IAAB (or at least just majored in it last year...hello job market). Translated into plain english, the first part says whats already been repeated several times, that some human cancer types exhibit hyperpolarized mitochondrial membrane potentials, and low expression of the membrane protein that facilitates potassium transport across the membrane. This results in a low permeability of the membrane to proteins. Several apoptitic pathways rely on various proteins being taken up by the mitochondria, which then releases several other proteins back into the cytosol. These cancer cells would then become resistant to induced apoptosis via these mechanisms.
DCA seems to lower the mitochondrial membrane potential and activate mitochondrial potassium channels by blocking a kinase (a protein that adds a phosphate group) whose target is responsible for the formation of AcetylCoA, the first step of oxidative metabolism, which then "normalizes" mitochondrial function. Importantly, the researchers have tested their experimental result by using siRNA, (small interfering RNA) to block the action of the kinase whose target is the original pyruvate dehydrogenase kinase (thus the PDK2, the 2 being the same as a PDKK). siRNA confirmaion is a strong indicator that the pathway they are targeting is working and having the effect desired by the drug.
Living things have evolved (Oh noes!11!! the E word!) many defenses against runaway cell growth, and in healthy cells, they go into action during cell division. If the cell fails to meet various criteria, it undergoes apoptosis, and basically commits suicide. Unfortunately, Cancer is a symptom of the breakdown of several of these defenses (usually via mutations in both the various tumor suppressor genes, rendering them ineffective, as well as over expression of proto-onco genes) that results in a cell with nothing to stop its runaway cell division. This cell rapidly reproduces, often resulting in further mututations and et Voila!
Cancer is what we call the result.
Cancer isn't really a disease in the conventional sense, but more a symptom of a breakdown in the natural regulation measures of a cell.
Is that the stencil is actually a fourier transform hologram, printed out on film. This would look like a pattern of seemingly random dots, but a focused beam of light would resolve the hologram image, even if sent photon by photon over time on a detector.
That would be a good idea. However, every so often (1 in 100? 1 in 50?) a rocket launch doesn't go right...a self desctruct option on a rocket carrying payload of nuclear waste isn't a very good idea, neither is letting a rocket that won't make escape velocity burn out...that leaves engineering black-box type of containers to contain the waste (which is already pretty damned heavy), causing your launch weight to go up, necessitating bigger more complex rockets...(and back to the beginning agan)
Stop thinking of photons as particles. There are times and places where it's convenient and simple to think of them as such, but quantum entanglement isn't really one of them. To make any sense of it, you need to consider each as an entangled wave function. Unobserved, you can have each particle take any arbitrary number of paths through space time, which allows for interference patterns and fringes. Once you observe one part of the entangled wave function, you have collapsed BOTH of them, resulting in a particular outcome for the entangled photons.
Yes, they announced that it had GPS. And while it wasn't explicitly stated, can you really imagine any possibility of it NOT "knowing" where it is when you fire up google earth on it?
Wikipedia says it was estimated at a few petabytes back in '03, but now their cluster has that much RAM (!!!), so even at google, they could probably use several hundred of these.
Not really, and not for a particularly worrisome period of time. Sure, you get above the ozone layer but seeing as you're in an enclosed capsule (with UV blocking glass windows) UV radiation isn't going to matter. Neither are the harder X-rays, for much the same reason. Cosmic rays and particle radiation you might encounter are unlikely to be noticably increased either, as you're still well within the earths magnetic field. Gamma rays are your only real concern, and with a hour duration flight to the other side of the planet, you can figure at least part of that time the earth is going to be between you and the sun, it's really an awful lot less exposure than say, a member of the ISS crew recieves each day.
Both articles repeat the phrase "uses lasers to compact large amounts of information onto a DVD" and then state that several layers would then be utilized. First of all, what the hell does using lasers to compact information mean? As far as I can tell, the articles explain how they are able to cause a state change in recording media with two wavelengths of light, and read it using a single wavelength, and that this media layer is particularly thin, allowing for multiple layers to be stacked up on the disc.
In my opinion, if you're going to the trouble of utilizing a multiple beam system in your drive, holographic storage makes a lot more sense, as both beams are the same wavelength (meaning only a single laser and a beam splitter are needed), your read times are going to be tremendously faster, due to the data all being stored in the same layer, obviating the need to refocus or switch beams, and finally, due to the nature of holography (in that small sections of a hologram contain the information needed to reconstruct the entire hologram), a disc with holographic storage should be much more resistant to read errors resulting from scratches, whereas with one of these, a scratch could render data on several layers unreadable.
They were referring to the short lived DivX Disc format, which was like a rental in that you paid a few bucks for the disc, but your player would connect to the internet and only allow you to watch it for a specified period of time.
South Pacific islanders that practiced cannabalism used to refer to human meat as "Long Pig" around westerners so as not to clue them in, and furthermore, those same peoples became avid consumers of SPAM, which they claim tasted pretty darn close to people.
Wouldn't this be really easy to prove, I would have thought that if this was the case it would make the moon notably hotter than the ambient temperature of space, so could they not just stick an infra-red camera at it and look to see if there is a difference?
I know I'm missing something but I'm not sure what...
Well, first of all, the ambient temperature of space is in the microwave region of the spectrum, not IR. Second, the moon absorbs an awful lot of light from the sun (there is no true "dark side" of the moon, although we dont see it, it certainly has day and night periods like any other rotating celestial body), which is then radiated away through the lunar night until the next lunar sunrise.
Wrong. All the plutonium bombs the US has built have been implosion devices. However, any fissile material of high enough enrichment can be made into the simple shotgun type bomb of the design of the bomb dropped on Hiroshima (although that one used uranium as fuel). The scary thing about this type of bomb is that while the yield is much lower, they are quite simple to build in comparison, and if one uses P239 as the fuel source, a very highly enriched fuel mass needs only to be about the size of a grapefruit.
He certainly didn't tell us when I had him a few years back (And Chad, if you're reading this, (1) You still owe me and Matt a round of beers and a game of beer pong, and (2), Now do you know why talking like a pirate came so easily to most of the class?). Anyway, while its interesting that he's taken the time to raise this point, stating that bloggers are dumber than high school kids is like stating third graders have difficulty with lorentz transformations. Not to mention the fact that a good deal of the time, high schoolers (and middle schoolers!) are bloggers.
Slashdot Mirror
the downside is a bit of quality lost in the conversion, remember, we're talking lossy formats here.
IAAB (or at least just majored in it last year...hello job market). Translated into plain english, the first part says whats already been repeated several times, that some human cancer types exhibit hyperpolarized mitochondrial membrane potentials, and low expression of the membrane protein that facilitates potassium transport across the membrane. This results in a low permeability of the membrane to proteins. Several apoptitic pathways rely on various proteins being taken up by the mitochondria, which then releases several other proteins back into the cytosol. These cancer cells would then become resistant to induced apoptosis via these mechanisms. DCA seems to lower the mitochondrial membrane potential and activate mitochondrial potassium channels by blocking a kinase (a protein that adds a phosphate group) whose target is responsible for the formation of AcetylCoA, the first step of oxidative metabolism, which then "normalizes" mitochondrial function. Importantly, the researchers have tested their experimental result by using siRNA, (small interfering RNA) to block the action of the kinase whose target is the original pyruvate dehydrogenase kinase (thus the PDK2, the 2 being the same as a PDKK). siRNA confirmaion is a strong indicator that the pathway they are targeting is working and having the effect desired by the drug.
Living things have evolved (Oh noes!11!! the E word!) many defenses against runaway cell growth, and in healthy cells, they go into action during cell division. If the cell fails to meet various criteria, it undergoes apoptosis, and basically commits suicide. Unfortunately, Cancer is a symptom of the breakdown of several of these defenses (usually via mutations in both the various tumor suppressor genes, rendering them ineffective, as well as over expression of proto-onco genes) that results in a cell with nothing to stop its runaway cell division. This cell rapidly reproduces, often resulting in further mututations and et Voila!
Cancer is what we call the result.
Cancer isn't really a disease in the conventional sense, but more a symptom of a breakdown in the natural regulation measures of a cell.
In Soviet Russia, outdated TLDs delete you!
Where can I sign up for that?
Is that the stencil is actually a fourier transform hologram, printed out on film. This would look like a pattern of seemingly random dots, but a focused beam of light would resolve the hologram image, even if sent photon by photon over time on a detector.
That would be a good idea. However, every so often (1 in 100? 1 in 50?) a rocket launch doesn't go right...a self desctruct option on a rocket carrying payload of nuclear waste isn't a very good idea, neither is letting a rocket that won't make escape velocity burn out...that leaves engineering black-box type of containers to contain the waste (which is already pretty damned heavy), causing your launch weight to go up, necessitating bigger more complex rockets...(and back to the beginning agan)
Stop thinking of photons as particles. There are times and places where it's convenient and simple to think of them as such, but quantum entanglement isn't really one of them. To make any sense of it, you need to consider each as an entangled wave function. Unobserved, you can have each particle take any arbitrary number of paths through space time, which allows for interference patterns and fringes. Once you observe one part of the entangled wave function, you have collapsed BOTH of them, resulting in a particular outcome for the entangled photons.
Yes, they announced that it had GPS. And while it wasn't explicitly stated, can you really imagine any possibility of it NOT "knowing" where it is when you fire up google earth on it?
http://en.wikipedia.org/wiki/Petabyte
Wikipedia says it was estimated at a few petabytes back in '03, but now their cluster has that much RAM (!!!), so even at google, they could probably use several hundred of these.
In its own tests, ....
The lesson here is take any company's product description (especially before its released) with a grain of salt.
Not really, and not for a particularly worrisome period of time. Sure, you get above the ozone layer but seeing as you're in an enclosed capsule (with UV blocking glass windows) UV radiation isn't going to matter. Neither are the harder X-rays, for much the same reason. Cosmic rays and particle radiation you might encounter are unlikely to be noticably increased either, as you're still well within the earths magnetic field. Gamma rays are your only real concern, and with a hour duration flight to the other side of the planet, you can figure at least part of that time the earth is going to be between you and the sun, it's really an awful lot less exposure than say, a member of the ISS crew recieves each day.
Both articles repeat the phrase "uses lasers to compact large amounts of information onto a DVD" and then state that several layers would then be utilized. First of all, what the hell does using lasers to compact information mean? As far as I can tell, the articles explain how they are able to cause a state change in recording media with two wavelengths of light, and read it using a single wavelength, and that this media layer is particularly thin, allowing for multiple layers to be stacked up on the disc.
In my opinion, if you're going to the trouble of utilizing a multiple beam system in your drive, holographic storage makes a lot more sense, as both beams are the same wavelength (meaning only a single laser and a beam splitter are needed), your read times are going to be tremendously faster, due to the data all being stored in the same layer, obviating the need to refocus or switch beams, and finally, due to the nature of holography (in that small sections of a hologram contain the information needed to reconstruct the entire hologram), a disc with holographic storage should be much more resistant to read errors resulting from scratches, whereas with one of these, a scratch could render data on several layers unreadable.
You can borrow Audio CDs and DVDs from most libraries too!
They were referring to the short lived DivX Disc format, which was like a rental in that you paid a few bucks for the disc, but your player would connect to the internet and only allow you to watch it for a specified period of time.
Tubes?
thats 10.3k in USD.
South Pacific islanders that practiced cannabalism used to refer to human meat as "Long Pig" around westerners so as not to clue them in, and furthermore, those same peoples became avid consumers of SPAM, which they claim tasted pretty darn close to people.
Wouldn't this be really easy to prove, I would have thought that if this was the case it would make the moon notably hotter than the ambient temperature of space, so could they not just stick an infra-red camera at it and look to see if there is a difference? I know I'm missing something but I'm not sure what... Well, first of all, the ambient temperature of space is in the microwave region of the spectrum, not IR. Second, the moon absorbs an awful lot of light from the sun (there is no true "dark side" of the moon, although we dont see it, it certainly has day and night periods like any other rotating celestial body), which is then radiated away through the lunar night until the next lunar sunrise.
"involuntary personal protein spill" sounds like something that would fall under "public lewdness" or "indecent exposure"
The SNES was 200 when it first came out. http://en.wikipedia.org/wiki/SNES
Are you kidding, did you skip the above article, or are you the "expert witness" hired by the defendant?
Webmail that is accessed via a web browser is not something thats going to be cached, so what the heck are you saying?
Total recall took place on earth (briefly) and mars. They never even mentioned the moon.
Wrong. All the plutonium bombs the US has built have been implosion devices. However, any fissile material of high enough enrichment can be made into the simple shotgun type bomb of the design of the bomb dropped on Hiroshima (although that one used uranium as fuel). The scary thing about this type of bomb is that while the yield is much lower, they are quite simple to build in comparison, and if one uses P239 as the fuel source, a very highly enriched fuel mass needs only to be about the size of a grapefruit.
He certainly didn't tell us when I had him a few years back (And Chad, if you're reading this, (1) You still owe me and Matt a round of beers and a game of beer pong, and (2), Now do you know why talking like a pirate came so easily to most of the class?). Anyway, while its interesting that he's taken the time to raise this point, stating that bloggers are dumber than high school kids is like stating third graders have difficulty with lorentz transformations. Not to mention the fact that a good deal of the time, high schoolers (and middle schoolers!) are bloggers.