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Fish Poison Makes Hot Feel Cold and Vice Versa

SoyChemist writes "Ciguatoxin causes bizarre neurological symptoms including temperature reversal, a burning sensation, and an imaginary feeling of loose teeth. It is produced by algae and accumulates in the fatty flesh of tropical fish. While traveling to the tropics, a man from England ate some bad seafood that contained the unusual poison. His story, and the tale of some unfortunate sailors of an earlier age who suffered the same affliction, appeared in the current issue of Practical Neurology and was summarized on the Wired Science Blog. Both the Wired blog and the peer-reviewed journal neglected to mention that the potent neurotoxin has been made from scratch by organic chemists."

169 comments

  1. Re:HOW MANY NIGGERS DOES IT TAKE TO CHANGE A LIGHT by daddyrief · · Score: 0, Offtopic

    You are a troll, good sir, and while my comment may not be Insightful or Funny, yours is even less so. Farewell, racist troll, and may you enjoy the trenches of Slashdot hell.

    --
    "Banking establishments are more dangerous than standing armies." -Thomas Jefferson
  2. Paradoxical Dysaesthesia by die444die · · Score: 5, Funny

    paradoxical dysaesthesia is hot.

    --
    die444die
    1. Re:Paradoxical Dysaesthesia by Anonymous Coward · · Score: 4, Funny

      I get a burning sensation that it's cool!

    2. Re:Paradoxical Dysaesthesia by It'sYerMam · · Score: 1

      Sounds cool!

      --
      im in ur .sig, writin ur memes.
    3. Re:Paradoxical Dysaesthesia by mfh · · Score: 1

      It's nawt hawt -- it's cooooold!

      It makes sense though, because sometimes something so hot feels cold and sometimes something so cold seems hot. Slow news day ftl.

      --
      The dangers of knowledge trigger emotional distress in human beings.
    4. Re:Paradoxical Dysaesthesia by Anonymous Coward · · Score: 0

      at least it's not neutral. i would like to apply some o' that on my hemmorhoids. i would rather have cold and itchy rather than hot and burning.

    5. Re:Paradoxical Dysaesthesia by Anonymous Coward · · Score: 0

      at least it's not neutral. i would like to apply some o' that on my hemmorhoids. i would rather have cold and itchy rather than hot and burning.

      According to Wikipedia it doesn't actually reverse hot and cold, it just makes cold things feel hot. So, guess you're out of luck, it would still be hot and burning, but if you put something cold on it, it would feel even hotter.

    6. Re:Paradoxical Dysaesthesia by AskFirefly · · Score: 1

      If you can't read the article, you can always wait until it shows up on an episode of "House".

      --
      I'm not a human, but I play one on T.V.
  3. Remember when... by The_Mystic_For_Real · · Score: 5, Informative

    Remember when submitters used to mark links that required payment?

    --

    _____

    Thank you.

    1. Re:Remember when... by Nullav · · Score: 4, Informative

      How the hell was this modded off-topic? The first link in the summary makes you pay to read beyond a short summary.

      --
      I just read Slashdot for the articles.
    2. Re:Remember when... by wlad · · Score: 1

      Unless you're lucky, and you are in a university, and your university has an electronic subscription to that journal. Otherwise you end up paying crazily high amounts of money per article.

    3. Re:Remember when... by nbucking · · Score: 2, Insightful

      I agree. Why isn't there a torrent site for academic papers? Lack of interest? Hopefully I spur some interest. Besides the point, why not just link us to wikipedia instead?

    4. Re:Remember when... by jez9999 · · Score: 1

      Yeah. That site is stupid. Why don't they just put up some ads? The readers from here will obviously go with the spirit of the site and not block the... oh, wait.

    5. Re:Remember when... by fireforadrymouth · · Score: 1

      So you'd like a tracker for academic papers (and related works, I assume) but you would be happy with just the wiki entry? Insightful my ass

  4. Poison is bad... by psychicsword · · Score: 0, Redundant

    So since when is poison causing bodily harm and unusual feeling news?

    1. Re:Poison is bad... by ScrewMaster · · Score: 1

      Yes, and in other news cyanide poisoning causes general weakness, confusion, bizarre behavior, coma and death! Acetaminophen poisoning can cause nausea, vomiting, poor appetite and total renal failure!

      Exciting, isn't it? No?

      --
      The higher the technology, the sharper that two-edged sword.
    2. Re:Poison is bad... by Headcase88 · · Score: 1

      It makes cold feel like hot and vice versa. Given that scientists can make it from scratch, if they can get rid of the other side-effects, a new illegal drug could be hitting the street (though maybe some drugs can already do this).

      --
      "When the atomic bomb goes off there's devastation...but when the atomic bong goes off there's celebraaaaation!"
    3. Re:Poison is bad... by Mr2cents · · Score: 1

      Temperature reversal and a loose teeth feeling? This news will have no obvious effect on society whatsoever. That is, until april 1st arrives...

      --
      "It's too bad that stupidity isn't painful." - Anton LaVey
    4. Re:Poison is bad... by orclevegam · · Score: 2, Interesting

      It makes cold feel like hot and vice versa.

      According to wikipedia it doesn't. It makes cold things feel hot, but not the other way around.

      Symptoms of Ciguatera poisoning
      --
      Curiosity was framed, Ignorance killed the cat.
  5. beowulf cluster by sh3l1 · · Score: 0, Offtopic

    Wow! Imagine what a beowulf cluster of those would feel like!

    --
    Help Me! I'm trapped in the tubes! Oh noes! Here comes a internet!
  6. Honeymoon by Anonymous Coward · · Score: 0

    Bad time for bad fish.

  7. Cool! by sahar176 · · Score: 4, Funny

    Errr I mean...Hot!

  8. Hmm by evilviper · · Score: 5, Funny

    Ciguatoxin causes bizarre neurological symptoms including temperature reversal,

    Ah yes, good old XNOR poison... It's been a long time old friend.
    --
    Slashdot gets worse every day... Pipedot: News for nerds, without the corporate slant
    1. Re:Hmm by MichaelSmith · · Score: 2, Funny

      Ah yes, good old XNOR poison

      Wouldn't that be NOT poison, or is that something else?

    2. Re:Hmm by evilviper · · Score: 1

      Wouldn't that be NOT poison,

      Yes that's much closer to accurate, but you'll sound awfully stupid talking about "not poison".
      --
      Slashdot gets worse every day... Pipedot: News for nerds, without the corporate slant
    3. Re:Hmm by Anonymous Coward · · Score: 0

      Wouldn't that be NOT poison, or is that something else?
      If it's NOT poison, then clearly it MUST be something else.
    4. Re:Hmm by xPsi · · Score: 1

      A XNOR temperature poison would be one that made you and your friend feel both hot or both cold after eating the same fish. Sort of a subtle effect for a poison.

      --
      i\hbar\dot{\psi}=\hat{H}\psi
    5. Re:Hmm by Anonymous Coward · · Score: 0

      maybe you meant to say !NOT poison. better patent that before Apple implements iNOT poison.

    6. Re:Hmm by I+Like+Pudding · · Score: 2, Funny

      Yes that's much closer to accurate, but you'll sound awfully stupid talking about "not poison".

      Yeah, and universities are going to be throwing honorary doctorates at you for talking about "XNOR poison". Then again, people tell me I see things only in black and white.
    7. Re:Hmm by Dread_ed · · Score: 1

      I was wondering if some masochists produce this stuff internally.

      --
      When the only tool you have is a claw hammer every problem starts to look like the back of someone's skull.
  9. Ciguatera is Common knowledge by waimate · · Score: 5, Informative

    C'mon, this is common knowledge among people who hang around the pacific. If you catch a large fish, don't eat the whole thing... eat some, and share around to dilute the risk. People have known this for over 30 years. Large fish have higher risk just because they are older.
    http://en.wikipedia.org/wiki/Ciguatera

    1. Re:Ciguatera is Common knowledge by ianalis · · Score: 5, Funny

      Share it... for mutually assured destruction :)

    2. Re:Ciguatera is Common knowledge by Anonymous Coward · · Score: 0

      I like how this is in the wikipedia article:

      "Severe cases of ciguatera can also result in cold allodynia, which is a burning sensation on contact with cold (commonly incorrectly referred to as reversal of hot/cold temperature sensation)."

    3. Re:Ciguatera is Common knowledge by Otter · · Score: 4, Interesting
      It's been known to Europeans for hundreds of years, and presumably to natives for much longer. (I had a very mild case in Belize a few years ago, from a barracuda.)

      Incidentally, for those wondering why the synthesis of this is newsworthy, check out the structures of this and similar marine toxins. The synthesis of palytoxin, at the bottom, supposedly sent a number of grad students and postdocs to the hospital, as its intermediates are also insanely toxic.

    4. Re:Ciguatera is Common knowledge by m2943 · · Score: 1

      Ah, so you got it from Agnes?

    5. Re:Ciguatera is Common knowledge by Sethb · · Score: 4, Interesting

      Yep, I was in Fiji in July, and they served some fish at our resort that was poisoned. I didn't eat any, my mom ate a small bit, but was fine. The resort owner and one other guest were quite ill for days, and their cat that ate the leftovers nearly died. Apparently there's no way to tell if the fish is infected, and cooking it doesn't destroy the toxin.

      --
      When in danger or in doubt, run in circles, scream and shout. --Robert A. Heinlein
    6. Re:Ciguatera is Common knowledge by Anonymous Coward · · Score: 0

      That's it. I'm never buying Seagate harddrives again.

    7. Re:Ciguatera is Common knowledge by ResidntGeek · · Score: 1

      There's a pretty interesting article about synthesis of brevotoxin and similar structures in Science from a month or so ago. Volume 317 (31 August 2007), pp. 1189-1192, "Water near pH 7 facilitates a series of ring-opening reactions that yield a complex toxin produced in red tides, a reaction that has proven elusive in organic solvents." I'd urge chemically-minded /.ers to read it. There's also a more layman-oriented summary in Nature's News & Views section in the most recent issue.

      --
      ResidntGeek
    8. Re:Ciguatera is Common knowledge by grcumb · · Score: 1

      If you catch a large fish, don't eat the whole thing... eat some, and share around to dilute the risk.

      Here in the South Pacific, we actually give a little to the nearest dog or cat, then watch them to see if they show any ill effects. Not kind, but better than the alternative, which is months of discomfort and real pain.

      People have known this for over 30 years.

      I think you mis-spelled '3000'. 8^)

      Large fish have higher risk just because they are older.

      Not exactly. Large fish are more risky because the poison concentrates in them. This is not necessarily a function of age, but of the fact that tiny fish have tiny concentrations of the toxin. They get eaten by small fish, who develop concentrations orders of magnitude larger, who get eaten by the big ones, who develop really dangerous concentrations.

      Note also that this toxin only appears in reef fish. Deep water fish are perfectly safe to eat.

      --
      Crumb's Corollary: Never bring a knife to a bun fight.
    9. Re:Ciguatera is Common knowledge by meatspray · · Score: 1

      No NO, it's perfectly safe to buy a Seagate hard disk, just make sure you don't eat the whole thing... /having MASH flashbacks

    10. Re:Ciguatera is Common knowledge by Domo-Sun · · Score: 1

      Wow. Fascinating. What were your symptoms, how long in duration, and do you have recurrences or "flashbacks"?

    11. Re:Ciguatera is Common knowledge by BillX · · Score: 2, Funny

      And to avoid your friends thinking you're loony toony.

      Without sharing:
      "Oww, this fish is too piping hot to eat!" - You
      "Umm, are you going crazy? This dish is served cold." -Everyone Else

      With sharing:
      "Ack, this shit's too hot!" - You
      "Right on brother." - Everyone

      --
      Caveat Emptor is not a business model.
    12. Re:Ciguatera is Common knowledge by zooblethorpe · · Score: 1

      C'mon, this is common knowledge among people who hang around the pacific. If you catch a large fish, don't eat the whole thing... eat some, and share around to dilute the risk. People have known this for over 30 years. Large fish have higher risk just because they are older.

      Not just the pacific -- it's also common knowledge in the Caribbean. The rule of thumb there is that you don't eat shallow-water fish that's grown bigger than a dinner plate, as the bigger (and older) they get, the more the toxin has concentrated in their tissues. Fish higher up the food chain are also more dangerous -- the higher order the predator, the more concentrated the toxin. Barracuda are generally avoided as food for this very reason. Apparently the microorganisms that produce the toxin stay near the surface where it's warmer, so deep-water fish are supposed to be safe.

      Cheers,

      --
      "What in the name of Fats Waller is that?"
      "A four-foot prune."
    13. Re:Ciguatera is Common knowledge by Otter · · Score: 2, Interesting

      I just had the nausea and diarrhea, along with chills. None of the really freaky symptoms like they talk about here, or the long term recurrences. Like I said, it was a very mild case. The restaurant owner followed the OP's logic and slightly poisoned 20 people instead of badly harming one or two.

    14. Re:Ciguatera is Common knowledge by Anonymous Coward · · Score: 0

      This sounds like the logic used by the mortgage industry... don't eat the whole mortgage, divide it up and rate it AAA!!!

    15. Re:Ciguatera is Common knowledge by Hoi+Polloi · · Score: 1

      It is only a matter of time before backpacking teenagers test it out for fun. "Dude! This match feels cold! And this ice cube feels hot...dooood..."

      --
      It is by the juice of the coffee bean that thoughts acquire speed, the teeth acquire stains. The stains become a warning
  10. About the journal this appeared in... by mdenham · · Score: 3, Funny

    ...would "Practical Neurology" be where you go if you're planning on having a drinking buddy do your brain surgery?

    1. Re:About the journal this appeared in... by sadangel · · Score: 4, Funny

      You insensitive clod! My drinking buddy *is* a world famous neurosurgeon!

    2. Re:About the journal this appeared in... by ColdWetDog · · Score: 1

      ...would "Practical Neurology" be where you go if you're planning on having a drinking buddy do your brain surgery?

      No, that would be Practical Neurosurgery. Neurosurgeons DO things. Neurologists THINK about doing things, if only they knew enough about the nervous system to actually Do Anything. But they don't. So they just tell you that you have some nasty problem, confusingly couched in a pseudo-Latin derivative. Then they bill you.

      Surgeons of all flavors live by the creed "Often wrong, never in doubt" - so they're much more apt to muck around Where They Don't Belong.

      All in all, it would be better if your buddy stuck to neurology - keep him away from the scissors.

      --
      Faster! Faster! Faster would be better!
  11. So, ... by Anonymous Coward · · Score: 0

    the Japanese Agriculture Ministry is not in charge of gundam but they apparently are responsible for the synthetisis of imaginary loose teeth inducing poison.

  12. old and forgotten memes... by fph+il+quozientatore · · Score: 1

    Sir, if we invert the polarity of the brain receptors we can create a quantum power surge that will destroy the pirate ship. I just need these algae.

    --
    My first program:

    Hell Segmentation fault

  13. Where to order? by clarkkent09 · · Score: 5, Funny

    The article failed to mention where can I get some of this poison? I need to cut down on my heating bill this winter.

    --
    Negative moral value of force outweighs the positive value of good intentions.
    1. Re:Where to order? by artifex2004 · · Score: 5, Interesting

      The article failed to mention where can I get some of this poison? I need to cut down on my heating bill this winter.


      Ethanol is commonly known to give feelings of warmth, ; in fact, the movie A Time For Drunken Horses is so named because the winter weather is so harsh that the only way the Iranian Kurds can get horses to work is to give them liquor.
    2. Re:Where to order? by jellomizer · · Score: 1

      But would it be better used for actually heating your home?

      --
      If something is so important that you feel the need to post it on the internet... It probably isn't that important.
    3. Re:Where to order? by iknownuttin · · Score: 5, Funny
      The article failed to mention where can I get some of this poison? I need to cut down on my heating bill this winter.

      This is nice and everything, but I want know what the hell is my wife taking that makes her cold even when I'm sweating bullets!

      --
      I prefer Flambe as apposed flamebait.
    4. Re:Where to order? by evilviper · · Score: 2, Informative

      Ethanol is commonly known to give feelings of warmth

      With the pleasant trade-off of causing death by hypothermia instead...
      --
      Slashdot gets worse every day... Pipedot: News for nerds, without the corporate slant
    5. Re:Where to order? by Anonymous Coward · · Score: 0

      Heating bill? Winter? Heck, I want some to take to WORK! I live in a state that is habitable only because of air conditioning, so what do employers do? They burn ungodly amounts of energy trying to make the workplace feel like outdoor Minnesota in January.

      It's supposed to make people "productive", but in actuality I spend more time contemplating setting the furniture on file than I do thinking about work. Or roasting the overweight people who go around saying "you can always put more clothes on" over a slow fire until all their fat renders out. My fricking NOSE is so cold it hurts. Try wearing clothes on that! Try typing with mittens on.

      Hey, if I wanted Minnesota, I'd LIVE in Minnesota! Put this poison on the market and I'll buy a caseload!

    6. Re:Where to order? by The-Bus · · Score: 1

      It's pretty clear to me: Your wife is a fish.

      --

      Small potatoes make the steak look bigger.

    7. Re:Where to order? by pla · · Score: 4, Informative

      Ethanol is commonly known to give feelings of warmth

      Except, it doesn't just make you feel warm - It reduces your body's natural tendancy to hoarde blood in your core when the outside temperature drops, thus actually warming your skin and periphery.

      Of course, on the down side, with warmer skin you lose heat faster, and when your core temperature drops a few degrees, you go into hypothermia (and to make matters worse, with a few drinks in you, you might not notice until too late).

    8. Re:Where to order? by shoemilk · · Score: 1

      Stop lying, this is slashdot! You don't have a wife!

    9. Re:Where to order? by ColdWetDog · · Score: 1

      The article failed to mention where can I get some of this poison? I need to cut down on my heating bill this winter.

      Move to a tropical climate. Solves both problems.

      --
      Faster! Faster! Faster would be better!
    10. Re:Where to order? by dasunt · · Score: 1

      Of course, on the down side, with warmer skin you lose heat faster, and when your core temperature drops a few degrees, you go into hypothermia (and to make matters worse, with a few drinks in you, you might not notice until too late).

      What's the cutoff for that?

      Let me explain: There's a range of air temperatures where my body won't suffer from hypothermia, presumably since it can regulate how much heat it produces and loses.

      When temperature gets too low, my body can't produce enough eat, and ergo, hypothermia.

      But is there a temperature range where my body could produce more heat if it is needed, but due to evolutionary pressures to conserve energy, starts to reduce blood flow to the extremities? If so, drinking would warm oneself up without making one at risk for hypothermia.

    11. Re:Where to order? by Anonymous Coward · · Score: 0

      Kinda depends on what your wearing, dontcha think?

    12. Re:Where to order? by Kreigaffe · · Score: 1

      Fortunately, the condition known as "fightin' drunk" not only makes you FEEL warmer, but also often leads to strenuous activity, such as.. fightin'. With feelings of fatigue numbed, it's entirely possible to ACTUALLY warm yourself, and keep your core temperature up, by drinking!

      I should sell a book on surviving the cold winter months in 3 easy steps. Drink! Fight! Fuck! It's what humans have done for..... however long we've been making alcohol!

      --
      ... still waiting for this free-as-in-beer free beer I keep hearing about. :|
    13. Re:Where to order? by darkmeridian · · Score: 1

      I know this is a joke, but one of the final effects of hypothermia is a feeling of complete warmth that causes its victims to strip down in the bitter cold and freeze to death. It's called paradoxical undressing. Drinking also makes you feel warmer than you actually are; that's probably why so many homeless alcoholics freeze to death during a cold snap. Anyone drinking to stay warm probably shouldn't.

      --
      A NYC lawyer blogs. http://www.chuangblog.com/
    14. Re:Where to order? by fractoid · · Score: 1

      Not to mention that alcohol is very energy-rich in and of itself. The combination of copious alcohol, and the vigorous activity it promotes, may well result in better survival rates.

      Someone hail me a beer scooter! :)

      --
      Rampant carbon sequestration destroyed the Dinosaurs' tropical paradise. I'm here to help repair the damage.
    15. Re:Where to order? by ignavus · · Score: 1

      "I want know what the hell is my wife taking that makes her cold even when I'm sweating bullets!"

      That's odd, she's not cold with me.

      --
      I am anarch of all I survey.
    16. Re:Where to order? by Hoi+Polloi · · Score: 1

      The body loses the ability towards the end to control the body's circulatory system and all of the blood that was being shunted to the core suddenly rushes back to the surface and limbs causing the heat flush. They once found a kid who died near Mount Washington in a storm who had opened up his sleeping bag before he died because of this.

      --
      It is by the juice of the coffee bean that thoughts acquire speed, the teeth acquire stains. The stains become a warning
    17. Re:Where to order? by Hoi+Polloi · · Score: 1

      If you are in a situation where there is a chance for hypothermia I'd say you shouldn't be getting yourself intoxicated no matter what.

      --
      It is by the juice of the coffee bean that thoughts acquire speed, the teeth acquire stains. The stains become a warning
  14. Botete by photomonkey · · Score: 2, Interesting

    In the Sea of Cortés (Golfo de California), there is a fish known by locals as the 'botete'. It is a type of puffer fish. It causes exactly this kind of problem.

    Very interesting the way neurotoxins work...

    --
    Message contains 1 attachment: spam.gif
    1. Re:Botete by ZwJGR · · Score: 1

      If I remember correctly certain fungal toxins cause temperature inversion...
      I don't know about a feeling of loose teeth though.
      In general with fungals its some combination of nausea, dehydration, convulsions, vomiting, delirium, thirst, coma in some cases, etc. etc. and/or death if untreated, in 8-24 hours...

      Isn't nature great :)

      --
      There is no psychiatrist in the world like a puppy licking your face - Ben Williams
    2. Re:Botete by commodoresloat · · Score: 1

      Mmmmmm.... Fugu!!

    3. Re:Botete by photomonkey · · Score: 1

      I would suppose that the toxin either dehydrates soft tissue (gums) OR that a change in blood pressure can cause the mouth to throb.

      --
      Message contains 1 attachment: spam.gif
    4. Re:Botete by bckrispi · · Score: 1

      +1 Obscure Simpsons reference.

      --
      Xenon, where's my money? -Borno
  15. French? by youthoftoday · · Score: 3, Funny

    Fish poisson?

    --
    -1 not first post
    1. Re:French? by wboelen · · Score: 2, Funny

      Probably poison de poisson ;)

    2. Re:French? by youthoftoday · · Score: 1

      bouillon de poisson?

      --
      -1 not first post
    3. Re:French? by Anonymous Coward · · Score: 1, Funny

      Un poisson empoisonné?

    4. Re:French? by SloWave · · Score: 1

      Those pesky pesces

    5. Re:French? by Anonymous Coward · · Score: 0

      In Germany these fish are a popular gift.

    6. Re:French? by Anonymous Coward · · Score: 0

      This recent expansion of my French vocabulary has left me full of uncertainty and doubt. Were my half a year of statistics spent mostly on learning cleverly camouflaged techniques for distributing fish?

  16. Nice curiosity, but what are the applications? by Opportunist · · Score: 4, Insightful

    It would be great if we found a way to selectively "switch" some receptors. Like, when people suffer from burns to ease their pain. Or maybe in a deodorant that tells your skin it's freezing so you don't sweat in the first place.

    The former I'm not too sure about (whether it works or is even a good idea), the latter sounds silly to me, so what could we make out of that? I'm usually not someone asking for applications for a discovery to be "useful", but this is intriguing. Anyone got an idea what to do with that?

    --
    We used to have a Bill of Rights. Now, with the rights gone, all we have left is the bill.
    1. Re:Nice curiosity, but what are the applications? by Tim+C · · Score: 1

      Or maybe in a deodorant that tells your skin it's freezing so you don't sweat in the first place.

      What, you don't have antiperspirants in your country already?

    2. Re:Nice curiosity, but what are the applications? by Opportunist · · Score: 1

      Sure, but wouldn't it be interesting to get a "cool and fresh" feeling through poison? :)

      --
      We used to have a Bill of Rights. Now, with the rights gone, all we have left is the bill.
    3. Re:Nice curiosity, but what are the applications? by Abeydoun · · Score: 3, Informative

      As a matter of fact, that's what methanol does. One of it's characteristics is to selectively stimulate the cool-feeling receptors of your skin while leaving practically everything else alone. And on the other hand, there's capsasin, everyone's favorite ingredient in salsa.

      --
      The only consistency in life is the lack thereof
    4. Re:Nice curiosity, but what are the applications? by Abeydoun · · Score: 2, Informative

      urgh... meant to say menthol, not methanol. Bah, guess that's what happens when you skip a night of sleep.

      --
      The only consistency in life is the lack thereof
    5. Re:Nice curiosity, but what are the applications? by Jesus_666 · · Score: 4, Funny

      Awesome! I can't wait to read this on the back of deodorant spray cans:

      PoisonCorp(TM) Cool&Fresh(TM) dedorant will give your skin a cool and fresh feeling and will prevent sweating for up to twenty years.

      Known possible side effects include prickling of the skin, headaches, numbness, diarrhea, vomiting, dehydration, hyperthermia, hallucinations, lung failure, kidney failure, cardiac arrest, an atypical form of Parkinson's disease, coma and death.

      Not to be taken orally. Keep out of the reach of small children.

      Warning: PoisonCorp(TM) Cool&Fresh(TM) dedorant is known to build up in the groundwater and in animals. Any object that has been in direct contact with PoisonCorp(TM) Cool&Fresh(TM) dedorant at any point as well as the remains of persons, cremated or not, who have used PoisonCorp(TM) Cool&Fresh(TM) dedorant at any point may not be disposed of normally and must be handed over to the Environmental Protection Agency as per the Comprehensive Environmental Response, Compensation, and Liability Act ("Superfund Act") of 1980.

      --
      USE HOT GRITS WITH STATUE OF NATALIE PORTMAN (NAKED AND PETRIFIED)
    6. Re:Nice curiosity, but what are the applications? by Anonymous Coward · · Score: 0

      I don't wear deodorant, you insensitive clod! (I do shower though - with soap even.) There's just something that bugs me about blocking natural body functions...

    7. Re:Nice curiosity, but what are the applications? by collectivescott · · Score: 1

      Yeah, they do this already: http://www.botoxseveresweating.com/ "Botox: Not only for your face"

    8. Re:Nice curiosity, but what are the applications? by KillerBob · · Score: 1

      What, you don't have antiperspirants in your country already?


      Most antiperspirants use either Aluminum Chloride, Aluminum Nitrate, or some other Aluminum-based salt to trick the body into not sweating. Some people, myself included, are allergic to Aluminmum, and applying a salt containing it to the skin will cause profuse sweating.

      Now... a deodorant stick that uses this kind of property to trick the body into thinking it's cold and not sweating in the first place could be called an antiperspirant, but the kind you're talking about isn't an option for everybody.
      --
      If you believe everything you read, you'd better not read. - Japanese proverb
    9. Re:Nice curiosity, but what are the applications? by wronskyMan · · Score: 1

      Methanol can also invert light receptors - everything goes dark when you go blind after drinking it.

      --
      --- You shall know the truth, and the truth shall make you mad- Neal (not Cowboy) Boortz
    10. Re:Nice curiosity, but what are the applications? by BillX · · Score: 1

      Icy to dull the pain, hot to relax it away?

      --
      Caveat Emptor is not a business model.
    11. Re:Nice curiosity, but what are the applications? by Domo-Sun · · Score: 1

      Why use poison if you can just mint flavor everything, like the toothpaste companies do to everything.

    12. Re:Nice curiosity, but what are the applications? by Domo-Sun · · Score: 1

      "Icy to dull the pain, hot to relax it away?"

      And poison to feel like crap for 20 years.

    13. Re:Nice curiosity, but what are the applications? by Opportunist · · Score: 1

      But your armpits don't stink! Ain't that worth the risk?

      Before you answer, just ponder for a moment the lengths people go and the risks for their health they take to appear "pleasant".

      --
      We used to have a Bill of Rights. Now, with the rights gone, all we have left is the bill.
    14. Re:Nice curiosity, but what are the applications? by alexo · · Score: 1

      urgh... meant to say menthol, not methanol. Bah, guess that's what happens when you skip a night of sleep.

      I guess the people that moderated it "informative" skipped a whole week.
    15. Re:Nice curiosity, but what are the applications? by ShatteredArm · · Score: 1

      Do they have antiperspirants without Alum yet? I don't like my armpits turning yellow. (I think it's the Alum that makes them turn yellow, anyhow...)

  17. meanwhile by Swampash · · Score: 1

    the potent neurotoxin has been made from scratch by organic chemists ...who are at this moment being transported to Guantanamo Bay for "re-education".

  18. Loose teeth? Englishman? by dissolved · · Score: 4, Insightful

    Given the state of our NHS and the mythical availability of dental treatment, I wouldn't put the blame for any feeling of loose teeth down to poison alone...

    1. Re:Loose teeth? Englishman? by demonlapin · · Score: 1

      I've always wanted to know - and you gave the opening to ask - why don't more people just go to a private dentist? It's not terribly expensive - I pay full price here in the US, and it's around $100 for full exam and cleaning.

    2. Re:Loose teeth? Englishman? by KillerBob · · Score: 1

      Supply and demand. It's $160 at my dentist for the same service, and that's in Canadian dollars, which are worth more than Yankee bucks.

      --
      If you believe everything you read, you'd better not read. - Japanese proverb
    3. Re:Loose teeth? Englishman? by Anonymous Coward · · Score: 0

      I had an excellent private dentist when I was in England - cost something like 100 pounds a year. It was well worth it - and the place was completely full all the time, so basically its a case of... If you build it, they will come."

    4. Re:Loose teeth? Englishman? by dissolved · · Score: 1

      I do see a private dentist if I can't get NHS treatment. Thing is you pay 22%-40% of your income in taxes to pay for NHS treatment but you can seldom get it. I think this is the reasoning behind the stampede for registration at NHS clinics. I also think the whole "British Teeth" thing is a bit overplayed these days. We're not *that* bad :-)

  19. chemical synthesis by edittard · · Score: 1

    Someone must have patented a method for getting atoms to rearrange into clusters (hereinafter referred to as molecules) of a desired composition with test tubes and bunsen burners and stuff...

    --
    At the bottom of the /. main page it says 'Yesterday's News'. Well they got that right.
  20. oh my god by rpillala · · Score: 1, Funny

    Don't give the Bush administration any more ideas.

    --
    When the axe came to the forest, the trees said, "Look out - the handle was once one of us."
  21. Breaking News by schraitle · · Score: 1

    US Coast Guard has stopped a shipment of fish fat from being delivered off the coast of Florida. The smugglers claimed to be mere fishermen, but when one of them was burned by a splash of water, authorities became suspicious.

  22. LSD by nurb432 · · Score: 4, Funny

    Can do this too. And cheaper.

    --
    ---- Booth was a patriot ----
    1. Re:LSD by Anonymous Coward · · Score: 0

      Consistently? I thought so.

      Why don't you go drop acid then you damn libertarian hippie.

      Captcha: maverick

    2. Re:LSD by TapeCutter · · Score: 1

      Yeah but with LSD your teeth don't just feel loose, they jump out of your head and run around the room laughing at you.

      --
      And did you exchange a walk on part in the war for a lead role in a cage? - Pink Floyd.
    3. Re:LSD by jd · · Score: 1

      Whereas if you mix the fish poison with LSD and those magic mushrooms Holland is banning?

      --
      It's a small world and it smells funny; I'd buy another if it wasn't for the money; Take back what I paid (SoM)
    4. Re:LSD by fractoid · · Score: 1

      Well, then you can tell us whether the snozzberries are warm or cold, as well as whether they taste like snozzberries.

      --
      Rampant carbon sequestration destroyed the Dinosaurs' tropical paradise. I'm here to help repair the damage.
  23. Oblig Dyslexic: Weird Science by shashark · · Score: 1

    "... summarized on the Wired Science Blog." or Weird Science Blog, going by the weird scientific articles being posted on there.

  24. USSR Fish Poison by Spookticus · · Score: 2, Funny

    In soviet russia, unusual fish poison that makes you feel hot as cold and cold as hot makes you feel hot as hot and cold as cold.

    1. Re:USSR Fish Poison by kaizokuace · · Score: 1

      In Soviet Russia, poison warm you!

      --
      Balderdash!
  25. Re:Umm...Psychoactive drugs? by Bucc5062 · · Score: 4, Insightful

    This isn't "News for Nerds", this is news for the guy who sells you pot.

    Why is the assumption always that /. is only for computer nerds. I've met a few scientists in other fields in my time and they seem just as "nerdy" as my fellow programmers. Some may even stay in the basement of their Mom's house chopping up body parts or mixing toxic chemicals together.

    Either you are new to /. and miss the point that even politics, toxins, and robots can effect "nerds/geeks", you have a secret phobia against fish, or miss the point of just how cool this article is to the community at large.

    Personally, I have enjoyed the odd view some of my fellow /.'ers have posted regarding this article. I also appreciate the news so that when I travel to the Pacific someday, I will take care eating fish.

    Enjoy the moment, we have so few.
    --
    Life is a great ride, the vehicle doesn't matter
  26. That's not as bad as.... by OneSmartFellow · · Score: 1

    ....Rectal Cranial Inversion. Sadly, most people already suffer from the latter without knowing.

  27. The next recreational drug? by davidwr · · Score: 1

    Now that it's been synthesized, will this become the next recreational drug in countries where it's legal?

    --
    Knowledge is how to play a game, intelligence is how to win, wisdom is knowing what game to play.
    1. Re:The next recreational drug? by Anonymous Coward · · Score: 0

      Probably not, it's more fun when it's illegal.

  28. amusing? by m2943 · · Score: 2, Interesting

    described the amusing case in the October issue of Practical Neurology

    Amusing?

    including temperature reversal, intense pruritus and increased nociception [...] improved over a period of 10 months

    This sounds very unpleasant. This might be amusing if it happened to Osama, but otherwise, this isn't something you'd wish on someone's dog.

  29. I knew I was right when I was 5... by krycheq · · Score: 1

    and I tried to tell my mom!

    Poissons = Poison

    1. Re:I knew I was right when I was 5... by Anonymous Coward · · Score: 0

      No, you fool!

      You just used the assignment operator. Instead of testing Poissons equality with Poison you ASSIGNED the value Poison to Poissons. You've places the lives of countless statisticians at risk. They will now have to use protective gloves whenever analyzing random distributions.

      I hope you're proud of yourself.

  30. What doctors do these folks go to? by xPsi · · Score: 2, Insightful

    I always enjoy reading stories like this where some interesting or subtle medical effect is at work. It evokes images of proactive doctors working closely with patients to really understand their problems and symptoms, delving deep into the pathology of whatever condition they are complaining about. But in my experience, typical doctors in the US are not in the least bit interested in actually studying medical conditions that come across their desk (or, more appropriately, forwarding the situation on to a research pathologist). They usually have a pragmatic "if it hurts when you do that, then don't do that" or "if you are bleeding, I can help you but otherwise you are on your own" attitude. If I came to my doctor and said "hot and cold are reversed after I ate some shellfish," I'm pretty sure the response would be "then don't eat it next time, it just happens to some unlucky people. Drink some water, get some rest, it will go away in a month. That will be $200. Next!" In fact, I'm pretty sure the discussion of shellfish wouldn't even come up because the conversation never seems to get as far as that. I speak with some experience here because I have suffered from a couple of unusual (but not deadly) medical conditions. The response is always the same: "some unlucky people just have that and we don't know why. Have a nice day." Is it something I ate? Something I did? Something in my physiology? Something genetic? "We don't know. Have a nice day." But wouldn't they want to know? I blame this intellectual laziness on HMOs, which tend to put otherwise motivated doctors in a terrible bind. If a doctor wants to do some test to study an unusual condition, they have to justify it to a big business that will determine if the procedure was "necessary." If the procedure is deemed unnecessary but is done anyway, then the patient gets stuck with the bill. If the patient defaults, then the doctor must pay out of pocket. Such procedures are usually very expensive and doctors who do informative procedures that the HMO deems "unnecessary" (even if they are totally legitimate) can easily go bankrupt. In short, there is no motivation for doctors under HMOs to go the extra mile to really understand the cases they are studying in detail.

    --
    i\hbar\dot{\psi}=\hat{H}\psi
    1. Re:What doctors do these folks go to? by ResidntGeek · · Score: 1

      Doctors aren't researchers. They're doctors, they're supposed to do exactly what you describe. They use the existing knowledge of medicine and apply it to people's illnesses to make them feel better.

      --
      ResidntGeek
    2. Re:What doctors do these folks go to? by MorePower · · Score: 1

      I agree with you that you can't expect "front-line" doctors to try to find the cause of weird, rare, unknown to science type diseases (although it would be nice if they could refer you to researches studying those things). But in my experience they don't delve into anything much at all, they seem to just look at a database somewhere that lists "symptoms x,y, and z -> give them pill w". Maybe (if you're "lucky") the database will say "perform test t to screen for failure of organ r".

      Doctors seem to go through an extensive education which should give them the ability to actually have some insight like "Hmm, your spleen seems to be agitated by something, but the characteristics are not typical for a viral infection. Have you been eating a lot of wild game meat recently?" and figure out what is really going on. If they are just going to do a database lookup, why can't they just make a website somewhere where we can type in our symptoms? It would save us all a lot of time and money, and the doctors could focus on stuff that actually requires some expertise.

    3. Re:What doctors do these folks go to? by xPsi · · Score: 1

      Point well taken. However, cases must be forwarded by doctors to researchers somewhere on the planet (like in the case of TFA). I'm just not sure what criteria they use.

      --
      i\hbar\dot{\psi}=\hat{H}\psi
    4. Re:What doctors do these folks go to? by ResidntGeek · · Score: 1

      Well, we're in a small subset of people that would usually prefer our medical care that way. 99% of a doctor's life is taken by soccer moms with kids who've gotten allergies at the same time every year, bringing them in to see if they're dying. You can bet your ass they don't want to type their symptoms into a database themselves.

      Besides which, few diseases have a 1:1 correlation between a set of symptoms and the disease. It's like the Dilbert lines (paraphrased) "Did you hear about the new flu virus going around? First you feel perfectly healthy, then you die!" "Wait a minute, I feel perfectly healthy!" If people were left to find their own diseases, we'd be overrun with hypochondriacs because I'm sure there are a lot of severe diseases which have mild symptoms, then death.

      I think you might also be trivializing medicine a bit. In a pediatrician's or a podiatrists's office or something like that, I imagine diagnosis is retardedly simple, but I'd be surprised if it were so in an emergency room, trauma center, or the like. There are a lot of diseases in the world, and doctors have to know EVERY common disease and injury the minute they get to work, symptoms, causes, severity, and outlook. If all it took were a WebMD search they wouldn't have to go to school for 8 years.

      --
      ResidntGeek
    5. Re:What doctors do these folks go to? by Anonymous Coward · · Score: 0

      why can't they just make a website somewhere where we can type in our symptoms

      "You have... LEPROSY!"

    6. Re:What doctors do these folks go to? by MorePower · · Score: 1

      I guess you're right on a lot of points, sometimes the doctors do casually mention "looks like a stomach virus" or something, so maybe they do know what's going on. They just often don't seem to communicate it very well to the patient. I think the soccer mom type you mentioned is probably the cause of this. That soccer mom just wants to know "Are they going to die?" and "What drugs do I need to buy to make this go away?" and over time they train the doctors to just give the "executive summary" of the problem, focussed on how to quickly fix it.

      I really wish that wasn't the case though, as it has put me off to doctors entirely. Assuming its a non-emergency situation (in which case I want the doctor to shut up and save me) the main reason I would go to a doctor is for the insight into what's going on and why and how and what factors contribute to worsening or improving the conditions and what are the trade offs involved in my possible treatments.

      It always seems like they just want to throw a pill at you, often without telling you what the pill does, and say "thank you, drive thru". On many occasions I've ended up taking what turned out to be a glorified asprin before I wised up and started asking specifically what it was for (and eventually just stopped going to doctors altogether). I'm not comfortable throwing exotic chemicals into my body, but I'll do it if the benefit/risk ratio is high enough. Easing minor, dull pain is not a very high benefit for that ratio, so I'd like to know if the doc is just going after the symptoms (which I can probably just endure for a few days/weeks) or if that pill is meant to prevent the spread of the disease into my vital organs.

      I really wish the doctors would treat diseases interactively like that, discussing what's going on and why. I mean you wouldn't expect, say, a financial planner to just collect your bank statements, pay stubs, and tax records and then say "ok your need buy this much of Mutual Fund A, a little bit of Fund B, you will retire at age 63 and have income X. Thank you, drive thru." The whole point of paying for a professional like that is to pick their brains in their area of expertise and develop a strategy based on your own goals and value judgements.

    7. Re:What doctors do these folks go to? by Domo-Sun · · Score: 1

      Yeah, and 95% of the time, people get better whatever the doctor says, so they get away with it, looking like an expert. When you don't get better, they just call you a hypochondriac or say you're depressed and prescribe a variety of designer head drugs.

  31. Re:The question is... by MadnessASAP · · Score: 1

    Symptoms last for 10 months and possibly more, I hope for you that its one long rave party because you are going to real unhappy if it's over before then.

    --
    I may agree with what you say, but I will defend to the death your right to face the consequences of saying it.
  32. I Wonder..... by IHC+Navistar · · Score: 1

    I wonder if Ciquatoxin can make bad sex feel good.....

    --
    Knowing Google's lust for data collection, the Soviet Union is still alive and well inside the psyche of Sergey Brin....
  33. Sorry, not happening (Lobbies) by ChromeAeonium · · Score: 1, Interesting

    Sorry, but that's probably not going to happen. The oil lobbies are too powerful, and won't hesitate to to make sure this never sees the market. It's happened before.

    Have you ever heard of Synsepalum dulcificum, aka the Miracle berry? It contains a substance called Miraculin that alters the way humans taste. Basically, sour becomes sweet when you have some of it make contact with your tongue. Sounds like a great low calorie sugar substitute, right? I mean, sugar's not good for you, and this stuff would eliminate the need to put sugar in a lot of products.

    Well, Miraculin was isolated, proven safe, but couldn't go to the market because the sugar lobby gave it the smack down. They knew that it could ravage the sugar industry, so they played strong arm. If this Ciguatoxin is proven safe and usable for keeping warm, and people would only need to heat their homes to safe levels instead of warm and comfortable tempatures, I'd wager that the oil industry would do the same thing and get the FDA to declare this stuff unsafe as well.

    1. Re:Sorry, not happening (Lobbies) by Domo-Sun · · Score: 1

      First of all, I'm not sure people can be cold but have the cold sensation reversed, and still function at temperatures that feel uncomfortable. I think there might be an increase in heart failure or something, because everyone's (warm blooded) body/weight/temperature is different.

      Second of all, another sugar substitute, Stevia, a sweet and calorie free plant, was banned because the sugar lobby (Neutrasweet) pressured the FDA to ban it. It's currently available if labeled ONLY as a supplement.

    2. Re:Sorry, not happening (Lobbies) by Domo-Sun · · Score: 1

      "Miraculin...alters the way humans taste." It makes them taste ethically delicious. Mmm... Brains... Don't you see? The sugar lobby was just protecting us from becoming zombies.

    3. Re:Sorry, not happening (Lobbies) by Hoi+Polloi · · Score: 1

      LSD can make the color blue taste sweet and something sour sound like church bells but the "man" banned that too.

      --
      It is by the juice of the coffee bean that thoughts acquire speed, the teeth acquire stains. The stains become a warning
  34. Re:HOW MANY NIGGERS DOES IT TAKE TO CHANGE A LIGHT by Anonymous Coward · · Score: 0

    the word "nigger" is one of the most universally offensive words in the English language

    Then why do the kids in the subway call each other "my nigger"? Part of racism is a double standard. It is no less racist for the-N-word to be forbidden to white men but acceptable from black men, than the obvious racism in the original troll post. Anyone who gets offended by me saying "nigger" and then goes on to enjoy the same word in their music is pretending at victimhood. That is the largest obstruction to clearing up the remaining real racism left in this country.

  35. phantom teeth symdrom by ILuvRamen · · Score: 0

    If you actually did lose your teeth, does it then cause phantom teeth syndrome? Cuz that would be the opposite I guess.

    --
    Google's Super Secret Search Algorithm: SELECT @search_results FROM internet WHERE @search_results = 'good'
  36. So you're saying ... by timothy · · Score: 1

    ... that this is the one fish poison I'll want to take all year?

    (Think of the Eskimo market!)

    timothy

    (Yes, yes -- "Inuit," among other words.)

    --
    jrnl: http://tinyurl.com/c2l8yr / foes: http://tinyurl.com/ckjno5
  37. You're lucky by Anonymous Coward · · Score: 3, Funny

    "what the hell is my wife taking that makes her cold even when I'm sweating bullets!"

    Don't worry, in a few more years, she'll be feeling hot all the time. And she'll yell at you a lot. For no reason you're aware of.

    But on the plus side, all your hair will fall out, and your children will consider you stupid. Which, all things considered, you are.

    1. Re:You're lucky by Anonymous Coward · · Score: 0

      your children will consider you stupid. Which, all things considered, you are.

      That made me choke on my Guinness. Good show.

  38. Re:The question is... by Anonymous Coward · · Score: 0

    Enjoy staying home and posting on /.

  39. You forgot by markov_chain · · Score: 1

    to call it a cure! ;)

    --
    Tsunami -- You can't bring a good wave down!
  40. Not for me by markov_chain · · Score: 1

    I noticed that I always catch a fish minutes after my buddy arrives!

    --
    Tsunami -- You can't bring a good wave down!
  41. Terrorism? by tcolberg · · Score: 1

    If terrorists poisoned Canadians and Wisconsins with this, would the people be frightened and angry or would be happy that they could break out their shorts in the middle of winter?

  42. Ré:Botété by Anonymous Coward · · Score: 0

    Whén I was in the Séa of Cortés, wé éxpériéncéd that diséasé whén wé até Totuava caught thé day béforé. I think it wasn't cookéd thoroughly, so wé sufféréd from our stupidity. Cook the food, péoplé! Sushi'd bass, or anything éatén partially-cookéd is stupid. Yés, that means Japanésé are stupid too. Don't éat raw Japanésé; gotta cook thém all, gotta cook thém all!

    PS: you shouldn't havé uséd that "é" thing in your post. Now I'll bé using it for the rémaindér of my trolling days on thé océans of Slashdot.

  43. If sex feels bad... by DG · · Score: 1

    ...then you're doing it wrong.

    The solution is technical, not chemical.

    DG

    --
    Want to learn about race cars? Read my Book
    1. Re:If sex feels bad... by delinear · · Score: 2, Funny

      Dude, I think he meant for her...

  44. Answer to Global Warming... by bratwiz · · Score: 1


    So let me get this straight... you're saying that the answer to global warming is this fish poison???

    Does Al Gore know about this???

    (Did he invent the stuff???)

  45. Uh, no.... by jd · · Score: 1

    hey won't dismiss you just like that. They'll first try two or three expensive medicines by the drug company sponsoring them that week, and THEN dismiss you. Well, after also prescribing the antidote (if any) to their earlier prescriptions.

    --
    It's a small world and it smells funny; I'd buy another if it wasn't for the money; Take back what I paid (SoM)
  46. Re:Umm...Psychoactive drugs? by Anonymous Coward · · Score: 0

    Dude, if you stay in your Mom's basement chopping up body parts, you're not a nerd, you're Norman Bates.

  47. Medical applications by Tisha_AH · · Score: 1

    That's an interesting question. There are many chronic pain disorders that still do not have a satisfactory treatment.

    An example;
    Polyneuropathy- (burning sensations, tingling, pain), the primary treatment is a nerve block (no, not a vulcan neck pinch). A long needle shoved into a nerve bundle.

    Who would have thought that cayenne pepper concentrate, applied topically, would have been a good pain management technique?

    Certainly this condition has been known of since Captain Cook but there are plenty of conditions that we only know about in a superficial way. Basic science and research are how we discover new pharmaceuticals and treatment regimens.

    --
    Tisha Hayes
  48. Nope by Anonymous Coward · · Score: 0

    XNOR is like logical equivalence, not like negation

    http://en.wikipedia.org/wiki/XNOR_gate

  49. Big deal... by butterwise · · Score: 1

    temperature reversal, a burning sensation, and an imaginary feeling of loose teeth
    That happens every time I pee.
    --
    If a baby duck is a "duckling," why would anyone want to eat "dumplings?"
  50. Re:HOW MANY NIGGERS DOES IT TAKE TO CHANGE A LIGHT by Amouth · · Score: 0

    Thank You AC - i have never understood why others don't get that - and while i normaly don't mod AC posts if i had had mod points today i would have +1 Under rated - people need to think abou this..

    --
    '...if only "Jumping to a Conclusion" was an event in the Olympics.'
  51. Re:HOW MANY NIGGERS DOES IT TAKE TO CHANGE A LIGHT by Anonymous Coward · · Score: 0

    I second that, sir.

  52. what an asshat! by Taco+Meat · · Score: 0

    Wow, a "christian" and a racist. You're just as bad as the trolls you posted under. Judging from your post history, it's hard to tell if you're a troll or just a moron. It seems you are equal parts of both.

    Censorship? Hardly. You can still read the post. It's just that *educated* people are past your redneck inbred antebellum racist bullshit and thus such twaddle gets modded accordingly. Censorship. Riiiight.

    --
    It's not narcissicism if it's true!
  53. Ecstasy by davidwr · · Score: 1

    Ecstasy was legal for along time after it became a recreational drug.

    --
    Knowledge is how to play a game, intelligence is how to win, wisdom is knowing what game to play.