Ann Landers wrote a column lobbying for increased funding for cancer research. (https://www.huffingtonpost.com/olivia-katrandjian/retro-report-nixon-cancer_b_4182302.html) Richard Nixon signed the bill and we poured a huge amount of money into cancer research. Yet most of the progress we have made has been the result of prevention and early detection. What did we really get from that money
At the time, not much. One of the few novel scientific discoveries coming from Nixon's War on Cancer, was the existence of previously unknown class of viruses associated with some uncommon forms of human leukemia. This novel class of virus was the called the "Retroviruses" for their unusual RNA-to-DNA reverse transcription mechanism used as part of their life cycle.
Usually at these levels people are forbidden from working for a direct competitor for up to 5 years. Possibly AMD agreed not to sue Intel for poaching in exchange for Intel using AMD graphics chips in their APUs.
Non-compete agreements are generally not enforceable in California. Both Intel and AMD's headquarters are in California, and Raja apparently lives there as well.
This is what Waifu2x does, for the limited case of anime-based images. It is a neural network based upscaler capable of doing some very good enlargements on comic-like and cartoon-like images.
Although Amazon has stated that they plan to establish a "2nd" HQ that is to be equal to their first, I have to wonder if the motivation is to set up an alternative location that could eventually surpass Seattle and become the primary HQ. It's apparent that there is growing resentment over Amazon's impact on the city, and maybe Amazon is planning ahead for a day when the local political environment is too hostile to support its continued growth.
If that happens, the locals anti-Amazon crowd may end up pondering the wisdom of being careful what you wish for.
I am not a surgeon, but I am a doctor who recently finished residency. Testing for recent smoking is a very good policy, and it will save lives and reduce complications, as smoking interferes with recovery from surgery like you wouldn't believe. Even if a patient can't stop smoking long term, they need to at least stop for a few weeks (preferably for at least a few weeks before and a few weeks after surgery).
Cigarettes are a vasoconstrictor, meaning they cause blood vessels to clamp down, reducing blood flow. It contains carbon monoxide, which reduces oxygen carrying capacity. It suppresses the immune system -- all this interferes with wound healing, and the post-surgical period is often a race between wound-healing and breakdown/infection. Patients literally can have poorly healing surgical sites split wide open or bits of themselves turn black and necrotic, because they couldn't stop smoking at least temporarily.
Smoking is pro-coagulant, increasing tendency of blood to clot -- this is not a good thing, as it tends to do so in all the wrong places at the wrong times, and a major potential complication with bed-bound patients and patients recovering from surgery can be abnormal blood clots in the veins and lungs. It paralyzes the respiratory cilia that clean your airways, and it reduces lung function, at a time when a patient is at elevated risk for pneumonia.
You want to keep smoking after you're all done healing up? Fine, we'll tut-tut at you about the long-term risks when you're following-up in the outpatient office later, but stopping around the time of surgery can literally be a matter of life or death.
He's absolutely right about it being a "collection of standards", where it's unclear whether a USB-C receptacle is power-only, high-power, power+data...etc. That inconsistency is hindrance to adoption, rather than flexibility.
There needs to be some kind of mandatory icon set next to the USB logo, to indicate what modes a device's USB-C ports support. Maybe with arrows pointing to/from the icon to indicate which way the support goes.
The Boeing 787 and Airbus A350 supposedly feature improvements in cabin air pressure, with pressurization to 6000 feet equivalent, as well as increases in humidity.
Perhaps certain bacteria in the body prefer tumours over normal tissue.
Many successful cancers are now known to have immune-suppressing features -- a major focus of research now involved "Checkpoint Inhibitors" such as PD-1 which interfere with these suppression mechanisms. The bacteria would probably otherwise would be involved in a raging immune battle, if not for the local down-regulation.
Such a poor defense strategy suggests Comcast doesn't intend to win this court case. Rather, they probably intend to tie up things in legal proceedings for a good long while.
I'd check the contract carefully to see if there is any sort of clock they can run out by delaying this implementation, or some elected or appointed official's term expiry coming up.
Businesses wanting to make profit will do so at all costs.
This is what scares me. No super-intelligence cogito-ergo-sum AI is required, all that is needed is merely the currently existing elite ranks of humans employing banks of somewhat-clever machines only modestly more advanced than what we have. No Terminators mowing us down with plasma rifles, just the gradual optimizing-away of human agency and happiness, until society collapses.
The much "coveted" technology, if it works, would bring diesel engine efficiency to gasoline engines. That is all.
Mazda's presentation also had an example output curve for their SkyActiv-X engine, apparently it also produces diesel-like torque as well. It also does quite well with low-octane gasoline, as octane rating is irrelevant to a compression-ignition engine.
There was only one bank which ended up getting prosecuted for the '08 mortgage crisis. A tiny Chinatown family-owned bank that discovered one of their loan officers taking bribes and making fraudulent mortgage applications. The managers of the bank promptly reported him to regulators -- for which the managers were indicted, with the fraudulent loan officer becoming the star witness for the prosecution against the bank.
http://www.npr.org/2017/05/18/... "As it happens, Abacus didn't deal in subprime. The Chinatown-based bank also didn't package its mortgages into the sort of financial instruments that made The Big Short's machinations so arcane. In fact, the bank had one of the lowest default rates in the country."
you'll certainly gain access to these advanced new antibiotics as well...at $30,000 a bottle.
One of the last major antibiotic innovations though the pipeline was daptomycin, approved in the 1980's. Not sure what it costs now, but a few years ago a course of IV daptomycin was $28k.
Another thing to keep in mind is that a chart is not some purely dispassionate recording of standardized metrics. Even before you get to the diagnosis, you are already looking at pre-processed information, and not raw data.
Although there are some parameters recorded for most patients regardless of the issues at hand (such as vital signs, or maybe listening to the patient's heart/lungs), other history and data is selected -- much of the history, review of systems, and physical exam is performed as a way of supporting or excluding items in a differential that the physician is already thinking about. The list of things that I could observe and write down about a human in a chart is practically unlimited, including a long and useless lists of things that patient doesn't have -- and if I choose to specifically mention what findings are absent, it is because I am making a case for one condition or another..
The other thing to consider is that part of the evidence that is used to support or refute a diagnosis is time. Often I ask a patient to follow-up over the next few days, weeks or months as a way to see if things change (or don't change) the way I expect it too. When a patient follows up with me, I may be making a "second opinion" each time, and the ability to follow someone over time is a valuable tool that gets discarded when someone bounces from doctor-to-doctor searching for answers, without ever looping back to previously visited doctors for follow-up. Sometimes there is a list of rare "zebra" diagnosis that I usually don't write down, because I would usually get laughed at by colleagues for jumping at shadows (but I may keep them in mind if things start not making sense in the future). In any case, a doctor who is asked for a second opinion gets the luxury of having both the first doctor's records (hopefully), as well as a data point occurring later in time.
Anyway, can the thought process for making a final analysis of the case a doctor has made from examining a patient be improved? Certainly, but keep in mind Garbage-In, Garbage-Out, if you feed the AI medical records from someone with excellent vs poor clinical diagnosis skills, the quality of your results will vary greatly. Presumably the best results would be obtained when applied to a doctor with good intuition and observation skills, but poorly organized decision making.
All I know is the Bay Area Newsgroup reported that a Silicon Valley engineer ultimately earns more over their lifetime than the average NFL football player.
Reminds me of an article comparing a doctor's lifetime earnings vs a UPS driver. In the analysis, the doctor doesn't pull ahead until about 18 years after high school, due to the long period of schooling and residency, plus debt load.
Or we could end up like the soldier character Amanda Bates in Peter Watt's Blindsight, a human inserted into a network of AI driven machines, each quicker and more lethal than her fragile human self. Yet she has the final say and utmost authority over the decision to kill.
The unfortunate implication? Her AI team becomes far more dangerous once the slow-thinking and squishy human dies, and they get let off the leash. Meaning that she has as much to fear from her superiors as from her enemies.
Roger Walkden, Senior Director and Commercial Lead of HoloLens, acknowledged that the price tag was partly responsible for the small number of sales.
Up until fairly recently, most news about the HoloLens seemed to present it as some sort of far-off research project, with little hope of a commercial product you could actually ever buy. That impression has probably contributed to a lack of hype and development of third-part applications, too.
The $10 Quadrillion figure is total baloney. You can't just take the current value and extrapolate, because the price would fall as the supply rises. A one carat diamond may be worth $10,000, but if there were suddenly a trillion of them, they would be worth next to nothing, and people would use them as gravel in their driveways.
The $10 Quadrillion figure is also a pretty good signal that the current market is unable to respond adequately to meet demand, no? Let somebody satiate that unsatisfied demand, and see what humanity does with it. Certainly that will mean the collapse and disappearance of some current mining industries, but it could also mean the emergence of completely unexpected industries on the demand side of things.
Let's hope Google has had the forethought to have the image recognition algorithm pre-screen for images containing numbers, letters, and diagrams. Pattern-matching compression can be pretty scary when it decides two patterns are close enough:
Pleconaril (Picovir) failed FDA trials, but not necessarily for the reasons you might think at first glance. The problem is that the FDA considers common colds to be a trivial health issue for the general public, with very low mortality. Easily treatable with supportive care. However, the segment of the population that might take this drug is very, very large (most of the population). As a result, the FDA will demand perfection from any clinical trials, with the bar set at an impossible to meet standard. Back when this drug was in development, I knew this is exactly what would happen -- the moment Viropharma decided to go after the Common Cold patient population, I knew it was doomed.
The only way something like this could ever pass, is if they defined the drug's indications to be a more dangerous member of the Picornavirus, affecting a much smaller population. Like Enterovirus D68 post-exposure prophylaxis in a child, Poliovirus post-exposure prophylaxis in a non-immune patient, or something like Fulminant Hepatitis A or post-exposure prophyaxis in a non-immunized patient. They didn't understand the politics of drug approval, and so they got squashed. And so it is too late now.
Slashdot Mirror
Ann Landers wrote a column lobbying for increased funding for cancer research. (https://www.huffingtonpost.com/olivia-katrandjian/retro-report-nixon-cancer_b_4182302.html) Richard Nixon signed the bill and we poured a huge amount of money into cancer research. Yet most of the progress we have made has been the result of prevention and early detection. What did we really get from that money
At the time, not much. One of the few novel scientific discoveries coming from Nixon's War on Cancer, was the existence of previously unknown class of viruses associated with some uncommon forms of human leukemia. This novel class of virus was the called the "Retroviruses" for their unusual RNA-to-DNA reverse transcription mechanism used as part of their life cycle.
At the time not considered to be of any major clinical significance in human disease, although this opinion would later be revised.
Always remember: Ceiling Cat is watching you masturbate.
TFA merely raises some interesting speculations, regarding the true nature of Ceiling Cat. But his purpose in this universe remains unchanged.
Non-compete agreements are generally not enforceable in California. Both Intel and AMD's headquarters are in California, and Raja apparently lives there as well.
This is what Waifu2x does, for the limited case of anime-based images. It is a neural network based upscaler capable of doing some very good enlargements on comic-like and cartoon-like images.
http://waifu2x.udp.jp/
Although Amazon has stated that they plan to establish a "2nd" HQ that is to be equal to their first, I have to wonder if the motivation is to set up an alternative location that could eventually surpass Seattle and become the primary HQ. It's apparent that there is growing resentment over Amazon's impact on the city, and maybe Amazon is planning ahead for a day when the local political environment is too hostile to support its continued growth.
If that happens, the locals anti-Amazon crowd may end up pondering the wisdom of being careful what you wish for.
I am not a surgeon, but I am a doctor who recently finished residency. Testing for recent smoking is a very good policy, and it will save lives and reduce complications, as smoking interferes with recovery from surgery like you wouldn't believe. Even if a patient can't stop smoking long term, they need to at least stop for a few weeks (preferably for at least a few weeks before and a few weeks after surgery).
Cigarettes are a vasoconstrictor, meaning they cause blood vessels to clamp down, reducing blood flow. It contains carbon monoxide, which reduces oxygen carrying capacity. It suppresses the immune system -- all this interferes with wound healing, and the post-surgical period is often a race between wound-healing and breakdown/infection. Patients literally can have poorly healing surgical sites split wide open or bits of themselves turn black and necrotic, because they couldn't stop smoking at least temporarily.
Smoking is pro-coagulant, increasing tendency of blood to clot -- this is not a good thing, as it tends to do so in all the wrong places at the wrong times, and a major potential complication with bed-bound patients and patients recovering from surgery can be abnormal blood clots in the veins and lungs. It paralyzes the respiratory cilia that clean your airways, and it reduces lung function, at a time when a patient is at elevated risk for pneumonia.
You want to keep smoking after you're all done healing up? Fine, we'll tut-tut at you about the long-term risks when you're following-up in the outpatient office later, but stopping around the time of surgery can literally be a matter of life or death.
He's absolutely right about it being a "collection of standards", where it's unclear whether a USB-C receptacle is power-only, high-power, power+data...etc. That inconsistency is hindrance to adoption, rather than flexibility.
There needs to be some kind of mandatory icon set next to the USB logo, to indicate what modes a device's USB-C ports support. Maybe with arrows pointing to/from the icon to indicate which way the support goes.
The Boeing 787 and Airbus A350 supposedly feature improvements in cabin air pressure, with pressurization to 6000 feet equivalent, as well as increases in humidity.
Unfortunately, they still aren't that common.
Perhaps certain bacteria in the body prefer tumours over normal tissue.
Many successful cancers are now known to have immune-suppressing features -- a major focus of research now involved "Checkpoint Inhibitors" such as PD-1 which interfere with these suppression mechanisms. The bacteria would probably otherwise would be involved in a raging immune battle, if not for the local down-regulation.
Such a poor defense strategy suggests Comcast doesn't intend to win this court case. Rather, they probably intend to tie up things in legal proceedings for a good long while.
I'd check the contract carefully to see if there is any sort of clock they can run out by delaying this implementation, or some elected or appointed official's term expiry coming up.
Businesses wanting to make profit will do so at all costs.
This is what scares me. No super-intelligence cogito-ergo-sum AI is required, all that is needed is merely the currently existing elite ranks of humans employing banks of somewhat-clever machines only modestly more advanced than what we have. No Terminators mowing us down with plasma rifles, just the gradual optimizing-away of human agency and happiness, until society collapses.
The much "coveted" technology, if it works, would bring diesel engine efficiency to gasoline engines. That is all.
Mazda's presentation also had an example output curve for their SkyActiv-X engine, apparently it also produces diesel-like torque as well. It also does quite well with low-octane gasoline, as octane rating is irrelevant to a compression-ignition engine.
Those guys never do time
There was only one bank which ended up getting prosecuted for the '08 mortgage crisis. A tiny Chinatown family-owned bank that discovered one of their loan officers taking bribes and making fraudulent mortgage applications. The managers of the bank promptly reported him to regulators -- for which the managers were indicted, with the fraudulent loan officer becoming the star witness for the prosecution against the bank.
http://www.npr.org/2017/05/18/...
"As it happens, Abacus didn't deal in subprime. The Chinatown-based bank also didn't package its mortgages into the sort of financial instruments that made The Big Short's machinations so arcane. In fact, the bank had one of the lowest default rates in the country."
Some other articles on the prosecution of Abacus:
https://www.nytimes.com/2015/0...
https://www.washingtonpost.com...
https://www.nytimes.com/2015/1...
I know an Osteopathic Physician named Dr. Abend, any chance you are related?
I'd be interested to know if MVNOs / GoogleFi will get access to this new 600MHz spectrum, once the phone support rolls out.
Ironically that is something that Hollywood are imposing on themself
Wow, it's almost as if they have to obey some invisible hand, or some evolutionary economic selection process.
you'll certainly gain access to these advanced new antibiotics as well...at $30,000 a bottle.
One of the last major antibiotic innovations though the pipeline was daptomycin, approved in the 1980's. Not sure what it costs now, but a few years ago a course of IV daptomycin was $28k.
Another thing to keep in mind is that a chart is not some purely dispassionate recording of standardized metrics. Even before you get to the diagnosis, you are already looking at pre-processed information, and not raw data.
Although there are some parameters recorded for most patients regardless of the issues at hand (such as vital signs, or maybe listening to the patient's heart/lungs), other history and data is selected -- much of the history, review of systems, and physical exam is performed as a way of supporting or excluding items in a differential that the physician is already thinking about. The list of things that I could observe and write down about a human in a chart is practically unlimited, including a long and useless lists of things that patient doesn't have -- and if I choose to specifically mention what findings are absent, it is because I am making a case for one condition or another..
The other thing to consider is that part of the evidence that is used to support or refute a diagnosis is time. Often I ask a patient to follow-up over the next few days, weeks or months as a way to see if things change (or don't change) the way I expect it too. When a patient follows up with me, I may be making a "second opinion" each time, and the ability to follow someone over time is a valuable tool that gets discarded when someone bounces from doctor-to-doctor searching for answers, without ever looping back to previously visited doctors for follow-up. Sometimes there is a list of rare "zebra" diagnosis that I usually don't write down, because I would usually get laughed at by colleagues for jumping at shadows (but I may keep them in mind if things start not making sense in the future). In any case, a doctor who is asked for a second opinion gets the luxury of having both the first doctor's records (hopefully), as well as a data point occurring later in time.
Anyway, can the thought process for making a final analysis of the case a doctor has made from examining a patient be improved? Certainly, but keep in mind Garbage-In, Garbage-Out, if you feed the AI medical records from someone with excellent vs poor clinical diagnosis skills, the quality of your results will vary greatly. Presumably the best results would be obtained when applied to a doctor with good intuition and observation skills, but poorly organized decision making.
If you're sending your tax returns on the day of the deadline and want proof you did your part on time, you send it registered mail.
A Certificate of Mailing is adequate for proof as far as the IRS is concerned, and costs a fraction of what they charge for Registered mail.
All I know is the Bay Area Newsgroup reported that a Silicon Valley engineer ultimately earns more over their lifetime than the average NFL football player.
Reminds me of an article comparing a doctor's lifetime earnings vs a UPS driver. In the analysis, the doctor doesn't pull ahead until about 18 years after high school, due to the long period of schooling and residency, plus debt load.
http://www.er-doctor.com/docto...
Or we could end up like the soldier character Amanda Bates in Peter Watt's Blindsight, a human inserted into a network of AI driven machines, each quicker and more lethal than her fragile human self. Yet she has the final say and utmost authority over the decision to kill.
The unfortunate implication? Her AI team becomes far more dangerous once the slow-thinking and squishy human dies, and they get let off the leash. Meaning that she has as much to fear from her superiors as from her enemies.
Roger Walkden, Senior Director and Commercial Lead of HoloLens, acknowledged that the price tag was partly responsible for the small number of sales.
Up until fairly recently, most news about the HoloLens seemed to present it as some sort of far-off research project, with little hope of a commercial product you could actually ever buy. That impression has probably contributed to a lack of hype and development of third-part applications, too.
The $10 Quadrillion figure is total baloney. You can't just take the current value and extrapolate, because the price would fall as the supply rises. A one carat diamond may be worth $10,000, but if there were suddenly a trillion of them, they would be worth next to nothing, and people would use them as gravel in their driveways.
The $10 Quadrillion figure is also a pretty good signal that the current market is unable to respond adequately to meet demand, no? Let somebody satiate that unsatisfied demand, and see what humanity does with it. Certainly that will mean the collapse and disappearance of some current mining industries, but it could also mean the emergence of completely unexpected industries on the demand side of things.
Let's hope Google has had the forethought to have the image recognition algorithm pre-screen for images containing numbers, letters, and diagrams. Pattern-matching compression can be pretty scary when it decides two patterns are close enough:
http://www.dkriesel.com/en/blo...
A drug called "Placonaril" by Viropharma.
Pleconaril (Picovir) failed FDA trials, but not necessarily for the reasons you might think at first glance. The problem is that the FDA considers common colds to be a trivial health issue for the general public, with very low mortality. Easily treatable with supportive care. However, the segment of the population that might take this drug is very, very large (most of the population). As a result, the FDA will demand perfection from any clinical trials, with the bar set at an impossible to meet standard. Back when this drug was in development, I knew this is exactly what would happen -- the moment Viropharma decided to go after the Common Cold patient population, I knew it was doomed.
The only way something like this could ever pass, is if they defined the drug's indications to be a more dangerous member of the Picornavirus, affecting a much smaller population. Like Enterovirus D68 post-exposure prophylaxis in a child, Poliovirus post-exposure prophylaxis in a non-immune patient, or something like Fulminant Hepatitis A or post-exposure prophyaxis in a non-immunized patient. They didn't understand the politics of drug approval, and so they got squashed. And so it is too late now.