Disclaimer: I am a biologist, if not working in virology or molecular biology. I actually read the paper.
The findings that the group reports are very interesting - based on the Slashdot headline you wouldn't believe it, but it's actually legit science.
However, there's a big caveat. This drug is a protein, which is a very large molecule. Almost all currently marketed drugs are small molecules, which is a huge difference to the body. You will never be able to administer this drug orally, as to the body it is "food" and will be degraded in the stomach. If you inject it, cells will not take it up and it will not be effective. This is why they attached sequences to the protein that make transduction (crossing of cell membranes into cells) possible. These sequences come from somewhat "dodgy" sources. One of them is actually a part of HIV. It is completely unclear how the body will react to that. The construct might, for example, trigger an intense immune response.
That said, I am delighted to see this kind of work published. Basically, people are reaping the fruits of decades of basic research in molecular biology to design drugs that can be "programmed" to do whatever you want. If the technical limitations can be overcome (that is, once proteins can be delivered to cells very specifically and non-invasively and once the cell killing mechanism can be made super specific), great innovations in medicine will become possible.
Just FTR: "Vaporware" is, i guess, actually quite an adequate term for hydrogen-fuelled equipment. Should it produce anything besides vapor, things are obviously not quite right;b
Fuckin' "blogosphere" losers trying to be cool by pretending to know more than jack shit and promote some new browser just because everybody else was doing it. Nobody with the slightest bit of common sense bought into that firefox-is-god^H^H^Hpanacaeum bullshit. It's another browser and it's not bad. So? What an abstruse idea to promote its security when obviously practically nobody was even looking for security problems. All those fucktards achieved was make exploits for gecko-based browsers plausible in the wild.
All hail common sense. And yeah, fuck the firefox-hipsters.
It amazes me sometime that we can all work and live together in a fairly civil manner, with such conflicting views. Perhaps, considering this, we deserve more credit that we are given.
You deserve credit because you can somehow live together in spite of the controversy surrounding a politician's statement about technology during an electoral campaign? Hah! If that deserves credit, then really nobody should wonder about millions being killed all around the world for slightly more important motives.
Well, the way I and most kids I knew who played with LEGO did it was to build the branded thing according to the plan first, enjoy the nice and polished look of it... And shortly thereafter, break it down to salvage all the cool "special" parts from the theme and use those to built nice (and mostly colorful, hard to stick to one color when you mix themes;)) things with glowing antennas and such...:) I guess that's the way it's meant to be done. The themed sets contain a lot of parts you won't get anywhere else.
Lindows recommends to save the data either over a network or to a USB Memorykey. Actually this is not a bad idea, one can imagine a lot of possible uses for an extremely cost-effective PC... with 64MB or so on a MemoryKey, that's nice, especially as you can carry those around.
If you're happy with 10MBit, then using the coax cables for TV that are already in your walls is a cool thing. You can simply turn your TV-outlet into a LAN-outlet that way:) That's what I do...
Everybody know the real inventor of nuclear powered spacecraft is Professor Calculus! http://www.francetv.fr/jeunesse/momes/t intin/en/av entures/albums/objec.html http://www.francetv.fr/ jeunesse/momes/tintin/en/av entures/albums/march.html
Wow! I wonder where that Terraflop will bring these guys! Is that some kind of new scale for supercomputers: Measure how many "terra"'s they power? (The earth had 1 Terraflop in Douglas Adam's books).
That's not true... The XBox runs a stripped down version of Window 2000, as you can read at the Xbox-Linux site. These guys managed to get Apache running on that minimal W2k.
Also check out xbox-linux.org - It' run by h07 (h07.org) and aims at eventually getting apache to run on linux on the xbox. They already got apache to run on the xbox os (a stripped down win2k) using microsofts xbox sdk.
I was always wondering how google could mirror almost the entire internet and server millions of hits, I mean, it would need super super super fast storage... DRAM is at least a step in that direction... They must have a fsckin LOT of it tho:) A few TB...
Who needs wireless games, when the actual wireless technologies, like cellulars stil suffer from extreemly limited bandwith, bad and small displays etc.
Unless the breakthrough on the hardware part comes (theres some pretty cool stuff in japan already), games on such devices make only limited sense...
"Lessis-Moore", invented by the smart lzip people - lzip.sf.net
Yet another package management system?
on
OpenPKG 1.0 Released
·
· Score: -1, Troll
Wouldn't it have been smarter to port an existing advanced package management system/format like.deb to other UNIX flavours rather than inventing yet another system? Isn't that some serious reinventing-the-wheel?
heh, this is one of the best troll stories i've ever read - if you wrote it yourself, you have some talent:) too bad you waste it on slashdot trolling...
Let's all convince our governments that owning such a machine is vital for scientific progress (finding aliens, cracking rc5 keys, etc) and get them to sponsor such a box to each and every citizen!
Slashdot Mirror
Disclaimer: I am a biologist, if not working in virology or molecular biology. I actually read the paper.
The findings that the group reports are very interesting - based on the Slashdot headline you wouldn't believe it, but it's actually legit science.
However, there's a big caveat. This drug is a protein, which is a very large molecule. Almost all currently marketed drugs are small molecules, which is a huge difference to the body. You will never be able to administer this drug orally, as to the body it is "food" and will be degraded in the stomach. If you inject it, cells will not take it up and it will not be effective. This is why they attached sequences to the protein that make transduction (crossing of cell membranes into cells) possible. These sequences come from somewhat "dodgy" sources. One of them is actually a part of HIV. It is completely unclear how the body will react to that. The construct might, for example, trigger an intense immune response.
That said, I am delighted to see this kind of work published. Basically, people are reaping the fruits of decades of basic research in molecular biology to design drugs that can be "programmed" to do whatever you want. If the technical limitations can be overcome (that is, once proteins can be delivered to cells very specifically and non-invasively and once the cell killing mechanism can be made super specific), great innovations in medicine will become possible.
Just FTR: "Vaporware" is, i guess, actually quite an adequate term for hydrogen-fuelled equipment. Should it produce anything besides vapor, things are obviously not quite right;b
Fuckin' "blogosphere" losers trying to be cool by pretending to know more than jack shit and promote some new browser just because everybody else was doing it. Nobody with the slightest bit of common sense bought into that firefox-is-god^H^H^Hpanacaeum bullshit. It's another browser and it's not bad. So? What an abstruse idea to promote its security when obviously practically nobody was even looking for security problems. All those fucktards achieved was make exploits for gecko-based browsers plausible in the wild.
All hail common sense. And yeah, fuck the firefox-hipsters.
...or is it a matter of achieving a balance?
Yes.
It amazes me sometime that we can all work and live together in a fairly civil manner, with such conflicting views. Perhaps, considering this, we deserve more credit that we are given.
You deserve credit because you can somehow live together in spite of the controversy surrounding a politician's statement about technology during an electoral campaign? Hah! If that deserves credit, then really nobody should wonder about millions being killed all around the world for slightly more important motives.
Aha. Spam filters might incorrectly classify some emails. Yes, even important ones! ...nothing to see here
Well, the way I and most kids I knew who played with LEGO did it was to build the branded thing according to the plan first, enjoy the nice and polished look of it... And shortly thereafter, break it down to salvage all the cool "special" parts from the theme and use those to built nice (and mostly colorful, hard to stick to one color when you mix themes;)) things with glowing antennas and such...:)
I guess that's the way it's meant to be done. The themed sets contain a lot of parts you won't get anywhere else.
Such results give more insight about the validity of such studies than about anything related to either marijuana or email. Absurd.
Indeed. The GNOME/KDE folks should have patented it;)
Lindows recommends to save the data either over a network or to a USB Memorykey. Actually this is not a bad idea, one can imagine a lot of possible uses for an extremely cost-effective PC ... with 64MB or so on a MemoryKey, that's nice, especially as you can carry those around.
>[..] machinima, which are "animated movies..
>utilizing the [real-time] 3-D graphics engines of
>games like Quake or Unreal [..]
Hey, what about movies that aren't animated?
If you're happy with 10MBit, then using the coax cables for TV that are already in your walls is a cool thing. You can simply turn your TV-outlet into a LAN-outlet that way :) That's what I do ...
Everybody know the real inventor of nuclear powered spacecraft is Professor Calculus!t intin/en/av entures/albums/objec.html/ jeunesse/momes/tintin/en/av entures/albums/march.html
http://www.francetv.fr/jeunesse/momes/
http://www.francetv.fr
Wow! I wonder where that Terraflop will bring these guys! Is that some kind of new scale for supercomputers: Measure how many "terra"'s they power? (The earth had 1 Terraflop in Douglas Adam's books).
Imagine a Beowulf Cluster of those...
That's not true... The XBox runs a stripped down version of Window 2000, as you can read at the Xbox-Linux site. These guys managed to get Apache running on that minimal W2k.
From the headers of that email:
;
Received: from pkdt.proxel.ru ([194.190.195.189]:21594 "HELO pkdt.proxel.ru")
by vger.kernel.org with SMTP id
Mon, 1 Apr 2002 03:07:05 -0500
There were some problems with alsa and arts with yamaha ds-xg soundcards... a lot of fixes went into 2.4.x for arts and oss with those cards...
So, does that mean that arts for yamaha ds-xg just got broken?
Also check out xbox-linux.org - It' run by h07 (h07.org) and aims at eventually getting apache to run on linux on the xbox. They already got apache to run on the xbox os (a stripped down win2k) using microsofts xbox sdk.
I was always wondering how google could mirror almost the entire internet and server millions of hits, I mean, it would need super super super fast storage... DRAM is at least a step in that direction... They must have a fsckin LOT of it tho :) A few TB...
Who needs wireless games, when the actual wireless technologies, like cellulars stil suffer from extreemly limited bandwith, bad and small displays etc.
Unless the breakthrough on the hardware part comes (theres some pretty cool stuff in japan already), games on such devices make only limited sense...
"Lessis-Moore", invented by the smart lzip people - lzip.sf.net
Wouldn't it have been smarter to port an existing advanced package management system/format like .deb to other UNIX flavours rather than inventing yet another system? Isn't that some serious reinventing-the-wheel?
heh, this is one of the best troll stories i've ever read - if you wrote it yourself, you have some talent :) too bad you waste it on slashdot trolling...
Let's all convince our governments that owning such a machine is vital for scientific progress (finding aliens, cracking rc5 keys, etc) and get them to sponsor such a box to each and every citizen!