That people have discovered that the intermediate step is also adjusted can hardly be called a shock.
Yes, it is a shock. The prevailing thought was that the RNA was transcribed faithfully and then that perfect transcript of the DNA was sliced up in strange ways. These people have discovered that the transcript may never have been perfect at all.
Imagine cutting up a loaf of bread: The geneticists were quibbling about how thick the slices were and how to arrange it on the plate, all without paying attention to what kind of bread they used. Now suddenly they've noticed that the recipe for french bread gave them a sourdough loaf while they aren't looking, and it may not be about the slicing as much as about how the right recipe is giving them the wrong thing to cut up.
The summary and the abstract really say almost nothing other than to confirm that the misspellings aren't random and don't seem like lab artifacts.
I'd be interested to know how conservative these mistakes tend to be. If the mistakes generally replace amino acids with very similar ones it might be a programmed method of prodding just how much variation a structure can take while remaining functional. Weird and random events, which can be only so weird and so frequent before everything breaks entirely, are necessary for evolutionary adaptation, and these weird protein errors might be a previously unknown mechanism of exploring slightly different structures for proteins and seeing how far an organism can push the envelope.
You can't legally patent something with 7 billion instances of prior art, nor should you be able to acquire a patent that all seven billion people in the world will involuntarily infringe ten million times a day.
Thank you, Justice Department, for another flash of the blindingly obvious.
Of course, if the DOJ has to spell this out, and the institutes that control our federal research dollars in health still can't see it, how does this bode for truly cooperative health research in the US? Not well, I'm guessing.
with a significantly larger kinetic energy than the LHC's beams.
It's hardly surprising or noteworthy that a hundred-ton train moving at 200 mph has more kinetic energy than a particle accelerator, because the accelerator manipulates extremely small masses and doesn't rely on kinetic energy to propel them. As far as I know the only kinetic energy involved is that of the tiny masses moving under magnetic propulsion and then crashing into things (or each other) at really high speed. So why is the above statement relevant or interesting in the least?
And it has made them the richest country in the world.
If I could quibble a bit here, I'm not sure they're actually the most wealthy nation in the world as measured by total assets, and I'm almost certain they're still on the lower half in terms of assets per person. Just because they're getting trillions in export sales and US debt payments doesn't mean they're particularly wealthy in any socially meaningful sense; there's 1.2 freaking billion of them to split that pie, and it's split even more unevenly than in the US. Only the upper class, as in top 20% or less, live as well as or better than Americans with the median income.
They may have a ridiculous pile of cash and a huge industrial machine, but it's not doing all that much for them so far.
They're only aware of a prior owner having registered the dog, and not necessarily of the fact that he was stolen. It's entirely possible and not improbable that they bought the dog from the thief, eventually decided they wanted him chipped, and view the whole matter as simply a need to update some records to reflect what they consider a legal change of ownership.
Nothing says or implies the new owners actually know he was stolen, and the company has probably declined to tell the new owners anything more than they've told Mr. Moorhouse, if the new owners even got enough information to become suspicious of any problems.
The state is best to enact this extremely modest tax increase
I agree that the rates are reasonable, but I wouldn't call 5% over 200k or 9% over 500k "extremely modest". Those are substantial percentages, especially considering Washington also has sales tax of ~8.8% depending on your location and that federal income tax also applies.
I agree with the tax, but it's bullshit to imply that rich people, at least those who don't dodge all their taxes, pay practically nothing.
Except that there would be other passengers there to spoil the view, and fuel. That would be weird.
I don't know how much other passengers would spoil the view, but I think fuel generally lives primarily in the wings, and jet-fuel kerosene is transparent in the first place.
So a wealthy company internationally famous for its creative and lavish benefits to employees, a company with a share price of $480, paid a total of $4,000 to outsiders who informed them of 10 major bugs in their software? They paid out $400 per bug?
The bounty for finding and documenting a bug in a Google product isn't even enough to buy one share of Google stock? That's downright insulting
Four sellers doesn't have to be an oligopoly, but that's how they've chosen to behave.
Actually, they do have to be an oligopoly. I can't remember the reference, but the book "Raising Less Corn, More Hell" included citations of an economist whose data suggested that when 4 or less competitors control 65% or more of a market they will automatically collude to control prices. Note that I say automatically and not [necessarily] intentionally; the source contended that market forces will affect each company such that, if profits are their main priority, then even without collusion they will effectively set prices and maintain them rather than compete on them. The source claimed the effect was so strong that they wouldn't undercut one another even if they didn't know each other *existed*. Markets with few sellers don't work out well for consumers, even when the sellers aren't money hungry pricks, and cell phone companies clearly are.
I think it's going to move Skype away from Consumers and into the Business world where the real money is.
Not necessarily. Cisco certainly does more business with the corporate world, but look at Linksys: WRT-54 routers have been the Cadillac of home and small enterprise wifi for a decade, and Linksys is nothing more or less than the consumer brand-name for Cisco.
If they treat Skype the way they treat Linksys, there's no reason to assume they'll do anything deleterious to private user's experience.
attaching the Internet Kill Switch bill as a rider
It's also possible that certain Senators are pretending to like this provision because they know its inclusion could kill the entire bill, a bill they despise secretly but cannot dislike openly. It's called a poison pill in parliamentary terms; an addition which, by design, makes a bill less attractive to its original supporters and may not be favored even of the person submitting it.
Pilot unions have objected to the collection and sharing of detailed accident data, citing privacy concerns of the flight crew.
I wasn't aware any reasonable expectation of privacy existed while working on a 4-8 person crew serving a couple hundred people in a space the size of a double-wide mobile home. Not to mention, just what other profession entitles you to privacy while at work, especially the sort of work where owners and direct supervisors are almost never in the same time zone as a given employee? They apparently feel entitled to privacy in a case where privacy would mean no oversight whatsoever.
Pilot unions have objected to the collection and sharing of detailed accident data, citing privacy concerns of the flight crew.
I wasn't aware any reasonable expectation of privacy existed while working on a 4-8 person crew serving a couple hundred people in a space the size of a double-wide mobile home. Not to mention, just what other profession entitles you to privacy while at work, especially the sort of work where owners and direct supervisors are almost never in the same time zone as a given employee? They apparently feel entitled to privacy in a case where privacy would mean no oversight whatsoever.
Well, it might suck, but presuming the legal basis of the court ruling is valid, I'm appreciative that they shut the experiments down.
Before you flame me into a crispy marshmallow, answer me this: Is the NIH the sort of institution you want playing fast and loose with any law or court ruling that isn't blatantly, obviously unconstitutional or an instantaneous danger to human lives? I want NIH crossing their T's and dotting the shit of out their I's, for my own safety and peace of mind, and while I hope they fight this ruling (because stem cells will save lives in the long run) I'm grimly satisfied they obeyed it while it's legally binding.
And there's that again. Not one single time in a decade on forums have I ever pointed out that people are assholes to conservatives and creationists without everyone instantly assuming I was one and merely pissed off about being personally attacked. I am not either, sir, I'm just tired of the stupid, preening self-righteousness that slashdot has in abundance. And your cute sarcastic response is, at very best, the pot calling the kettle black.
Whoever moderated such a statement "Informative" should be shot. It's nothing but a self-righteous, stereotyping flame, and everyone here knows it, but some genius feels the need to mod it "Informative" solely because it fits the typical vapid mockery of conservatives, creationists, and everyone else slashdotters feel empowered to judge.
To the few people here who apparently believe paranoid conservative conspiracy theorists vandalized Google to obscure the location of this rally: are you completely insane?
I mean, follow the bouncing ball: you're so paranoid that you'd like to hide the location of a giant rally by desecrating Google maps, but you've scheduled said rally at a landmark so famous tens of millions could find it with no maps at all? And how are fellow paranoid conservatives supposed to find said rally? Does Glenn Beck's web page include coded directions, decipherable only by clues so small you'd never notice them if you hadn't read Ronald Reagan's autobiography twelve times?
You may think Glenn Beck listeners somewhat clinically paranoid and/or politically foolish, but you don't look any smarter, more rational, or less paranoid in believing them both smart enough and rationally motivated to vandalize the map but otherwise too stupid to tie their own shoes.
Kudos to Garmin for proactively recalling their own unit before anybody dies or they have a growing public relations nightmare on their hands. It's much better stewardship of their brand and care for their customers than we ever see from car companies or medical device manufacturers.
Of course, it's also disheartening that the appropriate minimum response to discovering a serious flaw in one's product now feels extraordinary and laudable when viewed in the context of other major American manufacturer's current behavior.
Well, it's not as if New York is catapulting it's garbage into New Jersey. There's a financial compensation that New Jersey's comfortable with. Otherwise, they'd say to just move along.
You're mostly right, of course, although I'd argue two minor but significant points: one, it's beholden upon everyone to reduce consumption, for national fiscal survival if not for environmental reasons, and New York compounds their ridiculous over-consumption via the extra energy costs of all this poor planning and shipping trash up and down the eastern seaboard. It's waste upon waste, bad money after bad, that anyone with even a trace of environmentalism or frugality in their blood can and should ridicule freely.
Second, while someone in New Jersey, including probably the governor's office, feels it's profitable to accept trash from NYC I highly doubt the immediate neighbors of these landfills are the parties getting that profit. I doubt the governor or any waste-management magnates live within a mile of a mega-ton landfill, downwind of the horrendous stench, in which the great state of New Jersey and it's businesses are harshly abusing their own citizens and customers.
I'd like to know how much of this trash comes from New Jersey and how much comes from New York City.
NYC handles little of its trash in the city, a minority of it in New York state, and otherwise sends it all into New Jersey, on barges and rail cars to Tennessee and Virginia, etc. Pretty much every sanitation policy of NYC constitutes a fiscal and environmental disaster. New Jersey may be wasteful and rude as well, for all I know, but I'm betting the majority of the extra trash comes from New York. This problem just might disappear if New York were to construct a few of the (profoundly environmentally friendly and electricity producing) new models of incinerator or build landfills in their own damn state. I'm not from any state discussed in my rant, by the way; I just think New York is an all-consuming, wasteful jerk of a city.
Better RTFA before you complain too much; warrants aren't the only method of police oversight and just because it didn't require a warrant doesn't mean gathered data will be automatically or easily permitted in court. It's possible, though I admit unlikely, that oversight of GPS tracking will be completely effective and complete even without warrant requirements. Complaints about this ruling may also be a moot point within a year or so; I can already hear the keyboards clacking as every ACLU lawyer between Seattle and Pheonix prepares their case to push this issue up to SCOTUS.
In any case, I'm still damn happy to have moved to North Carolina and out from under the 9th Circuit. I'm not conservative or liberal in particular, but I've always considered them fucking nuts.
Slashdot Mirror
That people have discovered that the intermediate step is also adjusted can hardly be called a shock.
Yes, it is a shock. The prevailing thought was that the RNA was transcribed faithfully and then that perfect transcript of the DNA was sliced up in strange ways. These people have discovered that the transcript may never have been perfect at all.
Imagine cutting up a loaf of bread: The geneticists were quibbling about how thick the slices were and how to arrange it on the plate, all without paying attention to what kind of bread they used. Now suddenly they've noticed that the recipe for french bread gave them a sourdough loaf while they aren't looking, and it may not be about the slicing as much as about how the right recipe is giving them the wrong thing to cut up.
The summary and the abstract really say almost nothing other than to confirm that the misspellings aren't random and don't seem like lab artifacts.
I'd be interested to know how conservative these mistakes tend to be. If the mistakes generally replace amino acids with very similar ones it might be a programmed method of prodding just how much variation a structure can take while remaining functional. Weird and random events, which can be only so weird and so frequent before everything breaks entirely, are necessary for evolutionary adaptation, and these weird protein errors might be a previously unknown mechanism of exploring slightly different structures for proteins and seeing how far an organism can push the envelope.
You can't legally patent something with 7 billion instances of prior art, nor should you be able to acquire a patent that all seven billion people in the world will involuntarily infringe ten million times a day.
Thank you, Justice Department, for another flash of the blindingly obvious.
Of course, if the DOJ has to spell this out, and the institutes that control our federal research dollars in health still can't see it, how does this bode for truly cooperative health research in the US? Not well, I'm guessing.
with a significantly larger kinetic energy than the LHC's beams.
It's hardly surprising or noteworthy that a hundred-ton train moving at 200 mph has more kinetic energy than a particle accelerator, because the accelerator manipulates extremely small masses and doesn't rely on kinetic energy to propel them. As far as I know the only kinetic energy involved is that of the tiny masses moving under magnetic propulsion and then crashing into things (or each other) at really high speed. So why is the above statement relevant or interesting in the least?
Instead, they propose a "family of interconnected theories" might emerge
Which, if you read them all at the same sitting and follow all the connections, just might read like one big...unified theory.
This seems very, very close to a distinction without a difference.
And it has made them the richest country in the world.
If I could quibble a bit here, I'm not sure they're actually the most wealthy nation in the world as measured by total assets, and I'm almost certain they're still on the lower half in terms of assets per person. Just because they're getting trillions in export sales and US debt payments doesn't mean they're particularly wealthy in any socially meaningful sense; there's 1.2 freaking billion of them to split that pie, and it's split even more unevenly than in the US. Only the upper class, as in top 20% or less, live as well as or better than Americans with the median income.
They may have a ridiculous pile of cash and a huge industrial machine, but it's not doing all that much for them so far.
They're only aware of a prior owner having registered the dog, and not necessarily of the fact that he was stolen. It's entirely possible and not improbable that they bought the dog from the thief, eventually decided they wanted him chipped, and view the whole matter as simply a need to update some records to reflect what they consider a legal change of ownership.
Nothing says or implies the new owners actually know he was stolen, and the company has probably declined to tell the new owners anything more than they've told Mr. Moorhouse, if the new owners even got enough information to become suspicious of any problems.
The state is best to enact this extremely modest tax increase
I agree that the rates are reasonable, but I wouldn't call 5% over 200k or 9% over 500k "extremely modest". Those are substantial percentages, especially considering Washington also has sales tax of ~8.8% depending on your location and that federal income tax also applies.
I agree with the tax, but it's bullshit to imply that rich people, at least those who don't dodge all their taxes, pay practically nothing.
Except that there would be other passengers there to spoil the view, and fuel. That would be weird.
I don't know how much other passengers would spoil the view, but I think fuel generally lives primarily in the wings, and jet-fuel kerosene is transparent in the first place.
So a wealthy company internationally famous for its creative and lavish benefits to employees, a company with a share price of $480, paid a total of $4,000 to outsiders who informed them of 10 major bugs in their software? They paid out $400 per bug?
The bounty for finding and documenting a bug in a Google product isn't even enough to buy one share of Google stock? That's downright insulting
Um, is appleinsider really the best place to get non-biased Apple information?
Four sellers doesn't have to be an oligopoly, but that's how they've chosen to behave.
Actually, they do have to be an oligopoly. I can't remember the reference, but the book "Raising Less Corn, More Hell" included citations of an economist whose data suggested that when 4 or less competitors control 65% or more of a market they will automatically collude to control prices. Note that I say automatically and not [necessarily] intentionally; the source contended that market forces will affect each company such that, if profits are their main priority, then even without collusion they will effectively set prices and maintain them rather than compete on them. The source claimed the effect was so strong that they wouldn't undercut one another even if they didn't know each other *existed*. Markets with few sellers don't work out well for consumers, even when the sellers aren't money hungry pricks, and cell phone companies clearly are.
I think it's going to move Skype away from Consumers and into the Business world where the real money is.
Not necessarily. Cisco certainly does more business with the corporate world, but look at Linksys: WRT-54 routers have been the Cadillac of home and small enterprise wifi for a decade, and Linksys is nothing more or less than the consumer brand-name for Cisco.
If they treat Skype the way they treat Linksys, there's no reason to assume they'll do anything deleterious to private user's experience.
attaching the Internet Kill Switch bill as a rider
It's also possible that certain Senators are pretending to like this provision because they know its inclusion could kill the entire bill, a bill they despise secretly but cannot dislike openly. It's called a poison pill in parliamentary terms; an addition which, by design, makes a bill less attractive to its original supporters and may not be favored even of the person submitting it.
Pilot unions have objected to the collection and sharing of detailed accident data, citing privacy concerns of the flight crew.
I wasn't aware any reasonable expectation of privacy existed while working on a 4-8 person crew serving a couple hundred people in a space the size of a double-wide mobile home. Not to mention, just what other profession entitles you to privacy while at work, especially the sort of work where owners and direct supervisors are almost never in the same time zone as a given employee? They apparently feel entitled to privacy in a case where privacy would mean no oversight whatsoever.
Pilot unions have objected to the collection and sharing of detailed accident data, citing privacy concerns of the flight crew.
I wasn't aware any reasonable expectation of privacy existed while working on a 4-8 person crew serving a couple hundred people in a space the size of a double-wide mobile home. Not to mention, just what other profession entitles you to privacy while at work, especially the sort of work where owners and direct supervisors are almost never in the same time zone as a given employee? They apparently feel entitled to privacy in a case where privacy would mean no oversight whatsoever.
Well, it might suck, but presuming the legal basis of the court ruling is valid, I'm appreciative that they shut the experiments down.
Before you flame me into a crispy marshmallow, answer me this: Is the NIH the sort of institution you want playing fast and loose with any law or court ruling that isn't blatantly, obviously unconstitutional or an instantaneous danger to human lives? I want NIH crossing their T's and dotting the shit of out their I's, for my own safety and peace of mind, and while I hope they fight this ruling (because stem cells will save lives in the long run) I'm grimly satisfied they obeyed it while it's legally binding.
And there's that again. Not one single time in a decade on forums have I ever pointed out that people are assholes to conservatives and creationists without everyone instantly assuming I was one and merely pissed off about being personally attacked. I am not either, sir, I'm just tired of the stupid, preening self-righteousness that slashdot has in abundance. And your cute sarcastic response is, at very best, the pot calling the kettle black.
Whoever moderated such a statement "Informative" should be shot. It's nothing but a self-righteous, stereotyping flame, and everyone here knows it, but some genius feels the need to mod it "Informative" solely because it fits the typical vapid mockery of conservatives, creationists, and everyone else slashdotters feel empowered to judge.
Oh my god...you've done it...you've set the all time slashdot record for trolls/character used in a single posting.
I bow humbly before your prowess, oh mighty one.
Also, you tied for Most Unnecessarily Hyphenated Words Intended Solely to Make You Look Smart.
To the few people here who apparently believe paranoid conservative conspiracy theorists vandalized Google to obscure the location of this rally: are you completely insane?
I mean, follow the bouncing ball: you're so paranoid that you'd like to hide the location of a giant rally by desecrating Google maps, but you've scheduled said rally at a landmark so famous tens of millions could find it with no maps at all? And how are fellow paranoid conservatives supposed to find said rally? Does Glenn Beck's web page include coded directions, decipherable only by clues so small you'd never notice them if you hadn't read Ronald Reagan's autobiography twelve times?
You may think Glenn Beck listeners somewhat clinically paranoid and/or politically foolish, but you don't look any smarter, more rational, or less paranoid in believing them both smart enough and rationally motivated to vandalize the map but otherwise too stupid to tie their own shoes.
Kudos to Garmin for proactively recalling their own unit before anybody dies or they have a growing public relations nightmare on their hands. It's much better stewardship of their brand and care for their customers than we ever see from car companies or medical device manufacturers.
Of course, it's also disheartening that the appropriate minimum response to discovering a serious flaw in one's product now feels extraordinary and laudable when viewed in the context of other major American manufacturer's current behavior.
Well, it's not as if New York is catapulting it's garbage into New Jersey. There's a financial compensation that New Jersey's comfortable with. Otherwise, they'd say to just move along.
You're mostly right, of course, although I'd argue two minor but significant points: one, it's beholden upon everyone to reduce consumption, for national fiscal survival if not for environmental reasons, and New York compounds their ridiculous over-consumption via the extra energy costs of all this poor planning and shipping trash up and down the eastern seaboard. It's waste upon waste, bad money after bad, that anyone with even a trace of environmentalism or frugality in their blood can and should ridicule freely.
Second, while someone in New Jersey, including probably the governor's office, feels it's profitable to accept trash from NYC I highly doubt the immediate neighbors of these landfills are the parties getting that profit. I doubt the governor or any waste-management magnates live within a mile of a mega-ton landfill, downwind of the horrendous stench, in which the great state of New Jersey and it's businesses are harshly abusing their own citizens and customers.
I'd like to know how much of this trash comes from New Jersey and how much comes from New York City.
NYC handles little of its trash in the city, a minority of it in New York state, and otherwise sends it all into New Jersey, on barges and rail cars to Tennessee and Virginia, etc. Pretty much every sanitation policy of NYC constitutes a fiscal and environmental disaster. New Jersey may be wasteful and rude as well, for all I know, but I'm betting the majority of the extra trash comes from New York. This problem just might disappear if New York were to construct a few of the (profoundly environmentally friendly and electricity producing) new models of incinerator or build landfills in their own damn state. I'm not from any state discussed in my rant, by the way; I just think New York is an all-consuming, wasteful jerk of a city.
Better RTFA before you complain too much; warrants aren't the only method of police oversight and just because it didn't require a warrant doesn't mean gathered data will be automatically or easily permitted in court. It's possible, though I admit unlikely, that oversight of GPS tracking will be completely effective and complete even without warrant requirements. Complaints about this ruling may also be a moot point within a year or so; I can already hear the keyboards clacking as every ACLU lawyer between Seattle and Pheonix prepares their case to push this issue up to SCOTUS.
In any case, I'm still damn happy to have moved to North Carolina and out from under the 9th Circuit. I'm not conservative or liberal in particular, but I've always considered them fucking nuts.