Actually I don't vote. Just so people that say stupid things like "You vote for them!" are horribly wrong. Jerk.
Since I am not a US citizen, you are more likely to have voted for this person than me. However well done in taking an extremely general comment very personally. I can just imagine what it must be like to sit as a passenger in your car in heavy traffic, and I despair for any partner you have or may have in the future. May your life continue to be full of rage and hate. Certainly this will lead to an early grave.
On the other hand, consider the possibility that the world does not care about you at all, and internet comments are not all malicious attempts at slandering your "good name" since frankly you are not important enough for anyone to give a shit about.
Single dose =/= maximum daily dose. Don't mix and match study types.
Acetaminophen metabolism follows first order kinetics and has a half life of 4-6 hours, depending on how healthy your liver is and how efficient your enzymes are. Taking one single 2.5g dose is probably enough to saturate your enzymes to the point that some damage will be done. However taking 4g divided in 4 doses of 1g every 6 hours will never get you over 2g total blood concentration since your body will be eliminating the drug.
Of course there's an entire other argument about chronic acetaminophen use depleting glutathione/methionine stores over time, but that's an even different story.
And then there's the other argument about chronic alcohol use, people who already have low glutathione stores and induced CYP2E1 cytochromes ready to zap that acetaminphen into NAPQI the minute it enters the liver - but why bore you with pharmacology when you can get your own doctorate?
Probably not. The snake will die after its liver wears itself out breaking down the Acetaminophen. All that will be left in the snake is a worn-out liver and non-toxic Acetaminophen metabolites.
Actually, acetaminophen is not toxic, but one of its metabolites, NAPQI (N-acetyl-p-benzo-quinone imine) is the one that does the damage by depleting the body's supply of glutathione which is a necessary chemical for many liver reactions. The rapid depletion of glutathione causes liver cells to become exposed to damage from free radicals and other, regular body toxins that would normally be metabolized. This is why acetaminophen toxicity is characteristic for causing centri-lobular necrosis - cells closest to the branch of the portal vein (And hence exposed to the highest concentrations of Acetaminophen-->NAPQI) tend to die first, cells further away tend to hang on to greater supplies of glutathione and survive to process the remaining NAPQI.
Since I'm a medical doctor and not a vet I am unaware as to the specific toxicity mechanism in cats and snakes, but it probably also has to do with this toxic NAPQI metabolite.
Insofar as your argument I would venture that the dead snakes would be full of NAPQI, an unhealthy surprise for any critter eating them that was unable to metabolize this chemical.
or to the economy in general if the government (the people) is expected to pay for it.
[citation needed]
Please look up current government debt and then think about what you just said. Government programs allocate resources in a completely inefficient manner, creating useless jobs, duplicating work, beginning programs that are un-necessary or even obsolete once they finally get around to them, all the while finding the best way to trip up or put barriers in the way of the private sector.
No, government on paper bears no relationship to government in practice. But the good thing is that all the blame gets shifted to you, the voter, and your one tiny little vote. So no one feels responsible.
Spending money is not good for an economy. Spending money EFFICIENTLY is. However time and time again governments (which account for a vast chunk of total spending) have proven themselves to be incapable of this. The government gets a cut of all income AND every single transaction (be it sales taxes, estate taxes, import tariffs, etc) and STILL manages to fail to deliver on its promises, and has to resort to extra taxes for "special" projects that actually turn out to be basic infrastructure. No, I am not in the "government is good" camp.
Doing that is almost certainly against your agreement with the bank.
And speeding is against the law, but almost everyone does it at least once a day.
Please do not attempt to force people to live by all the laws/agreements/licenses they are expected to uphold unless first you can demonstrate being able to do this yourself. Of course the bank states you can't do this, right at the beginning, where they say "do not give your PIN to ANYONE", to cover their asses. However I consider my wife to be an exception. She can empty my entire bank account if she wishes. It's not as if that's where I keep all my money anyway. She'll have a harder time getting at the stock, bonds and real estate.
husbands, wives and other people who trust each other will no longer be able to lend their partner an ATM card and ask them to go take out some cash. Well done banks, for making technology slightly less useful while still allowing a crook to put a gun to your head and force you to make that withdrawal.
Where we are today is that everyone is looking to the government for direction and support.
You make several valid points, however with respect to the above I have to add: The US government is also looking in every pocket and every wallet for loose change to pay for said "direction and support" - or at least the illusion of it.
Making the government buy more stuff by effectively injecting FUD.
Yeah. You keep telling yourself that it's FUD, just like the ultra quiet Chinese sub that popped to the surface 700 yards from the USS Kitty Hawk surprising the hell out of it while it was on exercise, like the Chinese anti-satellite program, like the Chinese having the most impressive engineering and transportation projects this century (as opposed to the most impressive rhetoric and debt), like the millions of people in the largest US cities would be considered a rounding error in big Chinese cities, like the Chinese space program, yeah this is just FUD. Go ahead and have that nap, Mr. Hare, there is NO WAY the tortoise will win the race.
Nice to know that the Australian government is wealthy enough to afford overpriced hardware and makes its purchasing decisions based on marketing and not, say, system specifications.
What I find more disturbing is what has happened since then: We've seen both Petraeus and also some politicians start telling people how Assange and Wikileaks are "responsible" for the lives of soldiers, and are "endangering" the lives of soldiers. I mean yeah, shift the blame why don't you? Wikileaks is surely more responsible for soldier's lives than the politicians and generals who send them as an occupying force without a viable strategy.
Even better, now Petraeus was making comments about how irresponsible Koran-burning would be. So what has happened, in a few short months, is the FIASCO which is the Afghan "war" has now turned into something to club the civilian population about the head with. Anything you do or say that doesn't represent the official government policy means that you're "endangering the lives of our troops".
I am glad I am not American, but why do you keep voting for these people?
The only logical conclusion I can come to, considering the stuff (corn syrup) has been in HEAVY use for decades now, is that the medical "industry" knows, but cannot monetize the solution--removing corn syrup from ones diet. Telling people to stop eating it would actually cut into their business.
Speaking as a doctor I must say that you are completely incorrect in your assumption. While it's obvious that you feel let down in some way because the medical profession apparently isn't based entirely upon your subjective view of the universe and the anecdotal "evidence" you provide for what isn't even a diseases; you then jump to the quite erroneous conclusion that medicine is some sinister money-making scheme and that you are an inconvenient piece of grit in a well oiled machine.
Honestly it's possible that HFCS can produce some level of irritation of the gastric mucosa in susceptible people. High concentrations of sugars or proteins will stimulate the release of large amounts of gastrin which could cause the discomfort you describe. However rest assured that this is the exception, not the rule. You yourself seem not to have come to any harm from it (I fail to see the mention of perforated ulcers or Mallory-Weiss tears in your post) and have found out all by yourself how to avoid your symptoms. Excuse us if we fail to reprint our textbooks because of this. We usually deal with those who are really ill. No conspiracy needed.
unless, of course, it causes some major retailers to not carry those games at all.
I guess I am just biased as a PC-gamer (yeah we still exist). It's been a long time since "retailers" have stocked games for PC anyway... just one more push towards Steam/Gamersgate/torrents should do it...
a game developer would overlook the simple fact that there is a large amount of gamers out there who are Southpaws.
It's roughly 15% of the population. It's far from the majority, but I guess it's up to the manufacturer whether or not they want to cater to this population. Certainly lefties are adaptable people and used to living in a right hand world... aren't they supposed to be the creative ones?
Slashdot Mirror
I remember commercials especially from Billy Mays that would startle me so badly
Obligatory South Park:
Ike? Is that you?
No! That's ignorant! I'm not dead...HI! BILLY MAYS HERE FOR CHIPOTLAWAY...
If you have no idea what I'm talking about, you can watch that episode here.
Tell the bastards to shut the fuck up and get back to work until they actually generate some *real* results.
Thou shalt not brute-force the universe. All Fermi and LHC is good for is inventing a new particle to explain the unexpected behavior of the month.
Luckily we aren't anywhere near 48 cores and there is some time left to come up with a new Linux (Windows?).
Emphasis mine.
Oh please. Don't list an OS that has trouble running on 1 core as a possible solution.
Actually I don't vote. Just so people that say stupid things like "You vote for them!" are horribly wrong. Jerk.
Since I am not a US citizen, you are more likely to have voted for this person than me. However well done in taking an extremely general comment very personally. I can just imagine what it must be like to sit as a passenger in your car in heavy traffic, and I despair for any partner you have or may have in the future. May your life continue to be full of rage and hate. Certainly this will lead to an early grave.
On the other hand, consider the possibility that the world does not care about you at all, and internet comments are not all malicious attempts at slandering your "good name" since frankly you are not important enough for anyone to give a shit about.
Tell this to Hank Johnson, because now he'll really think that Guam will tip over...
Remember, you vote for these people.
Single dose =/= maximum daily dose. Don't mix and match study types.
Acetaminophen metabolism follows first order kinetics and has a half life of 4-6 hours, depending on how healthy your liver is and how efficient your enzymes are. Taking one single 2.5g dose is probably enough to saturate your enzymes to the point that some damage will be done. However taking 4g divided in 4 doses of 1g every 6 hours will never get you over 2g total blood concentration since your body will be eliminating the drug.
Of course there's an entire other argument about chronic acetaminophen use depleting glutathione/methionine stores over time, but that's an even different story.
And then there's the other argument about chronic alcohol use, people who already have low glutathione stores and induced CYP2E1 cytochromes ready to zap that acetaminphen into NAPQI the minute it enters the liver - but why bore you with pharmacology when you can get your own doctorate?
Plus one must remember that the average US citizen no longer weighs 70kg... so actually > 4g.
Probably not. The snake will die after its liver wears itself out breaking down the Acetaminophen. All that will be left in the snake is a worn-out liver and non-toxic Acetaminophen metabolites.
Actually, acetaminophen is not toxic, but one of its metabolites, NAPQI (N-acetyl-p-benzo-quinone imine) is the one that does the damage by depleting the body's supply of glutathione which is a necessary chemical for many liver reactions. The rapid depletion of glutathione causes liver cells to become exposed to damage from free radicals and other, regular body toxins that would normally be metabolized. This is why acetaminophen toxicity is characteristic for causing centri-lobular necrosis - cells closest to the branch of the portal vein (And hence exposed to the highest concentrations of Acetaminophen-->NAPQI) tend to die first, cells further away tend to hang on to greater supplies of glutathione and survive to process the remaining NAPQI.
Since I'm a medical doctor and not a vet I am unaware as to the specific toxicity mechanism in cats and snakes, but it probably also has to do with this toxic NAPQI metabolite.
Insofar as your argument I would venture that the dead snakes would be full of NAPQI, an unhealthy surprise for any critter eating them that was unable to metabolize this chemical.
or to the economy in general if the government (the people) is expected to pay for it.
[citation needed]
Please look up current government debt and then think about what you just said. Government programs allocate resources in a completely inefficient manner, creating useless jobs, duplicating work, beginning programs that are un-necessary or even obsolete once they finally get around to them, all the while finding the best way to trip up or put barriers in the way of the private sector.
No, government on paper bears no relationship to government in practice. But the good thing is that all the blame gets shifted to you, the voter, and your one tiny little vote. So no one feels responsible.
Spending money is not good for an economy. Spending money EFFICIENTLY is. However time and time again governments (which account for a vast chunk of total spending) have proven themselves to be incapable of this. The government gets a cut of all income AND every single transaction (be it sales taxes, estate taxes, import tariffs, etc) and STILL manages to fail to deliver on its promises, and has to resort to extra taxes for "special" projects that actually turn out to be basic infrastructure. No, I am not in the "government is good" camp.
Legoland news reports there has been an outbreak of head-on collisions involving penis buses. Authorities are baffled as to the cause.
This of course consists of research in advanced Lego physics, a prototype for the Large Hardon Collider.
how is all this "Change" working out for you?
Doing that is almost certainly against your agreement with the bank.
And speeding is against the law, but almost everyone does it at least once a day.
Please do not attempt to force people to live by all the laws/agreements/licenses they are expected to uphold unless first you can demonstrate being able to do this yourself. Of course the bank states you can't do this, right at the beginning, where they say "do not give your PIN to ANYONE", to cover their asses. However I consider my wife to be an exception. She can empty my entire bank account if she wishes. It's not as if that's where I keep all my money anyway. She'll have a harder time getting at the stock, bonds and real estate.
models are pink and have rainbows on them
husbands, wives and other people who trust each other will no longer be able to lend their partner an ATM card and ask them to go take out some cash. Well done banks, for making technology slightly less useful while still allowing a crook to put a gun to your head and force you to make that withdrawal.
And we didn't go to jail or risk losing our livelyhoods because of it, either.
Where we are today is that everyone is looking to the government for direction and support.
You make several valid points, however with respect to the above I have to add: The US government is also looking in every pocket and every wallet for loose change to pay for said "direction and support" - or at least the illusion of it.
Making the government buy more stuff by effectively injecting FUD.
Yeah. You keep telling yourself that it's FUD, just like the ultra quiet Chinese sub that popped to the surface 700 yards from the USS Kitty Hawk surprising the hell out of it while it was on exercise, like the Chinese anti-satellite program, like the Chinese having the most impressive engineering and transportation projects this century (as opposed to the most impressive rhetoric and debt), like the millions of people in the largest US cities would be considered a rounding error in big Chinese cities, like the Chinese space program, yeah this is just FUD. Go ahead and have that nap, Mr. Hare, there is NO WAY the tortoise will win the race.
If what they say is true, that homosexuality is a genetic inheritance,
Right. Please explain how homosexuals pass this gene on to their children... Oh wait.
Nice to know that the Australian government is wealthy enough to afford overpriced hardware and makes its purchasing decisions based on marketing and not, say, system specifications.
What I find more disturbing is what has happened since then: We've seen both Petraeus and also some politicians start telling people how Assange and Wikileaks are "responsible" for the lives of soldiers, and are "endangering" the lives of soldiers. I mean yeah, shift the blame why don't you? Wikileaks is surely more responsible for soldier's lives than the politicians and generals who send them as an occupying force without a viable strategy.
Even better, now Petraeus was making comments about how irresponsible Koran-burning would be. So what has happened, in a few short months, is the FIASCO which is the Afghan "war" has now turned into something to club the civilian population about the head with. Anything you do or say that doesn't represent the official government policy means that you're "endangering the lives of our troops".
I am glad I am not American, but why do you keep voting for these people?
I hope some Australian and UK readers can help the rest of us understand the significance of conscience votes,
It's like when in America Nancy Pelosi tells you how to vote.
Also, it's a bit odd that you think angiography when you hear compressed video,
Yes because medical video images are never compressed.
The only logical conclusion I can come to, considering the stuff (corn syrup) has been in HEAVY use for decades now, is that the medical "industry" knows, but cannot monetize the solution--removing corn syrup from ones diet. Telling people to stop eating it would actually cut into their business.
Speaking as a doctor I must say that you are completely incorrect in your assumption. While it's obvious that you feel let down in some way because the medical profession apparently isn't based entirely upon your subjective view of the universe and the anecdotal "evidence" you provide for what isn't even a diseases; you then jump to the quite erroneous conclusion that medicine is some sinister money-making scheme and that you are an inconvenient piece of grit in a well oiled machine.
Honestly it's possible that HFCS can produce some level of irritation of the gastric mucosa in susceptible people. High concentrations of sugars or proteins will stimulate the release of large amounts of gastrin which could cause the discomfort you describe. However rest assured that this is the exception, not the rule. You yourself seem not to have come to any harm from it (I fail to see the mention of perforated ulcers or Mallory-Weiss tears in your post) and have found out all by yourself how to avoid your symptoms. Excuse us if we fail to reprint our textbooks because of this. We usually deal with those who are really ill. No conspiracy needed.
unless, of course, it causes some major retailers to not carry those games at all.
I guess I am just biased as a PC-gamer (yeah we still exist). It's been a long time since "retailers" have stocked games for PC anyway... just one more push towards Steam/Gamersgate/torrents should do it...
a game developer would overlook the simple fact that there is a large amount of gamers out there who are Southpaws.
It's roughly 15% of the population. It's far from the majority, but I guess it's up to the manufacturer whether or not they want to cater to this population. Certainly lefties are adaptable people and used to living in a right hand world... aren't they supposed to be the creative ones?