Just about every major drug development in the past 15 years has come from the public sector, not the private sector.
Simply not true.
Antibiotics are mostly private sector. You might be implying that drugs that are life preserving don't usually come from the private sectors. There are plenty of good examples of life preserving drugs (antibiotics). There are also plenty of good examples of life-enhancing drugs (omeprezol - Prilosec). Or the combination of the both (silfenildil - Viagra was originally indicated to reduce heart attacks, but it had an interesting side effect).
IT IS NOT CAPTIVE MARKETING!!! Blame foreign governments for the high prices here. They don't allow drug companies to charge for R&D costs.
But there are two sides of the argument here too. Here's an analogy The US may be seen as flying first class. They get from point A to point B but pay a much larger price than those in coach (foreign citizens buying drugs). But if airline companies started charging less for first class and distributing the cost to coach, then fewer people are inclined to pay for coach. There are much fewer people on the plane. The plane never leaves the ground.
Drug companies have 20 years from the filing of patent to have exclusive rights to the drug. After going through NDA and FDA approvals the average drug gets 7 years on the market. Meanwhile, hundreds of millions of dollars are needed to be recovered in 7 years.
If we combine the effects of foreign governments not allowing US based companies to charge for "R&D costs" (they allow a small amount of profit), US citizens usually get a bum deal in terms of name brand drugs. US residents are accustomed to paying high prices. That is why the main R&D center of the largest British pharmaceutical company is located near Philly.
Luckily this summer, the Senate passed the Schumer-McCain bill that helps boost access to generics and boosts competition. The traditionally self-competing and bickering major generic manufacturers also have formed a pharmaceutical association in a similar vein as the major pharma companies.
I am a med student who is concurrently getting an MBA in health administration. The current health care costs are 14% of our GDP (~$1.4 trillion) and drugs are the fastest increasing component of the cost.
Please, if we are all to help force down drug prices, ask your pharmacist for generics
It's exactly the opposite in America. We as consumers and business owners brag about how much we saved. Have you ever talked to somebody who bought a shirt at Banana Republic and asked how much it cost him? He doesn't say, "It cost mye $60" even if he's wealthy. He says he got it for 30% off.
We're a country that likes high prices and high discounts. Many B2B companies (e.g. oil field suppliers) don't even offer "normal" price to any of their customers. Every sale is a certain percent off their list; that percent depends on how important the customer is to the company.
To address the original issue, it's been proven time and time again that people are more likely to pick a higher priced product if quality is one of the main motivating factors. (Even if the lower priced product ends up being of higher quality).
At least that's what they tell us in Business School.
The problem with this is that SKA time (for using it) would be super expensive and super competitive. I don't think many reputed astronomers are going to give up their limited time on the 'scope to search for little green people. They have papers to write.
Since a light year isn't an SI unit, I don't think it matters.
Personally, I find 8 light minutes easier to conceptualize than 1368 micro-light years. We all think of minutes as very small compared to years. I'm pretty sure that all of us, being nerds that we are, have calculated how MANY minutes there are in a year. And most of us know that it takes light just minutes to reach the inner planets. But when I think of micro-light years I have nothing to reference. Can light reach Mercury in a micro-light year? Jupiter?
It's just a matter of taste and custom. But since light-years aren't standardized, I don't see a problem with the norm.
Jeez. I can't wait to enter the corporate warzone. And if 80% of "office toys" (by Dan's examples) are projectile weapons, I guess I should prepare now. They never tell us about this in school. Whatever happened to loving traditional office toys like red Swinglines?
The US sent many missions to the moon. Many. And most of those after Apollo 11 were manned. Someone else could probably tell you how many other people landed on the moon.
I agree that travelling to the moon was essentially a race against another superpower which we opposed. But the US would have to substantiate it in order to convince the USSR (if I told my enemy that I make $1M a year, he wouldn't believe it). But the fact is, Russia eventually acknowledged it in their textbooks (although they dedicate more print to Yuri).
The flag looks like it's blowing in the wind because there's a distinct metal bar on the top of the flag to hold the flag outright. You can tell from any old photograph.
Yes, I know that I misspelled "there." Yes, I know that I didn't use an end-quote. Yes, I know that Francis Drake was an explorer/pirate. Please don't comment on these mistakes. Maybe next time I'll use "preview."
William of Ockham - "One should not increase, beyond what is necessary, the number of entities required to explain anything."
Francis Drake - "My whole life's work, from SETI to the Drake equation to the 1970's Arecibo radio transmission, depends on their being aliens somewhere in the Universe, so I'll pop up every year or so and assert that ET does exist so I won't be a failure.
much like japan, the US is a testing ground. there's a lot of crap and there's a lot of good stuff on the market here. nobody buys the crap, but we pay for the r cost of the crap through higher prices on the good stuff. then the US corporations turn around and sell the good stuff to the rest of the world for cheaper.
prime example: the drug industry. did you know that americans are the ONLY PEOPLE IN THE WORLD that are supporting the high cost of pharmaceuticals? we pay $4/pill for nexium to support r and astrazeneca (who make the drug) turns around and sells it for $1 to europe because the european (and most other) governments refuse to allow US corporations to include r costs when exporting their product (they allow a moderate margin after costs only).
why do you think that the biggest pharmaceutical corporation in britain has it's r department in the US? in fact it's more than 50% located in the states.
so while we may be whiny brats, we deserve some innovations from other countries too.
I've also tried the beta version and they've worked extremely well and the features had been improving with each of the 6 beta version.
To answer your question, Apple and Mediafour have always had an understanding. Mediafour has previously made the successful Macdrive, which let PCs read Mac files. Other than Apple's request for Mediafour to rename their product from XPod to Xplay (Xpod sounded too similar to iPod), Mediafour has gotten the unofficial/implicitly understood ok from Apple.
"In an advisory today, Eeye warned that the flaw in the "MSN Chat OCX control" enables an attacker to "supply and execute code on any machine on which MSN Messenger with the ActiveX is installed."
As a result, even non-active Messenger users, or those who access the service using a third-party product such as Trillian, should upgrade to the new MSN Chat control.
'The attack doesn't happen through the chat client, so as long as you have MSN Messenger installed, if I send you a special URL, I can own you,' said Marc Maiffret, Eeye's 'chief hacking officer.'"
i'm sure marc actually said, "1 c4n 0wN j00," but the washington post author didn't know what the hell he was talking about.
The "complaint" is just that authors want more money from new book purchases.
There's nothing wrong with wanting that. Hell, if I were an author, I'd want people to buy new copies of my book rather than recirculating old copies. If the Authors' Guild help out their constituents by directing more sales to B&N, where presumably they would get more new book sells, then more power to them. If they're affective, then Amazon will learn and then modify their display tactics in order to regain business.
It's a capitalistic society and the Authors' Guild is just playing it.
i did the opposite yesterday in boston. i had time on early friday afternoon so i saw "monsters inc." and then immediately "the one." i believe i was the only one that laughed when i heard the line "there WILL be only one" near the end of the movie as if exchanging "will" for "can" will make it not a highlander ripoff. but, regardless, anyone can tell it's a highlander ripoff by the trailers and previews.
If people were really excited about getting Windows XP (there are quite a few of them), then they would have got their hands on it earlier. eBay had some up for sale. My brother got a copy of XP a little less than a month ago and offered it to me, but I told him to just get the money he could make from an eBay sell (it was about $350 back then).
I think release dates are getting less and less important now in the days of advanced comunication and distribution. Remember those days when people would line up for hundreds of feet Tuesday at midnight for the release of a CD? Those days have been dwindling, and the lines are getting smaller. If one really wants that CD he'll download it before the release date and then take his time getting the CD after it's released. Tower record parties on Newbury Street in Boston are nonexistent anymore. Just 3-4 years ago they were incredible with radio staion vans parked everywhere and hundreds of people croweded around.
How do you teach thinking when there are many different types of intelligent thinking?
I'm just starting med school now and we've had a couple of exams. I'm in class with some of the brightest minds of America. You would think that my class would have similar types of minds, because we all had to go through the same screening process, but we all perform differently on different types of exams.
I'm not so good at brute force memorization. It takes me much longer than my collegues to study for a biochem exam and i only do average on them. Yet I can rock the molecular bio exam with little studying because it's based on applied knowledge.
Thinking is very different for different people. It develops at an early age (thank you parents for pushing me) but takes years to develop. i didn't learn how to think for myself until i got to high school. I felt I was behind my classmates until I learned how to do applied knowledge very well. I suppose when others were memorizing, I was using connecting schematics.
To answer my first question, I would probably go about it through a "well-rounded" education. If I hadn't majored in philosophy as an undergraduate, I'm sure I wouldn't have been good at applied knowledge skills. If I had taken more classes where memorization plays a big role, then maybe I would have been better at that. As of right now, I'm the only one in my class that cannot remember more than 20% of the names of our classmates.
Why is the U.S. such a big believer in precedents? No other country determines case outcomes based on precedent as strongly as the U.S. If we can get over our precedents maybe we wouldn't have to worry so much about the future. Things can be decided on a case-by-case basis.
That way cases like Bowen v. AHA (courts allowed Down's Syndrome patient to die from an easily curable gastric obstruction because the parents asked the doc not to operate *wink, wink*) won't really matter in the future.
There will always be cases that make bad precedents for the future. The AHA had a good lawyer (probably Keker caliber) and they successfully defended themselves. Who's to say which is the "right" precedent to establish in a case. Maybe if we didn't hold on so strongly to precedents...
the purchaser of the first WinXP system attempted to install the OS on his laptop so that he can take full advantage of the features on the road. Subsequently, a big 3D image of Bill Gates' head on a blue background encompassed the screen. Mr. Gates' single index finger then popped up and shook vigorously back and forth.
The purchaser immediately had an MI, not because he hadn't read the EULA, but because anyone would be scared s**tless by Windows' "new and improved" blue screen of death, which will now shut down computers everywhere not because of hefty codework but because Mr. Gates' head doesn't like bad licensing.
I will agree that some/. posters aren't all that perceptive of what they should and should not do. I however am not one of them. Both the numbers were made up on the spot and Bob doesn't exist (you had no way of knowing that though, sorry). But I think a cooler SSN would have been 188-88-8881. It's prime, palindromic, uses only 2 different digits, and you can turn it upside down and it'll still be the same (without the hyphens). I WOULD be jealous of that number.
My social security number is 486-65-4324. I was jealous of my collegue, Bob Andrews, who has 777-66-6667, which is made of only 2 different types of digits AND is PRIME!
Now I know Bob will get a better I.P. address too. Some people... they're just born with everything. Lucky bastards....
It's kind of funny that nobody has commented on the fact that the virtual RPG trade started with UO, not Everquest, and it was before 1997.
But even before UO, there was that obscure trading card game called "Magic" where rich nerds, the same that buy items in Diablo, shelled out big bucks for the Black Lotus.
And before Magic, there were all the kids who collected baseball cards. Some lucky kid got a Mickey Mantle rookie and he sells it to the rich nerd across the street.
Real money for unsubstantial things (electrons or paper card) has been with us for awhile.
The movie's director, Gus Van Sant (CT:Good Will Hunting, not J&SBSB of course), has a funny bit part, and Smith parodies Charlie's Angels, The Fugitive (so specifically he includes a reference to Provasic, the drug that nearly destroyed Richard Kimble's life), Scooby-Doo,Hannibal, and even Star Wars (Carrie Fisher and Mark Hamill appear, the latter in a loopy take-off on the mythic brawl between Darth and Luke
You forgot all the great references that Jay and Silent Bob make to itself in the movie.
Slashdot Mirror
Just about every major drug development in the past 15 years has come from the public sector, not the private sector.
Simply not true.
Antibiotics are mostly private sector. You might be implying that drugs that are life preserving don't usually come from the private sectors. There are plenty of good examples of life preserving drugs (antibiotics). There are also plenty of good examples of life-enhancing drugs (omeprezol - Prilosec). Or the combination of the both (silfenildil - Viagra was originally indicated to reduce heart attacks, but it had an interesting side effect).
IT IS NOT CAPTIVE MARKETING!!! Blame foreign governments for the high prices here. They don't allow drug companies to charge for R&D costs.
But there are two sides of the argument here too. Here's an analogy The US may be seen as flying first class. They get from point A to point B but pay a much larger price than those in coach (foreign citizens buying drugs). But if airline companies started charging less for first class and distributing the cost to coach, then fewer people are inclined to pay for coach. There are much fewer people on the plane. The plane never leaves the ground.
Drug companies have 20 years from the filing of patent to have exclusive rights to the drug. After going through NDA and FDA approvals the average drug gets 7 years on the market. Meanwhile, hundreds of millions of dollars are needed to be recovered in 7 years.
If we combine the effects of foreign governments not allowing US based companies to charge for "R&D costs" (they allow a small amount of profit), US citizens usually get a bum deal in terms of name brand drugs. US residents are accustomed to paying high prices. That is why the main R&D center of the largest British pharmaceutical company is located near Philly.
Luckily this summer, the Senate passed the Schumer-McCain bill that helps boost access to generics and boosts competition. The traditionally self-competing and bickering major generic manufacturers also have formed a pharmaceutical association in a similar vein as the major pharma companies.
I am a med student who is concurrently getting an MBA in health administration. The current health care costs are 14% of our GDP (~$1.4 trillion) and drugs are the fastest increasing component of the cost.
Please, if we are all to help force down drug prices, ask your pharmacist for generics
It's exactly the opposite in America. We as consumers and business owners brag about how much we saved. Have you ever talked to somebody who bought a shirt at Banana Republic and asked how much it cost him? He doesn't say, "It cost mye $60" even if he's wealthy. He says he got it for 30% off.
We're a country that likes high prices and high discounts. Many B2B companies (e.g. oil field suppliers) don't even offer "normal" price to any of their customers. Every sale is a certain percent off their list; that percent depends on how important the customer is to the company.
To address the original issue, it's been proven time and time again that people are more likely to pick a higher priced product if quality is one of the main motivating factors. (Even if the lower priced product ends up being of higher quality).
At least that's what they tell us in Business School.
The problem with this is that SKA time (for using it) would be super expensive and super competitive. I don't think many reputed astronomers are going to give up their limited time on the 'scope to search for little green people. They have papers to write.
Since a light year isn't an SI unit, I don't think it matters.
Personally, I find 8 light minutes easier to conceptualize than 1368 micro-light years. We all think of minutes as very small compared to years. I'm pretty sure that all of us, being nerds that we are, have calculated how MANY minutes there are in a year. And most of us know that it takes light just minutes to reach the inner planets. But when I think of micro-light years I have nothing to reference. Can light reach Mercury in a micro-light year? Jupiter?
It's just a matter of taste and custom. But since light-years aren't standardized, I don't see a problem with the norm.
Jeez. I can't wait to enter the corporate warzone. And if 80% of "office toys" (by Dan's examples) are projectile weapons, I guess I should prepare now. They never tell us about this in school. Whatever happened to loving traditional office toys like red Swinglines?
The US sent many missions to the moon. Many. And most of those after Apollo 11 were manned. Someone else could probably tell you how many other people landed on the moon.
I agree that travelling to the moon was essentially a race against another superpower which we opposed. But the US would have to substantiate it in order to convince the USSR (if I told my enemy that I make $1M a year, he wouldn't believe it). But the fact is, Russia eventually acknowledged it in their textbooks (although they dedicate more print to Yuri).
The flag looks like it's blowing in the wind because there's a distinct metal bar on the top of the flag to hold the flag outright. You can tell from any old photograph.
Yes, I know that I misspelled "there." Yes, I know that I didn't use an end-quote. Yes, I know that Francis Drake was an explorer/pirate. Please don't comment on these mistakes. Maybe next time I'll use "preview."
William of Ockham - "One should not increase, beyond what is necessary, the number of entities required to explain anything."
Francis Drake - "My whole life's work, from SETI to the Drake equation to the 1970's Arecibo radio transmission, depends on their being aliens somewhere in the Universe, so I'll pop up every year or so and assert that ET does exist so I won't be a failure.
much like japan, the US is a testing ground. there's a lot of crap and there's a lot of good stuff on the market here. nobody buys the crap, but we pay for the r cost of the crap through higher prices on the good stuff. then the US corporations turn around and sell the good stuff to the rest of the world for cheaper.
prime example: the drug industry. did you know that americans are the ONLY PEOPLE IN THE WORLD that are supporting the high cost of pharmaceuticals? we pay $4/pill for nexium to support r and astrazeneca (who make the drug) turns around and sells it for $1 to europe because the european (and most other) governments refuse to allow US corporations to include r costs when exporting their product (they allow a moderate margin after costs only).
why do you think that the biggest pharmaceutical corporation in britain has it's r department in the US? in fact it's more than 50% located in the states.
so while we may be whiny brats, we deserve some innovations from other countries too.
I've also tried the beta version and they've worked extremely well and the features had been improving with each of the 6 beta version.
To answer your question, Apple and Mediafour have always had an understanding. Mediafour has previously made the successful Macdrive, which let PCs read Mac files. Other than Apple's request for Mediafour to rename their product from XPod to Xplay (Xpod sounded too similar to iPod), Mediafour has gotten the unofficial/implicitly understood ok from Apple.
"In an advisory today, Eeye warned that the flaw in the "MSN Chat OCX control" enables an attacker to "supply and execute code on any machine on which MSN Messenger with the ActiveX is installed."
As a result, even non-active Messenger users, or those who access the service using a third-party product such as Trillian, should upgrade to the new MSN Chat control.
'The attack doesn't happen through the chat client, so as long as you have MSN Messenger installed, if I send you a special URL, I can own you,' said Marc Maiffret, Eeye's 'chief hacking officer.'"
i'm sure marc actually said, "1 c4n 0wN j00," but the washington post author didn't know what the hell he was talking about.
The "complaint" is just that authors want more money from new book purchases.
There's nothing wrong with wanting that. Hell, if I were an author, I'd want people to buy new copies of my book rather than recirculating old copies. If the Authors' Guild help out their constituents by directing more sales to B&N, where presumably they would get more new book sells, then more power to them. If they're affective, then Amazon will learn and then modify their display tactics in order to regain business.
It's a capitalistic society and the Authors' Guild is just playing it.
when can i get in on the action?
From his resume:
Began college study at age 12, completed first MS degree by age 16.
i did the opposite yesterday in boston. i had time on early friday afternoon so i saw "monsters inc." and then immediately "the one." i believe i was the only one that laughed when i heard the line "there WILL be only one" near the end of the movie as if exchanging "will" for "can" will make it not a highlander ripoff. but, regardless, anyone can tell it's a highlander ripoff by the trailers and previews.
If people were really excited about getting Windows XP (there are quite a few of them), then they would have got their hands on it earlier. eBay had some up for sale. My brother got a copy of XP a little less than a month ago and offered it to me, but I told him to just get the money he could make from an eBay sell (it was about $350 back then).
I think release dates are getting less and less important now in the days of advanced comunication and distribution. Remember those days when people would line up for hundreds of feet Tuesday at midnight for the release of a CD? Those days have been dwindling, and the lines are getting smaller. If one really wants that CD he'll download it before the release date and then take his time getting the CD after it's released. Tower record parties on Newbury Street in Boston are nonexistent anymore. Just 3-4 years ago they were incredible with radio staion vans parked everywhere and hundreds of people croweded around.
first post for jon may calling jon katz
How do you teach thinking when there are many different types of intelligent thinking?
I'm just starting med school now and we've had a couple of exams. I'm in class with some of the brightest minds of America. You would think that my class would have similar types of minds, because we all had to go through the same screening process, but we all perform differently on different types of exams.
I'm not so good at brute force memorization. It takes me much longer than my collegues to study for a biochem exam and i only do average on them. Yet I can rock the molecular bio exam with little studying because it's based on applied knowledge.
Thinking is very different for different people. It develops at an early age (thank you parents for pushing me) but takes years to develop. i didn't learn how to think for myself until i got to high school. I felt I was behind my classmates until I learned how to do applied knowledge very well. I suppose when others were memorizing, I was using connecting schematics.
To answer my first question, I would probably go about it through a "well-rounded" education. If I hadn't majored in philosophy as an undergraduate, I'm sure I wouldn't have been good at applied knowledge skills. If I had taken more classes where memorization plays a big role, then maybe I would have been better at that. As of right now, I'm the only one in my class that cannot remember more than 20% of the names of our classmates.
Why is the U.S. such a big believer in precedents? No other country determines case outcomes based on precedent as strongly as the U.S. If we can get over our precedents maybe we wouldn't have to worry so much about the future. Things can be decided on a case-by-case basis.
That way cases like Bowen v. AHA (courts allowed Down's Syndrome patient to die from an easily curable gastric obstruction because the parents asked the doc not to operate *wink, wink*) won't really matter in the future.
There will always be cases that make bad precedents for the future. The AHA had a good lawyer (probably Keker caliber) and they successfully defended themselves. Who's to say which is the "right" precedent to establish in a case. Maybe if we didn't hold on so strongly to precedents...
the purchaser of the first WinXP system attempted to install the OS on his laptop so that he can take full advantage of the features on the road. Subsequently, a big 3D image of Bill Gates' head on a blue background encompassed the screen. Mr. Gates' single index finger then popped up and shook vigorously back and forth.
The purchaser immediately had an MI, not because he hadn't read the EULA, but because anyone would be scared s**tless by Windows' "new and improved" blue screen of death, which will now shut down computers everywhere not because of hefty codework but because Mr. Gates' head doesn't like bad licensing.
I will agree that some /. posters aren't all that perceptive of what they should and should not do. I however am not one of them. Both the numbers were made up on the spot and Bob doesn't exist (you had no way of knowing that though, sorry). But I think a cooler SSN would have been 188-88-8881. It's prime, palindromic, uses only 2 different digits, and you can turn it upside down and it'll still be the same (without the hyphens). I WOULD be jealous of that number.
I know exactly how that feels...
My social security number is 486-65-4324. I was jealous of my collegue, Bob Andrews, who has 777-66-6667, which is made of only 2 different types of digits AND is PRIME!
Now I know Bob will get a better I.P. address too. Some people... they're just born with everything. Lucky bastards....
It's kind of funny that nobody has commented on the fact that the virtual RPG trade started with UO, not Everquest, and it was before 1997.
But even before UO, there was that obscure trading card game called "Magic" where rich nerds, the same that buy items in Diablo, shelled out big bucks for the Black Lotus.
And before Magic, there were all the kids who collected baseball cards. Some lucky kid got a Mickey Mantle rookie and he sells it to the rich nerd across the street.
Real money for unsubstantial things (electrons or paper card) has been with us for awhile.
The movie's director, Gus Van Sant (CT:Good Will Hunting, not J&SBSB of course), has a funny bit part, and Smith parodies Charlie's Angels, The Fugitive (so specifically he includes a reference to Provasic, the drug that nearly destroyed Richard Kimble's life), Scooby-Doo,Hannibal, and even Star Wars (Carrie Fisher and Mark Hamill appear, the latter in a loopy take-off on the mythic brawl between Darth and Luke
You forgot all the great references that Jay and Silent Bob make to itself in the movie.
As I would say, the movie was meta-funny.