Cloning License for Dolly's Doc
Rollie Hawk writes "Ian Wilmut, leader of Dolly the sheep's team and Professor at the Roslin Institute in Edinburgh, has been given the green light by the British government's Human Fertilisation and Embryology Authority to start further cloning research. As a matter of fact, he is now a licensed human cloner.
The license has a duration of one year and is the second of its kind given by Britain, the first country to officially sanction human cloning research.
Research will be focusing on motor neurone disease (MND). The team hopes to perform cell nuclear replacement on the skin cells of MND victims in order to create stem cells, the jack-of-all-trades of the cell family and the supposed magic bullets for ailments ranging from Alzheimer's to paralysis.
I am not sure, whether this is really such a grand idea -- yes, genetics
and cloning hold enormous potential, but I think with the current
knowledge of this subject there should be a moratorium on actual
experiments (especially on human cells) until we learn more of the
background of the whole thing - and especially, until we have some form
of agreement on ethical standards about what we want to achieve and how
far we are willing to go.
(Note: this is not the "we should leave this to god argument" -- simply
because I am agnostic. But somehow I think before we start "playing
god", we should at least get to know whatever we can on a theoretical
level, before we go about practical experiments on it and decide what
should be allowed and what should be off limits... )
I certainly welcome our new cloned human overlords..
as long as they all look like the olsen twins.
For driving medical research overseas! Boy, I'm sure glad this is being done in Britain instead of in the good ol' USA, where we don't condone any science that doesn't make creationism a central tenet!
Isn't this story a dupe?
So who got the first one?
Clones are people two.
10 print "clones are people" $d
20 let $d = pun
30 gosub hilarity
"show me all the blueprint show me all the blueprint show me all the blueprints"
just cure my fucking diabetes already.
I was thinking of making a novel called Human Farm In it, they clone people to do brain transplants. The first batch doesn't have muscle development because they grew them without true lifelike interactions. This spawns a sicklike monster of a person who had to be emergency transplanted to save their life. The next batch is grown up with the help of a nanny in a secure environment. Later the nanny learns of the sick proceedure, so the third batch she trains them to be sick martial arts trainers who are highly moral, also in the third batch, they decide to transplant the young ones into the old bodies so they can get some extra work out of them. One of the young ones gets transplanted to an old person before the plot to rebel happens. So later the old guy has to kill his young self to prevent something serious from happening, forever dooming himself to the old body. Lots of plot twists and a demonization of old people trying to extend their life through use of young people's lives. Properly written it could be good, but I doubt my writing skills, and I don't know if I want to pollute the culture with some of my warped ideas.
God spoke to me.
As a matter of fact, he is now a licensed human cloner.
Something tells me he wouldn't have a problem creating a fake ID if he really needed one.
How certain can they be that these embryos, grown to possess the characteristic genome of an MND victim, will effectively emulate the conditions they need? Dolly, in many respects, raised questions over how clones react to their existence: she died prematurely as if she had aged too fast. Who's to say that these embryos don't possess unknown characteristics simply as a function of being cloned?
Heh. So the whole "ethical issues!" and "scary frankenstein stuff!" and "do we have the right to play god?!" stuff was really just a disguise for: how can we tax this?
He has a license to clone human embreyos, not clone humans which would be an entirely different matter. The purpose being so he/his team can study diseases which effect motor neurons, by growing them from cloned embreyos using the material from a sufferor of motor neuron disease.
Oh crap! This is England's first step in building a clone army to conquer the world. I've had visions of this army and their teeth look like this.
Where did you get the name "Crazy Jim"? Come up with it by yourself, or is that what the psychiatrists refer to you as?
Deja Vu.
One line blog. I hear that they're called Twitters now.
We're better at starting wars we can't finish.
And condemning things to Hell.
Oh! And getting fat. We have more fat than the rest of the world combined.
"Live Free or Die." Don't like it? Then keep out of the USA
maybe the Coors twins perhaps? I'm of the age where the olsen twins (anorexic or not) still look like jailbait.
(Shudder). Just imagine the horror: a world in the grips of stale dialogue, bad acting, the lack of real suspense or characters you can care about...
the RIAA is watching these developments closely.
Steve Ballmer is crazy! That man has not got the slightest grip on reality.
Just think, if we can get some liscenced geeks into the cloning scene, we can produce an army.
It was as if a thousand jocks cried out in terror, and then were suddenly silenced.
That somehow these embryos are grown beyond their cellular stage into an actual fetus or beyond... and then cut up for testing. (Hey, it's just a clone, it doesn't feel nuthin...) But I don't see this happening here.
Second that this research ends up developing some sort of "clone virus". (IE We engineer enhanced immune systems for cancer. The antibodies are so good that they go airborne and start attacking other humans who can't defend the attack unless they too have the enhanced systems... I think this was a Star Trek: Next Gen episode too). That's possible, but not very probable.
Yeah, there's always the chance that we'll unleash bio-armageddon upon our species. But the military has had that power for decades now and we haven't blown ourselves up... yet...
I would mod this insightful if I had the points,
between[a] "if you or your institution have the money, anything goes" which hasn't happened yet because [1] its still damn hard to do anything in cloning and [2] if some body with money like Gates and mind like Jacko wants himself copied to live forever, don't you suppose that would get secrecy that would make NSA look like a bunch of blabbermouths?
and [b] "God told me and all of my friends that could find a polling booth that every sperm is sacred and science should be put to good uses like weapons research...don't you touch a f**king embryo or we'll kill you." which HAS happened since separation of church and state has broken down pretty badly in the country that first implemented the concept.
License to clone.
Garg
Garg
Alumnus, Xavier's School for Gifted Youngsters
The nazi party de-humanized the jewish people, after that it was acceptable to perform all sorts of horrific experiments.
We've already de-humanized the unborn. (Don't get me wrong, I'm all for abortion in cases where the womans consent to intercourse was impaired or they would have real medical problems, anything else is stupid and selfish).
If we de-humanize full clones and experiment on them are we really any different?
Why do people think that some one is going to go spend BILLIONS to create an army of human clones? Get real, no one is going to spend the money so I don't see how the research could possibly be a threat.
what's the big deal!?
http://www.clonaid.com/news.php
I for one aren't too stuck on the notion that we would create humans just for harvesting organs....
Heck, if we can somehow just grow a specific organ to replace a bad one, even better.
Hopefully they will find great successes, and we can smack some of those stuck on the idea that we shouldn't be "playing god".
First of all they're not the Olsen Twins, they're now the Olsens you insensitive clod!
Seriously, they should really look like...just check my sig. I won't change it anytime soon. I hope.
You can hold down the "B" button for continuous firing.
...breeding dogs and crops. More recently in developing the modern laboratory rodent. Gregor Mendel dabbled in it with flowers. And the biggest genetic engineering disaster known? The mule, because it can't breed. (Disaster from the perspective of the mule species, not necessarily of the environment.)
The biggest difference I see today, for a mostly lay perspective, is that we don't wait for the female animal to be in heat, then throw a male of the species we want to cross with her in the room. We use artificial means.
However, I don't think anyone would take kindly to the thought of breeding humans. (And that's been covered in lots of horror/science-fiction books.
tasks(723) drafts(105) languages(484) examples(29106)
The Nazi's tested Malaria medicines for effectiveness on concentration camp prisoners.
Would you "throw up roadblocks" to such research because of some vague personal notions of "ethics"?
SYNTAX ERROR, Line 30: Stop calling me Hilary.
We're only one lab 'accident' away from unleashing the zombie hordes.
Popcorn anyone?
I really don't like the idea of harvesting stem cells from embryos (but I'm not going to fight tooth and nail to stop the inevitable, we don't reject what the Nazis learned simply because of their methods, but we certainly don't condon their actions either) so what I'd like to see is science looking for ways to get stem cells by other means. We used to scratch the scalps on people with headaches to let the blood out to make the headache go away. Now we use Aspirine.
Rather than trying to solve these problems by going directly for the (quite possibly misguided) "magic bullet" I'd like to see science spending more time trying to cure these things with "not so magic" bullets which I don't think anyone has a problem with. The problem is this idea that embyonic stem cells are an inevitable success. Which, it's not. But this idea is thrown out there and so less controversial sources of stem cells are quickly dismissed.
Like it or not, at least in the US, scientists need government funds to do these experiments and in the US we have a president and a large vocal population who isn't going to let government funds support these types of experiments. If private funds could do the job then there wouldn't be a problem. But even the wealthy private sector isn't too keen on this stuff either.
As a result, science needs to find ways to solve problems that stick to the ethical guidlines dictated by the people whether they happen to like them or not.
The UK rushing to this magic bullet without considering alternatives is a bad idea.
I'd be more inclinded to be happy about this if challenged, conclusive studies existed that alternate sources of stem cells were 100% unviable to cure various problems.
Those studies currently do not exist.
Work Safe Porn
The poster is referring to embreyonic stem cells, which still haven't been proven to be any useful. I still say more adult stem cell research is needed, especially since I've heard things about experimental methods to cure Type1 diabetese using adult stem cells, and things about people pushing states (Mass. in particular) to fund embreyonic stem cell research to try and cure diabetese.
Point is, of course, that I'm bitterly opposed to embreyonic research for the pure and simple reason that it's going nowhere while adult stem cell research is over 100 diseases and thousands of successful treatments into its life cycle, and holds all the same potentials. Both flavors have been getting something like 300 million greenbacks per year from NIH.
Support my political activism on Patreon.
Go and ask his parents if they think research into MND is worth it.
They work better, and we don't have to destroy human tissue. Now Joel Salatin thinks that saying that chickens fed dead cows is safe is like an abortionist grabbing a wiggling baby and saying it's just tissue. I thought so too, but had not found such a funny way of putting it. See some of the non-embryonic stem cell work to see how ridiculous it is.
What fun would life be if it were not random. I mean playing God might sound like fun and all. But I disagree with it becuase I think that it would just take away from the greatness of life. Make better computers, make most stable OSs, make cleaner-fuel, but lets not take away from the value of human life.
so.. if an embryo starts to become too much like a human is he obligated to kill it?
The problem i have with theraputic cloning is that it's exactly the kind of cloning we shouldn't allow, being the microscopic (or in a particularly ghoulish world, full-size) equilvalent of having a baby to harvest its heart.
I really don't understand why people opposed to reproductive cloning on some kind of moral argument can turn around and support theraputic cloning. I mean, so what if people want to have vanity babies that are nearly copies of themselves?
Can you be Even More Awesome?!
I don't care what ethical/philosophical arguments anyone employs regarding cloning.
I for one would be pissed if I realized that I am the cloned version of someone else.
(It's probably impossible to create an EXACT clone; but still, I'd kick my original's ass, for he would likely be older than I am, and I enjoy beating up old people. Ok that last part was a joke.)
It's happening. A better question, and actually germane to this story itself, is "will licensing cloning researchers help control abuses of the industry?". It's probably more effective than merely banning the abuses, or banning the practice altogether. It gives an outlet and encouragement to the very attractive cloning practices that are very clearly use of the technique, and not abuse. But I'd bet that Bill Gates has several clones growing somewhere - he knows they only get them right by version 3.0.
--
make install -not war
Usually the ratio of posts to posts by those who actually read the article is around 10:1. But this time the submitter included 4 links. Every lazy iwontsaywhat took one look at the subject and then wrote their preexisting opinions, formed by the same exemplary openmindedness they just exhibited, of course. Apparently jackelfish is the only one who even skimmed the article.
Or fold your hands and let Slashdot become a sad mockery of itself.
But when you *clone* something, everyone screams, think about our children, when it is really totally harmless
I don't have any answers, but feel compelled to point out that so far cloning is not known to be harmless. Specifically, as far as I know all cloned mammals have a cell age equivalent to that of the cell donor. The cell age is measured by the length of the cell telemers. (When the telemers become too short, the cell dies. Telemers get shorter with every cell division.)
--- -- - -
Give me LIBERTY, or give me a check.
What if the particular gene you're trying to screw with is the one which you need to screw with in order to cure something like cancer? Is that still bad?
Karma: It's all a bunch of tree-huggin' hippy crap!
The only real way to perfect repoductive cloning is to keep perfecting the methods through practice. I say just get on with it and start practicing, that way the methodologies have a reasonable chance of progressive improvement over the long-term.
We could also start attempting to bind cloned humans with machinery and computers in order to create super-humans. It's all going to happen at some point, so why not get started now?
Reminds me of a line from Teenage Mutant Ninja Turtles (cartoon) "[Angry voice] Who's idea was it to put the 6pm news on at 1:00?! [Changes to happy voice] It's brilliant - we'll get the jump on all the other networks!"
Physicist, consultant, science communicator
Was I the only one that misread Cloning as Clothing? I thought someone was trademarking/copyrighting/patenting clothes made from Dolly's wool.
yes, but perhaps they could teach the new one to do "developers" chants at open source gatherings
Too late, Elvis has already been cloned so many times that they lost their mandate on the matter.
using telomerase - it's an enzyme discovered by accident in cancer research. Cancer cells express it atopically and have infinite lifespans (killing you). Telomerase is supposed to be active in the cells that give rise to your sperm and egg to keep them forever young.
I for one would be pissed if I realized that I am the cloned version of someone else.
I've been friends with several pairs of identical twins, and they didn't seem particularly pissed off.
Then again, we're not really a part of the rest of the U.S. anymore anyway.
just cure my [intercoursing] diabetes already.
Which type are you? Go on a restricted-carb diet such as the Atkins plan and your cells will slowly recover from the insulin resistance of Type II diabetes mellitus. Type I, on the other hand, is an autoimmune disease. Research continues on immunosuppressant treatments that will give the islet cells of the pancreas a chance to rebuild themselves. Detect it in kids when they're young enough and they won't even need a pancreatic transplant.
Just need two...
One to go and negotiate
The other to keep a finger on the button
I applaud Britain being the first country to officially sanction this research. Here in the United States of Christian Fundamentalism we won't be seeing that happen for a while. Just don't get too far along with it before our corporations buy all your patents, or you might be added to our fearless leader's must-conquer list.
And then send the little bastard to work while I take the first flight to jamaica to plant my pasty white ass on the beach for ... how long do clones live anyway?
Join the Slashcott! Feb 10 thru Feb 17!
I disagree, but I respect your opinion because you are civil about it.
The way I see it, therapeutic cloning is no worse than taking a tissue sample back to the lab for analysis. Its really just part of you thats growing somewhere else. Its like using part of the pelvis for bone repair elsewhere.
What strikes me as hypocritical is Christian "Pro-lifers." They're vehemently for the preservation of "life," but the religion they so actively support is the one that has directly caused the most human death. I wonder how much they would care if it was just atheist or muslim embryos being harvested.
So what is the penalty for being an unlicensed clone?
They say the mind is the first thing to
...I'll teach my clones about the scientific method and make sure they vote (and post on Slashdot) with their brains and not their Bibles. Seriously, people, no one will attempt to clone a human baby until we've made damn sure that we know what we're doing. All genetic research != cloning a human baby.
They should clone Bill Gates. He is so smart and such an innovator. His products ROCK. They should also clone Al Gore as he invented the Internet and we need his help with Internet 3-6 (Internet 2 is almost done).
In twenty or thirty years, nanotech will be shuffling genes like a deck of cards in Maverick's hands...
And also shuffling human cells the same way...
You ain't seen nothing yet.
Cancer will be history, the common cold a memory, and in a few decades every female will be able to look as good as one of the Corrs and every male look as good as...well, maybe not Jim...:-)
And cloning? Who cares about that? There is virtually NO advantage to cloning a human in terms of the end result as an adult human. There obviously are useful research results to be gained by doing human cloning research, but as a practical matter, no one has yet brought up a reason to actually clone a human with the express purpose of producing a cloned adult - other than to prove it can be done - which is a fairly lame reason to do it.
Wait until nanotech allows the EXACT DUPLICATION of a human being from the molecules on up. That's when things will get interesting. However, that probably won't be on the agenda for another fifty years or so, at least. And by then, it might be made irrelevant by other nanotech applications of farther reaching importance.
No, all of this hand-wringing comes from the usual group of philosophically-challenged "ethicists" whose sole function is to prove themselves more "ethical" (and by implication, therefore, "better") than other people.
Richard Steven Hack - This sig is TOO GODDAMN SHORT TO DO ANYTHING USEFUL WITH! MORONS!
Can I go ahead and put in my order for new kidneys and a liver? I might also need a heart, too... we'll see.
Either way, I need to go ahead and start making payments on it soon, because by the time they're all paid off I'll probably need them.
The Chronic *WHAT* les of Narnia!
"And then the whole fetus issue, which is pretty much mute in a world without souls."
Ergo, fetuses don't have souls so killing them for medical experimentation isn't a problem.
Yeah, that's a real "humanistic" attitude right there.
It's not a "God doesn't like it argument" Your statement right there is a perfect example as to why people have ethical problems about the whole issue.
Soylent Green anyone? I mean, c'mon it's only dead human flesh... It's not like you're eating someone's soul!
For starters, at every conception, a almost-always unique MHC (Major Histocompatibility Complex) comes into existence. This is the celluar identifier for all of the organism's cells, including stem cells.
Thus, for stem cell therapy, there is an initial problem of not being able to use stem cells for any other individual without suppressing the immune system of that indiviudal. Doing that suppresses any ability of the indivduals immune system being able to suppress any random cancer cells tht might appear in the individual.
The only workaround seems to be to cultivate stem cells from the individual to be treated therapeutically and modify the resultant stem cells as the basis for some therapy.
Secondly, there is a rapidly evolving area in molecular genetics called "epigenetics" whose potential impact on stem cell therapies is still under study.
Epigenetics deals with the function of some chunks of RNA (called micro RNA)in what used to be called "junk DNA" that functions genetically by attaching methyl groups to certain regions of genes to, generally, silence those genes. Micro RNA is a part of the genome passed to offspring, but I don't remember offhand the female-male contribution roles or even if they are already determined.
Just more stuff to make it apparent that stem cell therapies are not a slam-dunk type of certainty.
is that the religious anti-cloning campaigns have shot themselves in the foot on this issue. They argued that scientific cloning is playing god and should not be allowed to create humans in labs because these clones wouldn't have souls. The response was since they don't have souls, they are by definition not people, just a bunch of cells, they therefore have no human rights, and science can do as it pleases with the clones. They should have argued that all clones ARE humans, they have human rights, and it would have stopped this in its tracks.
Ian Wilmut was interviewed on the BBC Today Programme yesterday, and was asked about this very issue, and he uneqivically stated that this approach will not work for MND, and they where researching this area with this approach because adult stem cell research had failed.
In a current molecular biology class, we're discussing certain ethical issues. While this post is not necessarily relevant to cloning, it also poses some similar problems.
There's a spin-off project of the Human Genome Project called a HapMap project. Humans for the most part share nearly all of our genetic information. The base pairs differ every so often, and these variations (single nucleotide polymorphisms, SNP) are mapped out to create a haplotype. The current research is geared towards greating a database for people of distinct geographic origins. I hope you can begin to appreciate why this is controversial.
Some other issues that have the potential to crop up in the near future include the ideas that if there is a proven linkage between certain geographical populations and a disease state, abuse by insurance companies might occur. Just imagine this, they refuse you insurance or charge you a premium just because your population is shown to have a higher chance of contracting the disease which you are trying to get coverage for. What about doctors having biases towards a diagnosis for the very same reason?
Lastly, if you didn't pick it up before, the HapMap project has the potential to provide a biological basis for racism.
Just some food for thought.
jackelfish writes:
They are not creating embryos, they are attempting to create pluripotent cells, from skin cells, in an attempt to replace malfunctioning neurons. There is not an entire organism involved here as they are not using gametes (eggs or sperm) in these experiments.
From the second linked article:
Prof Wilmut now plans to take the DNA from the skin or blood of a person with motor neurone disease and implant it into a human egg from which the genetic material has been removed.
As was proved with Dolly, this creates a cell which functions as a zygote. I.e., if implanted in a uterus, it can develop and eventually be birthed. This is precisely what it means to be an embryo. This is a simple statement of fact and is not controversial.
jackelfish continues:
This is where the term "cloning" becomes confused, in that many people think it always refers to the duplication of a whole organism (such as Dolly) where it simply means to insert foreign DNA into a cell.
Whether to call this cloning is a controversial question. One way to look at this is to try reducing this to a simple question. Everyone agrees that Dolly is a clone. But when did Dolly become a clone? At birth? At implantation? When the nuclear replacement was done?
I personally think the last of these is the only sensible option. But I recognise that some people disagree.
Given that they're a market, the GM companies will market the seeds for less than they do in the United States. The problem comes in that they want the money every year, the farmer can't reseed. So it's a tough financial decision.
As for starving nations, it's been said that in most cases they're starving not because of lack of food or transportation to get it there, but because of the political/war situation in the area. Usually those people are starving because the government/opposing faction in the area wants them to be starving, and are willing to back that up with weapons.
eventually contributing to more unemployment, especially among unskilled labour).
Uh, farming isn't exactly unskilled labour anymore. And if you're talking about hands to harvest, GM crops don't magically elminate that need.
genetically modified food doesn't offer nutrional advantages over regular non-GM food.
Well, there's "golden rice" that contains a nutrient not found in natural rice, but as I understand it, that was done by a non-profit group or something. But yes, most of it isn't any better nutriciously than the other mass market large-production crop types. There are usually other breeds that don't produce as much, but have better nutricion/taste.
I don't read AC A human right
...in the end, cloning will find its way, no matter of the ethics involved. Of course, the ethics are important, but if we look at the discussion, we can see how legislations already circumvent (or deny) ethical consideration while they can (theoretically) maintain they ethically have considered the matter. There are two different discussions important here: 1) how much suffering can we force upon a certain group to 'please' the masses and 2) when do the beings of the first group become entities that can experience suffering as a human being? The first is a dodgy one and generally, utilitarian views are proliferating here: as long as the sum of 'happiness' is bigger than the sum of suffering (ie happiness increases through the emergence of new technologies), we should be allowed to pursue these goals. Benthamian thinking, as it has been dubbed by some, would for instance allow a judge to hang an innocent man, as long as the net positive result of that hanging (preventing riots for example, Jeremy Bentham was an 18th century philosopher) eventually supercedes the unhappiness of the man sentenced to death. Pleasing the public one might say. The second point of discussion is indeed about the distinction between a bunch of cells and a human being. Although ethicists have come up with 24 stages of embryo development to make pondering about the acceptability of several techniques more straightforward, many people active within ethics have decided to stay clear of this lengthy discussion and focus on the parents and scientists intentions instead. It is said we are not allowed to solely create embryo's for research purposes, but when an embryo has already 'come into being' it is another case. By law, it is illegal (at least in most European countries) to culture embryos strictly for research ends. However, the thousands of surplus embryo's that come available through in-vitro fertilization and similar assisted reproductive technologies can be wielded for research. So it seems law-makers already decided to skip the discussion on what is human and what's not and already found ways to please the public, despite of any negative consequences. We can talk about disputable business in the public and private sector, but the fact remains that there are always some loopholes (especially in medical research) to circumvent ethical enquiry. And while these loopholes are mere legislative, commerce eventually promotes the loopholes to loop-black-holes. With suction, you know...? I hate philosophy.
You do not exist. Go away.
The old guy's really been letting the side down recently. Perhaps a spell on the sub bench would help him concentrate. Let someone else play the position for a while, then when he comes back on he'll be all fired up and ready to go. So long as he doesn't go back to those 'fire and brimstone' plays. There's really no call for that in the modern game.
If the first human clone is born less than nine months from now, it'll make this the first "shotgun" cloning license.
"For a successful technology, reality must take precedence over public relations, for nature cannot be fooled."--Feynman
All we do now is take existing sets and mix them with other existing sets. And that IS very much the same as breeding. Just a tad faster and more efficient. We HAVE been manipulating genes from before we could write. And modern genetic engineering isn't all that different. I'm puzzled on why you think it is.
New 007 movie ?
"If we don't play god... who will?"
I guess it's just a matter of taste. At least you didn't say the Olsens.
Not only is this a good idea but its a good idea at this time.
We are too concerned about preventing research when life(to some level) is involved but we don't give it second thought when we take life through abortion and other means.