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Elderly Mice Perk Up With Transfused Blood
Some exciting news, as reported by the Wall Street Journal, might make you glad that human blood is a renewable resource: "Giving old mice blood from young ones makes them smarter and improves such functions as exercise capacity, according to reports from two research teams that point to new ways to study and potentially treat diseases of aging. In one study, researchers at Stanford University and the University of California, San Francisco found that blood transfusions from young mice reversed cognitive effects of aging, improving the old mice's memory and learning ability. The report was published Sunday in the journal Nature Medicine. Two other reports appearing in Science from researchers at Harvard University found that exposing old mice to a protein present at high levels in the blood of young mice and people improved both brain and exercise capability. An earlier report by some of the same researchers linked injections of the protein to reversal of the effects of aging on the heart. ... What isn't known from all this research, said Buck Institute's Dr. [Brian] Kennedy, is whether young blood might also increase the life span of mice and, if so, what such implications for humans might be."
I can see the dystopia: Young people selling blood to old folks to pay the interest on student debt, mortgage debt, credit card debt... the old generation literally sucking the blood of the new generation.
http://online.wsj.com/news/articles/SB10001424052702303417104579541950544978572
I LIKE this idea. Catch the slow and the stupid so that I might drain them of their own precious bodily fluids so that I might prolong my own life.
On a somewhat less silly note I do wonder just how much of an improvement can be had via this. And more importantly how might it be applied to new treatment techniques. Using some of the regenerative techniques maybe we could culture, say, the bone marrow of a baby and use it to constantly produce fresh blood. Maybe every few years go in for a completely 'oil change'.
... that they got from another study: http://www.grg.org/SMelov.htm
but at least these mice weren't genetically engineered to only live a week to begin with so this result may have a (lot) more relevance.
Fortunately despite the worries of the (first!) poster, hopefully we won't descend into a civilization where the old literally becomes a vampiritic parasite on the young. They've already identified, isolated and synthetically produced (the?) protein which causes this effect so we'll be able to get the benefits without bloodletting. Still makes (made?) a great premise for science fiction/vampire movies.
As an aside, I'm impressed by how Harvard, a decade or two ago, seemed to make the decision not to go into (what I thought) was the trendy/hot science of genetic engineering but instead has invested hundreds and hundreds of millions of dollars into becoming the(?) center for stem cell research. Meanwhile, genetic engineering seemed to have been sidetracked by "junk DNA" and epigenetics and in general the overwhelming complexity of the human genome (although the invention of CRISPR is a major major advance). Was it obvious to biologists that this was the right decision? Go Crimson!
maybe vlad the impaler's wife was on to something!
Remember kids, if you're not paying for the service, YOU ARE THE PRODUCT THAT IS BEING SOLD.
I, for one, welcome our new vampire overlords!
The injected 'young' plasma, which improved the ability of the hippocampus, which improved learning and memory. Obviously they are trying to isolate what exactly is different about the blood that is different.
The focus is on the protein GDF11, which seems to cause improvements. The article suggests it will be three years before human testing of GDF11.
"First they came for the slanderers and i said nothing."
Isolate the protiens the young mice have that the old mice don't have. Blood transfusions aren't necessary... Just saline and protien.
Wait ... I can just use my own :(
Maybe they were just given young blood by male researchers and got scared into running faster.
Disclaimer: for some reason, I can't check the linked article, so I have no idea who the authors and lab techs are on the original papers.
We need to progress this technology quick. We need to progress human trials. It is important we know if this method could improve human function as well such as doing endurance sports like cycling.
Isn't this why Mr. Burns has lived to be over 100 years old?
(Reference to a South Park episode where the characters reference The Simpsons as already doing that storyline)
You do realise that the rich and powerful can easily pay the fast and the strong to catch you so that they can drain your precious bodily fluids so that they can prolong their own lives. Still like the idea?
I just saw a Spiderman movie with a similar plot
Table-ized A.I.
Stealing advanced Romanian scientific discovery!!!!!
"The average reporter we talk to is 27 years old......They literally know nothing." - Ben Rhodes
She would recover for about six weeks.
But on the third time- she died of blood poisoning- which is a risk from getting a blood transfusion.
But it was kinda like I got to see her again after she had been gone for a long time, replaced by a sort of dotty, eccentric person. She was suddenly sharp, intelligent and the fuzziness went away.
She was like chocolate when she drank... semi-sweet at first and then increasingly bitter.
Isolate the protiens the young mice have that the old mice don't have. Blood transfusions aren't necessary... Just saline and protien.
The previous studies that had the same result eventually concluded that it was the pluripotent stem cells in the blood which had come out of the marrow as part of normal blood production.
On this basis, a treatment was developed (and insurance approved) using autologous stem cell transplantation; it's a common treatment for some types of cardiac events. There are also transplants involving harvesting of marrow stem cells, and then separating leukotic stem cells from those which are non-leukotic, and then growing and storing them while the patient undergoes radiation or chemotherapy to kill of their remaining marrow (this requires frequent transfusions to keep the blood volume of functional cells up, as the body is no longer replacing them itself at a high enough rate). Subsequent to this, the saved and separated cells are then transplanted back into the long bones (the rest of the interior areas of the smaller bones are allowed to be recolonoized by stem cells that escape the long bones). Since the treaments are autologous, you about conditions like interstitial pneomonitis, or the need for anti-rejection therapy, which is sometimes problematic when using a heterologous cell source.
See also: http://en.wikipedia.org/wiki/A...
As it stands, hundreds of thousands of people in the United States donate blood and plasma everyday, not out of goodness of heart, but for the quick $50 you get. If it turns out that this procedure not only works on humans, but that the effects are substantial, and the FDA actually approved the practice, the value and price of blood would go up and the number of donors would skyrocket. This could cause problems like increasing the cost of a blood transfusion for someone who is bleeding out from a bad accident. It may introduce social problems like a suddenly expanding elderly population, but perhaps they would be better able to take care of themselves and would require less age-disease related medication. Then their is the problem of who pays for it. People who retired with a lot of money may be able to pay what could be a hefty price, but what of people in lower classes? If this extends life, would it not be a right to life issue where anyone past a certain age is guaranteed the procedure? Would Medicare pick up the bill? What about retirement and the employment market? Ideally we will discover that a whole blood transfusion is not necessary but that instead there is just one component of young blood that would need distilled, cloned, grown in a lab and infused in smaller amounts then a full transfusion.
At the end of the day, life extension is one of the major goals of modern medicine, and aging itself is increasingly be viewed as a disease. Whether or not this pans out, eventually something will, and we will then enter into stranger times then we already live. Cheers to the future for better or worse.
Brought to you by Carl's Junior.
Exxcccceellleennntt
Get the orphans here, adopt them, get them hooked on "Twilight" and then drain them. Everybody's happy.
This is old news. They also tried it in reverse and found the young where hurt by getting old people's blood.
Most of the coverage of this story is reporting the "Happy happy joy joy!" aspects (cure heart disease! reverse aging! improving mental agility!), but a few outlets are reporting that there's also a risk for cancer.
They'll just figure out how to mass produce the protein, patent it, give it an inscrutable name like Hemobulex Flummuxterone, a trade name like HemoNu and sell it for eleventy billion dollars a bottle.
Most of Slashdot is Republican and very, very easily offended. You will be modded down.
Stem Cells travel in the blood and must obey Hayflick's Limit.. i.e. we all don't make Telomerase.. so our parts have a "Limited Warranty". When they "Spoil" they either produce Cancer, or Expire.. As Yoda would say "There is no Try.." If you could tamp the immune system down far enough, you could quite literally live a very long and relatively healthy life by Transfusions -- but not for energy, the fat energy cycle would have to continue. So "technically" the X-Files got that "Righter" with Fat Vampires.. but Rejuvenation would be realm of the Blood Vampires. Stem Cell cloning of Islet cells to fight Diabetes Type 2 is also right.. and a little gene therapy might help with P53... of coure some already have a Genotype favorable to CC which means they won the lottery already and frequently live to 125 or slightly more.. but even they would need the Stem Cell transfusions to out run Hayflick's Limit.
This effect was known about as far back as 1969.
Its kind of funny that we are looking at making Nano-machines, robots to infiltrate the blood when we already have the templates or blueprints for the first generation in our blood, even more so since the white blood cell Stem cells have the ability to squeeze into and around organ tissue to infiltrate and fight infections from within. As Stem cells they are the Universal replacement part, and in theory could cause instant tissue regeneration.. and ironically are members of the Immune system. So in programming "terms" Stem cells are a "Class" object with the definition for the perfect nano-machine, and already proven to be tasked and loaded with the exact methods needed to sponsor human life. As "Instances" of the perfect and proven nano-machines we want, their only failing is that they have a limited lifespan dictated by their Telomeres and AutoAtopsis. Our own younger versions could be harvested and frozen for use years and then revived and reintroduced into their donor to Rejuvenate them, or we could take older White Blood cell Stem Cells and introduce Telemerase to re-wind their clocks, and sort the Cancerous from the Non-Cancerous versions and reintroduce those.. but guess which would be cheaper? And the of course the "true Blood Vampires" could just live off other donors White Blood Stem cells.. but with attendant cancer risks and immune problems.. gradually degnerating from all the collateral damage.. ironically like the "Vampires of Lore"
Next Google investment you'll hear about is mice.
https://plus.google.com/+Larry...
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Ozzy uses young bats.
I'll have another Bloody Mary.
Some settling may occur during posting.
It may sound like a good idea but will get you banned from the Tour de Fance.
Ah, so now consuming the blood of virgins won't count as a purely recreational activity...
We do all make Telomerase in some of our stem cells, just not in somatic cells and certain semi-differentiated stem cells. In fact someone knocked out Telomerase in mice and showed they hyperaged and lived only 6 months (rather than 3 years) without it (interestingly they also found you could rescue them by reintroducing telomarase). In short Telomarase seems to be part of the cellular ageing mechanism, rather than the organism level one. Whatever is causing organism level ageing relates to more than just telomeres.
The Immortal, 1969
Just a VamPyric one
It's a trick to get the world's powerful sociopaths to worry about global warming.
Does this work across species? Does this work if you inject young mouse blood into old humans? How about pig blood? As creepy as it sounds, I could imagine an enterprise that harvests animal blood and sells it to humans.
Could you inject old human blood into young people as some sort of punishment? Or to educate them about what it feels like to get older?
The old (Reagan, Thurmond, Helms) way of doing this was to inject pureed brain tissue from aborted fetuses directly into the brain.
If you can get most of the same benefits from staying on the other side of the blood/brain barrier that'll be more sustainable.
Had it right all along.
James Gunn's _The Immortals_ and/or the 1970 TV series _The Immortal_, which specifically deals with an elderly (m/b)illionaire pursuing a man with Really Good gamma globulins in his blood, intending to keep him around as a living blood bank.
Elizabeth Barthory
Humans are natural. Everything we do is natural.
There is only nature. Everything else is fantasy. So if we develop anti-aging and eventually immortality - it will be perfectly natural.
Moral? Practical? Manageable? Sustainable?
Completely different issues.
captcha: restroom [What we do there, also perfectly natural.]
Is there some more information since last year?
http://science.slashdot.org/st...
Move along, no sig to see here.
Bart transfused Mr.Burns.
In "Krazy Kripples", Christopher Reeve comes to town to promote stem cell research. In order to 'cure' his quadriplegia, he is shown sucking the fluids out of fetuses from a medical bio-hazard container. With each fetus he sucks dry, Reeves becomes healthier and more dependent on them for his developing super human strength.
It must have been something you assimilated. . . .
One harmful side-effect in multiple transfusion recipients is iron overload. Some people are more prone to this than others, depending on how good their genetics is at conserving iron. Overdose of iron can lead to liver damage in acute intoxication, liver cancer and increased oxidation phenomena in chronic cases. There are even hypotheses about surplus iron being at the origin of degenerative diseases like alzheimers / parkinsons. So people doing transfusions of young blood as a way to stay young might be exchanging a temporary increase in performance for steeply increasing risks of cancer and degenerative disorders.
...I will be opening a day care center.
On second thought, come on over and play.
Muhaaahaaahaaa!
Have gnu, will travel.
to me, this seems to imply that most of the effects of aging are hormonal. if that was already known, this study should be labeled 'duh'. if that was not already known, well, duh!
http://youtu.be/VRNwqVU70Q8/
The good news is that you've been offered an intern position at a major healthcare provider, providing critical support for elderly patients...
Wonder if we can give some of this young mouse blood to Stuart Little to improve M J Foxe's battle.