantly the examples that he gives...soccer grant, and grant for video game sound. Well all right. The video game industry (which is entirely predicated on math math math more math -- insert joke [head shots]) is like 50+ billion. I think that research may well pay off. The NIH budget is 29.5 billion. I am in the biosciences and if you cut that in half and it would make no difference to the health of this country. Cancer...the same...Alzheimers...Schizophrenia...no progress... My point is that of all the Government research agencies, the NSF is in the most need of some love. This is just shameful.
"Just" quit smoking. "Just" exercise and lose weight. "Just" balance the budget. "Just" get off foreign oil. "Just" win baby.
"Just" is the word that betrays the orders of magnitude energetic difference between the running of the mouth and the actual doing of something.
I'm waiting for the announcement. If it is as you say; arsenic in the backbone -> Nobel calling. Nothing mundane about that to a biochemist. It's not, "a totally different form of life" because it would share the same stem but as chemistry it is a big deal.
I'm waiting for the announcement.
Hey do you want to make an Android smartphone that plugs into an 19" screen and a bluetooth keyboard? We'll call the company "Mighty Buzzard"!
You're so right. The desktop is moving towards being obsolete -- a work thing. Why should Linux care with the juggernaut Android crushing MS in the real world? Developers, don't even think about the desktop, focus on the phone and the coming andro-pad.
...plotlines if there is some damn website giving out all the magic tricks to the little ones. Battlestar Galactica: WOW! The crew is named Adem and Eeve and then named the primitive planet Urth. V: Wow! The Aliens want our water. Star Trek: Wow! An creature made entirely of some unknown energy. Glee: Wow! Will the gang of misfits prevail?!
Take for example the constant paucity of translators familiar with the tongue of countries we're occupying. Where was the nationwide scholarship initiative for Pashto, Farsi and Arabic -- in High school -- in say 9/12/01? It's not like 10 years later our major problem has been trust and the second one has been trust and the third has been blowing up people accidently due to flawed -- um what is that word I'm looking for?
I guess the conspiracy buffs have been right all along.
A good idea. Many other states would be good as well. And you know what, the powers that bee are going to ship the jobs to Cathay no matter what we say.
Write RO1 proposing formulation of gut flora's effect on disease x.
Get grad students to torture nude mice.
Measure 10% effect
Profit.
Write RO1...increment formulation repeat
You need to up-think your evolutionary reasoning.In a an optimal parasite/host relationship the parasite doesn't necessarily desire the extinction of its "habitat". Flu virus is more "successful" than Ebola. I agree that it is pure hubris to think that humans can do one better than evolution in the design side of things -- HIV is only nine genes and we still can't lick it. The danger, as the parent suggests, is that some hobbyist could insert a toxin gene in a virulent bacteria/virus that could cause a lot of pain and suffering.
I'm not sure there is any upside to hobbyist gene modification. Using PCR tools to augment "natural" traditional breeding techniques has some merit. GM should only be done under strict supervision.
And if you're still listening, folding even starts on the ribosome before the protein is fully translated. The "relevance" of folding experiments performed in isolation are always of questionable reality.
You have asked the million dollar question. I will give you the pithy answer first; the computer models are inadequate. Real proteins are basically in constant motion; "breathing" and sampling alternative conformations quite rapidly. This is important, first off our cells recycle proteins as a form of regulation; it would be to our disadvantage if all proteins were as rock stable as say, collagen. Foldit also doesn't fully model this bewildering kinetic sampling nor the effects of salt, solvation, etc.
As for proteins getting stuck in alternative local minima last time I checked this kind of thing was possible and even an argued basis for Alzheimers amyloid fibrils through a process known as "domain swapping."
http://www.pnas.org/content/103/21/8042.short
Rosetta/Foldit makes many simplifying assumptions. If does however work quite well and is only getting better as this news report suggests.
However, in my work, not every protein need be "structured".
The slacker hangout culture thing about Borders and B&N was always off-putting to me. Doing your homework in a store? What happened to the library? OK so we close those too. Mom and Pop's with a savvy focus, a plethora of used books, and a heavy reliance on E-bay is the way forward.
It's all solar in the end right...just converted to chemical energy. I've read up on the intricacies of bio-fuel and on the whole I'm against it. The trouble is the long term environmental impact of land based fuel crops is horrendous...and all we get is a net neutral in terms of CO2...suck it out of the sky...put it back in.
Algae offers much in terms of land use but little in terms of the CO2 neutrality problem. Much more research needed; don't believe the hype.
I'm for the establishment of a fully electric civilization; solar, wind, wave, nuke.
Hey teach...here's something I've never seen. Is there a web site/book compilation through time of sample term papers and/or essays to plot this pattern? (Forget quantifying it, an educated reader can know what's good.) It would be interesting to see whole classroom samples.
I concur with the possible unforeseen downside of the digital age but have seen little specific evidence.
Why don't all you "Pirates" come together and write a computer program to generate all possible melodies for the 32 bar AABA, form. Then publish the whole lot under the creative commons license or whatever, call western music complete, and then download in peace.
Also these lawsuits are always bunk. Noone ever sues over the harmony do they?
Is the problem with management, or the whole idea of "building an Empire"?
And why is it us penny pinching plebes always buy into the notion of Empire anyway?
Because the barbarians are coming today...
http://www.uvm.edu/~jgm/barbarians.html
Here's how to remake it. In the future Hollywood only has a small select of films to show because they've run out of ideas. The way that they ensure ticket revenues is by killing off everyone over 21. My life clock is black as pitch!
If there is one thing the humaned space program has shown, it's that we're really good at putting stuff together and fixing stuff (cf. Hubble and that hulking massive space station). But the sole brass ring seemingly out of reach -- correct me if I'm wrong -- is refueling. If we can do that multiple launches lock and load just about any vessel.
I read that the Falcon cost about 700 million to develop, the government was having to put out one billion just to cancel the Constellation program.
http://www.nytimes.com/2010/06/11/science/space/11nasa.html?hpw
You make a salient larger point. There's a good deal of lack of respect for nature. Whether it be sailing around the world when you're 16, going to live with Grizzly's, or scaling the Himalayas; good old fashioned awe is at a long time low. Technology is the prime mover I guess in counting coup with a tornado. After the encounter you bring images and tales back to the BBQ and share them with your (now) world youtube tribe who anoints you with adulation and esteem. I've been close to a tornado whilst exposed in the eastern plains of Colorado. There is no record of me lying in a ditch soiling my pants and I'm glad of it. Ooops.
Mod Up. And in the corporate marketplace there is an overt bias against the Ph.D. in favor of M.S. level. (If you've not even considered by HR there is not even any room to negotiate salary etc.)
Come on. This is so weak and wrong. Now if you excuse me I'm going to go make myself a hydrogen and acetylene sandwich.