You're right about what you're talking about (stabilization of transition state etc.). What I meant is that they don't just start catalyzing a new (type of) reaction - if there are entirely different substrates the cell will just adapt to this with a different set of enzymes - the existing enzymes wont automagically "shape-shift to suit the task at hand" to quote the original article.
Or they could have purchased a few licenses of $PREFERRED_MSOFFICE_VERSION and just keep using that every year. I doubt they would need latest and greatest.
As far as I can tell there are some factual errors - either because the reporter got it wrong or the researches are well.. just chemists and not biologists;)
Natural catalysts, such as enzymes in the human body that help us digest food, get around this problem by shape-shifting to suit the task at hand.
(...)
Natural catalysts reconfigure themselves over and over again in response to different chemical cues -- as enzymes do in the body, for example.
Actually enzymes do a have a somewhat *fixed* fold for a specific (type of) reaction and don't just catalyse this then that etc. They can be highly selective for only one substance / functional chemical group or not. However they certainly don't reconfigure themselves (we're not talking about allosteric enzymes). The cell just produces a different set of enzymes to adjust to new conditions.
In tests, the chemists caused the catalysts to twist one way or the other, either to form one chemical product or its mirror image.
They better have this working 'error-free'. Having a mixture of both shapes can get you into big trouble (http://en.wikipedia.org/wiki/Thalidomide).
"For many chemical reactions to work, molecules must be able to fit a catalyst like a hand fits a glove," RajanBabu said. "Our synthetic molecules are special because they're flexible. It doesn't matter if the hand is a small hand or a big hand, the 'glove' will change its shape to fit it, as long as there is even a slight chemical preference for one of the hands. The 'flexible glove' will find a way to make a better fit, and so it will assist in specifically making one of the mirror image forms."
I'm not sure this is so good - wouldn't you want them to behave like enzymes aswell, being highly selective?
And last but not least there is no comparison offered to *real* enzymes in terms of 'speed' and what kind of reactions besides fatty acid hydrogenation are possible.
And they state that more will come after gathering feedback between then and June.
Between now and June it will garner feedback from the developer community. Then, at the end of June, Microsoft will publish the final versions of technical documentation - along with definitive patent licensing terms.
3G was never planned for this version and even subsequent versions only may get it thy can get buy it in low volume and can write/publish it with GPL'ed driver (if necessary for 3G module). Same goes for a lot of other things that your run-of-the-mill phone boasts. Most chip-makers wont even talk to you if you want low volume + open specs/drivers.
WIFI wouldn't have been included if they didn't find an appropriate chip (for mobile phones) with open drivers etc. or at least the possibility to write an open driver with NDA'ed docs.
it boasts a 500MHz processor, WiFi, 3D accelerometers, a 4.3-inch VGA touchscreen, Bluetooth, and built-in GPS." But will run @ 400 MHz.
2.8 inch VGA touchscreen.
Indeed, protein structures generally need to be solved at a resolution of 8 angstroms or less to be taken seriously. More like 2-4A. 8 Angstroms isn't much either and at 22A you may as well try single-particle EM. They have similar or slightly better resolution and don't depend on diffracting crystals.
Not to dismiss their work, in fact this may be very helpful for all these huge complexes where you're not even close to get nicely diffracting crystals.
which laptops normally can get 5 hours of use from a battery? HP/Compaq Evo n620c with two batteries (one in multibay), Intel Pentium M - 1.5 GHz, lasts around 7-8 hours. YES!
Why (except for size) get those Atom-thingies if something from 2003/2004 can do the same with pretty much same (or more?) speed, 14" screen and normal laptop keyboard. I find it ridiculous that CPU power usage or battery technology has only improved *that much* over the last years.
If you cant remove it by filtering contaminated solutions / equipment then you do the 'other' thing - that is, just cook it up at high temperature and pressure. In addition to that we will just have to build filters with even smaller cut off.
The OLPC project hasn't just jumped the shark. They went out and found a new shark - with friggin' lasers mounted on it - and they are jumping over it now.
Fixed.
It's really just that FUD.
Go to http://www.microsoft.com/
On the upper right is a search field, search for "FUD" - the first or second hit should help you out;)
The very reason I will never buy anything from Steam. If MS (with their huge pockets) can screw their paying customers then I see no reason why Valve couldn't.
I use OpenWetWare primarily to get protocols for experiments. It is quite handy as there are usually several protocols for doing the same thing or comments of how some people do step X or Y different. You can get a much faster overview of a method than the usual learn X only.. then much later you learn about Y and how it could have been a better way to do it.
Slashdot Mirror
Dear All, Sorry for delay long time!!! So far, only GSM850 Freerunner is available in stock, Debug board and spare also!!!
http://lists.openmoko.org/pipermail/community/2008-July/020394.html
The GSM 900 version supports GSM 1800.
You're right about what you're talking about (stabilization of transition state etc.).
What I meant is that they don't just start catalyzing a new (type of) reaction - if there are entirely different substrates the cell will just adapt to this with a different set of enzymes - the existing enzymes wont automagically "shape-shift to suit the task at hand" to quote the original article.
Or they could have purchased a few licenses of $PREFERRED_MSOFFICE_VERSION and just keep using that every year. I doubt they would need latest and greatest.
Natural catalysts, such as enzymes in the human body that help us digest food, get around this problem by shape-shifting to suit the task at hand. (...)
Natural catalysts reconfigure themselves over and over again in response to different chemical cues -- as enzymes do in the body, for example.
Actually enzymes do a have a somewhat *fixed* fold for a specific (type of) reaction and don't just catalyse this then that etc. They can be highly selective for only one substance / functional chemical group or not. However they certainly don't reconfigure themselves (we're not talking about allosteric enzymes). The cell just produces a different set of enzymes to adjust to new conditions.
In tests, the chemists caused the catalysts to twist one way or the other, either to form one chemical product or its mirror image.
They better have this working 'error-free'. Having a mixture of both shapes can get you into big trouble (http://en.wikipedia.org/wiki/Thalidomide).
"For many chemical reactions to work, molecules must be able to fit a catalyst like a hand fits a glove," RajanBabu said. "Our synthetic molecules are special because they're flexible. It doesn't matter if the hand is a small hand or a big hand, the 'glove' will change its shape to fit it, as long as there is even a slight chemical preference for one of the hands. The 'flexible glove' will find a way to make a better fit, and so it will assist in specifically making one of the mirror image forms."
I'm not sure this is so good - wouldn't you want them to behave like enzymes aswell, being highly selective? And last but not least there is no comparison offered to *real* enzymes in terms of 'speed' and what kind of reactions besides fatty acid hydrogenation are possible.
Microsoft releases api/ protocol specs | Feb. 2008
http://www.theregister.co.uk/2008/02/21/microsoft_goes_open/
Microsoft releases further specs | April. 2008
http://www.theregister.co.uk/2008/04/08/microsoft_posts_protocol_documents/
And they state that more will come after gathering feedback between then and June.
Between now and June it will garner feedback from the developer community. Then, at the end of June, Microsoft will publish the final versions of technical documentation - along with definitive patent licensing terms.
3G was never planned for this version and even subsequent versions only may get it thy can get buy it in low volume and can write/publish it with GPL'ed driver (if necessary for 3G module). Same goes for a lot of other things that your run-of-the-mill phone boasts. Most chip-makers wont even talk to you if you want low volume + open specs/drivers.
WIFI wouldn't have been included if they didn't find an appropriate chip (for mobile phones) with open drivers etc. or at least the possibility to write an open driver with NDA'ed docs.
It is not a french phone - where did you get this?
but also dreaming that having to tinker with underlying code base will in the future not be needed anymore [1] and hence increase their share in the HPC market. Even if true - why pay loads of money if you can use Linux for free? [1] http://port25.technet.com/archive/2008/06/18/is-high-performance-computing-naturally-open-source-ie-for-tinkerers.aspx
Yeah because in case of F/OSS they just couldn't download the latest version of $APP via SVN/CVS/GIT/whatever if they wanted to.
Seamonkey uses the same rendering engine doesn't it? I've never had a single problem with Seamonkey / GMail.
Not to dismiss their work, in fact this may be very helpful for all these huge complexes where you're not even close to get nicely diffracting crystals.
Nahhh not at all - with new talent like Majestic Studios, the UK is making a full swing attack at all the cheap-ass clones made by EA-Borg collective.
I even submitted the story about Venezuela (which was rejected) - yet the summary gets it wronger than one can imagine..
Denmark?!
South Arica?!
Why (except for size) get those Atom-thingies if something from 2003/2004 can do the same with pretty much same (or more?) speed, 14" screen and normal laptop keyboard. I find it ridiculous that CPU power usage or battery technology has only improved *that much* over the last years.
If you cant remove it by filtering contaminated solutions / equipment then you do the 'other' thing - that is, just cook it up at high temperature and pressure. In addition to that we will just have to build filters with even smaller cut off.
Err.. EnableBalloonTips=0 anyone?
That must have been in 1999.. as UT wasn't released in 1998 ;)
They also state repeatedly that they would release an update to rid the game of the DRM if the servers or EA/Bioware ever go down.
It's really just that FUD. Go to http://www.microsoft.com/ On the upper right is a search field, search for "FUD" - the first or second hit should help you out ;)
The very reason I will never buy anything from Steam. If MS (with their huge pockets) can screw their paying customers then I see no reason why Valve couldn't.
I use OpenWetWare primarily to get protocols for experiments. It is quite handy as there are usually several protocols for doing the same thing or comments of how some people do step X or Y different. You can get a much faster overview of a method than the usual learn X only.. then much later you learn about Y and how it could have been a better way to do it.
Whenever someone mentions of them, all I remember is this funny article from El Reg: http://www.theregister.co.uk/2006/02/17/itanic_oracle_idc/