Weird just means art doesn't it. One of the most funny things I've noticed in this world is that "artistic" types who go to a gallery and blather on and on about the "freedom" of Picasso, and Jackson Pollock will positively run in terror from music that violates 32 bar AABA song structure. So Zappa is how much weird, he's kind of weird? But you know whenever I feel blue, I put on "Trout Mask Replica", (not Zappa but close) laugh my ass off, and am able to proceed mightily through this world which is much much weirder than Frank Zappa.
Actually the last one, the talking heads montage, seems to be the basis of the "I'm an IBM'r" ads shown even today...and it is interesting how they seemed to have a bit of sense of humor about their stiff image even way back in 1967!
Here's a handy link to the University of Wisconsin Fusion website dealing with the advantages/disadvantages of 3He as fuel http://fti.neep.wisc.edu/research/dhe3 A key feature -- even though it requires more energy, burning D+3He yields far less neutrons which would be an important advantage in a commercial reactor. Fusion is still a dream but there is a lot of action with "alternative configurations" so we should keep our fingers crossed. Me: if fusion can work, why stop at the moon? Betcha there is more 3He to be sucked out of the regolith on Mercury!
It's different for a a lot of reasons. I'll just focus on three. The bio-weapon fear: the viruses and bacteria that we harbor have co-evolved with us. Viruses and bacteria shape evolution in a myriad of subtle ways but one way to look at even the most pathogenic forms is that their habitat is you and me. So despite the suffering inflicted by TB, Ebola, HIV etc. fundamentally it is not in the best interest of the microbe to cause the extinction of its habitat -- although it probably happens. The bio-weapon fear is that pathogens can now be created whose long term interest is not in the "cruel but fair" hands of Darwinian Evolution but in the possibly malevolent (or hopefully beneficent) hands of a bona-fide "CREATOR/DESTROYER". Let's hope Venter is nice. The second: the lateral gene transfer mechanism has been shown to play a role on evolution. However now it is possible to accelerate this "artificial sex" to rates that far exceed the norm. Plant-Animal hybrids here we come -- and let's use our imagination. Plant a seed, up grows the plant, a flower fruits, a butterfly emerges which lays -- seeds. Pretty kewl huh. Three: Genetic twiddling -- there are some parts of the cell that evolution just doesn't take a chance in messing around with. It is now possible to mess around. My two cents: weeds win...the reason algae for fuel doesn't work is weeds. If you go to Indiana you don't see the Monsanto soybeans growing wild in a ditch. And there are no wild packs of Shih Tzus. I'm not sharpening the pitchfork yet.
Integrins. Thanks for the link. That's a pretty intriguing chemical and the possible correlation between mitochondrial metabolism, cancer and apoptosis is what is so interesting to me tonight. Also I'm wondering about NO. Some things in the mix to maybe lower it. Cheers
Gosh, so sorry. Please please forgive me. It's just that whenever I don't have to assign the resonance frequencies of 5200 atoms in a molecule that wants to crash out if you look at it wrong I consider the molecule somewhat simple. 1200 MW to me is something you can leave on the shelf. If you notice the parent asked about proteins and so I too went in to see if there was some kinase, antibody, polymeric polyprotein, siRNA etc. that was the "secret". Obviously not. This mix is pretty complicated but it's basically a buffered media; far less complicated than that being used to grow mammalian cell culture on the lab bench next to mine. I hope this ends up doing a lot of good. I love simple things. I wish that the answer to cancer was something as completely trivial as dichloroacetate. And it is noticing that constituent in this solution and remembering the/. story yesterday I thought I might bring it to everyone's attention. So please forgive me. I promise that with the Karma for which I've long labored I will henceforth act responsibly. Meanwhile I'm kind of busy so if you could dive into the literature and find out for me if the presence of dichloroacetate is causing the heart tissue in question to switch from glycolysis to oxidative phosphorylation I would be very interested. Cheers.
From the paper it's a modification of something called GALA solution. Compenent mmol/L g/L Distilled water, L 1.00 Calcium chloride 1.30 0.191 Potassium chloride 7.00 0.522 Potassium phosphate (monobasic) 0.44 0.060 Magnesium chloride (hexahydrate) 0.50 0.101 Magnesium sulfate (heptahydrate) 0.50 0.123 Sodium chloride 125.00 7.31 Sodium bicarbonate 5.00 0.420 Sodium phosphate (dibasic; heptahydrate) 0.19 0.05 d-Glucose 11.00 1.982 Glutathione (reduced) 1.50 0.461 Ascorbic acid 1.00 0.176 l-Arginine 5.00 1.073 l-Citrulline malate 1.00 0.175 Adenosine 2.00 0.534 Creatine orotate 0.50 0.274 Creatine monohydrate 2.00 0.298 l-Carnosine 10.00 2.26 l-Carnitine 10.00 2.00 Dichloroacetate 0.50 0.075 Insulin 10 mg/mL, mL/L 1.00 pH is adjusted to 7.5 with sodium bicarbonate or Tris-hydroxymethyl aminomethane at desired temperature.
Bunch of salts. These aren't complex proteinaceous molecules. I am interested in the presence of dichloroacetate because that was the anti-cancer molecule reported by slashdot just yesterday. http://science.slashdot.org/article.pl?sid=10/05/13/2117203
Now all you hackers planning to preserve human hearts don't you use this formula without citing the good Doctor Thatte. Please mod me up for my chemical knowhow
I am all for the manned program, but the Bush plan was a guaranteed trip to Nowhere. Science needs to have a role in the planning to achieve deep impact results. A quick survey: The Journal Nature has 32 articles in 2009 from NASA: not one is from the International Space Station (but a good number from the Hubble Space Telescope). This says it all. If we have a meaningful, science focused manned program we will rejuvenate NASA like never before. And that means going somewhere. It means newer and better robots to work hand in hand with the astronauts. People had their livers in a quiver when we found out that the moon was not totally dry but is simply as dry as a bone. Come on man! Get out to the icy asteroid zone and get me some samples. There's this entire branch of science called organic chemistry that is just starved for data and it's going to take a bunch of deep space manned missions to do it! The Augestine/Obama plan is the one to get us there.
A waste of precious NASA bucks better spent on robots (and I mean robots to help the manned program).
And the "isolation" aspect is just bunk -- resource more for deep space transmission of e-mail and skype and the astronauts will be begging to be left alone.
Kudos to the smart people at MIT. Using the same scaffolding substrate as nature, we can match nature's way at 2% conversion. Coupled with automatic assembly and/or extrusion; artificial trees perhaps?
In the big picture they should do this too, though enzymes lower the activation energy of chemistry required. Another killer app for thermal solar furnaces is to power the Haber process to make nitrogen -- currently petrol based -- needed for everything.
I've been following the biofuels industry pretty closely. How about Duckweed? Like algae it does not compete with cropland, it grows fast and unlike algae, it is easy to harvest (just skim off the top rather than concentrating water). Also easier to deal with "weeds" (algae ponds get contaminated by other species and this is hard to control). Duckweed is mostly cellulose and so fits into a feedstream amenable to the fermentation described by the article.
The synergy of government, university, corporation in Silicon valley is glued there by one critical component -- the venture capital lives down the block and they like to see how their money is spent -- daily. Perhaps others have more direct life experience but I've definitely seen it in biotech.
As soon as the lure of big bucks goes away, tech will be a commodity to be found in any medium sized city's office park. The cost of life in CA is insane.
Because I don't want to live in a place where there is absolutely positively no water, no hydrogen at all. None. (almost as bad as no nitrogen on Mars -- don't get me started). Oh yeah, acid.
More trouble than it's worth, I'd rather live IN Mercury, ON Ganyamede, or UNDER Ceres.
First off pick up the book again some time and read the dialog aloud and tell me Herbert's writing doesn't define wooden.
That's OK, maybe the Bible has more in common with this book then say, the slangy chatty "Avatar".
That Lynch pulled in stuff from a different dimension was well and good. I personally think "milking a cat", Gurney attacking with one hand on a gun and the other holding a pug, heart plugs and the tubes going into the brains of the Guild are more poignant than anything in the book.
Lynch's "Dune" sent me to a different dimension. "Avatar" sent me to bed with a headache.
Much needed overhaul of a partially moribund manned program. Putting science first will create a much more meaningful space program in the long run, one in which a manned presence is essential.
Sure but we've got many many years before we lose the sun. And despite all the problems in the world I'm dubious that the end of civilization is neigh.
But here's my proposal, take a hundred bucks, put it in the bank (a good one, go ahead and laugh) and somehow on your deathbed (I assume you're a pup and it grew) direct
the establishment of a fund to subsidize a colony on alpha centauri in 200 years.
The only thing stopping us right now from spreading across the galaxy like dandelion seeds is the money.
Slashdot Mirror
Weird just means art doesn't it. One of the most funny things I've noticed in this world is that "artistic" types who go to a gallery and blather on and on about the "freedom" of Picasso, and Jackson Pollock will positively run in terror from music that violates 32 bar AABA song structure. So Zappa is how much weird, he's kind of weird? But you know whenever I feel blue, I put on "Trout Mask Replica", (not Zappa but close) laugh my ass off, and am able to proceed mightily through this world which is much much weirder than Frank Zappa.
http://www.othermusic.com/
http://www.youtube.com/watch?v=kf8TM4CIk5g
Actually the last one, the talking heads montage, seems to be the basis of the "I'm an IBM'r" ads shown even today...and it is interesting how they seemed to have a bit of sense of humor about their stiff image even way back in 1967!
Here's a handy link to the University of Wisconsin Fusion website dealing with the advantages/disadvantages of 3He as fuel
http://fti.neep.wisc.edu/research/dhe3
A key feature -- even though it requires more energy, burning D+3He yields far less neutrons which would be an important advantage in a commercial reactor.
Fusion is still a dream but there is a lot of action with "alternative configurations" so we should keep our fingers crossed.
Me: if fusion can work, why stop at the moon? Betcha there is more 3He to be sucked out of the regolith on Mercury!
Maybe we should look for the only cell phone hole left on this whole green earth? Well he sure isn't hiding in this Starbucks!
It's different for a a lot of reasons. I'll just focus on three. The bio-weapon fear: the viruses and bacteria that we harbor have co-evolved with us. Viruses and bacteria shape evolution in a myriad of subtle ways but one way to look at even the most pathogenic forms is that their habitat is you and me. So despite the suffering inflicted by TB, Ebola, HIV etc. fundamentally it is not in the best interest of the microbe to cause the extinction of its habitat -- although it probably happens. The bio-weapon fear is that pathogens can now be created whose long term interest is not in the "cruel but fair" hands of Darwinian Evolution but in the possibly malevolent (or hopefully beneficent) hands of a bona-fide "CREATOR/DESTROYER". Let's hope Venter is nice. The second: the lateral gene transfer mechanism has been shown to play a role on evolution. However now it is possible to accelerate this "artificial sex" to rates that far exceed the norm. Plant-Animal hybrids here we come -- and let's use our imagination. Plant a seed, up grows the plant, a flower fruits, a butterfly emerges which lays -- seeds. Pretty kewl huh. Three: Genetic twiddling -- there are some parts of the cell that evolution just doesn't take a chance in messing around with. It is now possible to mess around.
My two cents: weeds win...the reason algae for fuel doesn't work is weeds. If you go to Indiana you don't see the Monsanto soybeans growing wild in a ditch. And there are no wild packs of Shih Tzus. I'm not sharpening the pitchfork yet.
Integrins. Thanks for the link. That's a pretty intriguing chemical and the possible correlation between mitochondrial metabolism, cancer and apoptosis is what is so interesting to me tonight. Also I'm wondering about NO. Some things in the mix to maybe lower it. Cheers
Gosh, so sorry. Please please forgive me. It's just that whenever I don't have to assign the resonance frequencies of 5200 atoms in a molecule that wants to crash out if you look at it wrong I consider the molecule somewhat simple. 1200 MW to me is something you can leave on the shelf. If you notice the parent asked about proteins and so I too went in to see if there was some kinase, antibody, polymeric polyprotein, siRNA etc. that was the "secret". Obviously not. This mix is pretty complicated but it's basically a buffered media; far less complicated than that being used to grow mammalian cell culture on the lab bench next to mine. I hope this ends up doing a lot of good. I love simple things. I wish that the answer to cancer was something as completely trivial as dichloroacetate. And it is noticing that constituent in this solution and remembering the /. story yesterday I thought I might bring it to everyone's attention. So please forgive me. I promise that with the Karma for which I've long labored I will henceforth act responsibly. Meanwhile I'm kind of busy so if you could dive into the literature and find out for me if the presence of dichloroacetate is causing the heart tissue in question to switch from glycolysis to oxidative phosphorylation I would be very interested. Cheers.
From the paper it's a modification of something called GALA solution.
Compenent mmol/L g/L
Distilled water, L 1.00
Calcium chloride 1.30 0.191
Potassium chloride 7.00 0.522
Potassium phosphate (monobasic) 0.44 0.060
Magnesium chloride (hexahydrate) 0.50 0.101
Magnesium sulfate (heptahydrate) 0.50 0.123
Sodium chloride 125.00 7.31
Sodium bicarbonate 5.00 0.420
Sodium phosphate (dibasic; heptahydrate) 0.19 0.05
d-Glucose 11.00 1.982
Glutathione (reduced) 1.50 0.461
Ascorbic acid 1.00 0.176
l-Arginine 5.00 1.073
l-Citrulline malate 1.00 0.175
Adenosine 2.00 0.534
Creatine orotate 0.50 0.274
Creatine monohydrate 2.00 0.298
l-Carnosine 10.00 2.26
l-Carnitine 10.00 2.00
Dichloroacetate 0.50 0.075
Insulin 10 mg/mL, mL/L 1.00
pH is adjusted to 7.5 with sodium bicarbonate or Tris-hydroxymethyl aminomethane at desired temperature.
Bunch of salts.
These aren't complex proteinaceous molecules. I am interested in the presence of dichloroacetate because that was the anti-cancer molecule reported
by slashdot just yesterday.
http://science.slashdot.org/article.pl?sid=10/05/13/2117203
Now all you hackers planning to preserve human hearts don't you use this formula without citing the good Doctor Thatte.
Please mod me up for my chemical knowhow
I am all for the manned program, but the Bush plan was a guaranteed trip to Nowhere. Science needs to have a role in the planning to achieve deep impact results. A quick survey: The Journal Nature has 32 articles in 2009 from NASA: not one is from the International Space Station (but a good number from the Hubble Space Telescope). This says it all. If we have a meaningful, science focused manned program we will rejuvenate NASA like never before. And that means going somewhere. It means newer and better robots to work hand in hand with the astronauts. People had their livers in a quiver when we found out that the moon was not totally dry but is simply as dry as a bone. Come on man! Get out to the icy asteroid zone and get me some samples. There's this entire branch of science called organic chemistry that is just starved for data and it's going to take a bunch of deep space manned missions to do it! The Augestine/Obama plan is the one to get us there.
This has clearly been done.
http://www.washingtonpost.com/wp-dyn/content/article/2009/09/21/AR2009092103723.html
A waste of precious NASA bucks better spent on robots (and I mean robots to help the manned program).
And the "isolation" aspect is just bunk -- resource more for deep space transmission of e-mail and skype and the astronauts will be begging to be left alone.
Kudos to the smart people at MIT. Using the same scaffolding substrate as nature, we can match nature's way at 2% conversion. Coupled with automatic assembly and/or extrusion; artificial trees perhaps?
Amen brother. And nothing is more sucky than being an out of work brain. (Reading /. all day.)
Thanks for that. Mod up please.
Perhaps we're all Italians now?
That ad for a pair of super advanced Gremlins intermingled with Teller's bold prediction kind of says it all.
In the big picture they should do this too, though enzymes lower the activation energy of chemistry required. Another killer app for thermal solar furnaces is to power the Haber process to make nitrogen -- currently petrol based -- needed for everything.
I've been following the biofuels industry pretty closely. How about Duckweed? Like algae it does not compete with cropland, it grows fast and unlike algae, it is easy to harvest (just skim off the top rather than concentrating water). Also easier to deal with "weeds" (algae ponds get contaminated by other species and this is hard to control). Duckweed is mostly cellulose and so fits into a feedstream amenable to the fermentation described by the article.
I also write poetry. :) My bad.
The synergy of government, university, corporation in Silicon valley
is glued there by one critical component -- the venture capital lives
down the block and they like to see how their money is spent --
daily. Perhaps others have more direct life experience but I've
definitely seen it in biotech.
As soon as the lure of big bucks goes away, tech will be a commodity
to be found in any medium sized city's office park. The cost of life in
CA is insane.
Because I don't want to live in a place where there is absolutely positively no water, no hydrogen
at all. None. (almost as bad as no nitrogen on Mars -- don't get me started). Oh yeah, acid.
More trouble than it's worth, I'd rather live IN Mercury, ON Ganyamede, or UNDER Ceres.
First off pick up the book again some time and read the dialog aloud and tell me
Herbert's writing doesn't define wooden.
That's OK, maybe the Bible has more in common with this book then say,
the slangy chatty "Avatar".
That Lynch pulled in stuff from a different dimension was well and good. I personally
think "milking a cat", Gurney attacking with one hand on a gun and the other holding
a pug, heart plugs and the tubes going into the brains of the Guild are more poignant
than anything in the book.
Lynch's "Dune" sent me to a different dimension. "Avatar" sent me to bed
with a headache.
Much needed overhaul of a partially moribund manned program.
Putting science first will create a much more meaningful space
program in the long run, one in which a manned presence is
essential.
Here's another wild concept in fusion:
http://www.generalfusion.com/
Be nice if it works before you're 60!
Probably true but I am praying for these guys (not a Polywell).
http://www.generalfusion.com/
Sure but we've got many many years before we lose the sun. And despite all the problems
in the world I'm dubious that the end of civilization is neigh.
But here's my proposal, take a hundred bucks, put it in the bank (a good one, go ahead
and laugh) and somehow on your deathbed (I assume you're a pup and it grew) direct
the establishment of a fund to subsidize a colony on alpha centauri in 200 years.
The only thing stopping us right now from spreading across the galaxy like dandelion
seeds is the money.