More importantly, are 90% of pharma projects unsuccessful?
Way more than 90% fail. But most fail early, before any clinical trials, and don't cost much. Of those that make it to clinical trials, 80-90% fail, depending on how you measure it. But clinical trials are run in phases, so a cancellation after "phase 1" means phases 2 and 3 are never run.
Are 90% of construction projects complete failures? Do 90% of car factories produce no cars? Do 90% of software projects... ok, I will give you this one.
you can't even fathom someone doing research without corporate sponsorship.
I can indeed fathom someone doing a bit of front-end R&D without corporate funding. What I cannot fathom is someone paying tens or hundreds of millions for a clinical trial.
It's robbed you of imagination.
Sorry, I guess I was distracted by paying too much attention to reality.
When you buy a drug, you aren't paying for the production of pills, but rather the R&D. If the dose is cut to one quarter, the cost of the R&D is spread across far fewer pills, so of course the price needs to go up to recoup the development cost.
No. This is completely wrong. "Expert systems" consist of structured and nested "if this do that" tables hand crafted by programmers querying human subject matter experts. Artificial neural networks can accept unstructured data, and find the patterns and correlations on their own. They are completely opposite approaches.
The revolution in trading is happening because of ANNs, not "expert systems".
Academics don't seem to know much either. From TFS: "we're good at judging people and detecting if someone is telling the truth"
Actually, this is something that humans are notoriously bad at. Deep neural networks already exceed human ability to recognize liars, by detecting microexpressions correlated with lying.
In order to have access to the GPP program, its partners must have its "Gaming Brand Aligned Exclusively With GeForce."
Using incentives or threat of coercion to gain exclusivity is considered an anti-competitive practice. In America, it is usually only prosecuted against companies with "market dominance". Nvidia has about a 75% market share.
we have been told that if a company does not participate in GPP, those companies feel as if NVIDIA would hold back allocation of GPUs from their inventories.
If that threat was made in writing, or in front of multiple witnesses, then they should report it to the FTC.
The world record holder for underwater breath-holding is German. I guess they have these spleens too. Who knew?
He did it by breathing pure oxygen for 20 minutes before his attempt.
The longest known breath-hold without supplemental O2 is about 11 minutes. That was someone passively holding their breath. Someone actively consuming oxygen by swimming deep would have less time. So the 13 minutes claimed in TFA is likely BS.
Maybe after a few thousands years of living in space in the future, our species evolves the mutations necessary to combat the ill effects of micro gravity and radiation.
I don't think so. Genetic engineering is making rapid progress. Future changes to humanity will be by design, not through random mutations.
Where would they go, the US is the most right wing capitalist country in the world
Singapore is a low-tax authoritarian country which spends little on social programs, spends robustly on their military, executes drug dealers, and they even spank petty criminals.
So far it is all just talk, no action. So don't get your hopes up. But Trump deserves credit for agreeing to meet, and getting the dialog going. Donald and Jong Un may hit it off, since they have very similar personalities. If the meeting in Pyongyang goes well, maybe Mr Kim can come to the White House for a BBQ later this year.
it would literally be impossible to collect taxes every year without that knowledge.
Taxes have nothing to do with citizenship. Resident aliens pay the same taxes as citizens, even for income earned abroad.
especially considering the majority of them are war vets.
Plenty of "war vets" are not citizens. You do not have to be a US citizen to enlist in the military. The highest rate of American military service is not from any US state. It is from the territory of American Samoa. Unlike Puerto Rico, the US Virgin Islands, and Guam, birth in American Samoa does not confer citizenship.
You'd think the government would know who was a citizen making that irrelevant
The government does not know who is a citizen. There is no centralized "list of citizens". Most births (but not all) are recorded by county governments, but until recently those births were not reported to state or federal levels.
I live in California. My "proof of citizenship" is a piece of paper in the bottom drawer of a filing cabinet in a county courthouse 2500 miles away, where I was born.
The Cambridge Analytica leak was the result of technical incompetence, and poor code review, not bad policy at the level an auditor would see. It is not reasonable to expect a financial auditor to discover bad code.
They're also putting some of the poorest people in the world out of work with automation with this robot.
No they aren't. Most iPhones are made in Shenzhen, which is one of the most prosperous cities in China, and one of the most rapidly growing cities in the world. The unemployment rate in Shenzhen is under 3%, and almost every factory is hiring. The average annual factory income in Shenzhen is about 24,000 RMB which is about $8000 USD-PPP, which may not sound like much to an American, but is a solid middle income by world standards, and wages in Shenzhen are growing by about 10% per year.
The "poorest people in the world" are in landlocked regions of central Africa, not the coastal cities of China.
they only look at temperature. Why were there not any chemical samples taken? pollutant studies?
Pollutants are measured in areas where they are a concern, such as where mine tailings flow into the sea. But the GBR is 2300 km (1400 miles) long, and it is implausible that chemical waste or effluent could have so much effect across such a vast area.
ph level measurement?
Rising CO2 causes ocean ph to drop. This is happening worldwide. It is unlikely that falling ph (rising acidity) is the root problem, because acidity is rising everywhere and reefs are surviving and sometimes even expanding in places like Papahanaumokuakea in the Northwestern Hawaiian Islands, or the Sea of Japan, where temperatures are relatively cool.
Slashdot Mirror
A felony called food tampering?
Let them try it.
How are you even going to know? Spit doesn't have a distinctive flavor.
Tipping is stupid, but that is not the fault of some waitress barely getting by.
So the cashless restaurants are going to have lower prices
Restaurants are in a very competitive business, with a high failure rate. So cost savings are very likely to be reflected in prices.
not charge like 12 bucks for a mixed drink?
More likely they will cut food prices instead. Drinks are less price sensitive. Especially after the first few rounds.
More importantly, are 90% of pharma projects unsuccessful?
Way more than 90% fail. But most fail early, before any clinical trials, and don't cost much. Of those that make it to clinical trials, 80-90% fail, depending on how you measure it. But clinical trials are run in phases, so a cancellation after "phase 1" means phases 2 and 3 are never run.
Citations:
The high price of failed clinical trials
Why too many clinical trials fail
A new look at clinical success rates
Also true in other industries.
Are 90% of construction projects complete failures? ... ok, I will give you this one.
Do 90% of car factories produce no cars?
Do 90% of software projects
Every successful drug has to support the R&D for the 90% that are unsuccessful.
1. /cynical So basically profiting off people's suffering is OK. Got it.
Farmers profit from people's hunger.
2. ./sarcasm Because money is the ONLY motivation to find a cure.
Money is not the only motivation, but it is the most effective motivation.
Money needs to be REMOVED from Big Pharma.
What do you intend to use as a replacement.
you can't even fathom someone doing research without corporate sponsorship.
I can indeed fathom someone doing a bit of front-end R&D without corporate funding. What I cannot fathom is someone paying tens or hundreds of millions for a clinical trial.
It's robbed you of imagination.
Sorry, I guess I was distracted by paying too much attention to reality.
Perhaps you could also tell us what proportion of the 'development costs' are in fact, profits.
Without profits, there is no incentive to do any R&D. Pharmaceutical companies are not charities.
Look at it this way: The dose was cut to a quarter, but the cost was only tripled. So the cost per "cure" actually went down by 25%.
Please, won't someone think of the corporations?
When you buy a drug, you aren't paying for the production of pills, but rather the R&D. If the dose is cut to one quarter, the cost of the R&D is spread across far fewer pills, so of course the price needs to go up to recoup the development cost.
its not AI, its still good expert systems.
No. This is completely wrong. "Expert systems" consist of structured and nested "if this do that" tables hand crafted by programmers querying human subject matter experts. Artificial neural networks can accept unstructured data, and find the patterns and correlations on their own. They are completely opposite approaches.
The revolution in trading is happening because of ANNs, not "expert systems".
Academics don't seem to know much either. From TFS: "we're good at judging people and detecting if someone is telling the truth"
Actually, this is something that humans are notoriously bad at. Deep neural networks already exceed human ability to recognize liars, by detecting microexpressions correlated with lying.
In order to have access to the GPP program, its partners must have its "Gaming Brand Aligned Exclusively With GeForce."
Using incentives or threat of coercion to gain exclusivity is considered an anti-competitive practice. In America, it is usually only prosecuted against companies with "market dominance". Nvidia has about a 75% market share.
we have been told that if a company does not participate in GPP, those companies feel as if NVIDIA would hold back allocation of GPUs from their inventories.
If that threat was made in writing, or in front of multiple witnesses, then they should report it to the FTC.
The world record holder for underwater breath-holding is German. I guess they have these spleens too. Who knew?
He did it by breathing pure oxygen for 20 minutes before his attempt.
The longest known breath-hold without supplemental O2 is about 11 minutes. That was someone passively holding their breath. Someone actively consuming oxygen by swimming deep would have less time. So the 13 minutes claimed in TFA is likely BS.
Maybe after a few thousands years of living in space in the future, our species evolves the mutations necessary to combat the ill effects of micro gravity and radiation.
I don't think so. Genetic engineering is making rapid progress. Future changes to humanity will be by design, not through random mutations.
Where would they go, the US is the most right wing capitalist country in the world
Singapore is a low-tax authoritarian country which spends little on social programs, spends robustly on their military, executes drug dealers, and they even spank petty criminals.
So far it is all just talk, no action. So don't get your hopes up. But Trump deserves credit for agreeing to meet, and getting the dialog going. Donald and Jong Un may hit it off, since they have very similar personalities. If the meeting in Pyongyang goes well, maybe Mr Kim can come to the White House for a BBQ later this year.
it would literally be impossible to collect taxes every year without that knowledge.
Taxes have nothing to do with citizenship. Resident aliens pay the same taxes as citizens, even for income earned abroad.
especially considering the majority of them are war vets.
Plenty of "war vets" are not citizens. You do not have to be a US citizen to enlist in the military. The highest rate of American military service is not from any US state. It is from the territory of American Samoa. Unlike Puerto Rico, the US Virgin Islands, and Guam, birth in American Samoa does not confer citizenship.
Buy why suspend them? Why not just ask them to re-click?
Are you too afraid to say you hate Elon Musk?
I thought he was talking about Peter Thiel.
'But 'rigged' gives a false impression that there was cheating or tampering involved, which there wasn't.
Except that the DNC gave Hillary the debate questions ahead of time.
You'd think the government would know who was a citizen making that irrelevant
The government does not know who is a citizen. There is no centralized "list of citizens". Most births (but not all) are recorded by county governments, but until recently those births were not reported to state or federal levels.
I live in California. My "proof of citizenship" is a piece of paper in the bottom drawer of a filing cabinet in a county courthouse 2500 miles away, where I was born.
The Cambridge Analytica leak was the result of technical incompetence, and poor code review, not bad policy at the level an auditor would see. It is not reasonable to expect a financial auditor to discover bad code.
They're also putting some of the poorest people in the world out of work with automation with this robot.
No they aren't. Most iPhones are made in Shenzhen, which is one of the most prosperous cities in China, and one of the most rapidly growing cities in the world. The unemployment rate in Shenzhen is under 3%, and almost every factory is hiring. The average annual factory income in Shenzhen is about 24,000 RMB which is about $8000 USD-PPP, which may not sound like much to an American, but is a solid middle income by world standards, and wages in Shenzhen are growing by about 10% per year.
The "poorest people in the world" are in landlocked regions of central Africa, not the coastal cities of China.
The Pentium 4 architecture was fucking horrible, and had the albatross of Rambus around it's neck.
Intel also had most of their best people working on Itanium, and only the B-team working on x86.
Once the Athlon iceberg had sunk the "Itanic", Intel put the A-team back to work on x86.
they only look at temperature. Why were there not any chemical samples taken? pollutant studies?
Pollutants are measured in areas where they are a concern, such as where mine tailings flow into the sea. But the GBR is 2300 km (1400 miles) long, and it is implausible that chemical waste or effluent could have so much effect across such a vast area.
ph level measurement?
Rising CO2 causes ocean ph to drop. This is happening worldwide. It is unlikely that falling ph (rising acidity) is the root problem, because acidity is rising everywhere and reefs are surviving and sometimes even expanding in places like Papahanaumokuakea in the Northwestern Hawaiian Islands, or the Sea of Japan, where temperatures are relatively cool.