'It's thanks to the wonders of genetic engineering that soon there will be an end to hunger, disease, pollution, even war. I have created things that will change the world for the better. For instance, here is a monkey with four asses.'
As noted above, she was dreaming of the post-war future, though of course she never saw it. Her revision was prompted by a 'Radio Orange' radio broadcast from an exiled Dutch Government Minister in London, suggesting that wartime diaries and documents would be preserved after the Liberation as a record for future generations. But she can hardly have imagined that hers would become the most famous of all diaries of the Occupation.
From what I understand, the diary as published wasn't written by Anne but by her father largely/loosely based on her diary.
Your understanding is incorrect. There are two versions of the diary in Anne Frank's own handwriting - her original, and a more polished version she edited with a view to post-war publication. Otto Frank assembled the published book from both of Anne Frank's versions, excluding some passages but not adding new material. You can directly compare the three versions line by line in the original Dutch or in English translation in the Critical Editions published by the Netherlands Institute for War Documentation. The words are Anne Frank's, not her father's. He selected from the extant material, but did not re-write or invent.
After entering page after page of code only to have it not work, we found, the back of the book, a small note about how the authors intentionally left errors in the code that you had to troubleshoot.
'Hey Bob, this doesn't even compile! You know the print deadline is tonight, right?'
'Sorry, I'm going bowling at 6. Just stick a note in the back saying we made some deliberate errors. Nobody will ever type the whole thing in anyway.'
Though it hasn't yet lived up to its potential (Nanopore sequencing has been Next Year's Big Thing for several years now) it is rather incredible what can be done with such a small and cheap piece of kit. It still has major problems with accuracy, but is starting to find a niche in applications where speed, portability and long sequence reads are required. Here's a nice piece from a fan of the technology that has a bit of history and an appraisal of where it stands in 2016: http://omicsomics.blogspot.co....
30x is generally considered adequate for variant calling from routine whole genome sequencing using standard Illumina technology, which has a reasonable error rate. But this figure (30 reads covering each base) is just the average of a Poisson distribution - according to Illumina 'the data would be expected to fall to 15x or below about 0.2% of the time', so there will always be some poorly covered bases where we can't confidently call variants.
The biology can also make things interesting - e.g. mosaicism and copy number variations can mean that there are interesting variants at low allelic ratios (i.e., much lower than the 50% you'd expect from a heterozygous change). Cancer is a major challenge, partly because the tumour may be mixed (effectively diluted) with normal tissue (e.g. from blood) reducing our ability to detect purely somatic changes confined to the cancer, and also because of heterogeneity (many, even most, somatic mutations are not in every cell of the tumour). Because of this, tumours are routinely sequenced at higher depth than normal 'germline' DNA by the UK 100k genome project (and others).
Once upon a time you might have written you prefer quality British-made tools, but they must be pretty thin on the ground now. I have an excellent Norbar torque wrench (Norbar apparently dates back to World War 2, when they made tools for the Merlin aero engine). A bit of Googling suggests that the wonderfully named 'King Dick Tools' are still making stuff here. I now have to go out and buy one of their products, partly to support British industry, but mainly so I can brandish a tool with 'King Dick' written on it.
This project does whole genomes. Even at commercial rates, a 30x depth whole genome is only 2-3x more expensive than an equivalent exome (the difference may be smaller on the scale they are doing this, and sequencing is probably getting cheaper more quickly than target capture, narrowing the gap further). Genomes also give more even coverage at similar depth (capture bias means that some regions are never represented well in exomes, and it's possible to miss exonic mutations that are supposedly covered by the probe set). They are also looking to the future - the aim is to put the infrastructure in place so that genome sequencing can be used routinely by the NHS, they want to boost the UK genomics industry, and they'll have a very large well-documented data set that can be mined in the future.
And now a company will patent her genes, and every insurance company will call this a pre-existing condition and deny treatment for anything related to this or its treatment.
This is a publicly funded project in the UK, which has universal healthcare free at the point of delivery (the NHS). Any IP will be owned by Genomics England, a company owned by the UK Government. They intend to set up licensing agreements with the commercial sector on 'favourable terms'. These terms aren't precisely defined, at least publicly, and I imagine the drug and medical testing companies (who must pay to join a consortium with Genomics England if they want to work with them) may have a different definition of 'favourable' to the IP holders! The intention is presumably to make sure that the NHS doesn't get screwed in the process, but we'll see how this works out in practice. The Conservative Government has something of a conflict of interest between wanting to spend as little as possible on the NHS, while also promoting the UK pharma and genomics industry.
It probably just means the NSA is already using your processor's compute capacity as part of their vast decryption botnet. The fix should improve resource management so you won't notice it in future.
I think the summary could do a better job at reporting news and use SI units -- avoiding such odd ones like a "pint", which are different in the various English-speaking countries to start with.
1 Unit = 10 ml pure alcohol. The smallest spirit measure used in the UK is a 25 ml single shot, equivalent to 1 Unit of a 40% v/v spirit. A 175ml medium glass of a 12% wine will give you just over 2 Units, and a 568 ml UK pint of a 3.5% beer nearly as much. A lot of beer is stronger than this, though - a 5.5% brew will give you over 3 Units per pint.
... greedy, selfish, irresponsible and abusive corporate suits are just thieves producing a lot of over-priced and under-supported crap. These corporations couldn't compete in a free market, so they have to corrupt and control their way to domination.
This must be the most momentous, earth-shattering event since Instagram allowed rectangular photos! My predictions for 2016:
- Snapchat snaps to be viewable for 6 months after opening. - Vine clip limit extended to 90 minutes. - Dice completes gradual 'stealth beta' transformation of Slashdot. - Civilization altering asteroid strike leaves Usenet newsgroups as most important social media.
One exception may be certain parts of the diary that have been published in 1986. Back then, copyright law in several European countries protected a work for 50 years after its first publication instead of until 70 years after the author's death.
That's interesting. I'd assumed that, since the 80s Critical Edition made available Anne Frank's original versions (her diary and her own later edit), they could be extracted and re-published even if there were some merit in the Foundation's case about Otto Frank's contribution to the standard edition. But of course this wouldn't be the case where publication + 50 applies (in which countries?). The other thing worth noting is that under death of author + 70 rules, no current English translation is out of copyright, and won't be for a long time: http://www.raoulwallenberg.net...
Get a job offer, respond angrily for no reason in particular and start harrassing the company who offered the job?
There was no job offer - 'join the team' is poor phrasing from Tim Cushing at Techdirt, in an article that's more distorted and melodramatic than the piece he's complaining about (which doesn't seem particularly angry). The publisher was approached by Google about selling their books via Play. The publisher declined, and pointed out that Google was at the same time making a profit from linking to pirated copies of the publisher's books in its search results. The publisher doesn't seem terribly well informed about how this whole Internet thing operates, but Techdirt's hyperventilating clickbait isn't exactly a model of clarity and accuracy either.
It's all fun and games until someone has a few too many at the NORAD Christmas party, loads the Santa data into the wrong terminal, and the WOPR identifies Dasher, Dancer, Prancer, Vixen, Comet, Cupid, Donner, and Blitzen as an incoming salvo of ICBMs from Murmansk.
Linux->the new spiffy unusable UIs are standard so you need to hunt for a usable one.
To be fair, if it takes more than 5 minutes to find a distribution like Ubuntu MATE, Mint MATE or Mint Cinnamon, or the packages for Xfce, LXDE or MATE in other distributions, then you're doing it wrong.
I also assumed Classic Theme Restorer would probably be affected (even though CTR itself is an extension rather than a theme). But according to the developer:
Slashdot Mirror
The only things I personally can think of are Gavin & Stacy, 2 Pints and The Mighty Boosh
Cross Two Pints off your list!
Add:
Little Britain
Being Human
Torchwood
The Fades (shamefully axed after 1 series)
In the Flesh (managed 2 series before the chop)
Our War
I didn't watch 'Nighty Night', but a lot of people rated it.
VLC will play any region DVD and overcome CSS. The AC is an advert!
Depends on your drive. Some firmware doesn't even allow even raw access to the drive if there's a region mismatch, so libdvdcss won't work.
'It's thanks to the wonders of genetic engineering that soon there will be an end to hunger, disease, pollution, even war. I have created things that will change the world for the better. For instance, here is a monkey with four asses.'
As noted above, she was dreaming of the post-war future, though of course she never saw it. Her revision was prompted by a 'Radio Orange' radio broadcast from an exiled Dutch Government Minister in London, suggesting that wartime diaries and documents would be preserved after the Liberation as a record for future generations. But she can hardly have imagined that hers would become the most famous of all diaries of the Occupation.
TFA: http://www.chicagotribune.com/...
From what I understand, the diary as published wasn't written by Anne but by her father largely/loosely based on her diary.
Your understanding is incorrect. There are two versions of the diary in Anne Frank's own handwriting - her original, and a more polished version she edited with a view to post-war publication. Otto Frank assembled the published book from both of Anne Frank's versions, excluding some passages but not adding new material. You can directly compare the three versions line by line in the original Dutch or in English translation in the Critical Editions published by the Netherlands Institute for War Documentation. The words are Anne Frank's, not her father's. He selected from the extant material, but did not re-write or invent.
After entering page after page of code only to have it not work, we found, the back of the book, a small note about how the authors intentionally left errors in the code that you had to troubleshoot.
'Hey Bob, this doesn't even compile! You know the print deadline is tonight, right?'
'Sorry, I'm going bowling at 6. Just stick a note in the back saying we made some deliberate errors. Nobody will ever type the whole thing in anyway.'
Though it hasn't yet lived up to its potential (Nanopore sequencing has been Next Year's Big Thing for several years now) it is rather incredible what can be done with such a small and cheap piece of kit. It still has major problems with accuracy, but is starting to find a niche in applications where speed, portability and long sequence reads are required. Here's a nice piece from a fan of the technology that has a bit of history and an appraisal of where it stands in 2016: http://omicsomics.blogspot.co....
30x is generally considered adequate for variant calling from routine whole genome sequencing using standard Illumina technology, which has a reasonable error rate. But this figure (30 reads covering each base) is just the average of a Poisson distribution - according to Illumina 'the data would be expected to fall to 15x or below about 0.2% of the time', so there will always be some poorly covered bases where we can't confidently call variants.
The biology can also make things interesting - e.g. mosaicism and copy number variations can mean that there are interesting variants at low allelic ratios (i.e., much lower than the 50% you'd expect from a heterozygous change). Cancer is a major challenge, partly because the tumour may be mixed (effectively diluted) with normal tissue (e.g. from blood) reducing our ability to detect purely somatic changes confined to the cancer, and also because of heterogeneity (many, even most, somatic mutations are not in every cell of the tumour). Because of this, tumours are routinely sequenced at higher depth than normal 'germline' DNA by the UK 100k genome project (and others).
Once upon a time you might have written you prefer quality British-made tools, but they must be pretty thin on the ground now. I have an excellent Norbar torque wrench (Norbar apparently dates back to World War 2, when they made tools for the Merlin aero engine). A bit of Googling suggests that the wonderfully named 'King Dick Tools' are still making stuff here. I now have to go out and buy one of their products, partly to support British industry, but mainly so I can brandish a tool with 'King Dick' written on it.
This project does whole genomes. Even at commercial rates, a 30x depth whole genome is only 2-3x more expensive than an equivalent exome (the difference may be smaller on the scale they are doing this, and sequencing is probably getting cheaper more quickly than target capture, narrowing the gap further). Genomes also give more even coverage at similar depth (capture bias means that some regions are never represented well in exomes, and it's possible to miss exonic mutations that are supposedly covered by the probe set). They are also looking to the future - the aim is to put the infrastructure in place so that genome sequencing can be used routinely by the NHS, they want to boost the UK genomics industry, and they'll have a very large well-documented data set that can be mined in the future.
And now a company will patent her genes, and every insurance company will call this a pre-existing condition and deny treatment for anything related to this or its treatment.
This is a publicly funded project in the UK, which has universal healthcare free at the point of delivery (the NHS). Any IP will be owned by Genomics England, a company owned by the UK Government. They intend to set up licensing agreements with the commercial sector on 'favourable terms'. These terms aren't precisely defined, at least publicly, and I imagine the drug and medical testing companies (who must pay to join a consortium with Genomics England if they want to work with them) may have a different definition of 'favourable' to the IP holders! The intention is presumably to make sure that the NHS doesn't get screwed in the process, but we'll see how this works out in practice. The Conservative Government has something of a conflict of interest between wanting to spend as little as possible on the NHS, while also promoting the UK pharma and genomics industry.
It probably just means the NSA is already using your processor's compute capacity as part of their vast decryption botnet. The fix should improve resource management so you won't notice it in future.
I think the summary could do a better job at reporting news and use SI units -- avoiding such odd ones like a "pint", which are different in the various English-speaking countries to start with.
1 Unit = 10 ml pure alcohol. The smallest spirit measure used in the UK is a 25 ml single shot, equivalent to 1 Unit of a 40% v/v spirit. A 175ml medium glass of a 12% wine will give you just over 2 Units, and a 568 ml UK pint of a 3.5% beer nearly as much. A lot of beer is stronger than this, though - a 5.5% brew will give you over 3 Units per pint.
... greedy, selfish, irresponsible and abusive corporate suits are just thieves producing a lot of over-priced and under-supported crap. These corporations couldn't compete in a free market, so they have to corrupt and control their way to domination.
Perfect partners for FIFA, then.
This must be the most momentous, earth-shattering event since Instagram allowed rectangular photos! My predictions for 2016:
- Snapchat snaps to be viewable for 6 months after opening.
- Vine clip limit extended to 90 minutes.
- Dice completes gradual 'stealth beta' transformation of Slashdot.
- Civilization altering asteroid strike leaves Usenet newsgroups as most important social media.
The RIKEN collaboration team in Japan have fulfilled the criteria for element Z=113 and will be invited to propose a permanent name and symbol
A radioactive super-heavy element from Japan?: Godzillium.
I can only see a Dutch version on that site.
One exception may be certain parts of the diary that have been published in 1986. Back then, copyright law in several European countries protected a work for 50 years after its first publication instead of until 70 years after the author's death.
That's interesting. I'd assumed that, since the 80s Critical Edition made available Anne Frank's original versions (her diary and her own later edit), they could be extracted and re-published even if there were some merit in the Foundation's case about Otto Frank's contribution to the standard edition. But of course this wouldn't be the case where publication + 50 applies (in which countries?). The other thing worth noting is that under death of author + 70 rules, no current English translation is out of copyright, and won't be for a long time: http://www.raoulwallenberg.net...
Get a job offer, respond angrily for no reason in particular and start harrassing the company who offered the job?
There was no job offer - 'join the team' is poor phrasing from Tim Cushing at Techdirt, in an article that's more distorted and melodramatic than the piece he's complaining about (which doesn't seem particularly angry). The publisher was approached by Google about selling their books via Play. The publisher declined, and pointed out that Google was at the same time making a profit from linking to pirated copies of the publisher's books in its search results. The publisher doesn't seem terribly well informed about how this whole Internet thing operates, but Techdirt's hyperventilating clickbait isn't exactly a model of clarity and accuracy either.
It's all fun and games until someone has a few too many at the NORAD Christmas party, loads the Santa data into the wrong terminal, and the WOPR identifies Dasher, Dancer, Prancer, Vixen, Comet, Cupid, Donner, and Blitzen as an incoming salvo of ICBMs from Murmansk.
This just in: according to sources there is strong evidence that one of these travellers had links with a terrorist network in Agrabah:
http://time.com/4155228/amierc...
I hope it's not running Windows... like the last time
Red Hat, apparently: http://arstechnica.com/informa...
Linux->the new spiffy unusable UIs are standard so you need to hunt for a usable one.
To be fair, if it takes more than 5 minutes to find a distribution like Ubuntu MATE, Mint MATE or Mint Cinnamon, or the packages for Xfce, LXDE or MATE in other distributions, then you're doing it wrong.
I also assumed Classic Theme Restorer would probably be affected (even though CTR itself is an extension rather than a theme). But according to the developer:
http://forums.mozillazine.org/...
"Removing support for complete themes should not have any effect on CTR."