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Purchase Your Personal Gene Map

dstone writes "Craig Venter, Time Magazine's Person of the Year in 2000 has a new hobby: collecting rich people's DNA. Millionaires are lining up to buy their personal gene maps for the cool price of USD$621,500. The process takes a week and you get some insight into your genetic mutations that may correlate with illnesses, cancers, Alzeimer's, etc. Venter is a high profile character in the genetic sequencing scene and the Human Genome Project. More info on him may be found here(1) , here(2), and here(3) . If you had the pocket change, would you give this man your business?"

79 of 266 comments (clear)

  1. Anybody want to venture a guess by Noose+For+A+Neck · · Score: 3, Funny

    ...as to how long it is until someone patents my genes?

    --

    Software piracy is victimless theft.

    1. Re:Anybody want to venture a guess by micromoog · · Score: 5, Funny

      I wouldn't worry if I were you.

    2. Re:Anybody want to venture a guess by Suicide · · Score: 2, Funny

      I already have. There will be a per child charge, for using my patented material to create a derivative work. Charge will be based on whether or not you'd like to buy the rights to said derivative work outright (allowing your children to have charge free children), or simply borrow it for the single copy (they will have to pay for the patented material received from you passed down to their derivative work, although at a lesser rate).

    3. Re:Anybody want to venture a guess by deprecated · · Score: 2, Funny

      Your jeans are more likely to be pantsed.

    4. Re:Anybody want to venture a guess by packeteer · · Score: 2

      A better question to ask is when they will FINISH pattenting our genes. Quite a few already have been but not all yet.

      --
      unzip; strip; touch; finger; mount; fsck; more; yes; unmount; sleep
  2. Like PT Barnum said by rimcrazy · · Score: 4, Funny

    A sucker is born every minute....

    --
    "TV, a medium as it is neither rare nor well done." Ernie Kovacs
    1. Re:Like PT Barnum said by powerlinekid · · Score: 2

      Actually David Hannum said that about PT Barnum. It all had to do with the "stone giant" that was found. The best part is when they wouldn't sell it to Barnum (or lease it), Barnum made a copy of it and said that his was the original. The link is found here, its actually a pretty humorous read.

      --

      can't sleep slashdot will eat me
    2. Re:Like PT Barnum said by bytesmythe · · Score: 2

      Soon it'll be "A sucker is CLONED every minute."

      --
      bytesmythe
      Hypocrisy is the resin that holds the plywood of society together.
      -- Scott Meyer
    3. Re:Like PT Barnum said by packeteer · · Score: 2

      I dont think they are suckers. When you are that rich its worth 10x times that ammount to keep yourself healthy. Personally if i could pay that much i would if it would even give me a small cahnce of not getting as sick.

      --
      unzip; strip; touch; finger; mount; fsck; more; yes; unmount; sleep
  3. Why so expensive? by Pupp3tM · · Score: 2, Insightful

    I'm sure it's not that easy to map someone's genes, but hundreds of thousands of dollars? They'd better tell me what kind of cancer I'll get, and when, for that much.

    --
    "Time is an illusion.
    Lunchtime doubly so."
    -Douglas Adams

    David Borowitz
    1. Re:Why so expensive? by Rich0 · · Score: 5, Informative
      I haven't been staying current in the field, but sequencing 4 billion bases of DNA is a LOT! Those costs are not really outrageous when you break them down.

      A typical sequencing reaction is good for about 600 bases (well, that actually is a high-end number - but I think Celera has figured things out well enough to make that regularly). Figure you have to sequence at least 12 billion bases since you have to have some overlap on all the fragments in order to assemble them into a singe genome - 3x overcoverage is a very generous estimage. So 12E9 / 600 = 2E7 reactions. Assume you can do one in two hours (which is probably a bit fast) - that means time for 84 reactions in series in one week (not counting the time it takes to assemble it all - corellating all those sequences takes a LOT of CPU). So - 2E7/84 = 238,095 reactions running in parallel at all times. A $100k sequencer can do about 64 at once.

      I am a biochemist - but I've been out of the field for about three years. So those are ballpark estimates based on where things were going back then. As I see it - they would need to commit $372M in capital to get an earnings of $650k per week - a 9% return on capital, and I didn't even figure in the cost of the reagents and all the robotics it takes to prep the samples, let alone the janitor that sweeps the floors at night. Now, if there has been a 10-100x increase in sequencing throughput in the last year or two I could believe that this is feasible, but it seems a bit far-fetched. Definitely a Craig Ventner idea...

      Then again, that people are even talking about this is very amazing. Keep in mind that only a few years ago they were expecting that the Human Genome still would be undone today - they've been working on it since the '80s. Craig came in and said he'd beat the NIH to the punch by a few years - they changed their methods to come in at a close tie. Now we're talking about being able to do the whole thing in a week. A few years ago the first bacteria was sequenced at less than 1 million bases - and that was BIG news - it took years of work if I recall correctly. At the peak of the Human Genome race Celera was doing one of those each day and then some - mostly because of an ENORMOUS investment of capital as well as a few technology advances.

      This makes me wonder if they will make the customers sign a release to giving Ventner access to statistical data within their genome. One question the completed Human Genome did not answer is how genes vary from person to person - and the only way to answer that question is to sequence lots of genomes. If Ventner can get others to pay for the work and then patent the results that would certainly be a good business move.

    2. Re:Why so expensive? by Animats · · Score: 2
      I'm amazed that they can do it in a week, in a facility which they say cost about US $40 million to build. That's a lot of chemistry.

      On the other hand, correlating the sequences shouldn't be too bad computationally, now that there's an overall map to fit them to. Building the initial map from pieces was a harder job.

      Having full sequences of a number of individuals for comparison is going to be very interesting. Now there's something to compare.

    3. Re:Why so expensive? by Gerry+Gleason · · Score: 2, Insightful
      This makes me wonder if they will make the customers sign a release to giving Ventner access to statistical data within their genome. One question the completed Human Genome did not answer is how genes vary from person to person - and the only way to answer that question is to sequence lots of genomes. If Ventner can get others to pay for the work and then patent the results that would certainly be a good business move.

      Well, yes, this gets to the heart of the matter. Now that they have sequenced the whole thing for at least one human, the real interesting question is how it varies, and then of course how those variations relate to physical traits, diseases, resistence to disease, and so on. I'm sure they want access to the whole thing, not just the statistics. Once you have enough of them, you can start to map variations.

      One thing that I'm a little unclear on from the reports. Are they actually sequencing the whole thing, or just the sections that are parts of genes (i.e. code for proteins). I always understood it to be the former, including all the vast areas that do not code for anything (that they know of). I've always been curious to know if these areas code for other things.

      It's not such a stretch to immagine that these areas contain what we engineers would call "out of band" data that could relate to developmental sequencing or even generational memory (ok, maybe that's a stretch, but possible).

      Just by having the entire sequences of a large number of individuals would make some explorations of this data possible just as pure data. If you find out of band areas that are near identical in all people, that would be a strong indication that it codes for something important.

    4. Re:Why so expensive? by Rich0 · · Score: 2, Interesting
      This is a fascinating topic in itself - what does the DNA which doesn't code for protein do? The majority of your DNA doesn't actually code for protein.

      I am not sure what this new service is going to sequence - the articles suggest it is the whole shebang, but it could just be the expressed portion. If you start with mRNA instead of DNA when making up the clones that are sequenced, you end up just sequencing the coding portion of the genome - which is a LOT less work (again, by far most of your DNA does not code for protein). The actual Human Genome Project and the Celera effort sequenced the whole thing.

      We already know that some sequences of DNA are regulatory in nature - they are sequences that proteins bind to to increase to decrease the rate of gene expression. There are also sequences the DNA replication machinery bind to when copying the DNA. There are highly repetitve sequences which have more topological purposes - such as telomores and centromeres. (The method used to copy DNA cannot copy the very end of a strand, so your chromosomes have regions at the end called telomeres which are repetitive so that nothing "important" is ever near the end of a strand. Centromeres are the region at the center of a chromosome where two halves of an X-shaped replicated chromosome meet).

      I'm personally curious as to how all this "junk" DNA fits into DNA topology. Your DNA isn't just a big long line - it looks more like a tangled phone cord. The most tightly tanged portions are inaccessible by the machinery of the cell that expresses DNA - so it is essentially shut off. I wouldn't be surprised if the sequence coposition of DNA on a large scale influences the overall topology of a chromosome. Bottom line is that we are nowhere close to solving some of the most interesting questions of genetics.

      I wonder when the day will come that you can compile source into a genome just like you compile into machine language today. Imagine having a glibbacteria.so to reference which does all your organism housekeeping functions. You would just write some code to make an organism do something useful, make a statically-linked executable, and then input it into a as-yet-hypothetical large DNA synthesizer. Insert into cell and you have a new organism...

  4. Neat by whereiswaldo · · Score: 3, Interesting

    That's neat. If you charge for a service, people line up for it.
    If the government mandated that you had to let them figure out your genome, people would scream.

    Are these millionaires naive enough to think that a copy of their data will not be kept somewhere?

    1. Re:Neat by ealar+dlanvuli · · Score: 2

      On slashdot, everything is a slipery slope

      (joke!! - sorta)

      --
      I live in a giant bucket.
    2. Re:Neat by bmetzler · · Score: 5, Interesting
      Are these millionaires naive enough to think that a copy of their data will not be kept somewhere?

      What difference does it make whether their data is kept somewhere or not? More to the point, wouldn't they want a copy of their dns on file somewhere?

      Imagine if I had a medical emergency. I'm going to die. Someone needs to make a life or death decision fast. It could save me or kill me. What to do, what to do, what to do? But if I had my DNA on file somewhere, just look it up, and the decision is made.

      I think that it should be mandatory for everyone to have their DNA on file. Imagine the benefit it would provide for not only medical emergencies, but even criminal investigations, and other things.

      -Brent
    3. Re:Neat by NASAKnight · · Score: 2
      Someone needs to make a life or death decision fast.

      Oh, and I'm sure that this information would be readily available to anyone that could save your life, and that they would be able to procure the information in time. If the decision is needed so fast, I'm doubtful anyone could get through all the red tape in time. And as for doctors ... they already have a chart of your medical history, what good is your DNA genome going to be?

      I think that it should be mandatory for everyone to have their DNA on file. Imagine the benefit it would provide

      Imagine the privacy it would violate. Countless examples of misuse of data have already been provided. Let's not give the government any more information than we have to, ok?

      --
      Fault loves the past, worry loves the future, but content enjoys the present.
    4. Re:Neat by evilviper · · Score: 2

      Let's try something:

      What if the police could enter your home, and search through your house at any time, for any reason...
      Imagine the benefit it would provide for not only medical emergencies, but even criminal investigations, and other things.

      Just as in your example, it would trample all over our freedoms, and provide practically no medical benefit. How is your DNA going to help a doctor determine that you were just bitten by a diamond back rattlesnake? How would your DNA help a doctor determine that you've been malnourished?

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      Slashdot gets worse every day... Pipedot: News for nerds, without the corporate slant
    5. Re:Neat by glwtta · · Score: 2
      But if I had my DNA on file somewhere, just look it up, and the decision is made.

      Look up what?? "Ah yes - AGACTGAC, at bp 180,023,982 on chromosome one, this one's a goner I'm afraid."

      The medical industry is nowhere near being able to meaningfuly apply individual sequencing data. Especially in any sort of "life or death decision, fast" situation.

      I get the odd feeling that most people here have a very vague idea of how these things work in real life...

      --
      sic transit gloria mundi
  5. Well. by RaboKrabekian · · Score: 5, Insightful

    While this is neat and all, and it was an inevitable use of the technology - does this scream "Gattaca" to anyone else? How long before we're doing this for unborn fetuses, and aborting those with serious defects? Or choosing among the choicest embryos?

    --
    "Moderate drinking can help prevent amputated limbs" -- Abigail Zuger, NYTimes, 12/31/02
    1. Re:Well. by delta407 · · Score: 5, Funny
      How long before we're doing this for unborn fetuses
      Yeah, but how many unborn fetuses have six hundred thousand dollars?
    2. Re:Well. by RaboKrabekian · · Score: 2

      Yeah, but how many unborn fetuses have six hundred thousand dollars?

      I think the correct question is how many unborn fetuses have parents with six hundred thousand dollars who'd want to make sure they have a perfect baby.

      --
      "Moderate drinking can help prevent amputated limbs" -- Abigail Zuger, NYTimes, 12/31/02
    3. Re:Well. by RaboKrabekian · · Score: 4, Informative

      choosing to abort is possible, but Gattica like changes are not... at least as of yet.

      You make a good point, but I just want to clarify something. If I remember correctly, they weren't changing anything in Gattaca. The process described worked by choosing the best of among many embryos - resulting in once in a lifetime "super babies" every time.

      The process of reading a gene map became so easy that the world descriminated heavily against people with any possible or probably defects, even if they hadn't manifested themselves.

      That's why this news is kind of frightening.

      --
      "Moderate drinking can help prevent amputated limbs" -- Abigail Zuger, NYTimes, 12/31/02
    4. Re:Well. by Scrameustache · · Score: 2

      I was with right up until the word "dissatisfied".
      Abortion because you lnow your kid will be crippled is a good thing, abortion because you're trying to have green-eyed kids isn't.

      --

      You can't take the sky from me...

    5. Re:Well. by drudd · · Score: 2

      The only problem with self-selection like this is humans tend to select for silly and trivial traits... resulting in highly-arthritic and frankly pathetic breeds like the poodle.

      Doug

      --
      Venn ist das nurnstuck git und Slotermeyer? Ya! Beigerhund das oder die Flipperwaldt gersput!
    6. Re:Well. by RaboKrabekian · · Score: 2

      This kind of artificial selection has been used for millenia to breed cats and dogs... maybe this is just how the human race will evolve to the next evolutionary plateau.

      True, but the difference here is that nature was doing the selecting, not Joe Daddy who wants his son to be a pro basketball player. Which, by the way there isn't anything wrong with - of course parents want the best possible opportunities for their kids. If I had children I'm sure I'd want them to have the best possible tools for they're life.

      The point is, are we ready to grant this kind of power?

      Who says a race of rich, superhuman babies is a bad thing anyway. ;-)

      Amen, brother :)

      --
      "Moderate drinking can help prevent amputated limbs" -- Abigail Zuger, NYTimes, 12/31/02
    7. Re:Well. by bakes · · Score: 2

      You are both right. Kind of. In Gattaca they chose the healthiest embryo, and implanted that one - but the others were left to die. This is not the same as abortion, since those embryos left to die may not have implanted or may have naturally aborted themselves anyway, but depending on your ethics/opinions on the matter it might be considered as just the same.

      --
      Ho! Haha! Guard! Turn! Parry! Dodge! Spin! Ha! Thrust!
    8. Re:Well. by Detritus · · Score: 3, Informative

      Eugenics was a popular political/social movement in the United States before World War II. Margaret Sanger, one of the founders of Planned Parenthood, was an advocate for eugenics. The movement never recovered from the backlash caused by the atrocities committed in Nazi Germany.

      --
      Mea navis aericumbens anguillis abundat
  6. Be that as it may.. by fadeaway · · Score: 2, Insightful

    ..there's still no gene for fate.

    1. Re:Be that as it may.. by 3141 · · Score: 2

      Randomness doesn't exist

      Tell that to a decaying atom.

  7. Top-secret information? by wmspringer · · Score: 5, Insightful

    Now here's something you don't want your insurance company getting their hands on....

    Increased risk of cancer? Sorry, not covered...

    Increased risk of alcoholism? Those driver's insurance premiums just doubled..

    1. Re:Top-secret information? by Tablizer · · Score: 2

      (* To keep insurance companies from discriminating based on your genes, we would need a consumer protection law that would mandate that health insurance providers must provide health insurance at an equal cost to all persons of a giving age and gender. *)

      What keeps a potential employer from sending your dandruff scrapts to an offshore lab and finding out all kinds of dirt on ya? For example, predisposition to mental illnes, health risks that may mean lots of absenses, and who knows what kind of personality factors they will be able to find someday.

  8. "MAPS TO CELEBRITIES GENES.....$2.00" by Thatto · · Score: 5, Funny

    "Ever wonder which hollywood stars and starlets share common sequences?" Oprah's grandmother's dirty little secret!" "THE RICH AND POWERFUL: Genetically Inclined?"

    no thanks

    1. Re:"MAPS TO CELEBRITIES GENES.....$2.00" by Tackhead · · Score: 2
      > "Ever wonder which hollywood stars and starlets share common sequences?" Oprah's grandmother's dirty little secret!" "THE RICH AND POWERFUL: Genetically Inclined?"
      >
      >no thanks

      OK, I wouldn't pay $600K for it, but I'd pay $60 to get a few gigs of data and type:

      $ cp /home/Tackhead/genemap /home/h0tbabe/genemap

      As a geek and heavy Slashdot reader, I'm reasonably confident that this is the only way my genes will ever propagate.

      (Hell, this is the only kind of gene propagation I'm interested in. Who the fsck wants to deal with a squalling brat with p00py diapers when there's fragging to be done, dammit? Think lifestyle issues, man, lifestyle! :-)

  9. Discoveries? by Galahad2 · · Score: 5, Interesting

    What happens if this guy finds the cure for cancer in your DNA? Is it your property? Same goes for lesser things, like a really good example of a gene. Is furthering the scientific community not optional?

    And the same question goes for if someone gets your DNA from a hair you dropped, and makes some discovery through that. What rights do you have over your own genetic makeup?

    1. Re:Discoveries? by Dthoma · · Score: 3, Informative
      "And what happens if someone takes a nude picture of your sister without her permission and makes a million from it? Does he own the pictures and the money? What rights does your sister have?"

      AFAIK, in Britain, the photographer owns the photos and can do whatever they like with them as long as it's not libellous.

      --

      Note to M1-ers: a curt but otherwise insightful message is not "Flamebait" or "Troll".

    2. Re:Discoveries? by jgerman · · Score: 2

      I'd imagine that if someone found something like the cure for cancer in your DNA, you'd lose your rights to it pretty quickly (assuming you ever had them). It would seem to me that for the good of everyone else in the country (world for that matter) the government would use something along the lines of immiment (sp mistake I know) domain. And in that case more power to them, if I couldn't get my cancer cured because some asshole wanted a million dollars a pop I'd be pretty pissed.

      --
      I'm the big fish in the big pond bitch.
  10. Absolutely. by neksys · · Score: 2

    The neat thing is, the price of this can only come down. I can't see it being cheap enough to be covered by health care (in countries that have such a beast), but imagine being able to plonk down $5000 or so to have your genome mapped - you could then know what to expect not only in your life, but what to expect for your children, especially when both you and your spouse have the same test done. I firmly believe that pre-emptive medical scanning - that is, determining and eliminating the possibility of a given illness before it occurs - will be one of the major scientific breakthroughs of our time.

  11. someone had to say it by Jucius+Maximus · · Score: 2
    "I firmly believe that pre-emptive medical scanning - that is, determining and eliminating the possibility of a given illness before it occurs - will be one of the major scientific breakthroughs of our time."

    Two words:

    Holy Gattaca!

  12. Money is no object by tmark · · Score: 5, Interesting

    I just can't believe how amazed people here are that someone would charge $621K or whatever to have their genome mapped. This is something that had not even been done for any human barely 2 years ago, and then only at the HUGE expense to governments all over the world, and now you can get it done for less than a million dollars ? Do these people realize how immense is the enterprise they can buy now, for less than a lot of houses that dot-commers were buying in the Bay area that same 2 years ago ?

    And many of these are the same people who probably ooh-and-ahh at anime cels costing tens of thousands of dollars, or who dream of plans spending tens of thousands of dollars wiring their house with the latest optical-this and wireless-that.

    People have spent far more money in far sillier ways.

    1. Re:Money is no object by guttentag · · Score: 2
      I just can't believe how amazed people here are that someone would charge $621K or whatever to have their genome mapped. This is something that had not even been done for any human barely 2 years ago, and then only at the HUGE expense to governments all over the world, and now you can get it done for less than a million dollars ? Do these people realize how immense is the enterprise they can buy now, for less than a lot of houses that dot-commers were buying in the Bay area that same 2 years ago ?
      The reason people are amazed that folks are paying over $600,000 for this is that it has no value for the vast majority of them. You can't definitively say when you're going to die, what diseases you're going to get or whether your kids will be criminals based on this. It has value to the scientific community, but none to the people who are paying for it.

      What are they going to do? Put it up on their mantle and point to it when they have company? That's exactly why most of them are doing this:

      "You know... that's my DNA over there. Yeah. Had myself sequenced... because... I'm cool like that. Yeah. Did I ever tell you about my plan to replace the Internet... with modems? Yeah."

    2. Re:Money is no object by gad_zuki! · · Score: 2

      Agreed, its no secret that people growing up in the information age are pretty cynical when it comes to technological advances. If it isn't cheap and effective and available with overnight shipping or instantly downloadable then it might as well not exist for them. I know this is a good sized generalization, but taking things for granted is the status quo. I'm still blown away by a lot of 'ordinary' information age marvels like globally-accesible self-publishing and cheap broadband.

      Not to mention any new tech needs early adoptors to pay through the nose so the rest of us can pay next to nothing and take it for granted later. These millionares could buy a really nice yacht or another home with this kind of cash. I think their investments are very much justified. Genome decoding isn't crackpot science, its advancing and this information will simply be priceless once the science matures in the near future.

    3. Re:Money is no object by Saeger · · Score: 2
      today there's no real use for it, but what about in 10 years?

      In ten or fifteen years I'd expect these same multi-millionaires to be among the first paying for a much more valuable "Brain Map". Wouldn't you much rather know how each and every one of your neurons is interconnected, NOW, than know your DNA's seed-AI sequence to grow a new blank one? I would.

      I know it seems crazy to think about, but biological genes won't really mean much to post-humans. Eventually every atom in my body (and in the solar system) will be brain substrate.

      --

      --
      Power to the Peaceful
  13. Venter's DNA by morcheeba · · Score: 5, Funny

    Craig's company Celera was mapping a suposedly anonymous genome, but then craig admitted it was his dna. As a Celera shareholder, I wonder if that qualifies as a $600k perk that he got.

  14. This highlights a huge conflict coming by MichaelPenne · · Score: 2, Interesting

    in the the 21st century.

    We'll experience a revolution in biotechnology and it's ability to give folks longer, healthier lives.

    But many or the treatments will be very expensive.

    At what point does being denied a cure for a disease due to poverty equal being denied the right to life?

    Or do we just accept that the rich will live years, maybe decades, longer than the rest of US?

    1. Re:This highlights a huge conflict coming by Tackhead · · Score: 2
      > How much longer will the rich have to live before ordinary folks get really p**d off, do you think?
      >A decade? (you're right, probably already there when accidents are corrected out)
      > 2 decades?
      >3?

      Yep. Damn those "rich" people for funding companies like Celera. Damn them to hell! Damn those big pharmaceuticals! Smash capitalism forever!

      Life was so much more effective 400 years ago, when the average life expectancy was around half of what it is today.

      Yes, I can see your utopia coming true in 30 years. I have visions of a small group of illiterate former humans scrabbling through the ashes of what was once a laboratory. I see one of them picking up a gene sequencer. I see him using the gene sequencer to advance his tribe's position.

      Of course, he's using it by shoving it out a broken window so that it lands on top of a neighboring tribe's leader, crushing his skull like a bug. But hey, at least you got rid of capitalism, huh?

    2. Re:This highlights a huge conflict coming by Tackhead · · Score: 2
      > So you see no problem with a rich person living for 3 or more decades longer than a poor person? No conflict there with the "inalienable rights" guaranteed to all?

      The inalienable right is to purchase one's own medical care with wealth one has acquired through productive work.

      You have a right to purchase whatever medical care you can with the dollars you earn, as do I, as does Bill Gates.

      The medical care I purchase won't be as good as what Gates purchases. If it's not good enough for me, I have the right to do without or save my money. I may not like Bill very much, but I fail to see how I have a right to take money from Mr. Gates to fund my purchase.

      > BTW, why are you assuming I'm attacking capitalism? Does "capitalism" require a huge difference between the rich and the poor? Does capitalism require that the rich live much longer and healthier lives than the poor?

      I base the assumption on my observation that most who view society as being composed of "the rich" and "ordinary folks" tend to oppose capitalism.

      In answer to your questions, (wide wealth gap, rich living longer/healthier) no and no. Capitalism doesn't require these things at all, although I'll admit that these things typically result alongside capitalism.

      The problem is, any system that prohibits these things is antithetical to capitalism. I've got nothing against encouraging charity, for instance, as a way for a rich guy to get rid of money he doesn't want. But that doesn't prevent wealth disparity under capitalism, since someone else is always free not to donate.

      In order to prevent such disparities, eventually someone's gotta pick up a gun and say "Yo, Gates. Too much money. Too many toys. Too high a standard of living. You're giving that money to charity or we're taking it from you."

      I don't have a problem with charity, but I do have a problem with picking up a gun and pointing it at someone and taking his stuff.

      > Finally, what is the point of your dystopic vision of a post-nuclear world? Are you saying that the only choice available is accepting gross divisions between rich and poor or nuking the place?

      OK, guilty as charged of hyperbole. :)

      But that's not too far from we lived up until the Renaissance and the Industrial Revolution. If it weren't for rich folks funding investments in order to please themselves ("Yo, Mike-lo, paint my chapel ceiling, something with lots of cherubs!" and "Hey, that steam engine hooked up to a spinning wheel and another one hooked up to a loom could replace a lot of manual labor"), that's pretty much where we'd still be.

      Witness the former Soviet Union - in their failed attempts to achived socialist utopia, 70 years after "ordinary folks got p***ed off at the rich", all they have to show for it is some good, cheap, reliable heavy-lift vehicles (originally designed for lobbing nukes, not space exploration), a best-on-the-planet biowarfare programme, and a life expectancy not too far removed from that of 300 years ago.

      You can argue that "pure Capitalism" is an unreachable ideal, just as "pure Communism" is unreachable. (And I'd agree with both sentiments.)

      But if you compare standards of living around the world, you'll find that "the poor" have done a damn sight better under countries with (flawed as they inevitably are) implementations of Capitalism versus any other social system.

      Someone living on welfare in America today probably a higher standard of living (more toys, more food, refrigeration, better health care) than most of our grandparents. And as far "living longer and healthier" goes, 400 years of capitalism have left him better off than most kings of the 1600s.

    3. Re:This highlights a huge conflict coming by Tackhead · · Score: 2
      > [ life, liberty, pursuit of happiness ] So to return to the context, is denial of medical care a violation of an American's right to life?

      When I (through voting for representatives who will pass laws that authorize the IRS to) take $1000 out of Bill Gates' pocket to buy me medical care that I couldn't otherwise afford, who's being denied medical care?

      The crux of our disagreement is on the notion of "right" is.

      So - in my view - Bill's got the "right" to buy medical care, and so do I. His purchase of a CellGenomix SuperGeneHacker2048 to give himself another 10 years of life doesn't affect my right to do the same thing. Bill's right to an SGH2048 denies me nothing.

      (Yes, this argument smacks of "Bill Gates has as much right to sleep in a cardboard box as any homeless guy" :)

      But I fail to see by what "right" I can take $1000 of Bill's money to buy myself a Ronco Gene-o-matic at WalMart that gives me an extra week or two, and in so doing, deny Bill the right to spend $1000 on the upgrade to an SGH2049?

      > Uh huh. In any event, it doesn't take guns (unless Gates decides to fight), it takes a majority in Congress

      You mean, if I ignore what a majority of Congresscritters write on a piece of paper, nobody with guns will come and take me away?

      When did this happen, and why didn't someone tell me?!? This is so cool! I no longer have to pay any taxes at all, and I'm gonna start distributing DeCSS, and I'm gonna set up a big P2P MP3-sharing network, and...

      Oh, wait. There's some folks with guns at my door telling me to stop all that.

      Or do you mean that Gates shouldn't (in some moral sense) fight when his rights are violated. In which case, I suppose the DMCA is also just and fair and proper.

      (FWIW, I comply with the DMCA for the same reason I do with the tax laws -- not because I believe them to be moral or just, but because it's more expensive, in terms of guys with guns making my life miserable -- to resist than to comply. Bill, on the other hand, might actually be rich enough, and Congress might be dumb enough, to pass tax laws where it would be cheaper for him to build an island outside territorial waters and raise an army of clones to defend it. YMMV. :-)

      > So you think that if the rich live for say 30 years longer than the poor, the poor will still feel ok with it because they live longer than the kings of the 1600s? Or because they still live longer than the warlords in Sudan? How about if the rich live 50 years longer?

      You're saying you'd rather live in this world:

      1) Tack and Mike live to 90. Bill lives to 120.

      ...than:

      2) Tack and Mike live to 100. Bill lives to 150.

      ...even if the net effect of your choosing #1 over #2 is that nobody builds gene-hackers because there's no profit in it. (This would be much like how we still don't have a Malaria vaccine, because those who would benefit most can't afford it). That leads to an increased probability of the status quo:

      3) Tack and Mike and Bill live to 80.

      I dunno about you, but I'll be quite happy the extra 10 years from door #2, even if it means we all have 20 more years of Outlook worms to deal with :)

  15. Re:Of course results may vary... by saskboy · · Score: 2, Insightful

    I think this would be one of the best investments a person could make. Too bad it will be all of rich people, which will skew the results of any statistics that could pop out of the research. All super rich people must have a gene or two that supplies an aggressive desire for money, and stupid gold digging mates.

    --
    Saskboy's blog is good. 9 out of 10 dentists agree.
  16. Doesn't that kind of take the fun out of life? by Mustang+Matt · · Score: 2

    I guess it could be fun to cheat death if you found out about something you had before it affected you.

    --
    The man who trades freedom for security does not deserve nor will he ever receive either. - Benjamin Franklin
  17. I already own this... by stuffman64 · · Score: 4, Insightful

    Why would I pay for something I already own?

    Sure, it would be nice to know in advance if I am susceptible to getting diabietes like my grandmother, or heart disease like most of my mother's side of the family. However, if I do all I can to be healthy (i.e., not eating junkfood while laying on my couch all day), there is a significantly less chance of my being afflicted by these ailments. Some things could not be prevented, but I already know I have them (depression, bad eyesight).

    If people spend their "pocket change" on this, they may be in for a suprise. They may find that they have the genes for an increased risk of myocardial infarctions (heart attack), but because they have neglected thier health, they may find it hard to change thier lifestyle to a more healthy one. Although many health-related problems cannot be avoided (for instance, Huntington's Disease, which usually doesn't show up untill your 30's), many diseases that you may be high-risk for can be prevented with a proper lifestyle.

    --
    --- At my sig, unleash hell.
    1. Re:I already own this... by isorox · · Score: 3, Funny

      However, if I do all I can to be healthy (i.e., not eating junkfood while laying on my couch all day)

      I stopped that lifestyle a long time ago, I now sit in my nice comfy armchair while eating junk food, much healthier!

  18. Re:If I had $621,500... by lingqi · · Score: 2
    I'd buy something else... like a dozen dancing monkeys, a really awesome lawnmower, a whole lot of pudding, or maybe my own zombie slave.

    A Dozen Dancing monkeys? zombie slave? that's rediculous... oh wait...

    (for a little off-subject:) my 300th comment! jesus christ i wasted a lot of time on /.

    --

    My life in the land of the rising sun.

  19. Just wait 10 years.. by lunaman · · Score: 5, Insightful

    ...and your employer (or insurance company, bank, credit bureau, department of motor vehicles, Department of Homeland Defense, etc.) will do it for you FOR FREE!

    With or without your permission.

    Perhaps by then someone will offer a service where you can pay your $600K to PREVENT everyone from getting your gene sequence...

  20. How big is my source? by geoffeg · · Score: 3, Interesting

    How big would the resulting data be? In the meg's, gig's? Would it compress well?

    It would be cool to be able to carry around your own genome on a little CDROM in your wallet or purse.

    Geoffeg

    1. Re:How big is my source? by mbessey · · Score: 4, Interesting

      Let's see. Three billion base pairs, at approximately two bits of information per base pair = 6 billion bits, or about 750 Megabytes of raw data.

      It'll probably compress very well, since most of the sequences correspond with either Amino Acids or control codes of one sort or another.

      Probably smaller than the source code to your favorite Linux distribution, overall...

      -Mark

  21. better things to do with that money? by GoatPigSheep · · Score: 2

    Imagine how many starving children could be fed if those millionaires donated the $621,500 to charity instead of getting their genes mapped and finding out what illness might kill them.

    Oh well, like it would ever happen.

    --
    GoatPigSheep, the 3 most important food groups
    1. Re:better things to do with that money? by Tackhead · · Score: 2
      > Imagine how many starving children could be fed if those millionaires donated the $621,500 to charity instead of getting their genes mapped and finding out what illness might kill them.

      Imagine what a wonderful world we'd have if the millionaires of 50-60 years ago had given the money to charity instead of investing in companies that mass-produced cheap effective vaccines against diptheria, tetanus, polio and smallpox.

  22. Comment removed by account_deleted · · Score: 2

    Comment removed based on user account deletion

  23. It's really not much data at all by mbessey · · Score: 3, Interesting

    We're only talking about 6 billion bits or so. You'd need about 2 CD's, if you didn't compress it at all.

    -Mark

  24. Leelee Sobieski... by Nathdot · · Score: 2

    Rumour/IMDB-Trivia has it that Leelee Sobieski collects locks of hair from major stars appearing with her in films.

    So if anybody wanted to buy themselves a prime bevy of Hollywood DNA to make gene maps from (for whatever nefarious cloney-type purposes) she'd be the person to see. :)

    PS. A clone army of Leelees would be nice too

  25. EULA by DeadBugs · · Score: 2

    It would be funny to deliver Bill Gates his "Gene Map" with a restrictive End User License Agreement.

    --
    http://www.kubuntu.org/
  26. For only $160 by Anonymous+Squonk · · Score: 2

    You can check out your ancestry as coded in your DNA, specifically what percentage Caucasian, African, etc. you are.

  27. Ironically enough... by glwtta · · Score: 3, Insightful

    ... he got paid to sequence his own. Go figure.

    --
    sic transit gloria mundi
  28. I want to find out... by frank_adrian314159 · · Score: 2

    ... where the Bill Gates' money gene is. Unfortunately, the subsequence that accounts for it probably expresses the lack of business ethics characteristic, as well.

    --
    That is all.
  29. Comment removed by account_deleted · · Score: 2

    Comment removed based on user account deletion

  30. Re:I already own this... [so?] by stuffman64 · · Score: 2

    hmm... thanks for the personal attack. I don't mind my ideas being criticized, but they don't make me lame... anyways...

    The difference between this and, say, a credit report is that the credit report is not part of you. It may describe your lack of paying bills, but it only describes a quality of you.

    On the other hand, your genome is you. It is what you are - who you are. Credit reports created, modified, and under certain circumstances, destroyed. The information in them changes, so it is necessary to check on it from time to time - the same way you buy current newspapers as opposed to the same issue every day. Your genes are, for the most part, static. They are with you from the time your dad's sperm met with your mom's egg. Credit reports and school transcripts are explicit properites of you, but your genome is implicit.

    I'm not arguing with you about the service aspect of this; after all, it is just as much of a service as getting a copy of your credit report. It is just the content that I see differently

    --
    --- At my sig, unleash hell.
  31. A nice comparison by tfoss · · Score: 2, Interesting

    I was at a lecture given by Leslie Orgel (a very famous biochemist known for work on the molecular origin of life) and he made a very nice point when asked about the genome project. He likened the sequencing of it to deciphering the white pages of a phone book for a large city. If we ever work out the proteome (the collection of proteins that the genome codes for, along with post-translational modifications, binding partners, etc...which is much beyond what is specified in the genome), then we will have the equivalent of the yellow pages. Yet, even with both of these references, you could only begin to try and understand how the city (and by comparison, the cell) functions.

    So while having your personal genome might be cool in the uber-rich kind of way, the usefulness is still quite limited.

    -Ted

    --
    -=-=- Quantum physics - the dreams stuff are made of.
  32. "A close tie" by anomalousman · · Score: 3, Informative

    Actually, the constant media harassment was irritating them, so the two parallel (public/private) projects declared the gene to be sequenced BEFORE either project was complete.

    The enormous media frenzy that happened as a result took up some extra time, but enabled them to get back to the science in peace - with extra funding in several cases.

  33. Re:Interesting, but.. by Dthoma · · Score: 2
    "Like the article says, there are no real practical uses for this."


    Except suckering rich people out of $600K and getting to get your own private copy of their DNA.

    --

    Note to M1-ers: a curt but otherwise insightful message is not "Flamebait" or "Troll".

  34. It was inevitable... by tlambert · · Score: 2

    It was inevitable... Microsoft makes people pay for their beta's, and now Celera is making people pay to provide them with more information about the human genome, which would have otherwise cost them $600k a pop to sequence out themselves.

    I think this is a good thing, since they will drive down the price, and they will get a broader information base than just Ventner's own genes: what's been sequenced is *a* human genome, not *the* human genome.

    On the privacy side of things, I'd just as soon keep the contents of my chromosomes to myself (particularly 6, 11, 12, 17, 21, and 23), thanks, but that said, I'd like to read it myself and compare it to statistical data, without anyone looking over my shoulder, or writing my name down in a database next to the information.

    -- Terry

  35. Re:Proper lifestyle? by stuffman64 · · Score: 2

    I shouldn't have been so vague in my use of lifestyle. By it, I don't just mean diet and excercise (although it helps). Lifestyle includes state of mind and environment. You could eat well and excercise, but if you live in a run down double-wide and be so depressed that you want to shoot yourself. Generally, I would not consider this a healthy lifestyle.

    --
    --- At my sig, unleash hell.
  36. Not Funny by foo+fighter · · Score: 3, Funny

    I see alot of comments joking about already owning their gene map and about releasing their map under the GPL.

    No, you don't and no, you can't.

    Most of the genes in your body are already patented, trademarked, and/or copyrighted. Those that aren't will be within the next few years.

    We don't own our own bodies.

    I hope that literally scares the shit out of you. It did to me: I locked myself in my bathroom until I could cope with the insanity of some corporation owning the natural devices that construct humans.

    Wired had a very informative article on this some time back. Also, you can Google for the info and you'll find it.

    What really scares me is that I've got at least 80 years left to live. I'm going to be fighting and putting up with a lot of shit before I can finally rest.

    It'd be nice if some of you would give me a hand.

    --
    obviously no deficiencies vs. no obvious deficiencies
    1. Re:Not Funny by Dirtside · · Score: 2

      I thought that what those biotech companies had patents on was methods for testing for the presence of particular genes. That's markedly different than owning a patent on a gene itself.

      --
      "Destroy science and religion. Science would re-emerge exactly the same; but not religion." - Penn Jillette, paraphrased
  37. In the undying words of Bender: by RPoet · · Score: 2

    "There! Now no one can say I don't own John Larroquette's spine!"

    --
    "Oppression and harassment is a small price to pay to live in the land of the free." -- Montgomery Burns.
  38. Moore's Law of gene analysis by peter303 · · Score: 2

    Because gene analysis is mainly an information enterprise, it will follow Moore's Law and drop a zero in price every five years or so. The first reason is that gene analysis is computer intensive. Celera and the Human Genome Project own some of the largest computer complexes in he world for reassembling shotgun gene pieces. Thus gene analysis will piggy back computer advances.
    Second, gene analysis is getting smarter. Coding genes only occupy 2% of the genome. Of this, only 0.1% differs between individual beings. this cuts the analysis problem from 3.2 billion bases to about 100,000 bases. Mapping which 100,000 bases are important is the next stage of technology.
    In summary, instead of a month and $600K, in 20 years your should do this in an hour for $50.

  39. Beyond This Horizon by HiThere · · Score: 2

    I don't know Gattaca, outside of having the vague notion that it was dystopian. But you might look into an old Heinlein novel called "Beyond This Horizon". He envisions a society that uses this kind of technique, but which is also quite libertarian. (Mind you, he was quite down on genetic modification rather than selection...)

    The technology does not determine the kind of society. It determines the range of kinds of societies. We already have all the technical capability needed to create a truly dystopian society, and we have had it for decades. (We seem to be edging that way, but certainly not at a rate limited by technical capabilities.)

    --

    I think we've pushed this "anyone can grow up to be president" thing too far.
  40. Re:old question by Tackhead · · Score: 2
    > This kind of reminds me of an old question I used to go around asking people: Would you rather know the date of your death, or the method of your death?
    >
    > Inevitably, most people would stumble around a bit, and then finally settle on "neither", because nobody wants to live knowing that they'd only have 10 or so years left or this world, nor knowing that each time they stepped on an airplane could be their last.

    I'll buy the argument for "method" but have never understood the argument for "date". If we assume our fate is predetermined (which we have to, for the question is meaningless without it), why wouldn't anyone want to know the date of their death?

    If I have 80 years to go, I can invest long-term, and should probably keep my current job for another decade or two.

    If I have 10 years to go, I can either work for another 5 years and live for 5 years of a moderate party lifestyle, or retire tomorrow and read Slashdot and play CounterStrike for the rest of my days.

    If I have one year left, I can tell my boss to eat my shorts now, buy a Ferrari and a couple of hookers tomorrow, and haul ass across America, leaving a trail of burned rubber, pissed-off cops, 10-20 dead Black Angus cattle, and 200 very happy bartenders in my wake. W00T!