"But the lining of the nose and cheeks are loaded with pepper receptors, and anyone who ground up such a pill would get a burning feeling in the chest, face, rectum and extremities, as well as paroxysmal coughing" (emphasis mine)
Are you kidding me, pepper receptors!?!?
Capsaicin works by approximating the effect of neurotransmitters at regular pain receptors. The human body doesn't have any 'pepper receptors.'
One of the responses to capsaicin is mild euphoria, similar to a runner's high, induced by the body's reaction to pain. I'm not sure a lot of junkies wouldn't welcome the additive effects:)
"What about people with involuntary acid reflux, or vomiting? If the capsaicin is released in the stomach, this could have horrible consequences even for those who take the pill as intended. I think the opiate antagonist is a MUCH better idea."
Well, that's one thing doctors are for... to decide what drug is appropriate for the patient and their condition. For any patient with GERD or vomiting, capsaicin-laced painkillers would be contraindicated.
It's not crushed because of time-release; it's crushed because of the absorption rate of the drug through the nasal membranes vs through the GI tract.
Also, drugs absorbed intranasally don't go through first-pass metabolism, where up to about 20% of the drug is metabolized by the liver as it passes through the GI tract.
FTS: "The gaming world hyped the tour as proof that pro gaming is on its way to being recognized as a pro sport. I'll believe it when I stop seeing so many pudgy male groupies. "
How does the fan base affect whether or not something is a professional sport?
Is it a competition? Do the participants make enough money to make it their primary source of income, whether directly (prizes) or indirectly (sponsorship deals)? If the answer is yes to both of those, then it's a professional sport. The breakthrough is when the participants make enough money at it to fully support themselves.
It's not like 'the gaming world' is claiming that pro gaming is on its way to becoming a professional sport with an all-inclusive audience.
Also, re: the pudgy male groupies: have you looked at the average spectator at an NFL game? The biggest difference here is age, not gender or weight.
FTS:"Despite that level of success, Microsoft is still disappointed with production levels and sales."
If you meet your goals, but are disappointed with your sales... that means your goals are too low.
Goals should be set at a level where you aren't diappointed with your results when you attain them.
Of course, from a PR perspective, you've got to set goals that you can't miss -- otherwise you're a goat to the public. Your future sales, as well as your market cap, will reflect poor performance.
What MS should be saying, is that they are meeting their expectations, but sales are falling short of their real targets (their goals).
" Shouldn't it be where water exists on the borderline between gas and solid?"
No. Liquid water doesn't exist at the temp and pressure where there is a borderline between gas and solid, you get direct sublimation from solid to gas under those conditions -- unless you happen to be at exactly the triple point.
Conversion between gas and liquid would help in the formation of life precursors, since the phase changes could help concentrate compounds in acqueous solution, resulting in greater rates of reaction. I'm sure there are other reasons why acqueous phase changes would help formation of complex organic molecules.
"I'm not too sure about the "hard work" either, it seems the industry just substitutes thought and actual work with a big wad of cash to make shiny special effects."
What about all the people working hard to produce those special effects? The artists making 40k, working 80 hours a week, to get the CGI up to spec on deadline?
As a shareholder, he's got the right to be heard, if the board gives him the floor. I truly hope they don't, since his points are almost definitely not germane to the purpose of the meeting. I'd like to see the rules governing shareholder meetings at Take-two.
If he really wants to be heard, he should buy a controlling stake in the company... not that he could afford it.
Anyone know if Ryan's a majority shareholder? He'd put JT in his place so fast, Thompson wouldn't know up from down, left from right, A from B, B from A, Select from Start.
"Unemployment is down, the economy is booming, we haven't had a terrorist attack since 9/11, and we are continuing to strive through disasters such as Katrina"
"Unemployment is down"
So are wages adjusted for inflation.
"the economy is booming" Umm, no. The economy has posted modest gains offset by inflation (just wait until figures come out for Q1 2006) and leveraged by massive amounts of debt, which WILL need to be paid back.
"we haven't had a terrorist attack since 9/11"
Not relevant, unless you can prove one or more have been thwarted by the PATRIOT Act, that wouldn't have been thwarted otherwise.
"we are continuing to strive through disasters such as Katrina." Strive? So, struggling is the definition of success? Besides, it didn't seem to me like FEMA was striving for anything in the immediate aftermath of Katrina. Just plain old suffering though a disaster means we're doing well?
Take a look at the long term. Open your eyes. Things are NOT good. Things will be WORSE soon, due to current policies. What is freedom worth to you, anyway -- a false sense of security?
"Something similar was done with Enigma. The fact that Enigma had been cracked was kept very quiet so that Enigma machines could be sold by the Brits to foreign governments after the war and we could listen in!"
No, that's not why it was kept quiet. It was kept quiet because otherwise the crack was useless in the war.
Please don't take history lessons from pop movies (Enigma, 2001). The movie Enigma was full of inaccuracies and half-truths.
Also, please don't take it from sci-pop literature (Neal Stephenson, e.g.) -- also not accurate.
Just wanted to add, that I specifically pointed out that I was lookng for other reasons in my OP. I'm fully aware of how that validates interest in him.
"Earlier computer systems were even more primitive and being operated NOT by MIT graduates but by a girl promoted from the typing pool. For that matter how do you think the earliest word processors and such worked? Point and click? Nor were they being used by harvard graduates. Just girls with barely a diploma in home economics."
Been reading too much Stephenson, sir?
Operation of early computer systems was much simpler than those of today. The primary requisite was attention to detail when faced with monotonous tasks. Time and again, it has been shown that the most intelligent people are some of the least able to do this well.
It's all about picking people with strengths suited to their roles. The same goes with OSs -- it's about picking an OS that fits your company.
Also, not to belabor the point, but the GP was exaggerating to make a point about the difficulties of *nix operation -- and was also not just talking about corporate situations. Sure, you hire people with average or higher intelligence who also are computer literate -- but what about all the users who are new to computing or below average intelligence?
For me, it's about potential. In my OP, I was careful to make the distinction that I wanted to know what reasons other than CR's championing of the cause justified more attention to him than to the thousands of people out of the public eye.
If anything, it's the other people who need to be publicized -- people need to be reminded that it's not just victims of polo accidents who would like a cure to paralysis.
Re: saving a child vs. saving an adult (if faced with the choice), it's mostly about potential to me. When in doubt, I'd try to save the person with a whole life possibly ahead of them in most situations. The logic is that the unknown potential of the child's life may be phenomenal -- and we lose out on that possibility if we choose the older person. I know, greatest good and all that, and the doctor you mention probably saves more lives via his own work thanthe one baby saved. But I would think that rarely in life are such choices so obvious.
I appreciate everything he did for the cause, but I think the link to his webpage was gratuitous link-pimping on the part of TMM, and we could have been better served by links to unsung heroes/victims of the cause.
I can appreciate the man, and yes, I wish he could have seen what his efforts have helped come about. But I think that by focusing so much on him, people lose sight of all the other people (particularly children, who are the most easily helped by therapies like that of the trials in TFA) who have lost their lives and/or a lot of functional capacity to brain and nerve damage.
Sure. But Christopher Reeve had already accomplished almost everything he was going to accomplish in his life. He wasn't a champion of any cause prior to his injury, he was just a fading pop culture icon.
In terms of who we should be sorry wasn't saved, I'd trade one child for Christopher Reeve any day.
Yes, some weirdos 'hijacked' it decades, possibly even centuries ago.
I don't know how you can complain about mutability of language, when you use the word 'hijacked' in a different-than-original meaning, mispelled 'weirdos,' and forgot your apostrophe in 'isn't.' Never mind the fact that contractions are a bastardization of language anyway...
"...it's a real pity that Christopher Reeve [chrisreevehomepage.com] had to leave us before we made these advances."
Why? What makes an actor who played a comic book hero worthy of mention (other than the fact that he championed the cause), instead of the thousands of children who were and are never able to realize their potential?
Slashdot Mirror
"But the lining of the nose and cheeks are loaded with pepper receptors, and anyone who ground up such a pill would get a burning feeling in the chest, face, rectum and extremities, as well as paroxysmal coughing" (emphasis mine)
:)
Are you kidding me, pepper receptors!?!?
Capsaicin works by approximating the effect of neurotransmitters at regular pain receptors. The human body doesn't have any 'pepper receptors.'
One of the responses to capsaicin is mild euphoria, similar to a runner's high, induced by the body's reaction to pain. I'm not sure a lot of junkies wouldn't welcome the additive effects
"What about people with involuntary acid reflux, or vomiting? If the capsaicin is released in the stomach, this could have horrible consequences even for those who take the pill as intended. I think the opiate antagonist is a MUCH better idea."
Well, that's one thing doctors are for... to decide what drug is appropriate for the patient and their condition. For any patient with GERD or vomiting, capsaicin-laced painkillers would be contraindicated.
It's not crushed because of time-release; it's crushed because of the absorption rate of the drug through the nasal membranes vs through the GI tract.
Also, drugs absorbed intranasally don't go through first-pass metabolism, where up to about 20% of the drug is metabolized by the liver as it passes through the GI tract.
FTS: "The gaming world hyped the tour as proof that pro gaming is on its way to being recognized as a pro sport. I'll believe it when I stop seeing so many pudgy male groupies. "
How does the fan base affect whether or not something is a professional sport?
Is it a competition? Do the participants make enough money to make it their primary source of income, whether directly (prizes) or indirectly (sponsorship deals)? If the answer is yes to both of those, then it's a professional sport. The breakthrough is when the participants make enough money at it to fully support themselves.
It's not like 'the gaming world' is claiming that pro gaming is on its way to becoming a professional sport with an all-inclusive audience.
Also, re: the pudgy male groupies: have you looked at the average spectator at an NFL game? The biggest difference here is age, not gender or weight.
FTS:"Despite that level of success, Microsoft is still disappointed with production levels and sales."
If you meet your goals, but are disappointed with your sales... that means your goals are too low.
Goals should be set at a level where you aren't diappointed with your results when you attain them.
Of course, from a PR perspective, you've got to set goals that you can't miss -- otherwise you're a goat to the public. Your future sales, as well as your market cap, will reflect poor performance.
What MS should be saying, is that they are meeting their expectations, but sales are falling short of their real targets (their goals).
" Shouldn't it be where water exists on the borderline between gas and solid?"
No. Liquid water doesn't exist at the temp and pressure where there is a borderline between gas and solid, you get direct sublimation from solid to gas under those conditions -- unless you happen to be at exactly the triple point.
Conversion between gas and liquid would help in the formation of life precursors, since the phase changes could help concentrate compounds in acqueous solution, resulting in greater rates of reaction. I'm sure there are other reasons why acqueous phase changes would help formation of complex organic molecules.
"What happens when you _have_ all the world's information indexed? "
You sell it. Or you use it to sell something else (like ad delivery). Hence, maximize shareholder profits.
You're right though, it's kind of scary to have so much power centrally administered.
My point was that the OP was implying that CGI doesn't require any hard work, that's all.
"I'm not too sure about the "hard work" either, it seems the industry just substitutes thought and actual work with a big wad of cash to make shiny special effects."
What about all the people working hard to produce those special effects? The artists making 40k, working 80 hours a week, to get the CGI up to spec on deadline?
" As a shareholder, doesn't he have the responsibility to do what's best for the company? "
No, not at all. As a shareholder, all he has to do is what he thinks is best for him.
Officers of the corp, executives, management? Different story.
Because flamewar = page views ~= revenue.
Slashdot is a business.
Plus, some people enjoy flaming Dvorak. It makes them feel superior, and every nerd needs an ego-massage once in a while (myself included).
Barking up the wrong tree.
As a shareholder, he's got the right to be heard, if the board gives him the floor. I truly hope they don't, since his points are almost definitely not germane to the purpose of the meeting. I'd like to see the rules governing shareholder meetings at Take-two.
If he really wants to be heard, he should buy a controlling stake in the company... not that he could afford it.
Anyone know if Ryan's a majority shareholder? He'd put JT in his place so fast, Thompson wouldn't know up from down, left from right, A from B, B from A, Select from Start.
When did I extrapolate my behaviour to others? Look at the parent to your post...
There were no generalizations about everyone. There was just info about how I feel about it.
"If we lose liberties present in The Constitution, The Amendments and The Bill of Rights, have the terrorists won?"
No, but we've lost. The only winners are the symbiotic politician/military-industrial complexes.
"Unemployment is down, the economy is booming, we haven't had a terrorist attack since 9/11, and we are continuing to strive through disasters such as Katrina"
"Unemployment is down"
So are wages adjusted for inflation.
"the economy is booming"
Umm, no. The economy has posted modest gains offset by inflation (just wait until figures come out for Q1 2006) and leveraged by massive amounts of debt, which WILL need to be paid back.
"we haven't had a terrorist attack since 9/11"
Not relevant, unless you can prove one or more have been thwarted by the PATRIOT Act, that wouldn't have been thwarted otherwise.
"we are continuing to strive through disasters such as Katrina."
Strive? So, struggling is the definition of success? Besides, it didn't seem to me like FEMA was striving for anything in the immediate aftermath of Katrina. Just plain old suffering though a disaster means we're doing well?
Take a look at the long term. Open your eyes. Things are NOT good. Things will be WORSE soon, due to current policies. What is freedom worth to you, anyway -- a false sense of security?
"Something similar was done with Enigma. The fact that Enigma had been cracked was kept very quiet so that Enigma machines could be sold by the Brits to foreign governments after the war and we could listen in!"
No, that's not why it was kept quiet. It was kept quiet because otherwise the crack was useless in the war.
Please don't take history lessons from pop movies (Enigma, 2001). The movie Enigma was full of inaccuracies and half-truths.
Also, please don't take it from sci-pop literature (Neal Stephenson, e.g.) -- also not accurate.
Just wanted to add, that I specifically pointed out that I was lookng for other reasons in my OP. I'm fully aware of how that validates interest in him.
Might as well toss in that involves cruelty to animals (according to some people).
"Earlier computer systems were even more primitive and being operated NOT by MIT graduates but by a girl promoted from the typing pool. For that matter how do you think the earliest word processors and such worked? Point and click? Nor were they being used by harvard graduates. Just girls with barely a diploma in home economics."
Been reading too much Stephenson, sir?
Operation of early computer systems was much simpler than those of today. The primary requisite was attention to detail when faced with monotonous tasks. Time and again, it has been shown that the most intelligent people are some of the least able to do this well.
It's all about picking people with strengths suited to their roles. The same goes with OSs -- it's about picking an OS that fits your company.
Also, not to belabor the point, but the GP was exaggerating to make a point about the difficulties of *nix operation -- and was also not just talking about corporate situations. Sure, you hire people with average or higher intelligence who also are computer literate -- but what about all the users who are new to computing or below average intelligence?
For me, it's about potential. In my OP, I was careful to make the distinction that I wanted to know what reasons other than CR's championing of the cause justified more attention to him than to the thousands of people out of the public eye.
If anything, it's the other people who need to be publicized -- people need to be reminded that it's not just victims of polo accidents who would like a cure to paralysis.
Re: saving a child vs. saving an adult (if faced with the choice), it's mostly about potential to me. When in doubt, I'd try to save the person with a whole life possibly ahead of them in most situations. The logic is that the unknown potential of the child's life may be phenomenal -- and we lose out on that possibility if we choose the older person. I know, greatest good and all that, and the doctor you mention probably saves more lives via his own work thanthe one baby saved. But I would think that rarely in life are such choices so obvious.
'Don't play God!'
Why not? He/she's doing such a crapy job anyway."
Exactly. I play to win, and given God's omniscience, I wouldn't play God at any game unless s/he wasn't playing up to potential.
My frag rate is sick, but God's must be... well... God-like.
I appreciate everything he did for the cause, but I think the link to his webpage was gratuitous link-pimping on the part of TMM, and we could have been better served by links to unsung heroes/victims of the cause.
I can appreciate the man, and yes, I wish he could have seen what his efforts have helped come about. But I think that by focusing so much on him, people lose sight of all the other people (particularly children, who are the most easily helped by therapies like that of the trials in TFA) who have lost their lives and/or a lot of functional capacity to brain and nerve damage.
Sure. But Christopher Reeve had already accomplished almost everything he was going to accomplish in his life. He wasn't a champion of any cause prior to his injury, he was just a fading pop culture icon.
In terms of who we should be sorry wasn't saved, I'd trade one child for Christopher Reeve any day.
Yes, some weirdos 'hijacked' it decades, possibly even centuries ago.
I don't know how you can complain about mutability of language, when you use the word 'hijacked' in a different-than-original meaning, mispelled 'weirdos,' and forgot your apostrophe in 'isn't.' Never mind the fact that contractions are a bastardization of language anyway...
"...it's a real pity that Christopher Reeve [chrisreevehomepage.com] had to leave us before we made these advances."
Why? What makes an actor who played a comic book hero worthy of mention (other than the fact that he championed the cause), instead of the thousands of children who were and are never able to realize their potential?