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Humanity Gene Found?

Banana_Republican writes "Nature is reporting that that multiple copies of a mystery gene may be what makes us human. It appears that humans have multiple carbon copies of a recently discovered gene that other primates lack. In particular, one sequence not so romantically or emotionally termed 'DUF1220' was mentioned . Humans carry 212 copies of DUF1220, whereas chimps have 37 copies, and monkeys have only 30 copies. Apparently the current thinking is that this gene is responsible for coding important areas of brain function."

231 comments

  1. Splice the genes into monkeys by Anonymous Coward · · Score: 1, Funny

    and commence with Planet of the Apes.

    1. Re:Splice the genes into monkeys by legoburner · · Score: 1

      So long as the monkey is named Gunther and has a stylish hat. He'll probably only eat "banana-flavored energy bars made from tofu". Damn I'm glad Futurama will be back next year.

    2. Re:Splice the genes into monkeys by Anonymous Coward · · Score: 0

      2008 is the tentative date for it. So a year and a few months, at best. More than two, at worst.

    3. Re:Splice the genes into monkeys by rshane · · Score: 1

      You maniacs! You'll blow it up!

      --
      Shane
  2. They couldn't have come up with a better name.... by BlahMatt · · Score: 1

    because I'd rather not be human because of something called DUF (and no... the 1220 on the end doesn't help).

    --
    To understand recursion, one must first understand recursion...
  3. Oh well, so much for the by Travoltus · · Score: 0

    "So what's the difference between a monkey fetus and a human fetus? Huh? Huh?!!!" argument.

    --
    --- Grow a pair, liberals... stop letting the Republicans bully you!
    1. Re:Oh well, so much for the by Kesch · · Score: 1

      Duh! Only one of them has a soul. Aborting monkey fetuses isn't murder. /sarcasm off

      --
      If this signature is witty enough, maybe somebody will like me.
    2. Re:Oh well, so much for the by thefirelane · · Score: 2, Insightful

      Your post confuses me... did anyone ever think there was no genetic difference?

    3. Re:Oh well, so much for the by Bull+SR · · Score: 1

      A US Presidential candidate insults one by calling it by the genus name of the other.

    4. Re:Oh well, so much for the by Anonymous Coward · · Score: 0

      Obvious: One grows into a hairy non-sentient with foul body odor, and the other into a monkey.

    5. Re:Oh well, so much for the by fragmentate · · Score: 1
      So what's the difference between a monkey fetus and a human fetus? Huh? Huh?!!!

      187

    6. Re:Oh well, so much for the by fragmentate · · Score: 1
      Or 182, depending on if you do Monkey math, or Human math...

      Duh!

      "Proofreading is your friend." - fragmentate, circa 2006.

    7. Re:Oh well, so much for the by Anonymous Coward · · Score: 0

      the monkey's is easier to throw.

      oh, wait, you wrote fetus and I was thinking feces.

      I FLING POO!

    8. Re:Oh well, so much for the by Descalzo · · Score: 1
      187

      Which brings us back to murder.

      --
      I cried real tears when Li Mu Bai died.
  4. Duh by john83 · · Score: 2, Insightful
    Apparently the current thinking is that this gene is responsible for coding important areas of brain function.

    Fantastic. Unfortunately, that seems to come from the same school of thought as my suggestion here: this gene is responsible for male pattern balding and fully erect bipedal motion.

    --
    Strange women lying in ponds distributing swords is no basis for a system of government.
    1. Re:Duh by Kesch · · Score: 3, Funny

      Hee hee! He said erect. *snicker*

      This post brought to you by Humans, the only organism known to make childish penis jokes. (Some Slashdotters belive DUF may be involved.)

      --
      If this signature is witty enough, maybe somebody will like me.
    2. Re:Duh by Anonymous Coward · · Score: 2, Funny

      I sometimes have problems with bipedal motion when I'm fully erect.

    3. Re:Duh by dosun88888 · · Score: 1

      There's nothing childish about my penis, so stop making jokes about it.

    4. Re:Duh by fuego451 · · Score: 1

      Yeah, tripedal locomotion isn't easy to master. Especially under the influence of DUF.

    5. Re:Duh by Anonymous Coward · · Score: 0

      As opposed to the sophisticated penis jokes made by lemurs.

    6. Re:Duh by Anonymous Coward · · Score: 0

      So two lemurs, a chimpanzee, and the pope walk into a bar...

    7. Re:Duh by Anonymous Coward · · Score: 0

      Except when viewed by your life partner.

  5. interesting by Anonymous Coward · · Score: 0

    "And they know that the gene makes a protein that is found in the human brain. That suggests that it may help to give the human brain its unique ability to think and reason, they say. "

    Interesting conclusion there...

    1. Re:interesting by Anonymous Coward · · Score: 1, Interesting

      Further in the article, the statement gets a bit weaker:

      "When the team looked for the protein in the human body, they found it in many places, including in neurons in the brain."

      What can you expect from a former Newsweek reporter? Even if she is hot.

      http://www.nature.com/news/about/aboutus.html#Chec k

  6. Carbon copies? by Bob+Cat+-+NYMPHS · · Score: 1

    What are those?

    Don't they copy A T C G too?

    1. Re:Carbon copies? by elgee · · Score: 5, Funny

      I guess they don't have DRM. Good thing as if it were up to the RIAA, there would only be one human.

  7. Here it comes... by Anonymous Coward · · Score: 0

    Cue the Simpsons Duff Beer jokes!

  8. Duff by neurostar · · Score: 1

    Homer simpson anyone?

    1. Re:Duff by eno2001 · · Score: 1

      Homer Chimpson actually...

      --
      -"...bad old ideas look confusingly fresh when they are packaged as technology" - Jaron Lanier (Digital Maoism on Edge.o
    2. Re:Duff by cemcnulty · · Score: 1

      Duf gene for you
      Def gene for me
      I'll have a Duf
      You have one too!

  9. Mmmmmm.... DUF by HaeMaker · · Score: 2, Funny

    Homer must be saying, "Told you so. We are not human without DUF".

    1. Re:Mmmmmm.... DUF by Anonymous Coward · · Score: 0

      weak. so weak...

    2. Re:Mmmmmm.... DUF by StarfishOne · · Score: 1

      Doh, doh.. initially I read: "We are not human without ODF"

  10. Radio Shack by Johnny+Mnemonic · · Score: 1, Funny

    How many copies of this gene did the fire-by-email Radio Shack managers have?

    --

    --
    $tar -xvf .sig.tar
  11. DUFF MAN SEZ: by Anonymous Coward · · Score: 0

    DUF1220, it makes you feel human... Drink up!

  12. Re:They couldn't have come up with a better name.. by john83 · · Score: 1

    Duf, Duf that wonderful stuff...

    --
    Strange women lying in ponds distributing swords is no basis for a system of government.
  13. I can see the bumper stickers now... by mpoulton · · Score: 3, Funny

    "My honor student has more copies of the DUF 1220 gene than yours!" and "Got DUF1220?"

    --
    I am a geek attorney, but not your geek attorney unless you've already retained me. This is not legal advice.
  14. Obligatory reference to super-brained chimps by coolgeek · · Score: 3, Funny

    "Good news everyone"

    --

    cat /dev/null >sig
  15. My mistake by svunt · · Score: 1

    Boy, is my face red. All this time I've been using tails and fur to distinguish between humans and other primates, when DUF1220 was the key.

  16. Re:They couldn't have come up with a better name.. by OakDragon · · Score: 1, Redundant

    DUFF? All I can say is: WOO-HOO!

  17. Don't forget human antigenes by Baldrson · · Score: 4, Interesting

    Although there are some critical genes for expression of human characters, one of the characteristics of rapid evolution seems to be the inactivation of genes. As you progress along the line to humans there appear to be fewer and fewer genes being expressed. This seems to be the result of mutation's default action which is to damage gene function which in general means to deactivate it. Its a lot easier to deactivate a gene than it is to create a gene with positive action. So you can expect that if there are ways to create positive characters at the phenotype level by deactivating genes that would be main way those characters emerge during the early stage of evolution. It is probably also be that some older genes need to be silenced to so that newer genes that actually do function can express less competition.

    1. Re:Don't forget human antigenes by andyr · · Score: 2, Interesting

      I heard that cancer was the oldest disease, and the careful countdown of cell generations from stem cells was precisely to keep the wart on the frogs bum from taking over the frog. Once you have licked cancer, the rest becomes manageable.

      --
      Andy Rabagliati
  18. Speaking of Bars by iluvcapra · · Score: 4, Funny

    Can't get enough of the wonderful DUF.

    --
    Don't blame me, I voted for Baltar.
  19. Re:Obligitory Monkey Joke by MagicM · · Score: 0, Flamebait

    Wow. Doubly offtopic. Once for the lame joke, and once because you're pimping your website.

    At least put the link in a signature. The fact that you've already set it as your homepage should be enough.

    Please.

  20. Humanity just can't get enough... by Anonymous Coward · · Score: 0

    ...of that wonderful DUF

    "Beer, the cause of, and solution to, all of life's problems"

  21. DUF1220 slashdot handle by lems1 · · Score: 5, Funny

    Ok, this was going to be my new name in Slashdot but some bastard already registered it!

    --
    This sig can be distributed under the LGPL license
    1. Re:DUF1220 slashdot handle by dUf1220 · · Score: 5, Funny

      ha ha! foiled you!

    2. Re:DUF1220 slashdot handle by dUf1220 · · Score: 2, Funny

      ha ha!

    3. Re:DUF1220 slashdot handle by dUf1220 · · Score: 4, Funny

      ha ha! (you get the point)

    4. Re:DUF1220 slashdot handle by lems1 · · Score: 1

      bastard! lol

      --
      This sig can be distributed under the LGPL license
    5. Re:DUF1220 slashdot handle by Anonymous Coward · · Score: 0

      Bah! Your UID is still 6.12953628414... times as big as his, newb.

      (does anybody else think lems actually got the name, but claimed he didn't to make the joke?)

    6. Re:DUF1220 slashdot handle by jafac · · Score: 1

      Ah, now if only I could transfer that name to my spiffy 4-digit user id. . .

      --

      These are my friends, See how they glisten. See this one shine, how he smiles in the light.
    7. Re:DUF1220 slashdot handle by lems1 · · Score: 1

      lol

      nah. I didn't even try to get the name but just made the joke. ask the bastard who took the joke if he registered it after i said it or as soon as the article came out.

      my uid is already more than 5 digits long...

      --
      This sig can be distributed under the LGPL license
  22. That makes sense. by RyanFenton · · Score: 0

    Really, it makes sense. Patrick Duffy is what makes us truly human, after all.

    Ryan Fenton

  23. Can't get enough... by decipher_saint · · Score: 0, Redundant

    ...of that wonderful DUF!

    --
    crazy dynamite monkey
  24. DNF1220! by __aaclcg7560 · · Score: 0

    ... one sequence not so romantically or emotionally termed 'DUF1220' was mentioned.

    For a moment, I thought it was "DNF1220". The possibility that a copy of Duke Nukem Forever had time traveled back to 1220 B.C. to infect the human gene pool is too horrible to imagine.

    (As a tester on "Duke Nukem: Land of the Babes" for PSX, where Dukie time travels to future and does a Bill Clinton at the White House, this scenario isn't too far fetch to imagine. Blame my genes!)

    1. Re:DNF1220! by Kesch · · Score: 3, Funny

      Actually, 1220 refers to the fact that it will be released 1220 years after the second coming of Christ. (*Note: This release date is tenative and subject to change.*)

      --
      If this signature is witty enough, maybe somebody will like me.
    2. Re:DNF1220! by Anonymous Coward · · Score: 0

      As the second coming of christ began in 1914 that means it will be released in 3134 AD.

      Read all about it here.

  25. Re:They couldn't have come up with a better name.. by danudwary · · Score: 5, Informative

    Not that it's going to stop all the Simpsons jokes, but DUF just stands for Domain of Unknown Function. It's not a name so much as a placeholder. There are lots of DUFs.

  26. The next step in the research. by LotsOfPhil · · Score: 1
    Apparently the current thinking is that this gene is responsible for coding important areas of brain function.
    Well, why don't they make some knockout mutants and then look at the brain function? It seems like the logical next step.
    --
    This post climbed Mt. Washington.
    1. Re:The next step in the research. by WillAffleckUW · · Score: 1

      Well, why don't they make some knockout mutants and then look at the brain function? It seems like the logical next step.

      Because humans take 16 to 22 years to develop full mental capacity. They'd be better off copying the segments into mice and making intelligent mice. I think we should call the ones with 10 segments Pinky and the ones with 220 segments Brain.

      Just make sure they don't escape from the lab and try to take over the world.\

      Also, if you thought outcries over stem cells were a bother, wait until we have adults without such segments. Some might even get elected to higher office ...

      --
      -- Tigger warning: This post may contain tiggers! --
    2. Re:The next step in the research. by FST777 · · Score: 1

      So, I suspect mice have 42 DUF-segments? That would be the answer...

      --
      Free beer is never free as in speech. Free speech is always free as in beer.
    3. Re:The next step in the research. by Descalzo · · Score: 1

      ALL of the X-Men were knockouts. Especially Psylocke.

      --
      I cried real tears when Li Mu Bai died.
    4. Re:The next step in the research. by shrinkrap · · Score: 1

      So this could be the beginning of folks with superhuman abilities? It should have been named DUF4400.

  27. It's a common mistake by RsG · · Score: 2, Funny

    In your defense, they're quite hard to tell apart once you've had a few Duffs. What look like slightly unshaven legs and sloping posture the night before reveal themselves fully in the morning after.

    --
    Erotic is when you use a feather. Exotic is when you use the whole chicken.
  28. Duh! The Homer gene by EmbeddedJanitor · · Score: 1

    Explains a few things.

    --
    Engineering is the art of compromise.
  29. Next thing we'll hear by mendaliv · · Score: 1, Interesting

    If this has any truth, we'll probably soon hear that the protein made by this gene is found primarily, or in high quantities, in areas important to language production like Broca's area or Wernicke's area.

    1. Re:Next thing we'll hear by linguizic · · Score: 1

      Or in any of the areas of the human brain that are hypertrophic homologues of chimp brains. In english: any of the areas that look like they are outgrowths of similar regions in chimp brains.

      --
      Does this sig remind you of Agatha Christie?
    2. Re:Next thing we'll hear by Anonymous Coward · · Score: 0

      There's a long string of well-reasoned arguments (from Fodor to Jackendoff and beyond) as to why our spoken languages are not the essense of our thought or intelligence. The notion that when you "witness" your "self-talk" you're hearing the machinery of mind has serious problems to it, about which long and detailed books have been out for years.

  30. er... thats a bit of a leap by gsn · · Score: 5, Insightful

    In other news the more midi-chlorians in your blood, the greater the person's Force ability

    TFA says that there is a gene that humans have more copies of than primates and that this gene makes a protein in the brain. They don't know what the protein does in the brain indeed they have no idea what having multiple copies of the gene does. Yet they reach the conclusion that this gene may be responsible for giving us our humanity.

    All they seem to have is a weak correlation between the number of this gene and intelligence (which is arguable - I know some really dumb people) and as we've all learnt many times "Correlation does not imply causation."

    IANAGS but I'd wait until there was some more evidence on offer.

    --
    Reality must take precedence over public relations, for nature cannot be fooled.
    1. Re:er... thats a bit of a leap by Daniel+Dvorkin · · Score: 5, Insightful

      All they seem to have is a weak correlation between the number of this gene and intelligence (which is arguable - I know some really dumb people) and as we've all learnt many times "Correlation does not imply causation."

      If you RTFA (I know, I know, this is /. and that's against the rules or something) you'll see that the researchers are not claiming anything except "we found this gene, humans have a lot more copies of it than monkeys, and we think that might be important." Anything else is reporter's and/or story submitter's hype.

      But there are a couple of other notes I'd like to make in response to your post, which are really responses to lots of posts of this nature. First, this is not a weak correlation; 212 vs. 37 vs. 1 is a significant difference in almost any context, and yes, we've all known some really dumb people, but unless those people are severely retarded, they're still a hell of a lot smarter than the smartest chimp or monkey. Second, I really wish people would stop invoking "correlation does not imply causation" as a mantra. Yes, it's true, but it's also true that correlation implies correlation -- by which I mean that if there is a statistically significant correlation between two variables, then it is entirely reasonable to assume that there exists some connection between them, and to use this assumption as, at the very least, a basis for further investigation.

      I think people are so used to misinterpretations of correlation (almost never by scientists, BTW) that they forget that it is still a powerful and useful tool. Actually, this is true of statistics in general. Yes, it's very easy to lie with statistics; it is somewhat harder, but entirely possible and fairly common, to use them to discover great truths.

      --
      The correlation between ignorance of statistics and using "correlation is not causation" as an argument is close to 1.
    2. Re:er... thats a bit of a leap by lubricated · · Score: 1

      This is two datapoints. The evidence for correlation is not strong.

      Two datapoints are not statistically significant, for correlation.
      Yeah, they found a gene that is alot more common in humans than monkeys. There are probably other such genes appearing by chance. They just happened to find one. They can use it as the basis for more study. Though there aren't many conclusions that can yet be drawn.

      --
      It has been statistically shown that helmets increase the risk of head injury.
    3. Re:er... thats a bit of a leap by SydShamino · · Score: 1

      And how long until we genetically engineer a monkey with, say, 200 copies of this gene?

      Uplift, here we come.

      --
      It doesn't hurt to be nice.
    4. Re:er... thats a bit of a leap by Anonymous Coward · · Score: 0

      All they seem to have is a weak correlation between the number of this gene and intelligence (which is arguable - I know some really dumb people) and as we've all learnt many times "Correlation does not imply causation."

      Right! Correlational data is completely useless, because it could mean lots of things! I mean, it's entirely plausible that being intelligent causes you to have this gene. Or that some unmeasured third variable causes both. What are these hacks thinking even running this kind of study?

    5. Re:er... thats a bit of a leap by gsn · · Score: 2, Informative

      No it isn't two data points - I have the article.Magdalena C. Popesco et. al. Human Lineage-Specific Amplification, Selection, and Neuronal Expression of DUF1220 Domains. Science 1 September 2006: Vol. 313. no. 5791, pp. 1304 - 1307
      I'd love to get a an opinion from a someone who works in genetics.

      They do claim that taken together the data from three seperate methods (BLAT http://genome.ucsc.edu/cgi-bin/hgBlat, aCGH and QPCR - I know what PCR is and I'm reading up on the others but this is not my field) they do claim that DUF1220 is "highly expanded in humans, reduced in African great apes, further reduced in orangutan and old world monkeys, single copy in non-primate animals, and absent in nonmamalian species." They've a graph of the the number they predict from PCR for different primate species and humans and though there is some spread it seems clear that humans have more DUF1220 domains than the other primate species tested again.

      However, the point remains they do not know what DUF1220 does and so saying that it leads to human traits is not very convincing. The researchers do speculate that they "may play an important role in human-lineage specific traits." So its not entirely the reporter/submitter hype. Yes I'd agree that correlation is strong basis for further investigation and thats what I asked for when I said I'd wait for there to be more evidence. Again I do not work in genetics and don't know if this is possible but it'd be a lot stronger evidence if they could implant more copies of this gene and then see that it lead to greater brain complexity or something.

      Topics like this tend to get a lot of hype and sensationalism and people jump to conclusions and I'd think it would be much better to wait until the genetics community says something strongly.

      And yes I was joking about the lots of stupid people Daniel. And yes they are a lot smarter than the smartest chimp or monkey. Though ever since I saw Project X I'm ashamed that chimps are better at Flight Simulator than me ;-D

      --
      Reality must take precedence over public relations, for nature cannot be fooled.
    6. Re:er... thats a bit of a leap by geobeck · · Score: 1

      ...correlation implies correlation...

      I think you mean "coincidence implies correlation." In other words, if two factors occur in the same place or time, it implies that they might be related somehow, even if there is no causal relationship between them. It's just as likely that the causative factor is something as yet unknown that causes both factors.

      --
      Find environmentally and socially responsible products on http://buy-right.net
    7. Re:er... thats a bit of a leap by AxemRed · · Score: 2, Funny

      There's only one thing we can do... We have to genetically engineer a child with about 800 copies and see what happens. Only then will we know the truth.

    8. Re:er... thats a bit of a leap by exp(pi*sqrt(163)) · · Score: 1

      The problem is that in this case the correlation could have a thoroughly uninteresting casuality. For all we know this could a gene that makes you like bananas. And there really isn't a solid basis for saying this is a significant correlation. If you were to look at all of the non-intelligence-related biochemical processes taking place in mice, chimps and humans, and rate them by how much activity is taking place, any number of these could be correlated with this gene. I give a potential example in another post - it might be that the disease confers resistance to some virus and that the presence of this gene is nothing more than an indicator of how suitable each organism is as a host for this virus.

      --
      Doesn't it make you feel good to know that our freedoms are protected by politicans, lawyers and journalists.
    9. Re:er... thats a bit of a leap by shawb · · Score: 1

      when a scientist issues a cuatious phrase like "may play an important role..." that basically translates into "hey, we got something that should be looked into." From there it's various layers of press trying to add a little "wow" to the article that make it sound more and more like the scientists declared that this one gene is alone responsible for the difference between chimps and people.

      *Disclaimer, some scientists may exaggerate the importance of their findings, presumably for garnering more grant money, or possibly for good old fame and attention, but that is not the experience I've generally seen when dealing with scientists.

      --
      I'll never make that mistake again, reading the experts' opinions. - Feynman
    10. Re:er... thats a bit of a leap by mcvos · · Score: 1
      IANAGS but I'd wait until there was some more evidence on offer.

      And the best way to get that evidence is through experiment: give a mouse 200 copies of that gene and see if he turns into the Brain. And then make a human with 1 copy of the gene and see if he turns into Pinky.

    11. Re:er... thats a bit of a leap by stonecypher · · Score: 1

      First, this is not a weak correlation; 212 vs. 37 vs. 1 is a significant difference in almost any context, and yes, we've all known some really dumb people, but unless those people are severely retarded, they're still a hell of a lot smarter than the smartest chimp or monkey.

      The germane issue here is best represented in the phrase "correlation does not imply causation." Indeed that there is a correlation is unimportant; this is the sort of logic that leads to people believing that the thing keeping the monkeys dumb is the hair on their bodies. Before you get all rankled, please remember that in the four measley monkey types that were tested, hair density and intelligence are in fact correlated far more strongly than this particular gene.

      Before you cry foul and say that because this is a gene that suddenly the correlation actually is important, please read up on the fallacy of the undistributed middle. All humans carry many encodings of this protien. Humans are intelligent. To suggest from those two things that things carrying encodings of this protien are suddenly smart is naïve in the extreme. Humans carry hundreds of encodings of HSV1 in our genome which cannot infect monkeys. Does that mean herpes made us smart?

      No .

      Correlation is unimportant; displaying it is an exercise in wasted time. Dicto simpliciter, sir, dicto simpliciter. You make the baby sonolumuinescence cry. I want to knock you down and tattoo "cum hoc ergo propter hoc" on your spine and "post hoc ergo propter hoc" on your ribcage.

      --
      StoneCypher is Full of BS
    12. Re:er... thats a bit of a leap by egilhh · · Score: 0

      Err... Pinky? Methinks you mean Philip J. Fry...

    13. Re:er... thats a bit of a leap by Daniel+Dvorkin · · Score: 1

      Congratulations, you've shown that you can copy links to poorly written Wikipedia articles to justify your semi-coherent arguments in discussions you clearly don't understand. We could probably train any reasonably smart monkey to do the same.

      --
      The correlation between ignorance of statistics and using "correlation is not causation" as an argument is close to 1.
    14. Re:er... thats a bit of a leap by stonecypher · · Score: 1

      False dismissivity is the sad refuge of those without enough character to admit when they were wrong.

      --
      StoneCypher is Full of BS
  31. just like homer simpson.... by acedotcom · · Score: 0

    ...i am loaded with DUF

    --
    they say it is often more relevant then the comment above, all we know is its called the Sig!
  32. In other news... by Evro · · Score: 5, Funny

    RIAA and MPAA members found lacking new gene...

    --
    rooooar
    1. Re:In other news... by Anonymous Coward · · Score: 0

      ...they found another gene, called DUFUS

    2. Re:In other news... by udderly · · Score: 1

      Somehow, when I saw the /. blurb for this story, I just knew that there would be at least anti-Bush/Republican post. I just knew it.

    3. Re:In other news... by vegasmacguy · · Score: 1

      I did too, but when I didn't see one... I have to say I was disappointed. Somebody had to step up to the plate. :)

  33. Conclusions ? by thePig · · Score: 1, Interesting
    From the article
    Working out the protein's task won't be simple. With mice, researchers simply knock out genes to determine what they do. This cannot be done with primates.

    I do not understand. Even though the issue is with the multiple copies of the same gene, can't the researchers just knock off this single gene in mice and get the basic idea of what this protien is all about?

    After that they can go ahead and insert multiple copies to gather more info. But just because the protien is in the brain (and there are multiple copies in primates) doesnt alone to suggest that it is the one behind reasoning abilities of humans.

    One interesting fact is that it looks as if higher up the intelligence scale of primates, the higher the count seems to be.
    But is that enough? Cant it be something that can be related to any of the other defining characteristics of humans ?
    Say, opposible thumbs or bipedal motion or something? These also do have relation to brain, doesnt it?

    Anyways, it looks like there is much more to this than the article suggests, so I should keep mum, methinks
    --
    rajmohan_h@yahoo.com
    1. Re:Conclusions ? by lubricated · · Score: 1

      >> Can't the researchers just knock off this single gene in mice and get the basic idea of what this protien is all about?

      The researcher looking and analyzing this data, might not be the type of researcher that works with mice. Even if he was, he would probably get this paper our once this discovery was made. Another one after knocking the gene off.

      --
      It has been statistically shown that helmets increase the risk of head injury.
  34. There's a gene that confers some resistance... by exp(pi*sqrt(163)) · · Score: 5, Interesting
    ...to HIV. Chimps have more of them than humans. It seems likely that SIV (simian immunodeficiency virus) has existed in chimps much longer than HIV in humans. As a result, Chimps with more copies of the gene have outlived their less well endowed relatives and now almost all chimps can coexist with SIV without showing symptoms of immunodeficiency. Apparently humans have started making similar adaptations and in some areas of the world there is now a generation of humans who seem to do a fairly good job of coexisting with HIV. But all humans still have many fewer of these genes than chimps.

    But nobody would make the mistake of saying that this gene is the gene for 'chimpness'. It's just an accident of history that SIV arose before HIV.

    I learned all of this from an excellent podcast whose name I dare not write for fear of offence...

    --
    Doesn't it make you feel good to know that our freedoms are protected by politicans, lawyers and journalists.
    1. Re:There's a gene that confers some resistance... by geekoid · · Score: 1

      ummm...no

      There is a tiny group in europe that has a mutation of a cell recptor the makes them getting HIV/AIDS more difficult.

      Since it kills people after the time they can have had children, the people who are not naturally immune(if there are any) will still have their genes passed on. Basically the virus lives too long.

      It's one of the MANY many unique issus that makes this virus very tough to fight.

      --
      The Kruger Dunning explains most post on /. http://en.wikipedia.org/wiki/Dunning%E2%80%93Kruger_effect
    2. Re:There's a gene that confers some resistance... by Frank+T.+Lofaro+Jr. · · Score: 1

      It's just an accident of history that SIV arose before HIV.

      Perhaps HIV was created using SIV, thus arising later,

      --
      Just because it CAN be done, doesn't mean it should!
    3. Re:There's a gene that confers some resistance... by exp(pi*sqrt(163)) · · Score: 1
      There is a tiny group in europe that has a mutation of a cell recptor the makes them getting HIV/AIDS more difficult.
      I don't think this can be the same thing as what Steve Jones was discussing in the podcast. He was specifically interested in discussing the coevolution of humans and HIV and he gave the impression that the group of resistant humans wasn't all that small. It's a great podcast BTW.
      --
      Doesn't it make you feel good to know that our freedoms are protected by politicans, lawyers and journalists.
    4. Re:There's a gene that confers some resistance... by dkoulomzin · · Score: 1


      Many people are stricken with HIV or AIDS before they have children. Yes, they CAN breed, but many just don't on account of their disease. As far as evolution goes, same diff: fewer offspring from people without resistance.

      Also, if I understand the way HIV is passed, the offspring of people infected with HIV are at least somewhat more likely to have HIV. Children are unlikely to themselves have children unless they have some amount of resistance (either natural or artificial) to HIV; and in children the disease has longer to take its toll (or at least make itself known) before reproduction can begin.

      Bottom line: humans can/will acquire resistance to the disease. On the other hand, I'm pretty sure we shouldn't be waiting for humans to evolve in order to combat the disease. I'm just saying from an evolutionary perspective, it will happen or we'll die out.

      --
      Thou shalt not begin a subject line or post with the word "Umm".
    5. Re:There's a gene that confers some resistance... by bar-agent · · Score: 1

      There was an article in Discover magazine (http://www.discover.com/issues/sep-06/rd/uniquedi seases/) that discusses this.

      Basically the theory goes that, at one point, humans were getting their asses kicked by a plague of some kind. Some of us had a mutation where genes that rein in the immune system were knocked out. With their immune system turned up to 11, these guys survived the plague.

      The downside is that our immune systems are now turned up to 11, hence all the immune system diseases like HIV and asthma that we get, that other primates do not.

      --
      i'd hit it so hard, if you pulled me out you'd be the king of britain [bash.org]
    6. Re:There's a gene that confers some resistance... by exp(pi*sqrt(163)) · · Score: 1

      That sounds different again from the story I was discussing. Nonetheless, it's interesting stuff and it's a great example of how a gene can be human-specific while having little to do with 'humanity'.

      --
      Doesn't it make you feel good to know that our freedoms are protected by politicans, lawyers and journalists.
    7. Re:There's a gene that confers some resistance... by evilviper · · Score: 1
      Since it kills people after the time they can have had children, the people who are not naturally immune(if there are any) will still have their genes passed on. Basically the virus lives too long.

      An HIV-infected person can still breed, but they will die shortly thereafter. The person they breed with will have a much increased chance of catching and dying of the disease just a few years later.

      Their children will have a good chance of catching the disease, and almost certainly dying long before they can reproduce. And even if the children don't catch HIV, the fact that one or both of their parents has died while they are too young to fend for themselves, does give them a much lesser chance of surviving.

      So, natural selection can't take care of it as quickly as it could for other, faster-acting diseases, but it will eventually build herd immunity to it, so long as the population doesn't ALL die in the period of time before enough people develop an immunity.
      --
      Slashdot gets worse every day... Pipedot: News for nerds, without the corporate slant
    8. Re:There's a gene that confers some resistance... by Lord+Ender · · Score: 1

      The same mutation that gave some europeans immunity to the plague also blocks HIV. Don't you watch PBS? Bad geek!

      --
      A slashdotter who didn't build his own computer is like a Jedi who didn't build his own lightsaber.
  35. Welcome to every science headline... by PRMan · · Score: 1

    There are constant articles of this nature in the media, especially those concerning dinosaurs, primitive man, origins of the universe, etc.

    --
    Peter predicted that you would "deliberately forget" creation 2000 years ago...
  36. I hate science reporters by Luxifer · · Score: 5, Insightful

    from paragraph 2 of TFA:
    "Scientists don't know what the gene does."
        No, they know what the gene does, it codes for a protein. They don't know what this protein does.
        Then they say that the protein is expressed all over, including the brain, so that means it may be involved in brain function.
    For all they know it could be a structural protein, which is a better bet if it's expressed outside the brain.
        Somehow I doubt that a single gene is responsible for humanity.

        I try to be positive when I post, but what kind of morons do they have writing this stuff? And this is Nature magazine? How about some info on what sort of protein it is: Kinase? Carboxylase? Protease? How about some info on the expression levels instead of how many copies there are? There could be 1000 copies in our genome, but if the expression is low, it doesn't matter.
        Guess I'll have to RTFP, where P=Paper.

    1. Re:I hate science reporters by jeschust · · Score: 2, Informative

      TFP, for those of you who subscribe to Science or you college kids slashdotting in the library: http://www.sciencemag.org/cgi/content/full/313/579 1/1304

    2. Re:I hate science reporters by Anonymous Coward · · Score: 0

      Torrent anyone?

    3. Re:I hate science reporters by Anonymous Coward · · Score: 0

      OK, You definately have a point... a major one. Most science reporters haven't a clue about the science they report on. At least some of the tech/geek reporters have an idea what's going on.

      HOWEVER, I hate to be the one to tell you (well, no, not really), but all the bio-chems you mentioned (How about some info on what sort of protein it is: Kinase? Carboxylase? Protease?) are enzymes.

      *ase => enzyme; *ose => surgar

      So, protease is a class of enzymes that break down proteins just as lactase is used to break down the lactose surgar found in milk.

    4. Re:I hate science reporters by ozbird · · Score: 1

      Somehow I doubt that a single gene is responsible for humanity.

      No, but there's a gene for oversimplication...

    5. Re:I hate science reporters by mapkinase · · Score: 1

      It is multifunction gene coding multidomain protein: codes also exaggeration, greed and dishonesty. Some people suggest just to call it J-gene.

      --
      I do not believe in karma. "Funny"=-6. Do good and forbid evil. Yours, Oft-Offtopic Flamebaiting Troll.
    6. Re:I hate science reporters by mapkinase · · Score: 1

      I went off to Pubmed right after I saw the gene/protein name at a /. piece and found the OSA - original scientific article. Knowing a long standing rivalry between Nature and Science I had a few chuckles.

      --
      I do not believe in karma. "Funny"=-6. Do good and forbid evil. Yours, Oft-Offtopic Flamebaiting Troll.
    7. Re:I hate science reporters by mapkinase · · Score: 1
      Science magazine abstract says (no link in Pubmed yet)
      DUF1220 domains are highly expressed in brain regions associated with higher cognitive function, and in brain show neuron-specific expression preferentially in cell bodies and dendrites.
      Your comment about this domain having structural function might be true, but it still could have a relevance to the "humanity" difference between humans and other mammals.
      --
      I do not believe in karma. "Funny"=-6. Do good and forbid evil. Yours, Oft-Offtopic Flamebaiting Troll.
  37. This is science? by TheWoozle · · Score: 1, Insightful

    Since when does wild-ass guessing = science that is newsworthy?

    How about they do a *lot* more research and then get back to us when they have more than "we found that humans have more copies of a 'mystery gene' that codes for proteins in the brain than a monkey"?!

    --
    Insisting on "correct" English is like saying that there is only one, definitive recipe for chili.
    1. Re:This is science? by BigAssRat · · Score: 0

      Because this is S.W.A.G, not W.A.G. (Scientific Wild Ass Guessing)

  38. Great.... by TrebleJunkie · · Score: 4, Funny

    ...now somebody's going to shove this thing a couple hundred times into a monkey, and it'll be fucking Planet of the Apes for real.

    --

    Ed R.Zahurak

    You know, oblivion keeps looking better every day.

    1. Re:Great.... by geekoid · · Score: 1

      Sweet!//I mean Ook!

      --
      The Kruger Dunning explains most post on /. http://en.wikipedia.org/wiki/Dunning%E2%80%93Kruger_effect
    2. Re:Great.... by Anonymous Coward · · Score: 0

      ...now somebody's going to shove this thing a couple hundred times into a monkey, and it'll be fucking Planet of the Apes for real.

      Honestly! If your going to be twisted, at least post it anonymous!

    3. Re:Great.... by TheDreadSlashdotterD · · Score: 1

      At least I won't be the only primate able to speak and grow a sweater.

      --
      I have nothing to say.
    4. Re:Great.... by Zigurd · · Score: 1

      Nah... "No food, no shelter, no monkey butlers. This island is a death hole."

  39. %s/monkey/fish/g by Anonymous Coward · · Score: 0

    Killing and eating a fish/monkey/rat is murder. /sarcasm off

    1. Re:%s/monkey/fish/g by Solra+Bizna · · Score: 2, Funny
      Killing and eating a fish/monkey/rat is murder. /sarcasm off

      I think killing and eating a fishmonkeyrat is downright weird.</joke>

      -:sigma.SB

      --
      WARN
      THERE IS ANOTHER SYSTEM
    2. Re:%s/monkey/fish/g by Drooling+Iguana · · Score: 1

      The other green meat!

      --
      ... I'm addicted to placebos
    3. Re:%s/monkey/fish/g by gasgesgos · · Score: 1

      Joke about fishmonkeyrat all you want, but don't even think about joking about manbearpig. He's a totally serial threat to humanity...

  40. Mod parent up by Anonymous Coward · · Score: 0

    Please mod parent +1 funny.

  41. Translated for my fellow slashdotters by Anonymous Coward · · Score: 0
    Translated directly from summary:
    Humans carry 212 copies of DUF1220, whereas George W Bush has 37 copies, and Steve Ballmer has only 30 copies.

  42. Whats the opposite of DUF? by CrazyJim1 · · Score: 4, Funny

    If DUF makes us smart, FUD must make us stupid.

    1. Re:Whats the opposite of DUF? by constantnormal · · Score: 2, Funny

      Yes, in a second announcement later in the day, the "inhumanity gene", FUD9999 was discovered.

      It took longer to recognize as it was so much more prevalent than the DUF1220 gene.

      Apparently, the function of the FUD9999 gene is to convert the proteins that DUF1220 encodes into a complex mixture of steroids and alcohol.

    2. Re:Whats the opposite of DUF? by Anonymous Coward · · Score: 0

      FUD is the marketing gene.

  43. Sad... by HotBlackDessiato · · Score: 1

    ...that my first anticipatory reaction to this headline was wondering what the republican counter response would be.

    --
    "If you don't have eyes you shouldn't have wings" -- Carl Pilkington
  44. give me some duff :) by Intangion · · Score: 1

    DUF fills your Q zone with pure DUF goodness :)

  45. DNA is software. by mlwmohawk · · Score: 1

    The more I read about DNA the more I have come to think of it in terms of software. Specific genes may be individual instructions and or subroutines. The order in which genes occur probably has as much to do with the whole thing as the pieces of the DNA itself.

    That's what worries me about genetic experimentation, of course it is nessisary, but I think we don't quite fully understand it yet and our experiments are like a nube cracker changing code with a debugger. Hopefully, what they experiment on just dies, because, you know, you never really know!

    1. Re:DNA is software. by Alderin1 · · Score: 1

      I have to agree here, I mean the chances of a noob cracker accidentally creating a virus from his code changes are slim (if he didn't start with a virus code, that is), but with our level of understanding of DNA, we don't know the chances, and our changes are done WITH viruses in the first place. Very scary if you ask me.

      If I had the pull and we had the tech in place, there really should be only one place for genetic experimentation: orbit. It CAN'T end up in the ecosystem from there if something goes wrong. At least, not without a lot of other things going wrong, but at least those other things we have statistics on.

      I keep thinking 28 Days Later when they start talking about gene splicing and genetic research. Sure, they are careful, methodical, and try to cover every variable... but one missed variable, one screw loose, one never understood bug in the genetic program... yikes.
       

      --
      No conformist ever made history.
  46. DUF1220 == Duff Beer? by thewiz · · Score: 0

    I wonder if DUF1220 is actually a gene that makes humans crave beer?

    --
    If "disco" means "I learn" in Latin, does "discothèque" mean "I learn technology"?
    1. Re:DUF1220 == Duff Beer? by myowntrueself · · Score: 1

      Yeah its what being human all comes down to; a gene for appreciating beer.

      --
      In the free world the media isn't government run; the government is media run.
  47. Semantics, but... by VorpalEdge · · Score: 0

    Scientists don't know what the gene does. But they do know that humans have more copies of it than chimpanzees, monkeys, rats and mice. And they know that the gene makes a protein that is found in the human brain

    Guess you know what the gene does then.

    You may not know what the protein does, but you know what the gene does.

    Besides, just because humans have more of something doesn't mean it's what automatically causes the brain's "unique ability to think and reason." For all you know, the protein may have different effects between species. This whole article seems like attention-whoring to me.

    Come back when you know something useful, k?

  48. Genetic Testing by Hoi+Polloi · · Score: 1

    Unfortunately, future candidates for political office will be tested for this gene. Those bearing it will be disqualified from running.

    --
    It is by the juice of the coffee bean that thoughts acquire speed, the teeth acquire stains. The stains become a warning
    1. Re:Genetic Testing by R3d+M3rcury · · Score: 1

      I think market forces have accomplished this far more effectively than government regulation could.

  49. Multiple carbon copies? by Anonymous Coward · · Score: 0

    Shouldn't that be multiple NUCLEIC ACID copies?!?!?! OMG LORFL

  50. Gene therapy? by jfengel · · Score: 1

    The important thing is, now that we've found the gene, will be able able to find a cure?

  51. Re:Obligitory Monkey Joke by sugapablo · · Score: 3, Funny

    Obligatory Simpsons Joke:

    "DUFMan, human! OH yeah!"

  52. Let's Uplift the Three-Toed sloth! by StefanJ · · Score: 4, Funny

    Three-toed sloths are an obvious first candidate to become earth's second sapient species.

    They can be put to work installing Wi-Fi nodes and spy cameras on telephone poles.

    And if they decide to rebel against their human creators, it will be really easy to outrun them.

    1. Re:Let's Uplift the Three-Toed sloth! by Anonymous Coward · · Score: 0

      In theory, yes. They are not exactly known as productive animals.

    2. Re:Let's Uplift the Three-Toed sloth! by dino213b · · Score: 1

      That reminds me of the Perry Bible Fellowship.

      Volcano Snails

    3. Re:Let's Uplift the Three-Toed sloth! by Anonymous Coward · · Score: 0

      I once read that some (I think) Victorian-era French wag said monkies were as smart as humans but acted stupid to avoid being put to work..

  53. It's not my fault, IntelliAdmin started it... by JonTurner · · Score: 1

    http://www.youtube.com/watch?v=2fc-sUtX0Eg

    Warning. Consume all beverages before watching.

    1. Re:It's not my fault, IntelliAdmin started it... by ptbarnett · · Score: 1
      The pre-punch line is also featured in a song frequently played on Dr. Demento's syndicated radio show. The lyrics are reproduced here: Wet Dream. It's a series of puns about fish and other aquatic life.

      The joke is a bit different:

      My barracuda was in the shop
      So I was in a rented stingray
      And it was overheating

      So I pulled into a Shell Station
      They said I'd blown a seal
      I said, "Fix the damn thing and leave my private life out of it, OK pal?"

  54. so... by Anonymous Coward · · Score: 0

    chimps are only 17.5% human?

  55. [Cue Barney Gimble's lip-rippling belch] by The_REAL_DZA · · Score: 2, Funny

    Moe : [reading from the bar's copy of Nature] "...it says here, that humans wouldn't be human without something called 'DUF'. Huh!"
    Barney [raising mug] : "I'll vouch for that! {BBBbBbbbbllllaaaabbllbbllbbllbb!!}"

    --


    This space intentionally left (almost) blank.
    1. Re:[Cue Barney Gimble's lip-rippling belch] by Anonymous Coward · · Score: 0

      ok, that's even weaker.

  56. As I recall this is a flipped segment by WillAffleckUW · · Score: 2, Interesting

    which was puzzling at first, because it's literally flipped around from the chimp gene, and actually is similar to a dog segment. Turns out a lot of what we thought were different gene segments folded wrong and literally reassembled upside down (backwards).

    However, just remember that just because we may have found a segment doesn't mean we understand how it works. Sometimes, it's not just the genes it encodes, it's how it impacts other genes on other chromosomes, and how it misfolds or affects transcription errors.

    Every day we learn more and more, and understand less and less. But it's fascinating work, and is leading to greater understanding of what makes us tick - even though we are all different and the variation among us homo sapiens is greater than the difference between homo sapiens and a chimp. Sometimes, you may find you may have more genetically in common with someone from Borneo when you're from Germany than you do with another person from Germany.

    [note - if I'm wrong about the flip, my apologies, it's been a summer with few seminars - reading the papers is harder in some ways]

    --
    -- Tigger warning: This post may contain tiggers! --
    1. Re:As I recall this is a flipped segment by TheLink · · Score: 1

      "the variation among us homo sapiens is greater than the difference between homo sapiens and a chimp."

      If you're talking about genetically, I doubt that is correct.

      That said, I do believe there are significant genetic differences amongst the different race (breeds) of humans. Not as different as the various dog breeds of course.

      In many things (not all) the top 1% candidates make the difference, so those "tiny" differences count for a lot. However in other cases the average/median "expression" counts for more (kindness, honesty, loyalty etc).

      --
    2. Re:As I recall this is a flipped segment by WillAffleckUW · · Score: 1

      I meant the variation between a specific individual and another specific individual being greater than the variation of the whole versus the whole - except in certain areas.

      --
      -- Tigger warning: This post may contain tiggers! --
  57. The Noodly Appendage Did It... by hcob$ · · Score: 2, Funny

    CAN'T YOU ALL SEE??? This is the work of his noodly appendage! We should all marvel at this(and his) wonderous and miraculus feat(and feet)! Anyone saying otherise is just speaking blasphemy!!!

    --
    Cliff Claven
    K.E.G. Party Chairman
    Founding Leader of: Koncerned for Egalitarin Governance
  58. More Common Elsewhere by dorath · · Score: 5, Informative

    I sent a link of the Slashdot article to my brother, with the requisite Duff joke. He responded by saying that DUF1220 is more common in rabbits, elephants, and some other stuff than it is in humans.

    I for one welcome our new armadillo overlords.

    http://genome.ucsc.edu/cgi-bin/hgTracks?hgsid=7703 1393&hgt.out2=+3x+&position=chr1%3A142191957-14219 9015

  59. good to know by rice_burners_suck · · Score: 1

    Good to know that I'm almost as smart as a monkey.

  60. We're already there by JonTurner · · Score: 2, Funny

    >>Apparently the current thinking is that this gene is responsible for coding important areas of brain function.
    >Well, why don't they make some knockout mutants and then look at the brain function? It seems like the logical next step.

    Three words: Jerry Springer Show

  61. Re:Obligitory Monkey Joke by WillAffleckUW · · Score: 1

    Wow. Doubly offtopic. Once for the lame joke, and once because you're pimping your website.

    And it was a really lame joke he made.

    Hey, if anyone's on Facebook, feel free to join my Seminar Junkies group - I'm the guy in the cape.

    Remember, even if we have 220 segments and chimps have 37 segments, it doesn't mean we know what they do, or how they impact other gene-encoding regions - it's only recently we started figuring out most of the segments we thought were "noise" are actually responsible for encoding other genes, due to transcription and folding "errors" - yet which make us what we are.

    --
    -- Tigger warning: This post may contain tiggers! --
  62. Poor humans still believe they are the pinnacle... by viking2000 · · Score: 1

    Poor humans are still trying to confirm that they are the pinnacle of the universe.

    From believing they are in the center of god's creation, they have slowly, as their knowledge increased lost again and again. First they discovered that the earth was not the center of the universe, then that the sun was just a mediocre star in an average neighborhood in an average galaxy. Darwin taught them that they are just another leaf on the tree of life.

    Now they are still clinging to the hope that their brains are so superior. The genome projects for some species may be the final nail in the coffin, for again they are likely to face disappointment.

    Just get it: you are monkeys that can vocalize a little.

  63. bananas by Anonymous Coward · · Score: 0

    So if I grow a banana with 213 copies of this gene grafted in somewhere, then the banana will be superhuman?

    1. Re:bananas by exp(pi*sqrt(163)) · · Score: 1

      What kind of ignoramus are you? Of course it wouldn't. With just 213 genes it'd qualify as slightly-better-than-average-human. But with 424 genes - now you're talking!

      --
      Doesn't it make you feel good to know that our freedoms are protected by politicans, lawyers and journalists.
  64. Re:It's a common mistake but is there proof? by WillAffleckUW · · Score: 1

    In your defense, they're quite hard to tell apart once you've had a few Duffs. What look like slightly unshaven legs and sloping posture the night before reveal themselves fully in the morning after.

    Have you tested that theory experimentally and repeatedly? And who did the peer review on the research?

    --
    -- Tigger warning: This post may contain tiggers! --
  65. OK, So I'm in a Bad Mood by XLawyer · · Score: 3, Funny

    "Perhaps most revealingly, transgenic mice with this gene incorporated into their genomes have been found to habitually scratch patterns on the floors of their cages that strongly resemble engineering blueprints for a flamethrower."

    1. Re:OK, So I'm in a Bad Mood by CptNerd · · Score: 1
      "Perhaps most revealingly, transgenic mice with this gene incorporated into their genomes have been found to habitually scratch patterns on the floors of their cages that strongly resemble engineering blueprints for a flamethrower."
      Are they named "Pinky" and sound like Orson Welles?
      --
      By the taping of my glasses, something geeky this way passes
    2. Re:OK, So I'm in a Bad Mood by evilviper · · Score: 1
      Are they named "Pinky" and sound like Orson Welles?

      Yes. Always.
      --
      Slashdot gets worse every day... Pipedot: News for nerds, without the corporate slant
  66. Does this prove Intelligent Design is flawed? by WillAffleckUW · · Score: 2, Funny

    Because, if God was such a bad programmer he had to encode it 220 times, instead of making an efficient coding paradigm that used only say three segments for backup ... well ...

    Or does it mean chimps run Linux and only need 22 code segments to do what Humans (Windows) needs 220 code segments to get done?

    --
    -- Tigger warning: This post may contain tiggers! --
    1. Re:Does this prove Intelligent Design is flawed? by vp0ng · · Score: 1
      Or does it mean chimps run Linux and only need 22 code segments to do what Humans (Windows) needs 220 code segments to get done?


      If chimps=linux, that does not bode well for the argument of linux=productivity
      I'd rather be a human than a chimp any day if both are trying to perform the same task, even if it means human=windows

      --
      (Futurama) Fry: "My folks were always on me to groom myself and wear underpants. What am I, the pope?"
    2. Re:Does this prove Intelligent Design is flawed? by WillAffleckUW · · Score: 1

      Maybe chimps are using CP/M?

      Smaller kernel, still works.

      --
      -- Tigger warning: This post may contain tiggers! --
    3. Re:Does this prove Intelligent Design is flawed? by vp0ng · · Score: 1

      still works, yes, but how many chimps on typewriters do you need to write a book compared to a single human? Comparing linux to a chimp is definitely a derogitory remark.

      --
      (Futurama) Fry: "My folks were always on me to groom myself and wear underpants. What am I, the pope?"
  67. Re:They couldn't have come up with a better name.. by BlahMatt · · Score: 1

    Ah... that explains it. So they assign a name based on it's function once (and if) they figure out what it does?

    --
    To understand recursion, one must first understand recursion...
  68. D'oh! The Homer gene by Anonymous Coward · · Score: 0

    Now don't you wish you had used a better subject line?

  69. In other news... by vegasmacguy · · Score: 1

    The UN has asked the Iranian government for full access to search for George Bush's 28 missing copies of the DUF1220 Gene. ::ducks::

  70. Sensationalism by avirrey · · Score: 1

    Sensation... Sensation... Sensation... I am so freggin glad scientist, because of the obscure nature of the unknown, are more like lawyers in their verbiage
    "Such a protein could have helped to define what makes our brains human, the scientists say, although they caution that that has not yet been proven, and probably won't be until they know what it does."
    Truth be told these DUFs could be something or they can be nothing. Hell, it could even equal how tall we should average on some universal measureing scale. What!?... it's in the brain? Maybe it's the amount of unused space since we appear to get dumber and dumber with every passing generation. I'd be intrested in finding out if these DUFs are in fish or reptiles or birds. It could just simply be the expected amount of memory allocation... WEEEEEEE! A reference to man vs machine... it's our RAM +/- a few random fab defects. I love it when a scientist says "It could..." and the media says "There's a link!!"

    ~~ Correct my speeling and I'll kick your butt ~~

  71. Karma be damned... by SkyWalk423 · · Score: 1

    The natural follow-up study: Who has more DUF1220 on average, men or women?

    1. Re:Karma be damned... by Tyger · · Score: 1

      Unless it is encoded in the X or Y chromosome... Neither. If it appears in the Y chromosome, then men will, but only by a small bit, as the Y chromosome doesn't really encode much information anymore. If it's in the X chromosome, women will have more, but from my understanding it doesn't make a difference because one of the two Y chromosomes would not be active anyway. However, from a link someone else posted to the human genome project, it looks like it is not in the X or Y chromosomes.

  72. Explains George Bush by Master+of+Transhuman · · Score: 1


    He has only ten copies.

    The caption on the picture in the article says, "What makes humans, primates, unique?"

    Who says they're unique?

    --
    Richard Steven Hack - This sig is TOO GODDAMN SHORT TO DO ANYTHING USEFUL WITH! MORONS!
    1. Re:Explains George Bush by chris_eineke · · Score: 1

      Sorry, dude. Unique is part of the enumeration. So the question becomes: What makes unique?

      And the answer to that is Snowflakes. :P

      --
      "All you have to do is be fragile and grateful. So stay the underdog." Chuck Palahniuk, Choke
    2. Re:Explains George Bush by Master+of+Transhuman · · Score: 1


      Way to go, missing my point.

      --
      Richard Steven Hack - This sig is TOO GODDAMN SHORT TO DO ANYTHING USEFUL WITH! MORONS!
  73. Now. the big question is... by feepness · · Score: 1

    Can it be spliced into Dick Cheney with a retro-virus?

  74. Genetics and Human Memory by not-enough-info · · Score: 1

    The assumption that DNA exists solely to produce proteins is wrong. Current research suggests that DNA (via mRNA) has a direct role in memory formation in the brain. In fact, many genes have been identified whose role it is not to produce proteins, but serve as a mechanism in thought and memory formation and reinforcement. Considering that there may be many similar or identical functions in the brain with regards to thought and memory, intelligent organisms having multiple copies of these memory controlling genes is unsurprising.

    here's a related study for you:
    http://www.cell.com/content/article/abstract?uid=P IIS0092867405014042

    To draw a software analogy:
    Lets say the compiled binary + all configuration and data files of your program is DNA. There are parts of the of the program that define proteins and physical structures i.e. data files, string constants, etc. There are also parts that define the sequence of events from start to finish, growth, and change i.e. the instruction code that gets sent to the CPU for processing.

    For DNA that controls memory and thought formation, we can think of this as meta-code or configuration files. These files dictate what parts of the instruction code get loaded, linked, and run and under what circumstances. This meta-code may not actually perform computation or build useful data (no growth, no respiration, no protein production), but it defines how the program (organism) operates.

    e.g. One bit of code might load the appropriate vectorized FP library when there is hardware support. Or, biologically, one bit of DNA might make a person always remember technical information under normal circumstances.

    --
    ---k--
    </stupid>
  75. Wait a second by zerosix · · Score: 1

    Humans have 212 and chimps have 37???
    That can't be right...I could have sworn we were a close relative....

    --
    Only two things are infinite, the universe and human stupidity, and I'm not sure about the former. ~Albert Einstein
  76. but by Monsuco · · Score: 1

    Interesting, our brain is the way it is because of some DUF genes. Perhaps if one modified these genes enough, our brain could run lin... never mind.

  77. So... by ijakings · · Score: 0

    Giving people MORE of this can make them... fly objects around a room and self heal. Anubis don't look too smart now does he.

  78. In a related story.. by EugeneK · · Score: 0

    Scientist could find no sign of the gene in President Bush. The scientists admit that this could mean that, as widely suspected, Bush is actually a simian.

  79. Not as widely reported, but still interesting by g1zmo · · Score: 4, Funny

    Humans carry 212 copies of DUF1220, whereas chimps have 37 copies, and monkeys have only 30 copies.

    Corporate CEOs carry between 3-6 copies of the gene, and no one has yet to find a middle management specimen exhibiting even a single instance.

    In addition, a representative sample of Slashdot readers was tested and there was a remarkably strong correlation between their karma level and copies of the gene. Digg readers came in slightly above MySpace users with 10 and 4 copies, respectively. 8^)

    --
    I have found there are just two ways to go.
    It all comes down to livin' fast or dyin' slow.
    -REK, Jr.
    1. Re:Not as widely reported, but still interesting by IcyNeko · · Score: 1

      Peter! What's happening. Look, I'm going to need you to come in on Saturday to put TPS report covers on all these DUF1220 test samples, mmkay? I'll go ahead and make sure that you have a copy of the memo.

  80. Re:Obligitory Monkey Joke by coldtone · · Score: 1

    I was waiting for that one. :)

  81. No man, the DUF1220 gene codes for lawyers by Anonymous Coward · · Score: 0

    Those geneticists are interpreting their results through rose-tinted spectacles.

    The truth is somewhat more sordid.

  82. Re:They couldn't have come up with a better name.. by Anonymous Coward · · Score: 0

    Could be worse...could be Slurm....

  83. Oh the humanity!!! by erroneus · · Score: 2, Funny

    (do I really need to put anything else in here for that to be funny?)

  84. This sounds like... by wonkavader · · Score: 1

    ... a GUESS.

    And this is peer review? How many copies of this do their peers have?

  85. Re:They couldn't have come up with a better name.. by geobeck · · Score: 1

    I thought it was Draft* of Uncertain Fermentation...

    *or draught if you're from the other side of the pond.

    --
    Find environmentally and socially responsible products on http://buy-right.net
  86. Wow by johansalk · · Score: 1

    This whole genes talk is too common now to notice, but when you step back, and think about it, it really, really boggles the mind. All these creatures came from these little tiny strings playing with each other.

    1. Re:Wow by Cybert4 · · Score: 1

      Nah, it's not too interesting. Besides microscopic flagella, nature didn't even invent a wheel.

  87. So they don't lack by __aahlyu4518 · · Score: 1

    "It appears that humans have multiple carbon copies of a recently discovered gene that other primates lack. In particular, one sequence not so romantically or emotionally termed 'DUF1220' was mentioned . Humans carry 212 copies of DUF1220, whereas chimps have 37 copies, and monkeys have only 30 copies."

    So chimps have 37 copies, monkeys have 30. Apparently... these animals are not primates. Because the claim is that other primates lack this gene.
    If they ARE primates AND have copies of this gene... then... maybe it just makes us superprimates at best ?????

    1. Re:So they don't lack by stonecypher · · Score: 1

      then... maybe it just makes us superprimates at best ?????

      That you're only just now figuring that out suggests that perhaps you're not one of us at all.

      --
      StoneCypher is Full of BS
  88. Re:Poor humans still believe they are the pinnacle by l33t+gambler · · Score: 1
    Just get it: you are monkeys that can vocalize a little.
    Well, we have quite certainly evolved from monkeys, but we have certain unrivaled features. We have a huge butt-muscle that give us stability when we walk, which give balance and a possibility to travel far distances and adapt to agriculture, becoming farmers. That was probably what made food abundant and we could trade and form societies. Some say we would never reach our current state had it not been for some grand-father discovering alcohol and wanting more (crops left in a cup in the rain).

    Our hands are unique and makes it easier for us to use tools. When we started "beating" and cooking meat we didnt need so big muscle jaws and teeth so we got more room for bigger brain. Neanderthal didn't make it because they didnt have big enough ear-bones thus lacked the balance to run and throw a spear and couldn't survive when the wood shrank; they snoke upon animals among the trees and stabbing them with a spear.

    Our mind is structured so we are intelligent. Thinking about this I find it harder to belive in intelligent life other places in our galaxy, and the more important to take care of our earth http://jooh.no/ Religion and pseudoscience is boring it has nothing on science, long live science. Religious fanatic people are annoying and sometimes dangderous, but that is another discussion.
    --
    Teasing the nobles, and rightfully so!
  89. Re:It's a common mistake but is there proof? by RsG · · Score: 1
    Have you tested that theory experimentally?
    I assure you sir, there is no way to test this theory that is not "experimental" :-)
    --
    Erotic is when you use a feather. Exotic is when you use the whole chicken.
  90. DUF stands for "Domain of Unknown Function" by dokebi · · Score: 3, Informative

    The Abstract of paper:

    Extreme gene duplication is a major source of evolutionary novelty. A genome-wide survey of gene copy number variation among human and great ape lineages revealed that the most striking human lineage-specific amplification was due to an unknown gene, MGC8902, which is predicted to encode multiple copies of a protein domain of unknown function (DUF1220). Sequences encoding these domains are virtually all primate-specific, show signs of positive selection, and are increasingly amplified generally as a function of a species' evolutionary proximity to humans, where the greatest number of copies (212) is found. DUF1220 domains are highly expressed in brain regions associated with higher cognitive function, and in brain show neuron-specific expression preferentially in cell bodies and dendrites.

    --
    In Soviet Russia, articles before post read *you*!
  91. Re:Poor humans still believe they are the pinnacle by viking2000 · · Score: 1

    ..Well, we have quite certainly evolved from monkeys..

    Are you sure you are using an impartial yardstick here? Imagine you are reading the history books a billion years from now.

    Maybe the monkeys have a lot more sex, and are much more happy. They do not destroy the earth either.

    Humans may be on a path to:
    1. Create silicon based life that will evolve much fater than humans
    2. Destroy and exhaust much of the earth resources.

    This may not be very much more advanced than yeast in a vat of wine hurrying to extinction.

  92. Re:They couldn't have come up with a better name.. by chris_mahan · · Score: 2, Funny

    Completely offtopic but there it goes:

    It's Draft on the western side of the Atlantic because we're still trying to perfect the brews.

    --

    "Piter, too, is dead."

  93. The secret of NIMH by SnarfQuest · · Score: 1

    Now we know what the secret of NIMH was.

    http://www.imdb.com/title/tt0084649/

    --
    Who would win this election: Andrew Weiner vs Andrew Weiner's weiner.
  94. Tell me when they isolate the "stupid driver" gene by plasmacutter · · Score: 1

    Blah.. who cares.. we can't get to work weeding out the morons until we find genese of substance whose carriers we need to exterminate. first target... the gene which causes idiots to pull to a stop and gawk at accidents on highways with a 40mph min speed limit.

    --
    VLC FOR MAC IS DYING! IF YOU DEVELOP, PLEASE SAVE IT!!
  95. Re:They couldn't have come up with a better name.. by bar-agent · · Score: 1

    There are lots of DUFs.

    Yup, there sure are! I usually sit on mine.

    --
    i'd hit it so hard, if you pulled me out you'd be the king of britain [bash.org]
  96. Re:They couldn't have come up with a better name.. by TCQuad · · Score: 1

    Keyword : Domain. Domains are subsequences within proteins. Conserved domains are named based on function, the original protein it was found in or a description of the overall structure structure and they typically have a similar shape and/or activity.

    Therefore, Simpsons jokes aside, this isn't a protein named DUF1220, but rather a protein called MGC8902 that contains DUF1220 domains.

  97. Re:They couldn't have come up with a better name.. by ClamIAm · · Score: 1

    And to make the circle complete, "Domain of Unknown Function" sounds a lot like the brains of people who drink Duff. Or something. But I totally agree there are a lot of them.

  98. Re:Poor humans still believe they are the pinnacle by Anonymous Coward · · Score: 0

    "The genome projects for some species may be the final nail in the coffin, for again they are likely to face disappointment."

    Tell me, which species is carrying out these 'genome projects'? They must be quite clever and resourceful.

  99. It's misspelt by XB-70 · · Score: 1

    There's a slight typo: DUFF1220 decoded à la Homer Simpson: Duff = Beer - translation: "Mmmmmmmm, Beer! Good." - QED: Proof of humanity. 1220 is the expiry date: Dec. 20th.

    --
    *** Don't be dull.***
  100. Added footnote by dr7greenthumb · · Score: 1

    Bottom line: humans can/will acquire resistance to the disease.

    The last estimate I read was that humans would acquire resistance after about 40 more generations.

  101. My New License Plate by DaftShadow · · Score: 1

    7 characters. pwned.

  102. More like DFU than DUF by Anonymous Coward · · Score: 0

    With how we treat eachother on this single planet of ours its more like we all carry the Dumb Fucking User gene rather than DUF gene......

  103. mod the gene redundant by metroplex · · Score: 1

    Mod the gene -1 redundant.

    --
    "Words of wisdom: drop that zero and get with the hero" -- Vanilla Ice
  104. There would be *NO* humans! by mangu · · Score: 1

    If RIAA were in command, everyone would have only the one copy they paid to use. Note that I didn't say "own", because RIAA would be the owner of all the copies, you would pay to get a user license.

  105. Causation by mangu · · Score: 1
    I really wish people would stop invoking "correlation does not imply causation" as a mantra.


    Me too. What this sentence "correlation does not imply causation" really means is that we may not be really sure of which is cause and which is effect.


    In this particular cause, the direction from cause to effect is *VERY* clear to me: the presence of genes is the cause of whatever effect we are observing. If we have a characteristic, being human, correlated with the presence of one particular gene, I consider it absurd to suppose that being human could be the cause of that gene existing in us.


    It might not be the *only* cause, but if that gene exists in statistically significant numbers depending on the relative degree of likeness to humans, then it's certainly one of the causes that make us human.

  106. Binky and the Brain by SoopahMan · · Score: 1

    Given researchers' habit of experimenting on mice, is it only a matter of time before this gene is inserted into 2 baby mice, and one asks the other, "What we gonna do tonight Brain?" If so, we might not like the other's answer.

  107. Gene Cafe by 8ball629 · · Score: 1

    You know this scenario will happen one day ;)...

    Waitress: Can I take your order?
    Gentleman: Yes. I'd like 230 DUF1220s, a bagel and a small orange juice this morning.

  108. DUFF!!! by Anonymous Coward · · Score: 0

    I knew beer had something to do with it! :)

  109. Backups are important! by Hugues999 · · Score: 1

    Those foolish monkeys don't realize how important having multiple backups is! 30 just isn't enough for us mighty humans.

  110. Aside from the obligator Simpson statements... by Assassin+bug · · Score: 1

    This is actually a really big deal. There are a lot of genes out there in many organisms that have these really long nucleotide repeats in them just like this one. They are very very very difficult to sequence. The researchers deserve at least a pat on the back for this one.

    On an another somewhat related note -- If there truly is one gene that is making us more human than a Bonobo chimp then, the next logical step is... Take this nifty gene and splice it into a chimp genome (easier said than done I'm sure, it's a lot easier with viruses) and see what you get.

    So, if that were possible and a humanoid resulted, wouldn't that be interesting. What would Michael Behe say about Darwin's so called "black box" then!? LOL

    A more less related thought... How much of the anti-evolution rhetoric is going to push science further and sooner into revealing what the anti-evolution crowd doesn't what to know?

  111. no such thing as a humanity gene by mrpeebles · · Score: 2, Insightful

    There is more to being human than genes and flesh. A baby is raised without human contact may grow up to be a human being, but certainly not a functional human being. And homo sapiens existed for tens, or hundreds, of thousands of years before acquiring religion, language, art, etc., aspects of civilization we consider important parts of our humanity. Isn't the most we could ever find a gene that allows us to be human? To make an analogy, ink allowed the original manuscript of Hamlet to be Hamlet, but it's not a Hamlet material. It doesn't contain the essence of Hamlet-ness in any meaningful sense.

  112. Re:The Noodly Appendage Did It... by Ogman · · Score: 1

    All Hail the Great FSM!

    --
    But Officer, I DID read the f**king article!
  113. One step better than meatspin by Anonymous Coward · · Score: 0

    So if we splice 200 copies into that of a member of congress, they will become human? Crazy!

    Step 1: Splice genes
    Step 2: ????
    Step 3: Profit!!!

  114. Re:They couldn't have come up with a better name.. by hotdiggitydawg · · Score: 1

    Nice :)

    Just as offtopic, but for those of us who don't really know what the term draught really means in a beer context...

  115. Spanner in the works by Anonymous Coward · · Score: 1, Insightful

    Sorry to throw the proverbial at the fan here, but how long before lobby groups have major objections to this kind of research? I'm not just talking about the religious right here, it includes the politically-correct left as well. We are supposed to believe in a world of harmony, tolerance, multiculturalism and equality, with any hint of the difference between human races being taboo. Anyone questioning the status quo risks being defamed, losing their job, spied on, and perhaps even sued, fined or imprisoned. Most of us have probably been taught at high school there is less genetic diffence between (for example) a white northern European and a black sub-Saharan African than there is between two white northern Europeans. Yet when one watches the olympics, it seems obvious there are real, fundamental biological differences betweem races.

    Religious groups have previously tried to censor research and punish scientists who published views that would question their power. Fossil fuel lobbies tried to censor research into global warming, the environmental movement tried to stop research into nuclear power, and cigarette companies covered up research relating to smoking and health. Likewise, research into what makes us human and how we evolved could expose the mechanisms that make human races different. This is something that liberal and multicultural elites will not allow, even in the face of conclusive evidence.

  116. Whoa by argStyopa · · Score: 1

    So "Duf" makes us smart?

    As Duffman would say (Obligatory Simpsons quote): "Oh yeah!"

    --
    -Styopa
  117. I doubt they code for brain function... by divisionbyzero · · Score: 1

    Everyone is so focused on our big brains that I think it'll probably end up obscure something more fundamental. I am not saying that we aren't different because of our brain size, but I think it'll be something indirect that allows us to have such a big brain. There are some obvious ones like cranium size, but I'm thinking something at the immune system level.

  118. Domain of Unknown Function? by Jesus_666 · · Score: 1

    Damn those domain squatters!

    --
    USE HOT GRITS WITH STATUE OF NATALIE PORTMAN (NAKED AND PETRIFIED)
  119. Re:They couldn't have come up with a better name.. by mapkinase · · Score: 1

    Unfortunately, it is a name technically... And those "hypothetical", "putative" rush in to the databases by hordes.

    Being only distantly familiar with Pfam I have never seen DUFs in it before. I have to admit that have not touched Pfam since 2001.

    --
    I do not believe in karma. "Funny"=-6. Do good and forbid evil. Yours, Oft-Offtopic Flamebaiting Troll.
  120. Planet of the Apes? by Anonymous Coward · · Score: 0

    Now we can genetically engineer those smart monkeys, chimps, etc. from Planet of the Apes...

  121. Brain wrinkling side effect by Randym · · Score: 1
    If this gene leads to over-expression of dendrites, it could, as a side effect, lead to the accidental linkage of parts of the brain that don't normally "touch". For example, some cases of synthesia might be explained in this way. Crinkling of the brain in Wernicke's area could lead to the development and expression of novel metaphorical images. Over-expression of dendrites could lead as well to a generalized explosion of cranial capacity, as the brain attempts to make room for all the new dendrital connections. Associative awareness in particular would benefit; the neural networks that make up our brains would "focus" faster.

    Unique combinations of abilities arising in this way could lead to selective breeding adavantages and thus be conserved in the population.

    --
    DNA is a Turing machine. You, however, being dynamic and emergent, are not.
  122. Re:failz08s by Anonymous Coward · · Score: 0

    Sorry about that, had the adaptive word engine open and the cat walked on the keyboard.

          - parent poster