There are some basic rules when you are making recombinant viruses. one of them is making sure that the virus cannot reproduce in any other thing except the specific strand of bacteria you are using and there are still more safeguards in place.
so don't worry about self powered virus overlords.
OK, for whatever reason, he criticised PS3. If you RTFA, the stuff he mentions sound pretty well founded. By firing him, he was made orders of magnitude famous and many more people are going to read him saying "The XBOX 360 is better". From a developer who was fired for his comments. They gave him credibility, the situation is similar to making a martyr out of an organization's leader by assassinating him. In the long run, it might well turn back on them. just think about Malcolm X and Martin Luther King. I am aware this analogy have flaws, but it illustrates my point IMHO.
I agree that picking children can affect the results of the study. Their own somatic stem cells will be working on the injury already. BUT if the results of this study show a dramatic increase in the rate of injury as opposed to control groups, without side effects (tumor generation?, somatic stem cell teraphy will be a viable option for treating adults.
is cancerous growth of stem cells. Granted, these are not embryonic stem cells (ESCs) but this being the first human trial for somatic stem cells (SSCs) I hope nothing goes wrong. We really don't know every single signal pathway affecting stem cell differentiation, this kind of treatment is really simple, but blind. For example, what will the effect of all those extraction, culturing and IV injection procuders will be on the human SSCs? Some can argue that the current situation of stem cell field is premature for this kind of experiment.
there are several hypothesis about this: why don't humans have regenarative powers? the answer might be that there was never a selective pressure to develop one. in the wilderness if you lose a limb, you are practically dead. so regenerating it does not make sense, there is no selective pressure for it. higher vertebrates mostly lack regeneration potential of lower complexity organisms. regeneration is thougth to be coupled with increased possibility of cancer, so this might be a sensible trade-off.
there is an interesting salamander called axolotl that can grow whole limbs and is currently being studied as a model organism for regeneration studies. in their natural habitat, they lose limbs very often so the ability to grow them back is a useful one. natural selection might have favored them to keep regeneration of this level. (http://www.centralpets.com/animals/reptiles/salam anders/sal2539.html/)
Fascinating.
In summary, this article shows that tumor cells of widely different genetic backgrounds share a common behavior. When tumors grow in vitro, this behavior is completely compatible with MBE universality dynamics. Further, there is sufficiently abundant and clear biological and clinical evidence to suggest that this is also the case in vivo, although further work is needed to confirm this. In any case, a universal tumor growth dynamics is observed for any type of tumor in vivo, independently of any other characteristic of tumoral cell lines. This dynamics is always governed by processes of cell surface diffusion. However, more work is needed to fully determine the whole dynamical behavior of tumor growth. The fractality of the contour of all the studied cell colonies and tumors has been demonstrated. Scaling techniques show that in vitro and in vivo cell proliferation would obey the same dynamics, independent of cell line or any other characteristic. These universal dynamics are compatible with a linear growth regime, a result in contrast with the currently accepted exponential or Gompertzian models of tumor growth. The main mechanism responsible for tumor progression, as for any cell proliferation process, is cell diffusion on the tumor border. These results incorporate the new concept that the major conditioner of tumor growth is space competition between tumor and the host, which is more important than nutrient competition or angiogenesis, etc. The latter must be considered, in some cases, as necessary or as a coadjuvant condition of tumor growth, but their effects mainly consist of modifying the growth rate--perhaps simply allowing it or not. These results invalidate the current concept of cell proliferation and offer a unified view of tumor development. The dynamics involved provide coherent explanations where the traditional model cannot. Despite the importance of characteristics common to the dynamics of the in vivo growth of different tumors, more work is needed to completely characterize them. It should not be forgotten that, independent of interpretations, this article shows for the first time that different tumors have common characteristics such as the distribution of cell proliferation and their characteristic forms (that would imply common basic growth processes), determined via the critical exponents of local and global roughness.
As a result, some important features of cancer can be better explained. Moreover, some clinical strategies may need to be revised.
Interesting. You could say that, these beneficial bacteria of the intestinal tract may not be affected from a loss of communication from fellow bacteria, while at the same time the pathogenic bacteria will stop producing toxins and eventually will be overcome by body's natural defenses. But, this is pure speculation; the case is too complex and will be solved by animal experiments. This looks promising, solely because it does not cause a major selection pressure on bacteria as a killer antibiotic.
I cannot wait to try this with human cells!!
on
Flying By Brain
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· Score: 1
Imagine the possibilities! With a limitless supply of stem cells, you can create actual, adapting human brain in a lab enviroment! I am definitly going to try this! But I think I have to go Saudi arabia or any other desolate place..
In this case, prions are causing the yeast cells to make slightly varied proteins. when they are exposed to stress conditions, some very very few of these infected yeasts gain a more efficient way of survival because of this pre-adaptation, thus by having the upper hand in the competition for limited resources, they are selected for survival. this effect is very similar to any kind of mutagens (mutation causing agents), in fact the main test to determine the potential of a chemical to cause cancer is working with a similar principle. so, to sum it up, they found out that prions can enhance mutation rate (not sure about this, is it really a permanent mutation which is inheritable or an error of post translational mechanism?) of yeasts. so, I don't see a big revolutionary discovery, just a novel discovery of an evolutionary mechanism.
Slashdot Mirror
There are some basic rules when you are making recombinant viruses. one of them is making sure that the virus cannot reproduce in any other thing except the specific strand of bacteria you are using and there are still more safeguards in place. so don't worry about self powered virus overlords.
In the space sim category, Freespace 2 takes the award.
OK, for whatever reason, he criticised PS3. If you RTFA, the stuff he mentions sound pretty well founded. By firing him, he was made orders of magnitude famous and many more people are going to read him saying "The XBOX 360 is better". From a developer who was fired for his comments. They gave him credibility, the situation is similar to making a martyr out of an organization's leader by assassinating him. In the long run, it might well turn back on them. just think about Malcolm X and Martin Luther King. I am aware this analogy have flaws, but it illustrates my point IMHO.
Stem cells may be able to migrate trough the barrier. Who knows? I think immune system cells are able to do it, but I am not sure.
I agree that picking children can affect the results of the study. Their own somatic stem cells will be working on the injury already. BUT if the results of this study show a dramatic increase in the rate of injury as opposed to control groups, without side effects (tumor generation?, somatic stem cell teraphy will be a viable option for treating adults.
is cancerous growth of stem cells. Granted, these are not embryonic stem cells (ESCs) but this being the first human trial for somatic stem cells (SSCs) I hope nothing goes wrong. We really don't know every single signal pathway affecting stem cell differentiation, this kind of treatment is really simple, but blind. For example, what will the effect of all those extraction, culturing and IV injection procuders will be on the human SSCs? Some can argue that the current situation of stem cell field is premature for this kind of experiment.
there are several hypothesis about this: why don't humans have regenarative powers? the answer might be that there was never a selective pressure to develop one. in the wilderness if you lose a limb, you are practically dead. so regenerating it does not make sense, there is no selective pressure for it. higher vertebrates mostly lack regeneration potential of lower complexity organisms. regeneration is thougth to be coupled with increased possibility of cancer, so this might be a sensible trade-off. there is an interesting salamander called axolotl that can grow whole limbs and is currently being studied as a model organism for regeneration studies. in their natural habitat, they lose limbs very often so the ability to grow them back is a useful one. natural selection might have favored them to keep regeneration of this level. (http://www.centralpets.com/animals/reptiles/salam anders/sal2539.html/)
Fascinating. In summary, this article shows that tumor cells of widely different genetic backgrounds share a common behavior. When tumors grow in vitro, this behavior is completely compatible with MBE universality dynamics. Further, there is sufficiently abundant and clear biological and clinical evidence to suggest that this is also the case in vivo, although further work is needed to confirm this. In any case, a universal tumor growth dynamics is observed for any type of tumor in vivo, independently of any other characteristic of tumoral cell lines. This dynamics is always governed by processes of cell surface diffusion. However, more work is needed to fully determine the whole dynamical behavior of tumor growth. The fractality of the contour of all the studied cell colonies and tumors has been demonstrated. Scaling techniques show that in vitro and in vivo cell proliferation would obey the same dynamics, independent of cell line or any other characteristic. These universal dynamics are compatible with a linear growth regime, a result in contrast with the currently accepted exponential or Gompertzian models of tumor growth. The main mechanism responsible for tumor progression, as for any cell proliferation process, is cell diffusion on the tumor border. These results incorporate the new concept that the major conditioner of tumor growth is space competition between tumor and the host, which is more important than nutrient competition or angiogenesis, etc. The latter must be considered, in some cases, as necessary or as a coadjuvant condition of tumor growth, but their effects mainly consist of modifying the growth rate--perhaps simply allowing it or not. These results invalidate the current concept of cell proliferation and offer a unified view of tumor development. The dynamics involved provide coherent explanations where the traditional model cannot. Despite the importance of characteristics common to the dynamics of the in vivo growth of different tumors, more work is needed to completely characterize them. It should not be forgotten that, independent of interpretations, this article shows for the first time that different tumors have common characteristics such as the distribution of cell proliferation and their characteristic forms (that would imply common basic growth processes), determined via the critical exponents of local and global roughness. As a result, some important features of cancer can be better explained. Moreover, some clinical strategies may need to be revised.
Fill a law suit against Sony. I would love to be at the hearings.
Hope we don't find them, or something like them...
Exactly what I felt while I was crawling the fucking corridors your engine rendered...
I hear you. Hey, FBI! Target Me!
Now they tried NBA! http://www.evilavatar.com/modules.php?op=modload&n ame=News&file=article&sid=7277&mode=thread&order=0 &thold=0
I found generation 24, but when I clicked the link a normal site appeared. it seems that a quick fix does the trick.
Manhunt playing kids getting murdered!
When will it be available?
Interesting. You could say that, these beneficial bacteria of the intestinal tract may not be affected from a loss of communication from fellow bacteria, while at the same time the pathogenic bacteria will stop producing toxins and eventually will be overcome by body's natural defenses. But, this is pure speculation; the case is too complex and will be solved by animal experiments. This looks promising, solely because it does not cause a major selection pressure on bacteria as a killer antibiotic.
He is from Istanbul, and I am a Turk. Careful.
I got quickly sick of Robert Jordan's The Wheel of Time series. It is the lineage II of fantasy literature.
Are suggested reading for any SF fan. Very strong stories, certainly thougt-provoking.
play World of Warcraft for 1000 years!
Imagine the possibilities! With a limitless supply of stem cells, you can create actual, adapting human brain in a lab enviroment! I am definitly going to try this! But I think I have to go Saudi arabia or any other desolate place..
In this case, prions are causing the yeast cells to make slightly varied proteins. when they are exposed to stress conditions, some very very few of these infected yeasts gain a more efficient way of survival because of this pre-adaptation, thus by having the upper hand in the competition for limited resources, they are selected for survival. this effect is very similar to any kind of mutagens (mutation causing agents), in fact the main test to determine the potential of a chemical to cause cancer is working with a similar principle. so, to sum it up, they found out that prions can enhance mutation rate (not sure about this, is it really a permanent mutation which is inheritable or an error of post translational mechanism?) of yeasts. so, I don't see a big revolutionary discovery, just a novel discovery of an evolutionary mechanism.