Isn't baseball the premier game for nerds? Look at all of the obsessive statistical analysis done (e.g. SABR)...
The whole issue of who is juicing and who is not now puts into question all of the records and stats assocaited with Baseball. Does McGuire's HR record still count or not? I'm sure that there are plenty of Sabermaticians who will debate that for quite some time...
The reason that the adenoviral therapy killed Jesse Gelsinger is that they a) used a form of the virus that causes an immune response b) miscalculated the dose that they gave him and c) injected it directly into his hetatic portal vein (right into his liver).
This is a big problem with adenovectors - even in the best cases, patients will get at least a little sick from them. There are next generation forms that are less toxic, but these are still in development.
The real advance here was that they were able to combine the minimal "cell killing" aspect of HIV with another virus, Sindbis, to create a gene therapy that is relatively benign. They then modified that to target this to specifically kill a certain type of tumor. Previous attempts at HIV-based gene therapies proved to be too toxic.
Of course this was all in mice, which don't get AIDS from HIV. Whether it would in people is another story.
The idea that the extracellular matrix might control neuron plasticity is not all that far fetched - there are many studies showing that cell function is controlled by the extracellular environment.
Another aspect to consider is that diseases such as Alzheimers are associated with the accumulation of misfolded proteins (plaques) in the extracellular environment. Although the prevailing idea is that these plaques might be toxic or the residue of dead cells, it's not impossible to think that plaques could also "de-program" neurons by altering the normal extracellular environment.
I have one and I use it all the time. Obviously you can't use it to navigate menus, but you can still dial regular phone numbers and the thing is built like a tank. Plus, it has a nice line amplifer, so the receiver sounds better than most phones...
Next, these robot probes would create huge biotechnology laboratories. The DNA sequences of the probes' creators would have been carefully recorded, and the robots would have been designed to inject this information into incubators, which would then clone the entire species. An advanced civilisation may also code the personalities and memories of its inhabitants and inject this into the clones, enabling the entire race to be reincarnated.
I'm all for speculation, but this seems beyond far-fetched. Seems like the author is trying to impose 21st century style thinking to solve a "problem" that may or may not happen millions of years from now.
If the original author really wanted to be speculative, how about the notion that living beings that can escape the universe might have evolved beyond requiring DNA or might be energy-based rather than a matter-based life form...
Here is yet another example of releasing findings by press release. This is amazingly irresponsible, since it looks like the study involved irradiating cells in a dish. Not applicable to human exposure at all...
Here are my favorite quotes:
Because of the lab set-up, the researchers said the study did not prove any health risks.
and
"We don't want to create a panic, but it is good to take precautions," he said, adding that additional research could take another four or five years.
In other words, I need more funding to support my sketchy research that may or may not be applicable to human exposure - sheesh.
If Firefox does enter the "comfort zone" (perhaps not likely) then some other browser will take over. The key was to get the average user to realize that you don't have to use IE with Windows...
Re:hold on there
on
HIV Vaccine
·
· Score: 5, Informative
They are talking about dendritic cells which are a component of the immune system - not neural tissue.
The idea of broadcasting my ID continuously is distrubing, but it seems reasonable that passports could be issued with a sleeve that would block tranmission of the RFID signal.
Suppose that you had 20,000 different kinds of Lego blocks and the ability to make an unlimited amount of each type. How many different things could you build?
Even discounting for protein modifications and assuming one gene = one protein, 20,000 genes is plenty to build a human.
This site is updated daily to give the predicted electoral vote counts - more informative than the overall popular vote totals. He also covers the Senate races and issues related to polling ingeneral. The site does have a somewhat pro-Kerry viewpoint, but it seems like the poll data is non-partisan...
As such, the journal has to be contacted to get reprints, not the author(s).
Although this might (or might not) be the letter of the law - in practice even the most restrictive journals (New England Journal, Science Nature, etc.) provide reprints to authors of papers that they are free to redistribute as they see fit.
Slashdot Mirror
True, which is why I didn't bring up Leap Seconds.
Fun calculation ... although you could use 365.25 days/year if you wanted to take leap years into account.
Anyone out there actually eat spam on a regular basis?
An internist and a surgeon come to an elevator. The door is closing, so the internist inserts his hand.
"Why'd you do that?" asks the surgeon.
"Well," the internist answers, "you use the least important part of your body to stop an elevator door."
They go into another wing, and approach another elevator. It's closing. So the surgeon sticks his head in.
There's been a recent boom in labeling ongoing research projects with the buzz word "nanotechnology" to make them seem "sexier" ...
The whole issue of who is juicing and who is not now puts into question all of the records and stats assocaited with Baseball. Does McGuire's HR record still count or not? I'm sure that there are plenty of Sabermaticians who will debate that for quite some time ...
Yeah, that was a typo ... sorry about that.
The reason that the adenoviral therapy killed Jesse Gelsinger is that they a) used a form of the virus that causes an immune response b) miscalculated the dose that they gave him and c) injected it directly into his hetatic portal vein (right into his liver).
This is a big problem with adenovectors - even in the best cases, patients will get at least a little sick from them. There are next generation forms that are less toxic, but these are still in development.
The real advance here was that they were able to combine the minimal "cell killing" aspect of HIV with another virus, Sindbis, to create a gene therapy that is relatively benign. They then modified that to target this to specifically kill a certain type of tumor. Previous attempts at HIV-based gene therapies proved to be too toxic.
Of course this was all in mice, which don't get AIDS from HIV. Whether it would in people is another story.
Tastes fishy to me - I guess that I've always had Plain Sushi instead of Premium Quality Photo Sushi ...
Another aspect to consider is that diseases such as Alzheimers are associated with the accumulation of misfolded proteins (plaques) in the extracellular environment. Although the prevailing idea is that these plaques might be toxic or the residue of dead cells, it's not impossible to think that plaques could also "de-program" neurons by altering the normal extracellular environment.
I have one and I use it all the time. Obviously you can't use it to navigate menus, but you can still dial regular phone numbers and the thing is built like a tank. Plus, it has a nice line amplifer, so the receiver sounds better than most phones ...
Next, these robot probes would create huge biotechnology laboratories. The DNA sequences of the probes' creators would have been carefully recorded, and the robots would have been designed to inject this information into incubators, which would then clone the entire species. An advanced civilisation may also code the personalities and memories of its inhabitants and inject this into the clones, enabling the entire race to be reincarnated.
I'm all for speculation, but this seems beyond far-fetched. Seems like the author is trying to impose 21st century style thinking to solve a "problem" that may or may not happen millions of years from now.
If the original author really wanted to be speculative, how about the notion that living beings that can escape the universe might have evolved beyond requiring DNA or might be energy-based rather than a matter-based life form ...
No monolith, but this one has what looks like an airstrip at the far left ...
If I'm having an overpriced cup of coffee at Starbucks and paying for WiFi, they damn well better let me plug in ...
Here is yet another example of releasing findings by press release. This is amazingly irresponsible, since it looks like the study involved irradiating cells in a dish. Not applicable to human exposure at all ...
Here are my favorite quotes:
Because of the lab set-up, the researchers said the study did not prove any health risks.
and
"We don't want to create a panic, but it is good to take precautions," he said, adding that additional research could take another four or five years.
In other words, I need more funding to support my sketchy research that may or may not be applicable to human exposure - sheesh.
If Firefox does enter the "comfort zone" (perhaps not likely) then some other browser will take over. The key was to get the average user to realize that you don't have to use IE with Windows ...
They are talking about dendritic cells which are a component of the immune system - not neural tissue.
More like a regular book / magazine, I guess, but it seemed a little weird. I guess vertical scrolling is just too ingrained ...
Steve Potter, the former mentor of the UF researcher has a pretty thorough description of it. http://www.neuro.gatech.edu/groups/potter/animat.h tml
The idea of broadcasting my ID continuously is distrubing, but it seems reasonable that passports could be issued with a sleeve that would block tranmission of the RFID signal.
Even discounting for protein modifications and assuming one gene = one protein, 20,000 genes is plenty to build a human.
Valves = tubes in Brit-speak ...
This site is updated daily to give the predicted electoral vote counts - more informative than the overall popular vote totals. He also covers the Senate races and issues related to polling ingeneral. The site does have a somewhat pro-Kerry viewpoint, but it seems like the poll data is non-partisan ...
Don't forget NeXT? It might have worked with a "mature" internet ...
Although this might (or might not) be the letter of the law - in practice even the most restrictive journals (New England Journal, Science Nature, etc.) provide reprints to authors of papers that they are free to redistribute as they see fit.