Bone Hormone Linked to Obesity and Diabetes
grrlscientist writes "New research has shown that the skeletal system may be an important player in preventing obesity and type-2 diabetes in animals. This may also be true for humans, and thus represents an important development for the treatment of these health conditions. From the article: 'Not only do bones produce a protein hormone, osteocalcin (pictured), that regulates bone formation, but this hormone also protects against obesity and glucose intolerance by increasing proliferation of pancreatic beta cells and their subsequent secretion of insulin. Osteocalcin was also found to increase the body's sensitivity to insulin and as well as reducing its fat stores ... "The skeleton used to be thought of as just a structural support system. This opens the door to a new way of seeing the bones," said Dr. Gerard Karsenty, chairman of the department of genetics and development at Columbia University Medical Center in NYC, who headed the team that made the discovery.'"
It still seems that not eating massive amounts of sugar (as most Americans do) might help prevent diabetes, too.
That's what millions of lazy, overeating fat people around the world are saying right now!
I thought that was Einstein pictured...
By what name do you wish to be mourned?
that old nice way of saying "she's fat": "she's just big boned", might actually be true?
intellectual property law is philosophically incoherent. it is your moral duty to ignore it or sabotage it
I'm just big boned!
We don't have sugar over here in the US. Sugar is for our betters, gov'nah. Thank you, sir, may I have another bowl of high fructose corn syrup and strange chemicals that also appear in inedible products?
So when she says "I'm not fat, I'm just big-boned" she might actually be telling the truth.
SIG: TAKE OFF EVERY 'CAPTAIN'!!
Tagged 'boner'
Y'know what else prevents obesity and type-2 diabetes? Eating less!
Bone Hormone Linked to Obesity and Diabetes
Come on, we all know that fat people and diabetics find themselves unable to bone even when they get a rare opportunity.
You mean viagra? (Or as we scientists call it, \/1@gr@ )
At the bottom of the
Same as always. Eat less, walk more. You don't even need to work out hard, just go for a walk in the evening, and do some push-aways from the dinner table once in a while.
By far the best method of combatting obesity is exercise and "eating right". That means cut out the fats and sugars as much as possible.
But people don't want to hear that, any more than they want to hear that credit cards don't magically pay themselves off, or that blowing the trust fund on film school won't automatically get them an Oscar-winning gig in Hollywood.
We have become soft. People aren't chasing their food anymore.
Firstly, this isn't Digg, can we please not link to blogs? The original paper from Cell is here: http://download.cell.com/pdfs/0092-8674/PIIS009286 7407007015.pdf.
Secondly, this is exciting news, but not exactly surprising. The differentiation of cells starts in the bone marrow, and there are biochemical signals that start that process. It's not surprising that some of these would be in bone marrow.
Finally, must these articles always make a point to imply that obesity is cause by some random genetic/biochemical "magic bullet," instead of eating poorly and not exercising? I understand that they need funding, and implying you may be able to "cure" obesity is a great way to get it. Even so, I think there's something rather disingenious about it.
We're boned.
Also, you cannot eat pure protein; if you are eating low carb, you must eat fat. My blood pressure and cholesterol have confirmed that this isn't unhealthy as long as you aren't poisoning yourself with too much sugar and corn syrup (which is in a lot of foods you'd normally consider healthy, unfortunately.)
Brackets contain world's first nanosig, highly magnified:[.]
SCIENCE: Being a greedy, unhealthy, sedentary slob linked to Obesity and Diabeetus! ... Who knew?
Conscience is the inner voice which warns us that someone may be looking.
Boneless humans.
I've repeatedly heard it said that you would have to run for an insane amount of time to burn off the extra calories from just one cookie, so it isn't in that fashion that exercise helps with weight problems. The only alternative explanation I've heard involves endorphins and whatnot. I've suspected that it may be due to the fact that repairing the damage done to one's body during exercise is metabolically more expensive than just doing the motions, but had no idea whether this was true or not. This possibility, however, is far more interesting and direct - exercise puts stresses on the bones that may stimulate the production of a hormone that aids in the proper regulation of energy metabolism.
Kind of like how certain immune functions cease working in the absence of a gravitational field.
Granted, the root of the problem is energy intake exceeding energy expended, but until one understands better the reasons why a person would eat more than they need it is futile to tell people to just stop.
I've also wondered if part of the problem isn't that the modern, refined, carbohydrates are so concentrated. I mean, I would imagine that the human digestive system is capable of absorbing nutrients down to a certain concentration in the digestive fluids. If the calories are more concentrated, eg the food lacks fiber to give it indigestible bulk, then the body will absorb a larger fraction of the calories. So, another question I have is if it is significant to not just consider calories ingested, but calories ingested minus calories expelled.
was corn-based byproducts (corn syrup?). Most cookies, like most snacks (in box listed portions of course) are around 180 calories. I run about 1 mile at a 10% grade for just over 10 minutes to burn that. My treadmill has on of those digital counters. Changes the way I think about having a beer or buying that bag of potato chips. But I wouldn't call 1 mile insane, just a bit of a disincentive.
Quack, quack.
I'm not fat, I'm big boned!
I know this from personal experience.
Refined carbohydrates put me to sleep and give me headaches.
Unrefined carbohydrates give me gas.
Engineering tradeoffs?
Over eating and lack of exercise. Will this make Slashdot's front page?
The numbers posted are very, very wrong.
A glucose level between 70 and 140 is normal, with anything below 70 indicating hypoglycemia (with or without symptoms), and anything above 140 representing a spike.
You'll probably be unconscious (or at least wonder where you are) before you reach 40, and going above 80 is not "unhealthy".
(These numbers are in mg/dL. mmol/L numbers are slightly different -- divide by 18 to get mmol, afaik.)
> A level between 40 and 80 is healthy, anything above 80 is unhealthy
40?! You're nuts. If you're below 50, you need to get some orange juice in your body ASAP. Between 80-110 is normal (closer to 80 is better, though). In fact, from the article you linked to, "A measurement of 40 is grounds for an immediate trip to the hospital." Really low glucose levels are more immediately dangerous (easily fatal) than high ones. Consistently high ones will destroy your body in ways you don't want to think about (blindness and limb amputation is common, among many other things).
If you go above, I think, 245 or so, your body goes into 'ketoacidosis' and starts eating itself and the chemical Acetone (nail polish remover) winds up in your bloodstream. I can tell you from personal experience that this feels about as good as it sounds.
Oh please don't tell me it's Viagra!
"I'm not obese because I sit on this couch all day long and eat pizza. No. It's because [insert lame excuse here] and not my fault."
Almost all fat people, probably 99.999% of them, are fat because they eat too much of the wrong kind of foods (ie junk food) and get almost no exercise at all.
Dude, it is a simple as that. Eat what you need, not what you want.
The parent to your comment is more right than wrong. Fat people need to stop passing the blame for their 'condition'. Hell, most of the time just being overweight is the lead cause of degrading health - e.g. Diabetes.
"You obviously don't know a thing about the subject."
You obviously don't like being told it is your fault.
Dan. -- So what if it's spelt wrong, nobody's perfect
When I visited the doctor the last time they measured my waist, and said (to my great surprise) that 92 cm (36 in) is the recommended measure for men of ANY length.
More feel-good junk science to feed the rightfully low self-esteem of the Buffet Buffalo population. Many years ago a doctor candidly revealed to me that chronic pathological causes for acute Lardus Assimus account for about 2% of all cases. The rest of the up-right walking hog population is just lazy and eats too much, but doctors can't say that, at least not in public. Life experience tends to confirm this. If you want to be a pig, that's fine, but don't expect any sympathy from the healthy population.
Scruting the inscrutable for over 50 years.
The problem isn't the TV. The problem is how people watch TV, typically reclining on the comfy sofa or La-Z-Boy.
If people watched TV while doing jumping jacks, jogging in place, exercising on a stationary bike or walking on a treadmill, they would lose weight.
Actually, you are wrong but it doesn't surprise me that you said that. I'm in my mid-40's and have 12% body fat. I constantly work with my weight but few that know me consider me to be fat. My family, however, has a history of obesity and diabetes, my mother has it, my father died from it, and my siblings are becoming severely overweight. I have a great deal of experience in the matter and I see a doctor 4 times a year to do blood work.
"Dude, it is a simple as that. Eat what you need, not what you want."
When you grow up, maybe you'll have enough experience to offer and educated comment on the matter.
"You obviously don't like being told it is your fault."
Tell me it's my fault all you want. In 20 years you'll be fatter than me and the attitude will change.
and I seem to have problems with candida albicans.
(Yes, I have been tested for diabetes. Inconclusive results.)
I've been living with this more than twenty years. I don't mind the gas. My wife and kids sometimes complain. Living without simple sugars is fine with me, but the hour and a quarter workout every day to kick me into gear before work is sometimes a frustration when I would prefer spending the time on some project.
Humans only use up a small amount of energy by moving around. The problem isn't the lack of movement it's the junk which typically goes into the mouth while watching TV.
No sig today...
No, she/he is both fat and big boned.
My other SIG is a Sauer.
I'm slim, strong, BMI of 21, and an accomplished rockclimber.
Guess what, I'm 44 years old!
Grandparent is absolutely right!
I've been asked several times if I'm on a diet. Well bullshit, It's just that I don't overeat. I don't count calories, but am aware of what I eat, and don't stuff myself. Oh by the way, apart from the climbing, I also use an exercise bike about 30 minutes every day.
I will not allow myself to become like most of my age group, flabby, unhealthy whiners. I'd rather be dead!
Well now you can go back to the fridge and the couch.
Bart
I have always said that GH levels that control not only muscle and hormone levels, they also
affect bone....as per our early bodybuilders would show us due to the use of organic GH
as opposed to the synthetic used today. Organic made their bones grow, hence the big gap in their teeth, so because of this, also I would have to agree with this article as I knopw myself from personal experience using insulin, that everything is related at the molecular level to the gh our bodies produce, and which is why they give hormone therapy to obese people and also to aids victims.
...and since you've never experienced metabolic syndrome, no one has. Furthermore, you never will!
You may claim to be 44 years old, but you think and brag like a teenager.
Well maybe I'm just irritated by all these people that seem to think that its inevitable that you get fat when you get older, or that tell me that with my metabolism I can eat anything.
If I look at the amount of food that those commentators stuff into their body, they always out-eat me by a large amount. Also, the kind of stuff, the deepfried foodoid they seem to prefer is definitely not part of my diet. The funny thing; I am generally taller, and probably more muscular also, so I would need more food to keep those muscles, no ?
I don't brag, I have no reason to brag, this is my life, my body, and I like it this way. Just stop whining when you're overweight, and do something about it.
And lastly, don't sit on top of me in the bus, when you're attempting to sit NEXT to me.
There are over 2 dozen non-overeating causes known for obesity, yet bigots like yourself continue to spout your bile. It has been shown that obesity is one of the last acceptable prejudices, because it allows the well-off to look down on the poor who cannot afford gym memberships and healthy food, but have to eat the much cheaper starches, which creates insulin resistance.
This one made me smile, good one, proves that fat people can be funny: "I've never sat on a person while getting on the bus but I might make and exception in your case." Unless you're not fat ofcourse, in which case it just proves that you can be funny.
:-) I once earned some dollars, but that was in the nineties somewhere. I mostly earn guilders and euros :-)
As for your arguments; maybe my body craves less food than that of an overweight person, that still does mean one HAS to put the food in. I know my wife eats less than she would like to, and doesn't eat some of the things she'd want to, because she likes to be slender more than she likes the food. She used to be chubby by the way, and proves that being overweight can be fixed by lifestyle changes. Same for my father in law by the way.
The other thing: the obesity epidemic is worse in the U.S than anywhere else. This country at the same time has: a very sedentary carloving lifestyle; little free time; lots of eating out at fastfood places; not enough sleep for most of the population! There is obviously no genetics involved since the Americans were not overweight only 50 years ago. The connection seems obvious. Add to this the fact "low fat yoghurt" in the U.S. supermarket would be called normal yoghurt here in Holland shows that supermarkets food labelling doesn't help. Oh one more thing: have you ever considered the meaning of the "Health Food" section in the supermarket? What are they selling in the rest of the place???
As for me personally: I eat no meat, I eat no fried food, I eat no butter or margarine. I eat no candy. No fast food. If there is a low-fat variety of something, I eat that. I exercise, a lot. I sleep enough. Ofcourse I'm at a healthy weight. You won't find anyone with my lifestyle that's overweight. Simple.
Greeting and no hard feelings
Oh, I made 75kEuro last year by the way
my experience is that diet is like religion and politics - it is hard to have a meaningful discussion and nobody wants to admit they are wrong.
you want to lose weight - try the zone diet.
http://drsears.com/welcome.page
for those significantly over weight, ~50 lbs weight loss in 6 months isn't atypical. this is unlike any other diet out there - except those diets that copied it without understanding the underlying science behind it.
the former heaviest man in the world lost 430 lbs in ~ 1 year.
Robin lost 45 lbs (247 to 202) in 6 months during PBS Scientific Frontiers weight loss show.
I've lost about 1 lb per week (178.5 to 167.0 in 12 weeks - i'm just under 5' 11"). Some of that is water weight, but I've also gained significant muscle during this time frame, too. I'm sure that has offset the water weight and some extra fat loss.
i've told countless people about this diet. very few seem interested - even though an older, skiny guy *raves* about his diet and tells everyone how great it makes one feel.
my new worst days are better than my old best days.
anyway, less than 10% of the folks i tell about how great this diet is will make an effort to try it. one held out for about a year before trying it. he tried it and his ongoing acid reflux (the whole time i knew him - for 2 plus years) disappeared over night.
another lady tried it and lost 2 lbs in two weeks and was "disappointed" even though she agreed she wasn't hungry and she had more energy. i ended up leaving that company, so i'm not sure if she stayed on it or not.
another guy "kinda sorta" tries it, but isn't into it too much and has had minimal results.
in my case, i've had ongoing nerve damage for 20+ years. i stayed out of the gym for fear of flaring up my left ulnar nerve (my right was surgically repaired). after hitting 40 and realizing sleeping had become a "contact sport," i decided it was time to focus on the zone diet and start lifting weights, consequences being as they may.
as i've said, i've effortlessly lost over 11 lbs of pure fat while, at the same time, gaining significant lean muscle mass. my cardio has skyrocketed from exhaustion after 10 minutes of elyptical training to no shortness of breath after 50 minutes of elyptical training.
i'm 6 to 8 lbs of pure fat (3-4 more months?) away from a ripped six pack stomach at 40. during that time, i will pack on even more lean muscle mass.
as a kid i could get the muscle, but i couldn't rip the stomach - and i tried. as it turns out, my diet was all wrong.
i changed my diet. you claim you will.
my anecdotal evidence says theres a 90% chance you will CHOOSE to keep doing the same old fat inducing things you've been doing up until now. if so, yeah, your obesity is your fault.
you'll see my 40 plus year old ripped abs and claim it to be "good genetics."
it isn't, but the truth doesn't matter too much to those over weight because, if it did, they would take action to change their unhealthy lifestyle.
many of my good friends seem to get upset when i talk about zone diet successes. so much so, it is basically off topic because all my over weight friends are unwilling to do what i do every day (and i love doing it!) because they don't want to TAKE RESPONSIBILITY for what goes into their mouth and when. they see my results, realize it is 100% their fault and they create distance between me and them.
my anecdotal evidence indicates that, not only will most over weight folks not take action to change their state of being, they will be hostile to those who actually do change their lives and try and lend a han
We often view bones as the skeltons of the dead, but bones are amazing alive and active organs in body. The American who won then lost Tour de France last year had a dead hip joint during the race. Its was supposed to have been excruciatingly painful and most pain drugs were banned by the Tour.