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Tainted Pills Hit US Mainland

Tech.Luver notes an AP story on tainted pills that have arrived in the US from — not China this time — Puerto Rico. The article details a disturbing number of incidents of contamination investigated by the FDA over the last few years. "The first warning sign came when a sharp-eyed worker sorting pills noticed that the odd blue flecks dotting the finished drug capsules matched the paint on the factory doors. After the flecks were spotted again on the capsules, a blood-pressure medication called Diltiazem, the plant began placing covers over drugs in carts in its manufacturing areas. But the factory owner, Canadian drug maker Biovail Corp., never tried to find out whether past shipments of the drug were contaminated — or prevent future contamination, according to US regulators... FDA officials say the problems in Puerto Rico are proportionate with the large number of pharmaceutical plants here and generally no worse than those on the US mainland."

162 comments

  1. More like Bioveil... by phatvw · · Score: 1

    More like Bioveil...

    1. Re:More like Bioveil... by FesterDaFelcher · · Score: 1

      How about BioEvil?

      --
      My user number is prime. Is yours?
    2. Re:More like Bioveil... by Anonymous Coward · · Score: 0

      The author of this article should have done a little bit more of research. If you look at the island that is 100x50 miles, the FDA agency has more presence on it relative to the 50 states. The agency is typically every year in pharma. They are also more strict than the states. There are very few companies that are 30 years old as he states. I don't know were he gets his information from, but definetely he should come down to the island and talk to a few folks that are in the industry as well before making some pathetic comments. Nick.

  2. Article Mentions Problems in U.S. Also by eldavojohn · · Score: 4, Insightful
    Ok, so let's keep ripping on those foreign drugs even though the article mentions several times that this is also a problem on the mainland. It mentions several times that Puerto Rico is the epicenter of drug plants, shouldn't it have a higher number of incidences? Do they even do a ratio of incidences to plant comparisons. Honestly, they're under FDA inspection, just like all the U.S. plants.

    Tainted Pills Hit US Mainland How about a title more like "Tainted Foreign Pills Meet Tainted Pill Level Requirements on Mainland." What's the matter? Not quite as hard hitting and blood boiling at those damned cheap non-U.S. labor supporting foreign pills killing somebody?

    So you know, considering that most paint today is safe enough to use as a food coloring, in sunscreen or even toothpaste, I would prefer my elderly grandma consume the paint flecks accidentally with her medication instead of not being able to afford the medication.

    So where's the story here? These paint flecks kill somebody? You want the FDA to get anal retentive on your medications, fine. Just realize those expensive drugs are going to get a little more expensive and sick people who are poor might not be able to afford them anymore.

    Honestly I've heard of worse things being found in food than this.
    --
    My work here is dung.
    1. Re:Article Mentions Problems in U.S. Also by dj.delorie · · Score: 4, Informative

      Puerto Rico is part of the USA. It's not foreign drugs they're talking about, its *domestic* drugs.

    2. Re:Article Mentions Problems in U.S. Also by moderatorrater · · Score: 1

      You do realize that Puerto Rico is part of the US, right? That's why they say "mainland" and don't say "foreign" in the summary. What this really shows is that factories everywhere can fuck up.

    3. Re:Article Mentions Problems in U.S. Also by Anonymous Coward · · Score: 1, Interesting

      You want the FDA to get anal retentive on your medications, fine

      That's the thing. When you look, you find stuff that may or may not be relevant or a problem: take the foam issues with the shuttle. Who knows if all of the insulation issues are actually threatening or not, they didn't start looking until after the last one blew up, so there's no way of knowing if the foam always cracked up or not.

      The alternative is not looking at all, and I'd trust the drug companies even less in that situation.

    4. Re:Article Mentions Problems in U.S. Also by Anonymous Coward · · Score: 3, Informative

      Puerto Rico is part of the USA. RTFA, the article said the company selling the drugs is Canadian:

      But the factory owner, Canadian drug maker Biovail Corp... Sounds like those foreign drugs everyone is crossing the border to purchase.
    5. Re:Article Mentions Problems in U.S. Also by Red+Flayer · · Score: 0, Flamebait
      Nice troll.

      Not sure if your error was intentional, but I bet it was... sure to get a lot of responses.

      You want the FDA to get anal retentive on your medications, fine. Just realize those expensive drugs are going to get a little more expensive and sick people who are poor might not be able to afford them anymore.
      That's horsepoop. Manufacturing costs of prescription medications are a small fraction of the total cost, except for orphan drugs with low usage. High-volume drugs, such as the ones mentioned in TFA, have an extremely small unit cost in relation to market price. R&D, marketing, even admin overhead dwarf manufacturing costs.

      Another fine post from EDJ. Full of inaccuracies, conjecture, and trite sentences devoid of real meaning.

      /Disgusted with myself for feeding the troll.
      --
      "Trolls they were, but filled with the evil will of their master: a fell race..." -- J.R.R. Tolkien on Olog-hai
    6. Re:Article Mentions Problems in U.S. Also by Jeff+DeMaagd · · Score: 4, Interesting

      You're missing a significant issue. If paint flecks can get in, what else is getting in there? Why would you have any confidence in the quality of the pills if they can't be bothered to actually control what actually gets in there?

      I for one don't think it's expensive on a per-pill basis to keep a plant like that clean, they should have been clean in the first place.

    7. Re:Article Mentions Problems in U.S. Also by TubeSteak · · Score: 3, Interesting

      You want the FDA to get anal retentive on your medications, fine. Just realize those expensive drugs are going to get a little more expensive and sick people who are poor might not be able to afford them anymore. I'd love it for the FDA to get anal retentive about inspection regimes.

      If you knew anything about the pharma industry, most of those expensive drugs cost next to nothing to manufacture. The sick and poor can usually get subsidised/free drugs through pharma company programs.

      The high retail price of drugs bears almost no relation to its cost, partially because the drug industry spends more on advertising than R&D, but mostly because the market will bear it.

      I can't really think of anything other than vaccines that pharma companies sell without a crazy profit margin. Can you?
      --
      [Fuck Beta]
      o0t!
    8. Re:Article Mentions Problems in U.S. Also by BloodAngel_Au · · Score: 5, Informative

      Interesting Fact
      The term "United States" when used in a geographical sense on official documents, acts and/or laws; includes the Commonwealth of Puerto Rico, the Virgin Islands, Guam, and American Samoa.

      The U.S. has twelve unincorporated territories, also known as possessions, and two commonwealths. The major possessions are American Samoa, Guam, and the U.S. Virgin Islands. All of these have a non-voting representative in the U.S. Congress. The major commonwealths are Puerto Rico and the Northern Marianas. Commonwealths have their own constitutions and greater autonomy than possessions, and Guam is currently in the process of moving from the status of unincorporated territory to commonwealth. The residents of all of these places are full U.S. citizens, with the exception of those on American Samoa who are U.S. nationals, but not citizens.

      U.S. Commonwealths/Territories include: American Samao (AS), Baker Island*, Howland Island*, Guam (GU), Jarvis Island*, Johnston Atoll*, Kingman Reef*, Midway Islands, Navassa Island*, Northern Mariana Islands (MP), Palau (PW), Palmyra Atoll*, Puerto Rico (PR), U.S. Virgin Islands (St. Croix, St. John and St. Thomas) (VI), and Wake Island*.

      Puerto Rico has its own Olympic team and competes in the Miss Universe pageant as an independent nation.

      * Uninhabited

      quoted from http://welcome.topuertorico.org/government.shtml

      So, you have it correct dj. I'm sure this will suprise a few people, considering when most mention USA, they think of the mainland, hawaii & alaska. I know I did.

    9. Re:Article Mentions Problems in U.S. Also by angryfirelord · · Score: 1

      You want the FDA to get anal retentive on your medications, fine. Just realize those expensive drugs are going to get a little more expensive and sick people who are poor might not be able to afford them anymore. Why wouldn't you want the FDA to be anal retentive? Heck, that's their job, to make sure the food and medication I take won't kill me!
      http://en.wikipedia.org/wiki/FDA

      The Food and Drug Administration (FDA) is an agency of the United States Department of Health and Human Services and is responsible for the safety regulation of most types of foods, dietary supplements, drugs, vaccines, biological medical products, blood products, medical devices, radiation-emitting devices, veterinary products, and cosmetics. So as you can see, the FDA has a pretty huge task and anything less then anal could potentially kill more people than those who couldn't afford it. Personally, I feel the drug companies shouldn't be allowed to advertise. (who actually goes to their doctor and specifically asks for Lipitor?) Perhaps that extra cash could be used to make the drugs a little more cheaper.
    10. Re:Article Mentions Problems in U.S. Also by Anonymous Coward · · Score: 0

      Not true. Big Pharma spends on average 16-18% of sales on R&D--R&D in Pharma is unbelievably expensive due to all of the misses firms have. Only like 40% of compounds that make it to phase 3 trials, make it to retail. Additionally, we're in Puerto Rico, because the government there allows us to pay next to nothing in taxes for product we make there. And it is a tricky environment to manufacture in, given the language barrier, and availability of qualified help on the island.

    11. Re:Article Mentions Problems in U.S. Also by Froster · · Score: 2, Insightful

      Not quite. It takes a great deal of effort to sell drugs in the US market, and part of that is either FDA supervision of a Canadian or other foreign plant, or to make the drugs under US jurisdiction. In the case of Biovail, they chose the latter option. They chose that to be able to sell those drugs in the US. Otherwise, they could continue to produce drugs in Canada as they otherwise would have.

    12. Re:Article Mentions Problems in U.S. Also by Anonymous Coward · · Score: 0

      Yes!

      Because everyone knows that in Puerto Rico all the paint is made with Polonium with a hint of nuclear waste for flavor.

      Taking any pills that cost less than full USA retail will KILL YOU! Dont you know that! OMG! OMG! OMG!

    13. Re:Article Mentions Problems in U.S. Also by Spokehedz · · Score: 0

      PR is not part of the USA. It is a territory that the US owns.

      It is not a state. Therefore, it not part of the United States of America. That is why they said 'mainland' because that is what the USA is to PR.

      If you are going to be a prick, at least be correct about it.

    14. Re:Article Mentions Problems in U.S. Also by sumdumass · · Score: 1

      Well, sort of. The tests done on the foam initially was when the manufacturing process made use of some CFCs. The process had been changed but the foam was supposedly certified to be the same quality so there weren't any more extensive tests other then to see the differences in the properties.

      Last I heard, it turns out that there is a small difference in the cohesion which causes the new style of foam to fall in larger chunks with more of a cascade effect then the original versions. Evidently, while the foam retain most of the characteristics of the old version, it was actually structurally stronger in the center of the foam where closed cells containing pockets of air would be subjected to changes in pressure and temperatures. Supposedly, this meant that it was more rigid inside the structure of the foam and instead of popcorning with small piece flacking off, it would create a tear that would grow until enough force pulled large pieces off.

      What this really means if that it was looked at and determined that the falling foam wouldn't present a problem but after the changes, the chunks got bigger and became a problem that was first noticed with an explosion that killed the crew and lost the shuttle. So it wasn't that they didn't start looking until one blew up, it was that they looked and determined it not to be a problem until one blew up. Unfortunately the CFC creation process is still in use and was used on portions of the shuttle but isn't being brought back into use large scale in the near future. But it wouldn't really matter because they look at the falling foam in a different light now anyways. It wouldn't solve or negate any of the added precautions in place today.

      I have read reports that say the Foams cohesion wasn't the problem and I have read reports where it was and that the conversion from freon to non freon didn't make a difference. Most of those reports hinge around environmental activism so you have to take them all with a grain of salt.

    15. Re:Article Mentions Problems in U.S. Also by TubeSteak · · Score: 2, Informative

      Not true. Big Pharma spends on average 16-18% of sales on R&D In what years?
      http://www.sciencedaily.com/releases/2008/01/080105140107.htm
      "The researchers' estimate is based on the systematic collection of data directly from the industry and doctors during 2004, which shows the U.S. pharmaceutical industry spent 24.4% of the sales dollar on promotion, versus 13.4% for research and development, as a percentage of US domestic sales of US$235.4 billion."

      Assume those percentages are off by an enormous 10% margin of error... advertising still outstrips R&D.
      A quick trip to Google shows that spending rose in 2005, 2006 and 2007.

      Note: that study only looks at domestic sales & advertising, which means it doesn't show us the full picture. R&D would be even less as a percentage of global sales.

      --R&D in Pharma is unbelievably expensive due to all of the misses firms have. Only like 40% of compounds that make it to phase 3 trials, make it to retail. I can't speak to the truth of your 40% figure, but even if that is true, it is irrelevant at best. Pharmas are making money hand over fist even after you subtract their operating expenses from the >50% of their sales revenue that doesn't go to R&D and advertising.

      Anyone capable of basic math can easily put the lie to your assertions.
      --
      [Fuck Beta]
      o0t!
    16. Re:Article Mentions Problems in U.S. Also by hjf · · Score: 1

      shit, at least TRY not to sound so obvious, man! yes -- we know you cowboys don't like people like me, who talk foreign languages, especially that scum of a language, Spanish (my language, btw), the language of wetback, siesta-sleeping, lazy ass latins. but well, if you feel that way, why don't you write to your congressman and ask for Puerto Rico to be "freed" from the united states? maybe you could invade some other island with blonde people with blue eyes. maybe they even speak english, have serial murderers and everyone is fat and ugly.

      fucking racist cunt.

    17. Re:Article Mentions Problems in U.S. Also by gEvil+(beta) · · Score: 1

      I guess using your logic neither Alaska nor Hawaii are part of the United States of America.

      Here's a hint: If you're going to tell other people to be correct about something, you'd better be damn sure you yourself know what you are talking about. And it's very clear here that you don't. Fucking dipshit.

      --
      This guy's the limit!
    18. Re:Article Mentions Problems in U.S. Also by Spokehedz · · Score: 1

      No. Alaska and Hawaii both have stars on the flag. Or did you miss that in your haste to try and correct me?

      Both AK and HI are states in the USA. Even though they are not attached to the mainland, they are still part of the USA because they are a state.

    19. Re:Article Mentions Problems in U.S. Also by Spokehedz · · Score: 1

      I have no problem with PR at all, whatsoever. It wasn't a personal dig at the territory nor the people in it. I was simply pointing out that it isn't a state but a territory as the parent post indicated it was. Which is why they used mainland, even though the USA owns PR.

      As another poster attempted to prove me wrong, AK and HI are also not part of the 'mainland' but they are indeed states.

    20. Re:Article Mentions Problems in U.S. Also by Reziac · · Score: 1

      "I can't really think of anything other than vaccines that pharma companies sell without a crazy profit margin."

      Erm... new vaccines have the same crazy profit margin as any other drug that's still under patent. I've seen newly-developed animal vaccines retail for as much as $60 PER DOSE. Ask any horse person how much they had to cough up for West Nile vaccine the past few years, you'll get an earful.

      --
      ~REZ~ #43301. Who'd fake being me anyway?
    21. Re:Article Mentions Problems in U.S. Also by servognome · · Score: 1

      The high retail price of drugs bears almost no relation to its cost, partially because the drug industry spends more on advertising than R&D, but mostly because the market will bear it.
      Advertising has little relation to the cost of drugs. Advertising is used for drugs that are competitive, for example $250M spent on Tylenol. The high priced drugs are those where there is no effective alternative, so no advertising is necessary.
      So yes, R&D does have a relation on the cost of medicines, because the higher priced ones are those which a company has been able to develop and no one else has developed a competitive alternative.
      --
      D6 63 0D 70 89 81 BB 8E 7B 7C 5F 5D 54 EA AB 73
    22. Re:Article Mentions Problems in U.S. Also by servognome · · Score: 1

      Personally, I feel the drug companies shouldn't be allowed to advertise. (who actually goes to their doctor and specifically asks for Lipitor?) Perhaps that extra cash could be used to make the drugs a little more cheaper.
      It won't make drugs cheaper, because most of the advertisement goes towards medication that are competitive. It's cold, pain, and sex medicine that's being advertised, not the really expensive cancer treatments. Advertising does help let the patient become more informed about what is out there, do their own research, and make informed decisions about their treatment. So no you don't go to the doctor and say "I want Lipitor," but you can do your research and tell them you're worried about the side effect of drug A, and would drug B be a viable alternative.
      --
      D6 63 0D 70 89 81 BB 8E 7B 7C 5F 5D 54 EA AB 73
    23. Re:Article Mentions Problems in U.S. Also by Anonymous Coward · · Score: 0

      'Scuse me, but pills manufactured in Puerto Rico aren't, by definition "foreign," but DOMESTIC. Puerto Rico is a self-goiverning commonwealth under the jurisdiction of the United States - a technical part of the United States, but not one having statehood, like Guam and the U.S. Virgin Islands and FULLY under U.S. federal jurisdiction.

      The pills, de facto AND de juris, are NOT "foreign manufacture," but the company that OWNS the plant that manufactures them IS.

      A fine distinction, but a very critical one.

    24. Re:Article Mentions Problems in U.S. Also by DerekLyons · · Score: 1

      So you know, considering that most paint today is safe enough to use as a food coloring, in sunscreen or even toothpaste

      Um, no. One ingredient used as a pigment is also used for those purposes - nothing is said in the linked article about all the other ingredients used in paints.
       
       

      So where's the story here? These paint flecks kill somebody? You want the FDA to get anal retentive on your medications, fine. Just realize those expensive drugs are going to get a little more expensive and sick people who are poor might not be able to afford them anymore.

      Good. That's the FDA's whole job.
    25. Re:Article Mentions Problems in U.S. Also by cyberzephyr · · Score: 1
      Question. The pills did not come from the U.S., but they came from us?

      I better check my blood pressure medicine for paint or something else.

      --
      I'm here for the experience, not the Hyperbole.
    26. Re:Article Mentions Problems in U.S. Also by RexRhino · · Score: 1

      "The researchers' estimate is based on the systematic collection of data directly from the industry and doctors during 2004, which shows the U.S. pharmaceutical industry spent 24.4% of the sales dollar on promotion, versus 13.4% for research and development, as a percentage of US domestic sales of US$235.4 billion."

      Assume those percentages are off by an enormous 10% margin of error... advertising still outstrips R&D.
      A quick trip to Google shows that spending rose in 2005, 2006 and 2007. Except that "advertising" != "promotion".

      Advertising is a much smaller subset of promotion. Promotion means things such as providing training in the use of drugs for doctors and nurses, distributing free samples of the drugs, having highly trained professionals on call to answer technical questions a doctor might have about a new drug. This type of promotion is pretty much a nessicary part of selling a drug, and even if we had an entirely socialist model of drug development a lot of these costs would still exist (we just wouldn't call it "promotion").

      In 2004, about $265 billion was spend on advertising. Not too much different than U.S. drug sales in 2004. Since drug ads make such a small percentage of advertising compared to other products, it is very clear only a small chunk of "promotion" is spend on TV commercials, print ads, and the types of frivilous things people think of as "advertising".

      Anyone capable of basic math can easily put the lie to your assertions. You do the math... there is no way that the drug industry is spending $58 billion a year on advertising. No way! Trying to imply that drug conpanies spend a quarter of their profits on advertising is very silly.
    27. Re:Article Mentions Problems in U.S. Also by Burning+Plastic · · Score: 1

      Palmyra Atoll isn't actually uninhabited - it has researchers there all of the time and a few people who live there full time...

      --
      [All Your Fish Are Belong To Us]
    28. Re:Article Mentions Problems in U.S. Also by KDR_11k · · Score: 1

      Advertising allows you to make informed decisions? I thought the whole point of advertising is to prevent those.

      --
      Justice is the sheep getting arrested while an impartial judge declares the vote void.
    29. Re:Article Mentions Problems in U.S. Also by palegray.net · · Score: 2, Funny

      Wait... foreign companies, producing drugs at American facilities, for sale in foreign countries, that are illegal to buy in America... my head hurts. I think I need some drugs.

    30. Re:Article Mentions Problems in U.S. Also by mqduck · · Score: 1

      Puerto Rico is part of the USA. There are lots of Puerto Ricans who would be willing to fight you on that. And most USAmericans would disagree too. And anyone who is opposed to colonialism (like myself and Thomas Jefferson) would be thoroughly opposed to that statement (unless you include along with it the demand that PR be recognized as the 51st state).
      --
      Property is theft.
    31. Re:Article Mentions Problems in U.S. Also by tarlong · · Score: 1

      Having worked at a couple of big pharma processing plants here in Puerto Rico, i can only say that they take their quality assurance seriously. That said, like everywhere else we suffer from the bee complex. Once in, then you must be allowed to be in and no one takes much notice. So, a couple of blokes, who could care less, are hired to redo the paint jobs for the plant splattering paint about and no one notices until one of the Q&A guys takes his shifts sample. Most likely, as profit oriented companies usually do, his superiors won't hold the days shipments because he found some tainted pills. They wont dump the shipment based on "they might be tainted" grounds and just cross their fingers hoping nothing bad happens and if it does, well that's why we have lawyers on the payroll, no? I saw something like that happen once. It wasn't pills, but still it was supposed to be sterile non-surgical stuff. The dudes doing some cleaning job were outside hired help and did not know/cared for the stations rules, so they were going about carelessly and splattered dirty water / soap water near an unbagged, unfinished load. The Q&A people found out later that day when they took their required samples. The whole thing was shipped even when the Q&A team asked permission to trash the mornings load. The Q&A team leader and the production manager had quite a spit over the issue. To my knowledge, that was the only time something like that had happened there.

      --
      What? A beutiful butterfly you say? And how exactly are you going to turn into a beutiful butterfly then?
    32. Re:Article Mentions Problems in U.S. Also by Anonymous Coward · · Score: 0

      I was simply pointing out that it isn't a state but a territory as the parent post indicated it was.

      Wow, so not only do you not understand how the country you live in is put together, but you also have terrible reading skills. The parent post never said PR was a state - he merely said that it is part of the United States (which it 100% is). Funny that you really can't seem to admit that you fucked up. Instead you keep on trying to claim (wrongly, I might add), that PR isn't part of the US, even though everything says that it is. Sure, it's not a "state", but there are a whole fuckload of pieces of the US that aren't "states". They're still part of the United States, though.

    33. Re:Article Mentions Problems in U.S. Also by Faw · · Score: 1

      I'm offended!!!

      Calling us Puerto Ricans "wetback, siesta-sleeping, lazy ass latins". How dare you mix up your ratial slurs!! Those are mexicans...

        1. wetback: meaning they swam across the Rio Grande to get into the US (I guess cubans should be called the same)
        2. siesta-sleeping: we don't have that tradition here, don't know if mexicans still do this, this tradition comes from Spain
        3. lazy ass - I guess we all fit this category

      If you want to refer to us please do some research. Consult the Ratial Slur Database :)

    34. Re:Article Mentions Problems in U.S. Also by My+Iron+Lung · · Score: 1

      And for those Lost diehards.. this is how you can a job there:

    35. Re:Article Mentions Problems in U.S. Also by hjf · · Score: 1

      come on, I'm from Argentina, I'm white, tall, 100% European ascendancy (have you noticed that they have so many racial issues, they're the only ones who care about how much percentage of a "blood" they have in their veins?)... but the moment I open my mouth and a word in spanish comes out of my mouth, in their minds, I'm 5ft, I'm wearing a "sombrero" and smoking a cuban cigar while chewing on coca leaves, playing "soccer" on the beaches of Brazil! (or Spain?) and I'm probably too lazy to have a job. Like all arabs are terrorists, and all Frenchmen are chickens, and all the germans are nazis, and all the italians are in the mafia, and all blacks are gangsters.

    36. Re:Article Mentions Problems in U.S. Also by PopeRatzo · · Score: 1

      You want the FDA to get anal retentive on your medications, fine.
      eldavojohn, I'm with you.

      Considering the fact that the parties that stand to benefit the most from this story are the Big Pharma companies, and considering that 99 percent of all news stories come from press releases put out by flacks, I'm not the least convinced that this isn't part of a FUD campaign to counter even John McCain's willingness to stop Pharmas price-gouging of the US market.

      I'm alive today because of an outrageously expensive drug (non-hodgkins lymphoma, I'm fine now) which I could never have afforded (and my insurance company would have denied me) if it wasn't for the fact that I was part of a drug-trial and the stuff was free to me (along with some 1st-rate care- God Bless Northwestern Medical Center).

      I think Big Pharma's going to overplay their hand, though, and I believe (I hope) that in a few years we're going to have a health-care system in the US as good as the best European ones. It's embarrassing to live in the US and know that penny-ante countries in Eastern Europe have better health care than we do.
      --
      You are welcome on my lawn.
    37. Re:Article Mentions Problems in U.S. Also by EastCoastSurfer · · Score: 1

      Just realize those expensive drugs are going to get a little more expensive and sick people who are poor might not be able to afford them anymore.


      As long as Hilary or Obama wins, the gov. is going to pay for all my meds anyways!
    38. Re:Article Mentions Problems in U.S. Also by TubeSteak · · Score: 1

      I misspoke when I said "advertising" instead of "promotion".
      You understood it to mean "direct to consumer advertising" which wasn't my intent.

      --
      [Fuck Beta]
      o0t!
    39. Re:Article Mentions Problems in U.S. Also by Some_Llama · · Score: 1

      "You're missing a significant issue. If paint flecks can get in, what else is getting in there?"

      the summary explains paint flecks got ON the pills, not in them, when they covered the bins used to store the pills the problem went away.

    40. Re:Article Mentions Problems in U.S. Also by bobcat7677 · · Score: 1

      Whatever... When I was in Puerto Rico last year the tour guide was very proud to point out that the majority of prescription drugs sold in the US are made there. All the major players make their stuff there. The fact that Q/C broke down in a particular factory has nothing to do with the location. It's not like they purposely painted the pills with lead paint or anything.

    41. Re:Article Mentions Problems in U.S. Also by Anonymous Coward · · Score: 0

      navassa island (Navase) belongs to Haiti.

    42. Re:Article Mentions Problems in U.S. Also by heybo · · Score: 1

      Let's not forget about Indian Reservations. They are not part of the "United States" but land held (seized) "In Trust" by the US Government. Tribes are still Nations. I don't think you could call us Foreign Nations either. You are right there is a lot more to the US than just the States.

    43. Re:Article Mentions Problems in U.S. Also by instarx · · Score: 1

      I'd love it for the FDA to get anal retentive about inspection regimes.

      If you knew anything about the pharma industry, [...] You are like the pot calling the kettle black when you acuse someone of not knowing anything about the pharmaceutical industry and then make a dumb statement like you'd "love it if the FDA got [strict] about inspections". The FDA is *very* strict about GMPs (Good Manufacturing Practices) in the pharmaceutical industry. What happened here is that the company violated the regulations in 1)allowing the contamination in the first place, 2)not reporting it to the FDA immediately, and 3)not recalling the drug batches that could have been contaminated. After working in the Pharm industry for many years I assure you that the FDA's GMP procedures DO cover paint chips in the drugs. That is one company that will get very tired of FDA inspectors on-site for the next five to seven years.

      The high retail price of drugs bears almost no relation to its cost, That depends on how you define "cost". Sure, once the drug is discovered, evaluated, tested, and approved the actual cost of squishing into a pill and putting it in a bottle is trivial, but those upfront cost are VERY high.

      ...partially because the drug industry spends more on advertising than R&D, That is simply NOT true. Oh, they spend a bunch on promotion (not just advertising), but they spend much, much more on new compound research and Phase I, II and III testing. What is bad is that they often lump their promotional costs in with their R&D costs to inflate the figure, but still the R&D part is a lot more than the promotion part.

      I'm no apologist for the drug companies - their profits are obscene and their ethics questionable (to say the least), but there isn't any reason to misrepresent the real situation by making stuff up.
  3. DO NOT WANT! by Anonymous Coward · · Score: 0

    Not our little territory!

  4. How naive by Anonymous Coward · · Score: 0

    "They're making products that save or support lives, so it's not in their interest to make products that are unsafe or ineffective," he said. "I think they're good corporate citizens by and large and want to do right by their patients." Ahahahaha!! Oh jeez, that's a good one -- wait, you thought you were being serious?

    Ask anyone in the pharmaceutical industry - there's no money in actually curing people.
  5. What a bunch of pansies by SwordFishData · · Score: 4, Funny

    A little paint never hurt anyone! When I was a child, paint was considered a delicacy! It was like getting a piece of plasterboard with a prize!

    --
    Check out Erie, PAs one and only industrial metal band: DisgraceD
    1. Re:What a bunch of pansies by Red+Flayer · · Score: 2, Funny

      A little paint never hurt anyone! When I was a child, paint was considered a delicacy! It was like getting a piece of plasterboard with a prize!
      I think the lead in that paint may have had more of an effect than you think.

      Besides, when I was a young'un, the plasterboard would have been the prize. We had to make our own drywall from gypsum lumps and the paper we made by chewing up wasps nests and spitting out the eggs, larvae, and wasps to make pulp.
      --
      "Trolls they were, but filled with the evil will of their master: a fell race..." -- J.R.R. Tolkien on Olog-hai
    2. Re:What a bunch of pansies by Anonymous Coward · · Score: 0

      So paint was like the icing on a plasterboard cake. I bet wet paint was even better...

  6. Amazing by Anonymous Coward · · Score: 0

    We need to get the drug's manufacturing back into countries that can control their QA; USA, EU, Canada, Australia, japan, etc. This is absolutely insane.

    1. Re:Amazing by Anonymous Coward · · Score: 0

      Let's bring it back into the USA... from the USA. RTFA.

  7. Two observations by Red+Flayer · · Score: 5, Insightful
    FTA:

    The FDA's San Juan office has 22 inspectors who devote about a quarter of their time to pharmaceutical plants. They typically visit the factories once every two years, more often if there are consumer complaints or the company has repeated infractions.
    [snip]
    Scharmann, a consulting editor for the watchdog publication Dickinson's FDA Review, said the FDA is concerned by anything that affects drug quality but considers the likelihood that the companies may file legal challenges to enforcement actions.
    Two interesting things there -- first is that plants are only inspected every two years unless they are flagged due to poor prior performance or consumer complaints. Why not have inspections with a random interval? Yah, I know -- cost. But considering how many pills these plants pump out, you'd think there'd be stricter oversight. Or is it that we just trust pharmaceutical companies to do the right thing (which means avoid the nightmare of tainted pills splashed across the evening news)?

    Other interesting point is that the FDA chooses not to fine companies/enforce regulations because of the cost of responding to legal challenges from the manufacturers. What excatly is the point of having oversight and inspections, then? Basically, the FDA must have crystal-clear evidence of plant-to-market malefeasance before they can do anything.

    I guess the pharma industry has gotten their money's worth with their campaign contributions. A hamstrung FDA on a shoestring budget means strong profits for big pharma.
    --
    "Trolls they were, but filled with the evil will of their master: a fell race..." -- J.R.R. Tolkien on Olog-hai
    1. Re:Two observations by repapetilto · · Score: 1

      That's what I was thinking. So at what point is the FDA accountable for letting something bad be distributed?

    2. Re:Two observations by Anonymous Coward · · Score: 0

      Vote for Ron Paul! We'll just let the market sort this one out.

    3. Re:Two observations by Red+Flayer · · Score: 1

      Well, it is possible for states to sue a federal government agency for failing to uphold the law. The tricky part is proving damages and culpability. As long as the FDA comples with the letter of the law, no chance.

      It's kind of tough when the regs governng the FDA are written by the people they are supposed to regulate... take a look at who gets to serve hgh up in the FDA. Almost all of them are ex-pharma execs.

      --
      "Trolls they were, but filled with the evil will of their master: a fell race..." -- J.R.R. Tolkien on Olog-hai
    4. Re:Two observations by conlaw · · Score: 1

      So at what point is the FDA accountable for letting something bad be distributed?

      This all depends on your definition of "something bad." If you really want to have your stomach turned, read the FDA regulations (Title 21, Chapter 1 of the Code of Federal Regulations, available from http://www.gpoaccess.gov/cfr/index.html) on how many insect parts are allowed in your daily bread (or crackers or cookies). After reading those regs for a while, a few paint chips will seem innocuous.

    5. Re:Two observations by jdanton1 · · Score: 1

      22 observers at San Juan strikes me as light, given the number of plants on the island. However, the every two years thing isn't that bad. When the FDA comes in for in audit, they aren't just sampling product and doing QA testing on it. They are insuring that you as a pharmaceutical company have processes and procedures in place to ensure the quality and efficacy of your product. Basically, they are auditing your process more than your product. Even down to an IT level, extensive change control is necessary to be in compliance with FDA cGMP (current Good Manufacturing Practices)

    6. Re:Two observations by Anonymous Coward · · Score: 0

      TXT available here

    7. Re:Two observations by Anonymous Coward · · Score: 0

      So at what point is the FDA accountable for letting something bad be distributed

      Sometime after the people actually responsible for distributing it get held accountable?

      Oh, but actually holding people who do the damage responsible for the damage they do, why that's anti-american communist talk there.

    8. Re:Two observations by compro01 · · Score: 1

      eh. i've known about that insect stuff for years, and honesty, it doesn't bug me. i'd still be more worried about the paint (and if paint can get in, what else?)

      interestingly, a pound of ants is healthier (higher in protein and practically 0 fat) than a pound of lean ground beef. also, I've never heard of anyone having adverse effects from ingesting bee/wasp/whatever venom.

      --
      upon the advice of my lawyer, i have no sig at this time
    9. Re:Two observations by servognome · · Score: 1

      Why not have inspections with a random interval? Yah, I know -- cost. But considering how many pills these plants pump out, you'd think there'd be stricter oversight. Or is it that we just trust pharmaceutical companies to do the right thing (which means avoid the nightmare of tainted pills splashed across the evening news)?
      There are different kinds of oversight. It doesn't make sense to do plant inspections all the time because what you really are inspecting are the systems not what is getting made. There should, however, be more regular oversight of what is getting made in terms of reviewing documentation and quality test results.

      Other interesting point is that the FDA chooses not to fine companies/enforce regulations because of the cost of responding to legal challenges from the manufacturers. What excatly is the point of having oversight and inspections, then? Basically, the FDA must have crystal-clear evidence of plant-to-market malefeasance before they can do anything.
      I agree, the FDA shouldn't have to fight things in court. Unless you give them absolute authority, the system breaks down.
      --
      D6 63 0D 70 89 81 BB 8E 7B 7C 5F 5D 54 EA AB 73
    10. Re:Two observations by Red+Flayer · · Score: 1

      There are different kinds of oversight. It doesn't make sense to do plant inspections all the time because what you really are inspecting are the systems not what is getting made. There should, however, be more regular oversight of what is getting made in terms of reviewing documentation and quality test results.
      Good point.

      I think that plant inspections should follow more on the line of financial audits. Full process audits as done now, audit of process adherence regularly at more frequent intervals. When audits/inspections are so far apart, there is greater tendency for process exceptions to be mishandled or ignored (such as example in TFA).
      --
      "Trolls they were, but filled with the evil will of their master: a fell race..." -- J.R.R. Tolkien on Olog-hai
    11. Re:Two observations by LuisAnaya · · Score: 1

      Money... really... When the average reported unemployment rate is 12%, they're not going to rattle the cage over a few pills if they do not have a solid case. Keep in mind that PR is an important pharma powerhouse, not including being one of the biggest rum producers in the world. Lot of money involved.

      --
      Vi havas e-poston.
    12. Re:Two observations by instarx · · Score: 1

      Two interesting things there -- first is that plants are only inspected every two years unless they are flagged due to poor prior performance or consumer complaints. Why not have inspections with a random interval? Yah, I know -- cost. But considering how many pills these plants pump out, you'd think there'd be stricter oversight. Or is it that we just trust pharmaceutical companies to do the right thing (which means avoid the nightmare of tainted pills splashed across the evening news)?

      Other interesting point is that the FDA chooses not to fine companies/enforce regulations because of the cost of responding to legal challenges from the manufacturers. What excatly is the point of having oversight and inspections, then? Basically, the FDA must have crystal-clear evidence of plant-to-market malefeasance before they can do anything. Usually I would agree that it is not possible to over-estimate US industry's willingness to get around regulations to save money (lead in toys is the most recent example), but as far as the pharm industry's manufacturing practices I have to disagree. I have several decades of experience in pharmaceutical safety so I know a bit about this.

      At least for the major pharm companies, Good Manufacturing Practices are of paramount importance. Yes FDA inspectors may come by on average once every two years to a facility that has a good record (not as you have inferred - on a two-year schedule) but the pharm companies themselves have GMP auditors that visit every facility much more frequently. Before you scoff at that, there are several reasons why these internal inspectors are taken very seriously: 1) the threat of a lawsuit from a contaminated drug, 2)the threat of sanctions against the company by the FDA, 3)bad publicity, 4)loss of sales of the drug in question, and last but not least 5)the loss of manufacturing capacity that may cause a shortage of the drug worldwide (a very bad thing for both patients and the company). Just the hint that the FDA may close a line (not even the whole plant) is a major seismic event in the pharma industry. Oh yes, and some pharm employees actually want to keep their drugs safe - remember, we take drugs, too.

      You imply that there are never any Federal penalties for poor GMP practices by pharm companies, and that is not true at all. When FDA inspectors find a serious or chronic problem they will shut that plant down in a heartbeat and the pharm company then has to get it re-certified to manufacture pharmaceuticals again - and that is a Very Big Deal and very time consumming. The plant then has to operate under a consent decree for many years with much more supervision by inspectors and much, much more frequent and onerous recordkeeping and reporting rules. You can also bet that the plant manager and several of his staff will be looking for new jobs outside the pharm industry.

      Most of these contamination problems that you read about (but not all, true) come from smaller companies who ARE trying to game the system but get caught. Of the two large pharm companies I worked for I never thought either were trying to game the GMP system. They could be unethical in other areas (which I won't get into here), but not in the quality of their manufacturing.
    13. Re:Two observations by Red+Flayer · · Score: 1

      Thanks for the insight.

      I agree, by-and-large, that the major players play by the rules.

      I guess I got caught up a little bit in the sensationalism of the article :) -- and perhaps I didn't take enough of it with a grain of salt.

      --
      "Trolls they were, but filled with the evil will of their master: a fell race..." -- J.R.R. Tolkien on Olog-hai
  8. Hyping one risk, ignoring another by Eukariote · · Score: 4, Interesting

    Certainly, we should beware of iffy medication imported from abroad. But are the approved domestic drugs and treatments that safe? Have a look at these statistics: http://www.wnho.net/deathbymedicine.htm. Close to a million deaths in the US, each year.

    1. Re:Hyping one risk, ignoring another by Anonymous Coward · · Score: 0

      Read those stats again. You'll notice that drugs were only *part* of the total. And having an adverse reaction to a drug is not the same as dying from that drug. Please don't be so alarmist when you don't even know how to read and think.

    2. Re:Hyping one risk, ignoring another by mrbluze · · Score: 1

      Add to this death by non-compliance with medication, lack of medication/not being on medication, despite medication, non-prescription medication, over-the-counter medication, poisoning (all poisons are potentially medication!), suicide by medication, choking on medication and avoiding all of the above including food and water which potentially contains medication (anorexia), and you can pretty much include all deaths in the US and declare everything to be bad.

      I think I'll just get all depressed now and go and eat chocolate.

      --
      Do it yourself, because no one else will do it yourself. [beta blockade 10-17 Feb]
    3. Re:Hyping one risk, ignoring another by maxume · · Score: 1

      At most, 500,000 of those deaths are drug related(the others are related to problems endemic to being sick and in the hospital -- bad care, infections, etc). Of those 500,000, if you don't know how many of them were simple allergic reactions, you really can't say much about the safety of the drugs(to the general population -- or is peanut butter not safe?). It would probably also be good to separate out both accidental and intentional overdoses(because the notion of an overdose implies that a safe dosage is known).

      Until you do at least that much, you also are hyping.

      --
      Nerd rage is the funniest rage.
  9. Diltiazem? by sexconker · · Score: 1

    Does that mean Mezaitlid has to go back to the 5th dimension?

    (Kltpzyxm!! http://en.wikipedia.org/wiki/Mister_Mxyzptlk)

  10. Three Letters by alphasubzero949 · · Score: 1

    GMP or in this case the lack thereof. Where was their QA in all of this?

    1. Re:Three Letters by Attila+Dimedici · · Score: 1

      GMP or in this case the lack thereof. Where was their QA in all of this? For those who don't know, GMP stands for Good Manufacturing Practice. There is an important point mentioned in the article that comes further down than most people read.
      "David Elder, director of enforcement in FDA's regulatory affairs office, said pharmaceutical companies generally fix problems on their own and issue recalls if necessary once notified."
      This is the important point.
      --
      The truth is that all men having power ought to be mistrusted. James Madison
  11. Mmmmmm... by largejunglecat · · Score: 1

    Blue is my favorite flavor of paint chips. Need to score me some of these drugs. Seriously though, I think this is ridiculous. I mean, sure, a little paint is probably not going to hurt anyone, but if paint chips are mixing in with the drugs, you have to wonder what else might fall in there (i.e. rodent droppings, etc.). It amazes me that the FDA is tolerant of operations that just leave bins full of drugs open out on the manufacturing floor.

  12. Even worse are the counterfeit and low-strength. by Ungrounded+Lightning · · Score: 3, Informative

    Another problem has been pills that have low (or nill) active ingredient concentration. Some of these are generics - others are just flat-out counterfeit.

    A particular problem is thyroid hormone - which even normally has significant variation of activity between brands. Fine tuning of the concentration during is necessary to prevent serious ill effects (including permanent brain damage or death). So substituting a pill with a different strength can be a serious hazard. (That is why endocrinologists prescribing it will normally specify the brand or manufacturer and "do not substitute".)

    Unfortunately, both generics with virtually no active ingredient and actual counterfeit pills with no active ingredient at all have been making their way into insurance company pharmacy plans from foreign manufacturers. (Recently a doctor studying this had the experience of cutting a pill in half and finding that it was fake. The real manufacturer's product had an internal layer that was missing in the counterfeit.)

    --
    Bantam Dominique roosters crow a four-note song. Once you've heard it as "Happy BIRTHday" you can't NOT hear it that way
  13. Aint Offshoring/Outsourcing Wonderful!!! by Anonymous Coward · · Score: 1

    The company was Canadian! And don't forget that Puerto Rico doesn't want to become a full member of the United States. THEY keep voting down becoming a STATE! They like all the money, but none of the responsibility...that spells Third World to me!

    Got to love the rash of problems that are coming home from offshoring!

    Better check your credit rating too since large numbers of people have had their identities stolen in Indian, Philippine, etc call centers.

    Enjoy your New World Disorder suckers!

    1. Re:Aint Offshoring/Outsourcing Wonderful!!! by tomhudson · · Score: 2, Funny

      Got to love the rash of problems that are coming home from offshoring!

      Hawaii called - they're a mite pissed with you.

      ... and also some people on a big island off the eastern shore, in the state of New York ...

    2. Re:Aint Offshoring/Outsourcing Wonderful!!! by blindseer · · Score: 1

      ... and also some people on a big island off the eastern shore, in the state of New York ...

      Of course, how could I forget about Rhode Island.
      --
      I am armed because I am free. I am free because I am armed.
    3. Re:Aint Offshoring/Outsourcing Wonderful!!! by LuisAnaya · · Score: 1

      I'll presume that you mean taxation as responsibility because Puertoricans have been served (and drafted for WWI, WWII, Korea and Vietnam) in the US armed forces. The reason why they keep voting down is because they do not want to be forced to speak in English. But rest assured, Congress does not want PR to become a state either. It's a marriage of convenience.

      --
      Vi havas e-poston.
  14. this time? by biased_estimator · · Score: 3, Interesting

    ...tainted pills that have arrived in the US from -- not China this time -- Puerto Rico.
    Have tainted pills come from China before? I know about all the other hooplah...
    1. Re:this time? by ScrewMaster · · Score: 1

      I'm not sure about tainted ones, but there's been a number of reports of counterfeit drugs coming from China. I read about one a while ago where the pills were the right shade of blue but were made from plaster! A woman died from it (well, not from the plaster but from her condition, which the fake pills didn't treat too effectively.)

      --
      The higher the technology, the sharper that two-edged sword.
    2. Re:this time? by mqduck · · Score: 1

      Have tainted pills come from China before? Not that I know of, but the article certainly didn't say that they have. The point was that it was against what might have been your expectations.
      --
      Property is theft.
  15. meh by akirapill · · Score: 1

    I've been seeing tainted foreign pills for years. If you're lucky you just get a bunk roll or a speed bomb, but this one blue Chanel I had was bad news and I don't think it was paint chips.

  16. Re: Prescription drug prices by adminstring · · Score: 1

    Pretty much all generic drugs are sold without a crazy profit margin, since there's a competitive free market in the manufacture of generics.

    For brand name drugs, good business sense would dictate that they set the profit margin wherever it nets them the highest total profit - too high and not enough people will buy it, too low and they don't make as much as they could per pill, but if they get it just right they make the most money. Apparently there is enough demand for some of these drugs in the current system to make that "optimum" price level pretty high.

    I think the important question to ask is "what system for developing and distributing drugs could maximize innovation and at the same time maximize everyone's access to these products?"

    It's probably not the current system, and a lot of different factors are involved here - the nature of corporate-university relationships, current FDA regulations for testing (some of which are neither efficient nor safe), advertising, the influence of the corporate drive for profit on the actions of pharma companies, and the nature of the insurance industry.

    Good luck getting all of that straightened out in our lifetimes...

    --
    My truck is like a series of tubes.
  17. Revised options: by BeeBeard · · Score: 4, Funny

    1. You take the blue pill and the story ends.

    2. You take the red pill and you stay in Wonderland, and see how deep the rabbit hole goes.

    3. You take the blue speckled pill and develop serious health issues.

    1. Re:Revised options: by Jarik_Tentsu · · Score: 1

      Neo: There's blue speckles in my red pill...
      Morpheus: What!? Cypher, you been buying those cheap damn Puerto Rican made stuff again?

    2. Re:Revised options: by Hillgiant · · Score: 1

      What about the green and yellow purple pills?

      --
      -
  18. No, Puerto Rico is not a state,... by msauve · · Score: 2, Informative

    and is not part of the United States of America (neither are Navassa Island, the US Virgin Islands, American Samoa, Baker Island, Guam, Howland Island, Jarvis Island, Johnston Atoll, Kingman Reef, Midway Atoll, the Northern Mariana Islands or Wake Atoll). It is a commonwealth, and a US insular area.

    --
    "National Security is the chief cause of national insecurity." - Celine's First Law
    1. Re:No, Puerto Rico is not a state,... by Anonymous Coward · · Score: 0

      I'm not sure you know what it means to be part of the United States of America. By your definition, Washington DC is not part of the USA either. Nor are military bases or embassies. Or even naval ships. Man, how did that happen!?! It's a good thing you were here to let us know. Now we can fix the fake state of The Commonwealth of Virginia.

      For enlightenment, read over http://en.wikipedia.org/wiki/U.S._state

    2. Re:No, Puerto Rico is not a state,... by bytesex · · Score: 1

      Oh, you mean a /colony/.

      --
      Religion is what happens when nature strikes and groupthink goes wrong.
    3. Re:No, Puerto Rico is not a state,... by Anonymous Coward · · Score: 0

      100% correct. I've often said that those jerks living in the Commonwealth of Massachusetts are clearly not living in the USA.

  19. It's not the paint by Anonymous Coward · · Score: 0

    I, for one, would be more than a little disturbed if I thought I was getting the blue pill, but was in fact getting the red pill.

  20. Simple Solution by Anonymous Coward · · Score: 1, Interesting

    Simple solution:
    First offense: The company has its patent for this specific drug revoked. Second offense: ALL drug patents of the company will be voided.

    Make an example of the first one or two corporations that feel like testing the waters concerning this and see how now one else will be stupid enough to pull this off again.

    Some preemptive refutals:

    "The corporations have a right/obligation to turn a profit for their inventions": No, in this case they don't. The manufacturing company is clearly and maliciously not holding up their side of the contract, so why should the society need to?

    "Drug corporations will simply not sell their drugs anymore in this country": If you make a good enough case, Europe and Japan will follow suit and react in the same way, since it will lower their healthcare costs. China is still too small a market for expensive medicamentation, so where will the drug corps sell their expensive products then, if they boycott North America, Europe and Japan?

    1. Re:Simple Solution by Anonymous Coward · · Score: 0

      You're a total idiot. You should know that the government is in the pocket of big pharma. Keep dreaming.

    2. Re:Simple Solution by tomhudson · · Score: 1

      Problem with your plan is, where will we get our medications from? China?

      After all, if you're going to make them liable for manufacturing here, they'll just offshore it, and we all know how much contaminated stuff (toys, hard drives, etc) has come from China lately ...

    3. Re:Simple Solution by servognome · · Score: 1

      Problem 1 is define what an offense is. Manufacturing processes can have all sorts of issues and can range from minor - the sorting machine jammed and some pills are broken when shipped to major - this pill is actually poison.
      Problem 2 is that by revoking patents you essentially turn the industry into low cost generic manufacturers, which are the ones who will more willingly cut corners to save cost.

      --
      D6 63 0D 70 89 81 BB 8E 7B 7C 5F 5D 54 EA AB 73
  21. Right. by Nick+Driver · · Score: 4, Funny

    Besides, when I was a young'un, the plasterboard would have been the prize. We had to make our own drywall from gypsum lumps and the paper we made by chewing up wasps nests and spitting out the eggs, larvae, and wasps to make pulp.

    Right.

    I had to get up in the morning at ten o'clock at night, half an hour before I went to bed, eat a lump of dry poison, work twenty-nine hours a day down at the mill, and when we got home, our dad would kill us and dance about on our graves singing Hallelujah!

    You can't tell the young people of today that. They won't believe you.

    1. Re:Right. by Anonymous Coward · · Score: 1, Informative

      it's cold poison, actually... and you forgot that you also had to pay the mill owner to work there!

  22. I Had To Read The Summary Twice by milsoRgen · · Score: 1
    I had to read the summary twice, I could of swore it said:

    The first warning sign came when a sharp-eyed worker snorting pills...
    --
    I'm sick of following my dreams. I'm just going to ask where they're goin' and hook up with 'em later.
  23. Whoah! Don't taint me bro! by bobdotorg · · Score: 1

    Keep my pills away from your taint!

    --
    __ Someday, but not this morning, I'll finally learn to use the preview button.
  24. Do the managers of the US know what maintenance is by Yaa+101 · · Score: 1

    http://en.wikipedia.org/wiki/Maintenance

    I begin to wonder reading all these stories.

    In the long run it is actually cheaper to do maintenance.

  25. Not a tight regulatory sphincter in sight! by MillionthMonkey · · Score: 1

    You want the FDA to get anal retentive on your medications, fine.

    Is that where these little pills are coming from?

    Just realize those expensive drugs are going to get a little more expensive and sick people who are poor might not be able to afford them anymore.

    And since pharma companies spend twice as much on advertising as they do on research, it would mean fewer TV commercials to inform "guys like me, with eeee-deee", about the latest penis pills available. I'll have to turn off my spam filters to save my marriage!

    Honestly I've heard of worse things being found in food than this.

    When I was in fourth grade eating lunch in the cafeteria one day I saw a kid blow his nose into another kid's sandwich when he wasn't looking. Ever since then I've been eating dog kibble and saving $$$.

  26. These drugs are bad... by enoz · · Score: 1

    Mmmm'kay!

  27. Re: Prescription drug prices by timmarhy · · Score: 4, Insightful
    common misconception.

    health issues aren't ruled by supply and demand, especially on brand name drugs since the supplier can artifically restrict the supply without fear of competition. it's not like someone dieing has any choice (what price do you put on life?) and drug companies exploit this.

    capitalism is a decent system. but it's not an answer to everything, and one of those things is health care.

    --
    If you mod me down, I will become more powerful than you can imagine....
  28. At First... by rekab · · Score: 1

    I thought it said a sharp-eyed worker snorting pills...

  29. Re: Prescription drug prices by sumdumass · · Score: 1

    I agree. Many things should be considered a utility more then a market. Gas, Home heating oil, electricity, Public water, Medication and so on. There should be no or little market force on them outside the costs to deliver the products.

    Utility seems to be a generic term I like to use. But I like to use it because it is the one thing in a capitalist society that people don't mind regulating the profit margins of. We should be including Gas to some extent and medication into those groups. Medication for the reasons you mention, and Gasoline because public transportation in the US sucks donkey balls. People depend on driving to get to and from work. It may be because of bad decisions in the past as far as locating housing and so on but that it no reason to penalize the people of the present and future who are dependent on it today.

  30. Yeah but.... by pajeromanco · · Score: 1

    does this affect viagra?

    --
    Now I am sad.
  31. Drug patents and prices by Reziac · · Score: 1

    Remember too that "cheap generic drugs" is a euphemism for "expensive namebrand drugs whose patent has expired".

    --
    ~REZ~ #43301. Who'd fake being me anyway?
  32. Re:Even worse are the counterfeit and low-strength by thelexx · · Score: 1

    "Another problem has been pills that have low (or nill) active ingredient concentration."

    Yep, they're called 'homeopathic remedies'. Seen a couple of ads on tv, one was at least a full minute long, pimping homeopathic crap. Very disturbing.

    http://www.youtube.com/watch?v=BWE1tH93G9U

    --
    "Gold still represents the ultimate form of payment in the world." - Alan Greenspan, 1999
  33. Does this bother anyone else? by HangingChad · · Score: 2, Insightful

    FDA officials say the problems in Puerto Rico are proportionate with the large number of pharmaceutical plants here and generally no worse than those on the US mainland.

    Wow, I'm sure glad there isn't any more paint in our meds here on the US mainland than Puerto Rico.

    Remind me why the US pharmaceutical industry told us we were paying more for the same meds in this country? Something about safety...

    --
    That's our life, the big wheel of shit. - The Fat Man, Blue Tango Salvage
  34. If Puerto Rico isn't part of the USA neither is DC by Jonathan · · Score: 1

    By that "logic" Washington, DC is not part of the United States of America either as it too isn't a state. Much like Puerto Rico, it doesn't have the full rights of a state (neither DC nor Puerto Rico get congressmen or senators), yet it would be absurd to say that the capital isn't part of the USA.

  35. not surprised by annerajb · · Score: 1

    i am sorry saying this but i am from puerto rico and i am not surprise to hear FDA not being ... proper in their stuff its not common to hear stuff like this but is not surprising some places especially inspection companys like FDA and USDA do some strange stuff. like picus chiken factory they closed because of if i recall right bad chickens or soemthing. :S

  36. How about a patented medication tax? by Kaenneth · · Score: 1

    Since pharma companies make a TON more money on a drug before it's patents expire (Example, Zyrtec cost me $2 a 10 mg pill. Now that generics are out, you can get 100 for $14.99, about 15 cents a pill)

    How about a moderate tax on patent protected drugs, to help fund the FDA, who can then improve their inspection process. That can help keep out counterfeit drugs, ensuring that potential customers will only get your genuine products.

    That is, in exchange for the government granted monopoly, you give the government a small extra share of the profits. A percentage for every patent license. So that a patent owner pays a tax on what he gets from a 3rd party manufacturer.

    Not a tax on aquiring the patents, or on the drug itself. Once the patent has expired, the tax no longer applies to anyone, inventor or copycat. If you want to not have to pay the tax, you can simply disclaim your patent rights, and allow competition; or just not make and sell the product, in which case you have little claim to damages for 'lost market share'.

    Complications could include a patent on a non-therapeutic aspect of the drug, such as capsule design, coloring, labeling etc.

    But once I had this idea, I thought: 'Hmmm, what if this applied to ALL patents?'

    Claim your expensive software is 'patented', pay an few extra % to Uncle Sam. Patent your corporate 'Business Method', any revenue from that method is taxed a bit more.

    I guess that wouldn't stop patent trolls who don't actually make or sell a product... and it would add costs to 'defensive' patents. But an extra few % from every court judgement, or out-of-court settlement to fund the patent office could got a long way towards speeding up the process, and making it more accurate. Ideally companies would think before filing "Is this patent worth the added taxes".

    As a bonus to patent holders, anyone producing counterfeit goods would also be commiting tax fraud, meaning legions of IRS agents will help them find illegal copiers.

    No idea how/if this would mesh with internation patent law treaties, but it's not like the U.S. gives a damn about those.

    Still have the 'rule' that targetted taxes often affect unintended targets more than the intended ones. But what stops the drug companies from raising prices higher than they already are?

  37. Re:Even worse are the counterfeit and low-strength by The+One+and+Only · · Score: 1

    Yep, they're called 'homeopathic remedies'. Seen a couple of ads on tv, one was at least a full minute long, pimping homeopathic crap. Very disturbing.

    Please tell me they didn't make a full minute long version of "Head On! Apply directly to the forehead!".

    --
    In Repressive Burma, it's not just your connection that dies. slashdot.org/comments.pl?sid=314547&cid=20819199
  38. Re: Prescription drug prices by zippthorne · · Score: 1

    "what price do you put on life?"

    Let me turn that around for you. What price DO you put on life? Should drugs cost only what it costs to produce? Or should they cost what it's really worth? Keep in mind that the drugs only extend your life if they exist to do so.

    Obviously, the price should land somewhere in between those values. If you know of a better system that capitalism to decide that number, let us know.

    --
    Can you be Even More Awesome?!
  39. Re:Do the managers of the US know what maintenance by compro01 · · Score: 1

    http://en.wikipedia.org/wiki/Maintenance

    I begin to wonder reading all these stories.

    In the long run it is actually cheaper to do maintenance. who cares about long term? we need to raise that stock price 2 more cents this quarter!

    --
    upon the advice of my lawyer, i have no sig at this time
  40. Wrong question by hung_himself · · Score: 2, Insightful

    if you know of a better system that capitalism to decide that number, let us know.

    Essentially, the present system is to publicly (under)fund the difficult work of the basic science and then allow the private sector to patent the discoveries, remove them from the public domain, and massively profit.

    In exchange, they do the technically simple tasks of clinical trials, production and assessing which drugs to release back to the public using the criterion of maximizing profit (eg viagra) rather than the health of the population (eg antibiotics or AIDs drugs for Africans).

    The question should be "If you know of a worse system to develop drugs and therapies, let us know..."
    1. Re:Wrong question by zippthorne · · Score: 1

      You do realize that Viagra is an exceptionally poor example of the problem you're trying to illustrate. The story is well known, and pretty much precisely the opposite of your claims. Pfizer was looking for heart medications when they stumbled upon it. Realizing its marketability and the amount of suffering it relieves, they chose to market it.

      An entirely publicly run research effort may very well have decided that a treatment for ED was a luxury, and ceased any effort beyond a note in a database, or an obscure journal at best.

      Certainly, it's not as romantic as curing cancer or Ebola, but it affects a lot of people, who are apparently quite grateful to have it. But if you're arguing that when a part of the body doesn't work right, people should just suck it up if their plight is funny, your compassion could use a little work.

      --
      Can you be Even More Awesome?!
    2. Re:Wrong question by hung_himself · · Score: 1

      Pfizer was looking for another blood pressure medication - because blood pressure medications make money - people don't get better and they need to take it regularly.

      You may be right that a publicly run research effort may have decided ED was a luxury but even so - what likely would have happened is what did happen - people testing the drug for hypertension would have reported its side effect and then people would have started using it without big pharma. Google melanotan and PT-141 and tanning if you want to see this happening as we speak and how the presence of patents and and for profit isn't "helping" the process along. While you're at it Google Parkinson's and nerve growth factor and see the effect that patents had on restricting research for one of the few avenues for a cure to this disease. Meanwhile, massive amounts of money are spent on developing slightly different particle sizes and delivery systems to extend patents on proven money makers for lifelong treatments

      To me the money spent marketing Viagra/Levitra/Cialis could have been much better spent on trying to help the 0.5 Billion people who suffer from malaria of which roughly one Chicago's worth of people die each year and for which the best drugs have been developed for the cattle that graze in the sub-Sahara.

      Yeah - I'm the one with misplaced priorities and lack of compassion...

    3. Re:Wrong question by zippthorne · · Score: 1

      "to me the money spent marketing Viagra/Levitra/Cialis could have been much better spent on trying to help the 0.5 Billion people who suffer from malaria of which roughly one Chicago's worth of people die each year and for which the best drugs have been developed for the cattle that graze in the sub-Sahara."

      And again, in that particular case, you're way off the mark. The money spent marketing it is irrelevant precisely because it's a good deal smaller than the profit made from that marketing. That profit might be better spent in the way you say, though. Why don't you see if you can convince the pharma companies to put it to that use, without reducing their (already low as you say) actual research components.

      If you want to help the people with malaria, maybe you shouldn't be so keen on preventing pesticide use. DDT might not be effective as it once was, but it would've saved countless more lives if it had been used as extensively as it could have been when it was that effective. But I'm sure you're more satisfied with your coffee table books with dramatic titles getting people all up in a tizzy without rationally thinking things through.

      --
      Can you be Even More Awesome?!
    4. Re:Wrong question by hung_himself · · Score: 1

      And again, in that particular case, you're way off the mark. The money spent marketing it is irrelevant precisely because it's a good deal smaller than the profit made from that marketing.
      C'mon, think that one through please. That really is nonsensical. That money was spent - it came from drug sales (and expensed so part of it came from potential tax revenue). It could have been put to better use. The whole sum, not just the profits. If it had been a public enterprise for example, the revenue from drug sales could have been put into other more productive areas than trying to expand a the market for ED drugs.

      And the final part of your reply is really cheap. You have no idea what I do, or what my opinion is on DDT, or how little money is spent on malaria research. Probably less than a Superbowl spot for Levitra. If you knew the long term damage that was being done right now by cuts in NIH resulting in closing of labs and programs that will take years to rebuild perhaps you would think differently. If you knew how small the monies we are talking about relative to the wastage in the present system...

      Trust me, I'm not the armchair idealogue here reading the coffee table books. I only wish there were coffee table books that explain how drug research works and how broken the system is. Things are going to be very hard to change until enough intelligent people like yourself just step back and think whether there just might be a better way to do this.
    5. Re:Wrong question by zippthorne · · Score: 1

      NIH shouldn't be funding malaria research, since it doesn't affect Americans, who have access to effective mosquito control. If any governmental entity should be, WHO should be funding the lion's share, though.

      The system is not best which funds all diseases equitably. It is best which provides the most benefit to the most people. It must distribute resources between medical research, medical service, and other sectors which are necessary as well. And even on the research side, while there is certainly reason for long-term research into cures for common and even obscure diseases, it also must be balanced against what research can have the most benefit right now. A small benefit to a whole lot of people right now has some weight against a great benefit to a few people an unclear time in the future.

      You've discounted the benefit to the millions of people using Viagra, to make the money spent on marketing that drug look villainous. But the money isn't billed against the profits of "more worthy" previous drugs. It comes out of the profits of the drug it promotes. Only if the campaign failed would the money have come from the other drugs, and even then, it would've been cut off much sooner when it became apparent it wasn't effective. Further, at the time, the thing it treated wasn't really talked about very much. The sufferers might not have even been aware that a treatment was available. That's exactly the sort of situation drug marketing is supposed to be for.

      There might be a better way to do things, but most of the "solutions" I've heard have thrown about all of the benefits of the current system without really addressing the main issues, anyway. They mostly just shuffle the blame around without doing anything substantive. Some are abysmally naive in their assumptions of how "profit motive" works or is supposed to work.

      At the moment, the "last mile" work that the drug companies do is fantastically expensive and fraught with risk (both of liability and of failure). And drugs come out of patent protection relatively quickly after introduction, anyway, due to the length of the approval process. So I really don't see the problem here.

      --
      Can you be Even More Awesome?!
    6. Re:Wrong question by hung_himself · · Score: 1

      NIH should be funding the best science period. No one can predict what will lead to what at that stage. If Americans are too shortsighted to realize this, the research and benefits will be and is moving offshore. But the malaria example was not about whether WHO or NIH should fund research but that a rational system *should* encourage some allocation of resources for the world's most prevalent disease.

      The last mile work *is* fantastically expensive - no argument there *but* it is also fantastically profitable and the least risky of the entire pipeline. If it weren't, pharma would be doing the first steps too. I argue that it is fantastically inefficient. Your argument that it isn't wasteful seems to be predicated on infinite resources - that somehow because the money that went into Viagra came from people that paid for Viagra and that the advertising for Viagra came from Viagra profits that this is not wasteful. While I agree, it's not a zero sum economy, resources are limited and a system which encourages spending them on expanding a Viagra market, and shrinking Levitra's market is encouraging waste.

      I gave you the example of Parkinson's and GDNF, which although the ideas came out of public funded research, has been patented for use in Parkinson's. Amgen abandoned trials because of liability issues though it is a very promising therapy. However, they still own the patent which makes it difficult for anyone else to do the research.

      While we're with Parkinson's what about the attempts to market dopamine agonists as treatments for "restless leg syndrome" for which their efficacy is limited - but it does allow patents to be extended on these drugs by creating a market for a slow-release version, in case the slow-release formulation wasn't any better for Parkinson's during initial trials. This is a completely logical and natural consequence of the present system and extremely wasteful. We won't even get into the issue of delaying of drug release/development to get the maximum patent protection rather than trying to deliver the most effective product.

      These are examples of where the allocation of resources to maximize profit does not coincide with the best allocation of resources to benefit the health of the population. The existence of large black and gray markets for prescription drugs, banned, abandoned or unapproved drugs (PT-141 was an example), points to serious inefficiencies in the system in delivering what people want and need. It's true that you could fix a lot of these things with some common sense, more sensible regulation/licensing and tweaking the patent system and this is probably as much as the American public could be convinced of in my lifetime

      However, I look at NIH/NSF and how fantastically successful these public funded organizations have been at advancing basic research and providing drug leads while spending very little money. If we entrust them with these tasks, why not entrust them with, the admitted more expensive but also much less technically difficult steps involved in the last mile of drug development? It requires too much trust in governments I guess...

  41. Lies, Damn Lies, and Statistics by NIckGorton · · Score: 1
    OK, I had a look. From that article:

    It's very difficult to obtain accurate statistics when studying unnecessary surgery. Dr. Leape in 1989 wrote that perhaps 30% of controversial surgeries are unnecessary. Controversial surgeries include Cesarean section, tonsillectomy, appendectomy, hysterectomy, gastrectomy for obesity, breast implants, and elective breast implants. This is a good example of why Mark Twain was right. Take for example appendectomy which they cite as a 'controversial' unnecessary surgery. There is no controversy that an appendectomy is necessary for real appendicitis. Without it, you will likely die from complications. However, especially in the era before CT scans (when the article they cite was written) the certainty of the diagnosis of acute appendicitis was always in question.

    Faced with 100 patients with fever, right lower quadrant pain, and vomiting, 50 of whom have appendicitis and 50 of whom don't, you do 100 appendectomies. There is no way to know who really has appendicitis till you open them up. If you operate on no one, 50 people will die. If you operate on all of them none or very few will die.

    However, you can say retrospectively that you did 50 unnecessary surgeries.

    The same can be said for Cesarean Section. If you have 100 babies in distress, 50 might come out fine if you don't do a section. The other 50 are placed at risk of serious complications or even death. If you know prospectively who will do great, then you will never do an 'unnecessary section'. However neither the OB or the patient knows that so both usually choose to err on the side of caution.

    Of course that caution saves lives but allows fear-mongering pseudo-scientists whack-jobs to make statements like the World Natural Health Organization you cite. Its no wonder if you go to the main page they also don't believe in global climate change, are anti-gay-marriage, anti-vaccination, anti-flouride, anti-abortion, and anti-aspartame, whack jobs. They also hawk ministerial credentials, have a 'Responsibility in Free Speech' banner, a homeland security threat advisory, and a fetus near the bottom of their main page. http://www.wnho.net/

    Those are definitely the people I'd go to for my health care info. I'm sure that's completely unbiased.

    As a constructive suggestion though, the next time you'd like to make that point, you could do so without having to quote whack-jobs like those. The 1999 Institute of Medicine Report "To Err is Human" gives reliable figures, though the number of deaths is an order of magnitude less than the figure you quote. Its still an issue that needs to be addressed by systems change, but the sky isn't falling.
    1. Re:Lies, Damn Lies, and Statistics by Eukariote · · Score: 1

      World Natural Health Organization you cite. Its no wonder if you go to the main page they also don't believe in global climate change, are anti-gay-marriage, anti-vaccination, anti-flouride, anti-abortion, and anti-aspartame, whack jobs.

      The page I linked to was an abstract/introduction of a book by authors not associated with that website. If you have an issue with the book, take on the book and the statistics and references therein. For vaccinations, fluoride, and aspartame there is good research that shows that these are in fact quite toxic/damaging. For vaccines, a good well-sourced overview can be found here: http://astore.amazon.com/medical-bookstore-20/detail/1881217302. Fluoride toxicity has long been known. And for aspartame you only need to know that it metabolizes to formaldehyde to know enough.

      Of course, you will still think it to be nonsense because it implies something quite unbelievable: that millions of people are being knowingly put at risk, damaged, and poisoned. That can't be, can it? Well... there is a simple explanation for it all: this world is being run by genocidal maniacs. To see who these people are, take a look at the following big genocide that is not being reported on, yet is being executed more or less out in the open http://www.globalresearch.ca/index.php?context=va&aid=7957. Yup, Henry is still at it.

      Of course, in the west, we can't have overt genocide. It is essential that we believe ourselves to be free. Hence the deal with medication. It is perfect for covert genocide, and you can even have victims themselves pay for it.

    2. Re:Lies, Damn Lies, and Statistics by shalla · · Score: 1

      For vaccines, a good well-sourced overview can be found here: http://astore.amazon.com/medical-bookstore-20/detail/1881217302 [amazon.com].

      Ah, yes. That cutting-edge research from 2002 with one out of three reviews on the page commenting on how biased it is. There's a good source of information.

      Actually, there have been a number of studies recently looking at the association between vaccines and various illnesses/diseases/symptoms, particularly vaccines and autism. Every single one that I've seen published by a reputable scientist has found no link.

      There's also an article in the Jan 2008 Skeptical Inquirer about vaccine safety (particularly regarding autism).

      Lots of random charts in a book do not necessarily prove anything, except, possibly, that the shrinking number of pirates caused the rise in average global temperature. You need to have a context and know where the chart came from.

    3. Re:Lies, Damn Lies, and Statistics by sqlrob · · Score: 1

      And for aspartame you only need to know that it metabolizes to formaldehyde to know enough.

      And vitamin B12 metabolizes to free cyanide. Therefore, I assume you will stop ingesting food with it?

    4. Re:Lies, Damn Lies, and Statistics by Eukariote · · Score: 1

      And vitamin B12 metabolizes to free cyanide. Therefore, I assume you will stop ingesting food with it?

      Don't compare apples to oranges. One Diet Coke contain 135 milligrams of Aspartame. The recommended daily intake of vitamin B12 is 15 micrograms. Moreover, the toxicity mechanism is quite different: cyanide is an inhibitor of a specific enzyme, formaldehyde can cause many a-specific reactions, e.g. cross linking of protein chains.

      Also, consider that we have evolved to cope with a diet that includes vitamin B12, so from a purely evolutionary perspective you can be sure our bodies can cope with it in reasonable quantities. We have not evolved to cope with Aspartame.

    5. Re:Lies, Damn Lies, and Statistics by Eukariote · · Score: 1

      You need to have a context and know where the chart came from.

      Oh, I fully agree. Do you have that context and did you trace the sources of the charts? Nope, you did not. You read a review and deferred to its authority. Did you verify the research you quote that found no association between vaccines and risks? Nope, you believe them as they have been published by "reputable scientists".

      Consider that studies are easily bought and corrupted. If the reason for it all is what I say, the interests are so large that that is just what you would expect to happen. So, how can you really know if the studies you quote are correct? Two ways: look at the raw data and interpret it yourself, or look at who funded those that did the studies.

      Or just go back to sleep and take your flu shot each year.

    6. Re:Lies, Damn Lies, and Statistics by sqlrob · · Score: 1

      OK, so 135 mg would go to approximately 13 mg of formaldehyde, assuming all the methyl esters were metabolized

      So, that is lesse here...

      A whopping .026% more than the body produces under normal conditions in one day. So, I would say, yes, we're evolved to handle it.

    7. Re:Lies, Damn Lies, and Statistics by Eukariote · · Score: 1

      A whopping .026% more than the body produces under normal conditions in one day.
      0.026% more than the formaldehyde the body produces under normal conditions in one day? Let's see, that would mean that according to you the body produces 13mg*(100/0.026) = 50 grams of formaldehyde, each day. Bullshit.
    8. Re:Lies, Damn Lies, and Statistics by sqlrob · · Score: 1
    9. Re:Lies, Damn Lies, and Statistics by Eukariote · · Score: 1

      OK, point granted: the body can cope with the formaldehyde produced during normal metabolism. Does that mean that the formaldehyde from the potentially rather different aspartame metabolism can be coped with? Not necessarily. In fact, there is data that shows that it cannot.

      A Spanish research group has managed http://www.ncbi.nlm.nih.gov/pubmed/9714421 to trace where the formaldehyde produced during aspartame metabolism binds. They did so by radiolabeling the methanol group of aspartame. The formaldehyde was found to bind to protein and DNA in various tissues, with the adducts accumulating under prolonged exposure.

      This does beg the question how the formaldehyde is kept from doing damage during normal metabolism, as it is a pretty reactive molecule. Perhaps the normal metabolic pathway occurs inside a cell vacuole, thus keeping the formaldehyde segragated.

    10. Re:Lies, Damn Lies, and Statistics by shalla · · Score: 1

      Let's see. I said, "Ah, yes. That cutting-edge research from 2002 with one out of three reviews on the page commenting on how biased it is. There's a good source of information." And later in my comment, I stated that "You need to have a context and know where the chart came from."

      Your response? To quote only the last comment and then say: Oh, I fully agree. Do you have that context and did you trace the sources of the charts? Nope, you did not. You read a review and deferred to its authority. Did you verify the research you quote that found no association between vaccines and risks? Nope, you believe them as they have been published by "reputable scientists".

      1. Directing someone to information from 2002 on a medical subject is sketchy. Particularly when of the reviews on the page promoting the book, 33% of them thought it was slanted. I never claimed to have looked at the book and verified the charts in it. As a librarian, I'm trained to know what is and is not worth my time to look at--and that, as old as it is and with a no-name publisher, with only 3 reviews, and with 1 of those 3 being negative, indicates that the book would not make the shelves in a library as being a reputable source.

      2. For some reason, they won't let me give people vaccinations myself to test this, but since I've read enough information on several different studies (not just the ones listed here) on autism and vaccines, and the correlations that SHOULD be there just are not. But yes, who is funding the study is important information to know. However, I was keeping my post short and thought that links to a few sources might be enough to get people started on current research and articles on the subject.

      3. While I do not trust drug companies in general and think they'd do almost anything to make a buck, I think your conviction on this topic falls on the lines of paranoid conspiracy theory.

    11. Re:Lies, Damn Lies, and Statistics by Eukariote · · Score: 1

      Well, you can take your own arguments as sufficient to leave the subject rest. Or you can reserve judgment and take in further data. As to your first point: the book I directed you to is anything but sketchy, it is very well-referenced. If you don't trust the book, you can still trace the source material it references. If you don't care to invest money in it, here is a freely downloadable article that covers part of the topic, and it is well-referenced too: http://www.jpands.org/vol11no2/ayoub.pdf

      As to autism and vaccines, quite a few informed and qualified people are of the opinion that there is in fact such a link. You say the correlations are just not there. I am aware that there are quite a few (typically industry sponsored) studies that purport to show through statistics there is nothing to it. But then, let me point out the title of this thread. For an alternate opinion, download and watch the following video: http://www.mininova.org/tor/1113910

      As to conspiracies, well they do happen. Seeing well-funded and well-coordinated denial of realities obviously present in raw data pretty much implies conspiracy, But it leaves the question of why. Digging a little deeper, though, does allow a good case for an answer to the question "why?" to be made. The latter part of the following talk does just that: http://video.google.com/videoplay?docid=6890106663412840646

  42. MOD PARENT UP!!!! by NIckGorton · · Score: 1

    Not only are you right, but succinct. I can never say that in so few words. Can I copy that and use it later?

    1. Re:MOD PARENT UP!!!! by Anonymous Coward · · Score: 0

      LOL, be my guest - you might have guessed, that I'm not a very strong believer in IP...

  43. Re: Prescription drug prices by Anonymous Coward · · Score: 0

    And yet, it still is. If drug companies make drugs too expensive, fewer people can afford them -- that's still capitalism, though it make seem more gruesome than the cost curve for coffee beans.

    Also, letting drug companies make money, like any other company, to offset the cost of developing the drugs (including all the failed attempts) has been the most effective way we've found to come up with new drugs. I don't see anybody with a superior alternative to capitalist pharmaceutical companies, when it comes to cooking up new drugs.

    Capitalism might suck at health care, but for pharmaceutical research, it's still doing remarkably well. Or as they say about democracy, it's the worst possible system, except for all the others we've tried.

  44. Re:If Puerto Rico isn't part of the USA neither is by MiniMike · · Score: 1
    Actually, DC has a non-voting* delegate in the House. So not completely un-represented, just almost completely. For those who don't live near DC, and haven't had the benefit of seeing a car from DC swerving down a road near them, DC license plates now display the motto 'Taxation Without Representation'.

    *- still allowed to take bribes from lobbyists, just like 'real' congressmen,

  45. Idiot by Anonymous Coward · · Score: 0

    The Puerto Ricans have had many opportunities to become their own country.

    They have declined several times, it is speculated it's because they receive far more in U.S. subsidies than any perceived loss self-governance.

    However, we should probably talk about Wales. Those guys have been living under the thumb of british rule for almost 1,000 years.

    1. Re:Idiot by LuisAnaya · · Score: 1

      Read about COINTERPRO, Cerro Maravilla and about the Ponce Massacre. It has been more than just US subsidies. (which started in the 30's with the PRERA and PRA)...

      --
      Vi havas e-poston.
  46. Pill sorting machines help by ModelX · · Score: 1

    In EU there are quite strict rules about the coloring of pills and there's a company called Sensum producing machines that use computer vision to inspect and sort all kinds of pills. I guess Biovail Corp. needs to buy a pill checking machine such as this: http://www.sensum.si/

  47. Re:If Puerto Rico isn't part of the USA neither is by Anonymous Coward · · Score: 0

    But wait! Puerto Rico has a non-voting delegate in the US House of Representatives, too! Oh, and as a resident of DC, the license plates are one of the many options you can get (you're not required to get that particular design). I suppose you would also say that everyone in Missouri now must have a "Choose Life" license plate.

  48. Not as dangerous as herbal supplements by seanellis · · Score: 1

    I am surprised by the strong reaction to this minor contamination, when many people are quite happy to ingest unregulated herbal "supplements" with no oversight over purity or dosage. In fact, I predict that the strongest reaction to this will be from precisely those people.

    Supplementary, Complementary and Alternative Medicine should be subject to the same controls (including proofs of efficacy) as actual medicine.

  49. My HMO sells through own pharmacies. by MtViewGuy · · Score: 1

    As a member of the Kaiser Permanente HMO, I actually asked why Kaiser will only allow their prescriptions to be sold through their own pharmacies. The pharmarcist specifically said they want to ensure that the pills being prescribed were legitimate and try to avoid as much as possible the problem that plagued a number of drug store chains in the past, namely selling prescription pills that were actually fakes.

  50. Re: Prescription drug prices by khallow · · Score: 1

    common misconception.

    it's not like someone dieing has any choice (what price do you put on life?) and drug companies exploit this.

    You don't have a choice to avoid death, but in some places like the US you do hav a choice as to how much you spend to stay alive.

    capitalism is a decent system. but it's not an answer to everything, and one of those things is health care.

    Healthcare isn't free market. Most people are in insurance pools funded by employers (and I gather most of these plans are required by law). That means health benefits that at least partially seperate the cost of providing healthcare from the demand for healthcare. Demand will go up when someone else is paying for your healthcare.

  51. Re: Your Comment Title by sgilti · · Score: 1

    How about "Scathing Diatribe Highlights Growing Domestic Epidemic". Just saying.. it'd be hard hitting.

  52. Re: Prescription drug prices by sjames · · Score: 1

    Of all of the things you mentioned, medication has the least elastic demand of all. Even home heating has an elasticity to it since you can (however undesirable) turn the thermostat way down and wear a coat to reduce use. Gasoline can be conserved through carpooling, cutting out unnecessary trips, and in some cases teleworking and walking.

    OTOH, if you need life saving medical care, you have no viable alternatives. Taking it every other day or taking half doses may be worse than not taking it at all.

    Capitalism only works when consumers are well informed and have many choices including the choice to opt out of the market if its offerings are unattractive or unaffordable. The big "dark secret" of the "Capitalism uber alles" crowd is that those conditions don't exist in utilities and especially healthcare.

    Interesting logical thought: We have prescription laws based on the premise that the average consumer cannot know enough to decide for themselves what to take and how much. Capitalism cannot work when the consumer is ill-informed and cannot become adequatly informed. Lawmakers and economists in the U.S. claim that capitalism is effective in healthcare and pharmaceuticals. All three CANNOT be true at the same time.

  53. Penalties are cheaper than safety by rbanzai · · Score: 1

    Historically in the United States penalties for adulterated food and drug products are so small as to be laughable. For the last 100 years it has been far cheaper for drug companies to cast a blind eye toward safety and quality in favor of just eating the occasional penalty or lawsuit. Evem the larger penalties just result in a drug company reshuffling their ownership and credit credentials and just picking right up where they left off, poisoning and cheating their customers. Millions of people depend on prescription drugs and we're all basically helpless in the face of corporate malfeasance.

  54. Bad Summary and headline by Anonymous Coward · · Score: 0

    The pills were PAINTED, not TAINTED.

  55. No surprise. FDA has been gutted by Radical+Moderate · · Score: 1

    Bush has been bad but previous administrations have done their part to hack the FDA to the bone. In 1973, the F.D.A. undertook 34,919 food inspections; in 2006, that number had dropped to 7,783 according to the NY Times . And the number of inspectors has dropped by 1300 in the last 14 years.

    Funny that we can spend as much as the rest of the world combined on defense, but can't afford to make sure the food and drugs we put in our bodies are safe.

    --
    Never let a lack of data get in the way of a good rant.
  56. Re:Even worse are the counterfeit and low-strength by Ungrounded+Lightning · · Score: 1

    "Another problem has been pills that have low (or nill) active ingredient concentration."

    Yep, they're called 'homeopathic remedies'. Seen a couple of ads on tv, one was at least a full minute long, pimping homeopathic crap. Very disturbing.

    http://www.youtube.com/watch?v=BWE1tH93G9U Homeopathic remedies are a separate issue.

    What I'm talking about is products sold as a particular drug and strength which in fact are fakes with either a different (typically lower) strength or just no active ingredient at all.

    --
    Bantam Dominique roosters crow a four-note song. Once you've heard it as "Happy BIRTHday" you can't NOT hear it that way
  57. Re: Prescription drug prices by cayenne8 · · Score: 1
    "capitalism is a decent system. but it's not an answer to everything, and one of those things is health care."

    True, but, it is still better than having the US Fed. Govt. run it....

    --
    Light travels faster than sound. This is why some people appear bright until you hear them speak.........
  58. Re: Prescription drug prices by sumdumass · · Score: 1

    Of all of the things you mentioned, medication has the least elastic demand of all. Even home heating has an elasticity to it since you can (however undesirable) turn the thermostat way down and wear a coat to reduce use. Gasoline can be conserved through carpooling, cutting out unnecessary trips, and in some cases teleworking and walking.

    Well, not to the extent your wanting to make it. Sure you can turn the heat down but what is a reasonable amount? I mean if you got kids and are keeping the house at 50 degrees F in the winter, your kids are going to be finding the state taking care of them and you might be finding criminal neglect charges. Is having your children taken away and facing charges any different then life and death choices that are in effect more of a quality of life choice?

    I mean not all medications are prescribed to keep you alive. Some are to keep you functioning and a productive member of society. Some are to head off possible other conditions like heart attack or stroke which could be adjusted for by alteration in life styles too. And of course I doubt the antibiotics and decongestants people take to speed the recovery of colds wouldn't be considered life and death related. In all, a good majority of medications don't actually stop a person from dieing, it reduces risks to other conditions that could lead to death. So pretending that they are on some higher level is only skewing the situation. And ever with driving, not taking unnecessary trips or car pooling only results in a reduction of dependence, not a removal of it. Just like most blood pressure medication could be done away with or greatly reduce by dietary and lifestyle changes.

    OTOH, if you need life saving medical care, you have no viable alternatives. Taking it every other day or taking half doses may be worse than not taking it at all.

    Sure. But lets compare apples to apples and not skew the situation. The vast majority of medical care doesn't treat life threatening conditions. Pain medication of instance treats a quality of life situation and so on. Not all medication or medical car is life or death and for the purpose of comparing life and death, we need to rule out excess in home heating, gasoline and so on. If your ride doesn't show, you have to make it to work or get fired which means you lose your house or something else that ends up putting you on the street or jail or taking your kids away or all of the above. I mean when we are talking about extreme conditions, Life and death, ability to survive, or to provide for yourself, we need to keep the perspective real. All these things should be treated like utilities and controlled to some extent, even if it is just enough to keep them affordable.

    Capitalism only works when consumers are well informed and have many choices including the choice to opt out of the market if its offerings are unattractive or unaffordable. The big "dark secret" of the "Capitalism uber alles" crowd is that those conditions don't exist in utilities and especially healthcare.

    No, capitalism works when there is a "real" choice. When there isn't a choice because or market conditions, regulation, or whatever else, then the process goes out of ballance and becomes skewed to the benifit of companies. IT doesn't have to be an educated or informed choice, but there has to be a real choice there.

    I do agree that the conditions for capitalism doesn't exist in utilities though. Often with deregulation, it is only a partial deregulation and we are given the illusion of choice which fails to deliver. California is the biggest example I know of where the illusion was there and it failed miserably. Granted, they had one of the largest energy suppliers in the state illegally screwing them by committing fraudulent acts that drove costs up where is wasn't natural (price fixing and locking out competitors). They had been doing that before deregulations too but the effect incre

  59. Re: Prescription drug prices by sjames · · Score: 1

    Sure. But lets compare apples to apples and not skew the situation. The vast majority of medical care doesn't treat life threatening conditions. Pain medication of instance treats a quality of life situation and so on. Not all medication or medical car is life or death and for the purpose of comparing life and death, we need to rule out excess in home heating, gasoline and so on. If your ride doesn't show, you have to make it to work or get fired which means you lose your house or something else that ends up putting you on the street or jail or taking your kids away or all of the above. I mean when we are talking about extreme conditions, Life and death, ability to survive, or to provide for yourself, we need to keep the perspective real. All these things should be treated like utilities and controlled to some extent, even if it is just enough to keep them affordable.

    I can assure you, pain medication can be life saving. Since earning a living is manditory in capitalism (if you like eating), treating a condition that prevents working is no more elastic than a condition that is directly life threatening.

    I don't by any means argue that only healthcare is inelastic or even that all healthcare is, just that it TENDS to be moreso than other utilities. Agreed, freezing the kids (or even not actually endangering them at all, but making an uncommon choice in energy use) can cause problems from DFACS. However, it's perfectly acceptable to have the kids sleep in one room with a space heater while letting the rest of the house be cold. In more rural areas, a wood stove is a viable option.

    Electrical use by the elderly in summer is less elastic. Death from heat stroke is all to common for the elderly in summer.

    WRT to consumers being informed, I stand by my statements. Real choice is necessary, but no more or less so than informed consumers. You can't maximise value if you have no way to determine value in the first place. Poorly informed buying leads to mal-investment in cheap shoddy goods rather than the ones that cost twice as much and return 4 times the value.

    This ties back into the inelasticity of healthcare. Given adequate knowledge an informed healthcare consumer will know to request generics or even that the doctor may be 'overselling' antibiotics, perhaps as a CYA move. They might even be well enough informed to know when they don't actually need healthcare beyond first aid.

  60. Re: Prescription drug prices by sumdumass · · Score: 1

    I can assure you, pain medication can be life saving. Since earning a living is manditory in capitalism (if you like eating), treating a condition that prevents working is no more elastic than a condition that is directly life threatening.

    well, it is a good thing we don't live in a true capitalist society. Pain medication might mean no work, but then you would be poor and the government already steps in and it becomes a quality of life thing.

    I don't by any means argue that only healthcare is inelastic or even that all healthcare is, just that it TENDS to be moreso than other utilities. Agreed, freezing the kids (or even not actually endangering them at all, but making an uncommon choice in energy use) can cause problems from DFACS. However, it's perfectly acceptable to have the kids sleep in one room with a space heater while letting the rest of the house be cold. In more rural areas, a wood stove is a viable option.

    I know where your going with this and to a degree I support your decision. But I know a young mother who had her kids removed because the electricity was shut off at her house for a week in the middle of summer. I think your giving this idea of acceptable sacrifices a little too much credit. She eventually got them back but had to submit to random house hold inspections to ensure the utilities were on (water, electric, heat whether gas or electric)and there was a stock of food on hand. they even set basic guidelines on how she cleaned house. All this because a utility truck pulled the service line in the alley behind her house in an accident with the truck being taller then the lines. It yanked stuff from the meter box and it took the landlord about a week to get someone licenses (as required by law) to repair and certify the service meter so the electric company could schedule an appointment and come out to reconnect service. The neighbor made a comment to someone else about how the kids must be roasting without being able to turn a fan on or the air conditioner and this goody goody person though calling DCS would speed the process up. Instead, it was treated as a complain for inhumane treatment which took her 2 toddlers away for two months and forced her into the court system to get them back. I ended up contributing to her legal fees (there was about 7 of us that paid her legal fees to help her out)

    You would really be surprised at how little it takes to get them involved and how hard it is to get them out.

    WRT to consumers being informed, I stand by my statements. Real choice is necessary, but no more or less so than informed consumers. You can't maximise value if you have no way to determine value in the first place. Poorly informed buying leads to mal-investment in cheap shoddy goods rather than the ones that cost twice as much and return 4 times the value.

    Informed decisions is only part of choice. Choice can happen without it or you can become informed along the way. Let me tell you yet another story. At a place I used to work, they would cut us a $30 or $40 check twice a year for a work boot allowance because we needed steel towed boots. I used to go buy the cheapest ones I could find and pocket 5 to 10 bucks. After talking about my feet hurting, a coworker told me he never has that problem but he kicked in about $50 to buy his boots. I decided to buy a pair and give them a try. These are Rocky Boots and while I haven't purchased a pair in over 15 years, I would still run for them if I needed another pair. But not only did I find that my feet didn't hurt after long shifts, they lasted a little over a year. So I would buy one pair a year with my own money, use the old pair for stuff around the house or going into the woods when it is muddy out and I would just pocket the boot allowances when they came. In the end, I think I was only out $10 or $20 over what the company gave us. After I stopped working there, I purchased one other pair which has lasted m

  61. Re: Prescription drug prices by sjames · · Score: 1

    I wasn't educated on their products at all, I made a choice at the recommendation of someone I worked with and found the differences in the quality and costs soon after.

    What we have here is a terminology problem. Initially, your boot choice was uninformed, then your friend informed you and you made a better choice.

    If by elasticity, you meaning all the fluff in the layers above, then you might be right

    More terminology. The fluff is the elastic part. Your demand will stretch and contract based on your income, market prices and your valuation of the product. The hardcore parts you can't do without are the inelastic parts. You will be in that market even if the prices are unreasonable and the value is poor.

    As far as DFACS goes, I don't have kids, but I have certainly heard more than enough credible horror stories. As far as I can see, they are primarily in the business of yanking kids out of loving homes suffering minor setbacks or simply a few degrees off from cultural norms and stuffing them into stranger's homes where standards are even worse. Occasionally they may accidentally improve the child's quality of life.

    Being informed isn't literally essential to choice. One can always flip a coin or otherwise choose blindly. However, that sort of choice does not 'drive the invisible hand' of the market towards better value and more efficiency at all. Back to your story, when you made the uninformed choice, you placed your economic support behind the maker of a poor quality product that ultimately wasn't worth the price they charged. When your choice became informed, you switched your economic support to a manufacturer that made a better value trade-off between price and performance. As a result, they were rewarded for making the better choice, your quality of life went up, and you likely became a more productive worker.

    Expanding your individual situation to the market for work boots, if everyone made the uninformed choice the superior producer would have been forced towards the bad price/performance tradeoff or out of the market. OTOH if everyone makes the informed choice, the poor quality producer is forced to make better choices as well or exit the market giving someone smarter a shot at it. In the event that there is no choice, demand elasticity is what allows consumers to either leave the market or participate to a minimal degree. The resulting untapped demand in turn provides incentive for a (hopefully better) supplier to enter the market and restore choice. Where the market is wholly inelastic and choice is essentially random, there is no incentive to improve quality or reduce price. For those reasons, a healthy capitalist economy requires elasticity and informed consumers.

  62. Re: Prescription drug prices by sumdumass · · Score: 1

    What we have here is a terminology problem. Initially, your boot choice was uninformed, then your friend informed you and you made a better choice.

    But you see, I wasn't fully informed until after owning the boots for a little over a year. I don't think capitalism suffered. And besides, the old boots were adequate if you didn't wear them for long periods of time and perhaps only needed to used them occasionally instead of every workday. Sure becoming informed helped me make a choice but it wasn't deterministic to having that choice.

    More terminology. The fluff is the elastic part. Your demand will stretch and contract based on your income, market prices and your valuation of the product. The hardcore parts you can't do without are the inelastic parts. You will be in that market even if the prices are unreasonable and the value is poor.

    Then I think we are talking about two separate ends of the spectrum here. I am assuming that life saving health care weeded out all the non-life-threatening portions of health care like getting doctors excuses to miss work, stuff to help get through a cold, and so on. This is why I stripped off the joy riding and quality of life stuff from the others examples being tossed around when doing my considerations. And in that respect, you are probably right but that should undermine the fact that below all the quality of life stuff, there is a basic need just as important as life saving medical care.

    As far as DFACS goes, I don't have kids, but I have certainly heard more than enough credible horror stories. As far as I can see, they are primarily in the business of yanking kids out of loving homes suffering minor setbacks or simply a few degrees off from cultural norms and stuffing them into stranger's homes where standards are even worse. Occasionally they may accidentally improve the child's quality of life.

    and that is putting it lightly. I would have more respect for them if they appeared to have some common sense in their actions but that seems to be asking too much.

    Being informed isn't literally essential to choice. One can always flip a coin or otherwise choose blindly. However, that sort of choice does not 'drive the invisible hand' of the market towards better value and more efficiency at all. Back to your story, when you made the uninformed choice, you placed your economic support behind the maker of a poor quality product that ultimately wasn't worth the price they charged. When your choice became informed, you switched your economic support to a manufacturer that made a better value trade-off between price and performance. As a result, they were rewarded for making the better choice, your quality of life went up, and you likely became a more productive worker.

    But you see, people have this ability, even though they attempt to suppress it, but they have the ability to learn from their experiences. The invisible hand of the market is a result of this. And more to the boot point, the old boots wouldn't be bad for occasional use or use in a way that was different then I used them. They would be fine for someone who doesn't need to spend 8-10 in them 5 or 6 days a week. You see, capitalism isn't always about always getting the very best product for the very best value. It is about having the choices available so you can match the products to your needs. And if something doesn't fit your needs, someone else can step in to do so. SO yea, while I ultimately found a better deal, having the old choice of boots available for others who's needs aren't the same as mine if a key to capitalism.

    Expanding your individual situation to the market for work boots, if everyone made the uninformed choice the superior producer would have been forced towards the bad price/performance tradeoff or out of the market. OTOH if everyone makes the informed choice, the poor quality producer is forced to mak