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User: Hoi+Polloi

Hoi+Polloi's activity in the archive.

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Comments · 4,101

  1. MitoSENS on Ask Aubrey de Grey About Longevity Research · · Score: 1
    The MFoundation's website talks about their work on mitochondrial damage alleviation, MitoSENS.

    Only 13 of the mitochondrion's component proteins are still encoded by its own DNA, and it's therefore only these 13 genes that remain vulnerable to the constant assault from free radicals produced during respiration (the life-giving reaction of oxygen and food by the mitochondria).

    If we can incorporate working copies of that mtDNA into our nuclear DNA, the mtDNA will be rendered superfluous and any mutations it suffers will be inconsequential. Researchers have tried to do this for many years, with only limited success.

    So, has this ever been done in any organism in the lab? Is it possible that the remaining mitochondrial genes may need to be physically located in the mitochondria themselves for them to work and/or multiply?

  2. Re:If we stop aging... on Ask Aubrey de Grey About Longevity Research · · Score: 1

    What was the question again?

  3. Re:Dangerous slide on DHS Official Considered Shock Collars For Air Travelers · · Score: 1

    I think you answered your own question. These fearful people don't fly (at least not beyond Orlando or Vegas) and probably don't even own a passport. They are afraid of the unknown. They sit at home being fed disaster shows and fear mongering news and get a hyper paranoid view of the world.

    I frequently have to remind people who, for instance, are obsessed with crime. I ask them "Are there kids being kidnapped in your town? Murders? How much crime do you actually see?". The vast majority of people cannot point at any serious crime. It is all media fed.

  4. Re:What kind of pirates? on G8 Summit Aims To Kill International Piracy · · Score: 1

    First they need to take care of people who copy MS Windows, Whitney Houston songs, etc. Then they'll go after the other pirates with their kidnapping, robbery, murders, etc. They have priorities damnit!

    Maybe they should have the ship kind of pirates go after the internet kind? You download an MP3 and suddenly you hear "Argh matey!" at your door.

  5. Re:Nooo! on Dial-Up Users "Don't Want Broadband" · · Score: 5, Funny

    I hope it stays that way. If it wasn't for the people on slow connections I'd never be able to frag anyone online in a FPS.

  6. Re:Harmonics on Wood Density May Explain Stradivarius Secret · · Score: 4, Funny

    This is all too complicated. I'm just going to wait for "Violin Hero" to come out. The delux package comes with a kettle drum, brass and woodwind section, conductor's baton, etc.

  7. Re:I am far too stupid on Discovery of a "Flat" Atom Hailed as Quantum Computing Breakthrough · · Score: 1

    Thank goodness they finally have flat atoms. All of those bumpy atoms were starting to annoy me.

  8. Re:It's all about ego on Geomicroblogging, Buzzword or Reality? · · Score: 1

    If someone used this word in public I'd assume they were having a fit.

    Bloggers are just taking a page from lazy journalists who stick "gate" at the end of every controversy.

  9. Re:Some data 4 U on OMG Did U C What U R Paying 4 Texting? · · Score: 1

    Duh, of course there are different plans. I meant no competition in the sense that the reciever pays rule applies throughout the US.

  10. Re:Some data 4 U on OMG Did U C What U R Paying 4 Texting? · · Score: 1

    In modern American style, I look forward to running your "Free-range organic chicken" and "Granite countertop" gulags.

    "Comrade, those organic hemp handbags aren't going to make themselves. We have a quota to meet for Urban Outfitters."

  11. Re:Some data 4 U on OMG Did U C What U R Paying 4 Texting? · · Score: 1

    Well, it is partly going here, here, and here.

  12. Re:Some data 4 U on OMG Did U C What U R Paying 4 Texting? · · Score: 1

    But a market economy depends on competition. There is no alternative available to the consumer in this case.

  13. Re:This would be an American article then... on Dead At 92, Business Computing Pioneer David Caminer · · Score: 1

    And even within a country it doesn't stop with Alexander Graham Bell stealing credit from Elisha Gray.

  14. Re:Calling Shenanigans on this Review on Review of Das Keyboard · · Score: 1
    If you don't believe in "keyboard enthusiasts" then clearly you haven't seen this little item.


    Price, approx. $1,864.35

  15. Re:Good. on Intentional GPS Jamming On the Increase · · Score: 1

    Can I add people texting on thier phones to that list? Like the woman I passed on the way home who was drifting out of her lane and jerking it back in suddenly? I didn't see her look up once.

  16. Re:Good. on Intentional GPS Jamming On the Increase · · Score: 4, Informative

    They already do this for the bridges on Storrow Drive that runs along the Charles River in Boston (they would get jammed under the bridge). Problem was that truckers hit it so much they were regularly destroying the sign. You also need to place it in a spot where the truckers can take an exit instead of trying to reverse up a busy road.

  17. Re:Good. on Intentional GPS Jamming On the Increase · · Score: 1

    Why not? We already alter every other law to cater to the "But what about the children!?" crowd at the expense of the freedom of adults or other kids. One kid gets hurt hurt in a playground and before you know it they are only allowed to play with bubble wrap.

  18. Re:Time to look into other means of security on Crooks Nab Citibank ATM Codes, Steal Millions · · Score: 1

    I was fingerprinted for a security clearance while I had bad psoriasis on both hands (it has since cleared up). My fingerprints were just smooth, thickened skin at that point. I pointed this out but they didn't care. I'd love to see the blank prints they got.

  19. Catering Connection? on Google Trends vs. Community Standards On Obscenity · · Score: 1

    Clearly there is a simple connection. People get hungry for desert after their orgy.

  20. Re:And your bad genetics cost ME... on Japan Imposes "Fine On Fat" · · Score: 4, Insightful

    You'll also notice that trying to eat healthy (fresh food, etc) will push your food bill up sharply unless you are willing to eat nothing but oatmeal and beans. I call Whole Foods "Whole Paycheck".

  21. Re:Hang on a minute on Why the LHC Won't Destroy the World · · Score: 2, Insightful

    Based on airplane cockpit recorders (the black boxes) the most likely last word will be "SHIT!".

  22. Re:Not a thief on Confessions of a Wi-Fi Thief · · Score: 1

    Yah, but after all that waterboarding and beatings they don't work too well anymore.

  23. Re:Lawyer: This, boys and girls, is why . . . on Man Fired When Laptop Malware Downloaded Porn · · Score: 1

    All you have to prove is that the accused weighs the same as a duck. Bingo, there is your witch!

  24. Re:Voyeurs - mmmm, exciting! on Guide to DIY Wiretapping · · Score: 1

    When I was a kid the early cordless phones and cellphones could be picked up by the police/air traffic scanners of the day. The conversations were just about that exciting.

    Person 1: I don't have the tickets.
    Person 2: You sure?
    1: Yes
    2: I don't have them.
    1: Can you look on my dresser?
    2: Ok
    1: Find them?
    2: Wait a sec...yah, here they are.
    1: Can you meet me here with them?
    Me: (Sound of scanner being turned off)

  25. Re:voltage drop on Guide to DIY Wiretapping · · Score: 1

    we were all issued with a near perfect bugging device - a butt phone

    You were buggered with a "butt phone"? I hope they didn't bother calling you the next day.