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Overly Sanitized Environments Lead to Poor Health?

bignickel writes "A recently-released study examined the health implications of living in an overly hygienic environment. According to the 'hygiene hypothesis,' living in such an environment early in life can lead to problems with allergies and autoimmune diseases. The study compared lab rodents with rats and mice living in the wild. Time to stop Lysol-bombing the house?"

74 of 352 comments (clear)

  1. Farm Workers Without Allergies by eldavojohn · · Score: 5, Insightful

    I'm not a doctor but I couldn't agree with this article more. I grew up picking rock, bailing hay & working with animals. Countless times I'd come home with dust, alfalfa or straw everywhere (eyes, nose, clothes, etc). I worked with a lot of people and every member of the family worked as soon as you were able to lift something. What was odd was that you had entire families and not one of them would have allergies.

    Now, I'm sure there are exceptions but I think that it would be an interesting survey to compare people who work in dirty grimy environments with people who work in corporate America. I spent my childhood running through the weeds, pulling wood ticks out of my hair and watching my mom put iodine all over my cuts & scrapes (hurts like a b*tch). Although by some people's standards I grew up in utter squalor, it was a lot of fun.

    I have two cousins who moved to Minneapolis and grew up in a house with an air filtration system. The tiniest pollen or cat dander will send them into sneezing fits. Those air filtration systems are more harm than good in my opinion.

    To my knowledge, I don't have any allergic reactions or hay fever. Now, this is just my personal experience but when I lived out in the country, I didn't know anyone except my teacher who had hay fever. Once I went to college at age 18, I met tons of people with hay fever. Is this correlation due to the fact that our childhoods were spent in filth or is it simply because people with allergies move away from those areas? I'm not sure but considering that allergies can "develop" later in life, I'm prone to believe that the less you are exposed to tiny particles, the more your body wigs out when your immune system encounters them.

    If you're a parent, I would suggest getting your toddler/infant out to the park as often as possible and let them get some fresh air. Yes, it has smog & pollen in it but everyone has to deal with these their entire lives.

    There's no analogy to be used here, it's just simply speculation. They've done this study with lab mice, now why don't they do a sampling of populations and ask people whether they work in an office with a controlled air system or outdoors/farm work where they're exposed to plants & animals daily.

    The human body is extremely adaptive. Anti-bodies are perfect examples of an immune system being exposed to something and then being able to deal with it later. I speculate that if people aren't exposed to dust, pollen, dander, etc. then their bodies will have a much more difficult time discerning them from actually harmful foreign particles.

    --
    My work here is dung.
    1. Re:Farm Workers Without Allergies by wwest4 · · Score: 2, Informative

      I'm also not a doctor, but I've heard that the human body can also become aware of an allergen after repeated exposure... poison ivy or cat dander, for example. People who were not allergic to these things can apparently develop an allergy to something that didn't elicit a reaction before.

    2. Re:Farm Workers Without Allergies by Schraegstrichpunkt · · Score: 3, Interesting
      There's no analogy to be used here, it's just simply speculation. They've done this study with lab mice, now why don't they do a sampling of populations and ask people whether they work in an office with a controlled air system or outdoors/farm work where they're exposed to plants & animals daily.

      That information, while useful, would probably be less useful than you might think. Even if you discount the typical problems associated with questionnaire-based studies, such a study will won't distinguish between problems caused by sterile environments and problems caused by different allergens that may be associated with air conditioning systems or with urban areas in general.

    3. Re:Farm Workers Without Allergies by Otter · · Score: 3, Interesting
      Now, I'm sure there are exceptions but I think that it would be an interesting survey to compare people who work in dirty grimy environments with people who work in corporate America.

      IIRC, the original study that popularized this idea compared Germans who grew up in cities and on farms and found a lower rate of allergies in the latter.

      As for this mouse study -- lab mice and wild mice are extremely different animals, as lab mouse strains (which used to be pet mouse strains) as have been selected for two hundred years to grow in close quarters. It's very hard to distinguish environmental and genetic effects in this case.

    4. Re:Farm Workers Without Allergies by Anonymous Coward · · Score: 2, Interesting

      While the theory really appeals to me, my life experience indicates otherwise.
      My father grew up in a farming family and, like most, he was expected to pitch in and work from an early age. However, he also has severe allergies to grain dust, pollen and a number of other respiratory related things. These just got worse over the years. When he helps out on the farm now, he actually wears an aspestos removal suit with a breather unit. I grew up in a sterile house - excessive vacuuming and cleaning. While I too have allergies, they're not nearly as bad as my father's.
      The one aspect I could believe is that my father's allergies got worse when he stopped being exposed to irritants on a regular basis. However, he's always been allergic despite frequent early exposure.

      No Clue

    5. Re:Farm Workers Without Allergies by hindumagic · · Score: 5, Interesting

      Like you said, that is your *personal* experience.

      Whereas I grew up just as you did, playing outside, lots of different animals, hay, etc. Not a Lysol environment at all. And then around 10 years old, while making tunnels and forts in a big pile of haybales with friends I got hit with the hayfever. Around the same time I developed an allergy to cats. My father is exactly like this and his father is as well (allergic to cat dander and have hayfever).

      Oh, and you can be born with allergies. I'm allergic to penicillin - given some as a newborn and developed a rash (apparently a common allergic reaction to it).

      I'm sure that there are others that can refute your hypothesis.

      But I still believe that it is good to not grow up in a sterile environment. I'm not thinking about allergies, but just about having an immune system that gets some exercise and building up a catalog of antibodies that can respond to similar threats. (in fact, isn't the allergic reaction your immune system's response to that allergen?)

    6. Re:Farm Workers Without Allergies by Gulthek · · Score: 4, Insightful

      Doesn't quite work as reliably as you think. My wife has bad allergies to cat dander, but grew up surrounded by pets and helped work her mother's pet store.

    7. Re:Farm Workers Without Allergies by f0rtytw0 · · Score: 2, Insightful

      This seems to be the case for me at least when it comes to pollen. Never used to have any allergies at all. Now when June rolls around I find myself sneezing and constantly blowing my nose. At least it wasn't as bad this year but it still sucks. It all started when I moved from one apartment to another and that kicked up a lot of dust. This is my third year of it and I really hope it goes away =P.
      Now to go the other way when I first got poison ivy it was really really bad. Each time after that was not as bad. Now I'm not overly concerned about it, there might be a small reaction that isn't very itchy. I do think some of it has to do with the environment I live and work in. I went from living out in the woods to living in the city. I also work all day indoors (which really sucks on nice days like today).

      --
      this is the most important sig ever! In your face 446154!
    8. Re:Farm Workers Without Allergies by Ryanwoodings · · Score: 5, Informative

      The May (2006) issue of National Geographic has an article titled "The Misery of Allergies", which lends a lot of credibility to your story. The article says scientists aren't sure what causes allergies, but there is evidence that shows that growing up in "dirtier" environments leads to fewer allergies.

      http://www7.nationalgeographic.com/ngm/0605/featur e4/index.html

    9. Re:Farm Workers Without Allergies by Twanfox · · Score: 2, Interesting

      This applies to latex allergies as well. Some hospital employees will become allergic to latex while being exposed to it repeatedly in a sterile environment.

      It's just funny. The GPP indicates that a family that works on the farm does not get allergies to many things like dust and pollen, but discounts the idea that genetics influences allergies in the least. IE, if the parents are not allergic to dust and take up a life of farming, then their children are not likely to exhibit such ailments as well.

    10. Re:Farm Workers Without Allergies by timcharper · · Score: 5, Informative

      Something interesting about allergies is that the tendency to develop allergies is inherited, but which allergies they develop don't appear to be inherited.

      I just did a research paper on the subject recently (within the last yeaar). If you can find it, here's a reference to an article about it:
      "Allergy Myths: Cleaning the Air." Saturday Evening Post 271.4 (1999): 26-28. EBSCOHost. Online. 13 Oct. 2005.

    11. Re:Farm Workers Without Allergies by dkixk · · Score: 2, Funny
      I'm no scientist but everytime I drop a large heavy object it falls faster than a small light feather. I think the conclusion is obvious.

      "Common sense is the collection of prejudices acquired by age eighteen." -- Albert Einstein

    12. Re:Farm Workers Without Allergies by norman619 · · Score: 5, Interesting

      I have a similar experience to yours. I was diagnosed as being allergic to pollen, animal dander, dust of any sort, and so on. My mom protected my brother and I from those things like crazy. When I was in the presence of a cat for example I would have a hard time breathing and my eyes would swell up and water like crazy. But guess what? After my sisters started adopting just about every stray or orphaned animal they found my reactions to them became less and less untill completely gone. At one point our house was like a petting zoo with all kinds of animals we were nursing back to health and/or rasing. The family doctor was very interested in what happened with me. At that time they were conducting a study into the theory of prolanged exposure to allergens can can help lessen or completely remove the allergic reactions. After that my parents started sending me to summer camp and again guess what? After the first 2 summers my allergic reactions to pollen were gone as well. Dust still makes me prey for death but that is the only allergy I haven't been able to shake. So yeah it's my own personal exp but I have spoken with MANY people with similar exp. Now my younger brother was not so lucky. He got the same exposure as I did but his allergies never went away. But they did decline noticably during the zoo period or our lives. But that only lasted until we left home. They have in fact gotten stronger over the years. So who knows. There needs to be more study done on this but I know in my case exposure did seem to cure me of most of my allergies.

    13. Re:Farm Workers Without Allergies by pilgrim23 · · Score: 3, Insightful

      I too was raised with bailing wire and hay... and alternating city life. One thing I did observe as a kid was the runts in the litter; they did not live. Dogs Cats Hogs...didn't matter. The pup that had the problems died off and the strong ones grew to adulthood. This "natural selection" seems missing today.. Mankind arrested his own evolution by mandating his enviornment, instead of allowing the environment to influence him. We "washed our hands" of it long ago....

      --
      - Minutus cantorum, minutus balorum, minutus carborata descendum pantorum.
    14. Re:Farm Workers Without Allergies by bogado · · Score: 2, Interesting

      Sure it does not erradicate arlegies, and in your case it seems clear that you've got them running on your family. But here it is common sense that children that were raised with animal pets have less alergies then children that had not. Some children doctors do adivise that the over sanitary environments that some mother want is bad, they even have a common joke for this. This doctors would sugest that the child need victamin "S" for "sujeira" witch is dirt in portuguese.

      --
      []'s Victor Bogado da Silva Lins

      ^[:wq

    15. Re:Farm Workers Without Allergies by binarybum · · Score: 2, Informative

      With all allergies there must be one or more exposures before the body develops the characteristic over-response, attacking harmless substances as though they really were a threat. You cannot be allergic to anything until you are exposed at least once.

      Incorrect. Cross-reactivity can make you allergic to things you've never been exposed to. Here is a lay article,

      --
      ôó
  2. You should see my bathroom by Siberwulf · · Score: 5, Funny

    If you did, you'd see why I haven't been sick in 15 years.

    1. Re:You should see my bathroom by elrous0 · · Score: 5, Funny
      I can top it. I used to live in a fraternity house. We had germs there that had learned to use tools.

      -Eric

      --
      SJW: Someone who has run out of real oppression, and has to fake it.
    2. Re:You should see my bathroom by gstoddart · · Score: 4, Funny
      I can top it. I used to live in a fraternity house. We had germs there that had learned to use tools.

      You can't count the pledges, that's not fair! ;-)
      --
      Lost at C:>. Found at C.
  3. George Carlin by BHearsum · · Score: 5, Funny

    "In my neighborhood no one ever got polio. No one, ever. You know why? 'Cause we swam in the East River. We swam in raw sewage! It strengthened our immune systems. The polio never had a prayer; we were tempered in raw shit!"

    1. Re:George Carlin by hunterx11 · · Score: 4, Insightful
      Based on that logic we should be exposing our children to Ebola, Lassa, Malaria, Rabies, Smallpox, and whatever other nasty viruses we can think of to toughen 'em up while they're still young.

      We do--it's called vaccination.

      --
      English is easier said than done.
  4. At last! by icebrain · · Score: 5, Funny

    A good reason to give my fiancee for NOT cleaning my house every weekend... I'll tell her it's good for you!

    --
    The meek may inherit the earth, but the strong shall take the stars.
    1. Re:At last! by spagetti_code · · Score: 3, Funny

      You have a girlfriend. And she cleans your house.

      Your not from around here are you?

  5. The future by Red+Moose · · Score: 3, Interesting
    A totally sanitised environment is no problem to be raised in as long you are going to continue living in it forever. Unfortunately, your OCD parents who won't let you play in a mucky garden as a kid won't be your flatmates when you are finding unwashed underclothes can stale booze in college and the real world.

    It will be no problem at all if there are moon colonies. But, as we all know there aren't (although some conspiracy theorists know there are).

    --

    Acting stupid isn't much fun when there's someone around who knows better

    1. Re:The future by x2A · · Score: 4, Interesting

      "A totally sanitised environment is no problem to be raised in as long you are going to continue living in it forever"

      Untrue. There are more problems with an untrained immune system than just the fact that it won't strengthen. At the low end of the scale are allergies, where you develop an immunoresponse to things that aren't actually dangerous, and have to start avoiding certain foods that you'd otherwise be able to eat. At the other end of the scale are autoimmune problems; where the immune system starts to attack you itself. I recall a case of a guy who's immune system was attacking his own intestines. They countered this by (yeah, I know) giving him *worms*, so that his immune system would turn against them instead, and, being occupied, allow his intestines to heal.

      You immune system also fights many other things other than just outside invaders, such as cancer, which is a lot more common than you might think, but most of the time the immune system can take care of it and so it's not a problem.

      So no, proper immuno development is essential, even if you can live in a sterilised environment all your life.

      --
      The revolution will not be televised... but it will have a page on Wikipedia
    2. Re:The future by quantum+bit · · Score: 3, Funny

      Yeah, but that's on a terraformed planet with loads of dirt and germs and trees that look just like the woods around Vancouver.

    3. Re:The future by Stephen+Samuel · · Score: 3, Interesting
      A totally sanitised environment is no problem to be raised in as long you are going to continue living in it forever.

      That may not be true. The worst case is that, if a 'bored' imune system can lead to hypersensitivity, a totally sanitised environment may lead to you getting sensitive to things like skin dust or human hair, or something (anything) in the food you're eating. Your immune system grew up in millions of years of non-sterile envirnment and so a reasonable presumption is that if it's not seeing any pathogens, it's not being dilligent enough -- so it ups the sensitivity until background noise sounds like a signal.

      The first clue that pointed me to the possibility that overly clean environments can lead to immune problems came from the difference between me and my middle sister.. We're pretty close to each other in a lot of ways, and have even managed to be mistaken for identical twins (when wearing heavy winter coats).
      Since we've moved away from home, she's kept an immaculate house -- nothing out of place and incredibly clean.

      I, on the other hand, have almost always had at least one cat and one roommate, clean on a sporadic basis, and once learned (empirically) that at least one species of ant can help eradicate a stubborn flea infestation.

      The result: I have no known alergies, and she suffers from multiple alergies. It doesn't make much sense unless a bored immune system becomes hypersensitive.

      --
      Free Software: Like love, it grows best when given away.
    4. Re:The future by Lord+Ender · · Score: 4, Informative

      Your friend probably has colitis. This is a disease that is quite common in the Western world, but does not exist at all in the "developing" world. The theory is that if your immune system is never exposed to parasites, it forgets what it is supposed to be attacking and goes after your large intestine. This will cause constant internal bleeding, mucus, and diarrhea. If it gets bad enough, you will die of malnutrition and dehydration. It usually starts happening, right out of nowhere, when you are in your 20s.

      Because nobody likes to talk about digestion, there have been very few studies of colitis or attempts to find cures. People love to raise awareness and money to fight cancer and other disease, but ignore this one because intestine problems are not polite to discuss. It's a damn shame.

      --
      A slashdotter who didn't build his own computer is like a Jedi who didn't build his own lightsaber.
  6. Polio / Middle-class diseases by eyeball · · Score: 4, Interesting

    My mother was stricken with Polio in the early 50's, just a few years before the vaccine was approved.

    Although I've never seen any literature that support this, she says Polio was known as a Middle-class disease, since the middle-class were more likely to have cleaner houses (thus not exposing babies to as many germs and developing healthy immune systems). The fact that her mother was a clean-freak before and after my mother was born may be coincidental to her contracting Polio, but I like to think they're related.

    --

    _______
    2B1ASK1
    1. Re:Polio / Middle-class diseases by lawpoop · · Score: 4, Interesting

      I took a class on the history of American medicine, and IIRC, it was pretty well established that polio was an upper-class disease.

      If you are exposed as a child, you are able to fight it off and are pretty much innoculated to it for the rest of your life. Poor people didn't have the cleanest conditions a century ago, and even middle class parents allowed their kids to mingle with the masses, in places like public swimming pools. Polio was pretty much endemic in the population, and it was only the rich kids, who weren't allowed to play with dirty urchins, who contracted the virus later in life and were unable to fight it off.

      --
      Computers are useless. They can only give you answers.
      -- Pablo Picasso
    2. Re:Polio / Middle-class diseases by Surt · · Score: 5, Informative

      A lot of people like to think things are related. That's why we have scientists and statistics. In this particular case, scientists sampling water supplies of the middle/upper classes actually discovered for a fact that polio was less prevalent in the cleaner water supplies of the middle/upper class, and that reduced exposure in early infanthood or through the mother's immune system led to more crippling cases (the greater severity of polio infection after infanthood was also well researched and understood).

      Here are a couple of resources:
      http://www.amphilsoc.org/library/mole/n/nycpolio.x ml
      http://www.pbs.org/wgbh/rxforsurvival/series/disea ses/polio.html

      So now you don't just have to like to think they were related, you can just say the link was scientifically proven.

      --
      "Who is the Journal of Quantum Physics going to believe?" --Stephen Hawking
    3. Re:Polio / Middle-class diseases by Anne+Thwacks · · Score: 2, Interesting

      Tell that to the people in Norther Nigeria who are having major outbreaks of Polio right now. Hygene is not a big preocupation there. However, the local Immams persuaded people that vaccination was a plot by westerners to eradicate Muslims.

      --
      Sent from my ASR33 using ASCII
  7. Easy remedy - Mucophagy. by Ransak · · Score: 3, Interesting
    Want to prevent all those disinfectants from weakening your immune system?


    There's an easy way!

    --
    "Powers. I have them."
  8. No shit Sherlock by ds_job · · Score: 5, Informative
    All I had to do was google for "Eat a peck of dirt" and the sixth on the list is a New Scientist page from 1998
    I was very interested in your article on the possible dangers of excessive hygiene ("Let them eat dirt", 18 July, p 26). As a child I remember being told by my mother that "you have to eat a peck of dirt before you die", a peck being two gallons. Is this another case of scientists catching up with what has been common knowledge for generations?

    If you want to fork out for the premium content you can get the full text here.
    I'm presuming that in eight years time some other publication will 'discover' this again and maybe someone will link to me instead of Susan Taylor...
  9. My Own Similar Theory... by jizziknight · · Score: 3, Interesting

    This is based mostly on BS, but interesting (at least to me) nonetheless...

    When my mom was pregnant with me, at some point she had a bad case of poison ivy. I rarely ever get poison ivy, and if I do, it's only for a couple days, and is hardly noticable. My older sister on the other hand, is quite allergic to poison ivy, and generally needs medication to control it if she gets it. I've also heard of similar stories, but can't be arsed right now to remember them. Now, we all know that a baby's immune system is related to how good the mother's immune system is. I postulate that if a pregnant woman becomes infected with any sort of non-fatal/non-life-threating disease, bacteria, virus, the baby will, as a result, be more resistant to it, if not totally immune.

    So, instead of isolating pregnant women from everything, I say we start giving them controlled infections of common sicknesses, so that their immune systems produce the atibodies, and pass them on to the baby.

    Of course, I could just be completely insane....

    --
    Everything I say is a lie. Except that... and that... and that, and that, and that, and that... and that.
    1. Re:My Own Similar Theory... by jizziknight · · Score: 4, Funny

      No, that would make her Spider-Woman, and my embryo would split into about a thousand embryos, and she would lay us in sack in the corner until we hatched. Then I would be one of a thousand Spider-Men. Let's see Doc Oc or the Green Goblin fight off THAT.

      --
      Everything I say is a lie. Except that... and that... and that, and that, and that, and that... and that.
    2. Re:My Own Similar Theory... by Chicken04GTO · · Score: 5, Funny

      Im nearly immune to the posion ivy/oaks families too. I can see it on my skin if ive been exposed, but they dont itch or bother me. Ill ask my mom if she was ever exposed to poison Ivy while preggers.

      if your theory is correct, then I wish I could go back in time and surround my mom with stupid people, because I am deathly allergic to them now.

    3. Re:My Own Similar Theory... by Erioll · · Score: 2, Funny
      if your theory is correct, then I wish I could go back in time and surround my mom with stupid people, because I am deathly allergic to them now.

      Though when you think about it, I think it'd be WORSE to not have indications that you are among such. Better to have the detector than not! ;)
  10. agree 100% by Kalinago · · Score: 3, Insightful

    I've always had this point of view all my life. I'm latin american so it's very easy to contrast fellows from extreme opposite social backgrounds in any main avenue; from what Ive seen, people that grow up in shanty towns, with no vitamins, poor diets and other problems have by average stronger, agile and toughier body types than more fortunate individuals.

    Kind of odd, but its not uncommon to read news about a young high profile kid die from an asthma fit. On the other side another one survives from four shots and a head crash in a hold up in some poor neighborhood.

    I guess this is called survival of the fittest.

  11. Clean room by tsa · · Score: 4, Interesting

    I often work inside a clean room, and once I saw a colleague of mine have a severe hay fever attack in there. Tears streamed from his eyes etc. He had to sit down for a while to recover. He told me it's the change of environment (in this case from dirty to clean air) that did it for him. Very strange.

    --

    -- Cheers!

  12. Thats why little kids eat dirt. by Cobratek · · Score: 3, Funny

    Ever notice little kids who eat dirt are healthier looking and tend to be not as scrawny as the kids with clean-freaks for parents. Ever see a toddler allowed to play outside that didnt eat dirt ? They need the bacteria for their digestive system.

    --
    DONT TREAD ON ME MOÎΩN ÎABÃ
  13. fluoridate by Anonymous Coward · · Score: 4, Funny

    Do you realize that in addition to fluoridating water, why, there are studies underway to fluoridate salt, flour, fruit juices, soup, sugar, milk, ice cream? Ice cream, Mandrake? Children's ice cream!...You know when fluoridation began?...1946. 1946, Mandrake. How does that coincide with your post-war Commie conspiracy, huh? It's incredibly obvious, isn't it? A foreign substance is introduced into our precious bodily fluids without the knowledge of the individual, and certainly without any choice. That's the way your hard-core Commie works.

    1. Re:fluoridate by rossifer · · Score: 2, Interesting
      Floride replaces iodine in the thyroid, upsetting the metabolism, causing weight gain and lethargy.

      I checked on your assertion and several reputable sources agree with you (i.e. outside of the anti-flouride crowd).

      Since flouride in food and water is almost inescapable nowadays, can the effect from flouride be overcome with higher levels of iodine in your diet or through supplements? I've heard of anti-radiation supplements that provided superdoses of iodine so that radioactive iodine from fallout wouldn't be taken up by your thyroid. Would a similar plan exclude flouride as effectively?

      This also provides a causal hypothesis for an experiment I've been conducting on myself. I've been taking sugar pills or one-a-day multivitamins using a double-blind method (and capsules to hide the differences in flavor and pill shape) to confirm or refute my subjective observation that on days when I take a multivitamin in the morning, my energy level is much higher through that day. I just checked, and the multivitamin I'm using in the test does indeed have 300% RDA of iodine (as potassium iodide). When this experiment is complete, I think I've found my next experiment...

      Regards,
      Ross
  14. Article in Mays NatGeo about this by Ponga · · Score: 2, Interesting

    http://www7.nationalgeographic.com/ngm/0605/featur e4/index.html

    The article is about allergies in specific, but is very relavant. A few researchers are claiming that because our environments are so sterile as children these days, more adults have allergies (and illness) as a result of not being exposed to certain elements (good or bad organisms, etc) as a child. Compelling read, I highly recommend it.

    -Ponga

    1. Re:Article in Mays NatGeo about this by Incadenza · · Score: 2, Insightful

      The article is about allergies in specific, but is very relavant. A few researchers are claiming that because our environments are so sterile as children these days, more adults have allergies (and illness) as a result of not being exposed to certain elements (good or bad organisms, etc) as a child. Compelling read, I highly recommend it.

      There is a difficulty with proving the theory that cleaner houses in your youth make you more suspectible to develop allergies later in your life. Fact is that there is a big genetic factor in allergies, so the reverse theory is just as likely to be true: people who develop allergies have a large likelyhood of having allergic parents who where very keen on keeping the house clean.

      Most of the studies that try to find a correlation between growing up in a hygienic environment and developing allergies do just that: finding a correlation. They do not find any evidence for either the first or the second theory, because the research was not set up to look for it. For that you will have to do studies with growing up children whose genetic compound is known, i.e. test the parents before you test the kids.

      Another problem is that the correlation between our cleaner environment (in general) and the amount of allergies (in the population) doesn't prove anything either. Lots of sicknesses are on the rise, for instance here in the Netherlands the amount of physical therapy treatments has doubled in ten years. Yet nobody in their right mind will make a connection between the need for these treatments and the cleanliness of our houses.
      Secondly, I am not so sure that our hygienic conditions are better now than 20 years ago. I know for sure my parents house was cleaner than mine is, and the same goes for most of my friends. And lots, lots of other things in our environment have changed over that last 20 years: hardly any insecticide residue on our vegetables anymore, no more CFC's in spray cans, more and more cars, more and more overweight people, no more Iodide in the bread... and endless list of correlations can be made, and a lot of these could in theory affect our natural defense system and our suspectibility to allergies.

  15. Not the mold in your refrigerator by ribuck · · Score: 3, Interesting

    As I understand it, the immune-strengthening effect doesn't come from exposure to high concentrations of pathogens, but from ongoing low-level exposure: playing in the sandpit, swimming in the river, that kind of thing.

  16. While we're all sharing anecdotes... by Zephyros · · Score: 3, Interesting

    ...I have a personal counterpoint to some of them. I grew up doing a lot of the typical outside kid things, but still ended up with some pretty bad allergies to grass and other pollens. That doesn't mean I don't agree with the article - I think it's fairly intuitive that a too-clean environment results in a weaker immune system. Just saying that the reverse isn't guaranteed.

  17. Found the article from '93 by Anonymous Coward · · Score: 2, Informative
  18. Predisposition by xstonedogx · · Score: 4, Interesting

    It could also be that those with allergies tend to move away from the farms. I wouldn't last a week on a farm without some Zyrtec.

    My sister and I grew up in the same environment. We lived in air conditioning, but spent most of our childhood playing outdoors in suburbs of Minneapolis. I have severe pollen-based allergies. If I do not have air conditioning or medication, I can wake up with my eyes glued shut from secretions, my throat can hurt like the worst strep throat you ever had, and my eyes and ears itch constantly. I am also mildly allergic to pretty much every food. My sister has no allergies of any kind.

    My family was on the farm two generations ago, and one generation ago they still worked on the farm during the summer. Some of them have allergies, some don't.

    My daughter's skin has reacted to certain foods since she was a baby.

    So, I think there are probably genetic predispositions to allergies. However, I think there may be a role for environment in those who are less severely predisposed to allergies than the members of my family.

    1. Re:Predisposition by Hentai · · Score: 4, Insightful

      So, here's an interesting theory: Pregnant women who are around allergens sometimes pass those allergens through to the developing embryo, which spontaneously aborts if it can't handle it. If this happens within the first few days of pregnancy, it'll never register as a miscarriage - she was just "a few days late".

      Thus, people who grow up in less-than-cleanroom conditions are *born* hardier, because natural selection takes out the rest of us before we're born. In ultra-hygenic areas, mothers are exposed to less potential allergens and low-grade toxins, and thus more fetuses with potential immunodeficiencies come to term.

      --
      -Hentai [in vita non pacem est]
    2. Re:Predisposition by hr+raattgift · · Score: 2, Informative

      So, here's an interesting theory

      "Hypothesis", not "theory".

      Pregnant women who are around allergens sometimes pass those allergens through to the developing embryo, which spontaneously aborts if it can't handle it

      It's unlikely.

      The developing embryo takes a few days from fertilization to implantation. This sometimes leads to light bleeding or minor cramping, and is often read as a pregnancy marker. Before this time, there is little contact between the developing embryo and the mother. Moreover, there is essentially no active/adaptive immune system in the embryo, as there is little cell differentiation. An allergic response requires mast cells or basophils.

      After implantation, a placenta is formed. The placental barrier is selectively permeable, and uses active transport to move large molecules across the barrier. The molecules involved in active transport are very protein-specific, even to the point of rejecting similar immunoglobins, most notably IgE which activates the allergic response in mast cells and basophils.

      (Rhesus incompatibility is a much more common problem and does more or less what you suggest: there can be a leakage of blood in the foetus->mother direction (ONLY!) that given an Rh+ foetus and an Rh- mother, can lead to an IgG response; immunoglobin G can cross the placental barrier and attack the Rh sites on the surfaces of foetal blood cells. Result: anaemia, jaundice, and possibly death of the foetus. Rhesus haemolytic disease was commonplace, but since the 70s an injection of passive antibodies (Rh immune globulin) into an Rh- mother quickly and throughly destroys Rh+ foetal blood cells before they can elicit an IgG response. Standard western postnatal care also involves administering RhIG to Rh- mothers after the birth of a child, to eliminate the risk of training her adaptive immune system with spillover blood from her baby (and the placenta. It is worth noting that the vast majority of sensitizing events in Rh haemolytic disease generally occur after the 28th week of pregnancy, and that the dangerous allergic response is that of the mother. So this does not really fit your hypothesis well at all.)

      Some small molecules (like ethanol) cross the barrier via diffusion; some viral particles (like CMV) actively "tunnel" through the barrier in a variety of ways. These can be dangerous to even a young foetus.

      Spontaneous abortions are sadly commonplace, and some studies using very sensitive early pregnancy tests show an incidence of 25% of fertilizations resulting in miscarriage before the 6th week.

      A great deal of study has gone into early spontaneous abortions, and about half of the embryos studied have shown chromosomal aberrations including outright misarrangements. These are thought to be caused by a fertilization involving one or two damaged gametes, rather than a structural, repeatable genetic defect in either parent. These embryos stop developing on their own most of the time, and are sometimes called "blighted ova".

      Obesity, use of NSAIDs, alcohol consumption and high caffeine intake are also associated with higher than average miscarriage rates.

      It is certainly plausible that a response to an allergen by the mother could lead to an early spontaneous abortion. This has been seen in Rh haemolytic syndrome, and other allergic repsonses could similarly attack an implanted embryo with the mother's antibodies.

      However, your hypothesis that young embryos might self-terminate in the face of an allergen is unlikely, largely because young embryos lack an active/adaptive immune system. Moreover, most of the allergens in question are highly unlikely to reach a young embryo at all because of physical disconnectedness or the filtering done by the placenta (and the rest of the mother's body too, which is an imposing physical barrier armed with its own immune system).

      Finally, as noted, misc

  19. Oblig. Carlin by milkman_matt · · Score: 4, Funny

    Reminds me of the Carlin bit:

    "The Hudson River was loaded with raw sewage. That's right, we swam in raw sewage. You know, to cool off. And back then the big fear was polio. Thousands of kids every year were dying of polio. But you know what, in my neighborhood, nobody ever got polio. No one. Ever. You know why? BECAUSE WE SWAM IN RAW SEWAGE. It strengthened our immune system. The polio never had a chance. We were tempered in raw shit.

    What are you going to do when some super virus comes along that turns your vital organs into liquid shit? I'll tell you what you're gonna do. You're gonna get sick and you're gonna die and you're gonna deserve it because you're fuckin' weak and you have a fuckin' weak immune system."

  20. Unfortunately by porkchop_d_clown · · Score: 3, Insightful

    Evidence and rational thought have very little impact on people who think things like

    "the only good germ is a dead germ"

    "bright lights deter crime"

    "second hand smoke is dangerous"

    "criminals prefer machine guns"

    in the end, people don't like scary and/or icky things and demand that "something" be done about them, even if "something" makes the problem worse instead of better.

  21. 5 second rule by Glacial+Wanderer · · Score: 2, Funny

    To think that I've had the 5 second rule backwards all these years... Note to self: let food sit on the floor for more than 5 seconds before picking it up.

  22. wonder if an analogy can be drawn with macs... by aapold · · Score: 2, Interesting

    Since their users haven't had to develop antivirus instincts, are they more susceptable to a catastrophic plague in the future?

    --
    "Waste not one watt!" - CZ
  23. Yes. by porkchop_d_clown · · Score: 2, Insightful

    And you're not the first one to notice that. There's a significant concern that because Mac users aren't in the habit of virus paranoia that they are setting themselves up for a very, very big fall.

  24. I disagree by guinsu · · Score: 3, Interesting

    I cna't say I agree with this article. I grew up in a mid atlantic state in the 80s. Our house had no a/c, so I was exposed to dust and pollen from the outdoors year round, plus I was outside playing a lot. Mom was a pretty busy person, so things like dusting and vacuuming weren't as regular as they were in other people's houses. I've been stuffed up my whole life and this past year I was tested for allergies, it turns out I am allergic to dust, mold, and various tree pollens. Basically 3 things I have been exposed to my entire life.

    1. Re:I disagree by shenanigans · · Score: 2, Insightful

      The article doesn't say that exposing you to allergens will guarantee that you do not become allergic. It says that NO exposure WILL make you allergic (or at least increase the probability.) The one does not imply the other. I believe studies have also shown that overexposure to allergens can make you allergic as well.

      Damned if you do...

  25. Too much of a good thing by ggKimmieGal · · Score: 2, Interesting

    Too much of a good thing will always be a bad thing. Just like how a little bit of dark chocolate is good for the heart, a lot is hardly good for the gut. You can't have it go both ways though. Personally, I'd rather Lysol bomb the house than share it with disease carrying bacteria.

    I used to always spend all of my time outside, but then I grew up, and now I find myself in a cubicle all of the time. Apparently playing outside from the time I was 2 till probably late middle school years did nothing to prevent allgeries that I have now. I would say I have a predisposition toward them. I have relatives who have the same types of allergies and are sick at the same times as I am. Chances are, like everything else, allergies are a combination of genetics and environment.

  26. Geeks knew this for ages by Opportunist · · Score: 2, Funny

    Ever been to a geek's home? Or seen his workspace?

    WE knew this all along! That's why we stay healthy during times when about half the company is sick. Like, say, during a football world championship.

    --
    We used to have a Bill of Rights. Now, with the rights gone, all we have left is the bill.
  27. Day Cares by garver · · Score: 2, Insightful

    My wife is 9 months pregnant, due to pop any day now. This is our first, so we've been shopping for day care centers. It seems all they want to tell us about is how everything is desanitized constantly. Shoes are not worn into the rooms. Hands are washed immediately after entering the room. Surfaces are sprayed down every few minutes. Each toy is desanitized immediately after a kid puts it down.

    I came out of the first tour and said to my wife, "it was great and the only concern I have is that it's too damn clean. My boy's going to need some dirt and filth." Not only are they hampering the kids' natural defenses, but they're also evolving the next uber-germ.

  28. Outdoors, animals and allergies by Hoi+Polloi · · Score: 2, Informative

    I've found that my animal allergies vary from animal to animal (within the same species). My previous cat would sometimes start me sneezing hard. Getting her saliva on me would trigger an especially bad reaction. My current cat however hasn't given me the slightest problem. I know my allergies are still there because they flare up around different cats or at animal shelters.

    I have some doubts about the dirt hypothosis beyond just animal allergies. I also grew up playing in the woods and being outdoors a lot. I also camp and hike a lot and drink straight out of (clean) streams. I still get bad reactions to many pollens. Maybe you have to have parasites or repeated infections as a child for this possible effect to show up.

    --
    It is by the juice of the coffee bean that thoughts acquire speed, the teeth acquire stains. The stains become a warning
    1. Re:Outdoors, animals and allergies by rk2z · · Score: 2, Informative

      That would be because most people who are allergic to cats are actually allergic to cat saliva and because cats clean themselves by licking, their dander causes allergies by proxy.

      --
      This is a sig, there are many like it, but this is mine.
  29. Sterile children = sickly adults by Old+Man+Kensey · · Score: 4, Interesting
    This makes a lot of sense to me, for intuitive, anecdotal and logical reasons:

    Intuitive: I figure your immune system is like anything else in your body -- if it doesn't get a regular workout it becomes less efficient and when you stress it, it may behave unpredictably.

    Anecdotal: I grew up playing outside a lot. My favorite thing to do was hydraulic engineering on mud-puddles. I built dams, canals, locks with gates, stirred up mud to see how it behaved, etc. I was out in the woods a fair bit, got the occasional tick (this was before Lyme disease was such a concern, and as long as you caught the ticks the same day, Rocky Mountain Spotted Fever was nothing to worry about). We had cats, our relatives had dogs, etc. To this day I have relatively little issue with allergies or illnesses of any kind. Yes, dust makes me sneeze, but it honestly puzzles me why people stampede to get flu shots every year -- I've had the flu maybe twice in my life, it sucked, it lasted about three days each time, and I got over it. People look at me like I'm nuts -- "You're not getting a flu shot? WHY NOT???"

    On the other hand, just about all the people I know with allergies, constant colds, etc. are the ones with a horror of anything that might be less than perfectly fresh and germ-free. I drink milk that's a few days past the sell-by, I eat stuff that's been in the fridge a couple days, I have lunch at greasy spoons where the kitchen staff maybe doesn't wash their hands every time they touch their own face. I don't go out of my way to find "dangerous" food or items, but neither do I avoid things that may have tiny amounts of "harmful" stuff on them like my life is at risk every time I eat a sandwich.

    Logical: I won't use antibacterial soaps unless there's no alternative. Why? Because using them indiscriminately breeds resistant bacteria. This is just logic backed up by known scientific observation of microbial evolution. It's the reason your doctor won't (or at least, shouldn't) prescribe you antibiotics every time you have a fever -- if it's not bacterial, the drugs wouldn't do you any good and would breed resistance in bacteria that aren't causing you any issues yet. Then those resistant strains would take over and now you have a problem, and it's a tough problem because the doctor has to give you massive doses, or use a different antibiotic -- and there are only so many antibiotics out there. Trying to sterilize the environment is the same thing on a grander scale.

    If more parents let their kids go ahead and, for example, chew on the cat's tail, the kid's immune system would get exposed to a few new agents (and learn to deal with them), and the cat would swat the kid who would then learn "don't chew on kitty, it hurts". That's two problems solved. Don't let them play in raw sewage, but don't keep them in a plastic bubble either.

    --
    -- Old Man Kensey
  30. Re:What is overly hygienic? Where is the story? by lawaetf1 · · Score: 4, Insightful

    Your attempt at tieing this article to some sort of anti-Western movement goes nicely with your otherwise misinformed position.
    Suggesting that "antibodies" inherited from out mother is the same thing as developing our own immune response is well... just totally simplistic.

    If I do get sick, at least I'll live. More people die in developing countries from things we can easily remedy than the other way around.

    Hopelessly facile argument. The point of the article was that auto-immune disorders (which generally don't kill you outright) are a largely Western affliction because our immune systems have not been properly calibrated. Were you to get Crohn's disease (largely Western) you would live on, sure, but you'd have diarrhea for the rest of your life and some fun stomache pains. People with Crohn's disease have been successfully treated by deliberately giving them pig whipworm eggs.. once the immune system sees a *real* threat (real to the immune system, pig whipworms can't reproduce inside us) it eases up on inflaming the intestines.
    Furthermore, it has been demonstrated that kids that grow up with pets, like a dog, have less of a chance of developing allergies then those that don't.

    Please get a clue before you start posting drivel like the above. "anti-Western rhetoric" sheesh. paranoid?

    --
    CommentBot 0.7a running with args "-module irritate,disagree -target random"
  31. If you don't use your immune system by Khyber · · Score: 2, Interesting

    You'll have a much harder time even dealing with being sick. I used to clean house for a student optometrist with two kids. She made her kids change clothes four or five times a day, wash the second they even got dirty, and I swear they must've taken four or five baths a day. We were only allowed to use Lysol, Pine Sol, Alcohol, and Acetone for cleaning around her house. She wanted it "STERILE." I told her her kids would grow up having problems. Guess what? The elest isn't even 5 years old now, and he's got practically NO immune system - he's stuck in a bubble now, most likely due to her insisting upon everything being 100% sterile.

    --
    Still waiting on Serviscope_minor to wake up to fucking reality and realize that Jessica Price isn't going to fuck him.
  32. Re:What is overly hygienic? Where is the story? by RexRhino · · Score: 2, Insightful

    I don't think it is anti-western rhetoric... they are not advocating a return to 19th century living by the 1st world.

    I think this is the reaction to anti-microbial everything for children. Kids aren't allowed to play outside unsupervised in the dirt anymore (many kids aren't allowed to play outside anymore). Soaps, baby toys, etc., all comtain special anti-microbial materials. Super antiseptic sprays are a hot seller... and no-one eats anything raw or unpasterized before.

    The over-protective parents who make sure their children are not exposed to anything are probably doing more harm than good!

  33. Re:Reminds me of a recent study by DavidHumus · · Score: 2, Interesting

    I read this in a recent issue of Science News but the link is only reachable by subscibers (20060610 issue). Here's another link: http://abcnews.go.com/Health/story?id=1993859.

  34. Re:What is overly hygienic? Where is the story? by EzInKy · · Score: 2, Insightful


    The entire premise is flawed because there is no such thing as overly hygienic.


    No, the premise is not flawed. Antibodies are produced in response to a threat so if there is no threat there are no antibodies. That is why vaccines work by introducing a small amount of threat to your body.


    Sure, if you grow up in a sealed bubble, you will likely lack antibodies for certain things. However, you will have antibodies passed onto you from your mother.


    If your mother was raised in the same sealed bubble as you she wouldn't develop antibodies to pass onto you.


    We already know that every living thing develops certain immunities/resistance in specific environments. People in certain countries develop resistance to many indigenous parasites, while vistors become seriously ill.

    If I do get sick, at least I'll live. More people die in developing countries from things we can easily remedy than the other way around.


    It depends on what pathogen infects you as to whether or not you will live. Due to the overuse of antibiotics we have created "superbugs" such as MRSA and VRE that are beginning to find there way into the general population.


    This article is just more anti-western rhetoric suggesting that the west would be better off if we were dirtier and that we should apologize for being better off than someone else. We've already gone through our development and I'm thankful to have benefitted from it.


    The article isn't anti-western, it's anti-shortsightedness. What benefits you today may not benefit the generations that follow you tomorrow.

    --
    Time is what keeps everything from happening all at once.
  35. Be careful... by LunaticTippy · · Score: 2, Informative

    I don't react to poison whatever either. My brother was the same way for years and years, but eventually developed a sensitivity to it. His doctor said that erratic large exposure to allergens can eventually produce sensitivity.
    So don't seek it out and show off like I did.

    --
    Man, you really need that seminar!
  36. Re:unfortunately... by a55clown · · Score: 2, Funny

    move to new jersey.

  37. Know what messed with my immune system? by Brianwa · · Score: 2, Interesting

    When I first started highschool I had to start waking up at six in the morning rather than sleeping in. The first half of that school year was hell - I had the same flu three times in a row, I just couldn't fight it off. I caught every virus I was exposed to. I even started having problems with some foods. Things got better as my body got more used to the sleep cycle.

  38. "clean" doesn't mean "Clean" by danskal · · Score: 2, Insightful

    It seems to be a ubiquitous misconception that "clean" means somehow pure.

    What we call "clean" often means, "covered in cleaning chemicals", or perhaps "free from stuff that is alive or was recently alive, like bacteria, house dust, cat hair etc.", or just "free from visible dirt".

    I think it's fairly common knowledge (though apparently not on slashdot) that perfumes and other chemicals are a common cause of allergies.

    So therefore it is more likely that it is the paranoid housewife's love of agressive chemical cleaners with 'lovely' fragrant perfumes, that causes allergies in those clean city homes.

    Regarding the clean room discussion - the term is also misleading: clean rooms are usually a type of laboratory, and so contain all manner of chemicals. They are usually only a low dust (or airborne particle) environment. I myself worked in a clean room, where we used nasty solvents (chloroform, benzene) for cleaning apparatus and dissolving chemicals. It would be no surprise to me if someone entering there had an allergy attack.

    My mum thought she had asthma or similar, because she would wheeze when we opened the kitchen window. The she cleared out some cupboards and threw away a load of old household cleaning solvent bottles, and the wheezing went away. The draft from the window had been wafting the solvent vapours over to the kitchen table.

    Of course, a subject like this is rarely black and white, and I am sure the argument about exposure to microbes has merit (I myself have had a bout of colitis, and was at one point was tempted by the worms treatment)

  39. Re:Perhaps you could read the EPA study yourself. by phcrack · · Score: 2, Interesting

    You mean this study? It seems to say tobacco smoke is a Class A carcinogen. Apparently, only 160,440 people in the USA died of lung cancer last year though. That means that 1.8% of all deaths from lung cancer are directly caused by second hand smoke. Then there are the 35,000 to 40,000 deaths per year from heart disease due to second-hand smoke. Of course, if you're willing to murder 3000 people per year for a habit, what's another few thousand?