Ad 2: No I do not. Progeria is caused by mutations in lamin A/C. Telomerase, as you say, keeps telomeres at length. So, if you have defective telomerase, your telomeres shorten.
Other processes (please name them) all are likely to work via the first three. In the end, it all boils down to genomic maintenance. This includes reprogramming of chromatin and the like, if that's what you mean by other processes.
Not a nut, just not very well informed. See, one of the fun things happening now in molecular biology is that we are starting to see the contours of the agin g process. And it looks like it is actually three processes in one:
1. There's a sensor in your cells that measures the amount of oxidative damage done. Beyond a certain limit it kicks in the senescence program, and BAM! your cells go into G2 meaning a slow coast to death (can't go into much detail on this one)
2. Stem cell maintenance. You need telomerase for that, an enzyme composed of RNA and protein. It keeps the length of the ends of your chromosomes more or less constant. People without functional telomerase (a disease called dyskeratosis congenita) die at a young age of anemia, leukemia and other disorders associated with aging. They also have bowel problems and their skin looks like it's 80 years old when they're 30
3. Genome integrity. A whole bunch of enzymes is busy keeping your chromosomes from breaking, effecting all kinds of different repairs needed for all sorts of damage that a genome (an organism's DNA) can suffer. Various diseases result from a lack of one of these enzymes and they all mimick an aspect of ageing (Werner's, Bloom's, Xeroderma Pigmentosum, Fanconi anemia etc etc).
So, preventing ageing will not be the result of tackling oxidation or whatever on its own (which is what all the supplements are doing). IF we are ever going to be able to offer any kind of athanatic treatment (term borrowed from Dan Simson) it is going to be a complex one.
Delightful post! The/. crowd that is interested in taxonomy might also be interested to know that some diseases have rather funny names as well. For instance, there is an annoying itching skin disease called "lichen planus", meaning flat moss. It can also be lichen ruber - red moss. A particular congenital disorder is known as CATCH22. Moebius is also the name of a syndrome. Or, perhaps better known, "syphilis" which means fond of pigs (because people felt that affected patients had behaved like pigs?). For more fun medical terms, see for instance here and, completely off topic but funny nonetheless, here for mistakes made with medical terms.
True. However,for remote control there are third-party solutions available from Belkin and others. If you want to use windows media player, there is a nice remote available from Keyspan ( here). For the TV screen, I wouldn't know. Sounds like you might have wanted Windows XP Media Center, if that weren't a too expensive and platform bound solution.
OK, I am probably the nth person writing to say this, so mod me redundant... But, why this complicated solution? For a couple hundred bucks you by an iMac (candy colored one) and put in a big hard disk. Connect decent speakers. Use iTunes. And there you are, instant juke box. Why this complicated solution? I mean, you get mega geek points, but as far as simplicity for elderly people is concerned, your way is not the way to go IMHO. My kids have the iMac + speakers solution and it works wonderfully. They use Audion with a nice skin for kids snd have required only very limited explanation of how it works.
Not at all. Do you honestly believe that the labels are doing this for your (the customer's) good, to enable you to choose the mediaplayer and format you want? Then you're truly naive. Labels are greedy, greedy and greedy, in that order. The only reason that they are banding together on DRM now is that they are afraid that they will lose control (=revenue) over their digital music offerings to Apple, Microsoft or some other digital content provider. Which would serve them right.
The virgin galactic (which translates to Virgin Milky...) site gushes about the spiritual experience for rich tourists ("executive jets"..."dine with astronauts" yadda yadda) but the true opportunity for the foreseeable future will be IMHO in high speed intercontinental flight for those for whom it is really important. Let space tourism pave the way (like the rich did with the automobile) but let's not forget the ultimate goal. Then I can finally go to a conference in Australia without haveing to reserve two days for getting there!
to all who think that DNA sequencing is going to solve the debate:
1. The DNA had to be extracted from bone. This is difficult, the DNA may be fragmented leading to incomplete or dubious sequences.
2. One way to look at population genetics is to look at mitochondrial DNA, which is transmitted maternally. All assumptions on dating changes in that DNA depend on assumptions about mutation rates which are increasingly turning out to be incorrect.
3. Another way to do it is to look at repetitive sequences in DNA. Here, the amount of change between population groups is used as a timer for divergence. Turns out that repetitive DNA attracts mutations, again screwing up timing estimates.
Add to this a nice mixture of ethnic pride, scientific pride and plain old human thickheadedness and we have ourselves a nice new long debate that isn't going to be solved anytime soon. Still, I like the idea. It's provocative and might actually help (in the long run) to rid the debate of who was there first of unconstructive emotions.
For note taking (and book reading, by the way), we humans like something that falls within the realm of experiences that we evolved to deal with. Scratching with a pen on paper, which generates tactile stimuli and visual ones, seems to fit the bill nicely since we all are apt to do this (Post-It notes, anyone?). So, until we have e-paper that can be maltreated just like r-paper (real paper) with an e-pen that can be handled like an r-pen, all digital note taking technologies are going to fail. It should be clear by now that it is almost impossible to mould people into a particular technology. If you don't believe me, then why is you monitor full of post-it notes?
That's really gracious. I actually don't think that the interviewee is retarded, I think that the interviewer is a pompous ass who thinks of himself as a real intellectual artiste.
I am so sorry, Michael-san, but I think that this interview is a load of crap. It may be about anime but as an interview and background about some decidedly good anime it just won't do. For instance: "This is a promiscuous story of a lonesome "ghost" of a man, who nevertheless seeks to retain humanity. Innocence... That's what life is." about Ghost in the shell:2. What the hell is a promiscuous story? One that screws around? What do you mean "that's what life is"? Life is not about being artificial and trying to retain humanity. This kind of pseudo-intellectualism really irritates me. It tells me nothing about the movie, its background or why it should be interesting. And this: "What are your goals for the future?
My goal is to establish CG in a unique 'Production I.G' style, and introduce it to the world. Because of this, I like to learn about everything earnestly. I want to live and work with pride, respect people, treasure the nature and cherish my country." He definitely seems like a nice guy, respecting Nature and all that, but what does he want to do with CG? What's so unique about the style? Does he also want to learn about quantum mechanics earnestly then? Et cetera, et cetera. Vapid.
Enough ranting, but please, let's have some more interesting stuff on slashdot, shall we?
Since when are Hollywood actors "real"? I personally have never seen someone who even remotely resembles Angelina Jolie (or has any of her -uhm- physical attributes) - I keep thinking that she must be the result of some heavy duty CGI herself:)
how Firefox is being plugged. It's pretty obvious IMHO from the site that Firefox has the wind in its sails so to speak, as it's offered for download (geared to your OS, nice) with a biggo font. If you want Mozilla, you have some more clicks to go. Does that mean that Mozilla will be superseded at some point by Firefox??
It's interesting in this regard to think of the announcement some weeks ago of iTunes coming to Motorola cellphones. Then you have several record companies offering tunes and whatnot through a single channel. Talking about set prices... I wonder what the antitrust laws would have to say about that.
The easy explanation as I was given to understand is that the photons propagate in spacetime, ie the wave that they are does. Spacetime is curved by gravity, hence the photons/waves curve with them. According to General relativity, they cannot have mass since they propagate at light speed. Any object with mass obtains infinite mass upon attaining lightspeed, which is impossible. Hence a photon has no mass. Of course, solar sails work so photons can exert pressure which might lead one to suppose they have mass. In sense they do, as energy and matter are equivalent. In the case of a solar sail, it is impulse that is being transferred. It depends on how you measure the presence of the photon. By the way, note that Duif does not cast doubt upon Einstein's theories per se. Rather, he invokes the presence of dark matter (although no one has ever demonstrated its presence unequivocally).
You're probably right. I'm an Apple user myself and am not looking to bash Apple or something. But for a computer company that compares itself to BMW it is not acceptable that something like that should be possible at all. If you buy a BMW you don't want a model that has been known to be losing wheels in preproduction runs on the test circuit.
Just goes to show that there is nothing new under the sun. It has happened before. Rather annoying and shameful for Apple that is should happen again in one of the most popular powerbooks.
Dear Phroggy
Please refrain from using words like "retarded" in the near future unless you are specifically looking to start a flame war. I was looking for a discussion, not waiting for someone I don't know to start being rude. Thank you.
That said, the first thing that will happen when this gets through is that sites in the UK will be blocked only to be replaced by sites overseas that cannot be taken down (which is what i was saying in the first place). The spamming business is an international one.
In theory it sounds nice. However, there are several problems here. First, the offending web site may be hosted by an ISP that doesn't give a damn. It may be overseas. It may be in Russia, or North Korea for that matter. If it is in a non-british jurisdiction all they can do is block access to it. There is no way to take it down. The link may be a referral. As others have already noted, the linked address may be that of someone the spammer doesn't like, resulting in the shutdown or blocking of an innocent web site. With so many potential problems, I doubt whether this initiative has a chance of succeeding.
an interesting rock dubbed 'Longhorn'. There! What more proof do you need that Bill Gates is a Martian, intending to end the War of the Worlds? Longhorn is a secret weapon, waiting to be released from Mars. Launch is being postponed time and again by Microsoft because the launch window from Mars to Earth will come up later than anticipated.
All about RINEX: http://www.ngs.noaa.gov/CORS/instructions2/
Cycle slipping is explained here:
http://www.gmat.unsw.edu.au/snap/gps/gps_survey/ch ap7/735.htm
Slashdot Mirror
Ad 2: No I do not. Progeria is caused by mutations in lamin A/C. Telomerase, as you say, keeps telomeres at length. So, if you have defective telomerase, your telomeres shorten. Other processes (please name them) all are likely to work via the first three. In the end, it all boils down to genomic maintenance. This includes reprogramming of chromatin and the like, if that's what you mean by other processes.
Good for him, but it doesn't mean that the supplements work.
He may eat 250 pills a day and feel like 40 but he sure does look like he's 56 years old!
Not a nut, just not very well informed. See, one of the fun things happening now in molecular biology is that we are starting to see the contours of the agin g process. And it looks like it is actually three processes in one:
1. There's a sensor in your cells that measures the amount of oxidative damage done. Beyond a certain limit it kicks in the senescence program, and BAM! your cells go into G2 meaning a slow coast to death (can't go into much detail on this one)
2. Stem cell maintenance. You need telomerase for that, an enzyme composed of RNA and protein. It keeps the length of the ends of your chromosomes more or less constant. People without functional telomerase (a disease called dyskeratosis congenita) die at a young age of anemia, leukemia and other disorders associated with aging. They also have bowel problems and their skin looks like it's 80 years old when they're 30
3. Genome integrity. A whole bunch of enzymes is busy keeping your chromosomes from breaking, effecting all kinds of different repairs needed for all sorts of damage that a genome (an organism's DNA) can suffer. Various diseases result from a lack of one of these enzymes and they all mimick an aspect of ageing (Werner's, Bloom's, Xeroderma Pigmentosum, Fanconi anemia etc etc).
So, preventing ageing will not be the result of tackling oxidation or whatever on its own (which is what all the supplements are doing). IF we are ever going to be able to offer any kind of athanatic treatment (term borrowed from Dan Simson) it is going to be a complex one.
Delightful post! The /. crowd that is interested in taxonomy might also be interested to know that some diseases have rather funny names as well. For instance, there is an annoying itching skin disease called "lichen planus", meaning flat moss. It can also be lichen ruber - red moss. A particular congenital disorder is known as CATCH22. Moebius is also the name of a syndrome. Or, perhaps better known, "syphilis" which means fond of pigs (because people felt that affected patients had behaved like pigs?). For more fun medical terms, see for instance here and, completely off topic but funny nonetheless, here for mistakes made with medical terms.
True. However,for remote control there are third-party solutions available from Belkin and others. If you want to use windows media player, there is a nice remote available from Keyspan ( here). For the TV screen, I wouldn't know. Sounds like you might have wanted Windows XP Media Center, if that weren't a too expensive and platform bound solution.
OK, I am probably the nth person writing to say this, so mod me redundant... But, why this complicated solution? For a couple hundred bucks you by an iMac (candy colored one) and put in a big hard disk. Connect decent speakers. Use iTunes. And there you are, instant juke box. Why this complicated solution? I mean, you get mega geek points, but as far as simplicity for elderly people is concerned, your way is not the way to go IMHO. My kids have the iMac + speakers solution and it works wonderfully. They use Audion with a nice skin for kids snd have required only very limited explanation of how it works.
Not at all. Do you honestly believe that the labels are doing this for your (the customer's) good, to enable you to choose the mediaplayer and format you want? Then you're truly naive. Labels are greedy, greedy and greedy, in that order. The only reason that they are banding together on DRM now is that they are afraid that they will lose control (=revenue) over their digital music offerings to Apple, Microsoft or some other digital content provider. Which would serve them right.
The virgin galactic (which translates to Virgin Milky...) site gushes about the spiritual experience for rich tourists ("executive jets"..."dine with astronauts" yadda yadda) but the true opportunity for the foreseeable future will be IMHO in high speed intercontinental flight for those for whom it is really important. Let space tourism pave the way (like the rich did with the automobile) but let's not forget the ultimate goal. Then I can finally go to a conference in Australia without haveing to reserve two days for getting there!
to all who think that DNA sequencing is going to solve the debate:
1. The DNA had to be extracted from bone. This is difficult, the DNA may be fragmented leading to incomplete or dubious sequences.
2. One way to look at population genetics is to look at mitochondrial DNA, which is transmitted maternally. All assumptions on dating changes in that DNA depend on assumptions about mutation rates which are increasingly turning out to be incorrect.
3. Another way to do it is to look at repetitive sequences in DNA. Here, the amount of change between population groups is used as a timer for divergence. Turns out that repetitive DNA attracts mutations, again screwing up timing estimates.
Add to this a nice mixture of ethnic pride, scientific pride and plain old human thickheadedness and we have ourselves a nice new long debate that isn't going to be solved anytime soon. Still, I like the idea. It's provocative and might actually help (in the long run) to rid the debate of who was there first of unconstructive emotions.
For note taking (and book reading, by the way), we humans like something that falls within the realm of experiences that we evolved to deal with. Scratching with a pen on paper, which generates tactile stimuli and visual ones, seems to fit the bill nicely since we all are apt to do this (Post-It notes, anyone?). So, until we have e-paper that can be maltreated just like r-paper (real paper) with an e-pen that can be handled like an r-pen, all digital note taking technologies are going to fail. It should be clear by now that it is almost impossible to mould people into a particular technology. If you don't believe me, then why is you monitor full of post-it notes?
That's really gracious. I actually don't think that the interviewee is retarded, I think that the interviewer is a pompous ass who thinks of himself as a real intellectual artiste.
I am so sorry, Michael-san, but I think that this interview is a load of crap. It may be about anime but as an interview and background about some decidedly good anime it just won't do. For instance: "This is a promiscuous story of a lonesome "ghost" of a man, who nevertheless seeks to retain humanity. Innocence... That's what life is." about Ghost in the shell:2. What the hell is a promiscuous story? One that screws around? What do you mean "that's what life is"? Life is not about being artificial and trying to retain humanity. This kind of pseudo-intellectualism really irritates me. It tells me nothing about the movie, its background or why it should be interesting. And this: "What are your goals for the future? My goal is to establish CG in a unique 'Production I.G' style, and introduce it to the world. Because of this, I like to learn about everything earnestly. I want to live and work with pride, respect people, treasure the nature and cherish my country." He definitely seems like a nice guy, respecting Nature and all that, but what does he want to do with CG? What's so unique about the style? Does he also want to learn about quantum mechanics earnestly then? Et cetera, et cetera. Vapid. Enough ranting, but please, let's have some more interesting stuff on slashdot, shall we?
Since when are Hollywood actors "real"? I personally have never seen someone who even remotely resembles Angelina Jolie (or has any of her -uhm- physical attributes) - I keep thinking that she must be the result of some heavy duty CGI herself :)
how Firefox is being plugged. It's pretty obvious IMHO from the site that Firefox has the wind in its sails so to speak, as it's offered for download (geared to your OS, nice) with a biggo font. If you want Mozilla, you have some more clicks to go. Does that mean that Mozilla will be superseded at some point by Firefox??
It's interesting in this regard to think of the announcement some weeks ago of iTunes coming to Motorola cellphones. Then you have several record companies offering tunes and whatnot through a single channel. Talking about set prices... I wonder what the antitrust laws would have to say about that.
The easy explanation as I was given to understand is that the photons propagate in spacetime, ie the wave that they are does. Spacetime is curved by gravity, hence the photons/waves curve with them. According to General relativity, they cannot have mass since they propagate at light speed. Any object with mass obtains infinite mass upon attaining lightspeed, which is impossible. Hence a photon has no mass. Of course, solar sails work so photons can exert pressure which might lead one to suppose they have mass. In sense they do, as energy and matter are equivalent. In the case of a solar sail, it is impulse that is being transferred. It depends on how you measure the presence of the photon. By the way, note that Duif does not cast doubt upon Einstein's theories per se. Rather, he invokes the presence of dark matter (although no one has ever demonstrated its presence unequivocally).
I wasn't aware of that one. Well, it sure illustrates the point, no?
You're probably right. I'm an Apple user myself and am not looking to bash Apple or something. But for a computer company that compares itself to BMW it is not acceptable that something like that should be possible at all. If you buy a BMW you don't want a model that has been known to be losing wheels in preproduction runs on the test circuit.
Just goes to show that there is nothing new under the sun. It has happened before. Rather annoying and shameful for Apple that is should happen again in one of the most popular powerbooks.
Dear Phroggy Please refrain from using words like "retarded" in the near future unless you are specifically looking to start a flame war. I was looking for a discussion, not waiting for someone I don't know to start being rude. Thank you. That said, the first thing that will happen when this gets through is that sites in the UK will be blocked only to be replaced by sites overseas that cannot be taken down (which is what i was saying in the first place). The spamming business is an international one.
In theory it sounds nice. However, there are several problems here. First, the offending web site may be hosted by an ISP that doesn't give a damn. It may be overseas. It may be in Russia, or North Korea for that matter. If it is in a non-british jurisdiction all they can do is block access to it. There is no way to take it down. The link may be a referral. As others have already noted, the linked address may be that of someone the spammer doesn't like, resulting in the shutdown or blocking of an innocent web site. With so many potential problems, I doubt whether this initiative has a chance of succeeding.
an interesting rock dubbed 'Longhorn'. There! What more proof do you need that Bill Gates is a Martian, intending to end the War of the Worlds? Longhorn is a secret weapon, waiting to be released from Mars. Launch is being postponed time and again by Microsoft because the launch window from Mars to Earth will come up later than anticipated.
Oh, and ARL:UT is here: http://www.arlut.utexas.edu/ It's Texas university's applied research lab. Use the google, dude :)
All about RINEX: http://www.ngs.noaa.gov/CORS/instructions2/ Cycle slipping is explained here: http://www.gmat.unsw.edu.au/snap/gps/gps_survey/ch ap7/735.htm