"Published negative studies dissuade doctors from using certain offlabel treatments. Published negative studies prevent other docs from wasting time and money to discover the same results."
This is my gut reaction to reading TFA. I understand that in a sense, this isn't new news. Some of the commenters have talked about the time and cost associated with organizing and publishing negative/unintended results. However, from a scientific point of view, this seems like the single most important reason to publish that data; to allow other scientists to both learn from other's mistakes and improve on said mistakes if possible.
Actually, I'm wondering about a slightly different mutation. The full article (http://www.sciencedaily.com/releases/2008/04/080415101021.htm) mentions that the water reached temperatures of 55,000 degrees F at the time of the explosion.
Would the surviving corals from such extreme temperatures gain an adaptation to higher water temperatures? I mention it because there was another related article about how areas where varying temperatures exist might create corals more resistant to bleaching:
http://www.sciencedaily.com/releases/2007/11/071129183829.htm
I'm just picturing the human race rapidly increasingly evolution of coral by raising the water temperatures to the extremes associated with atomic explosions. I'm no evolution expert but am curious if such a thing could occur?
The applet automatically adjusts the time to "local time". When
you plug in Denver for the 10 Quad 02:00, you'll notice at the
bottom of the graph that it's adjusted to GMT -7. Just under
and to the left, it says your peak is 04:16 local time in
the countryside. So you don't have to make any further time
adjustments. The applet does that for you when you select
your city.
Whether customers may copy their CDs onto their computers -- an act at the very
heart of the digital revolution -- has a murky legal foundation, the RIAA argues.
The industry's own Web site says that making a personal copy of a CD that you bought
legitimately may not be a legal right, but it "won't usually raise concerns," as
long as you don't give away the music or lend it to anyone.
Yes, yes... there's all the talk about fair use, but this statement just strikes me
as them trying to enforce a standard that wasn't a standard. It may have been
considered by them not to "be a legal right" to copy but they rarely bothered
to enforce it. Now that the business model is collapsing, they start to enforce
this so-called standard?
You know, each person has their own breaking point, and if this is the newest
trend of the RIAA, then I've just reached my own breaking point. I've had it.
I'm done with them. Period. I can't take being forced this rotten tripe they and
their associates have been feeding the people. "from the because-we-needed-
another-reason-to-be-cranky-at-them dept" indeed.
An image that particularly stood out for me was this one:
http://www.flickr.com/photo_zoom.gne?id=2059045060&size=o
Simply... fantastic! I love science fiction but haven't read
much pulp material. This theme of combining the electronic
with the organic... was it that prevelant in the '50s? I haven't
seen a lot of art like this. The only thing that even comes
close in my memory is perhaps some of the old War of the Worlds
related art:
http://drzeus.best.vwh.net/wotw/0009.html
Cool stuff.
Not sure of the "when", but their website states...
Please sign up here to be notified of our upcoming public product launch www.nanosolar.com
MY question is about the practical side of it. How do
install it? If you cut it to size, how do you "seal" the
end where you cut it? How do you connect each length to
the grid of the apparatus to be powered? Guess we'll find
out soon enough.
I'm not a child psychologist or anything... but it seems slightly strange
to hear speculation that a character like Oscar couldn't be included in
a modern Seasame Street. Ok... I understand the idea that a young developing
mind could perhaps grasp on to mannerisms and take them for themself (or
perhaps mimic the behaviour).
But what does the removal of a grouchy (or overeating, obsessive, overly
joyous, etc.) character accomplish? Perhaps my memory is a bit fuzzy, but
didn't Sesame Street show methods of dealing with a grouchy (or overeating,
etc., etc.,) character? Wasn't it helpful as a mechanism to explain that not
only these types of personalities exist, but also how to appropriately
interact with them? Or is this just one negative affect (the "positive"
effect arguably that you remove an "unhealthy" role model)?
Flamebait? How does this get modded "Flamebait"?
While I don't agree completely with the author,
the statement "Define win" is absolutely valid.
Normally in a board game, the winning conditions
are defined with some goal. While war is completely
far removed from a board game, a war usually has a goal
or many goals by the participants. What's our goal(s) in
Iraq at this point? Wasn't it officially to change
the regime? Then what? No... "define win" is still valid
at this point.
Much like the belief that the U.S. economy will continue to only grow, how much of this
is Apple executives putting unrealistic faith into the idea that iPod sales will continue
to grow? I'm not an economics major (so perhaps someone will elaborate here), but it
seems intuitive that it's unrealistic to believe in growth forever, especially in an item
that (as has been mentioned) is mostly commonplace and dare I say... mundane.
-ShawnD
I wonder if this guy know how much of a pain in the ass it is to collect
money from a small claims case where the defendant doesn't bother to
show up? Granted, there are a number of options at his disposal, but most
require knowing a lot of details about the defendant. Garnish his wages?
Where does he work and how do you find out? Put a lien on the defendant's
property? You have to find out more info on the assets of the defendant.
My personal experience was that you had to be (or hire a) private detective
to even collect on a dead beat defendant.
This guy sounds tenacious though. We'll see how long it takes for him to
actually collect the money.
-ShawnD
So yeah, Nintendo hasn't done a lot with RPG since the SNES.
While Wii seems like it will support most of the old RPG titles
(via a fee-based download service), what about future titles?
Yes yes... FF : Crystal Chronicles or Crystal Bearers or what not.
But Chronicles really wasn't turn-based RPG. Is RPG relegated
to the other consoles these days? Or am I being incredibly naive?
just how large a portion of fossils are dated that way?
The potassium-argon (K-Ar) or rubidium-strontium (Rb/Sr) methods are
the ones usually reserved for strata older than 100,000 years old. Yes,
these methods are more expensive than C-14. The limitation of
course is the half-life of the C-14, causing it to be primarily
feasible for more recent strata/items. What percentage of dig-
sites are dated using K-Ar or Rb/Sr? I don't know.
As for claiming that the fossil evidence isn't "all that grand",
I wouldn't use this article as evidence. I will say that the stated
"differences" of "age" found when using amino acid comparison and
using radiometric dating are interesting. More testing will be performed
and theories suggested. Time will tell if either method is more accurate.
In the grand scheme of fossil evidence, yes, an amazing abundance of
creatures shares generalized features like "feet", "limbs", and other
body parts. (As soft tissues such as eyes and livers usually didn't
survive the ages, I leave them out.) However, the point is that if
one takes this body of fossil evidence and puts it in the best chrono-
logical order possible, an "evolution" of those "feet" and "limbs"
creates a convincing theory.
If you're not one to believe in potassium-argon or rubidium-strontium
methods of dating ancient fossils, then I'll end my debate here.
All bodies with a desire to fund such research should consider their point well made and redirect the funds into lobbying governments for population resettlement plans if they believe in their own research to date.
More like "population reduction" plans. Less land, more people? Oh wait; that's what disease is for, correct? Feh. If disease and famine don't do the trick, what will?
I have noticed in my behavior and that of many other males, that we are being less like men, and that is simply unnatural.
Based on your limited experience and preconceptions of gender roles, I suppose so, but the fact remains that most of these gender roles are socially imposed. Unnatural doesn't really apply to something like that.
And this was going to be my point earlier; however, I wanted to get an explanation of Hackstraw's statement before debating. It's a solid fact that gender roles are often imposed by society. After all, it's easier and more "kind" for a family to have their baby boy wearing blue than pink. It's easier and more "kind" to encourage their daughter to engage in tasks that are passively home-based rather than actively political-based. If parents encourage activities that are streamline, at least their son or daughter won't have to suffer through humiliation growing up! I can't speak for every person that's felt like an outcast because they broke away from socially "accepted" standards. I would venture to say, though, that I'd rather have my parent's support of my "non-standard" gender practices while growing up rather than being forced to fit social standard.
If one is a conservative and wishes to stick to old standard, I won't stop you. Until people all over realize that the social definition of gender is truly blurred, they will continue to enforce social standards, whether it's through the raising of their children or by laughing at and/or beating up a male because he's wearing a skirt.
I agree that though intended to be "humour", it has to be recognized that there are people that think that way in the programming industry. Not to start flaming, but I've always maintained that the expansive hard drive sizes over the years certainly hasn't aided in the idea of creating (and maintaining) tight, clean code. Yes, the topic has been beat around a lot; however, it's perfectly valid. I certainly I have spoken to more than a few long-time programmers that - though not outright - have indicated that the leaps in hard drive space gave more than a little breathing room in software development. -Shawn
Ok. Let me preface this by saying that I probably
wouldn't recommend keeping an unsecured text file full
of passwords and financial data.
That said, in theory, could the same concept be applied
by creating such a text file, say on a laptop you never
connect to the internet, saving to floppy and then opening
the file from the floppy on your desktop. When you want to
enter such data, open the file, copy-paste. Would this accomplish
the same thing? I'm ignorant to the concept really. Thanks.
Ok. I'll bite. I've been using Opera as an alternative to IE
for two years now (in conjunction with Ad-Aware, Spybot, and AVG).
For a few websites, I still had to use IE last year but it seems
that Opera has become supported enough that with the updates, I
don't hardly ever need to use another browser.
I can't say that I've investigated Firefox much at all. Where
does Firefox rank security-wise with your Operas and other
alternative browsers?
How many other bacteria affect humans in similar methods
where inhalation is deadlier than skin contact? Just curious
if the same premise of narrowing down why one exposure is
less lethal than another could be applied to other bacteria.
Slashdot Mirror
"Published negative studies dissuade doctors from using certain offlabel treatments. Published negative studies prevent other docs from wasting time and money to discover the same results."
This is my gut reaction to reading TFA. I understand that in a sense, this isn't new news. Some of the commenters have talked about the time and cost associated with organizing and publishing negative/unintended results. However, from a scientific point of view, this seems like the single most important reason to publish that data; to allow other scientists to both learn from other's mistakes and improve on said mistakes if possible.
Actually, I'm wondering about a slightly different mutation. The full article (http://www.sciencedaily.com/releases/2008/04/080415101021.htm) mentions that the water reached temperatures of 55,000 degrees F at the time of the explosion. Would the surviving corals from such extreme temperatures gain an adaptation to higher water temperatures? I mention it because there was another related article about how areas where varying temperatures exist might create corals more resistant to bleaching: http://www.sciencedaily.com/releases/2007/11/071129183829.htm I'm just picturing the human race rapidly increasingly evolution of coral by raising the water temperatures to the extremes associated with atomic explosions. I'm no evolution expert but am curious if such a thing could occur?
Flash! AHHHHHH! He'll save every one of us!
Flash Gordon Intro
Too bad it cuts out before the beginning of the meteor storm.
The applet automatically adjusts the time to "local time". When
you plug in Denver for the 10 Quad 02:00, you'll notice at the
bottom of the graph that it's adjusted to GMT -7. Just under
and to the left, it says your peak is 04:16 local time in
the countryside. So you don't have to make any further time
adjustments. The applet does that for you when you select
your city.
Yes, yes... there's all the talk about fair use, but this statement just strikes me
as them trying to enforce a standard that wasn't a standard. It may have been
considered by them not to "be a legal right" to copy but they rarely bothered
to enforce it. Now that the business model is collapsing, they start to enforce
this so-called standard?
You know, each person has their own breaking point, and if this is the newest
trend of the RIAA, then I've just reached my own breaking point. I've had it.
I'm done with them. Period. I can't take being forced this rotten tripe they and
their associates have been feeding the people. "from the because-we-needed-
another-reason-to-be-cranky-at-them dept" indeed.
An image that particularly stood out for me was this one: http://www.flickr.com/photo_zoom.gne?id=2059045060&size=o Simply... fantastic! I love science fiction but haven't read
much pulp material. This theme of combining the electronic
with the organic... was it that prevelant in the '50s? I haven't
seen a lot of art like this. The only thing that even comes
close in my memory is perhaps some of the old War of the Worlds
related art: http://drzeus.best.vwh.net/wotw/0009.html Cool stuff.
MY question is about the practical side of it. How do
install it? If you cut it to size, how do you "seal" the
end where you cut it? How do you connect each length to
the grid of the apparatus to be powered? Guess we'll find
out soon enough.
I'm not a child psychologist or anything... but it seems slightly strange
to hear speculation that a character like Oscar couldn't be included in
a modern Seasame Street. Ok... I understand the idea that a young developing
mind could perhaps grasp on to mannerisms and take them for themself (or
perhaps mimic the behaviour).
But what does the removal of a grouchy (or overeating, obsessive, overly
joyous, etc.) character accomplish? Perhaps my memory is a bit fuzzy, but
didn't Sesame Street show methods of dealing with a grouchy (or overeating,
etc., etc.,) character? Wasn't it helpful as a mechanism to explain that not
only these types of personalities exist, but also how to appropriately
interact with them? Or is this just one negative affect (the "positive"
effect arguably that you remove an "unhealthy" role model)?
Any child psychologists in the house?
Flamebait? How does this get modded "Flamebait"? While I don't agree completely with the author, the statement "Define win" is absolutely valid. Normally in a board game, the winning conditions are defined with some goal. While war is completely far removed from a board game, a war usually has a goal or many goals by the participants. What's our goal(s) in Iraq at this point? Wasn't it officially to change the regime? Then what? No... "define win" is still valid at this point.
Much like the belief that the U.S. economy will continue to only grow, how much of this is Apple executives putting unrealistic faith into the idea that iPod sales will continue to grow? I'm not an economics major (so perhaps someone will elaborate here), but it seems intuitive that it's unrealistic to believe in growth forever, especially in an item that (as has been mentioned) is mostly commonplace and dare I say ... mundane.
-ShawnD
I wonder if this guy know how much of a pain in the ass it is to collect money from a small claims case where the defendant doesn't bother to show up? Granted, there are a number of options at his disposal, but most require knowing a lot of details about the defendant. Garnish his wages? Where does he work and how do you find out? Put a lien on the defendant's property? You have to find out more info on the assets of the defendant. My personal experience was that you had to be (or hire a) private detective to even collect on a dead beat defendant. This guy sounds tenacious though. We'll see how long it takes for him to actually collect the money. -ShawnD
So yeah, Nintendo hasn't done a lot with RPG since the SNES.
While Wii seems like it will support most of the old RPG titles
(via a fee-based download service), what about future titles?
Yes yes... FF : Crystal Chronicles or Crystal Bearers or what not.
But Chronicles really wasn't turn-based RPG. Is RPG relegated
to the other consoles these days? Or am I being incredibly naive?
...stays in China.
This message brought to you by the Chinese Tourist Board.
-Shawn
just how large a portion of fossils are dated that way?
The potassium-argon (K-Ar) or rubidium-strontium (Rb/Sr) methods are
the ones usually reserved for strata older than 100,000 years old. Yes,
these methods are more expensive than C-14. The limitation of
course is the half-life of the C-14, causing it to be primarily
feasible for more recent strata/items. What percentage of dig-
sites are dated using K-Ar or Rb/Sr? I don't know.
As for claiming that the fossil evidence isn't "all that grand",
I wouldn't use this article as evidence. I will say that the stated
"differences" of "age" found when using amino acid comparison and
using radiometric dating are interesting. More testing will be performed
and theories suggested. Time will tell if either method is more accurate.
-Shawn
Dear Mr/Ms Facetious,
In the grand scheme of fossil evidence, yes, an amazing abundance of
creatures shares generalized features like "feet", "limbs", and other
body parts. (As soft tissues such as eyes and livers usually didn't
survive the ages, I leave them out.) However, the point is that if
one takes this body of fossil evidence and puts it in the best chrono-
logical order possible, an "evolution" of those "feet" and "limbs"
creates a convincing theory.
If you're not one to believe in potassium-argon or rubidium-strontium
methods of dating ancient fossils, then I'll end my debate here.
-Shawn
Here's a brief technical look at the theory by the University of California - Berkeley's
Museum of Paleontology : http://www.ucmp.berkeley.edu/diapsids/avians.html
Of interest are twenty proposed characteristics "the first birds shared [...] with
many coelurosaurian dinosaurs." Take a look and see what you think.
-Shawn
All bodies with a desire to fund such research should consider their
point well made and redirect the funds into lobbying governments for
population resettlement plans if they believe in their own research to date.
More like "population reduction" plans. Less land, more people? Oh wait;
that's what disease is for, correct? Feh. If disease and famine don't
do the trick, what will?
And this was going to be my point earlier; however, I wanted to get an explanation
of Hackstraw's statement before debating. It's a solid fact that gender roles are often
imposed by society. After all, it's easier and more "kind" for a family to have their
baby boy wearing blue than pink. It's easier and more "kind" to encourage their daughter
to engage in tasks that are passively home-based rather than actively political-based.
If parents encourage activities that are streamline, at least their son or daughter won't
have to suffer through humiliation growing up! I can't speak for every person that's
felt like an outcast because they broke away from socially "accepted" standards. I would
venture to say, though, that I'd rather have my parent's support of my "non-standard" gender
practices while growing up rather than being forced to fit social standard.
If one is a conservative and wishes to stick to old standard, I won't stop you. Until
people all over realize that the social definition of gender is truly blurred, they
will continue to enforce social standards, whether it's through the raising of their
children or by laughing at and/or beating up a male because he's wearing a skirt.
"Western society is getting so feminized"
Before I jump to conclusions, could you please further
elaborate on your meaning with this statement?
I agree that though intended to be "humour", it has to be recognized
that there are people that think that way in the programming industry.
Not to start flaming, but I've always maintained that the expansive
hard drive sizes over the years certainly hasn't aided in the idea of
creating (and maintaining) tight, clean code. Yes, the topic has been
beat around a lot; however, it's perfectly valid. I certainly I have
spoken to more than a few long-time programmers that - though not
outright - have indicated that the leaps in hard drive space gave more
than a little breathing room in software development.
-Shawn
I identify with that statement well. Even with a fancy "College Preparatory" certificate,
I was not prepared for the studying required to get through college. If I could get "A's"
and a "B" or two without even trying, what incentive did I have to learn good study habits?
It seems to me that part of that College Prep certificate should have required a class about
good study habits. But then again, if one could pass the "Study habits" class without
studying... errr. Yeah.
-Shawn
Ok. Let me preface this by saying that I probably wouldn't recommend keeping an unsecured text file full of passwords and financial data.
That said, in theory, could the same concept be applied by creating such a text file, say on a laptop you never connect to the internet, saving to floppy and then opening the file from the floppy on your desktop. When you want to enter such data, open the file, copy-paste. Would this accomplish the same thing? I'm ignorant to the concept really. Thanks.
Ok. I'll bite. I've been using Opera as an alternative to IE for two years now (in conjunction with Ad-Aware, Spybot, and AVG). For a few websites, I still had to use IE last year but it seems that Opera has become supported enough that with the updates, I don't hardly ever need to use another browser. I can't say that I've investigated Firefox much at all. Where does Firefox rank security-wise with your Operas and other alternative browsers?
What's the prevalence of yersinia pestis these days? Is its acquiring relegated to the same likelihood as anthrax and rabbit fever?
How many other bacteria affect humans in similar methods where inhalation is deadlier than skin contact? Just curious if the same premise of narrowing down why one exposure is less lethal than another could be applied to other bacteria.