Wrong - I don't think cost is the key. Look at games like Maplestory or Runescape. Free games (mostly) but almost as addictive. I think it is the leveling, the competition, and all the little RPG elements that keep people coming back for more.
As a student on a campus in a state that I am not a long-term resident of, I can't in good conscience push my opinion on the way things should be run locally. Who am I to push liberal or socialist agendas on a town that clearly does not agree with that mentality, simple because I go to school there for a couple of years? Now, I certainly don't mind voting for national congressman and senators, since they will have an influence slightly beyond their own state borders (especially senators). But again, I think that students and others living temporarily in a place should weigh the pros and cons of adding their voice to local issues.
I don't see Bush getting rid of this one. How else will he encourage the creation of new choice drugs for his blissful post-presidency snortfest? Even good christians have to get their drugs
Who doesn't like roasted nuts? Much healthier than salted, and better tasting than unsalted. Make sure to always roast your nuts. And who said Dells aren't good for you....
Burger Shack Employee: You guys might have wanted to stay away from our special sauce tonight. Me and Pookie, we added a secret ingredient. I'll give you a hint. It's semen.
Actually I completely agree with what you said - my rebuttle was aimed at the statement "starting from scratch, we probably couldn't do much better than what our planet has already provided". I agree that we have stagnated human evolution due to a lack of selective pressure, but to assume that our end product (current humans) is somehow ideal is wrong.
I think it is a bit presumptuous to think that we are the pinnacle of perfection. In fact, our very design is inefficient because of backward compatibility. For example, our brain is designed the way it is (cortex on the outside) because it developed most recently on top of a preexisting brainstem. This is not the most efficient layout for the way it is connected (from an engineering perspective).
If I could make a rather silly analogy, one could compare this to Apple vs Windows/Linux, where the newly designed organism is an Apple machine and the current version is Windows. Sure the current version works fine, but it has some minor flaws and is hampered in its development because it has to support a lot of archaic hardware (backwards compatibility), a lot of which is not used anymore. Contrast this with Apple that tends to "reinvent" the machine with a rather callous disregard (in most cases) for its predecessors. What you get is something that is usually more efficient (from a space and power consumption perspective) and pushes the boundaries of an OS a bit more. I strongly believe that a similar perspective with organism design could yield equally interesting results.
According to a paper by Sanchez et al (2005) titled "Expression of the transient receptor potential vanilloid 1 (TRPV1) in LNCaP and PC-3 prostate cancer cells and in human prostate tissue." the vanilloid receptor is expressed in these prostate cells. In fact, this is very often the case - cancer cells express extracellular markers and receptors drastically different from their "normal" counterparts. This has been a source of intense study, since it is possible to target cancer cells and not normal cells this way (by finding the difference).
So really the effect on these cancer cells probably has nothing to do with neurons - it has to do with the expression of these vanilloid receptors (which are the receptors for Capsaicin)
Yup, I started out with the great Vic 20 too (that my parents got for attending one of those timeshare seminars). We had it for about half a year before the power supply suddenly started smoking and begin to MELT. Fast forward to today, where I continue the trend and have now started to melt processors. Some things never change
When even the peaceful protestors are chanting things like "Death to America, Death to Israel", is it painfully obvious that this is really NOT about religion. These people (and I use the term as a LARGE generalization) have so much repressed anger about their perceived state of the world that they will look for any slight as an excuse to react violently. I think is is further compounded by the fact that there is still a large population of uneducated, poor Muslims who are much like poor, uneducated Christians in the US - they have twisted their respective religions around to justify whatever moronic behavior they truly desire (like little children justifying their actions). And they will listen to anyone who gets on their soapbox and tells them to light the torches. But it is still VERY distressing that these pseudo-Muslims in particular have such a blatant disregard for human life, including their own. Things seem to be really sliding downhill...
Most of these journalists probably used to recieve a handful of actual letters detailing how stupid their article was back in the pre-web days. Really the only difference here is the volume and the anonymity (boy that doesn't look spelled right). Even if they were particularly nasty before, I doubt the editors or the powers that be ever decided to yank the articles. Don't see why it should be any different now.
That being said, I know when someone posts mean things about me on a message board I curl into a little ball under my desk and cry.
Do you by chance have a citation? I am by no means still up to date with all the literature (having done the exam years ago). I thought that the cells you mentioned would not be in the CNS in any significant amount. And I thought that this was due mainly to expression of MIP-1alpha, which retards their proliferation and entry into the site of injury in the CNS. But I could be mistaken (my memory isn't what it used to be).
I don't think this technique (alone) could help with CNS injuries. From what I remember ( I did a prelim exam on nerve regeneration during graduate school) the CNS is immunosuppressed. That means that macrophages cannot enter the site of trauma to clear away debris from dead or damaged cells. This debris has been shown to INHIBIT nerve growth/regrowth. This limitation is not really there in PNS damage.
If the "nose technique" is coupled with something to remove the debris (or to LOCALLY allow macrophages back into the vicinity of the trauma) then it might be successful.
I for one think this is excellent work with some tremendous potential.
I think a more interesting question is, if people are in violation of the no complaining rules, how do you complain about THEM without breaking the rules?
Just give them some nachos (with jalepenos)
on
Slacker or Sick
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· Score: 1
Give them a plate of nachos (with lots of jalepenos) and watch that productivity go right back up. Capsaicin, one of the things that makes peppers hot, blocks the activation of certain cytokine-induced transcription factors (like NF-kB)
I don't know about anyone else, but I frequently watch re-encoded/compressed movies on my pda (a 2 hour movie takes up about 256 MB on a CF card). They look great, the sound is great, and I don't have to worry about carrying DVDs. The only downside is the size of the PDA and the capacity of the CF cards. Both seem to be addressed in the new apple device, if the specs are true. Put me down for one
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Stop picking on us rich folk - we've done nothing to deserve it *wipes ass with $100 bill while lighting another $100 bill instead of a match*
Wrong - I don't think cost is the key. Look at games like Maplestory or Runescape. Free games (mostly) but almost as addictive. I think it is the leveling, the competition, and all the little RPG elements that keep people coming back for more.
As a student on a campus in a state that I am not a long-term resident of, I can't in good conscience push my opinion on the way things should be run locally. Who am I to push liberal or socialist agendas on a town that clearly does not agree with that mentality, simple because I go to school there for a couple of years? Now, I certainly don't mind voting for national congressman and senators, since they will have an influence slightly beyond their own state borders (especially senators). But again, I think that students and others living temporarily in a place should weigh the pros and cons of adding their voice to local issues.
I don't know about the rest of you, but my farts already smell like bakery fresh cinnamon rolls
I don't see Bush getting rid of this one. How else will he encourage the creation of new choice drugs for his blissful post-presidency snortfest? Even good christians have to get their drugs
Who doesn't like roasted nuts? Much healthier than salted, and better tasting than unsalted. Make sure to always roast your nuts. And who said Dells aren't good for you....
Or better yet, some really lucky guys dating multiple women :P Unfortunately, all it really means is a great deal more males than female.....
I don't what it is he said on the blog you linked to, but for some inexplicable reason I now have the urge to listen to some Metallica...
Burger Shack Employee: You guys might have wanted to stay away from our special sauce tonight. Me and Pookie, we added a secret ingredient. I'll give you a hint. It's semen.
Harold: Semen?
Burger Shack Employee: Animal semen.
What's 986 billion years between friends? Sounds like they were in the ballpark already. Any more sarcasm and I think my head will explode.
I for one will welcome my new dissertation writing advisor-robot
Actually I completely agree with what you said - my rebuttle was aimed at the statement "starting from scratch, we probably couldn't do much better than what our planet has already provided". I agree that we have stagnated human evolution due to a lack of selective pressure, but to assume that our end product (current humans) is somehow ideal is wrong.
I think it is a bit presumptuous to think that we are the pinnacle of perfection. In fact, our very design is inefficient because of backward compatibility. For example, our brain is designed the way it is (cortex on the outside) because it developed most recently on top of a preexisting brainstem. This is not the most efficient layout for the way it is connected (from an engineering perspective).
If I could make a rather silly analogy, one could compare this to Apple vs Windows/Linux, where the newly designed organism is an Apple machine and the current version is Windows. Sure the current version works fine, but it has some minor flaws and is hampered in its development because it has to support a lot of archaic hardware (backwards compatibility), a lot of which is not used anymore. Contrast this with Apple that tends to "reinvent" the machine with a rather callous disregard (in most cases) for its predecessors. What you get is something that is usually more efficient (from a space and power consumption perspective) and pushes the boundaries of an OS a bit more. I strongly believe that a similar perspective with organism design could yield equally interesting results.
According to a paper by Sanchez et al (2005) titled "Expression of the transient receptor potential vanilloid 1 (TRPV1) in LNCaP and PC-3 prostate cancer cells and in human prostate tissue." the vanilloid receptor is expressed in these prostate cells. In fact, this is very often the case - cancer cells express extracellular markers and receptors drastically different from their "normal" counterparts. This has been a source of intense study, since it is possible to target cancer cells and not normal cells this way (by finding the difference). So really the effect on these cancer cells probably has nothing to do with neurons - it has to do with the expression of these vanilloid receptors (which are the receptors for Capsaicin)
Fighting for freedom are we?
Yes....Wherever there's trouble, GI Joe is there
I take my porn very seriously. It makes me somber and contemplative. Fun it is not. Nope. Really.
Yup, I started out with the great Vic 20 too (that my parents got for attending one of those timeshare seminars). We had it for about half a year before the power supply suddenly started smoking and begin to MELT. Fast forward to today, where I continue the trend and have now started to melt processors. Some things never change
This make sense to Solomon Grundy - good job mom
When even the peaceful protestors are chanting things like "Death to America, Death to Israel", is it painfully obvious that this is really NOT about religion. These people (and I use the term as a LARGE generalization) have so much repressed anger about their perceived state of the world that they will look for any slight as an excuse to react violently. I think is is further compounded by the fact that there is still a large population of uneducated, poor Muslims who are much like poor, uneducated Christians in the US - they have twisted their respective religions around to justify whatever moronic behavior they truly desire (like little children justifying their actions). And they will listen to anyone who gets on their soapbox and tells them to light the torches. But it is still VERY distressing that these pseudo-Muslims in particular have such a blatant disregard for human life, including their own. Things seem to be really sliding downhill...
Most of these journalists probably used to recieve a handful of actual letters detailing how stupid their article was back in the pre-web days. Really the only difference here is the volume and the anonymity (boy that doesn't look spelled right). Even if they were particularly nasty before, I doubt the editors or the powers that be ever decided to yank the articles. Don't see why it should be any different now. That being said, I know when someone posts mean things about me on a message board I curl into a little ball under my desk and cry.
Do you by chance have a citation? I am by no means still up to date with all the literature (having done the exam years ago). I thought that the cells you mentioned would not be in the CNS in any significant amount. And I thought that this was due mainly to expression of MIP-1alpha, which retards their proliferation and entry into the site of injury in the CNS. But I could be mistaken (my memory isn't what it used to be).
I don't think this technique (alone) could help with CNS injuries. From what I remember ( I did a prelim exam on nerve regeneration during graduate school) the CNS is immunosuppressed. That means that macrophages cannot enter the site of trauma to clear away debris from dead or damaged cells. This debris has been shown to INHIBIT nerve growth/regrowth. This limitation is not really there in PNS damage. If the "nose technique" is coupled with something to remove the debris (or to LOCALLY allow macrophages back into the vicinity of the trauma) then it might be successful. I for one think this is excellent work with some tremendous potential.
I think a more interesting question is, if people are in violation of the no complaining rules, how do you complain about THEM without breaking the rules?
Give them a plate of nachos (with lots of jalepenos) and watch that productivity go right back up. Capsaicin, one of the things that makes peppers hot, blocks the activation of certain cytokine-induced transcription factors (like NF-kB)
I don't know about anyone else, but I frequently watch re-encoded/compressed movies on my pda (a 2 hour movie takes up about 256 MB on a CF card). They look great, the sound is great, and I don't have to worry about carrying DVDs. The only downside is the size of the PDA and the capacity of the CF cards. Both seem to be addressed in the new apple device, if the specs are true. Put me down for one