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Longevity Gene Found

quixote9 writes "Calorie restriction while maintaining nutrient levels has long been known to dramatically increase life spans. Very different lab animals, from worms to mice, live up to 50% longer (or even more) on the restricted diets. However, so far, nobody has been able to figure out how this works. Scientists at the Salk Institute have found a specific gene in worms (there's a very similar one in people) that is directly involved in the longevity effect. That opens up the interesting possibility that doctors may someday be able to activate that gene directly and we can live long and prosper . . . without giving up chocolate."

358 comments

  1. People demand it by ch-chuck · · Score: 5, Funny

    Give me immortality, or give me death!

    --
    try { do() || do_not(); } catch (JediException err) { yoda(err); }
    1. Re:People demand it by MaXMC · · Score: 1

      There can be only one!

    2. Re:People demand it by beckerist · · Score: 1

      Hey, don't take this life so seriously. It's not like you're getting out alive!

    3. Re:People demand it by RagnarokGod · · Score: 0, Offtopic

      Death by Chocolate ? I've heard that somewhere before ...
      Hex 09 F9 11 02 9D 74 E3 5B D8 41 56 C5 63 56 88 C0

    4. Re:People demand it by homey+of+my+owney · · Score: 1

      | . . . without giving up chocolate. And donuts? Mmmm...

    5. Re:People demand it by Mister+Whirly · · Score: 2, Funny

      I would love to be immortal, but only for a while...

      --
      "But this one goes to 11!"
    6. Re:People demand it by TheLink · · Score: 1

      Being immortal AND NOT invincible - still vulnerable to pain etc ala Highlander could be a bad thing.

      Imagine if you were trapped in a landslide, and you didn't die. You had to spend the next few weeks or even months digging yourself out whilst suffering hunger, pain, thirst etc.

      Or worse, some sadistic psycho captures you and finds out that you can't die...

      So if you ever had a chance at immortality you better read the fine print and think very carefully.

      --
    7. Re:People demand it by jcgf · · Score: 1

      I'd still take Highlander style immortality. The scenarios you point out could be easily avoided.

    8. Re:People demand it by Jorgandar · · Score: 1

      Oww! Dont say funny stuff while my mouth is full of coffee!

    9. Re:People demand it by Aliriza · · Score: 1

      Give me immortality, give me chocolate and happiness.

    10. Re:People demand it by Gilmoure · · Score: 1

      He might strap you to a rock and let an eagle eat your vulture each day.

      --
      I drank what? -- Socrates
    11. Re:People demand it by Gilmoure · · Score: 1

      D'oh! Replace vulture with liver.

      Man, I need a beer.

      --
      I drank what? -- Socrates
    12. Re:People demand it by LouisZepher · · Score: 1

      Not really. I recall an episode of the television series wherein at one point in his past, Duncan was a ship's mate under an unreasonable (and immortal) captain. The crew mutinied and wanted to behead said captain, but Duncan convinced them to simply strand the captain on a deserted island so he'd at least have a chance to survive. Turns out that what little water and vegetation there was on the island was unfit for consumption, and the immortal captain essentially died of thirst every couple days, then revived and died all over again...for something like 80 years. When the two met in modern times, the now very-understandably crazy former captain tried to trap Duncan in a basement prison with no food or water only to be let out after a similar length of time.

      I also recall another episode that featured Nefertiti. In her case, she would revive in her coffin only to suffocate minutes later. By modern times, she was quite bat-shit insane.

    13. Re:People demand it by RockModeNick · · Score: 1

      Only that never made sense, because they don't drown, they can just walk around underwater if weighted.

    14. Re:People demand it by lessthan · · Score: 1

      I thought you were trying to imply something crude. I was all, "Vulture why would he call it his vulture?"

      --
      Space Shuttle was a program that strapped humans to an explosion and tried to stab through the sky with fire and math
    15. Re:People demand it by Gilmoure · · Score: 1

      I was trying to remember whether the legend said eagle or vulture. Finally, because it was Zeus doing this to Prometheus, I decided on eagle. Brain, of course, had vulture on the mind and out it came.

      --
      I drank what? -- Socrates
    16. Re:People demand it by LouisZepher · · Score: 1

      Much about the series didn't make sense. Hell, I think that everything after the first movie was just a series of weird-ass dreams Connor was having during the last quickening. Gah, don't even get me started on the Connor vs Duncan outcome in the last movie. Fucking Quintin could kick Duncan's ass...

    17. Re:People demand it by Ed_Pinkley · · Score: 1

      This is one of the differences between the movies (without Duncan) and the tv show / movie with Duncan. Here is the wikipedia entry. It is pretty spotty. There used to be a nice faq in alt.tv.highlander but I can't seem to find it. Seems like that would be a nice thing to put in wikipedia. (If someone still has it. I'm jus sayin')

      --
      "Long time listener, first time caller."
    18. Re:People demand it by Chacham · · Score: 1

      magine if you were trapped in a landslide, and you didn't die.

      IIRC, in Lode Runner ctrl-a was instadeath just for such situations/

  2. OTOH by Virtual_Raider · · Score: 4, Insightful

    I am of two minds on this. I'd like to enjoy a longer lifespan than I would otherwise expect and I would want my loved ones (and everyone in the world for that matter) to have it too. But if according to the wikipedia we are well over SIX THOUSAND MILLION people alive at the moment, the world would find itself in a much worse position if we stopped dieing and clearing the way for younger generations.

    --
    +Raider of the lost BBS
    1. Re:OTOH by $RANDOMLUSER · · Score: 4, Insightful

      Don't worry about it. Market forces will make it such that only the richest 3% of the population can afford the treatment.

      --
      No folly is more costly than the folly of intolerant idealism. - Winston Churchill
    2. Re:OTOH by pipatron · · Score: 4, Insightful

      Please check http://www.vhemt.org/ for a better solution than dying.

      --
      c++; /* this makes c bigger but returns the old value */
    3. Re:OTOH by vidarh · · Score: 5, Insightful
      Birth rates are already well below maintenance levels in most industrialized countries, and even China is set to see it's population peak soon due to the one child policy. The solution to the problem of too high growth is helping developing countries out of poverty.

      We're maybe as little as a century away from actually seeing the worlds population shrinking unless we start increasing lifespans a lot faster than we have.

    4. Re:OTOH by dsanfte · · Score: 2, Interesting

      As long as there are gene sequencer machines on the market and people like me studying cell biology, don't worry, it'll be done in private residences. Switching on genes isn't so hard.

      --
      occultae nullus est respectus musicae - originally a Greek proverb
    5. Re:OTOH by Anonymous Coward · · Score: 0

      What is "Mainainence level"? Maintaining social security? Or maintaining rate of growth?

    6. Re:OTOH by teslar · · Score: 4, Insightful

      (...) the world would find itself in a much worse position if we stopped dieing and clearing the way for younger generations.
      Well, that's the thing, we won't stop dying - we'll only stop dying of old age. There's still plenty of accidents and murders to keep the population under control. Also, I'm pretty sure that if you could actually have eternal life, you'll get bored of it eventually and will top yourself given that nature's no longer doing the job for you. And I'll bet that would happen before your 200th birthday.

      I'd like to enjoy a longer lifespan than I would otherwise expect
      I guess not all long lives are the same - having the body of a 20 year old for 100 years instead of, well, one is one thing, having the body of a 150 year old who would normally have died 80 years ago for 100 years is quite another. So be careful what you wish for when you ask for longer lifespans. Make sure you read the fine print first :)
    7. Re:OTOH by Virtual_Raider · · Score: 2, Insightful

      Wow, my first "flamebait" :P Totally undeserved if we judge by the responses I got, which by the way were exactly the kind of discussion I wanted to have. Oh well, enough whining. I know that population rates decline on industrialized countries, but they don't hold the bulk of the population anyway. China alone has over a billion people, yes, but India has another and they have no such policy. And neither do many of the developing countries. So unfortunately it just seems like the weight of the population is just going to shift even more towards the places where living standards aren't the greatest, which will make all the more difficult for them to improve their quality of life.

      --
      +Raider of the lost BBS
    8. Re:OTOH by teslar · · Score: 1

      There's still plenty of accidents and murders to keep the population under control.
      And illnesses, sicknesses and the like. Forgot them, sorry - but they are important.
    9. Re:OTOH by Knutsi · · Score: 1

      If "we" help the poor countries out of poverty and into a society like those of the industrialized nations where birth-rates pr. person are negative, would there still be food and raw materials on this planet left to run a society like that?

    10. Re:OTOH by fredrated · · Score: 1

      I think the point the poster is making is that if we increase life span by say 50% then we are effectively increasing the population (in the long run) by 50%. Three people that live to 80 are the equivalent to 2 people that live to 120, 3 people soon to be living to 120 is a 50% increase in the population.

    11. Re:OTOH by khallow · · Score: 1

      I guess it would be something of an effort to figure out. But is the lives of 6 billion people worth the effort to figure this problem out? Of course.

    12. Re:OTOH by khallow · · Score: 4, Insightful

      Also, I'm pretty sure that if you could actually have eternal life, you'll get bored of it eventually and will top yourself given that nature's no longer doing the job for you. And I'll bet that would happen before your 200th birthday.

      Either that, or after 200 years, they'll have figured out how to not be bored. Frankly, it's not that hard.
    13. Re:OTOH by lixee · · Score: 1

      I concur. Thomas Friedman was quoted as saying: "Capitalism eradicates poverty not mortality".

      --
      Res publica non dominetur
    14. Re:OTOH by Anonymous Coward · · Score: 0

      Don't worry, there's probably a downside to this gene, otherwise evolution would have likely made it common place.

      My guess is either:
      * sterility (if you're starving, there's little point in reproducing)
      * cancer or vulnerability to disease

    15. Re:OTOH by Anonymous Coward · · Score: 0

      FEOY (for every one's information), the increase in population is not related to increase in birth rate, but decrease in death rate. It is a common myth that people are giving birth to too many children. It is the decrease in death rate that China's population is still increasing even though their birth rate has decreased from a long time. (It will decrease in time, when it will look like Europe - too many old people and not many children)

      And yes, even then the solution is helping developing countries out of poverty.

    16. Re:OTOH by tomhudson · · Score: 0, Troll

      "I know that population rates decline on industrialized countries"

      You want a real flame - try the truth, like this:

      The US is going to be among the worst offenders in contributing to over-population over the next 40 years: http://en.wikipedia.org/wiki/Overpopulation

      During 2005-2050, nine countries are expected to account for half of the world's projected population increase: India, Pakistan, Nigeria, Democratic Republic of the Congo, Bangladesh, Uganda, United States of America, Ethiopia, and China, listed according to the size of their contribution to population growth.

      China, with 4 times the population, will grow less than the US.

      Now keep in mind the US's environmental footprint (5% of the worlds' population, 26% of all energy consumption) - so as the US population more than doubles to 650 million, you're looking at some serious shortages.

      Of course, there's always this "inconvenient truth" http://www.worldwatch.org/node/810

      An estimated 65 % of U.S. adults are overweight or obese, leading to an annual loss of 300,000 lives and at least $117 billion in health care costs in 1999.

      In 2002, 61 % of U.S. credit card users carried a monthly balance, averaging $12,000 at 16 % interest. This amounts to about $1,900 a year in finance charges--more than the average per capita income in at least 35 countries (in purchasing power parity).

      A nation drowning in debt at all levels, addicted to junk food, junk credit, and junk science for its environmental "policies".

      Its the truth, and its also flamebait :-)

    17. Re:OTOH by syntaxglitch · · Score: 4, Informative

      What is "Mainainence level"? Maintaining social security? Or maintaining rate of growth?

      Maintaining raw population, meaning a growth rate greater than or equal to zero. Many first-world nations (notably, Japan and much of Europe) have more people dying than being born, resulting in negative population growth.

      In general, education level and availability of technology correlate negatively with birth rate, and this holds true both between countries and between socio-economic groups within countries.

    18. Re:OTOH by tomhudson · · Score: 1

      "Three people that live to 80 are the equivalent to 2 people that live to 120,"

      So in theory, if I bump off 20 60-year-olds, I should live past 1,000 ... oh well, that's ONE way to save Social Security, but it sounds like voodoo math to me ...

    19. Re:OTOH by Virtual_Raider · · Score: 1, Flamebait

      And another problem with that is that We The People like the way we live, whatever it may be, because that's the way we live. We grow attached to our culture and the longer we spend inside it, the harder it is for the majority to view it with a critical eye and weed out its issues. Then throw more people that learn and inherit that culture in the mix, and I think that nothing short of one of those fabled "inflection points" will modify it.

      --
      +Raider of the lost BBS
    20. Re:OTOH by Verunks · · Score: 1

      oh my god bill gates immortal?

    21. Re:OTOH by montyzooooma · · Score: 1

      I can't remember when or where I read it but I'm pretty sure I read a SF story in which people with incredibly long lifespans would just regularly get their memories blanked so they could re-invent themselves.

    22. Re:OTOH by Anonymous Coward · · Score: 0

      I, for one, with a heavy heart, welcome our new, condolent, undertaking robotic overlords...

    23. Re:OTOH by pakar · · Score: 2, Interesting

      Well, i think living longer would be good, if some limitations on offspring would be created, something like that each parent is allowed to have 1 child. = a couple can have 2 children.

      Pros:
      - Less money spent on education since the productive years of each person would be much longer, just think of what the pay would be for a *nix admin with 120 years of experience that still have 80 years left until retirement :)
      - Less money spent on caring for the elderly, since people would probably choose to end their life sooner since not everyone would want to be 300 years.
      - More time to save money for when you get old.
      - Less need for healthcare since people are 'younger' longer.
      - You could spend 30 years in school if you really wanted, or maybe go back to school once every 40 years if you are bored with your current line of work.
      - When you choose to get children you could have saved up enough money to stay at home with them until they move out, if you want.
      - Less rush on life.

      Cons:
      - A life-sentence would really be something then =)
      - Just hope that you only get 'old' just before you die.
      - Hope for a creative job. Don't even want to imagine a 100 years as a garbage-collector (or sanitation-worker if you want to be politically correct :)
      - I would guess it would result in a lot more divorces.. 200 years with the same girl... 200 years of shopping... GAAAH where's that poison-needle? =)

      So i think that this would be a good thing for almost everyone.

    24. Re:OTOH by smchris · · Score: 1

      I am of two minds on this. I'd like to enjoy a longer lifespan than I would otherwise expect and I would want my loved ones (and everyone in the world for that matter) to have it too.

      Skip the latter thought. That's why there are vampire novels.

      Actually, I'm deadly serious. The reason Frankenstein made it into the diversity of the English literature canon is because it mythologized doubt about the rise of science at the end of the 19th century, right? I suggest it is possible the future canon may teach Anne Rice's Interview with the Vampire. Those who can suck enough liquid money unto themselves can already extend their lives decades beyond the poor of the world. We may be on the cusp of a time where the rich will need a morality rationalizing an abnormal lifespan only they can afford to maintain.

    25. Re:OTOH by Red+Flayer · · Score: 1

      I am of two minds on this.
      Well, since the study said it's about earthworms, I'll say that I'm of five pairs of hearts about it.

      Seriously, though, if the average person loved and extra 35 years, the drain on the world's resources would be HUGE. And economically, we'd all have to work much, much longer in order to support our retirements, and the gap between rich and poor would increase. I'm not sure I'd be enthused with working for 90 years before retirement, and I don't know what widening the income gap further would do.
      --
      "Trolls they were, but filled with the evil will of their master: a fell race..." -- J.R.R. Tolkien on Olog-hai
    26. Re:OTOH by pakar · · Score: 1

      Well, downside for us or the propagation of the species?

      If you live longer you have a bigger chance of getting cancer or some illness that was incurable so by forcing us to have children early in life between the age of 15-30(?) was probably the best way to keep our genes alive.
      But today with our advances in medicine i think this has changed into something of a downside since we require quite a bit of education before someone can get a good job and provide for their families. So today i think it would be better for the genes survival to have an span between 25-40 years instead.

      ---- Everything is evolving and now we are learning how to control our own evolution, for better or worse.

    27. Re:OTOH by kalirion · · Score: 1

      Hahaha, now there's an example of Darwinism in action!

      Personally, I never plan on having children myself, but it's for completely selfish reasons, and if I find an acceptable means to prolong my life, whether it's genetics or cybernetics or whatnot, you can bet I'm gonna take it.

    28. Re:OTOH by Intron · · Score: 1

      I don't think you've thought this through. Children are your only path to immortality.

      What good is long life unless all of the diseases of old age are cured? Prostate cancer, alzheimer's, osteoporosis - none of those are much fun.

      --
      Intron: the portion of DNA which expresses nothing useful.
    29. Re:OTOH by Intron · · Score: 1

      Natural selection doesn't favor traits that help you live much past child-bearing age. Once the cubs are on their own, you are useless to evolution.

      --
      Intron: the portion of DNA which expresses nothing useful.
    30. Re:OTOH by lordSaurontheGreat · · Score: 1

      You mean 0.03% - Most of the richest 3% don't have access to the experimental healthcare required.

      --
      Consider yourself spoken to.
    31. Re:OTOH by Anonymous Coward · · Score: 0

      Better yet, stop reproducing too.

    32. Re:OTOH by Bobb+Sledd · · Score: 1

      Are you suggesting that we are over-populated? Sure, in some places but not others. There are cities where people fight for breathing room, I know. But have you ever been to North Texas or West Texas? There's no one there! Wide open space, with infrastructure to boot! And most of Australia is just wilderness, just waiting to be tamed and civilized. There are so many remote places for people to live without being cramped and crowded it's hard for me to believe that we're over-populated globally.

      Besides, I doubt that anyone who could afford this technology (meaning not 3rd world countries, that is) would make much of a difference in world population growth either way.

      So what is the problem?

      --
      "They said I probly shouldn't fly with just one eye," "I am Bender. Please insert girder."
    33. Re:OTOH by mangu · · Score: 1
      a SF story in which people with incredibly long lifespans would just regularly get their memories blanked so they could re-invent themselves


      The way people have reinvented themselves up to now is by having children. Do you think having your memory blanked would be funnier than making children? No, this one definitely doesn't seem to be an improvement over the current situation.

    34. Re:OTOH by Anonymous Coward · · Score: 0
      The US is going to be among the worst offenders in contributing to over-population over the next 40 years:

      You left out this part:

      During 2005-2050, the net number of international migrants to more developed regions is projected to be 98 million. Because deaths are projected to exceed births in the more developed regions by 73 million during 2005-2050, population growth in those regions will largely be due to international migration.

    35. Re:OTOH by kalirion · · Score: 2, Insightful

      Some pirates achieved immortality by great deeds of cruelty or derring-do. Some achieved immortality by amassing great wealth. But the captain had long ago decided that he would, on the whole, prefer to achieve immortality by not dying. - Terry Pratchett, The Color of Magic

      As nice as it would be to leave some sort of a lasting legacy behind, I would greatly prefer to be there myself. Even if Prestige-like technology existed to make an identical clone, memories and all, it would not be enough. Obviously if living becomes too much of a burden, there's always suicide. Anyway, I have a feeling we'll have a cure for alzheimer's long before we have a cure for aging.

    36. Re:OTOH by Intron · · Score: 1

      You won't be there "yourself" in any case. Are you the same person that existed 20 years ago with the same name? I know that I am very different. You might even think you are the same person, but that's just a trick of biology.

      --
      Intron: the portion of DNA which expresses nothing useful.
    37. Re:OTOH by kalirion · · Score: 1

      Would you consider taking a 100% fatal slow acting poison that has no antidote and takes 20 years to kill to be murder instead of suicide? The point is I have a definition for 'myself', and it doesn't include clones or children.

    38. Re:OTOH by gstoddart · · Score: 1

      As long as there are gene sequencer machines on the market and people like me studying cell biology, don't worry, it'll be done in private residences.

      Why am I envisioning shady, backroom genetic re-sequencing a la scene in Minority Report where Tom Cruise gets his eyeballs removed so he can pass retinal scanners? That just sounds scary.

      Switching on genes isn't so hard.

      Wow, have we come so far we can say that with a straight face? I don't think we're ready for the counter-top "Mister Gene-Therapy" just yet. I sure as heck didn't think it had become easy or routine.

      This really doesn't strike me as something that we'd like to see happening in a willy-nilly manner. (Unless someone can give me super powers, then I'm all for it. =)

      Cheers
      --
      Lost at C:>. Found at C.
    39. Re:OTOH by umbra_dweller · · Score: 1

      I think U.S. growth rates are mainly due to immigrants, though.

    40. Re:OTOH by ShadowsHawk · · Score: 1

      So the US's poor are also likely to be over weight. It's a terrible situation that the poor can afford an abundance of food. Granted, this 'food' may not be nutritionally sound and they may make poor financial choices, but is it really an issue? Most people know that MC Donalds is not health food and I'd wager that just about everyone knows that you have to pay back a credit company when you charge something. It's a matter of personal responsibility.

    41. Re:OTOH by Anonymous Coward · · Score: 0

      I take it you live in a big city. Most of America is dead empty, and it's a damn big country. BTW, "dieing"? It's time to move to Firefox, dear. You need that spelling checker. BTW, "six thousand million" is what we like to call "six billion". You're welcome.

    42. Re:OTOH by Intron · · Score: 1

      Ask any smoker. People trade off risk to their future self for current pleasure all the time. The future self is "less real" then the current self, and people are much more willing to endanger that other person.

      --
      Intron: the portion of DNA which expresses nothing useful.
    43. Re:OTOH by mcrbids · · Score: 1

      Don't worry about it. Market forces will make it such that only the richest 3% of the population can afford the treatment.

      Really? You think that many? I just might have a chance, then... See 3% is a very large number. It's practically mainstream. 3% of people means that you likely know 4-5 of them fairly well, enough to know where they live and the name of their dog.

      --
      I have no problem with your religion until you decide it's reason to deprive others of the truth.
    44. Re:OTOH by Scrameustache · · Score: 1

      As long as there are gene sequencer machines on the market and people like me studying cell biology, don't worry, it'll be done in private residences. Switching on genes isn't so hard. That actually got me to START worrying! Thanks a lot, Dr. Frankenstein.
      --

      You can't take the sky from me...

    45. Re:OTOH by rask22 · · Score: 1

      Maybe if our best and brightest didn't die every 75 years we would have some people living off world by now..

      Ah well, wishful thinking.

    46. Re:OTOH by xtal · · Score: 1


      But if according to the wikipedia we are well over SIX THOUSAND MILLION people alive at the moment, the world would find itself in a much worse position if we stopped dieing and clearing the way for younger generations


      The cheap oil and energy will be largely done in 8-12 years. I wouldn't worry about it.

      --
      ..don't panic
    47. Re:OTOH by Abcd1234 · · Score: 1

      The way people have reinvented themselves up to now is by having children.

      Oh, so *that's* how you reinvent yourself. See, I just figured that was an easy way to sacrifice your own needs and wants for 18-20 years, after which you get to try and make up for all the time you spent dedicated to your kids.

      Yeah... I think I'll take the memory wipe, thanks.

    48. Re:OTOH by samantha · · Score: 1

      The quote is right. Only intolerant idealism would rain on possible great longevity improvements because they may at first be too costly for the majority.

    49. Re:OTOH by kalirion · · Score: 1

      So would the smokers admit to committing murder? And should contributing to a 401k account be thought of a charity?

    50. Re:OTOH by tomhudson · · Score: 1

      People aren't being told that the calories they're taking in are worse than "empty". Sugar from sugar cane and beets are dissacharides - fructose is a monosaccharide. Dissacharides don't depress insulin and leptin levels - they increase insulin levels. Eat cane or beet sugar, and you body will "register" that you've taken in calories. Eat fructose, and it switches off (by depressing leptin levels) your ability to notice that you've eaten allthose calories - you still feel hungry.

      So, we have a food industry that markets the equivalent of crack - the more you eat, the more your body says you have to eat - because it makes yor body tell your brain "I'm hungry."

      A ban on fructose in favour of dissaccharides would drop obesity and overweight levels by more than half - rich OR poor.

    51. Re:OTOH by evilviper · · Score: 1

      according to the wikipedia we are well over SIX THOUSAND MILLION people alive at the moment,

      Really? Because I'd imagine Wikipedia would say that there are 6 billion people, instead of making up numbers...

      Does Wikipedia also mention that population is actually declining in the Western world, as well as some parts of the East like China and Japan? Because that fact would be an incredibly relevant point in this discussion...
      --
      Slashdot gets worse every day... Pipedot: News for nerds, without the corporate slant
    52. Re:OTOH by Ashish+Kulkarni · · Score: 1

      Thank you for the very interesting link!

    53. Re:OTOH by rozz · · Score: 2, Insightful

      As long as there are gene sequencer machines on the market and people like me studying cell biology, don't worry, it'll be done in private residences. Switching on genes isn't so hard.

      thx for the good news.
      and good luck!

      and for the shitless scared luddites that hear about some tech advance and start talking about frankenstein and whatnot .. pls go join the first amish community or whatever ... there you will be able to share your fear with same minded ppl and be "happy".

      humans are supposed to advance ... we may conquer the space and time, or we may destroy ourselves ... noone knows for sure and nothing says that humans must live forever .. but stagnation (at any level) is a sure path to extinction

      --
      "There is nothing more frightful than ignorance in action." Johann Wolfgang von Goethe
    54. Re:OTOH by rozz · · Score: 1

      Would you consider taking a 100% fatal slow acting poison that has no antidote and takes 20 years to kill to be murder instead of suicide? The point is I have a definition for 'myself', and it doesn't include clones or children.

      that a lovely answer ... quite some logic skills there, congrats.

      but i do not understand your "no children" selfishness ... maybe you should check a movie called Idiocracy and see what happens when high-IQ people decide not to have children.
      there may come a point in the future when humans can safely stop having children .. but that is definitely not now .. and prolly not soon.

      --
      "There is nothing more frightful than ignorance in action." Johann Wolfgang von Goethe
    55. Re:OTOH by rozz · · Score: 1

      Its the truth, and its also flamebait :-)

      well, looks like the /. moderators think you are wrong ... Truth is in fact Troll :-)

      anyway .. congrats for a well documented post

      --
      "There is nothing more frightful than ignorance in action." Johann Wolfgang von Goethe
    56. Re:OTOH by pubwvj · · Score: 1

      "you'll get bored of it eventually and will top yourself given that nature's no longer doing the job for you. And I'll bet that would happen before your 200th birthday." What a sad life you must have to be so bored. I'm never bored. There is so much to do. So much to learn. So much to create. If you're really bored then change. Or I suppose if you prefer you could just "top yourself" and help keep the population down. This leads to an interesting corollary: the more creative, non-bored people will live longer and eventually make up more of the population. How wonderful! This will make life richer and more rewarding for them and the people to come. It's a vicious cycle upward!

  3. Retirement age.. by rf0 · · Score: 4, Funny

    If we do live longer to say 150 and you retire at say 70 would you really want to spend 80 years doing nothing..

    1. Re:Retirement age.. by maxwell+demon · · Score: 3, Insightful

      Why would you do nothing after you retire?

      --
      The Tao of math: The numbers you can count are not the real numbers.
    2. Re:Retirement age.. by Scarblac · · Score: 2, Insightful

      There's no way society would be able to afford that. If we all lived to 150, you'd see the retirement age raised to 100+.

      That said, being retired doesn't mean you do nothing...

      --
      I believe posters are recognized by their sig. So I made one.
    3. Re:Retirement age.. by yoprst · · Score: 1

      yes, indeed

    4. Re:Retirement age.. by MadCow42 · · Score: 4, Insightful

      Well, "retirement age" is just a reflection of what point in your life you become:

      1) able to financially support yourself for the rest of your life without continuing to work, and

      2) possibly no longer valuable in the workforce (i.e. too expensive for the quality/quantity of work you can contribute)

      Living longer would mean you need more money to support yourself in retirement, or that you need to delay retiring. The second point depends on what health state (and mental state) you're in at an older age.

      Personally, I plan to retire as soon as possible - but there's no way I could support myself and wife/etc. for 80+ years on what I've saved to date!

      MadCow.

      --
      I used to have a sig, but I set it free and it never came back.
    5. Re:Retirement age.. by Anonymous Coward · · Score: 0

      The only way to support this if your networth generate more revenue than inflation and your _SPENDING_.

      If I stay single and live the same fugal way that I am right now and work the next 6-7 year in a high paying job, I can do this at age 50.

    6. Re:Retirement age.. by Rik+Sweeney · · Score: 1

      If we do live longer to say 150 and you retire at say 70 would you really want to spend 80 years doing nothing..

      What makes you think your government would allow you to retire at 70 if you lived to 150?

    7. Re:Retirement age.. by Anonymous Coward · · Score: 0

      you mean 80 more years? rhetorical question really.

    8. Re:Retirement age.. by jbarr · · Score: 1

      If we do live longer to say 150 and you retire at say 70 would you really want to spend 80 years doing nothing..
      I'm more worried that things like Social Security, 401(k) redemption, and the like will get bumped up to say, 120 years. Lotsa people investing and paying into systems, the fruits of which they will ultimately never see.
      --
      My mom always said, "Jim, you're 1 in a million." Given the current population, there are 7000 of me. God help us all!
    9. Re:Retirement age.. by mangu · · Score: 1
      Living longer would mean you need more money to support yourself in retirement, or that you need to delay retiring


      Not necessarily. If you reach a point where your investments are enough to sustain you indefinitely, it doesn't matter how long you live after that. Anyway, when you retire it's a very bad decision to start spending as if you knew when you'll die. Better leave the principal growing enough to compensate for inflation and live off the interest alone.

    10. Re:Retirement age.. by Eccles · · Score: 1

      If we do live longer to say 150 and you retire at say 70 would you really want to spend 80 years doing nothing..

      I have a government job. I already do that.

      I keed, I keed!

      --
      Ooh, a sarcasm detector. Oh, that's a real useful invention.
    11. Re:Retirement age.. by mfrank · · Score: 1

      If you make a reasonable attempt to save and invest, by the time you're 70 you won't need the government's "permission" to retire.

      And if they have a problem with it, well, screw 'em. Outsource your retirement. There are towns in Mexico that cater to American retirees. There are retirees living there on 400 bucks a month. Heck, I could easily retire there *now* on what I've got in investments, and I won't be eligible for Social Security for twenty more years.

      Rich people get the laws they want. Rich people are rich primarily because they own equities. If you own equities, you get some of that protection.

    12. Re:Retirement age.. by Kyont · · Score: 1

      > 1) able to financially support yourself for the rest of your life without continuing to work, and
      > 2) possibly no longer valuable in the workforce (i.e. too expensive for the quality/quantity of work you can contribute)

      Shit, by that definition, at least three-quarters of my so-called professional colleagues are already retired..

      --
      You shall see a cow on the roof of a cotton house.
    13. Re:Retirement age.. by evilviper · · Score: 1

      If we all lived to 150, you'd see the retirement age raised to 100+.

      Why? My Grandfather was lower-middle class, working as a low-paid laborer his entire life, and by the time he retired, he had over $200,000 in the bank, and was making more in interest than he and his wife could reasonably spend.

      Middle-class people could retire at 40, and live off their savings forever, if they simply knew how to live within their means.

      It always astonishes me to see a "poor" family buying new cars every 4 years. It astonishes me to see a middle class family move into a mansion of a house, in the most expensive neighborhoods around, and nearly going hungry, going without insurance, etc., etc. to make payments on their giant, empty, house.

      I don't know what happened... People that lived through the 30s tend to go to extreme lengths to avoid spending a small amount of money, and yet their children and grandchildren went to the other extreme, and waste money left-and-right, even when both parents work, they're spending 100% of their income, plus 2% of their savings, each year...
      --
      Slashdot gets worse every day... Pipedot: News for nerds, without the corporate slant
    14. Re:Retirement age.. by chris.evans · · Score: 1

      Or you end up working at mcdonalds for 80years because your retirment fund ran out.

    15. Re:Retirement age.. by Geminii · · Score: 1

      Well, there's a number of possibilities. 1) The retirement age is extended to 120. 2) Lots of over-70 people start up their own businesses hiring people over 70. Eventually, traditional businesses start hiring away some of the whitehairs, and the businesses mix. 3) Given the sheer number of new inventions and activities being invented every day, if you can't think of something interesting to see, do or try you're probably better off dead anyway. 4) As an interesting side effect, with more people in the world, investment return rates and inflation would probably rise as demand for scarce resources increases. "I remember when you could buy that for only HALF that price!" "That was last week, Grampa."

  4. Gene sequence in hex is... by Bob54321 · · Score: 5, Funny

    09 F9 11 02 9D 74 E3 5B D8 41 56 C5 63 56 88 C0

    (That is going to hurt my karma but I am still no bored of that joke...)

    (OK, maybe a little over it)

    --
    :(){ :|:& };:
    1. Re:Gene sequence in hex is... by Anonymous Coward · · Score: 0

      +4 Funny?
      Ouch, your poor karma.

    2. Re:Gene sequence in hex is... by pipatron · · Score: 1

      You know, it would be even funnier if you had changed a digit or two, or swapped some...

      --
      c++; /* this makes c bigger but returns the old value */
    3. Re:Gene sequence in hex is... by fredrated · · Score: 1

      I hope this helps people realize that once a digital secret is out of the bag, it really is out of the bag.

    4. Re:Gene sequence in hex is... by Bob54321 · · Score: 1

      Well, we know there must be two variants of the gene, one for long life and one not. We just need to find some "next-key" HD-DVDs to find the other the variant...

      --
      :(){ :|:& };:
    5. Re:Gene sequence in hex is... by LiquidCoooled · · Score: 0, Offtopic

      I don't see it as out of the bag, I see it as free advertising to HD-DVD and digg

      Think about the blanket coverage this number is getting, you couldn't pay for something like this.
      How many people watching the normal news now know that HD-DVD is the high definition format that just wouldn't have known before?

      The MPAA overlords must be really happy.
      Who has most to gain by us "fighting the man" about this number?

      --
      liqbase :: faster than paper
    6. Re:Gene sequence in hex is... by serialdogma · · Score: 1

      On the risk of going off-topic, no it only shows that as soon as slashdotters are handed a dead donkey they will continue to beat it till long after it is no longer funny nor amusing.

    7. Re:Gene sequence in hex is... by mkcmkc · · Score: 1

      That's not the way I heard it...

      --
      "Not an actor, but he plays one on TV."
  5. Who would want to live forever? by Anonymous Coward · · Score: 0

    Who would want to live more than say, 70 years? You don't want nurses to take you to toilet etc. because you're too old to be able to do that yourself. I say 70 years is enough.

    1. Re:Who would want to live forever? by Anonymous Coward · · Score: 0

      Yep. 70-80 years should be enough for anybody to get tired of life. If they discovered anything to life better (not longer)... that would be something interesting.

    2. Re:Who would want to live forever? by Anonymous Coward · · Score: 0

      You don't want nurses to take you to toilet

      And why, exactly, not??

    3. Re:Who would want to live forever? by bodan · · Score: 1

      Because they might look like that: http://urbainalpain.punt.nl/upload/fat_nurse.jpg

      --
      "I think I am a fallen star. I should wish on myself."
    4. Re:Who would want to live forever? by tomhudson · · Score: 4, Funny

      3 men in an old-age home were comparing notes.

      The 70-year-old said that he needs to go to the toilet first thing in the morning, and it takes him 10 minutes just to get out of bed, and another half-hour in the can, so he has to get up at 6:30 if he's going to make it for breakfast at 7:00

      The 80-year-old said "You think that's bad? It takes me half an hour to get out of bed, and an HOUR in the toilet, so I have to get up at 5:30 in the morning if I'm going to eat breakfast at 7:00. Heck, I have to take half a viagra so I don't end up pissing on my slippers!

      The 90-year-old says "You young'uns ... I wake up at 6:55, have a piss, take a shit, and I'm all done by 7:00 ... then I have breakfast, while they change my sheets."

    5. Re:Who would want to live forever? by ChrisMaple · · Score: 1

      Please think before you post. If a person is too ill to go to the toilet, he is in all likelihood too ill to live long. Except for "heroic" life support, life extension is achieved through lengthening the healthy portion of life, the portion of life that is enjoyed and desired in larger quantities.

      --
      Contribute to civilization: ari.aynrand.org/donate
  6. Good work. Not. by Anonymous Coward · · Score: 0

    The longevity gene would be the one we DON'T need.

  7. Today's society by ilovegeorgebush · · Score: 1

    Give it a year or two and these'll be in pill form, no doubt. Interesting research though.

    1. Re:Today's society by Anonymous Coward · · Score: 1, Funny

      Great. Like we really need the Boomer generation hanging around for another 90 years.

  8. Ponce de León still searching... by Door+in+Cart · · Score: 5, Insightful

    Our current life expectancy is already putting such a burden on our social security system. When will people realize that quality of life != quantity of life? How is our great-grandkids' generation supposed to support millions of supercentenarians?

    1. Re:Ponce de León still searching... by yoprst · · Score: 2, Funny

      Don't worry! Goverments all around the world are already working on this problem. Lower prison terms, sensible immigration policies, and humane international policies are already there. More to come...

    2. Re:Ponce de León still searching... by Bogtha · · Score: 2, Funny

      How is our great-grandkids' generation supposed to support millions of supercentenarians?

      Won't somebody please think of the great-grandchildren!?

      --
      Bogtha Bogtha Bogtha
    3. Re:Ponce de León still searching... by Anonymous Coward · · Score: 1, Insightful

      OH JESUS FUCKING CHRIST, if you have double longevity you dont get infirm at 70 and live like a cabbage for another 90 years. your entire life scales up, so you'd get infirm at 140 and have 20 years as a leech, which aint much more than people have now.

    4. Re:Ponce de León still searching... by Angstroem · · Score: 1

      Our current life expectancy is already putting such a burden on our social security system. When will people realize that quality of life != quantity of life? How is our great-grandkids' generation supposed to support millions of supercentenarians?
      Well, the point here is not to prolongue the life for the sake of staying merely alive, i.e. losing your mind and control over body functions, but instead staying *young*. What good is it to become 250 years old, when the last 180 years of that you spend in the clinic section of a retirement home not knowing what happened 5 minutes ago -- which is a good thing cause you don't remember that you just got new diapers cause you lost control over bladder and sphincter almost two centuries ago.

      I wouldn't mind if my age would be biologically frozen at about 50 (I'm 35 now and I think that 15 years is about as fast as possible in developing such an anti-age cure) where I then have another 50-70 years of staying 50. If they can make it within 5 years, even better. As a 50-year-old becoming 100-120 I wouldn't be a burden on the social security system or medicare, as I will be still able to maintain a job -- or just retire and live self-sufficient after I accumulated enough money.

      With a longer and healthier lifespan maybe the interest of humankind then changes back from the fast buck to things which are profitable to the entire race, like basic research (which might result in a useful product 50 years later), keeping this planet inhabitable, exploring the solar system and space, and spread the human race to some more planets.

    5. Re:Ponce de León still searching... by AGMW · · Score: 2, Insightful
      ... or just retire and live self-sufficient after I accumulated enough money

      If people end up living to 200 or 250 (obviously, whilst retaining their faculties) why would they necessarily "work-then-retire"?

      Why not work until you have enough put by to have 5/10/15 years doing something you like doing, then work a bit more, then have more time off. This way you wouldn't have to work until you are 100 before you could enjoy yourself! Much better to work until you are, say, 30, then have 5 years off, then work some more. Rinse Lather Repeat, er, Profit?

      --
      Eclectic beats from Leeds, UK
      handmadehands.co.uk
    6. Re:Ponce de León still searching... by Angstroem · · Score: 1
      Would be my favorite idea. Work in a field for a couple of years, then learn new/other stuff, then maybe change the entire area of work.

      Another thing is, that with people living longer (not to mention forever) the monetary system would break as everyone would be able to accumulate wealth and become filthy rich over a long enough period of time. Hence, inflation will have to rise in a similar way -- or we just switch over to a new system where unused, deposited money decays instead of accumulates.

      Not to mention societies not being based on money anymore but the fun of doing things. Star Trek universe, here we come.

    7. Re:Ponce de León still searching... by DirePickle · · Score: 1

      Because the supercentenarians might actually have to (gasp) not retire yet! This isn't about extending how long we can live on respirators, but how long we can live healthy, 'youthful' lives.

    8. Re:Ponce de León still searching... by thrawn_aj · · Score: 1
      I agree.

      [sarcasm]

      The last thing we need right now is old farts like Pat Robertson (and pretty much the entire religious right (globally, not just the US) whose mean age must be 150 :P) continuing to f*** up civilisation. It's a good thing their lifetimes are limited. Since earthly justice has never existed, perhaps the last great equalizer is the only thing saving our colective butts.

      [/sarcasm]

      As Captain Duv Galeni says in "Brothers in Arms" (Lois McMaster Bujold):

      How fortunate that science hasn't cracked human immortality. It's a great blessing that we can outlive old wars. And old warriors.
    9. Re:Ponce de León still searching... by Maltheus · · Score: 1

      How is our great-grandkids' generation supposed to support millions of supercentenarians?

      I dunno, sell drugs? Rob banks? There will be plenty of opportunities left for them. Now where's my prune juice?

    10. Re:Ponce de León still searching... by ChrisMaple · · Score: 1

      Using currently available technology and taking good care of yourself should be sufficient to delay your degradation substantially. This gives you and advanced technology a better chance to meet at a point you like.

      --
      Contribute to civilization: ari.aynrand.org/donate
  9. Yes, "... without giving up chocolate." by Anonymous Coward · · Score: 0

    Yes, "... without giving up chocolate."

    As someone who is self-unemployed, I wouldn't want to live a lot longer just to pay an additional 30-50 years of medical insurance premiums. Can't imagine what premiums would be after you passed 100-years old.

  10. Retirement age = 63 in Finland by Anonymous Coward · · Score: 0

    Just to correct you - retirement age in Finland is 63.

  11. Re:Earlier death by fsiefken · · Score: 3, Interesting

    actually that is not the case, calorie restriction (CR) makes you live longer with a positive impact on your health - including heart diseases. the only issue is the social and psychological impact such a restrictive diet has on your life. the alternative is going on an alternate day diet, or using these longlivety genes turn-on's, like resveratol. these have non of the problems - instant extra 30 years!

  12. tinfoil response by u-bend · · Score: 5, Funny

    How long do we really want these worms to live? Till they become sentient long-lived invertebrate overlords?

    --
    u-bend
    1. Re:tinfoil response by aadvancedGIR · · Score: 1

      Well, since the longer they live, the slower they evolve, I wouldn't worry too much.

    2. Re:tinfoil response by u-bend · · Score: 3, Funny

      I was just thinking that if we work on their size too, maybe they'll start producing spice and then space exploration will start getting really interesting.

      --
      u-bend
    3. Re:tinfoil response by bodan · · Score: 1

      Nah, we need foldspace engines first, and a Butlerian jihad maybe. Spice is only useful for navigation, and we still have computers.

      --
      "I think I am a fallen star. I should wish on myself."
    4. Re:tinfoil response by dim5 · · Score: 2, Funny

      Relax... they still haven't found treatment for the lay-on-the-sidewalk-until-you-dry-up gene. If they get out of hand, we'll just turn a sprinkler on them.

      --

      Is something burning?
      Oh, it's my karma.

    5. Re:tinfoil response by Zenaku · · Score: 1

      That statement would only be correct if the longer lifespan caused them to delay reproduction.

      --
      If fate makes you a motorcycle, you become a motorcycle.
    6. Re:tinfoil response by andphi · · Score: 1

      Having spice would be interesting, but I hear the withdrawal symptoms are murder.

    7. Re:tinfoil response by Anonymous Coward · · Score: 0

      Wormsign!

    8. Re:tinfoil response by noidentity · · Score: 1

      "How long do we really want these worms to live? Till they become sentient long-lived invertebrate overlords?"

      I know this was simply a joke, but it still rests on the false premise that evolution is directional (and that we humans are at the pinnacle). In fact, the worms living longer would reduce the rate of evolution. Even if it were increased, they would evolve to be...better worms.

    9. Re:tinfoil response by sunwolf · · Score: 1

      Wouldn't you want shorter lifespans for an increased rate of evolution? Then you would need to put them into an environment in which cunning and brute mammalian dominance traits are selected for.

      ...Upper management?

  13. Re:Earlier death by rbanffy · · Score: 1

    Being close almost past 40, I'd take that deal. ;-)

  14. Old News by hsquared · · Score: 2, Informative
  15. Trade-offs by Immerial · · Score: 1

    You know that there will be some sort of biological trade-off for this. Our bodies are complex systems and it is almost never a simple case of 'turn-this-gene-on-and everybody-lives-longer'. Since this seems to be related to diet, I can't imagine how bad things will turn out for the way some people eat now. We already have people that are obese without some longevity gene in the mix! (INAGBIPOOSD- INA geneticist but I play one on \.)

    1. Re:Trade-offs by robinvanleeuwen · · Score: 1

      Offcourse when you are spouting things like:

      INAGBIPOOSD- INA geneticist

      people want to know what that means... :-)

      I came as far as I Am Not A Geo Biologist (Information Politics Oriented Or... :-) )
      So don't keep us in suspense...

      --
      If you don't like my sig then don't read it.
  16. CNN Did a story about this ... by Bobosan · · Score: 1

    CNN did a special report about this a few weeks or month ago. There was a couple on there who' daily calorie count could not exceed 640 I think it was. They showed them eating tomato's for dinner along with something else, I think if was just leafy greens. Personally I could never eat that little. I only eat 2 meals a day, and sometimes skip my lunch, so I get most of my calories in one or two sittings. Even then, since I can't really cook, I either eat easily prepared food (Aka pizza rolls and hotpockets!) or grab something out on the way home. I probably only take in maybe 1600 calories, but it's the saturated fat that's going to kill me eventually. That's assuming smoking three packs a day doesn't kill me first. What was really interesting about that CNN program was they didn't talk about just living longer, they talked about improving the standard of living during your later years. After all, what goes is living another 50 years if you're strapped to an oxygen tank or bed bound? Speaking of, the moment some doctor tells me I have lung cancer, I'm going to do what the Duke did....grow gils and breathe like a fish ;)

    1. Re:CNN Did a story about this ... by knapper_tech · · Score: 1

      Something about the smoking really struck me as ironic. You could use smoking in place of eating to bump down your calory intake since smoking is effective for reducing hunger (I don't know the mechanism.) Kids in bad places do it to keep from feeling like they're starving all the time. I did it for a while in Kyoto when I was short on cash. 300yen worth of cigarettes is like 2000yen worth of food in terms of staying ahead of the hunger. Now...if only it was something other than cigarettes XD

      --
      "There are some people that if they don't know, you can't tell them." ~ Louis Armstrong
    2. Re:CNN Did a story about this ... by Anonymous Coward · · Score: 2, Funny

      There was a couple on there who' daily calorie count could not exceed 640 I think it was. Still running DOS, huh? (But who'd need more than 640 cal., anyway?)
    3. Re:CNN Did a story about this ... by jabuzz · · Score: 1

      640 Calories is a rapid starvation diet. An adult could not survive very long on that. As a benchmark they got something like 1300 Calories a day in Auswitz, 1700 Calories is doing hard labour.

    4. Re:CNN Did a story about this ... by knapper_tech · · Score: 1

      lol...sue them. The US...FDA(?) decided that people would be too confused (after the laughable failure to convert to metric?) so they opted to drop the 'k' from kcal. It's usage is so ubiquitous that people in the states have to use the term "calorie" in place of "kcal" in order for 99% of people to know what they're talking about.

      Furthermore, if suddenly the FDA decided labels should start carrying kcals, people would be confused into thinking that every meal would constitute hedonism. There would be environmentalist groups (not the respectable kind) shouting at congress to mandate the burning of fast-food for power generation following the technological advancement in the food industry that lead to a 1000X increase in energy density. You're talking about a nation that elected George Bush and Cheney...twice.

      --
      "There are some people that if they don't know, you can't tell them." ~ Louis Armstrong
    5. Re:CNN Did a story about this ... by Eddi3 · · Score: 1

      Well, 640 calories should be enough for anybody.

  17. Two things by Anonymous Coward · · Score: 0

    - You can not control life - NEVER! Even if you have all the money in the world you can not control your life.
     
    - You should aim to become retired as soon as possible. Life is ment for living, not working.

    1. Re:Two things by Phyvo · · Score: 1

      That's weird. For all of history living has meant working, because it requires work to live. Am I failing to detect sarcasm here?

    2. Re:Two things by Anonymous Coward · · Score: 0

      He probably meant to say "life is for living off others."

  18. Who Doesn't Wan't More Time? by knapper_tech · · Score: 5, Insightful

    If I could get a few more years earlier in life while I still have gobs of energy and relatively no responsibilities... Suddenly four years for a degree wouldn't seem like a huge investment. A year of study abroad in Japan wouldn't be an issue. I might have two hobbies. Long term investments would make more sense. I would take more time to learn more things, aquire more skills, and experience a broader life.

    In short, I think living longer would make it a lot easier to live sensibly. As it is, if I have to weight the risks of investing time or taking something I can do now, I end up taking the most courageous and risky courses possible.

    I don't think it's a relative thing either. Not in the sense that, regardless of whatever time-span I had, I would always wish, "Wow, if only I had twice as much." In an absolute sense, I just don't think I'll ever have the years to do all the things I want to. It makes it seem really pointless to invest eight years into something (for instance, undergrad + med-school) when it's such a large investment that, by the time I get done, I will have lost many opportunities of youth, but I couldn't put such a thing off because, who wants to invest eight years in something that will only pay off for twenty?

    Humanity is robbed. People live crazy lives because we are going to die too soon to live fully, so life is futile. Damn whatever you recognize as the determining factor of our longevity. The light is green to research like this.

    --
    "There are some people that if they don't know, you can't tell them." ~ Louis Armstrong
    1. Re:Who Doesn't Wan't More Time? by MichaelSmith · · Score: 1

      Humanity is robbed. People live crazy lives because we are going to die too soon to live fully, so life is futile. Damn whatever you recognize as the determining factor of our longevity. The light is green to research like this.

      Yes but the piecemeal approach of medicine won't get there fast enough to work for me. The only real possibility I can see is transhumanism.

    2. Re:Who Doesn't Wan't More Time? by Anonymous Coward · · Score: 0

      For those of us who are evolutionists, perhaps an extended life span would be important as you will simply no longer exist after death. But for those of us who are creationists, the time we spend here is simply a prelude to the eternity beyond this small fraction of earthly time. ;-)

      I can see the people spending a small fortune on switching on this gene, then being hit by a bus the next day.

    3. Re:Who Doesn't Wan't More Time? by knapper_tech · · Score: 1

      I honestly had to pull up wikipedia and do a quick overview just to get on the same page, as I have niether really studied into any transhumanist schools nor encountered enough of the opposition arguments to have much of a sense of where the argument exists. On it's face, however, I can say I don't feel the need for a complete overhaul. Just some basics. I'm not interested in being immune to death. I just wish I had more time so that I wouldn't feel like I'm limited on what I can accomplish with one brief lifetime. My argument for this is that our lives are too short, so short that a generation is only twenty years and there's neither time nor incentive to worry about a single life that's going to be so insignificant.

      My initial impression of transhumanism is that it's a desire to defeat a universe that inevitably kills us. To that, I'll say there are countless ways to live forever through the echoes of your life. Make an impression you want to leave.

      In response to transhumanism, I can say only this: The desire to extend the capabilities of our physical bodies is not nearly as commendible as the desire to extend the defining human characteristic and essense: will; and you can do that all by yourself.

      --
      "There are some people that if they don't know, you can't tell them." ~ Louis Armstrong
    4. Re:Who Doesn't Wan't More Time? by knapper_tech · · Score: 1

      Lol. Read my response to the transhumanist. I think you'll find more than a binary argument going on. Mathematically, living in an ideological point seperates you from being able to engage with values that exist in any other number of dimensions. (I'm have yet to ever hear of negative dimensions, but if they have been defined, I don't know of their behavior, so I can't speak to them.) Where's another place I've heard this...someone find the quote from Spock in the Wrath of Khan =D

      --
      "There are some people that if they don't know, you can't tell them." ~ Louis Armstrong
    5. Re:Who Doesn't Wan't More Time? by Peldor · · Score: 0, Troll
      You have the same amount of time (roughly 24 hours per day) as all those people you admire who do more/have more/are more/live more.

      Time is not your problem. You are your problem. Get to work on that.

    6. Re:Who Doesn't Wan't More Time? by knapper_tech · · Score: 1

      Lol. Stop making up issues for me and then maybe you can tell me something I don't know.

      --
      "There are some people that if they don't know, you can't tell them." ~ Louis Armstrong
    7. Re:Who Doesn't Wan't More Time? by Anonymous Coward · · Score: 0

      Evolutionist != Atheist Creationist != Whatever cult you belong to. Do us a favor and expidite to your "eternity beyond".

    8. Re:Who Doesn't Wan't More Time? by Anonymous Coward · · Score: 0

      You can have that extra time right this second if you decide to pause for a moment and examine your expectations and ideas. I'll hazard a guess that you feel rushed and pushed because in your mind you have a set of goals that have been thrust upon you by society. The obvious ones are stuff like "get a job", "get married", and the myriad of implications that ideas like those carry. We must be "successful", but measured against what the mainstream decrees that successful is.

      I'm not a born-again-something or new-age loony and I managed to rethink my life twice already at the age of 34. I'm not rich, I'm an employee, but I no longer feel the pressure of the rat-race and I live life at my own pace. I've switched career, I've moved to live to a different country, ditched bad relationships and started anew... The more I do this things the more I realize that I *can* do this things. Do yourself a favor and stop waiting until you retire to have fun. The reason I'm not rich -other than not being particularly interested in spending my adult life building a business- is that I'm having some fun now, traveling, buying little toys that make me happy, helping out some people that needed a hand. I do save some for my retirement, but that what I plan to do then is to give a shot to the activities that I will be too old and tired to have the energy to do at an advanced age. It is really as easy as it sounds, the hard part for me was to believe it. Some grief and a good shrink were necessary to open my eyes, but boy am I glad I did.

      Posted Anonymously because I don't want to self-aggrandize, I'd like just to give some food for thought.

    9. Re:Who Doesn't Wan't More Time? by knapper_tech · · Score: 1

      I'll hazard a guess that you feel rushed and pushed because in your mind you have a set of goals that have been thrust upon you by society. The obvious ones are stuff like "get a job", "get married", and the myriad of implications that ideas like those carry. We must be "successful", but measured against what the mainstream decrees that successful is.

      At this point in my life, I can't say there's a damned thing society can do about me :-D Still, congratulations on not going A->B->C etc. It's too early for me to see this by far, but I suspect it takes some character to move on once you feel like you've wasted time off course? Anyway, hopefully every new experience will keep proving useful, and I'll never have to say I've wasted any...okay, never mind. There are some, but at least I know how to see them coming.
      --
      "There are some people that if they don't know, you can't tell them." ~ Louis Armstrong
    10. Re:Who Doesn't Wan't More Time? by Phyvo · · Score: 1

      "To that, I'll say there are countless ways to live forever through the echoes of your life. Make an impression you want to leave."

      Even echoes fade until they can no longer be heard. If there's one thing to learn from science, it's that immortality only exists at the most basic of levels, if you can consider energy or matter as in themselves "living". I suppose that some people might be happy so long as their "echoes" exist somewhere, somehow, as information, but I obviously think that's silly. What's the point of "echoes" if no one can hear them? If they don't affect anything? Isn't that just what death is?

    11. Re:Who Doesn't Wan't More Time? by knapper_tech · · Score: 1

      Lol. Heard of Prometheus? I heard he invented fire. Like, whoah! Like, Slashdot on unicorn steroids! Anyway, the best remedy feeling compelled to write something like this is to realize that you've overextended a metaphor.

      --
      "There are some people that if they don't know, you can't tell them." ~ Louis Armstrong
    12. Re:Who Doesn't Wan't More Time? by HydroPhonic · · Score: 1

      ...Long term investments would make more sense. I would take more time to learn more things, aquire more skills, and experience a broader life. Until you get hit by the bus driven by someone who smokes two packs a day...
    13. Re:Who Doesn't Wan't More Time? by Phyvo · · Score: 1

      The knowledge of how to make fire will die with the human race. Seriously, if nothing we do affects The End, then how does anything in-between matter? Humankind will die out, and Prometheus' fire with it.

      It's not like fire couldn't have been invented by someone else, anyways. If the inventor didn't invent it that'd just mean someone else would have. In either case fire is invented and the only difference is in the name of the inventor.

  19. Population control, NOW! by Knutsi · · Score: 4, Insightful

    It's not the drugs that are the problem, it's our never-ending population growth! The more land we turn into farmland, the more kids we have, that again will need to turn new land into farmland, or squeeze even more out of what is allready there to stay alive, and have more kids that needs more farmland... and so on, so forth...

    Seriously, we know that we will crack the secrets to long life at one point or another. We know that we want to maintain a high standards of living, and achieve self-realiszation. We want there to be wild nature left. We want there to be more species that rats, cockroaches, dogs and cats living alongside us.

    It doesn't take a genious to see that a major pieces in the puzzle that is our long-term survival is population control, and we need to enact it now. Global warming is a small piece in comparison.

    To those who wish to endulge, I'd stornly reccomend Daniel Quinn's excellend books 'Ishmael', and 'The Story of B'.

    1. Re:Population control, NOW! by drsmithy · · Score: 4, Insightful

      It doesn't take a genious to see that a major pieces in the puzzle that is our long-term survival is population control, and we need to enact it now.

      We've been doing it since the dawn of time. It's called war.

    2. Re:Population control, NOW! by CaffeineAddict2001 · · Score: 2, Informative

      War generally has had little effect on population. WWII only killed 3% of the population of the countries involved (and had a subsequent population explosion). Compare to the black death which took out something like 30%.

    3. Re:Population control, NOW! by WrongMonkey · · Score: 1

      War isn't even good for that. The survivors tend to reproduce as a rate that more than compensates for the losses. See baby boom. Even the Soviet Union, which had more casualties than any other country, returned to its former population in a generation.

    4. Re:Population control, NOW! by mangu · · Score: 1
      Compare to the black death which took out something like 30%


      And about 250 years later the population of Europe had recovered and grown to the same value it would have if black death had never existed. Mass death is compensated by faster population growth afterwards, because more resources become available to the survivors.

    5. Re:Population control, NOW! by Anonymous Coward · · Score: 0

      Well.. it could done better but there are some groups who check the hands of the war makers with their wailing and whining about collateral damage, think of the innocent civilians, etc. ;-)

    6. Re:Population control, NOW! by radtea · · Score: 2, Interesting

      The more land we turn into farmland, the more kids we have, that again will need to turn new land into farmland, or squeeze even more out of what is allready there to stay alive, and have more kids that needs more farmland... and so on, so forth...

      That would explain why the amount of land farmed in North America has been falling for decades, and the population would be stable or shrinking were it not for immigration, yes?

      The fact is that by the time I am old the "population crisis" will be under-population, not over-population, at least so long as religious nutjobs don't get their way. You see, regardless of what your faith tells you "just makes sense", the fact is that increasing the status of women, and increasing urban populations (which increases wealth while decreasing ecological footprint--the most environmentally friendly place to live in North America is downtown New York City) both result in large decreases in the birth rate.

      If you want to "enact population control" you only need advocate equal rights and strong legal protections for women, and increased urbanization. Those two things, which are happening at a great rate in places like India, will moderate human population growth within a few decades. I fully expect to be alive as part of the largest human cohort that has ever existed, and it will continue to be the largest for some centuries, until we start colonizing other planets in a serious way.

      --
      Blasphemy is a human right. Blasphemophobia kills.
    7. Re:Population control, NOW! by kennylogins · · Score: 1

      "Space, the final frontier..."

    8. Re:Population control, NOW! by CFTM · · Score: 2, Interesting

      Population control would be impossible to create and maintain on a global scale; instead all we have to do is allow the natural course of supply and demand to naturally limit the population. The results WILL NOT be ideal and this mindset is somewhat callous but individual homo sapiens are meaningless on the scale of survival. As we are unable to support more people our populations will naturally be checked: diseases will run rampant, there will be massive clean water and food shortages which in turn will cause wars. All four of these things will check our population.

      Might we do a great deal of damage to the planet? Yep we sure will.
      Will the damage we do to the planet last forever? Not a chance in hell; if we manage to kill ourselves off some other species will slowly begin to take over for whatever reason. This is just how our planet works, get over it.

      Oh and don't you worry, Global Warming is going to help with population control too! I predict that there will be massive destablization in China/India within the next twenty years: partially due to global warming, partially due to over population and most of it having to do with the preference for male babies over female babies in these countries (I believe India has this same problem, please correct me if I'm wrong). As it stands today, a huge imbalance exists and this imbalance will have the greatest affect on the poorer parts of China. This is going to be a huge issue, if men can't find women there will be an amazing degree of unrest. We are really such simple creatures...it's great :)

      http://www.msnbc.msn.com/id/5953508

    9. Re:Population control, NOW! by CaffeineAddict2001 · · Score: 1

      No, that's Malthus theory. Which is incorrect. Population levels remained low well into the 16th century.

    10. Re:Population control, NOW! by CaffeineAddict2001 · · Score: 1

      Oh, nevermind, you said 250 years later. So what though? 250 years is not a remarkable time for population recovery.

    11. Re:Population control, NOW! by SevenHands · · Score: 1

      Alternatively... Soylent Green anyone?

    12. Re:Population control, NOW! by ahkbarr · · Score: 1

      Are you really this stupid?

      Do you understand that the world population is set to drastically control itself already? As less developed countries become more developed, their population growth declines because a family's stability no longer relies on having many children.

      Population naturally controls itself through scarcity anyway, and that's _way_ better than self proclaimed know-it-alls like you deciding they know how many babies families should have. It's basic biology, so crack open a book, dumb fuck.

      --
      Compared to war, all other forms of human endeavor shrink to insignificance. God, how I love it. - Gen. George Patton
    13. Re:Population control, NOW! by TheoMurpse · · Score: 1

      self-realiszation
      Can't decide if you're from the US or the UK, can you?
  20. They all got it wrong by aadvancedGIR · · Score: 5, Funny

    Healthy food does not prolonge life, it just make it seem so long and boring you want to die.

    1. Re:They all got it wrong by DrCode · · Score: 1

      You haven't been paying attention to 'anti-oxidants'. Nowadays, 'healthy food' includes coffee, chocolate, wine and beer!

  21. machine lifetime by forgethistory · · Score: 1

    Essentially a living organism is like a machine; and machines come with a certain lifespan.
    You could potentially reduce 'usage' and increase life
    I would think there is only a certain amount of resources that an organism can consume before it wears out.
    Isn't the gene that the article refers to a regulator that moderates the efficiency with which resources are utilized to maintain life?
    So we might be able to doctor the gene to process chocolate with greater efficiency
    But for some reason I cannot intuit that we are going to be able to consume unlimited quantities of food and not die from it.

    1. Re:machine lifetime by knapper_tech · · Score: 1

      I certainly can't see the body as being something so simple that it works as if each enzyme has 1,000,000,000 uses before it breaks and only 1,000,000,000,000 such enzymes can be created. There certainly could be subtle variables that influence how things operate in the sense that some conditions could cause things to operate without breaking themselves or other machinery. Even in simple o-chem experiments, altering proportions can lead to an entirely different reactions because new pathways become favorable. For something as complex as an organism, there are undoubtedly trillions of relationships between processes that can affect the efficiency or alter the outcome of another. Isolating them is of course another matter altogether, but if nature has hardcoded in something to do that work (expirimentally determining how to tweak the machine to operate less self-destructively) can't we take advantage of it?

      --
      "There are some people that if they don't know, you can't tell them." ~ Louis Armstrong
  22. Where did the funding come from? by lar3ry · · Score: 2, Funny

    Why do I have the feeling that this study was funded by the Ira Howard foundation?

    --
    "May I have ten thousand marbles, please?"
    1. Re:Where did the funding come from? by MichaelSmith · · Score: 1

      Why do I have the feeling that this study was funded by the Ira Howard foundation?

      Offhand I can't think of an example of Lazarus Long passing on his longetivity trait to his decendents. There were his two clone sisters but both were heavily engineered. So IMHO the foundation failed, because few people directly lived long lives as a result of their efforts.

      Note that I am really referring to TEFL, not Methuselas children.

  23. Very old news! by Nuffsaid · · Score: 1

    "Found", indeed! I've had this gene for a lifetime!

    --
    Nuffsaid
    ________

    Don't know about his cat, but Schroedinger is definitely dead.
  24. I wish by Anonymous Coward · · Score: 0

    Only if they could find a gene to make me look athletic without working out and despite the junk food and despite sitting in front of a computer 15 hours a day.

  25. That's correct by Tawg · · Score: 0

    "Very different lab animals, from worms to mice, live up to 50% longer"

    Ah yes, i remember reading about the long cat before.

  26. Interesting similarities by mapkinase · · Score: 5, Informative
    BBC article has a link to another BBC article about an example of a man who followed this diet:

    On a typical day, I will eat an oatmeal-based recipe for breakfast, which is about 455 calories and it gives me about half of my daily nutrients.

    I don't eat lunch - after this breakfast I just don't feel hungry - so that leaves me about 1,350 calories for my evening meal, which is a lot.
    This is very close to the dieting of the Muslims when they fast (obligatory fast during Ramadhan or voluntary fast during the month of Sha'ban, on Mondays and Thursdays, on 13,14 and 15th of each Islamic month or other recommended days).

    We have a breakfast (Suhur) before dawn and do not eat or drink until sunset. After sunset we have a usual meal (Iftar). The only difference to the diet described in this BBC article is that we do not drink while Mr. Cavanaugh does.
    --
    I do not believe in karma. "Funny"=-6. Do good and forbid evil. Yours, Oft-Offtopic Flamebaiting Troll.
    1. Re:Interesting similarities by phayes · · Score: 1

      Not eating/drinking while the sun is up has little to do with a low calorie diet.

      Most of my colleagues who follow ramadan actually gain weight during it as they eat copiously of high calorie food while the sun is down. A big breakfast to tide you through the day & a big, though late, dinner annihilates any gain you might get by not eating during the day.

      --
      Democracy is a sheep and two wolves deciding what to have for lunch. Freedom is a well armed sheep contesting the issue
    2. Re:Interesting similarities by drsquare · · Score: 1

      That's a bad way of doing things, not eating all day slows your metabolism, during the day your body will break down your muscle mass to feed itself. Then when you eat in the evening it will all be converted to fat.

    3. Re:Interesting similarities by Anonymous Coward · · Score: 0

      You forgot to mention the gorging that takes place in the evening when you break fast.

    4. Re:Interesting similarities by mapkinase · · Score: 1

      It has to do only with the example referenced in the TA (that English bloc). I thought I was clear on that.

      As for gaining weight. It is a sad truth about us, modern (in terms of time, not ideology) Muslims. It happens sometimes to myself as well.

      But this is not in any way a consequence of Islamic teaching, because there is another ruling on how much a Muslim should eat according to the example of the Prophet, sal Allahu 'alaihi wa sallam. The amount of eating during one meal in Ramadhan should not be more that usual meal during nonfasting days.

      So, again, it is not a problem of Islam, it is problem of Muslims that do not follow Islam in a right way.

      --
      I do not believe in karma. "Funny"=-6. Do good and forbid evil. Yours, Oft-Offtopic Flamebaiting Troll.
    5. Re:Interesting similarities by mapkinase · · Score: 1

      It won't break down the muscle mass to feed itself, because it will use fat instead.

      --
      I do not believe in karma. "Funny"=-6. Do good and forbid evil. Yours, Oft-Offtopic Flamebaiting Troll.
    6. Re:Interesting similarities by phayes · · Score: 1, Flamebait

      TFA is about how severely curtailing caloric input extends lifespan. It mentions someone who eats very little for breakfast, nothing for lunch & a normal meal for dinner. As you didn't mention that the only similarity between someone who severely limits his caloric intake & muslims during ramadan is that they do not eat during the day, most people who were ignorant of Islam would mistakenly believe that caloric input goes down when it is practiced. As that is certainly not the case, I felt that a correction was needed. Your getting moderated +5 proves my point. Do you honestly think that "Hey people in my religion don't eat during the day just like the guy in the article" deserves the mod points it received?

      --
      Democracy is a sheep and two wolves deciding what to have for lunch. Freedom is a well armed sheep contesting the issue
    7. Re:Interesting similarities by drsquare · · Score: 1

      No, the body uses up muscle more readily it uses fat, especially with inactivity.

    8. Re:Interesting similarities by mapkinase · · Score: 1

      Well, let me tell you this if it is of any consolation: I do not think you deserve Flamebait slapping.

      --
      I do not believe in karma. "Funny"=-6. Do good and forbid evil. Yours, Oft-Offtopic Flamebaiting Troll.
    9. Re:Interesting similarities by phayes · · Score: 1

      Stupid Mods... :-) GP was Off Topic, not Flamebait. No need to fear for my Karma. As it was posted without using a karma bonus, modding the GP down has no effect on karma. Go with God, friend

      --
      Democracy is a sheep and two wolves deciding what to have for lunch. Freedom is a well armed sheep contesting the issue
    10. Re:Interesting similarities by mapkinase · · Score: 1

      There was no mention of inactivity.

      --
      I do not believe in karma. "Funny"=-6. Do good and forbid evil. Yours, Oft-Offtopic Flamebaiting Troll.
  27. Re: by Anonymous Coward · · Score: 0

    Live long, procreate, deplete, fight, repeat...
    Hopefully, respective legislation limiting the number of dogs per family will be implemented...

  28. Re:Earlier death by Xiroth · · Score: 1

    Hey, don't worry - pretty soon heart disease won't be too much of a problem either.

    The commonly accepted path to immortality is to get rid of all the things that kill you, one at a time. This is just another step.

  29. They Shall Have Stars by Charles+Wilson · · Score: 1

    The greatest single piece of SciFi I ever read was James Blish's _They Shall Have Stars_, from the assembled epic _Cities in Flight_. Always interesting to see the RILLY good stuff have a little traction in the real world. Antiagathics first - Now on to the Spindizzies! CW

    1. Re:They Shall Have Stars by Omicron32 · · Score: 1

      Dude, what?

  30. I find it strange by Mgns · · Score: 2, Interesting

    that when confronted with the possibility of a greatly increased lifespan, say a hundred years extra, so few actually want it. Ask some people and watch their initial reaction. The ones I've queried have almost invariably argued that it would become boring.
    IMHO this stems from a belief that zest for life is NOT a biological effect, but rather a result of inexperience.

    People grow jaded with age, many even grown comfortable with their own mortality.

    I am inclined to believe that the biological decay of our bodies is a main cause of declining appetite for life.

    1. Re:I find it strange by Oxygen99 · · Score: 1

      Gah! This argument always infuriates me!

      I want longer life! I want another hundred years! I want another thousand years! Who are these people that don't want extra time? Damn them. How sadly unimaginitive. Zest for life is not the preserve of the inexperienced, it's the preserve of those with a love of culture, of learning or hell, just of life. With immortality, the true vista of human experience and knowledge opens up to you, and all you can say is bleh?

      I'll have their years if they don't, because I sure as hell can fill it and never be bored. Not for an hour, not for a minute, not even for a second. Maybe one day in ten thousand years, I might think yes, I've done enough, I'm jaded and I'm tired. My time is over. But until then screw mortality. I want to choose when I go, not capricious fate or some particulate gene who has no idea what it's like to be me.

      Science willing, one day it will be.

      --
      I had a dream, bright and carefree, but now there's doubt and gravity
    2. Re:I find it strange by Anonymous Coward · · Score: 0

      Yeah, and I bet when the average lifespan was 40 people would have thought living to 65 was boring. People are weird.

      Personally, I'll take all the life I can get (so long as I'm semi-healthy and my brain is doing OK). I love books and computer games so I very rarely get bored. I intend to spend my retirement hooked on MMOs :)

    3. Re:I find it strange by Fallingcow · · Score: 1

      I'm just hoping that I make it to that point.

      Even if it's not immortality, 200 years or so would be great.

      I'll be really pissed if I die just short of a major breakthrough.

    4. Re:I find it strange by Anonymous Coward · · Score: 0

      I can't fathom how anyone can get bored. Maybe it's the years of practice spent learning to how not to drive my mother insane (as an obnoxiously inquisitive only child), but it seems to me there's just too much to do. Right now, if I invested the time in everything I am either good at or interested in (or both), I could live until I was 500 and not run out of things to do.

      Yet I'm wary of a longer lifespan. If my body didn't stand up to its use any better, I'd just be a crotchety old person who's in too much pain to enjoy the extra time (I'm 26, and have more arthritis pain than most 50 year olds I've talked to). Not to mention the financial implications of suddenly needing to work 60 years instead of 30 to finance a retirement. Not an appealing prospect.

    5. Re:I find it strange by sohare · · Score: 1

      I think you are wrong on this one. A lot of people who come to terms with death do so because they have lived a fulfilling life. It's not so much boredom but just utter satisfaction. Won't experience that though if you don't get out much.

    6. Re:I find it strange by Nicolay77 · · Score: 1

      Ask me... I want to live for 500 years !!!!

      --
      We are Turing O-Machines. The Oracle is out there.
  31. abstract of original article by mapkinase · · Score: 4, Informative
    Abstract of original article in Nature:

    Reduced food intake as a result of dietary restriction increases the lifespan of a wide variety of metazoans and delays the onset of multiple age-related pathologies. Dietary restriction elicits a genetically programmed response to nutrient availability that cannot be explained by a simple reduction in metabolism or slower growth of the organism. In the nematode worm Caenorhabditis elegans, the transcription factor PHA-4 has an essential role in the embryonic development of the foregut and is orthologous to genes encoding the mammalian family of Foxa transcription factors, Foxa1, Foxa2 and Foxa3. Foxa family members have important roles during development, but also act later in life to regulate glucagon production and glucose homeostasis, particularly in response to fasting. Here we describe a newly discovered, adult-specific function for PHA-4 in the regulation of diet-restriction-mediated longevity in C. elegans. The role of PHA-4 in lifespan determination is specific for dietary restriction, because it is not required for the increased longevity caused by other genetic pathways that regulate ageing.
    The paper has a supplement PDF which unfortunately you won't be able to see unless your institution is subscribed to Nature. The figure S2 in it is an alignment of PHA-4 protein product to 3 most similar proteins in human. Some domains called forkhead are 85% identical, but really good alignment covers only about 90 of 506 residues of PHA-4 protein product. From my experience with proteins that qualify as orthologs, this alignment does not qualify. Homologene does not have a family of orthologs containing that worm product as well.

    It does not mean that FOXA family does not do something for our longer lives, it just mean that article does not prove that via sequence similarity. Since I enjoy "trolling" I would add that (once again) Nature capitalizes on the subject importance and publishes articles with overstretching conclusions.
    --
    I do not believe in karma. "Funny"=-6. Do good and forbid evil. Yours, Oft-Offtopic Flamebaiting Troll.
    1. Re:abstract of original article by radtea · · Score: 1


      The article also fails the mention something that all "extreme calorie restriction will make you live longer!" articles fail to mention: that all mammals except humans live about a billion heartbeats, while humans live about two billion heartbeats. So we already have anomalously long lives, which makes any extrapolation from animal models very chancy with regard to life extension.

      It will be at least a few decades before we have anything like decent statistics on the effects of extreme calorie restriction on humans, and anyone who tries this is taking a very speculative leap in the dark. Go for it if you like, but don't be surprised when you drop dead twenty years from now due to some unexpected side effect because your physiology turns out to be very different in this regard from a flatworm or a mouse.

      Population studies on the few brave, hopeful and foolish souls go this route may very well teach us something about human physiology, so even if it doesn't work for them it might do some good for the rest of us.

      --
      Blasphemy is a human right. Blasphemophobia kills.
  32. chocolate by MalHavoc · · Score: 1

    That opens up the interesting possibility that doctors may someday be able to activate that gene directly and we can live long and prosper . . . without giving up chocolate
    No one says that you need to give up chocolate. It's been shown many times that high quality dark chocolate with a high percentage of Cocoa is good for you. It's the milk chocolate that has tons of extra sugar added that isn't. And everything in moderation, right? If you want to have a piece of chocolate, go ahead - maybe skip the beer afterward. The beer is just going to ruin the aftertaste of the good chocolate anyway.
    1. Re:chocolate by ShadowsHawk · · Score: 1

      Or skip the overly sweet chocolate and head straight for the beer. Homebrew or micro brew is actually pretty good for you.

    2. Re:chocolate by Anonymous Coward · · Score: 0

      No one says that you need to give up chocolate. It's been shown many times that high quality dark chocolate with a high percentage of Cocoa is good for you. It's the milk chocolate that has tons of extra sugar added that isn't. And everything in moderation, right? If you want to have a piece of chocolate, go ahead - maybe skip the beer afterward. The beer is just going to ruin the aftertaste of the good chocolate anyway.

      That's what red wine is for.
    3. Re:chocolate by MalHavoc · · Score: 1

      Actually, really dark chocolate isn't all that sweet. I have some really rocking Lindt 99% Cocoa chocolate that's most excellent. And pretty bitter. It's amazing for things like mousses, especially with Silken Tofu (a tofu that's as creamy as cream cheese). Fantastic.

    4. Re:chocolate by ShadowsHawk · · Score: 1

      I'm sorry, but I detest Tofu. I've tried it on a number of occasions and I absolutely hate the texture (or the lack there of). Not sure why, but texture has always been a large factor for my dining experience. Mushrooms, scallops, tofu. All odd textures that I simply can not stand.

    5. Re:chocolate by ChrisMaple · · Score: 1

      I've read that the milk in milk chocolate blocks the good effects of the cocoa.

      --
      Contribute to civilization: ari.aynrand.org/donate
    6. Re:chocolate by MalHavoc · · Score: 1

      If your tofu had texture you didn't like, it wasn't cooked right. Tofu done right is supposed to be crispy, and properly seasoned. It's a moot point, though - the stuff I mentioned is like cream cheese, and is meant to be blended into mousses and sauces. It's unlike regular tofu.

      As for mushrooms. Again, most people cook them wrong. They are supposed to be cooked at high high heat, until all of the water in them is driven out. Cook them under lower heat and they just get watery and mushy because you boil them. Or grill them on a barbeque and serve them with some goat cheese, black pepper and fresh chives. Portobello mushrooms were made for that sort of thing. Marinate them in balsamic vinegar first if you like.

  33. Re:Earlier death by tomhudson · · Score: 4, Insightful

    "You can have my extended life gene when you pry it from my cold dead hands."

    Seriously, if you want to extend life, ban fructose as a sweetener. Unlike regular sugar, fructose blocks the hormones that make you "feel full" so you continue eating and drinking (esp. soda pop). 2/3 of the population is overweight, and a LOT of those are obese. Of course, a fructose ban would result in lower sales of all junk foods (because you'll "feel full" sooner), so expect it to be fought by the manufacturers, who're just fattening you up fo the slaughter.

  34. competing for food by CarpetShark · · Score: 1

    Wait 'till you're 80, pensions have long since been abandoned, and you have to compete for food with twenty year-olds who have chips in their heads, and no sense of what it means to slow down and enjoy life. Longer lifespans aren't such a nice prospect, in a capitalist culture.

    1. Re:competing for food by mfrank · · Score: 1

      When I'm 80, the 20 year olds with chips in their heads will be competing with each other to manage my retirement fund while I'm reading a book on a beach somewhere.

    2. Re:competing for food by CarpetShark · · Score: 1

      You might think so, but if everyone thinks that way, then there's competition for that beach, and you'll no longer be able to afford it ;)

  35. not only do people live longer on calorie restrict by circletimessquare · · Score: 2, Interesting

    they are also healthy and vibrant

    so your calorie restricted 90 year old is like your uncalorie restricted 60 year old

    in other words, you don't just extend lifespan, you extend the period of robust physical ability to continue working and earning a living

    in a hypothetical society where these longevity genes were activated somehow in a large segment of the population, it wouldn't be crazy to imagine retirement ages of 90 or 100

    --
    intellectual property law is philosophically incoherent. it is your moral duty to ignore it or sabotage it
  36. Live long and prosperous by coldhg · · Score: 2, Funny

    So, can we expect long lifes like vulcans have?
    Does this gene transforms our ears in pointy ones?
    ...

  37. the only way this could be a good thing by um...+Lucas · · Score: 1

    The only way that this could possibly be good is if the action of flipping that switch on (or off) turns off a persons ability to reproduce (retroactively, if need be!)

  38. Awesome! by azav · · Score: 2, Funny

    Now we can have worms that live FOREVER!

    --
    - Zav - Imagine a Beowulf cluster of insensitive clods...
    1. Re:Awesome! by Maltheus · · Score: 1

      Now we can have worms that live FOREVER!

      Might leave you with an unpleasant surprise when you finish eating that fish dinner however.

  39. Pha-4 Gene information by achillean · · Score: 2, Informative

    The article is light on any real scientific information, so for the few people that are interested in what Pha-4 is about, checkout the following link:

    pha-4 Gene Information

  40. Why would someone want to stop working? by rolfwind · · Score: 1

    Just stop working on jobs/things you don't like once you become financially secure enough. Better yet, start your own business or if that is too much stress just work what you like. That doesn't even have to be your field - could be charity or whatever.

    Waiting around to die would suck.

    1. Re:Why would someone want to stop working? by Maltheus · · Score: 1

      Waiting around to die would suck.

      Well, then I have some bad news for you...

  41. Re:Earlier death by Notquitecajun · · Score: 1

    But I LIKE Twinkies!!

  42. Highlander? by Comboman · · Score: 1
    Market forces will make it such that only the richest 3% of the population can afford the treatment.

    And those immortals will go around chopping each others heads off since "there can be only one".

    --
    Support Right To Repair Legislation.
  43. Re:Earlier death not really by hesaigo999ca · · Score: 1

    Except that you forget if your client dies early then his death is a lost sale unto you, therefor
    you should try and keep them coming longer, not shorter....I think what you meant to point out was that the McDonalds model is based on making the most money with the least expensive ingredient.
    However, if you notice after many people have made their point of view clear to them (the guy with the supersize movie) it helped put a few better things on the menu, althoutg they charge an arm and a leg for it, 8.00 a salad...sheesh....thats criminal!

  44. Re:Earlier death by oliverthered · · Score: 1

    but fructose has less calories than the equivalent sweetness of sugar, and I think it doesn't cause tooth decay (though I may be wrong on that one)

    The best answer would be to put a bit of speed in with sweet drinks so that you don't feel so hungry.

    --
    thank God the internet isn't a human right.
  45. Even *better* gene found! by martyb · · Score: 1
    From TFA:

    A study using nematode worms (Caenorhabditis elegans) revealed that a gene called pha-4 played a key role.

    The team found worms that had their pha-4 genes removed showed no enhanced longevity while on the restricted diet.

    But they discovered that the opposite experiment - over-expressing levels of pha-4 in the worms - increased longevity when on the restricted diet.

    <spinal_tap_mode>
    Big Deal. You should see what the pha-11 gene can do! :^)
    </spinal_tap_mode>

  46. Re:Earlier death not really by tomhudson · · Score: 1

    They're maximizing their profits - a dollar in hand today is worth more than a prospective dollar a year down the road, plus, over your (now shorter due to obesity) life-span, you'll end up spending several times more on pop and junk food because the fructose turns off the production of the "I'm not hungry any more" hormones.

    A government-mandated switch from fructose back to ordinary sugar would cost them more than half their sales, but it would save tens of billions in health-care costs every year ...

  47. Re:Earlier death by Jayemji · · Score: 1

    The best answer would be to put a bit of speed in with sweet drinks so that you don't feel so hungry.

    That'd really put the "coke" back in Coke.
  48. mmmm, chocolate... by drawfour · · Score: 1

    That opens up the interesting possibility that doctors may someday be able to activate that gene directly and we can live long and prosper . . . without giving up chocolate
    Sweet!
  49. Great.... by Wookietim · · Score: 3, Funny

    Oh great, now George W. Bush will live forever! The survivors will envy the dead.

    --
    http://timcol6.freehostia.com/
    1. Re:Great.... by Nutty_Irishman · · Score: 1

      What are these *survivors* you speak of?

    2. Re:Great.... by Wookietim · · Score: 1

      People who were in the tail section when the plane crashed.

      --
      http://timcol6.freehostia.com/
  50. What about Achilles' choice ? by dargaud · · Score: 1, Insightful

    So if we live 50% slower (because of energy deprivation), we actually live 50% longer. Whoah, what a great dicovery... It's exactly the opposite of Achilles' choice: either to be a great and famous hero and die young or to live a long happy life without any lasting fame. We all know how it ended.

    --
    Non-Linux Penguins ?
    1. Re:What about Achilles' choice ? by Anonymous Coward · · Score: 0

      Tyrell:
      "The light that burns twice as bright burns half as long. And you have burned so very very brightly, Roy."

        - Blade Runner

  51. Re:Earlier death by tomhudson · · Score: 4, Informative

    All sugars promote tooth decay.

    Also http://www.medicalnewstoday.com/medicalnews.php?ne wsid=65470, http://jcem.endojournals.org/cgi/content/full/89/6 /2963, http://www.sciencedaily.com/releases/2005/05/05050 3152956.htm

    Fructose depresses leptin and insulin levels. Leptin is normally produced when you eat, and this triggers the "ok, I'm no longer hungry" signal in your brain so you stop eating. Lowering the leptin level causes you to still feel hungry, even after you've eaten. Switching from fructose to sucrose will allow your body to regulate itself better.

    Its probably going to take some major lawsuits (and bankruptcies) to fix this problem ...

  52. Wonderful... by Yvanhoe · · Score: 1

    Two days ago, in a regular newspaper, I read that "A Gene Involved in Aging Has Been Found" and now, two days later on slashdot, I learnt that we have also discovered a longevity gene !
    Science really goes at a fast speed nowadays.

    --
    The Wise adapts himself to the world. The Fool adapts the world to himself. Therefore, all progress depends on the Fool.
  53. twice as long, half as bright by Lunzo · · Score: 1

    I remember seeing a documentary with some guy who was on one of those low carb diets that supposedly make you live longer. He spoke painfully slow, about half the speed of what most people do. I figured if he's living twice as long he's making up for it by going at half speed through life.

  54. 6.5 Billion people and growing by SpryGuy · · Score: 1

    The population is 6.5 billion and exploding... if everyone lived even just 10% longer, it would seriously exacerbate that problem.

    I'd rather they figure out a way to make the years we have healthier and happier.

    --

    - Spryguy
    There are three kinds of people in this world: those that can count and those that can't
    1. Re:6.5 Billion people and growing by soft_guy · · Score: 1

      Most of the "exploding" population is in the third world and they will not be able to afford this treatment anyway.

      --
      Avoid Missing Ball for High Score
    2. Re:6.5 Billion people and growing by Anonymous Coward · · Score: 0

      The solution is: don't fuck like rabid rabbits.

    3. Re:6.5 Billion people and growing by SpryGuy · · Score: 2, Interesting

      True, but imagine the population going from slowly rising in this country to rapidly rising, due to a fall-off in death rates... here in the country where each individual makes a maximum impact on the enviornment, towards energy usage, and towards waste production.

      Of course it'll level off after everyone gets the treatment, but the new established 'level' will be higher than it otherwise would be.

      I still think the emphasis should be on living better, not living longer. Do we really want the retirement age to go up to 85 or beyond? Oy. I think there would be a lot of social changes and accomodations that would be required as well. Let's not even talk about social security or anything like that, as that gets REALLY messy.

      --

      - Spryguy
      There are three kinds of people in this world: those that can count and those that can't
    4. Re:6.5 Billion people and growing by anubi · · Score: 1
      I might live longer, but will I be a productive member of society, or another welfare recipient just loading the system the productive people are burdened to support?

      What good does it do for me to live from 70 to 150, and have to expect my government to heavily burden everyone else with massive taxation to support those like me.

      When I can no longer pull my rope, let me go offline in dignity.

      --
      "Prove all things; hold fast that which is good." [KJV: I Thessalonians 5:21]

    5. Re:6.5 Billion people and growing by SpryGuy · · Score: 1

      Exactly.

      --

      - Spryguy
      There are three kinds of people in this world: those that can count and those that can't
  55. Tithonus by dargaud · · Score: 2, Interesting

    having the body of a 150 year old who would normally have died 80 years ago for 100 years is quite another. So be careful what you wish for when you ask for longer lifespans. Make sure you read the fine print first
    That's the sad myth of Tithonus
    --
    Non-Linux Penguins ?
  56. Re:Earlier death by kestasjk · · Score: 1

    Don't eat junk food; you'll die. Don't people get tired of finding things that kill them? Every day on the BBC I see either "gene found that makes old people back out of their driveway too quickly" or "toasters linked to prostate cancer".

    The life expectancy these days is longer than it has ever been, so how about spending that time doing something other than wondering how you're going to die?

    --
    // MD_Update(&m,buf,j);
  57. High fructose corn syrup by benhocking · · Score: 1

    The first thing I think of when you mention fructose is fruit - a healthy source of fructose. Of course, most people probably get their fructose from high fructose corn syrup - not so healthy. I'm just pointing out that although we probably consume too much fructose, you don't want to avoid fruit in an effort to cut fructose out of your diet altogether - just try to avoid all products that contain high fructose corn syrup. Combine that with avoiding all products that contain partially hydrogenated vegetable oil and trans-fats (the two are highly correlated but not 1:1), and you'll not only be healthier, you'll feel and look healthier too! Also, if you're a typical consumer, you'll have cut out many foods from your diet, so you're likely to lose weight to boot.

    --
    Ben Hocking
    Need a professional organizer?
    1. Re:High fructose corn syrup by Anonymous Coward · · Score: 0

      The first thing I think of when you mention fructose is fruit - a healthy source of fructose. Of course, most people probably get their fructose from high fructose corn syrup - not so healthy.

      There's nothing inherently "healthier" about fructose from fruit - it is chemically the same as fructose from HFCS.

      What's more, the ratio of fructose to glucose in the HFCS you consume is virtually the same as for table sugar - 55% fructose instead of 50%. Your body can't tell the difference, and if you eat fruit, you're getting more grams of fructose in your diet than if you replaced your table sugar with HFCS anyway.

      This is a fad-diet scare, plain and simple. The "Sugar Busters" myth was busted long ago.

  58. Re:Earlier death by Himring · · Score: 1

    "Time is the fire in which we burn. My time is running out...."

    "Time is a predator. Oh, you can delay it with medicines and doctors, but in the end it pounces and makes the kill...."

    From memory, from ST: Generations MMP, Malcom McDowell.

    --
    "All great things are simple & expressed in a single word: freedom, justice, honor, duty, mercy, hope." --Churchill
  59. People are not worms, or lab rats by Cannelloni · · Score: 1

    Besides, I don't want to live for ever. 90 years or so is enough. After that things will probably get boring and repetitive anyway.

    --
    Beauty is in the beholder of the eye.
    1. Re:People are not worms, or lab rats by Anonymous Coward · · Score: 0

      Besides, I don't want to live for ever. 90 years or so is enough. After that things will probably get boring and repetitive anyway.

      Even if this research were to lead to some astonishing longevity breakthrough, nobody's forcing you to take advantage of it. Pass on as you will. But for myself I cannot envision becoming so "bored" that death seems a good alternative. In particular, 90 years just doesn't seem all that long. Let's imagine for simplicity that one could be vital and productive the whole time between age 20 and age 90, so 70 years of living (we'll consider the first 20 to be "learning to live"). Can you fill that time with all the careers which might interest you? With all the interests and passions to which you might devote yourself? Will you have interacted with all the people you could possibly want, or have known so many that there would be nobody else of interest, that no one else could possibly bring something new? Would you have contributed all that you wish to the world? All of this and more, in a mere 70 years? Perhaps some people could be "done" with life so quickly. I'm quite certain that I could not, even in ten times that span.

      - T

  60. Surgeon General says "y'all too fat, lardbutts"! by tomhudson · · Score: 2, Informative

    "The life expectancy these days is longer than it has ever been,"

    Wanna bet? Nothing has changed in the 3 years since this, except that people have continued to get fatter ...

    http://www.surgeongeneral.gov/news/testimony/child obesity03022004.htm

    For Release on Delivery
    Expected at 2:30 PM
    on Tuesday, March 2, 2004

    Good afternoon Mr. Chairman and distinguished members of the Subcommittee. My name is Dr. Richard Carmona, and I am the Surgeon General of the United States.

    I want to take this opportunity to thank you for your service to our nation. I've had the honor of working with many of you, and I look forward to strengthening our partnerships to improve the health and well being of all Americans.

    Mr. Chairman, thank you for your leadership in children's health and education. As the nation's doctor I thank you for taking steps to combat a growing epidemic in our country: childhood obesity. By calling this hearing you are telling Americans that there is a problem and that we need to work together to solve it.

    I am joined by my colleague Dr. William Dietz, Director of the Division of Nutrition and Physical Activity at the Centers for Disease Control and Prevention. Dr. Dietz and I will be available to answer any questions you may have.

    President Bush, Secretary Thompson, and I have worked to raise public awareness of the need for a comprehensive recommitment to public health through prevention. The science is conclusive: by taking a few simple steps in our personal lives we can greatly improve our health and our nation's health, both today and in the future.

    For example, the findings of the Department of Health and Human Services' Diabetes Prevention Program clinical trial showed that people with pre-diabetes can delay and even prevent Type 2 diabetes by losing just 5 to 7 percent of their body weight through moderate changes in diet and exercise. These lifestyle changes worked for people of every ethnic or racial group who participated in the study. The changes--such as walking for 30 minutes a day five days a week--are simple, and prove that small steps can bring big rewards.

    We must increase our efforts to educate and encourage Americans to take responsibility for their own health. Over the past 20 years, the rates of overweight doubled in children and tripled in adolescents. Today nearly two out of every three American adults and 15 percent of American kids are overweight or obese. That's more than 9 million children--one in every seven kids--who are at increased risk of weight-related chronic diseases. These facts are astounding, but they are just the beginning of a chain reaction of dangerous health problems--many of which were once associated only with adults.

    Today pediatricians are diagnosing an increasing number of children with Type 2 diabetes--which used to be known as adult-onset diabetes. Research indicates that one-third of all children born in 2000 will develop Type 2 diabetes during their lifetime. Tragically, people with Type 2 diabetes are at increased risk of developing heart disease, stroke, kidney disease, and blindness. These complications are likely to appear much earlier in life for those who develop Type 2 diabetes in childhood or adolescence.

    Because of the increasing rates of obesity, unhealthy eating habits, and physical inactivity, we may see the first generation that will be less healthy and have a shorter life expectancy than their parents.

    And the economic costs of obesity are staggering--second only to the cost of tobacco use. The annual cost of obesity is now estimated at up to $117 billion in direct and indirect costs.

    The good news is that there is still time to reverse this dangerous trend in our children's lives. Today I will discuss two key factors to reduce and eliminate obesity in America: inc

  61. worms and caloric restriction: the dauer effect by sbruinsma · · Score: 5, Interesting

    Interesting study, but I'm always a bit leery of aging studies done in these worms (C. elegans), especially those which involve caloric restriction. Worms have the ability to follow an entirely different developmental path under certain conditions. Thus, normally, worms progress to adulthood and live a couple weeks. But if they are STARVED, at a young stage they shift into what is called a "dauer" state--they stop growing and can live for months and months. This is totally different than just living longer or stopping aging at a normal state--they are entering an entirely different developmental stage, which they normally would never see. Humans, of course, have no such developmental path. So with aging studies dealing with caloric restriction in worms, you have to wonder if they're studying something relevant to mammals, or if they are manipulating this worm-specific dauer pathway. It almost seems more likely to me that they would be affecting something to do with this dauer state. It will be interesting to see what happens when they follow up in mice.

    1. Re:worms and caloric restriction: the dauer effect by mdielmann · · Score: 1

      They already have, and you can be less leery. Google for mice longevity.

      --
      Sure I'm paranoid, but am I paranoid enough?
    2. Re:worms and caloric restriction: the dauer effect by Anonymous Coward · · Score: 0

      Humans, of course, have no such developmental path.

      ...How do you know? IANAB (biologist) but I've heard the line "We don't know everything about the human genome" enough times to realize that there could be modes of biology and behavior that we're only just beginning to grasp, and some we may never fully understand. Specifically, many creatures have a 'hard times' evolutionary mode which encourages survival when food is scarce and predators are stalking; why not humanity? Hell, that's what I always figured those people were doing when they ate less - invoking the "Don't die yet, remain genetically viable, everyone around you is probably dying so let's keep the species alive" gene. Starve yourself into old age and beyond. Creepy, but up to them, I suppose.

    3. Re:worms and caloric restriction: the dauer effect by anubi · · Score: 1
      Maybe an interesting study on anorexia nervosa?

      We already have a group of humans doing this... are anorexics prone to longer lifespans?

      --
      "Prove all things; hold fast that which is good." [KJV: I Thessalonians 5:21]

    4. Re:worms and caloric restriction: the dauer effect by ChrisMaple · · Score: 1

      Anorexics do not get adequate nutrition and often hurt themselves thereby. The CR meme is low calories, excellent nutrition.

      --
      Contribute to civilization: ari.aynrand.org/donate
    5. Re:worms and caloric restriction: the dauer effect by ChrisMaple · · Score: 1

      I've read in several places of caloric input being inversely related to age of menarche. (In a general sense, not a precise math formula.) While not a different type of development, this is definitely a slowing of development.

      --
      Contribute to civilization: ari.aynrand.org/donate
  62. Re:Earlier death by pla · · Score: 4, Informative

    Seriously, if you want to extend life, ban fructose as a sweetener. Unlike regular sugar, fructose blocks the hormones that make you "feel full"

    So people still fall for this one, eh?

    Newsflash - Plain ol' table sugar (aka "sucrose") contains nearly the same amount of fructose as that big-bad-boogeyman, High Fructose Corn syrup!

    Sucrose has a 50/50 mix of fructose and dextrose, while HFC contains from 43 to 55% fructose.


    But by all means, keep blaming American's fat asses on HFC rather than admitting that we simply eat way too much and exercise way too little...

  63. Oxygen consumption total =same over lifespan by spineboy · · Score: 1

    Someone I had worked with at the National Institutes of Health had looked in to those starvation diets, and saw that the animnals total oxygen use, be it the starved rat, or non-starved rat, were roughly the same at the end of their life. The fatter rats just used theirs up faster.

    Remember, oxygen is a fairly corrosive molecule, and is not necessarily good for you.

    --
    ..........FULL STOP.
  64. Lifespan by Chris+whatever · · Score: 1

    Hum i seem to recall (sorry for my lack of tech words) that cell regeneration which decreases and ultimately stop entirely is due to specific cells burning slowly.

    I once saw a depiction of those cells like small rod, strangely looked liked matches, that slowly wither and dies, they havent found a way to prevent the decay of those cells which are linked to old age.

    Diet is O.K but if you cant stop the aging process, you wont extend your life over 120 unless you live in space to lower the effect of gravity on bones.

    And dieting for the rest of your life aint a solution, healthy people die at young age as well as fat people dying at 95, we all know that fat will lower your lifespan but will it make you go over the age limit of what your body can go? i dont think so

  65. Being able to support yourself in retirement by benhocking · · Score: 2, Interesting

    Living longer would mean you need more money to support yourself in retirement, or that you need to delay retiring. The second point depends on what health state (and mental state) you're in at an older age.
    I'm already planning for retirement such that I will be able to live off the interest alone, and in such a way that I won't be living off all the interest (so that the interest will grow with cost-of-living adjustments). That way, it won't matter how long I live past retirement - the longer I live, the more money I will have to live off of. This of course is based on more than one assumption:
    • I assume that I will continue to get at least 8% annual return on my investments (on average).
    • I assume that COLAs will be no more than 2% per annum - or, more specifically, that the difference between my ROI and COLAs will be at least 6%.
    • I assume that my insurance will cover any drastic expenses that arise.
    In reality, any one of these assumptions could be violated, of course.
    --
    Ben Hocking
    Need a professional organizer?
  66. Re:Earlier death not really by Gospodin · · Score: 2, Interesting
    --
    ...following the principles of Heisenburger's Uncertain Cat...
  67. Re:Earlier death not really by freefrag · · Score: 2, Insightful

    You don't even need a mandate to use real sugar; just remove all sugar tariffs and corn subsidies.

  68. I thought "calorie restriction" study was debunked by walterbyrd · · Score: 3, Interesting

    As I understand it, those studies were done on rats. If you let a rat eat all it wants, the rat eat itelf to death in a very short time. That's where they got this calorie restriction idea.

    Thing is, rats that have a normal diet live as long as rats that have calorie restricted diet.

    Or, that's how I understand it.

  69. Re:Earlier death by osgeek · · Score: 1

    Imagine suffering through one of those CR diets for a few decades, then someone makes a cheap pill that does the same thing while allowing you to eat whatever you want. You'd feel like such a dumbass.

  70. Re:Earlier death by Phisbut · · Score: 2, Insightful

    The commonly accepted path to immortality is to get rid of all the things that kill you, one at a time. This is just another step.

    Only until Americans realize getting rid of things that kill you also means getting rid of guns, then they'll go all Second Amendment on you.

    --
    After 3 days without programming, life becomes meaningless
    - The Tao of Programming
  71. REALLY Old News (RAH) by loimprevisto · · Score: 1

    I guess this article narrows it down a bit, but we've known for decades that the longevity gene was somewhere in the 12th chromosome pair.

    http://en.wikipedia.org/wiki/Lazarus_Long/

    --
    Much Madness is divinest Sense --
    To a discerning Eye --
    Much Sense -- the starkest Madness
  72. When the Wind Blows by andellmoon · · Score: 1

    After reading James Patterson's When the Wind Blows, the topic of gene and longevity creeps me out.

    --
    - Alice, @acarback
  73. Re:Earlier death by Anonymous Coward · · Score: 1, Insightful

    The OP is thinking of Aspartame.

  74. Don't miss this part ... by Bearpaw · · Score: 1

    Still, HFCS is the current dietary demon. The Corn Refiners Association's white paper, "The Truth About High Fructose Corn Syrup and Obesity", notes the alarmist reactions lack scientific merit.
    Emphasis added.

    In other news, the Tobacco Processors Association notes that there is still some disagreement among researchers as to whether or not there's a direct connection between smoking and cancer.

  75. Think Big by 53cur!ty · · Score: 1

    No one seems to have hit on the one benefit of being able to live that long... It would enable us to travel deep into space (assuming we overcome physical problems of space travel) and truly go where no man has gone before! Everyone here seems to be thinking of a long life as one spent on the couch playing the latest video game!?! Think big and imaging the good we could all do in our extended lives.

    1. Re:Think Big by Virtual_Raider · · Score: 1

      I suspect the reason behind this is that many people don't like the current state of affairs and they go "what, an extra 100 of this crap? No thanks!" which would explain the comments about getting bored. If you had asked me this question at certain points in the past I would probably had asked you to shut up and hand me the gun. Today I would like to live for as long as I was lucid and in good health. I guess it's all about perspective, go figure.

      --
      +Raider of the lost BBS
  76. reminds me of that tune... by Anonymous Coward · · Score: 0

    "ooh, yeah, life goes on
    long after the thrill
    of living is gone"

    my doc called it anhedonia, and i'm sure it's related to my deteriorating bod:-(

  77. Ha, ha, but ... by Bearpaw · · Score: 2, Interesting
    A few years ago, for various reasons, I started eating much healthier. More whole grains, more fruits and veggies, much less preprocessed food, less fried food, etc, etc. I didn't go vegan or even just vegetarian, but I do eat less meat than I used to. (And I only eat red meat when I have an active craving for it.)

    You know what? Eating healthy takes a little more effort and attention, but it actually tastes a hell of a lot better.

    Just walking into a fast-food place now actually makes me a little nauseous. I know tastes vary -- hell, I used to love that stuff myself. But now it's, "Ye gods, how did I ever choke that crap down?"

    It's like using real maple syrup after being raised using Maple-Flavored Pancake Topping. "Oh, this is what that other stuff is pretending to be."

    1. Re:Ha, ha, but ... by aadvancedGIR · · Score: 1

      To be honest, when recycling that joke on maried men, I was thinking about tofu or other 0% fat meat substitute, not about junk or cheap fast food, which I classify as chemical waste.
      But seriously, even if you are facing overweight problems, eating has to be a pure and simple pleasure, let's say at least once a week.

    2. Re:Ha, ha, but ... by Bearpaw · · Score: 1
      Eating healthy can be a pure and simple pleasure every time.

      There are certainly occasions when I pay less attention to how healthy I'm eating, but that's not because how I eat the rest of the time is such an onerous, tasteless experience. That's simply not the case.

      The "healthy eating" = "tasteless tofu, sprouts, and granola" is an old and simplistic myth that corporate agribusiness is only to happy to encourage, while at the same time slapping a big "HEALTHY!" label on pre-packaged crap where they've replaced trans-fats with fake fats and doubled the corn syrup. Ugh.

    3. Re:Ha, ha, but ... by TheoMurpse · · Score: 1

      /. has the perspective of someone who has already been through it, now I'll offer up my experiences as someone going through the transition now. I typically have cherry tomatos for breakfast (they're quite sweet, and taste a hell of a lot better than anything else I used to eat). I munch on steamed broccoli, and during the day get a few grain servings. I only eat red meat when I visit my family (they live on a farm, and raise cattle); the rest of the time, I only eat turkey, chicken, and fish.

      I weigh 12 lbs less than I did a very short time ago, and I feel much better about myself than I did when I ate junk food. The cravings of course still come, and I eat pizza every once in a while. However, I get full a lot faster, so when I do pig out on pizza, it's significantly less than I used to eat.

      Being a university student, I used to eat fast food a lot. There is a Wendy's a quarter of a mile away from my apartment, but I haven't been there in a few months now.

      To any unattached Slashdotters out there, start eating healthily now. Find a few foods you enjoy which are healthy, and eat them every day. You'll get in a pattern of eating healthily, and because you're unattached, you won't have a wife or kids complaining about the same meal every day. That's how I started.

      And now I find out that the less calories you consume, the longer you live with youthful energy! Seriously, you'll always be saying to yourself, "Oh, I'll start eating healthily soon," but three months later, when you say it again, you may realize that you'd be 10-20 lbs lighter, with more energy if you'd just started when you said you would.

      I'm just rambling at this point because I have finals right now, so I'll just submit this comment without proofreading it.

  78. High quality chocolate is key. by Bearpaw · · Score: 1
    I eat much less chocolate now that I only eat good, dark chocolate.

    I used to be able to gobble down a half-pound of M&Ms, easy. Now, a small square or two of, say, Green & Black Mayan chocolate is great. Any more is overkill.

    It's like the difference between drinking lots of cheap beer, or one pint of really good beer. With quality, there's no need for quantity. (Unless the whole point is getting trashed rather than a little buzzed.)

  79. no by Anonymous Coward · · Score: 0

    Sucrose is a polysaccaride, a polymer of glucose and frutose. So it has to be broken down into glucose and frutose, and metabolised more slowly.

    HFCS has alot of free frutose.

    Also there are published studies showing that HFCS inhibits leptin. Which is what the OP is probably talking about.

    Now probably more studies would show its the frutose, but they do show that HFCS inhibits leptin so you need to get upto date.

    1. Re:no by Anonymous Coward · · Score: 0

      Sucrose is a polysaccaride, a polymer of glucose and frutose. So it has to be broken down into glucose and frutose, and metabolised more slowly.

      You must be joking-- sucrose is typically broken down within minutes of ingestion, hardly enough time to make a difference. Also, the glucose will cause an insulin spike, but the fructose will not. It is metabolized in the liver, without insulin.

      Also there are published studies showing that HFCS inhibits leptin. Which is what the OP is probably talking about.

      True, but the same thing happens when you eat fruit or honey. This fact doesn't shift any blame to HFCS at all. Anti-HFCS folks want to make this a simple equation of "you're fat because you eat more because you don't feel full after eating foods with HFCS," but it's just not so. Partly because they aren't actually getting as much fructose as they're led to believe, and partly because they're consuming a HUGE amount of extra calories from ingredients other than HFCS.

      Most people have no idea how many calories they are taking in, or how many they are burning. This is information you must have if you want to control your weight, fad diets notwithstanding. Would you try driving to Chicago without knowing how much fuel it takes to get there? Just pump however much you feel like using, maybe you'll get there, maybe you won't...

  80. Re:Earlier death by Mister+Whirly · · Score: 1

    ANYTHING can kill you if you try hard enough...

    But I think a good first step would be to ban Chuck Norris. Now who wants to tell him?

    --
    "But this one goes to 11!"
  81. Re:Earlier death not really by FooAtWFU · · Score: 1
    To be more specific, you can blame Hawaii for the sugar tariffs and the Republican Party for the corn subsidies. See, they're not really in league with the fast-food soda-pop types, they just want to bring home the $$$ to their constituents in the Midwest. (Not that pork is a Republican phenomenon itself, just the midwestern pork.)

    The US price of sugar is something like five times what it is on the world market.

    --
    The World Wide Web is dying. Soon, we shall have only the Internet.
  82. Re:Earlier death not really by Anonymous Coward · · Score: 0

    "you should try and keep them coming longer"

    I got an e-mail yesterday that says there's a pill that can do this...

  83. Re:Earlier death by steelfood · · Score: 4, Informative

    Sucrose is 50/50 fructose and glucose. http://en.wikipedia.org/wiki/Sucrose

    HFCS in foods is largely 90/10. http://en.wikipedia.org/wiki/High_fructose_corn_sy rup

    Only in sports drinks is the glucose content of HFCS higher than that of in sucrose.

    The wikipedia article also mentions that the most common sweetener for processed foods and soft drinks is HFCS 55 (55/45), which isn't much greater in fructose content than the 50/50 of sucrose. However, they don't mention whether HFCS 90 or HFCS 55 is cheaper to process, which would make that the more prevalent variety. Regardless, it's safe to assume that HFCS foods have more fructose than if they were to have used sugar instead.

    I'm not disagreeing that obesity is a result of eating too much and exercising too little. But what we eat also contributes to our health. And consuming large amounts of HFCS through processed foods doesn't help.

    --
    "If a nation expects to be ignorant and free in a state of civilization, it expects what never was and never will be."
  84. Re:Earlier death by Maxo-Texas · · Score: 3, Insightful

    While guns increase average deaths, in specific cases, ownership of a gun increases life span.

    If two sane people had had guns at VT or Kileen, Tx Luby's, a lot less people would have died.

    However, the average citizen tends to get angry, or has a clever child that gets a hold of the gun, or is just joking around, etc. etc. and so we get more total deaths from having a lot of guns out there.

    ---
    All that being said. The reason for the second amendment is to protect us from the government when it *inevitably* goes evil on us. They always do. They always will. When they do- hundreds of thousands or evil millions of people die really fast.

    So it is just a question of how long before you need guns to protect yourself.

    --
    She was like chocolate when she drank... semi-sweet at first and then increasingly bitter.
  85. cyborgs by BlackSnake112 · · Score: 1

    Maybe cyborgs will become a reality. Human brain with a human like robotic body. (or like that general guy from star wars, mostly robotic body with a little bit of organic on the inside) If they find a way to replace joints and limbs with stronger mechanical ones it would help all those who lost a limb. As well as people with nerve disorders who lose the use of their arms, legs, etc. (I am hoping for the second one, losing the use of the left side of my body is not fun)

  86. Re:Earlier death by TheLetterPsy · · Score: 1

    First, I thought HFCS was between 50%-75% fructose. I'm not sure.

    I use Blue Agave Nectar as a sweetener in my cup of tea in the morning. The particular product I use does not indicate the fructose level, however, a formerly used product indicated it is 83% fructose. Both products proclaimed theirs to be low Glycemic Index sweeteners. I don't feel full after having a cup of tea, however, I most certainly do not feel hungry. Although, in the interest of full disclosure, I also dip 4-5 biscuits (Bordeaux cookies made by Pepperidge Farm) in the tea and eat them. In general, I try to avoid HFCS-containing foods as I've found they cause me to feel "yucky" afterwards.

    Is the higher level of fructose in the Blue Agave Nectar worrisome? Also, as info, the tea is Yerba Mate, which is often touted as a dieting aid.

  87. Re:Earlier death by Retric · · Score: 1

    At the core of the gun ownership idea is the false premise; "I am better than average."

    While the static's on gun ownership state "Owning a gun increases your chances to be killed by firearms" people have the mistaken idea that out of 300,000,000 Americans they are likely to be involved in an attack where owning a gun will save their life. It's much the same reason people think its ok to drive 85MPH in a 65MPH zone or play the lottery.

    PS: We have already had a civil war that failed badly and now that the military has tanks, aircraft, nukes, and chemical weapons etc owning some hand guns is going to let US over through the government? Are you insane or just stupid?

  88. Escaping boredom... not hard? by Khyber · · Score: 1

    You either LIVE in the world of Slashdot, or you're just one of those kooks living inside their own head. ;) I've done things from photography to Unifill machine mechanics to computer technology to medical training, and I STILL get bored, especially when finding out that about 80-90% of my assumptions are entirely correct. Sometimes being a major bookworm to escape boredom isn't all it's cracked up to be, and I refuse to watch even the news on television.

    --
    Still waiting on Serviscope_minor to wake up to fucking reality and realize that Jessica Price isn't going to fuck him.
    1. Re:Escaping boredom... not hard? by khallow · · Score: 1

      I guess you haven't figured it out. But 200 years is a long time away. I'm optimistic.

  89. War against WHAT? by Khyber · · Score: 1

    War against what? Disease and famine combined have killed far more than any war on terrorism or fascism ever has when combined Yay influenza and smallpox! Come back to us soon!

    --
    Still waiting on Serviscope_minor to wake up to fucking reality and realize that Jessica Price isn't going to fuck him.
  90. Re:Earlier death by Phisbut · · Score: 1

    All that being said. The reason for the second amendment is to protect us from the government when it *inevitably* goes evil on us.

    For some reason, I thought your government had gone evil on you a couple of years ago. Nobody has done anything with his guns to change that though. I'm still waiting for the show

    Gun nut: I don't want no PATRIOT act or the gov'nment 'tapping my phone. Let's take our guns and head to the White House!
    Crowd of gun nuts: HURRAY!
    FBI: Yeah... I don't think it's gonna happen

    --
    After 3 days without programming, life becomes meaningless
    - The Tao of Programming
  91. wanting a gun is like wanting to be President by mkcmkc · · Score: 1

    The problem is that the people who desire to carry guns around on a daily basis (i.e., not as a part of their occupation) generally turn out to be mentally or morally incompetent to do so. Ergo, even though it sounds like allowing people to carry guns around would make things safer for all of us, it doesn't work out that way in the real world.

    --
    "Not an actor, but he plays one on TV."
    1. Re:wanting a gun is like wanting to be President by Maxo-Texas · · Score: 1

      Not at all true. I do not own or carry guns myself but I know several females who do here in Texas. Sweet, sane, nice girls all- who would blow your head right off if you needed it.

      I generally discover it when I help them move, but a couple have small guns (and concealed carry permits) in their purses. At least a couple of them practice every few months at the range. Not gun nuts- but definately concerned about their safety.

      --
      She was like chocolate when she drank... semi-sweet at first and then increasingly bitter.
  92. No by mkcmkc · · Score: 1
    Your body won't start destroying itself if you skip breakfast.

    As for the slowdown of metabolism, that may be true, but what evidence is there to suggest that this is unhealthy? It may actually be an intrinsic part of the mechanism that extends lifespan.

    --
    "Not an actor, but he plays one on TV."
  93. Not a mixture. by DogFacedJo · · Score: 1

    As an AC sibling points out - sucrose is a polysacharide.

        While it is quickly broken down by enzymes into fructose and glucose, this takes place more gradually and thus has less of an effect on satiety than direct fructose consumption from HFCS.

        Yeah, folks don't exercise enough and eat too much. You'd think we were born with some kind of urge to be lazy - as if there was selective pressure to be efficient with energy, even. ;}

        The FDA doesn't (I hope) have the mandate to enforce that folks eat less and exercise more. It *could* do something about HFCS, but the lobby is strong, and the case weak. Besides, HFCS is a US problem only, and the rest of the world has no shortage of obesity (and classic-er tasting coke).

  94. No by mkcmkc · · Score: 1
    The calorie restriction effect is heavily documented--it's real. No one really knows how it works, or what variations might work, but the basic effect has been replicated over and over. Check out PubMed.

    (I think there are some studies that didn't show the effect for certain strains or under certain conditions, which may be what you're thinking of.)

    --
    "Not an actor, but he plays one on TV."
  95. I don't want to live longer by jkiol · · Score: 1

    I just want to to die at 80-90 looking and feeling like I'm 30. THAT would be awesome.

  96. Re:Earlier death by ROBOKATZ · · Score: 1

    I also use a Blue Agave product in my morning orange juice. I do not believe it contains any fructose.

  97. Mushy, too. by Grendel+Drago · · Score: 1

    I hadn't had a fast food sandwich in a few years; I had a bite of my car-mate's, and I was amazed at how mushy it was--as if it had been designed to require as little chewing as possible. I mean, I eat sandwiches, but I usually have to chew them, you know?

    --
    Laws do not persuade just because they threaten. --Seneca
  98. Heh... by Anonymous Coward · · Score: 0

    I wouldn't expect any other than american scientists to figure out how to live longer while stuffing their face to their hearts content.

    Now we just need anti-gravity belts to fulfill the stereo-type of americans as a nation of Vladimir Harkonnens.

  99. Re:I thought "calorie restriction" study was debun by OGmofo · · Score: 1


    The short answer is no. Calorie restriction has not been debunked.

    The long answer is "pubmed", search calorie restriction.

  100. Re:Earlier death by DJAthens · · Score: 1

    Not necessarily.

    Have a look at Xylitol

  101. Re:Earlier death by AliasMarlowe · · Score: 1

    All sugars promote tooth decay. Nearly all. Not Xylitol, which inhibits growth of caries (the major agent of tooth decay). Xylitol chewing gum is actively promoted for dental health by Nordic dentists and is given to children in kindergarten the Nordic countries. http://en.wikipedia.org/wiki/Xylitol
    --
    Those who can make you believe absurdities can make you commit atrocities. - Voltaire
  102. Re:Earlier death by wizardforce · · Score: 1

    All sugars promote tooth decay
    erithritol- look it up. secondly, you seem not to be aware that sucrose is metabolised into glucose and frucfose in the body.
    what people are going to need to learn is that decreasing CALORIE intake and getting out of the house once in a while will help them lose weight. It is really sad that society doesn't understand that the problem is simple, more in than out = gain weight, more out than in= lose weight- it doesn't take a genius to figure that out.
    --
    Sigs are too short to say anything truly profound so read the above post instead.
  103. Do they tax immortals more? by phreakincool · · Score: 1

    Just asking.

  104. Re:Earlier death by GWBasic · · Score: 1

    Fructose depresses leptin and insulin levels. Leptin is normally produced when you eat, and this triggers the "ok, I'm no longer hungry" signal in your brain so you stop eating. Lowering the leptin level causes you to still feel hungry, even after you've eaten. Switching from fructose to sucrose will allow your body to regulate itself better. Its probably going to take some major lawsuits (and bankruptcies) to fix this problem ...

    I just learned that Wonderbread contains HFCS.

  105. There's no Country Buffet in Space by Maltheus · · Score: 1

    That kind of puts an end to any geriatric astronaut movement.

  106. Re:Earlier death by Pendersempai · · Score: 1

    "If two sane people had had guns at VT or Kileen, Tx Luby's, a lot less people would have died."

    Of course. The trick is sorting out who's sane. Somehow Cho slipped through the cracks. I don't know how you can be confident that more won't.

    Also, incidentally, EVEN FEWER people would have died at VT if NO ONE had guns.

  107. Re:Earlier death by Maxo-Texas · · Score: 1

    Of course, why didn't I think of that. It worked so well in britain and germany where guns were outlawed. Those massacre's didn't happen.

    Oh, I'm sorry, I didn't spout your perfect company line that if only guns didn't exist no one would kill anyone with poison, knives, by gang beatings, choking, cars, setting you on fire, etc.

    Fact is, when society breaks down in those big riots, the gun owners do better than average against mobs who do not have guns.

    However, riots, government turning bad, breakdown in social order are all rare events. Catastrophic but rare. We forget about them. And we do pay a daily cost in accidental deaths- a little less than 2 deaths per day.

    Now 12,000 people a year die from accidents- about 20 times as many as that total. And lord knows the nanny staters want to outlaw each and everyone of those causes of accidental death until we are smothered with so much protection that it is impossible to die accidentally. And that's ignoring things like smoking which are not considered accidents.

    So it comes down to: Is it worth 2 accidental deaths a day to reduce the effects of riots and tyranny when they occur once in a blue moon? It was high on our founders minds- but maybe governments going over to tyranny was more common back then. At least 30 to 40 countries including a couple big ones had this issue in the last century but less so far this century but this century is still pretty young.

    --
    She was like chocolate when she drank... semi-sweet at first and then increasingly bitter.
  108. Re:Earlier death by Maxo-Texas · · Score: 2, Insightful

    That doesn't change the basic reasons why the provision is there. We have lots of provisions and laws that become dated. Unfortunately, I agree with you that, despite their original intentions, at this point the combination of surveillance cameras, weaponry, and a fine sense of just how much they can take from us before we object means it is unlikely we could do anything.

    On other hand- if you have a gun, you can probably get a machine gun. And indirect attacks so successful in Iraq would be equally effective here. And, the army is no where near big enough to take on an entire population armed even with hunting rifles and being sneaky.

    --
    She was like chocolate when she drank... semi-sweet at first and then increasingly bitter.
  109. Re:Earlier death by Maxo-Texas · · Score: 1

    It's kinda relative. Some places like Darfur, it's pretty obvious.

    But even in Germany, a lot of the populace had no problem with 2-3% of the population being slaughtered.

    The powers that control large first world countries currently prefer to coerce rather than outright kill people. We are essentially all slaves though through a combination of tax and health methods which mean we have to do their work every day of our life until we are too old to enjoy life.

    --
    She was like chocolate when she drank... semi-sweet at first and then increasingly bitter.
  110. Intermittent Fasting by Anonymous Coward · · Score: 0

    There may be a way to activate those genes without caloric restriction... someone noted that in the original experiments with mice, calories were restricted by only feeding the mice every other day. Someone decided to see what effect the timing would have if the mice were allowed to eat the same amount as the control group, but half as often: http://www.pnas.org/cgi/content/full/100/10/6216

  111. statistics by N3wsByt3 · · Score: 1

    The only way that 3% of the richest people in any given population would be mainstream, is when the average discrepancy (of money/income) between the poorest and the richest people would be marginal when measured at the fifth percentile of that population curve, and thus one has a population where the vast majority of the people is equally rich. It is higly unlikely that 50% (in numbers) of the populace would be within the 3% of the richest percentile (in money).

    Even communism didn't achieve that, and capitalism certainly didn't. Even populations with a big middle-class have an average discrepancy that is hundreds of percentages wide. In fact, I never heard of any society like that. When we look at 'The Structure of Social Stratification in the United States' we see that the upper class (with a networth of more then $5.000.000 for an individual) is estimated between 4-6% of the populace (in numbers). This is orders of magnitudes more then the rest of the populace at the fifth percentile. So, no, they are NOT mainstream, and no, I do not know 4-5 multi-milionaires fairly well, let alone the name of their dog.

    In more socialised countries (like in europe) it may include the higher middle class, but in the USA it definately would mean only the upper-class would get the treatement. And the upperclass is by definition not mainstream, nor is it ever a large part of the populace, and thus, most people will not know 4 or 5.

    Ofcourse, I don't know the kind of circles you move in, so I can't speak for you, but as a general statement, your argumentation and conclusion was wrong.

    --
    --- "To pee or not to pee, that is the question." ---
  112. Re:Earlier death by tomhudson · · Score: 1

    Sugar from sugar cane and beets are dissacharides - fructose is a monosaccharide. Dissacharides don't depress insulin and leptin levels - they increase insulin levels.

    So please don't buy into the food industry bullshit about fructose not being responsible, and being benign. Its making you fat.

  113. Re:Earlier death not really by tomhudson · · Score: 1

    More food industry bullshit - sugar made from sugar cane and beets is a dissaccharide - fructose is a monosaccharide. The body treats them differently - disaccharides don't depress the levels of insulin and leptin - monosaccarides do - which is why you continue to feel hungry even though you've taken in a gazillion calories in fructose.

  114. Re:Earlier death by tomhudson · · Score: 1

    Almost everything does - its cheaper, thanks to farm subsidies for corn.

    Hey, maybe we can get Celine Dion to split a loaf of Wonder Bread with Ally McBeal?

  115. Re:not only do people live longer on calorie restr by evilviper · · Score: 1

    in other words, you don't just extend lifespan, you extend the period of robust physical ability to continue working and earning a living

    Except people on an (appropriate*) calorie restricted diet can't EVER do any significant physical activity. Even at 20 years old, they can't run, lift anything remotely heavy, or any other physical exertion. First, because they'll pass out, and second because the calorie restriction means they have extremely little muscle mass.

    *The 2000 calorie diets being mentioned don't count, unless you're more than 7 feet (2.2 meters) tall. The life-lengthening benefits of calorie restriction require almost 50% lower (than ideal/accepted) caloric intake, not 40% lower than an obese person's diet.
    --
    Slashdot gets worse every day... Pipedot: News for nerds, without the corporate slant
  116. Re:I thought "calorie restriction" study was debun by evilviper · · Score: 1

    As I understand it, those studies were done on rats. If you let a rat eat all it wants, the rat eat itelf to death in a very short time. That's where they got this calorie restriction idea.

    That's so horribly, completely, and totally incorrect, I can't imagine where you even got that idea from.

    Thing is, rats that have a normal diet live as long as rats that have calorie restricted diet.

    Not true, at all.

    --
    Slashdot gets worse every day... Pipedot: News for nerds, without the corporate slant
  117. Re:Earlier death by evilviper · · Score: 1

    Only until Americans realize getting rid of things that kill you also means getting rid of guns, then they'll go all Second Amendment on you.

    Bullshit. The number of deaths due to car accidents is astronomical compared to deaths by firearms. Deaths by knives are far higher than deaths by guns, and as much as I'd like not to die, I'd much more like to be able to cut up and prepare food while I'm alive... Accidents with tool cause more deaths than with any weapons. Hell, otherwise innocuous (heavy and blunt and/or just pointy) objects cause more deaths than weapons.

    I can't wait until someone tries to outlaw stairs. You'll have to pry them from my cold, dead, feet.
    --
    Slashdot gets worse every day... Pipedot: News for nerds, without the corporate slant
  118. It's not a joke, whether you were kidding or not by shpoffo · · Score: 1

    Chocolate in itself isn't bad for you; all the sugar (and often milk) that is put in is hte bad stuff.

  119. Excellent Headline by AP31R0N · · Score: 1

    +1 TMBG Reference

    --
    Utilizing the synergization of benchmark e-solutions to pre-workaround action items!
  120. Consumption of Airborne Bacteria Viruses for Food by ImitationEnergy · · Score: 0

    This article is missing some points so I guess I'll fill in for ye. When you lower your food intake it turns on a dormant ability we all must surely have, but we never use it. Food is too plentiful so we overeat. In overeating we deny ourselves from turning this "engine" within us to On. Call it the I WANT TO LIVE ENGINE. When we cut back on our food intake our body begins to consume whatever we breathe in, so when we breathe in viruses, molds, bacteria our body becomes a food scavenger and consumes all the little critters for food.

    That's why this article is misleading. It is saying those people are not getting the food energy required, but they are. The beauty of it is though that in consuming the airborne microorganisms those people are burning the infectious disease organisms as a Food Source. hahahaha Their body isn't just eating well, it is giving them a longer lifespan of Freedom from Diseases caused by the consuming of disease organisms that are proliferating inside the rest of us.

    Now you take these cancerous growths & malignancies. People have been conditioned to fear cancer. But what if those cancers are the normal cells that are trying to LIVE FOREVER and have discovered the way to overgrow? Our entire medical healthcare community is killing the cells that have discovered the superenergy secret that could give us everlasting life. It isn't about Anger; it's about Peace. An afraid mind is a closed off mind. Open yourself to the possibilities that the old dude sitting in the cell next to yours for the past 40 years has the map of escape > http://www.newpath4.com/40yearstolife.htm by facing your enemy, facing your greatest foe. Sometimes, many times, our greatest foe is us, our quiver-load of preconceptions about religious folk for instance.

    Ever since I fell out of the truck in 1986 because a pharmacist left the Warning Labels off a new drug called Meclofenamate, and then got hit by a 1,000 lb. bale 3 times because it bounced on me, I've been trying various nutrition products in an attempt to get some body energy back, maybe return to work, make a few bucks, help my family some. The answer I have found is to try and restore cellular function. Several months ago I found out that Acetyl-L-Carnitine helps restore cell mitochondria. I've been taking it about 2+ months and it has helped a good deal. I've been able to do more housework. At 55 years of age after a lifetime of serious accidents and a drowning, I try to not get upset if I never get my energy back then so be it. In 2006 I tried Nitroxy 3. It hit me with an awesome tiredness in my neck and shoulder muscles that was indescribable. I felt so incredibly WASTED that even now I still feel it, 15 months later. I recently bought a piece of bungey cord and using it for stretches. Yesterday I was researching about products that would give my body more Oxygen. Maybe the shortage of oxygen is why I have not been getting the energy needed to drag this 280 pound body around eh? Here's the link > http://www.healingedge.net/store/more_oxyoxc.html and another one > http://www.rense.com/products/oxy-c1.htm . A low oxygen state could very well be why the Acetyl-L-Carnitine has had a limited success so far. Those pages have plenty of product information. It seems there's a product called Magnesium Peroxide that has peroxide and some ozone {H2O2 & O3} locked and binded with Magnesium, so when you take a capsule and it hits the stomach it releases those inside and it enters the bloodstream. It is unfortunate for us living today, eating all this tasty food, thinking we have EVERYTHING, when it is the everything that robs us of what oxygen we have. Eating excess food instead of breath-consuming the airborne disease organisms robs us

    --
    Industrial Age 2 + How-to Stop Malignant Cancers.
  121. Re:Consumption of Airborne Bacteria Viruses for Fo by ImitationEnergy · · Score: 0

    Whew, left out a few important facts. The Magnesium Peroxide releases hydrogen peroxide and ozone into the stomach on contact with water but they do not enter the bloodstream as that. The ozone converts to hydrogen peroxide and both peroxides release an atom of Oxygen, which enters the bloodstream. After it of course also kills a whole bunch of germs. On those pages I referenced there are testimonials of people who got an immediate increase of energy the very day they took the first pills.

    Like I said, I haven't ordered it yet. Wouldn't matter anyway since we are into the weekend already... I have been pursuing this hydrogen peroxide answer to low body energy for over a year now. These webpages say Magnesium Peroxide capsules each contain the equivalent of 12 drops of Food Grade Hydrogen Peroxide... and is a better source of it than drinking the liquid. I plan to find out.

    --
    Industrial Age 2 + How-to Stop Malignant Cancers.
  122. Re:Earlier death by Ididerus · · Score: 1

    Ah! but we have the option to raise ourselves above this. While most people are perfectly happy to work at a "job" their entire life to obtain "retirement" (which means less and less everyday), some of us work hard to set a life up that is not tied to a "job". We, as Americans, are fully entitled to buy a small farm in the hinterlands and exclude ourselves from "society" and "pop-culture".

    Mr. Marley said it right:

    "Emancipate yourselves from mental slavery;
    None but ourselves can free our minds."

    Oh, and to maintain topic, die when we damn well please

    --
    I'm fighting The War on Drugs!
  123. Re:Earlier death by Anonymous Coward · · Score: 0

    > Sugar from sugar cane and beets are dissacharides - fructose is a monosaccharide. Dissacharides don't depress insulin and leptin levels - they increase insulin levels.

    Dissaccharides have to be broken into monosaccharides before they can be digested, so you're getting fructose anyway. The other ingredients you are eating at the same time (assuming you're not eating pure sugar) will cause an insulin spike anyway. HFCS by itself is not going to keep you feeling hungry after you've eaten.

    > So please don't buy into the food industry bullshit about fructose not being responsible, and being benign. Its making you fat.

    Sorry, the science says otherwise.

  124. Re:Consumption of Airborne Bacteria Viruses for Fo by ChrisMaple · · Score: 1

    Be careful with hydrogen peroxide. Read the Material Safety Data Sheet (MSDS). If you get abdominal cramps, you've likely swallowed too much peroxide.

    --
    Contribute to civilization: ari.aynrand.org/donate
  125. Re:Earlier death by ChrisMaple · · Score: 1

    Inositol - considered by some to be a B vitamin - tastes just like sugar and doesn't promote tooth decay. I believe it is actually an alcohol, not a sugar, but it looks like sugar.

    --
    Contribute to civilization: ari.aynrand.org/donate
  126. Re:Earlier death by ChrisMaple · · Score: 1
    Do not go gentle into that good night,

    Old age should burn and rave at close of day;

    Rage, rage against the dying of the light.

    Dylan Thomas

    --
    Contribute to civilization: ari.aynrand.org/donate
  127. Re:Consumption of Airborne Bacteria Viruses for Fo by ImitationEnergy · · Score: 0

    Thank you Chris! I ordered magnesium peroxide, which is dehydrated liquid peroxide bound to a fine magnesium powder til the capsule dissolves. The page says each of the capsules has the equivalent of 12 drops of hydrogen peroxide. It has a little ozone (O3) in it and when it breaks down it reverts to peroxide also. Both sources of peroxide release one atom of Oxygen, a so-called singlet atom, per each molecule. There is one possible side effect they say of getting some loose bowel effect. I don't plan to take but one at a time possibly twice a day til I find out what it does exactly. I'm sure it won't be as bad as that stomach virus that hit me in the Spring of 1979, if you ever heard of it. It hit Richmond Virginia like a toilet paper convention. Thanks for the concern. You're good people.

    --
    Industrial Age 2 + How-to Stop Malignant Cancers.
  128. Me. by Explo · · Score: 1

    Personally, I have hard time understanding why many people would not apparently accept a longer life than the current default. After all, one doesn't have to look back very far in time for the period, when just a few people even lived up to the age of 70 years and average life expectancy was around 30 years. Currently, most people in your average industrialized country can look forward to seeing that milestone and even still having a few good years left before the risk of needing nurses for everything becomes very probable.

    While a significant portion of the increased average can be explained by the massive decrease in infant mortality, the improvements in medical care have also increased the length of healthy lifespan noticeably. In medieval times, I'd by now (I'm in my mid-thirties) probably be missing several of my teeth, have caught several more potent sicknesses, and in case of accidents, have higher probability of suffering the rest of my life from the effects of poorly mended injuries. I'd assume that given the option of probably having almost twice longer life with several decades of actually reasonably healthy additional time, quite a few medieval people would have gladly accepted the offer. So, as long as the additional time also increases the length of reasonably healthy life, why should I limit myself to the current figures?

    (Regarding the idea of not really being able to figure out what to do with the additional time, that's completely weird concept to me. I've personally felt for a long time that there is far more to do than I seem to have time for. Perhaps I would change my mind after a few thousands of years, but almost certainly not with a few more decades.)

    --
    Everyone who makes generalizations should be shot.
  129. Re:Earlier death by tomhudson · · Score: 1

    Again ... the process of breaking down the dissacharides raises the levels of leptin and insulin, whereas ingesting fructose does the opposite. The science is clear - your defense of fructose by saying its a byproduct is "junk science" - studies show the body doesn't act the way you assume it does.

    Your theory sounds good, but it flies in the face of facts, facts that clearly show that fructose should not be used as a food additive.

  130. Re:Earlier death by mrkun · · Score: 1

    "Studies that have compared HFCS to sucrose (as opposed to pure fructose) find that they have essentially identical physiological effects. For instance, Melanson et al (2006), studied the effects of HFCS and sucrose sweetened drinks on blood glucose, insulin, leptin, and ghrelin levels. They found no significant differences in any of these parameters." http://en.wikipedia.org/wiki/Hfcs#Health_effects

    --
    I'm not interested in watching TV on my phone for the same reason I'm not interested in having a shit in my tumble drier
  131. Re:Earlier death by tomhudson · · Score: 1

    Try this on for size:

    http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd= Retrieve&db=PubMed&list_uids=15181085&dopt=Citatio n>?

    Dietary fructose reduces circulating insulin and leptin, attenuates postprandial suppression of ghrelin, and increases triglycerides in women.
      Teff KL, Elliott SS, Tschop M, Kieffer TJ, Rader D, Heiman M, Townsend RR, Keim NL, D'Alessio D, Havel PJ.

    Monell Chemical Senses Center, University of Pennsylvania, Philadelphia 19104, USA.

    Previous studies indicate that leptin secretion is regulated by insulin-mediated glucose metabolism. Because fructose, unlike glucose, does not stimulate insulin secretion, we hypothesized that meals high in fructose would result in lower leptin concentrations than meals containing the same amount of glucose. Blood samples were collected every 30-60 min for 24 h from 12 normal-weight women on 2 randomized days during which the subjects consumed three meals containing 55, 30, and 15% of total kilocalories as carbohydrate, fat, and protein, respectively, with 30% of kilocalories as either a fructose-sweetened [high fructose (HFr)] or glucose-sweetened [high glucose (HGl)] beverage. Meals were isocaloric in the two treatments. Postprandial glycemic excursions were reduced by 66 +/- 12%, and insulin responses were 65 +/- 5% lower (both P < 0.001) during HFr consumption. The area under the curve for leptin during the first 12 h (-33 +/- 7%; P < 0.005), the entire 24 h (-21 +/- 8%; P < 0.02), and the diurnal amplitude (peak - nadir) (24 +/- 6%; P < 0.0025) were reduced on the HFr day compared with the HGl day. In addition, circulating levels of the orexigenic gastroenteric hormone, ghrelin, were suppressed by approximately 30% 1-2 h after ingestion of each HGl meal (P < 0.01), but postprandial suppression of ghrelin was significantly less pronounced after HFr meals (P 0.05 vs. HGl). Consumption of HFr meals produced a rapid and prolonged elevation of plasma triglycerides compared with the HGl day (P < 0.005). Because insulin and leptin, and possibly ghrelin, function as key signals to the central nervous system in the long-term regulation of energy balance, decreases of circulating insulin and leptin and increased ghrelin concentrations, as demonstrated in this study, could lead to increased caloric intake and ultimately contribute to weight gain and obesity during chronic consumption of diets high in fructose.

  132. Re:Earlier death by mrkun · · Score: 1

    That's discussing fructose vs. glucose (monosaccharides), not HFCS. HFCS is a disaccharide with a ratio of 55% fructose (hence the "high" designation)/45% glucose, while sucrose (regular table sugar) has a 50/50 ratio.

    --
    I'm not interested in watching TV on my phone for the same reason I'm not interested in having a shit in my tumble drier
  133. Re:Earlier death by Anonymous Coward · · Score: 0

    That's discussing fructose vs. glucose (monosaccharides), not HFCS. HFCS is a disaccharide with a ratio of 55% fructose (hence the "high" designation)/45% glucose, while sucrose (regular table sugar) has a 50/50 ratio.

    Ummm.... no. HFCS is not a disaccharide, it contains a mixture of glucose, fructose, and other ingredients. You understand that a disaccharide is a molecule of two bonded monosaccharides, right?

    You can bond glucose with glucose, fructose with glucose, or galactose with glucose. AFAIK, HFCS doesn't contain any galactose, so any disaccharides in it are probably sucrose molecules.

  134. Re:Earlier death by Anonymous Coward · · Score: 0

    Interestingly enough, a study was just published which investigated fruit juice and obesity in children. They found that "contrary to popular belief, drinking pure 100 percent fruit juice does not make young children overweight or at risk for becoming overweight," even among kids who drank a LOT of juice.

    Fruit juice is loaded with fructose, yet it's not making the kids fat. If your claims about fructose are true, then why is this the case?

  135. Re:Earlier death by tomhudson · · Score: 1

    These kids weren't drinking "a lot" of fruit juice

    Did you even READ the article?

    "The average daily consumption of pure fruit juice in the study population was 4.1 ounces (about half a cup) -- an amount in line with recommendations from the American Academy of Pediatrics.

    .. half a cup - that's 45 calories. Not even half an Oreo cookie.

    Even if they were to drink 4x as much, that's still pretty much nothing in comparison to what the average kid is drinking in terms of soda pop ... a 2 litre bottle of coke is 770 calories - and a lot of kids are drinking a 2 liter a day.

    http://www.unc.edu/news/archives/sept04/popkin0916 04.html

    The study is from 6 years ago .. and even then, it notes that under-reporting of soft drink and "sweetened beverages" - another term for junk calorie drinks like gatorade and "sports drinks" that contain little if no "real fruit juice" is a problem.

    Fat people lie about how much they eat. They loie to themselves, they lie to their friends, their doctors. There was a study published in Scientific American (before the web) where they placed FREE vending machines in a room and let people eat as much as they wanted. They monitored who ate what, and the fatties continually SEVERELY under-reported whatthey ate.

    Why not stop trolling (4 or 8 ounces of OJ is NOT a lot) and look in the real world ... take a visit to your local supermarket checkout and look at all the fat people and what's in their shopping baskets. Then look at their kids ... the next generation of over-sugared, over-salted fatties.

    Some of these people are so fat I can't imagine how they take care of basic bodily functions like wiping after they've used the toilet. How can they reach when they're so BIG and their arms are like overstuffed sausages. How does the toilet not break under all that weight?

    Or maybe they don't, and these are the people who are buying all those adult diapers.

    Think about the damage heavily sugared and equally heavily salted soft drinks are doing. Who's defending this shit? Just follow the money ... fast fod joints, soda pop manufacturers, others who are already fatty faty 2 by 4's, can't get through the bathroom doors, and want some (preferrably even fatter) company, so they don't look so fat themselves in comparison.

    Its easier to feed the kids dogs, tater tots, and a coke and not miss that "must see" crap on the tube than it is to actually take 20 minutes to make a decent meal.

    What's served for breakfast in most homes is a crime. A bowl of cereal is not breakfast. Take the time to start with a decent, REAL breakfast, and maybe kids (and adults) won't be so interested in scrounging for those extra junk calories all day.

  136. Re:Earlier death by Anonymous Coward · · Score: 0
    Did you read the article? Maybe you missed this part:

    ...while there were a few children (13 percent) who consumed larger amounts of juice (12 ounces or more), their increased intake was not associated with overweight or at risk for being overweight. In fact, children in the 2- to 3-year-old category who drank the most juice were nearly three times less likely to be overweight or at risk for overweight than children who drank no juice at all.

    Because the kids are drinking a lot of soda and eating a lot of junk food, of course they are getting fat. Stop trying to blame it on HFCS.

    All that happened here is that people (like Dr. Robert Lustig) have pointed the finger at fruit juice as a reason for increased childhood obesity, and this study debunked it. Lustig says it's not our fault that we and our children are getting fat, it's the food products. He's wrong; the reason is that we're not limiting the calories we and our kids take in, whether they contain HFCS or not.

  137. Re:Earlier death by Anonymous Coward · · Score: 0

    Some of these people are so fat I can't imagine how they take care of basic bodily functions like wiping after they've used the toilet. How can they reach when they're so BIG and their arms are like overstuffed sausages. How does the toilet not break under all that weight?

    Or maybe they don't, and these are the people who are buying all those adult diapers.

    Think about the damage heavily sugared and equally heavily salted soft drinks are doing. Who's defending this shit? Just follow the money ... fast fod joints, soda pop manufacturers, others who are already fatty faty 2 by 4's, can't get through the bathroom doors, and want some (preferrably even fatter) company, so they don't look so fat themselves in comparison.

    Oh, I beg your pardon. When I started arguing facts, I mistakenly assumed I was dealing with a rational person and not a fitness Nazi.

    Your hatred of fat people is palpable. You must be terrified of becoming one some day. I'm sure you won't rest until all fat has been eliminated from our purified society.

    </godwinslaw>

  138. Re:Earlier death by tomhudson · · Score: 1

    You're ignoring the fact that HFCS depresses the "I'm full" signal, which is why taking in lots of HFCS makes people eat more junk food - they feel hungry because their bodies tell them they aren't full even when they've already eaten enough. Taking in the equivalent of 60 glasses of OJ of fructose is going to screw up anyone's metabolism.

  139. Re:Earlier death by tomhudson · · Score: 1

    I'll repeat it: Think about the damage heavily sugared and equally heavily salted soft drinks are doing. Who's defending this shit?

    The junk food manufacturers like HFCS because it makes you feel even more hungry. Eliminate the HFCS and people will start getting healthier. Or do you think that people actually WANT to be overweight? What sort of fucktard are you?

    And yes, people ARE responsible for what they put in their mouths. When

    1. you have more chins than Mount Rushmore,
    2. you were offered a starring role in "The Titanic" - as the iceberg,
    3. you're one of the landmarks on both Google Maps AND Visual Flight Rules charts,
    4. the scale says "one at a time, please",
    5. people get nervous when you get on an elevator,
    6. you can't see your feet,
    7. you can't reach around to wipe your arse properly,
    8. you have to literally roll out of bed in the morning,
    9. you have to have your steering wheel changed to a small custom wheel because otherwise you don't fit,
    10. your shoes split after a week,
    11. the "all-you-can-eat" says "no - you take doggy bag and go home now",
    12. you can't get clean because a shower only gets the top half (the rest is in "fat shade land"),
    13. the post office issues you TWO zip codes - one for each "cheek",
    14. you suntan and people complain about the smell of rancid cooking oil,
    15. the police give you a ticket for not having a backup alarm - and you were walking,
    16. Jabba the Hut asks you to stand beside him, so he'll look skinny by comparison,
    17. you have more garbage each week than any three other families on the street,
    18. you drive an SUV because that's the only vehicle that you fit in,
    19. you cannonballed into the pool - and emptied it,
    20. you cannonballed into the ocean - "SURFS UP!"
    21. the escalator grinds to a halt when you step on it ...
    you have to take part of the blame too, because you didn't just "get that way" suddenly. You ATE that elephant, one mouthfull at a time.

    People want to lose weight but they don't want to do the ONE thing that would succeed - shutting their pie-holes. Go in line at the supermarket and see what the fat people buy. Shit I wouldn't feed my dogs. Nobody's got a gun to their heads forcing them to spend their money on it. They're so fat that they have a hard time breathing, but don't you get between them and their Doritos.

    When I see a family of four, and together they weigh more than 3/4 of a ton (I kid you not - I couldn't believe it - wish I had had my cell phone with me so I could take a video) and they have 3 shopping carts overflowing with JUNK JUNK JUNK, they are part of the problem. They want their "fix", same as any other crackhead. But for the lesser cases, removing HFCS from the diet would be the deciding factory in getting their weight back to normal.

  140. Re:Earlier death by Anonymous Coward · · Score: 0

    > You're ignoring the fact that HFCS depresses the "I'm full" signal, which is why taking in lots of HFCS makes people eat more junk food

    There's only circumstantial evidence that HFCS makes people eat more junk food. There is direct evidence that using HFCS instead of sugar makes NO DIFFERENCE in the amount of calories people consume, or how much weight they gain.

    You're forgetting why they started using HFCS in the first place -- it's essentially the same glucose/fructose ratio as table sugar, and is much cheaper. Dieticians (at NIH, no less) have said that your body cannot tell the difference.

    Maybe the reason people are eating more junk food is that HFCS made it cheaper to buy more?

  141. Re:Earlier death by Anonymous Coward · · Score: 0

    > Taking in the equivalent of 60 glasses of OJ of fructose is going to screw up anyone's metabolism.

    I don't know where you're getting your numbers, but a 12 oz. can of soda has about 40g of sugars, and 55% of that is about 22g of fructose. By contrast, 12 oz. of orange juice contains about 32g of sugars, about half of which is fructose (16g). That means 60 glasses of OJ of fructose is about 43 glasses of soda, and I don't think even your "fatties" are drinking that much.

    > Eliminate the HFCS and people will start getting healthier.

    Fine, except that obesity is also increasing in some countries where they don't use HFCS, plus obesity continues to rise as HFCS consumption decreases. Why is that?

    > And yes, people ARE responsible for what they put in their mouths.

    Then why are we having this argument? Do you want to put the blame for obesity on the food manufacturers or not??

    > do you think that people actually WANT to be overweight? What sort of fucktard are you?

    Hey, I'm not the 'fucktard' making fun of fat people. You're not only blind to facts, you are a thoroughly insensitive asshole zealot.