Gene Found to Explain Repeated Mistakes
palegray.net writes "A December 6th article in Nature explores the relationship between a specific gene and those of us prone to repeatedly making the same mistakes. From the article: "Drug addicts, alcoholics and compulsive gamblers are known to be more likely than other people to have this genetic mutation ..." The gene results in the development of fewer D2 receptors in the brain, a condition which the study has shown leads to a lessened ability to learn from experience." So no complaining about dupes and typos: it's genetic!
The gene that controls the impulse to tell others what to do, when it isn't necessary to tell them what to do. The 'busybody' gene.
Now I know why so many politicians get re-elected: Too few D2 receptors in the voting population.
Well, thanks to the Internet, I'm now bored with sex.
When our society already has plenty of excuses to avoid personal responsibility (e.g. overdiagnosis of ADD to include kids who are just undiscipled), we give more ammunition to people who just don't want to try to get it right.
From TFA: "Dopamine is responsible for signalling fun and pleasure in the brain. But dopamine also helps us learn. When we make a pleasurable decision, dopamine is a chemical treat, urging the brain to repeat the choice. Being deprived of such a treat should theoretically activate D2 receptors and encourage people not to make that same decision again."
Is it only me who thinks that the writer did not learn to stop?
CC.
TaijiQuan (Huang, 5 loosenings)
I'm mighty hungover and they won't announce my lottery winning until Wenesday
Just look at the ad state of the World. What we would need is people that can learn from other's mistakes, but what we have seems to be a majority that cannot even learn from their own.
Back on topic, I think this is very interesting reaearch. Dare one even hope for the possibility of a cure?
Most ACs are not even worth the keystrokes to insult them. Be generically insulted by this and ignored otherwise.
This article will be duped. Be sure of it.
Ninjas and pirates. How piquant.
I wonder how long until people found to have this gene are given higher insurance rates (or harder time getting jobs if it's known).
Now some of them may very well earn them, but others don't. How long until even having the gene becomes a liability, even if it doesn't seem to affect your actions.
I'll wait for the next one to _actually_ comment.
But isn't this almost the definition of stupidity?
Deleted
And if so does this mean they get special parking? I hope not...
Or maybe people with fewer D2 receptors were more cynical by nature, and thought the experiment pointless..
"A nation that forgets its past is doomed to repeat it." - Churchill
So instead of "Not guilty by reason of insanity" they now might say "Not guilty because of genetic tendency"?
There will be no stupid people, unemployment or poor. Instead we'll have genetically indisposed, between jobs or financially challenged. Say anything else and the PC will hit you.
I find that the following two axioms explain much of what I observe in human behavior...
1: Thinking is hard.
2: People are lazy.
That's all here is to it.
Ian Ameline
I know a recovering alcoholic pretty well, and one of her pronounced traits is repeatedly doing the same things that she knows she shouldnt. Keep in mind that the phrase "Insanity is doing the same action over and over again and expecting a different result" comes from AA.
Oddly enough, it only became really pronounced AFTER she stopped drinking - gene activation?
"As God is my witness, I thought turkeys could fly." A. Carlson
Hey I know that girl too!
I would like to know if this gene is more common in males or females, and if it increases or decreases with aging.
The road called "genes" isn't the only one that can take you to Rome. There are plenty of others. If life was like a golf green, genes would be the contour and speed of the green. Learning, society and environment would be the skill of the golfer, the putter, the wind, etc.
Really, do I need to add anything here at all?
They keep finding genes for all kinds of "unwanted conditions", so one must draw the conclusion that the next step is to find a way to screen for these genes in embryos, or possibly prospective partners (I hate to sound too GATTACA here, but bear with me).
Now, i'm not one of those "genetics will destroy mankind" nutjobs, but there is one point i'm worried about.. if we start eliminating/changing genes that we don't want, are we perhaps eliminating things humanity needs in the future. Few examples:
-Autism is something people would probably like to eradicate, but on the other hand many brilliant people suffer from a mild form of autism.
-Where would Woody Allen be without his neurotism?
People are already stuffing their kids with Ritalin to control their behaviour and place it in an acceptable mold. But if you homogenize everything (whether through drugs, or in the future, altering genes), how can we progress? Instead of a pack of individuals, are we becoming a hive?
In techie terms: Is mankind selling it's chance to evolve into v2.0 in the future in exchange for a quick fixpack?
No wonder we get goatse.cx posts. Unless posting is not an unfavorable experience to it's authors.
(Word of caution: don't clink any links appearing in reply to this)
Hmmm. I wonder if there's a criminal aspect to this. Do repeat convicts in the US have less d2 receptors on average? People who have been arrested more than once and continue to commit petty crimes?
With a genetic disposition for typos and dupes, is like an airline pilot with a genetic disposition for running
into the ground.
Ars has a good writeup of the article in nature, for those who want to read more, but don't want to bother w/ the journal article.
why I keep coming back to Slashdot!
The more you regulate a company, the worse its products become.
-D2 troll
I think we can explain dupes from simply not having infinite memory, I mean really. Those with better memories = less mistakes, I would imagine.
It all makes cents now. It all makes cents now.
Intelligent design
...the Homer gene?
Mmmmm..... donuts.
Light a fire for a man and he'll be warm for a day. Light a man on fire and he'll be warm for the rest of his life.
Would this gene be something they could pay $999 to find out
oh, wait...
leads to a lessened ability to learn from experience
I prefer to think of that as the triumph of optimism over experience.
You can see the result from our repeatedly going to get a girl, getting stung by them (they run off with your money and your best friend) and then trying to find another (or the same) girl to get back with us.
If you don't have 2 missing genes, you must be gay off course. For most geeks it is unknown whether or not they are missing some genes.
Custom electronics and digital signage for your business: www.evcircuits.com
Isn't addiction the result of the brain learning too well that getting a certain stimulus triggers the pleasure/reward sensation? It's only a "mistake" when the stimulus turns out to be a false positive. The same "addicted" reaction to a drug that short-circuits the reward sensation might cause a person to acquire and maintain very good habits for needed nutrients or acquiring resources. It's a tradeoff between locking in behaviors that consistently produce rewards and the risk that you are locking in slowly self-destructive behaviors that only seemed to be a reward. A person who can break addictions easily may also tend to randomly stop doing useful, rewarding things.
Learning from experience is a very vague concept. I think that people DO learn something from each mistake they make, it's just there are lots of things to learn from one bad experience or failure.
:).
For instance, if you jump from the 5th floor and break a leg, you can learn that:
1. Jumping is bad
2. Jumping from a hight is bad
3. Courage is bad
4. I cannot judge heights
5. My body is too weak
6. Next time when I jump, I should be more careful
and so on, you get the idea.
There can be multiple interpretations of one experience so I guess it's better to say that people learn the wrong things from experience rather than 'they don't learn from experience'.
If you put it this way, the D2 gene explains something completely different.
In fact, people who don't learn from experience sometimes end up discovering new ways around limitations (eg. wright brothers), which is, after all, a good thing
I've read that the original idea behind India's caste system (a long, long time ago) was that different people were qualified for different jobs. I.e., ruling, manual labor, trade, etc. The idea was to basically codify this reality. (I don't believe that caste was originally imagined as hereditary, but I could be wrong.)
Anyway, if persons' ability to handle responsibility, make good decisions, etc. could be shown to have a genetic basis, I wonder if this would actually validate some of that old system's grounding principles.
(Also reminds me go Gattaca, though.)This probably explains why Bush keeps doing the same thing over and over expecting different results.
"You'll get nothing, and you'll like it!"
Dear Kansas City school board:
The "Creator" is apparently making some people "Unintelligent by Design!".
Perhaps this explains how the "Intelligent by Design" theory came about.
No wonder I keep forgeting to prevew my posts.
You'd think I'd learn butt nooooooo.....
YOUR KIDDING!
I don't want any of my kids to marry somebody with the defect.
That's not the only defect of interest. Full genetic testing
would be a good thing, at least for people who have fewer
defects than average. The below-average people just shouldn't
breed. If they get stuck breeding with each other, at least
the die-off rate will increase.
To oppose this is to say that either:
a. you don't believe in evolution
b. you're OK with humans evolving to be stupid creatures
that depend on modern medicine for survival, with the
collapse of our population if modern medicine should
happen to become unavailable from all the stupidity
if we start eliminating/changing genes that we don't want, are we perhaps eliminating things humanity needs in the future.
While I understand your point we have already been doing this to some extent for the past 100 years or so. As technology has improved people who would never have survived to reproductive age have managed to do so. A genetic weakness to measles, polio, TB etc is no longer a problem thanks to vaccines and infections are far less dangerous thanks to antibiotics so people with weaker immune systems are not disadvantaged.
So given this I'd propose a slightly provocative question: "Can we afford not to start manipulating our own genetic heritage?". I don't know the answer but I'd much rather have the knowledge and ability to do this than to not have it because who knows what nature will throw our way in the future?
Great! So the human genome now has a CowboyNeal option! ;-)
We have no privacy here, even when we should. We must waive HIPPA rights to get insurance, etc.
Imagine targeted advertizing. The casino industry won't have to waste advertizing on people like me. They can just target the people most vulnerable.
The article is not from Nature, but from Science...
There now sonny. Sleep tight - 200 years of experience of all of that shit - you really got it locked down. Do you have a hat ?
How many beans make five, anyhow ?
We've known this for a while, haven't we?
http://www.timecube.com/
To prevent this day from getting worse, I'll just read ERROR as GOOD TH
I'd have thought Sony would have a patent on this already...seems to be an integral part of their business.
Stasis is death. Embrace change.
Nope .... sorry
How many beans make five, anyhow ?
This explains my wife....
:D
and hence why i post AC
This is a good example of why employers using DNA in their screening process is wrong.
Going to end up with a world of 'unemployables' as DNA technology improves to a frightening point of accuracy.
---- Booth was a patriot ----
Drs. Klein and Ullsperger noted that upon discovery of the gene, they tested themselves for its presence.
"Fortunately we determined we were both negative for the A1-allele," Dr. Klein admitted with some relief, with Ullsperger adding, "We double checked just to make sure."
There are two kinds of people: 1) those who start arrays with one and 1) those who start them with zero.
We get tell the spelling/grammar nazis to go away. Anyway, it also sounds like there could have some relation to Alzheimer's. Of course I'm no geneticist, but it seems to me there would no single gene that control just one single function. Kinda like killing a butterfly in Australia will cause a hurricane in Florida. Too many unknowns. Fixing this gene might help your memory, but it might also make you grow three eyes on your butt. Now there's a lovely thought.
What?
You mean they finally found the slashdot gene? Does that mean they will cure all slashdot users? I see the end of slashdot rushing at us.
heh heh
wake up and hold your nose
Do you think that we could all chip in and get Taco some gene therapy to cure /. dupes?
Politics is the art of looking for trouble, finding it everywhere, diagnosing it incorrectly and applying the wrong fix.
"The researchers chose men because dopamine levels change during a woman's menstrual cycle, which would have complicated the study."
So...if a woman already had fewer D2 receptors, and her dopamine levels change naturally, then she'd be even more unable to learn from negative experiences. Doesn't that sound familiar?
If the gene makes you more likely to make typos then we need to be complaining about you *more*, not *less*, in the hope that nurture can overcome nature. And you should be thanking us for the privilege.
Doesn't it make you feel good to know that our freedoms are protected by politicans, lawyers and journalists.
There's no need to expect extraordinary idealism and then be surprised and despise them for being just like everybody. Expect them to be selfish and work with it.
I still wonder what you'd prefer instead
Bitching about politicians is patriotic and an American birthright. If Jesus Christ were President, we would bitch about him too, and he'd never make it over 50% in the polls unless He bombed someone.
We know our form of government is the best and our country is the best, but, if we don't keep bitching about it, or trying to improve ourselves, then, we'll wind up as yet another nation that lost its purpose. Democrat, Republican, Conservative, or Liberal, alike, are all trying to put forth ideas to improve our country. If they didn't, and didn't fight about it, then, wouldn't that defeat the whole purpose of Democracy?
This is my sig.
I'm doing my part to fix things. How about you?
We've pretty much run out of Flynn effect. IQ is predicted to drop a point or so each year based simply on who is having the kids. (IQ is not recentered, and thus not fixed at a mean of 100)
It won't keep up forever. It can't, because society can not be sustained with stupidity. Industry will eventually collapse. We're so interconnected these days that it will be a bit of a chain reaction.
In the coming disaster, survival will mean having all the old-style survival traits.
Look at the evolutionary pressure today. The big thing to overcome is birth control. It's unlikely that we will overcome birth control via body changes. Behavioral changes can do it though. The immediate effect is that stupid people are selected for. Long term though, it'll be people who just WANT lots of kids.
Isn't insanity often defined as repeating the same action and expecting a different result?
So it's a gene that causes me to meet women who seem very nice and are attractive until they convince me to move in with them and then they gain 20 pounds and turn into a bitch? At least that means there's hope. I was starting to think that's what they all do.
It would make more sense for you Americans to simply expect your politicians to be selfish like everybody, and not despise them for that, and instead despise your system if it doesn't provide suitable checks and balances. Which I think it doesn't
We despise our politicians, becuase, we can. We despise our system, because we can. We in America are always searching for better, in our goods and in ourselves and above all, in our leaders.
Our system provides for more checks and balances than any parliamentry system, simply by virtue of having the executive branch be genuinely separate from that of the legislative. Finally, as a practical matter, our system is the only system that exists genuinly by the consent of its governed. The vast majority of Americans own a gun of some kind, and to own a gun is to have -real- power, far more than even our mighty military has.
In every conceivable way, one can make the argument that the USA is the greatest country in the world. Taken as a whole, the American race is the genetic best from around the world, combined into one super citizenry body. But, despite that, we are not the type of people to sit by and think that we are happy. We have to do better, have to have more, and we will. And then, when we get sick of that, we'll bitch about that too.
Only losers are reasonable.
This is my sig.
You make it sound as if it's mildly astonishing that 2 children by the same parents could be so different. Genes trump all, right? Perhaps. One child at a delicate age could be exposed to environmental contaminants such as mercury, lead, funky sex hormone mimicking soft plastics, gasoline with lots and lots of additives, while the other isn't. Perhaps in another era that hyper child would have been a vigorous worker, but instead was screwed up by industrial poisons. The focus on genetics is certainly convenient for pollution generating industries that wish to avoid and divert attention away from inquiries into the effects of their activities. I recall reading an interesting report on the big power outage across the NE US some years ago. People's allergies miraculously cleared up those few days when the NE was without power. I have not been able to find that report again.
Intellectual Property is a monopolistic, selfish, and defective concept. It is "tyranny over the mind of man"
You lost me at could be shown. The whole point of the nature/nurture debate is that it can't be shown.
At the risk of firing an arrow so far over your head it passes into an alternate universe, this can be quite readily demonstrated from the vantage point of cryptographic theory. This page describes a hash function which fails to achieve uniform cryptographic avalanche.
http://home.comcast.net/~bretm/hash/6.html
What this means is that correlations remain between which input bit is modified and the distribution of the output bits. Consider that some of these input bits are nature, other input bits are nurture, and if you like, set aside some of the bits as hidden state variables for the subject concerned.
There are correlates for some restricted input subsets, but few general correlates over the full range. The human organism is complex enough that nature and nurture interleave into partial avalanche. Too many sub-correlations are exposed to make it much use as a cryptographic function, but all the same far too intricate to think it could ever be shown that genes and outcomes exist in any fixed relationship.
This conceptual fallacy was also debunked in the context of Laffer curves. Check out the Neo-Laffer curve. It also serves as a good illustration of the typical complexity of any gene determining any definable outcome.
http://en.wikipedia.org/wiki/Laffer_curve#The_Neo-Laffer_Curve
My cryptographic example merely shows that it is possible to draw a Laffer curve over multiple inputs and outputs with no correlation anywhere. Anyone here surprised that genetics can't be reduced to the smooth hump of a Reagan-era tax slogan?
Now, at some point some genes will be shown to have strong effects under broad conditions, but even then, not without a twenty page appendix of fine print covering assumptions and conditions. Conversely, many of our genes will prove to have such a baffling array of possible downstream effects, that soon the refrain from the peanut gallery will become "why do we bother, if nothing is ever proved?" Get used to it.
It can't be shown.
Hello, duh, this is the slashdot gene. It the gene that makes people post, repost, reply, and read when they already know no one is paying attention, no one understands, and no one cares, and no one has anything better to do.
You can't handle the truth.
Working very hard, merely means that someone didn't figure out a better way to do what it is they do.
Also, getting involved in governance reminds me of the old adage.
"Don't vote, it only encourages them!"
" What luck for rulers that men do not think" - Adolf Hitler
this is really great nuez. Now I no longer have to learn how to speil correctly. I can't speil because I have a bad gene.
Heinlein wrote about FASCISM in that book, but that must've slipped by you. We're talking about plain simple citizen militia as written INTO the second amendment. Not this watered down federalized arm of the military that we call the 1906 National Guard. If that was truly what the 2nd refers to, its also called EX POST FACTO LEGISLATION, and that's prohibited by the main body of the Constitution as well!
" What luck for rulers that men do not think" - Adolf Hitler
Then the government is too big if they need unelected (and thus not responsible to the electorate) employees.
This is the problem that has been around forever. Those employees owe their loyalty to those signing their checks, and those signing their checks are NOT the electorate... it is the rulers. The rulers redistribute the wealth they confiscate through taxation. Thus it is the RULERS who command the loyalty of the army and of the police arms. This has ALWAYS been the case, and the system has YET to change. This has been the case since the first thug band got big enough to call itself "ruler of all their leader could see"... and thus a "government".
" What luck for rulers that men do not think" - Adolf Hitler
it's the gene that makes some people not have any self-control and willpower.
A December 6th article in Nature explores the relationship between a specific gene and those of us prone to repeatedly making the same mistakes. From the article: "Drug addicts, alcoholics and compulsive gamblers are known to be more likely than other people to have this genetic mutationI don't call drug addicts, alcoholics, and gamblers people who make mistakes. I call them people who don't have any willpower to stop doing something that is bad despite what temporary "rewards" those things give people.
this nation, under God, shall have a new birth of freedom. -- Lincoln, Gettysburg Address
This knee-jerk reaction is incorrect. Generally speaking, correlation is not causation because the two correlated items might share a cause. In this case, one of them is the presence of a gene. What causes a gene to be present? All I can think of is "another gene" (that is, this might happen to be on the same chromosome as something that *actually* causes the repeated mistakes), in which case it's still the same story: this behavior is caused by a gene.
Science. 2007 Dec 7;318(5856):1642-5.
Genetically determined differences in learning from errors.
Klein TA, Neumann J, Reuter M, Hennig J, von Cramon DY, Ullsperger M.
http://tinyurl.com/2z5dzt
A lot of the examples given sound like a lack of will power to me; alcoholism, gambling, etc.
"He who can destroy a thing, controls a thing." --Paul Atreides, Dune
Since LSD upregulates D2 maybe those accounts of LSD helping alcoholics, drug addicts, gamblers, etc. could base some research off this study.
I recently caught wind of some young people tossing about the idea of selling a vote on ebay. (!?)
The trick is: It's a method of pre-planning the vote without it being the blind activity we have today. In extreme circumstances it might be enough to haul in a dark horse third party, but only with a devastating candidate, which isn't present in this election.
Tom Clancy once wrote a book whereupon a character had to remake the government, and he nixed "all the bums". Already, we're discussing the First Woman and the First African-American in a serious run for President. Those are both non-tradtional candidates, but I don't know if we're ready for that at the gut level, despite our griping.
My first Journal Entry ever, in 8 years! http://slashdot.org/journal/365947/aphelion-scifi-fantasy-horror-poetry-webzine
"Can't blame me for making the same mistake repeatedly! It's genetic!"
Yeah, but you still make the same mistake repeatedly, so, I'm going to judge you because of it.
"But I can't help it!"
Isn't that more of a reason to hold it against you, not less of one?
"Can't blame me for being ugly, it's genetic!" you're still ugly
"Can't blame me for being a jerk, it's genetic!" you're still a jerk
"Can't blame me for being smart, it's genetic!" you're still smart
If you want to use the "it's genetic" argument, doesn't it imply an acceptance of our deep-rooted need to judge people and find either favor is disfavor about them because of their genetics? You may have redeeming qualities; but, if you repeatedly make the same mistake, not repeatedly making the same mistake isn't one of them. It's still a character flaw. Being a character flaw that is encoded into the most basic parts of every atomic unit of you that can still be considered "you" doesn't make it any less of a flaw.
So I'm still going to complain about tacking "funny" little misleading quips to the end of article summaries, no matter how many times you do it, no matter why you do it.
And I'll do so repeatedly.
-- 'The' Lord and Master Bitman On High, Master Of All
So have they found the gene that explains the need to find genes that explain human characteristics?
I am anarch of all I survey.
Oh ya mean the gene most expressed by officials in our present Administration. Just cannot learn that torture is evil, that Iraq had no weapons of mess disillusion, and that Iran is trying to do what its religion, Shia'ism ,says is immoral. Shia's would never willingly develope nuclear weapons for to use them would be to commit murder of innocent people, 'harram'(forbidden) in Shia Islam. What is going to be really funny is when a future Democratic administration refuses to pardon Bush/Cheney/Rumsfeld/Gates/Bolton and the rest of that gang for crimes against humanity, murder, mass murder, torture, and the rest of the most foul evils men have ever commited against humanity and equivalent to the worst evils of Adolf Hitler and Pol Pot and Kemal Ataturk and others. What will be even better is when these victims show up in American courts to sue these gangsters in our present administration, or even better, try to charge them with international war crimes before the United Nations. Can you just see, Cheney for instance, in the same cell with Milosevic or Mladic or Pol Pot.....or would that be an 'undisclosed location'. Any more, present administration members will start to have the hunted look that the German Waffen SS guards did in the closing days of the Great Democratic War (WWII in the West).
Is smoking irrational? Say new cigarettes become popular that are only half as harmful as they are today. Is it still irrational to smoke them? How about 1/8 as harmful? 1/16? What if smoking over the course of your life merely cost you on average one month at the end, and three months of degraded standard of living?
Any time you make the statement that an individual is behaving "irrationally", pay attention to the assumptions that you're making about utility functions, and which set of values and priorities is "best".
<-- 1-way (no replies)
The two (learning and willpower) are remarkably related, especially when it comes to shortages/surpluses of dopamine. Try amphetamine or cocaine some time, and be amazed at just how neurochemically quantifiable willpower is.
Bruce Lipton has a very enlightening view and explanation on DNA and its many myths exposed:
1) DNA is much more varied in one body than popular science will have us believe.
2) DNA is not decoded just one way, but in real-world situations, signals alter proteins covering different parts of the DNA, which alters how DNA is expressed.
3) How we use our mind and body then releases different hormonal signals, which discover different potentialities in our DNA.
4) The ancient knowledge of "you are what you think you are", is actually now indicated by scientific tests on DNA and how hormons affects it. Your feelings and belief-system will actually change your DNA expression!
5) His conclusion in Part 2 is very empowering and telling for most of us.
Well worth the watch:
Part 1: http://video.google.com/videoplay?docid=-8506668136396723343
Part 2: http://video.google.com/videoplay?docid=-6568107389365915765
http://www.debunkingskeptics.com/
You don't understand. Hillary may be an unusual candidate, but she's been bought. I'm not certain about Obama, but I very very strongly suspect so. (He's already in congress, after all.)
A reform would require something like instant runoff or condorcet(sp?) voting. Condorcet is the better of the two choices, but instant runoff isn't that bad. Both give voters the chance to vote for a ranking order of preferences on their ballot. Then the ranking orders are compared with multiple steps of elimination of the least desireable candidate until a single candidate gets more than 50% of the remaining vote. (They differ in the precise order of candidate eliminations.)
This means that if you would really prefer a Vegetarian, next the Libertarian candidate, and after that the Democrat, then Republican, then Fascist you can vote in that order without losing your vote. This would make it much more expensive to buy an election by buying all of the candidates, however indirectly. It would become more cost-effective for corporations to campaign for policies rather than for specific candidates.
Another change that needs to be made is that the corporations controlling "the public airwaves" need to be forced to provide a certain amount of free access to every candidate. This used to be the rule before the FCC sold out. (Actually, I believe the rule was "equal access", so that if one candidate bought some time, the other candidates. This has it's points, but if many candidates are running, then it might wipe out all media campaigning, by making airtime too expensive, unless a certain amount were mandated.)
Also, now that billboards, newspapers, etc. are monopolies, those should fall under the same kind of regulation that I'm proposing for the airwaves. Exceptions should require that any particular corporation for a particular mode of media (say billboards) should be required to prove that it owns or controls less than 50% of the penetration in it's area of service.
I think we've pushed this "anyone can grow up to be president" thing too far.
What is this doing on the front page of slashdot?
> The reason "stupid" people reproduce so much
and look where that got us:-(
how to blame anything on the genes.