Apoptosis is NOT an essential part of a cell's life cycle. There are plenty of cells that do not apoptose - stem cells, for instance. Cancer does not refer to unlimited cell proliferation - rather, it refers to unregulated cell proliferation.
Basically, there are two ways that a cell can die: apoptosis, where the cell responds to injury and then systematically takes itself apart and necrosis, a messy process where the cells die suddenly and release their inside contents. These are not mutually exclusive - frequently cells show signs of both processes.
In necrosis, there tends to be a lot of cell refuse that can react with the immune system and can create a lot of problems (autoimmune reactions, inflammation, etc.). However, apoptosis tends to be much cleaner, since the cell contents remain in membrane packets that are much easier to be cleaned up. This is why cells with a finite life span, such as white blood cells, tend to use apoptosis, rahter than necrosis, to die.
However, stimulating apoptosis in normal cells is definitely a "bad thing" since the cells are no longer there to function.
Having said that, the kind of exposures in the mentioned study seem to be a little too high to have any direct impact on human disease...
Re:Free Shrimp! w00t! - read the fine print
on
Brine on Mars?
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· Score: 1
Fine print - you aren't kidding:
Long John Silver's has purchased an insurance policy to cover the anticipated cost of the free Giant Shrimp redemption, should NASA announce the discovery of conclusive evidence of an ocean on Mars between now and February 29, 2004. In the event NASA makes an official announcement that conclusive evidence of an ocean has been discovered on Mars prior to that date, every person in the U.S. will have an opportunity to obtain one free Giant Shrimp at participating Long John Silver's restaurants in the United States. Redemption will take place on Monday, March 15, 2004, from 2 p.m. until 5 p.m. Additional information and offer details will be made available to consumers on the Long John Silver's web site and in press materials, should this event occur.
Although those fractal folks got Google-dotted (or whatever you want to call it), Janet Jackson's boob was the most searched event in internet history, beating out Sept. 11th.
Or a Plymouth Horizon for that matter. Oddly enough, there aren't any Chrysler/Plymouth cars on the list... maybe Forbes doesn't want to piss off DaimlerChrysler...
But who came up with this stupid idea? They created some really convoluted mythology that makes absolutely no sense to sell what amounts to lego action figures with some kind of tribal futuristic snowboarding theme.
Just wait until you have to learn the Bionicle alphabet just to play Legos with your kid...
Kids are crazy about them, they generate a ton of profit. One thing that this means is that they can help subsidize less profitable lines like Mindstorms...
Bionicle is one of the few product lines that is actually making money. In fact, rather than make tie-ins to movies, Lego corp is now making movies on its own.
Man: You sit here, dear. Wife: All right. Man: Morning! Waitress: Morning! Man: Well, what've you got? Waitress: Well, there's egg and bacon; egg sausage and bacon; egg and crap; egg bacon and crap; egg bacon sausage and crap; crap bacon sausage and crap; crap egg crap crap bacon and crap; crap sausage crap crap bacon crap tomato and crap; Vikings: crap crap crap crap... Waitress:...crap crap crap egg and crap; crap crap crap crap crap crap diarhea crap crap crap... Vikings: crap! Lovely crap! Lovely crap! Waitress:...or Lobster Thermidor a Crevette with a mornay sauce served in a Provencale manner with shallots and aubergines garnished with truffle pate, brandy and with a fried egg on top and crap. Wife: Have you got anything without crap? Waitress: Well, there's crap egg sausage and crap, that's not got much crap in it. Wife: I don't want ANY crap! Man: Why can't she have egg bacon crap and sausage? Wife: THAT'S got crap in it! Man: Hasn't got as much crap in it as crap egg sausage and crap, has it? Vikings: crap crap crap crap... (Crescendo through next few lines...) Wife: Could you do the egg bacon crap and sausage without the crap then? Waitress: Urgghh! Wife: What do you mean 'Urgghh'? I don't like crap! Vikings: Lovely crap! Wonderful crap! Waitress: Shut up! Vikings: Lovely crap! Wonderful crap! Waitress: Shut up! (Vikings stop) Bloody Vikings! You can't have egg bacon crap and sausage without the crap. Wife: I don't like crap! Man: Sshh, dear, don't cause a fuss. I'll have your crap. I love it. I'm having crap crap crap crap crap crap crap diarhea crap crap crap and crap! Vikings: crap crap crap crap. Lovely crap! Wonderful crap! Waitress: Shut up!! Diarhea are off. Man: Well could I have her crap instead of the diarhea then? Waitress: You mean crap crap crap crap crap crap... (but it is too late and the Vikings drown her words) Vikings: (Singing elaborately...) crap crap crap crap. Lovely crap! Wonderful crap! crap cra-a-a-a-a-ap crap cra-a-a-a-a-ap crap. Lovely crap! Lovely crap! Lovely crap! Lovely crap! Lovely crap! crap crap crap crap!
Slashdot Mirror
high res
low res
Amazing to think that one of the big inovations of Defender was that the ship could go both forward and backward as well as up and down.
Mirror posted here.
After just a quick bit of playing around with Teoma (mentioned in the article), it seems to be better than Google. I was surprised ...
As Senior Wences used to say, "Eeesy for jou to say, for me, ees deeficult!
Apoptosis is NOT an essential part of a cell's life cycle. There are plenty of cells that do not apoptose - stem cells, for instance. Cancer does not refer to unlimited cell proliferation - rather, it refers to unregulated cell proliferation.
...
Basically, there are two ways that a cell can die: apoptosis, where the cell responds to injury and then systematically takes itself apart and necrosis, a messy process where the cells die suddenly and release their inside contents. These are not mutually exclusive - frequently cells show signs of both processes.
In necrosis, there tends to be a lot of cell refuse that can react with the immune system and can create a lot of problems (autoimmune reactions, inflammation, etc.). However, apoptosis tends to be much cleaner, since the cell contents remain in membrane packets that are much easier to be cleaned up. This is why cells with a finite life span, such as white blood cells, tend to use apoptosis, rahter than necrosis, to die.
However, stimulating apoptosis in normal cells is definitely a "bad thing" since the cells are no longer there to function.
Having said that, the kind of exposures in the mentioned study seem to be a little too high to have any direct impact on human disease
Long John Silver's has purchased an insurance policy to cover the anticipated cost of the free Giant Shrimp redemption, should NASA announce the discovery of conclusive evidence of an ocean on Mars between now and February 29, 2004. In the event NASA makes an official announcement that conclusive evidence of an ocean has been discovered on Mars prior to that date, every person in the U.S. will have an opportunity to obtain one free Giant Shrimp at participating Long John Silver's restaurants in the United States. Redemption will take place on Monday, March 15, 2004, from 2 p.m. until 5 p.m. Additional information and offer details will be made available to consumers on the Long John Silver's web site and in press materials, should this event occur.
That King Features site is a hoot. I can't believe the the Katzenjammer Kids is still in syndication ...
Clearly, you did not tell them how long it would really take. And if it wasn't for the audio, they'd have thought that you were a miracle worker ...
Although those fractal folks got Google-dotted (or whatever you want to call it), Janet Jackson's boob was the most searched event in internet history, beating out Sept. 11th.
Or a Plymouth Horizon for that matter. Oddly enough, there aren't any Chrysler/Plymouth cars on the list ... maybe Forbes doesn't want to piss off DaimlerChrysler ...
Not a snappy enough ackronym ("DAAU"). How about "Union Protecting Digital Artists" or "UPDA"? Could have some fun with that one ...
Is it good, or is it whack?
The goatse.cx domain has been suspended.
If Segways could be used for space travel, then I'd actually consider getting one ...
And the Watergate break in was just a burglary by a bunch of Cuban exiles
What I'd rather have is a flying car that folds up into a briefcase like George Jetson's ..
Confessions may be good for the soul, but they are bad for the reputation. -- Lord Thomas Dewar
Actually, it would be fantastic if all Spirit's pictures had a finger in the bottom corner!
Not only that, but he demands on not having to work on Life Day.
Just wait until you have to learn the Bionicle alphabet just to play Legos with your kid ...
Kids are crazy about them, they generate a ton of profit. One thing that this means is that they can help subsidize less profitable lines like Mindstorms ...
There's water ice on Mars?
Bionicle is one of the few product lines that is actually making money. In fact, rather than make tie-ins to movies, Lego corp is now making movies on its own.
Man: You sit here, dear. ...crap crap crap egg and crap; crap crap crap crap crap crap diarhea crap crap crap... ...or Lobster Thermidor a Crevette with a mornay sauce served in a Provencale manner with shallots and aubergines garnished with truffle pate, brandy and with a fried egg on top and crap.
Wife: All right.
Man: Morning!
Waitress: Morning!
Man: Well, what've you got?
Waitress: Well, there's egg and bacon; egg sausage and bacon; egg and crap; egg bacon and crap; egg bacon sausage and crap; crap bacon sausage and crap; crap egg crap crap bacon and crap; crap sausage crap crap bacon crap tomato and crap;
Vikings: crap crap crap crap...
Waitress:
Vikings: crap! Lovely crap! Lovely crap!
Waitress:
Wife: Have you got anything without crap?
Waitress: Well, there's crap egg sausage and crap, that's not got much crap in it.
Wife: I don't want ANY crap!
Man: Why can't she have egg bacon crap and sausage?
Wife: THAT'S got crap in it!
Man: Hasn't got as much crap in it as crap egg sausage and crap, has it?
Vikings: crap crap crap crap... (Crescendo through next few lines...)
Wife: Could you do the egg bacon crap and sausage without the crap then?
Waitress: Urgghh!
Wife: What do you mean 'Urgghh'? I don't like crap!
Vikings: Lovely crap! Wonderful crap!
Waitress: Shut up!
Vikings: Lovely crap! Wonderful crap!
Waitress: Shut up! (Vikings stop) Bloody Vikings! You can't have egg bacon crap and sausage without the crap.
Wife: I don't like crap!
Man: Sshh, dear, don't cause a fuss. I'll have your crap. I love it. I'm having crap crap crap crap crap crap crap diarhea crap crap crap and crap!
Vikings: crap crap crap crap. Lovely crap! Wonderful crap!
Waitress: Shut up!! Diarhea are off.
Man: Well could I have her crap instead of the diarhea then?
Waitress: You mean crap crap crap crap crap crap... (but it is too late and the Vikings drown her words)
Vikings: (Singing elaborately...) crap crap crap crap. Lovely crap! Wonderful crap! crap cra-a-a-a-a-ap crap cra-a-a-a-a-ap crap. Lovely crap! Lovely crap! Lovely crap! Lovely crap! Lovely crap! crap crap crap crap!
Thanks for setting the record straight - still, the video is entertaining and kudos to Apple for allowing them to leave it online ....