Domain: doi.org
Stories and comments across the archive that link to doi.org.
Comments · 315
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Alternate Coverage
Ars has better coverage which talks more about the polymers used and how this is actually achieved. It also has a link to the paper published in Nature (although you can only get an abstract if you're like me and don't have a subscription).
I submitted this story, too. So knowing Slashdot, we might see a dupe :-) -
Re:Is this really useful?
CO + H2O => CO2 + H2 is the common water-gas shift which is spontaneous (thermodynamically) below 800C. Used in coal-to-liquids after gasifying coal to make H2, and in H2 production from natural gas (CH4 + H2O => CO + 3 H2 and then make more hydrogen with CO + H2O => CO2 + H2).
CO2 + H2 => CO + H2O is the reverse water-gas shift which requires high temperatures and/or membranes for product separation to make it work. It is more difficult.
Combining CO2 with H2 is the most common method people have been discussing to produce fuels, since the 1970s using nuclear power, flue gas CO2 and hydrogen produced by electrolysis (look up Meyer Steinberg, I believe). CO2 + H2 can be reacted across a catalyst to make methanol without needing the reverse water-gas shift (3H2 + CO2 => CH3OH + H2O); it is a variation of traditional methanol production from CO + H2 (which typically has a little CO2 in there as well).
My other post for this article discusses the purpose behind such a fuel synthesis process more. -
Re:Scientists Trap a RainbowFirst off, for those interested (and with subscriptions) let me provide a reference to the actual paper (from last week's Nature):
Kosmas L. Tsakmakidis, Allan D. Boardman & Ortwin Hess 'Trapped rainbow' storage of light in metamaterials Nature 450, 397-401 (15 November 2007) | doi: 10.1038/nature06285. (See also summary comment box, doi 10.1038/450330a.) They propose a method that might. The meta-materials needed to do this with visible light don't exist yet. Your caution is quite correct. The paper is theoretical. An actual device has not yet been built. However this result is still significant because what they are showing is that the various results on "slow light" and "trapped light" can be realized in optical metamaterials. This is significant because metamaterials are in principle more amenable to technological deployment than the more exotic techniques of slowing light (ultra-cold condensates, etc.).
It's also worth noting that metamaterials at various wavelengths (e.g. microwave band and IR) have already been made. We are getting very close to optical metamaterials. For instance, see this review of the field:
Vladimir M. Shalaev Optical negative-index metamaterials Nature Photonics 1, 41 - 48 (2006) doi: 10.1038/nphoton.2006.49.
We already have prototype metamaterials at wavelengths of 780 nm, which is on the edge of the visible spectrum. Significantly, we already have metamaterials that operate in the IR band, which is what is used for modern fiber-optics, telecommunications, etc. The materials to date are not optimized, so it will of course be awhile before all these great applications of metamaterials are implemented in real telecom devices. But, still, we are getting quite close to these applications. In particular, I expect we'll see a commercial 'rainbow trapping' device for communications before we see a commercial 'invisibility cloak'! -
Re:Scientists Trap a RainbowFirst off, for those interested (and with subscriptions) let me provide a reference to the actual paper (from last week's Nature):
Kosmas L. Tsakmakidis, Allan D. Boardman & Ortwin Hess 'Trapped rainbow' storage of light in metamaterials Nature 450, 397-401 (15 November 2007) | doi: 10.1038/nature06285. (See also summary comment box, doi 10.1038/450330a.) They propose a method that might. The meta-materials needed to do this with visible light don't exist yet. Your caution is quite correct. The paper is theoretical. An actual device has not yet been built. However this result is still significant because what they are showing is that the various results on "slow light" and "trapped light" can be realized in optical metamaterials. This is significant because metamaterials are in principle more amenable to technological deployment than the more exotic techniques of slowing light (ultra-cold condensates, etc.).
It's also worth noting that metamaterials at various wavelengths (e.g. microwave band and IR) have already been made. We are getting very close to optical metamaterials. For instance, see this review of the field:
Vladimir M. Shalaev Optical negative-index metamaterials Nature Photonics 1, 41 - 48 (2006) doi: 10.1038/nphoton.2006.49.
We already have prototype metamaterials at wavelengths of 780 nm, which is on the edge of the visible spectrum. Significantly, we already have metamaterials that operate in the IR band, which is what is used for modern fiber-optics, telecommunications, etc. The materials to date are not optimized, so it will of course be awhile before all these great applications of metamaterials are implemented in real telecom devices. But, still, we are getting quite close to these applications. In particular, I expect we'll see a commercial 'rainbow trapping' device for communications before we see a commercial 'invisibility cloak'! -
Re:Scientists Trap a RainbowFirst off, for those interested (and with subscriptions) let me provide a reference to the actual paper (from last week's Nature):
Kosmas L. Tsakmakidis, Allan D. Boardman & Ortwin Hess 'Trapped rainbow' storage of light in metamaterials Nature 450, 397-401 (15 November 2007) | doi: 10.1038/nature06285. (See also summary comment box, doi 10.1038/450330a.) They propose a method that might. The meta-materials needed to do this with visible light don't exist yet. Your caution is quite correct. The paper is theoretical. An actual device has not yet been built. However this result is still significant because what they are showing is that the various results on "slow light" and "trapped light" can be realized in optical metamaterials. This is significant because metamaterials are in principle more amenable to technological deployment than the more exotic techniques of slowing light (ultra-cold condensates, etc.).
It's also worth noting that metamaterials at various wavelengths (e.g. microwave band and IR) have already been made. We are getting very close to optical metamaterials. For instance, see this review of the field:
Vladimir M. Shalaev Optical negative-index metamaterials Nature Photonics 1, 41 - 48 (2006) doi: 10.1038/nphoton.2006.49.
We already have prototype metamaterials at wavelengths of 780 nm, which is on the edge of the visible spectrum. Significantly, we already have metamaterials that operate in the IR band, which is what is used for modern fiber-optics, telecommunications, etc. The materials to date are not optimized, so it will of course be awhile before all these great applications of metamaterials are implemented in real telecom devices. But, still, we are getting quite close to these applications. In particular, I expect we'll see a commercial 'rainbow trapping' device for communications before we see a commercial 'invisibility cloak'! -
Re:Is fission not considered "burning fuel"?"burn" is synonymous with "combustion" or a chemical reaction in which heat and gas is given off. Nuclear fission is definitely not a chemical reaction, but a nuclear reaction. It is not in any way the same as "burning fuel." It uses a fuel, and creates some products, but it is not a chemical reaction. Thus, the author actually used very exact language, you just need a better vocabulary. I disagree. Read my post again and look up the meaning of the words "clean" and "metaphorically". My beef was with the juxtaposition of inexact language with exact language. You can burn things 100% cleanly, you can burn dirty magazines, and you can burn your ass on a metaphor. Technically no source of energy is inexhaustible. When fuel consumption is no longer economically viable, we will move on to other modes of energy production (solar power seems reasonable enough). What's so bad about using fuel that is plentiful and available to us if it is cheaper and easier than building solar panels and geothermal plants everywhere? Mining alone generally produces enough environmental degradation that we shouldn't do it unless there's a cost imposed on the mine owners to compensate the rest of the planet for the pollution. Once you get to burning the fuel, where your car sends carcinogens into my children's lungs with no compensatory penalty to you (my grandfather and uncle died of lung cancer, pretty horribly and at great expense) your economic argument completely falls apart. You aren't controlling for externalities like public health or crime. It's unnecessary and, frankly, idiotic to arbitrarily decide that we shouldn't use nuclear power simply because it has a finite fuel source. That's one of the very same fallacies that prevents people from embracing nuclear fusion. Again, I disagree. I certainly may be an idiot, but you are shortsighted and my argument is not arbitrary. You are settling for the good instead of reaching for the best in every part of your argument.
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Original Journal Articles
The original journal articles for those interested in more than a press release:
Efficient Oxygen Reduction Fuel Cell Electrocatalysis on Voltammetrically Dealloyed Pt-Cu-Co Nanoparticles (Strasser et al., Angewandte Chemie International Edition)
http://dx.doi.org/10.1002/anie.200703331
Electrocatalysis on Bimetallic Surfaces: Modifying Catalytic Reactivity for Oxygen Reduction by Voltammetric Surface Dealloying (Koh & Strasser)
http://dx.doi.org/10.1021/ja0742784
To fully answer that question would take a whole course on organometallic chemistry to explain, but it has to do with the d-electron configuration of the platinum, (d8), which results in organometallic compounds which can be either square planar or octahedral. The ability to switch between these structures (and related oxidation states) allows for transitions and bonding between the states which allows for the creation of intermediates necessary for catalytic reactions. Bulk platinum (i.e. as a heterogeneous catalyst) also has d-electrons available at the metal surface which can form bonding and anti-bonding ( = bond breaking) bonds with small molecules. Essentially when it is reacting with, say, hydrogen gas, the H2 adsorbs onto the surface and, each atom forming a bond with one Pt atom's d-orbital.
A good book might be Heterogeneous Catalysts for the Synthetic Chemist (Google Book Search) -
Original Journal Articles
The original journal articles for those interested in more than a press release:
Efficient Oxygen Reduction Fuel Cell Electrocatalysis on Voltammetrically Dealloyed Pt-Cu-Co Nanoparticles (Strasser et al., Angewandte Chemie International Edition)
http://dx.doi.org/10.1002/anie.200703331
Electrocatalysis on Bimetallic Surfaces: Modifying Catalytic Reactivity for Oxygen Reduction by Voltammetric Surface Dealloying (Koh & Strasser)
http://dx.doi.org/10.1021/ja0742784
To fully answer that question would take a whole course on organometallic chemistry to explain, but it has to do with the d-electron configuration of the platinum, (d8), which results in organometallic compounds which can be either square planar or octahedral. The ability to switch between these structures (and related oxidation states) allows for transitions and bonding between the states which allows for the creation of intermediates necessary for catalytic reactions. Bulk platinum (i.e. as a heterogeneous catalyst) also has d-electrons available at the metal surface which can form bonding and anti-bonding ( = bond breaking) bonds with small molecules. Essentially when it is reacting with, say, hydrogen gas, the H2 adsorbs onto the surface and, each atom forming a bond with one Pt atom's d-orbital.
A good book might be Heterogeneous Catalysts for the Synthetic Chemist (Google Book Search) -
Re:Brain implants?We know from dreams that the brain can process things quicker where our sense of time passing is not "real time" (ie, a dream that seems to go on for 30 minutes might take place in a MUCH shorter ammount of real time). Actually that is more folklore than fact. Here's a modern review of research in dreaming:
Alan S. Eiser "Physiology and Psychology of Dreams" Seminars in Neurology, vol. 25, No. 1, 2005. doi: 10.1055/s-2005-867078
According to that article:There is evidence the dream is coextensive with the REM period and that the time length of dreams, as subjectively experienced by the dreamer and objectively rated by experimenters, is closely related to the real-time length of the corresponding REM period.
Actually this was established early on in the research on dreaming. See this article from 1957:
Dement W, Kleitman N. "The relation of eye movements during sleep to dream activity: an objective method for the study of dreaming." J Exp Psychol 1957;53:339-346
The idea that dreams are somehow accelerated with respect to normal time isn't substantiated. Yet for some reason it has taken root in pop science. As far as I know, the notion that the human mind can process information/sensations faster than real-time has not been established. -
Their performance report on-line ...
If you have 30 USD, you can read their full performance report. Without paying, even the abstract might tell you something.
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Re:Strong as Steel?If you're interested in the details (and have a subscription to Science), here's the actual paper:
Paul Podsiadlo, Amit K. Kaushik, Ellen M. Arruda, Anthony M. Waas, Bong Sup Shim, Jiadi Xu, Himabindu Nandivada, Benjamin G. Pumplin, Joerg Lahann, Ayyalusamy Ramamoorthy, and Nicholas A. Kotov "Ultrastrong and Stiff Layered Polymer Nanocomposites" Science 5 October 2007: 80-83. DOI: 10.1126/science.1143176.
Blurb:Deposition of alternating nanoscale layers of clay particles and a polymer yields a transparent composite that is as stiff and strong as steel.
The abstract is:Nanoscale building blocks are individually exceptionally strong because they are close to ideal, defect-free materials. It is, however, difficult to retain the ideal properties in macroscale composites. Bottom-up assembly of a clay/polymer nanocomposite allowed for the preparation of a homogeneous, optically transparent material with planar orientation of the alumosilicate nanosheets. The stiffness and tensile strength of these multilayer composites are one order of magnitude greater than those of analogous nanocomposites at a processing temperature that is much lower than those of ceramic or polymer materials with similar characteristics. A high level of ordering of the nanoscale building blocks, combined with dense covalent and hydrogen bonding and stiffening of the polymer chains, leads to highly effective load transfer between nanosheets and the polymer.
In response to your questions about actual material response, the paper discusses a variety of metrics for a variety of different preparation conditions. They report that the nano-composite material has an ultimate tensile strength 10 times greater than the pure PVA polymer, up to 480 MPa. They also state that the modulus, E, was 100 times greater than the pure polymer, up to 125 GPa, which they compare to Kevlar (E ~ 80 to 220 GPa).
In terms of energy absorption, they compare the uncrosslinked nano-composite to the crosslinked one. As you might imagine, the crosslinked one was more rigid (and gave rise to the modulus previously mentioned), having a low ultimate strain of 0.33 %. The uncrosslinked one deformed somewhat more (ultimate strain 0.7%), with higher energy absorption potential.
As you note, the comparison of "strong as steel" is not very helpful. But looking at the stress-strain curves, these materials look quite strong. Also, since you can adjust the material properties (optimizing for energy storage versus elastic modulus), they might be great for achieving desired performance for certain niche applications. -
the actual reference...
Yet another scientific story with big claims and little detail. 2nM accuracy sounds a little overstated.
Indeed. The news release misses the point of the paper somewhat.
The actual scientific paper appears to be this one:
Phillip W. Snyder, Matthew S. Johannes, Briana N. Vogen, Robert L. Clark, and Eric J. Toone, "Biocatalytic Microcontact Printing" J. Org. Chem., 72 (19), 7459 -7461, 2007 DOI: 10.1021/jo0711541
Second they are using fluorescence to see the pattern and this at the very best has resolution of about 300nM.
They use confocal fluorescence which is, as you note, diffraction limited. However for the high-resolution study of the line-edges, they use Atomic Force Microscopy which is of course much higher resolution. The AFM images they show, however, appear to have rather imperfect line-edges, with resolution of >200 nm. Actually, nowhere in the paper do they claim to have demonstrated 2 nm resolution. Rather, they point out in the introduction that their new technique, in principle, could allow higher-resolution printing that conventional soft lithography, because there is no diffusion of reagents in their technique. The news release focuses on this mention of a theoretical 2 nm resolution, rather than pointing out the actual accomplishment of the paper, which in the words of the authors is:In conclusion, we have demonstrated the feasibility of biocatalytic lithography. Catalyst-mediated soft lithographic technique offers the advantage of lateral resolution controlled by the range of motion of the immobilized catalyst rather than by the diffusive properties of molecular inks. This feature should facilitate the implementation of strategies for stamping nanoscale features. Further examination of stamping parameters and the application of this methodology to nanolithography are underway, and we will report our results in due course.
So, in short, it's an important advancement but the authors are not claiming to have achieved the intended ultra-high-resolution yet. And, even without that optimistic resolution, the technique is interesting in its own right because it is a new way to control the nanoscale chemical patterning of surfaces. -
Re:Does...
The only thing that it says about the band is that none of their fans have taken game theory.
FWIW, game theory is a major part of my PhD (specifically social dilemmas), and I've just paid 5 pounds for the album. Usually I download music illegally and only buy CDs from my friends' bands, but I'm prepared to spend 5 pounds to reward the generous gesture of offering me the album for nothing.Your mistake is to assume that standard game theoretic notions of "rationality" apply to human beings. There's ample evidence to the contrary.
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Re:Missing the Point
The point is to reduce the overall cost of being capable of running the test, not in vastly increasing the efficiency of running a massive batch of tests this way. Certainly there's downstream potential for it...
Actually there is already research being done in that regard. Some research groups are experimenting with building microfluidic systems on compact-disks. The spinning of the disk generates a centrifugal force that acts as the 'pump' for the device, driving fluid through stages. You can even have special valves in your device, and by changing the rotation speed of the drive, you progressively move the fluid from stage to stage.
Then the CD laser can be used as a detection mechanism at different locations along the disk. Also you can obviously run multiple experiments at once, since as the disk spins the laser passes from one fluid channel to the next.
It's a rather cool idea to use commodity CD-drives for these high-tech assays. I'm not aware of a good review of these experiments, but here are two papers on this subject:
Siyi Lai, Shengnian Wang, Jun Luo, L. James Lee, Shang-Tian Yang, and Marc J. Madou "Design of a Compact Disk-like Microfluidic Platform for Enzyme-Linked Immunosorbent Assay" Analytical Chemistry, 76 (7), 1832 -1837, 2004. doi 10.1021/ac0348322
Horacio Kido, Miodrag Micic, David Smith, Jim Zoval, Jim Norton and Marc Madou "A novel, compact disk-like centrifugal microfluidics system for cell lysis and sample homogenization" Colloids and Surfaces B: Biointerfaces Volume 58, Issue 1, 1 July 2007, Pages 44-51 doi: doi:10.1016/j.colsurfb.2007.03.015 -
Re:Missing the Point
The point is to reduce the overall cost of being capable of running the test, not in vastly increasing the efficiency of running a massive batch of tests this way. Certainly there's downstream potential for it...
Actually there is already research being done in that regard. Some research groups are experimenting with building microfluidic systems on compact-disks. The spinning of the disk generates a centrifugal force that acts as the 'pump' for the device, driving fluid through stages. You can even have special valves in your device, and by changing the rotation speed of the drive, you progressively move the fluid from stage to stage.
Then the CD laser can be used as a detection mechanism at different locations along the disk. Also you can obviously run multiple experiments at once, since as the disk spins the laser passes from one fluid channel to the next.
It's a rather cool idea to use commodity CD-drives for these high-tech assays. I'm not aware of a good review of these experiments, but here are two papers on this subject:
Siyi Lai, Shengnian Wang, Jun Luo, L. James Lee, Shang-Tian Yang, and Marc J. Madou "Design of a Compact Disk-like Microfluidic Platform for Enzyme-Linked Immunosorbent Assay" Analytical Chemistry, 76 (7), 1832 -1837, 2004. doi 10.1021/ac0348322
Horacio Kido, Miodrag Micic, David Smith, Jim Zoval, Jim Norton and Marc Madou "A novel, compact disk-like centrifugal microfluidics system for cell lysis and sample homogenization" Colloids and Surfaces B: Biointerfaces Volume 58, Issue 1, 1 July 2007, Pages 44-51 doi: doi:10.1016/j.colsurfb.2007.03.015 -
Re:Ummm . . .(Sorry to reply to my own post.)
For anyone interested, this argument was made much more clearly than I am able to in a recent Nature review article:
Max Tegmark. "Many lives in many worlds" Nature 448, 23-24 (5 July 2007) | doi:10.1038/448023a; Published online 4 July 2007.
The blurb is:Accepting quantum physics to be universally true, argues Max Tegmark, means that you should also believe in parallel universes.
The article is only available to subscribers, but here are some quotes from the article:The key point is that parallel universes are not a theory in themselves, but a prediction of certain theories. For a theory to be falsifiable, we need not observe and test all its predictions -- one will do.
Because Einstein's general theory of relativity has successfully predicted many things we can observe, we also take seriously its predictions for things we cannot, such as the internal structure of black holes. Analogously, successful predictions by unitary quantum mechanics have made scientists take more seriously its other predictions, including parallel universes. -
Re:Gordon Moore
I'm not sure if this is the same article that you saw previously, but this paper discusses that topic:
Seth Lloyd, "Ultimate physical limits to computation" Nature 406, 1047-1054 (31 August 2000) | doi: 10.1038/35023282 (for those without access to Nature articles, this arXiv preprint appears to be the same article).
The article reviews the absolute maximum limits for computation, based on current understanding of thermodynamics, relativity, and quantum mechanics.
The basic conclusion of the paper is that a theoretical 1 kg computer (confined to a volume of 1 liter), operating perfectly at the edge of what is physically possible could compute 10^51 operations/second on 10^31 bits of information (as compared to our current computers: 10^10 operations/second on 10^10 bits). Naively scaling Moore's law from current sizes, this suggests that we will reach such limits in 250 years. Of course the paper repeatedly points out that this is for an unrealistically 'perfect' computer, that is somehow able to perfectly organize all its internal matter solely for performing the computation at hand. For instance when running a computation it effectively has a temperature of ~10^9 Kelvin, which is considerably hotter than any known material could withstand.
Nevertheless, it's interesting to see what the fundamental principles of relativity and quantum mechanics indicate as a boundary for any sort of computation. The article is an interesting read. -
Price quoted is for commerial use only!
Citation:
Holliday et al. (2007) MACiE (Mechanism, Annotation and Classification in Enzymes): novel tools for searching catalytic mechanisms. Nucleic Acids Research, 35, Database issue D515-D520. DOI linkHe's right that clicking on the right and getting a quick quote for reproducing the entire article as part of a course pack (print and/or electric) is non zero... BUT, producing a course pack doesn't allways equate to non-commerial in my mind.
It might part of university course, in which case Peter Murray-Rust seems justified in taking calling this non-commerial (and therefore free under the CC licence used).
However, the course-pack could be part of a commercial training course for members of the pharma industry - in which case the end user would have to pay the copyright holders.
The bottom of the quick quote page even EXPLAINS this (cropped in his screen shot):
If the item you are seeking permission to re-use is labeled OPEN ACCESS ARTICLE then please note that non-commercial reuse of it is according to the terms and conditions of the Creative Commons license. Permission only needs to be obtained for commercial use and can be done via Rightslink. If you have any queries about re-use of content published as part of the Oxford Open program, please contact journals.permissions@oxfordjournals.org.
What's the big fuss about?
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It Could Be Worse
It is one thing when someone writes a crackpot book with bogus science. What really bothers me is when an executive at a large scientific research company spews nonsense in order to impress investors. Such is the case with Advanced Cell Technology. In this case, Robert Lanza aggressively sends press releases to everyone he knows in the media. The reporters don't bother to fact check properly. He told the press, "We've also tested these cells in animals for the first time, and it turns out that they have incredible reparative potential." The nature methods paper that he is referring to is much less optimistic, "they localized to the site of injury in the damaged vasculature and appeared to participate in repair... Our data suggest that hES-derived blast cells could be important in vascular repair."
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The actual reference...The press release from Georgia Tech has a bit more information. The paper of this work will appear in the October issue of Nature Materials, but is already available online (for subscribers only, unfortunately):
In vivo imaging of hydrogen peroxide with chemiluminescent nanoparticles Dongwon Lee, Sirajud Khaja, Juan C. Velasquez-Castano, Madhuri Dasari, Carrie Sun, John Petros, W. Robert Taylor & Niren Murthy. Published online: 19 August 2007; doi:10.1038/nmat1983
The paper describes the advantages of their nanoparticles:The peroxalate nanoparticles have several attractive properties for in vivo imaging, such as tunable wavelength emission (460-630 nm), nanomolar sensitivity for hydrogen peroxide and excellent specificity for hydrogen peroxide over other reactive oxygen species.
In the paper, they demonstrate the use of this photo-marker in live mice, and are able to image the location of hydrogen peroxide anywhere in the mouse body. An obvious question regarding the technique is the toxicity of the nanoparticles. They do not discuss this in the paper (it will probably be the subject of an upcoming study), but the particles are ester polymers, with embedded dye (a pentacene derivative). So they are not using heavy-metal nanoparticles: these are peroxalate polymers. I'm not an expert in biocompatibility, but from the chemical structure, I wouldn't expect it to be highly toxic (it probably even degrades in the body).
Obviously a detailed toxicity study would be required before use in humans. However it's possible that it could be rapidly adapted to ex-situ diagnostics (e.g. on tissue explants) and then be adapted to live in-situ imaging if/when it is determined to be safe. -
Original article in PLoS Comp. Biol.
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Re:radiation buzz buzz
As others have pointed out, "water resonance" doesn't have much to do with it, and you don't want to match resonance and maximize adsorption: you get a lot of surface heating and nothing reaches the interior. A back of the envelope calculation (or just physics intuition) suggests that to maximize heating all the way through, you want to choose a wavelength that is roughly comparable to the size of the food you're trying to heat (see, e.g., here). 2.45 GHz corresponds to about 12 centimeters.
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Re:Figures
My library has a subscription.
Here's a freely available article that apparently explains the theory. It is cited in an erratum to the original paper. -
Re:Not even close
Also, from the research note, they only simulated a neuron firing rate of 1Hz. I don't know much about mouse brains, but I know that's nowhere near the firing rate found in mammal brains.
Neural activity in human neocortex is actually rather sparse as dictated by limited energy supply. Signals in the brain need to be relayed using sparse neural codes in order to reduce traffic and thus energy usage. In this regard brains can be construed as a communication network, bringing into play information-theoretic concepts, instead of the usual view of the brain as a computational system. See Laughlin & Sejnowski (2003) for an insightful exposition (I thoroughly recommend this article for anyone interested in neuroscience and/or neurobiology).
An average firing rate of 1 Hz per neuron in the human brain might not be that far from the truth. The average firing rate is probably lower in the human brain than in rodent brains. Lennie (2003) has some figures based on realistic neurobiological estimates. -
the actual reference...
There's actually alot of evidence in the literature suggesting that water forms a "structured layer" on hydrophillic (water-compatible) surfaces, and around hydrophillic objects dispersed in water. For instance the mobility of water that structures around proteins has been described in the literature as "ice-like." These measurements are typically based on the density of the water or using things like conductivity to infer mobility.
So the notion of water forming solid-like structures near surfaces is not entirely new. However, direct mechanical measurements of the mobility/viscosity of those last few atomic layers of water are not easy, so this paper certainly adds a valuable contribution to the field.
The actual scientific paper in question can be found here: http://dx.doi.org/10.1103/PhysRevB.75.115415 -
Re:Global warming on Mars, also?Whether you agree with Lindzen or his skeptics, one thing you must conclude from the article is that global climate is still not understood well enough for anyone to make accurate predictions of what will happen in 1 year, 10 years, 100 years. And why "must" we conclude that from the article? It is clear from the article that the role of clouds (which is only one component of many in climate change) is still being seriously debated, for instance. The role of clouds is uncertain, but that doesn't mean that we can't predict anything. Uncertainty in the cloud feedback means that we are uncertain about the climate sensitivity to CO2 emissions, which summarizes the contributions of all the various climate feedbacks. But when you assimilate the observational data, the probable range of climate sensitivity allowed by the data still leads to substantial warming over the next century. And those predictions are always based on models which includes assumptions about how different components of climate change interact. This is non-insightful. All predictions in all fields of science are based on assumptions, but that does not mean that all predictions are worthless — not even when some of the assumptions are inaccurate! As George Box once said, "all models are wrong, but some are useful". Every model makes approximations, and there are always known inaccuracies in any model. The issue is whether current climate models are accurate enough to be useful. On the basis of the physical tests of the assumptions which go into them, and on cross-validation and intermodel comparison studies, I would argue that they are. If you want to argue the opposite, go ahead, but you can't just dismiss them with a trite "they make assumptions". It's much easier to believe information about Mars because the readings are extremely accurate and only come from modern instruments, and we know there is no human influence on temperature. Actually, the temperatures on Mars are known less well than the current temperatures on Earth; it is only as you go further back into the past that the terrestrial uncertainties become greater.
More to the point, however, is that less accurate data on Earth is still better than no data on Mars, which gets back to the 6-year criticism. And most to the point is that the Mars data does not actually establish a causal link between Martian and Earth climate, and there are very good reasons to believe that there is no such link. The only physically possible link is solar output, and changes in solar output are implausible sources of warming both on Mars (here, here) and on Earth (here, here). -
Re:And yetBy the same logic -- Not quite by the same logic. I'm comparing all rail travel against all travel. You're comparing a tiny proportion of road transport against all road transport. You're deliberately choosing a small fraction, I'm deliberately choosing an entire class of transport.
You make a very good point for me though. A transport system is useless if it doesn't go where you want to. For rail, that's about 90% of all travel. And it's not just France, in almost all of the countries, rail makes up only about 10% of all travel.
http://dx.doi.org/10.1787/353365538624
It's an amazingly consistent figure.
So... We want to reduce car usage, reduce energy etc. Rail isn't the answer. -
Re:Not peer reviewed yet...
Er, that's simply not true, it has just been published in a highly prestigious journal (PRL).
http://dx.doi.org/10.1103/PhysRevLett.98.101101
However, IAAC (cosmologist), and despite this being a refereed paper, most of the community aren't taking MOND seriously any more, so I doubt this will garner much attention. The evidence for dark matter is simply too strong. -
Re:Horribly misreported
You're right that we would have just one species of bacteria. We ought to convince ourselves that we do have more than one species, though, and the authors of the article are hard to convince. They use the idea that the incredible diversity and rapid evolution that you mention aren't enough. This indeed relates to the term "evolutionary species."
The authors define "evolutionary species" as a population that evolves independently from others, meaning that genotypes can't cross the line between two evolutionary species. In the term "evolutionary species," I'd put the emphasis on the word species. Yes, all species are evolutionary, but not all evolutionary entities are species.
Why would anyone doubt that asexual organisms can split into evolutionary species? The article says that sexually reproducing organisms can diversify but also experience cohesion within groups, and "asexuals might not diversify into distinct species, because there is no interbreeding to maintain cohesive units above the level of the individual." Distinct is the key word in that sentence. Now, if asexuals have no source of cohesion (including homologous recombination), then they don't have a good way to form truly independent subpopulations, and they can diversify to the extreme, but yes, a group of (true) asexuals would remain always just one big evolutionary species. These authors and others point out that bacteria do form distinct populations (across which genotypes presumably can't cross), but those results are less convincing because the bacteria in question can all undergo recombination, if not sex proper, and that could induce cohesion. The problem of "one big species" still exists for totally asexual organisms like the rotifers in this study.
Figure 2 in the article http://dx.doi.org/10.1371/journal.pbio.0050087 shows all of these ideas about cohesion, species, populations, and so forth relatively elegantly.
In the end, this study shows that the characteristics of some truly asexual critters fit the model of cohesive, independent clusters better than not, and they also fit a model of selection based on more than just geographic isolation, for example. How do they cohere? Probably by ending up in niches, the authors say. It has always made sense that true asexuals could do this, but it sounds like we had little evidence about whether they did in fact, before this paper.
Turning to the Times and Slashdot articles, they are both right to point out that it's interesting that organisms can replicate themselves asexually for so long and still compete with sexual reproducers, but they don't emphasize why that's interesting. The comments are right to point out that both sexual and asexual reproduction can generate diversity, so that's not why asexuals are interesting. They're interesting because they lack the usual source of cohesion and independence. In short, the question was "can organisms diversify and cohere into real species or species-like units without any combining of their genes?" The answer is "it looks like it." As an aside, I have to apply a lot of effort to feel good when all tertiary sources seem to miss subtle points like this all the time. -
Re:Mass transit is useless for 90% of journeysAnd you base this on what, exactly ? Your utter ignorance of any remotely well-implemented public transport systems ?
Nope. Simply the statistics, have you ever investigated them? They're pretty consistent, around 85% to 90% of journeys are made by other means, even with mass transit systems subsidised to the tune of 50% of turnover. There are a couple of exceptions with extremely high density areas, specifically London, Tokyo and New York city centres where it reaches a massive 30% or so of journeys. But for everywhere else, rail is a very bad deal for the population. Hell, it's a bad deal in the high density areas too.
e.g.
http://dx.doi.org/10.1787/353365538624
Basically, our existing mass transit systems, the world over, including Germany, France with "integrated" mass transit systems are essentially expensive white elephants. Generally around 90% of journeys simply cannot be made by rail.
There are physical limitations... The more stations there are, the slower the journey must be, the fewer the stations, the further you have to travel to a station. Trains have to run to a schedule and along a corridor which makes them highly inconvenient when you want to go elsewhere.
Rail just sucks unless you:
A: Happen to live near a station.
B: Want to travel to a point near another station.
And from the stats, around 90% of people don't.
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Re:Oooh! Just like the sexual shrimp inthe print a
Actually, it works! Recently, there was a nice study in the Journal of Experimental Social Psychology on this topic:
Beyond Vicary's fantasies: The impact of subliminal priming and brand choice
Johan C. Karreman, Wolfgang Stroebe and Jasper Claus
Abstract
With his claim to have increased sales of Coca Cola and popcorn in a movie theatre through subliminal messages flashed on the screen, James Vicary raised the possibility of subliminal advertising. Nobody has ever replicated Vicary's findings and his study was a hoax. This article reports two experiments, which assessed whether subliminal priming of a brand name of a drink can affect people's choices for the primed brand, and whether this effect is moderated by individuals' feelings of thirst. Both studies demonstrated that subliminal priming of a brand name of drink (i.e., Lipton Ice) positively affected participants' choice for, and their intention to, drink the primed brand, but only for participants who were thirsty. Theoretical and practical implications of these findings are discussed.
http://dx.doi.org/10.1016/j.jesp.2005.12.002 -
Very interesting.The paper's really interesting, it's currently in press in Current Biology. Abstract:
Although tool use is known to occur in species ranging from naked mole rats to owls, chimpanzees are the most accomplished tool users. The modification and use of tools during hunting, however, is still considered to be a uniquely human trait among primates. Here, we report the first account of habitual tool use during vertebrate hunting by nonhumans. At the Fongoli site in Senegal, we observed ten different chimpanzees use tools to hunt prosimian prey in 22 bouts.
This includes immature chimpanzees and females, members of age-sex classes not normally characterized by extensive hunting behavior. Chimpanzees made 26 different tools, and we were able to recover and analyze 12 of these. Tool construction entailed up to five steps, including trimming the tool tip to a point. Tools were used in the manner of a spear, rather than a probe or rousing tool. This new information on chimpanzee tool use has important implications for the evolution of tool use and construction for hunting in the earliest hominids, especially given our observations that females and immature chimpanzees exhibited this behavior more frequently than adult males.
Should have the DOI 10.1016/j.cub.2006.12.042 when it's published (it's NOT active yet - give it some time).
However, from a quick reading of the paper, this seems to be a simple extension of the ant-nest probing behavior (i.e. jam a stick into a nest and feed off the ants/termites that rush out). What *is* interesting is that the chimps appear to have crafted these tools through a number of steps (which is uncommon, AFAIK, the only other animal to do this is the New Caledonian Crow. -
Mathematical and Computational Modeling
Some of my colleagues (e.g., Vittorio Cristini) have been modeling the potential benefits of nanoparticle drug delivery for a couple of years now. As has been known for some time (e.g., see papers from R.K. Jain), the blood vessels that grow to supply tumors with nutrients (the tumor-induced neo-vasculature) are different than regular, non-pathological vessels. They tend to be more tortuous and leaky, with larger holes than regular vessels.
This is where the nanoparticles come in: one can design nanoparticles that encapsulate cancer drugs in particles that are too large to exit normal blood vessels but can pass through the leakier, tumor-induced blood vessels. This naturally targets cancerous tissues.
However, there are other issues to consider. Due to the high pressure inside tumors (due to the rapid proliferation of cells within a confined area, among other factors), along with the leaky vessels, blood flow can be very poor inside a tumor, and so while the drug may be targeted toward and delivered to the tumor, it may not actually penetrate very far into the tumor. Some great work has been done by Steven McDougall, Sandy Anderson, and Mark Chaplain in this area. In particular, look at their DATIA (dynamic adaptive tumour-induced angiogenesis) papers.
One way around this (suggested by R.K. Jain and Vittorio Cristini, among others) is to use targeted anti-angiogenic therapy to prune out the worse blood vessels and improve flow within the tumors, thereby also improving drug delivery and penetration.
Lastly, on the therapeutic aspect of blocking up tumor blood vessels with the nanoparticles, the work we've done (see this paper, which will appear in the Journal of Theoretical Biology soon), indiscriminately cutting off the nutrient supply to a tumor can increase tumor invasiveness by increasing morphological (shape) instability. (See some of the animations here.) So ironically, while more tumor cells may be killed, those that remain may spread farther and initiate new tumors. Given that hypoxic tumor cells are more likely to be resilient to further treatment (e.g., hypoxic breast cancer cells), this is a problem worth keeping in mind when planning anti-angiogenic therapy.
If you're interested in these topics, please do check out the paper above. (You can also download it at my website without any special memberships.) Even if you don't like it, we have a lot of references you may find handy. -- Paul
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Re:Surely it is time?
I didn't think I had to since those numbers were presented by several different people already and modded highly in this article. Here is one of the pertinent ones that is also well written http://yro.slashdot.org/comments.pl?sid=210866&cid =17175778 [slashdot.org]. Not one person I saw in the entire discussion presented numbers indicating that violent crime (as opposed to "gun crime") correlates favorably with gun control legislation.
Huh? Nothing he mentioned in any way contradicts anything I've said on the matter. The whole thrust of his argument was to put gun related deaths into prospective. I agree, for instance, that the average citizen is far more likely to killed by a car than by a gun. I simply believe that society would be better off if more and better gun laws were put in place (esp. those that would reduce concealed weapons, readily available/loaded weapons, etc).
Several points:
First, the data does not compare gun ownership, frequency of use, and method of use to the deaths and injuries so it tells us little about the risks on a marginal basis. By this same fuzzy rationale I might come to conclude that Russian Rulette is relatively safe because only 3 minors died of it last year (or whatever the exact # would be... certainly very small).
Second, it does not mention any study of correlation of gun ownership in general to any of the various bad things (murder, violent crime, robbery, etc).
Three, it particularly does not discuss specific gun laws as it relates to specific crimes. This is absolutely necessary to persuade me. I believe that responsible ownership of rifles is an acceptable risk generally, but that laws that allow most people to carry and own weapons that are readily concealed (including driving around with a loaded weapon at all times--handgun or not) results in a marginal increase in murders and serious injury (I do not believe that it tends to reduce crime across the board). In other words, even if one were to accept that "gun ownership does not cause an increase in violent crime" this says nothing about particular gun laws, murder rates, etc. That argument is kind of like arguing that, because we can prove that modern medicine correlates strongly with people living longer and healither lives, that any specific doctor or medicine is safe (e.g., untested medicines, unlicensed doctors, etc)."the facts show that there is simply no correlation between gun control laws and murder or suicide rates across a wide spectrum of nations and cultures.
As for these very limited statements you've presented, I disagree with the conclusions you are drawing from them. The mere fact that someone who studied it failed prove correlation in a particular study (or even several) does not mean that there is not a causative impact. There are a lot of other variables involved and the data collection is difficult (different places measure crime and gun ownership different) whether you are comparing two different places or two different times (before and after).
What's more, there are studies that do suggest positive correlation between gun ownership rates and homicide rates...
http://dx.doi.org/10.1016/S1359-1789(03)00044-2
http://dx.doi.org/10.1016/j.aap.2005.02.003
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd= Retrieve&db=PubMed&list_uids=11130511&dopt=Citatio n
http://www.cmaj.ca/cgi/content/abstract/148/10/172 1 -
Re:Surely it is time?
I didn't think I had to since those numbers were presented by several different people already and modded highly in this article. Here is one of the pertinent ones that is also well written http://yro.slashdot.org/comments.pl?sid=210866&cid =17175778 [slashdot.org]. Not one person I saw in the entire discussion presented numbers indicating that violent crime (as opposed to "gun crime") correlates favorably with gun control legislation.
Huh? Nothing he mentioned in any way contradicts anything I've said on the matter. The whole thrust of his argument was to put gun related deaths into prospective. I agree, for instance, that the average citizen is far more likely to killed by a car than by a gun. I simply believe that society would be better off if more and better gun laws were put in place (esp. those that would reduce concealed weapons, readily available/loaded weapons, etc).
Several points:
First, the data does not compare gun ownership, frequency of use, and method of use to the deaths and injuries so it tells us little about the risks on a marginal basis. By this same fuzzy rationale I might come to conclude that Russian Rulette is relatively safe because only 3 minors died of it last year (or whatever the exact # would be... certainly very small).
Second, it does not mention any study of correlation of gun ownership in general to any of the various bad things (murder, violent crime, robbery, etc).
Three, it particularly does not discuss specific gun laws as it relates to specific crimes. This is absolutely necessary to persuade me. I believe that responsible ownership of rifles is an acceptable risk generally, but that laws that allow most people to carry and own weapons that are readily concealed (including driving around with a loaded weapon at all times--handgun or not) results in a marginal increase in murders and serious injury (I do not believe that it tends to reduce crime across the board). In other words, even if one were to accept that "gun ownership does not cause an increase in violent crime" this says nothing about particular gun laws, murder rates, etc. That argument is kind of like arguing that, because we can prove that modern medicine correlates strongly with people living longer and healither lives, that any specific doctor or medicine is safe (e.g., untested medicines, unlicensed doctors, etc)."the facts show that there is simply no correlation between gun control laws and murder or suicide rates across a wide spectrum of nations and cultures.
As for these very limited statements you've presented, I disagree with the conclusions you are drawing from them. The mere fact that someone who studied it failed prove correlation in a particular study (or even several) does not mean that there is not a causative impact. There are a lot of other variables involved and the data collection is difficult (different places measure crime and gun ownership different) whether you are comparing two different places or two different times (before and after).
What's more, there are studies that do suggest positive correlation between gun ownership rates and homicide rates...
http://dx.doi.org/10.1016/S1359-1789(03)00044-2
http://dx.doi.org/10.1016/j.aap.2005.02.003
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd= Retrieve&db=PubMed&list_uids=11130511&dopt=Citatio n
http://www.cmaj.ca/cgi/content/abstract/148/10/172 1 -
Re:umm... BullShit is Bull-Shit is "BULL SHIT"
Anaesthetica has solid bone or rocks for brains
/. - Tell-us-something-we-don't-know.
Anaesthetica should have saved this bullshit for 2007/04/01, or anaesthetica is another one of those ignorant politicians' staffers or lobbyist. If anaesthetica is a staffer or OPEC or AgriBiz lobbyist, then they need to be honest enough to identify themselves as expressing corporatist interest and just spinning-truth to fit lies.
Last I checked, our planet's surface is about two-fucking-thirds water. For our/global economy and environment Hydrogen and SolarCell technology is the only way to solve energy/fuel and air-pollution problems permanently.
I hate stupid staffers, lobbyist, corporatist, and damn fool dogmatist with faux-answers.
http://www.nrel.gov/docs/fy06osti/39936.pdf
Results from the Vehicle/Infrastructure Learning Demonstration Project
http://www.technologyreview.com/read_article.aspx? id=17774&ch=energy
Cheap, Superefficient Solar Solar-power modules that concentrate the power of the sun are becoming more viable.
http://news.com.com/Solar+cell+breaks+efficiency+r ecord/2100-11395_3-6141527.html
Solar cell breaks efficiency record
http://hardware.slashdot.org/hardware/06/12/06/027 228.shtml
http://www.nrel.gov/docs/fy04osti/35174.pdf
Progress in High-Performance PV: Polycrystalline Thin-Film Tandem Cells
http://dx.doi.org/10.1016/S0360-3199(97)00102-X
Affordable hydrogen supply pathways for fuel cell vehicles
http://dx.doi.org/index.html
http://www.greenwatts.com/docs/ProgressInPhotovolt aics.pdf
Energy Pay-Back and Life Cycle CO2 Emissions of the BOS in an Optimized 3.5 MW PV Installation -
Re:umm... BullShit is Bull-Shit is "BULL SHIT"
Anaesthetica has solid bone or rocks for brains
/. - Tell-us-something-we-don't-know.
Anaesthetica should have saved this bullshit for 2007/04/01, or anaesthetica is another one of those ignorant politicians' staffers or lobbyist. If anaesthetica is a staffer or OPEC or AgriBiz lobbyist, then they need to be honest enough to identify themselves as expressing corporatist interest and just spinning-truth to fit lies.
Last I checked, our planet's surface is about two-fucking-thirds water. For our/global economy and environment Hydrogen and SolarCell technology is the only way to solve energy/fuel and air-pollution problems permanently.
I hate stupid staffers, lobbyist, corporatist, and damn fool dogmatist with faux-answers.
http://www.nrel.gov/docs/fy06osti/39936.pdf
Results from the Vehicle/Infrastructure Learning Demonstration Project
http://www.technologyreview.com/read_article.aspx? id=17774&ch=energy
Cheap, Superefficient Solar Solar-power modules that concentrate the power of the sun are becoming more viable.
http://news.com.com/Solar+cell+breaks+efficiency+r ecord/2100-11395_3-6141527.html
Solar cell breaks efficiency record
http://hardware.slashdot.org/hardware/06/12/06/027 228.shtml
http://www.nrel.gov/docs/fy04osti/35174.pdf
Progress in High-Performance PV: Polycrystalline Thin-Film Tandem Cells
http://dx.doi.org/10.1016/S0360-3199(97)00102-X
Affordable hydrogen supply pathways for fuel cell vehicles
http://dx.doi.org/index.html
http://www.greenwatts.com/docs/ProgressInPhotovolt aics.pdf
Energy Pay-Back and Life Cycle CO2 Emissions of the BOS in an Optimized 3.5 MW PV Installation -
Anaesthetica has solid bone for brains
Anaesthetica has solid bone or rocks for brains
/. - Tell-us-something-we-don't-know.
Anaesthetica should have saved this bullshit for 2007/04/01, or anaesthetica is another one of those ignorant politicians' staffers or lobbyist. If anaesthetica is a staffer or OPEC or AgriBiz lobbyist, then they need to be honest enough to identify themselves as expressing corporatist interest and just spinning-truth to fit lies.
Last I checked, our planet's surface is about two-fucking-thirds water. For our/global economy and environment, Hydrogen and SolarCell technology is the only way to solve energy/fuel and air-pollution problems permanently.
I hate stupid staffers, lobbyist, corporatist, and damn fool dogmatist with faux-answers.
http://www.nrel.gov/docs/fy06osti/39936.pdf
Results from the Vehicle/Infrastructure Learning Demonstration Project
http://www.technologyreview.com/read_article.aspx? id=17774&ch=energy
Cheap, Superefficient Solar Solar-power modules that concentrate the power of the sun are becoming more viable.
http://news.com.com/Solar+cell+breaks+efficiency+r ecord/2100-11395_3-6141527.html
Solar cell breaks efficiency record
http://hardware.slashdot.org/hardware/06/12/06/027 228.shtml
http://www.nrel.gov/docs/fy04osti/35174.pdf
Progress in High-Performance PV: Polycrystalline Thin-Film Tandem Cells
http://dx.doi.org/10.1016/S0360-3199(97)00102-X
Affordable hydrogen supply pathways for fuel cell vehicles
http://dx.doi.org/index.html
http://www.greenwatts.com/docs/ProgressInPhotovolt aics.pdf
Energy Pay-Back and Life Cycle CO2 Emissions of the BOS in an Optimized 3.5 MW PV Installation -
Anaesthetica has solid bone for brains
Anaesthetica has solid bone or rocks for brains
/. - Tell-us-something-we-don't-know.
Anaesthetica should have saved this bullshit for 2007/04/01, or anaesthetica is another one of those ignorant politicians' staffers or lobbyist. If anaesthetica is a staffer or OPEC or AgriBiz lobbyist, then they need to be honest enough to identify themselves as expressing corporatist interest and just spinning-truth to fit lies.
Last I checked, our planet's surface is about two-fucking-thirds water. For our/global economy and environment, Hydrogen and SolarCell technology is the only way to solve energy/fuel and air-pollution problems permanently.
I hate stupid staffers, lobbyist, corporatist, and damn fool dogmatist with faux-answers.
http://www.nrel.gov/docs/fy06osti/39936.pdf
Results from the Vehicle/Infrastructure Learning Demonstration Project
http://www.technologyreview.com/read_article.aspx? id=17774&ch=energy
Cheap, Superefficient Solar Solar-power modules that concentrate the power of the sun are becoming more viable.
http://news.com.com/Solar+cell+breaks+efficiency+r ecord/2100-11395_3-6141527.html
Solar cell breaks efficiency record
http://hardware.slashdot.org/hardware/06/12/06/027 228.shtml
http://www.nrel.gov/docs/fy04osti/35174.pdf
Progress in High-Performance PV: Polycrystalline Thin-Film Tandem Cells
http://dx.doi.org/10.1016/S0360-3199(97)00102-X
Affordable hydrogen supply pathways for fuel cell vehicles
http://dx.doi.org/index.html
http://www.greenwatts.com/docs/ProgressInPhotovolt aics.pdf
Energy Pay-Back and Life Cycle CO2 Emissions of the BOS in an Optimized 3.5 MW PV Installation -
Tsunami "expert" Ted Bryant
After RTFA, I found out Ted Bryant is the Tsunami expert in this group of researchers. While researching for my thesis, I was confronted with his book, "Tsunami: the underrated hazard". This work, while being quite easy to understand, can hardly be called scientific based on his way of making citations (grouping all references at the beginning of a chapter which leaves you without the possibility to look up where he drew his conclusions from).
Reviews of his book can be found here: http://hol.sagepub.com/cgi/reprint/12/5/637 and here http://dx.doi.org/10.1016/S0025-3227(03)00086-0 and here: Synolakis, C.E., and G.J. Fryer, 2001. Book Review: Tsunami: the underrated hazard by Edward Bryant, Eos, Trans. Am. Geophys. Union, 82, 588 (can't find a quick link right now).
The existence of so-called megatsunamis is hardly scientifically proven, especially not by the work of Bryant (he classified sedimentary features embedded in sandstone somewhere in Australia as relics of an ancient megatsunami when in a nearby graveyard the same sandstone wouldn't resist local climate and erosion for more than a few centuries).
The propagation of tsunamis with huge waveheights seems to be limited due to dispersion effects and the so-called "Van-Dorn-Effect" should cause these huge waves to break as soon as they reach the continental shelf (http://www.agu.org/pubs/crossref/2005/2004GL02191 8.shtml and http://www.lpl.arizona.edu/~jmelosh/ImpactTsunami. pdf , but also http://www.spaceref.com/news/viewpr.html?pid=10986 ).
After working some time in the field of megatsunamis (my thesis concentrated on the Cumbre Vieja Scenario postulated by Ward&Day back in 2001 (http://www.es.ucsc.edu/~ward/papers/La_Palma_grl. pdf) and, based on scientific grounds, I had to "debunk" it as several researchers have done before me), I have learned to take these reports with a grain (or better, a big portion) of salt. -
900 pages in The Mysterious Future?
FTFA:Journal reference: Proceedings of the National Academy of Sciences (vol 103, p 17979)
But going to the PNAS home page, the largest page number in the current issue (which is v.103) is 17063. Accessing the PNAS Early Edition page and searching for "pain" or "saliva" doesn't turn up anything which seems relevent. So where do I read the original article?
Maybe Newscientist should start using the DOI system so that we can easily resolve and find the original article. -
900 pages in The Mysterious Future?
FTFA:Journal reference: Proceedings of the National Academy of Sciences (vol 103, p 17979)
But going to the PNAS home page, the largest page number in the current issue (which is v.103) is 17063. Accessing the PNAS Early Edition page and searching for "pain" or "saliva" doesn't turn up anything which seems relevent. So where do I read the original article?
Maybe Newscientist should start using the DOI system so that we can easily resolve and find the original article. -
Re:Layman's version of article
And the original research paper can be found at http://dx.doi.org/10.1038/nphys442 (subscription required)
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Superficial analysis of actual article, plus link
First, because I haven't seen anyone point it out yet, the actual journal article is Neurology 2006;67:1208-1214. Go to http://dx.doi.org/10.1212/01.wnl.0000238082.13860
. 50 and the server will redirect you appropriately. The journal's Web site should let you read the abstract for free. To read the whole article, you have to pay, or find a suitable institution with online or print access to this journal.
Now, some comments. The idea that correlation doesn't imply causation is correct, but this paper used a multivariate analysis to attempt to control for several possible confounding factors. I count twelve that the authors thought about and included in some of their models: age, sex, educational level, diabetes, systolic blood pressure, daily alcohol intake, physical activity, perceived health score, perceived stress score, energy, social isolation, and region of residence. It looks like the paper acknowledges more confounders than anyone's mentioned here on Slashdot so far. Ultimately, though, this paper is a cohort study, so you can still argue that they missed a confounding factor. If you can think of a legitimate one, you stand a good chance getting it published in the journal Neurology.
Next, naming intelligent friends with high BMIs or famous thin people with questionable smarts does not change what this paper says, of course. Let's even pretend to add those people to the data. Now we have 2243 subjects instead of 2223. I doubt that changes the results much, but I admit I can't prove that. Counterexamples do tell us something very important, though. If high BMI really causes worse word-list learning, it is still one of a staggering number of other effects on this measure, and it by no means excludes anyone from higher intelligence.
Lastly, people are right to wonder what cognitive tests like word-list learning really measure. This paper didn't use IQ directly, but the point still stands. The authors know this and address it, too. "The functional significance of cognitive changes in our sample is difficult to assess.... We did not collect any direct index of work performance." In fact, they don't know whether differences in these psychometric test scores apply to "this healthy working population." BMI, too, may represent a surrogate marker. The association in this paper still stands, although I don't see anything about whether active weight loss attempts change cognitive point measures or decline. Yes, there are other markers of cardiovascular risk, and these include waist circumference (Am J Cardiol 2006;98:1053-1056), which someone could study in the same way that the Neurology paper studies BMI.
So what's the point? The point is, the differences in these cognitive tests concern some people. The results suggest that some real effect on cognition exists, and the authors mention a few reasonable mechanisms for the effect. If you agree that a normal BMI leads successively to less diabetes, less coronary artery disease, and less chest pain when you walk around, then it makes sense to try for a normal BMI if it's even possible that it will save blood vessels in your brain, or your brain cells directly, or whatever mechanism you believe. It wouldn't surprise me, though, if weight loss merely slows cognitive decline or lessens the risk, rather than positively improving intelligence or some similar claim. The other point is that newspapers check sources and strive to do it very well, but they rarely offer substantial analysis of original research. They will quote authorities regarding the research but leave item-by-item discussion to commentary articles in specialty journals. Even my couple hundred words here only begin to address the reasonable analysis of this or any scholarly article. -
Re:Why Most Published Research Findings Are False
The Ioannidis article you cite has more to do with overinterpretation of statistical power in data analysis than outright falsification of data as in the Poehlman case. In particular, Ioannidis is actually critical of overinterpretation of results obtained from sample sizes that are too small or experimental designs that have too many degrees of freedom. In fact, the title of his study is an overinterpretation of the conclusions in the paper itself - which I'm sure he did on purpose to incite debate on the topic.
This is well summarized in this response to the article, which has the added bonus of quoting "Mudd's Women" to support the argument. -
Re:String Theory really is not falsifiable!!!!
Forgive me for not being up on the details of this, but why do division algebras stop at 8? Does 16 not work?
See Toby Bartels's argument at the bottom of Week 59 of John Baez's TWF series.
Incidentally, the parent poster's argument is wrong. You can construct consistent field theories in N dimensions. Indeed, the division algebras have relevance to why string theory does work in 10 dimensions. (See, for instance, this paper and this comment. -
Some related journal articles
For those with access, anyway. Recent peer-reviewed papers from the group mentioned in the press release Onaran et al, Degertekin et al
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Some related journal articles
For those with access, anyway. Recent peer-reviewed papers from the group mentioned in the press release Onaran et al, Degertekin et al
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The actual scientific paper...The reference for the actual scientific paper in question appears to be:
"Black Holes in Many Dimensions at the CERN Large Hadron Collider: Testing Critical String Theory" JoAnne L. Hewett, Ben Lillie, and Thomas G. Rizzo Phys. Rev. Lett. 95, 261603 (2005) .
For those with access to PRL, the doi for the paper is: 10.1103/PhysRevLett.95.261603
This is the abstract:We consider black hole production at the CERN Large Hadron Collider (LHC) in a generic scenario with many extra dimensions where the standard model fields are confined to a brane. With ~20 dimensions the hierarchy problem is shown to be naturally solved without the need for large compactification radii. We find that in such a scenario the properties of black holes can be used to determine the number of extra dimensions, n. In particular, we demonstrate that measurements of the decay distributions of such black holes at the LHC can determine if n is significantly larger than 6 or 7 with high confidence and thus can probe one of the critical properties of string theory compactifications.
For those without access to PRL, you can view a different version of the manuscript on arXiv.
My comments (with the usual disclaimer: while I am a scientist, I'm not a particle physicist/string theorist, so I would appreciate any corrections to what I say): This work appears significant. String theory is incredibly elegant and fits in very well with other (experimentally verified) theories (quantum field theory, etc.). However, what string theory has always lacked, is experimental backup. The fact that there may be a way to experimentally test one of its predictions/requirements (that of extra dimensions) is truly significant, and will allow these fundamental theories to be advanced way beyond their current speculative nature.
As I understand it, one of the current "problems" in string theory is an over-abundance of theories. There are millions (perhaps even an infinite number) of theory-variants that are all consistent with the current string-theory formalism. Of course only one (or possibly zero) of the theories is right. An experimental test would (I hope!) help pick out which theory variant is the right one... or perhaps tell us that string theory is completely wrong! Either way it's a good thing for science and I look forward to this test being performed at the LHC. -
Re:The wait vs. the cost
How about some facts for that argument on the efficacy of nationalised health care. The numbers are kinda scary.
(disclaimer I'm an Austrlian living in the UK) Here's the thing, Health care is pretty much an actuarial issue with a strong public policy rider. You can work out how much healthcare your society needs as a function of age, nutrition, diet, lifestyle etc of the population, the specific individuals that require that service fall into two clases, those that, by the very nature of their lot in life need more care (the poor probably require more interaction with the service for a wide variety of reasons from nutrition, nature of work, "lifestyle choices") and those who happen to be unlucky enough to need the service, hit by a car, cancer, nasty staf. infection, both present justifcation for why the service is a public good, they did not choose to be where they are and the unsubsidised payment for the service would be unfair when the price had to be borne by the society as a whole anyway, why not let society as a whole pay for it.
The arguments about efficiency are there to be made (and disagreed with) but in my view it is only a technical failing that stops a nationalised health care system from being more efficient than a series of private institutions that must replicate a wide variety of the same services. This is different from other industries because of the nature of healthcare and the "base level" or "capacity" issue highlighted above.