Always better to read the actual research paper.
You might also have a cancer cell that's fixed by the Mismatch Repair mechanism. Do this report cancer in the case where cells can be repaired?
Some cancers have markers on the cell surface and immunotherapy exploits these markers to go after just cancer cells. But some mutations like KRAS, NRAS, HRAS, the so-called undruggables, don't have markers on the cell surface that we currently know of. There has been some remarkable work at NCI, particularly with KRAS G12D and KRAS G12V, that present markers on the cell surface with certain alleles and this has led to a few immunotherapy cures. But this stuff is in its infancy.
There are some 39 or so cancers and hundreds of gene mutations. Does this test cover all of those? I would be skeptical that it covers everything.
My last three care were Toyotas. The first I traded in with 250K miles - it still ran fine. The other two I still have, one with 100K and the other with 8K. I've taken the factory tour and there were a lot of US employees working seemingly happily there. I would be happy to buy a Ford or GM if they were as reliable as the Toyotas are.
Housing values at the high-end are already suffering in some cities and I'd agree that higher interest rates will help.
There are lots of places where property isn't expensive but they aren't hubs. Many could live there - the folks that can work remotely - if broadband is good.
I wasn't able to exercise much for over a year though I walked 900 miles this summer. The problem with this kind of exercise was the lack of intensity (I ran, lifted and played tennis before being forced to take time off). I had a cardiac event which was caused by dehydration and saw a cardiologist and he suggested some intensity. I bought a Fenix 5+ and it showed that my while driving or working between 80 and 100. A few weeks of running got it down between 70-80. The running dropped my stress scores as well. The health tracking tech is really great stuff for looking at metrics which affect heart health, stress, sleep, etc.
The rumors come out every year.
I have my eye on the 32 GB Core i9 MacBook Pro.
Where's the ARM equivalent? Can it run Solaris, Linux, Windows?
The margins have to be great for the 8th gen i7 and i9 models.
I upgraded to 11.4 a while ago and didn't see any problems. What I usually see is articles saying that battery life is better for some and worse for others. I'd guess that it's App issues.
Best bang for your buck depends on what you do. My total bill last month was $7.44 for four phones or less than $2/phone/month and this on Verizon's network.
Both are deal-killers for me. I have a 2014 MBP and it's fine but Apple would have to fix these two issues for me to upgrade. I just bought a 1 TB SSD and 4 GB of RAM to add to an old 17 inch 2008 MBP - better keyboard than everything that has come after. I usually hook up a mechanical keyboard with Cherry MX Blues to my systems and only use the built-in keyboard when I'm at a coffee shop or otherwise mobile. So Apple: 1) fix the keyboards, 2) fix the video, 3) update the Mini, 4) Update the Pro. Give a little love to your Macs.
The known problems are the keyboards and video artifacts problem. A co-worker got a new 13 inch 2017 MBP and it had video artifacts within a few months. He brought it to the Apple Store and they fixed it for him. I have a 2014 15 MBP (personal) and a Corporate 2015 13 MBP. They both work great. The keyboards work and they just plain work overall. But I wouldn't touch the 2016 and 2017 stuff and Apple must know this. I use my MBP at a desk the vast majority of the time and have it hooked up to KVMM. The keyboards are mechanical, and very clicky and noisy, just the way I like them. Lots of key travel too. Apple should make models with more keyboard travel and sell them as gaming models.
They did that thing in Windows 8.1 and I spend a day getting rid of it (I didn't know how to bypass it in the installation). My system is usually down for a day on major Windows 10 upgrades. Fortunately my main system is a Mac. And I usually wait a few months before doing updates.
I got upgraded from 25 to 60 in March I think. Doesn't really matter - I think that 25 is probably more than we need. I have internet-only. This policy is new I guess.
It's nice though fairly inexpensive. Homes run around $180K. They put the wiring underground as we have winter storms that can take down lines regularly.
I have a two-year contract right now. But there's only a year left on it. A friend did the same thing (I told him about it) and he was up this year and they jacked his price up to the retail price. He called, gave them hell and they gave him his old price for another two years. He has Consolidated Communications Fiber as an option in his city.
I don't think that I'd move to a place that didn't have realistic broadband as my workplace has the expectation that you may get called at any time to work on something.
Boston has Comcast, Verizon and RCN and my neighborhood has Comcast, Consolidated and DirectTV as providers. So you can have choice in cities. Comcast is very good at playing the political game. They provide lower rates for low-income folks, and do good works in big cities and I assume that the Mayor gets some credit and photo ops with those. Our situation is much improved with three realistic options. I really want Comcast service but competition helps in negotiations.
$50 for 60/5 and Xfinity Wifi (18 million hotspots). Retail rate is $80. $100+ is theft. I can't believe those rates.
My son had a place in Boston several years ago and I tried to negotiate with Comcast for him. Boston has Comcast, Verizon DSL and RCN (cable). I looked up RCN and it appears that they have even more customer complaints than Comcast. So I called them up and tried to negotiate and said that he'd move to RCN and their response was: go ahead. The cable companies know their local markets really, really well and only negotiate when they think you're really going to drop them. If I had two expensive choices, I'd do the old long-distance phone thing from the 1990s and just switch service back and forth to get the promotional offers - or just threaten to do that.
We have 2 Gbps service available for $300/month. 1 Gbps is $104/month. The installation fee for 2 Gbps is $500. The installation fee for all of their other tiers is "up to $500". There is also an activation fee of $500 for 2 Gbps. BTW, I'm fine with 20 or 25 Mbps.
If they raise rates high enough, then competition shows up, at least in metro areas. Folks in rural areas generally get a raw deal with only one realistic provider. And I don't consider 1.5 Mbps DSL realistic service.
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Always better to read the actual research paper. You might also have a cancer cell that's fixed by the Mismatch Repair mechanism. Do this report cancer in the case where cells can be repaired?
Some cancers have markers on the cell surface and immunotherapy exploits these markers to go after just cancer cells. But some mutations like KRAS, NRAS, HRAS, the so-called undruggables, don't have markers on the cell surface that we currently know of. There has been some remarkable work at NCI, particularly with KRAS G12D and KRAS G12V, that present markers on the cell surface with certain alleles and this has led to a few immunotherapy cures. But this stuff is in its infancy. There are some 39 or so cancers and hundreds of gene mutations. Does this test cover all of those? I would be skeptical that it covers everything.
DNA in solid tumors may not migrate into the bloodstream (you actually don't want this as this is how cancer spreads).
My last three care were Toyotas. The first I traded in with 250K miles - it still ran fine. The other two I still have, one with 100K and the other with 8K. I've taken the factory tour and there were a lot of US employees working seemingly happily there. I would be happy to buy a Ford or GM if they were as reliable as the Toyotas are.
I'm sadistic - I like assembler.
Housing values at the high-end are already suffering in some cities and I'd agree that higher interest rates will help. There are lots of places where property isn't expensive but they aren't hubs. Many could live there - the folks that can work remotely - if broadband is good.
I wasn't able to exercise much for over a year though I walked 900 miles this summer. The problem with this kind of exercise was the lack of intensity (I ran, lifted and played tennis before being forced to take time off). I had a cardiac event which was caused by dehydration and saw a cardiologist and he suggested some intensity. I bought a Fenix 5+ and it showed that my while driving or working between 80 and 100. A few weeks of running got it down between 70-80. The running dropped my stress scores as well. The health tracking tech is really great stuff for looking at metrics which affect heart health, stress, sleep, etc.
There's the VAT in Canada. We have a lot of Canadian shoppers coming down to our malls in my state. Had a ton of them vacationing here too.
The rumors come out every year. I have my eye on the 32 GB Core i9 MacBook Pro. Where's the ARM equivalent? Can it run Solaris, Linux, Windows? The margins have to be great for the 8th gen i7 and i9 models.
I upgraded to 11.4 a while ago and didn't see any problems. What I usually see is articles saying that battery life is better for some and worse for others. I'd guess that it's App issues.
Yup. The people that run companies don't want their own offices to be open either.
Best bang for your buck depends on what you do. My total bill last month was $7.44 for four phones or less than $2/phone/month and this on Verizon's network.
Both are deal-killers for me. I have a 2014 MBP and it's fine but Apple would have to fix these two issues for me to upgrade. I just bought a 1 TB SSD and 4 GB of RAM to add to an old 17 inch 2008 MBP - better keyboard than everything that has come after. I usually hook up a mechanical keyboard with Cherry MX Blues to my systems and only use the built-in keyboard when I'm at a coffee shop or otherwise mobile. So Apple: 1) fix the keyboards, 2) fix the video, 3) update the Mini, 4) Update the Pro. Give a little love to your Macs.
Do they have a recovery plan?
The known problems are the keyboards and video artifacts problem. A co-worker got a new 13 inch 2017 MBP and it had video artifacts within a few months. He brought it to the Apple Store and they fixed it for him. I have a 2014 15 MBP (personal) and a Corporate 2015 13 MBP. They both work great. The keyboards work and they just plain work overall. But I wouldn't touch the 2016 and 2017 stuff and Apple must know this. I use my MBP at a desk the vast majority of the time and have it hooked up to KVMM. The keyboards are mechanical, and very clicky and noisy, just the way I like them. Lots of key travel too. Apple should make models with more keyboard travel and sell them as gaming models.
They did that thing in Windows 8.1 and I spend a day getting rid of it (I didn't know how to bypass it in the installation). My system is usually down for a day on major Windows 10 upgrades. Fortunately my main system is a Mac. And I usually wait a few months before doing updates.
Windows 10 to be specific. I upgraded three machines from Windows 7 and do regret it.
I got upgraded from 25 to 60 in March I think. Doesn't really matter - I think that 25 is probably more than we need. I have internet-only. This policy is new I guess.
It's nice though fairly inexpensive. Homes run around $180K. They put the wiring underground as we have winter storms that can take down lines regularly.
I have a two-year contract right now. But there's only a year left on it. A friend did the same thing (I told him about it) and he was up this year and they jacked his price up to the retail price. He called, gave them hell and they gave him his old price for another two years. He has Consolidated Communications Fiber as an option in his city.
I don't think that I'd move to a place that didn't have realistic broadband as my workplace has the expectation that you may get called at any time to work on something.
Boston has Comcast, Verizon and RCN and my neighborhood has Comcast, Consolidated and DirectTV as providers. So you can have choice in cities. Comcast is very good at playing the political game. They provide lower rates for low-income folks, and do good works in big cities and I assume that the Mayor gets some credit and photo ops with those. Our situation is much improved with three realistic options. I really want Comcast service but competition helps in negotiations.
$50 for 60/5 and Xfinity Wifi (18 million hotspots). Retail rate is $80. $100+ is theft. I can't believe those rates. My son had a place in Boston several years ago and I tried to negotiate with Comcast for him. Boston has Comcast, Verizon DSL and RCN (cable). I looked up RCN and it appears that they have even more customer complaints than Comcast. So I called them up and tried to negotiate and said that he'd move to RCN and their response was: go ahead. The cable companies know their local markets really, really well and only negotiate when they think you're really going to drop them. If I had two expensive choices, I'd do the old long-distance phone thing from the 1990s and just switch service back and forth to get the promotional offers - or just threaten to do that. We have 2 Gbps service available for $300/month. 1 Gbps is $104/month. The installation fee for 2 Gbps is $500. The installation fee for all of their other tiers is "up to $500". There is also an activation fee of $500 for 2 Gbps. BTW, I'm fine with 20 or 25 Mbps.
If they raise rates high enough, then competition shows up, at least in metro areas. Folks in rural areas generally get a raw deal with only one realistic provider. And I don't consider 1.5 Mbps DSL realistic service.
Comcast's MVNO service is great. My latest bill was $8.44 for four lines. So $2.11 per line.