Unproven therapies usually start out by treating patients with no other good options. Without good data, there is no reason to believe the new therapy is better than the standard of care - that's the whole point of late stage trials.
As doctors and the FDA and insurance companies and patients get more convinced that a therapy is useful, there will be a push to use it at an earlier line of therapy, and the company will run trials in earlier stage patients. Eventually, this could be used as a first line treatment if it proves better than the other options, but it's not statistically convincing yet, so it would be considered unethical to withhold the standard of care in favor of the vaccine.
Combinations of treatments (standard of care + vaccine vs. standard of care alone) are difficult because they are expensive (the vaccine manufacturer would have to pay for all drug for all enrolled patients) and the combination could potentially have increased toxicity.
Early stage (Phase I) trials usually don't have control groups because the goal is to test for toxicity of the therapy. Later stage (Phase II, III) look to compare efficacy against the "standard of care." In this study, no one was admitted to the study but did not receive the therapy - that will happen in the next study.
Phase I trials are traditionally done in health volunteers, but these days, cancer trials are frequently performed in late stage cancer patients because they are desperate and have no other (Western medical) options. These patients had exceedingly little chance of spontaneous recovery, so you can assume the "control" group would have close to 0% survival.
The fact that they got such a huge response is amazing and highly promising.
MIT claimed all of 18.x.x.x early on and just held onto them. When I was there in 2007, I believe they let my frat have full control of all of 18.236.x.x, no subnets required, for 40 guys.
Try running services.msc in Start Menu > Run. That lists all the services that are running and when they start up, whether automatically (at boot) or manually (when needed). I disabled GoogleUpdater, along with other updaters (Java, ITunes, RealPlayer, etc) and things useless to me like Remote Access and Secondary User Log-On.
It seems to me that Universal et al see "downloading music for free" as the entire problem. They somehow don't understand that the biggest reason to download music for free is to put it on your mp3 player. They may have provided free music downloads, but DRM'd music is useless, and won't solve the problem.
Joey: All right, Rach. The big question is, "does he like you?" All right? Because if he doesn't like you, this is all a moo point.
Rachel: Huh. A moo point?
Joey: Yeah, it's like a cow's opinion. It just doesn't matter. It's moo.
Disclaimer: I only know this because my girlfriend quoted it to me, and I googled it for the full text.
Each dorm is assigned all of a second-level IP: 18.XXX.*.*, that's 65536 IP addresses per dorm. At about 300 students per dorm, that's more than 200 static IPs per student...just in case. My fraternity is assigned 512 IPs for 45 guys.
If nothing else, it has skewed my opinion on how quickly we're running out of IPv4 addresses.
I've also heard that MIT rents some of their IPs to Portugal. (This was also the subject of a supposed hack that some MIT student took out an entire country's internet service for a little while.) Does anyone know if either half of this is true?
Has any parent ever told their kid that they used to rebel, and they approved and thought it was cool? Would this make their kid conform, or would the teen's head explode?
Has any parent ever told their kit that they used to rebel, and they thought it was cool that their kids were now doing it? Would that make their kids conform?
That's how you get people to pass legislation that isn't popular - you attach rider bills to attract more votes. Some people would always vote for the "tacked on" part even if the bulk of the bill wasn't popular, while othersacceptefer the main part and simply accept the unrelated parts. I know it doesn't make sense, but if each individual idea brought before Congress was voted on its own merits, not nerely as much would make it into law.
...OK, so that barely makes any sense at all, but that's still how it is.
I'm surprised that no one has mentioned MIT's Open Courseware program (ocw.mit.edu). The goal is to have every class available online, and many have taped lectures for free, for anyone to see, not just students. I had a horrible differential equations professor, so I watched the OCW lectures from the previous term. It sure beat walking to class in the cold.
One book may be more portable than one laptop, but one laptop can store all of your books. You get one delivery and then download the rest of your materials for the rest of your education. I'd rather carry a laptop than a different textbook for math, english, history, science, etc, and I'd certainly rather spend $100 once than $85/book.
Slashdot Mirror
Short answer: Yes, in theory.
Unproven therapies usually start out by treating patients with no other good options. Without good data, there is no reason to believe the new therapy is better than the standard of care - that's the whole point of late stage trials.
As doctors and the FDA and insurance companies and patients get more convinced that a therapy is useful, there will be a push to use it at an earlier line of therapy, and the company will run trials in earlier stage patients. Eventually, this could be used as a first line treatment if it proves better than the other options, but it's not statistically convincing yet, so it would be considered unethical to withhold the standard of care in favor of the vaccine.
Combinations of treatments (standard of care + vaccine vs. standard of care alone) are difficult because they are expensive (the vaccine manufacturer would have to pay for all drug for all enrolled patients) and the combination could potentially have increased toxicity.
Early stage (Phase I) trials usually don't have control groups because the goal is to test for toxicity of the therapy. Later stage (Phase II, III) look to compare efficacy against the "standard of care." In this study, no one was admitted to the study but did not receive the therapy - that will happen in the next study.
Phase I trials are traditionally done in health volunteers, but these days, cancer trials are frequently performed in late stage cancer patients because they are desperate and have no other (Western medical) options. These patients had exceedingly little chance of spontaneous recovery, so you can assume the "control" group would have close to 0% survival.
The fact that they got such a huge response is amazing and highly promising.
MIT claimed all of 18.x.x.x early on and just held onto them. When I was there in 2007, I believe they let my frat have full control of all of 18.236.x.x, no subnets required, for 40 guys.
For those interested, Wikipedia has an amusing list of original A level IP assignments: https://en.wikipedia.org/wiki/...
99% Invisible should be heard by everyone. The host Roman Mars is interesting, interested, and always positive. He makes me feel informed and happy.
Try running services.msc in Start Menu > Run. That lists all the services that are running and when they start up, whether automatically (at boot) or manually (when needed). I disabled GoogleUpdater, along with other updaters (Java, ITunes, RealPlayer, etc) and things useless to me like Remote Access and Secondary User Log-On.
It seems to me that Universal et al see "downloading music for free" as the entire problem. They somehow don't understand that the biggest reason to download music for free is to put it on your mp3 player. They may have provided free music downloads, but DRM'd music is useless, and won't solve the problem.
How does -50 compare to the evil points from supporting censorship in China?
Shouldn't this be from the HandsOffMyCamelCase department?
Joey: All right, Rach. The big question is, "does he like you?" All right? Because if he doesn't like you, this is all a moo point.
Rachel: Huh. A moo point?
Joey: Yeah, it's like a cow's opinion. It just doesn't matter. It's moo.
Disclaimer: I only know this because my girlfriend quoted it to me, and I googled it for the full text.
Each dorm is assigned all of a second-level IP: 18.XXX.*.*, that's 65536 IP addresses per dorm. At about 300 students per dorm, that's more than 200 static IPs per student...just in case. My fraternity is assigned 512 IPs for 45 guys.
If nothing else, it has skewed my opinion on how quickly we're running out of IPv4 addresses.
I've also heard that MIT rents some of their IPs to Portugal. (This was also the subject of a supposed hack that some MIT student took out an entire country's internet service for a little while.) Does anyone know if either half of this is true?
Yahoo Agrees:
Yahoo and Internet Explorer 7: 9,170,000 results
Google and Firefox 2: 26,500,000 results
And you'll need to send money to me, Chief Bello Osagie of Nigeria. I only need enough money to burn it to a CD and I'll ship it to you!
I don't need a back door because my password is "password" for everything.
Oops...now to change all my passwords to "qwerty"...
We'll say, if you're not satisfied with 6, will send you the 7th line free!
There's definitely something about Perl...
Yes, it's fake. bbspot creates satires like theOnion. Their catch phrase is taken from This Is Spinal Tap: their top ten lists "go to eleven".
Has any parent ever told their kid that they used to rebel, and they approved and thought it was cool? Would this make their kid conform, or would the teen's head explode?
Has any parent ever told their kit that they used to rebel, and they thought it was cool that their kids were now doing it? Would that make their kids conform?
Does a radioactive cat have 18 half-lives?
pro : progress :: con : _______
Who would think that the SATs could teach you to question authority?
I'm surprised that no one has mentioned MIT's Open Courseware program (ocw.mit.edu). The goal is to have every class available online, and many have taped lectures for free, for anyone to see, not just students. I had a horrible differential equations professor, so I watched the OCW lectures from the previous term. It sure beat walking to class in the cold.
for...our...overloards
Then why ever shut it down cleanly?
One book may be more portable than one laptop, but one laptop can store all of your books. You get one delivery and then download the rest of your materials for the rest of your education. I'd rather carry a laptop than a different textbook for math, english, history, science, etc, and I'd certainly rather spend $100 once than $85/book.
"Make it last forever, friendship never ends." -Spice Girls
And by "friendship" they were clearly predicting something like YouTube. Maybe they were much smarter than we gave them credit?