It's only one feature of cancerous cells. Another important factor is de-regulation of the cell-cycle by degradation of critical proteins such as p53. If cells can somehow be treated for the other factors involved in cells becoming cancerous, it might be possible that expressing telomerase in all cells could eliminate the aging process. But doing so is extremely difficult and is beyond us. If we could, we would have figured out how to stop another mechanism of cancer progression!:-)
If bone marrow stem cells are also affected by this treatment, you can have problems with production of T-cells (CD4+ and CD8+) and erythrocytes (red blood cells). I wish that they would have at least done tests on other types of human cells. The journal article becomes available April 15th, so we shall see what all the fuss is about.
Inhibiting telomerase has a significant problem: it kills off the gametocytes, which need telomerase to reproduce constantly but still have constant length telomeres. The side effect has to be infertility, unless the researchers found a receptor or variation in cancer cells which allows selective target for the vector. I have a feeling that it is not what they did, since the cancer cells were grown in a tissue culture, and not in vivo. We'll have to wait for human studies to see where this is going.
This mechanism has been studied for a very long time, but this must be the first time that researchers have been successful in manufacturing the vectors.
Of course, there are still promising treatments such as angiogenesis inhibitors which has the benefit of not losing fertility.
There are many shared costs involved: salaries of researchers, replacement equipment, dish-time. However, operating the rovers (both of them) is much more expensive because there is more science being done (cutting open rocks, spectroscopy, moving across the landscape) with the rovers than with the Voyager (sending back occasional data). The Voyager project is obviously less expensive to maintain than the rover projects.
Frankly, Voyager is useless now, and money used to fund that project could be going to more worthwhile projects like the JPL rovers. The Voyager project was never meant to measure data outside of the solar system, but rather to gather data on the gas giants and outer planets. They accomplished that a long time ago.
while at the same time we're dealing with jackasses like you who think we're pretty much the same as janitors.
1. I don't remember the last time I saw a janitor pull a 20 hour day to keep a mission critical component running
2. sorting a terabyte of data into a readable report
3. trying to support ten year old bloatware on a shoestring budget
4. while inventing new tech in their spare time to fill in gaps
You pretty much summed up what janitors do too.
Janitors for restaurants at the busiest times of the year make sure everything is running perfectly for the customers, otherwise the shit would hit the fan. Literally.
Janitors for schools would also have to sort through all the garbage left around to determine what should and shouldn't be thrown out. Have you seen the plumbing in these old watering holes and theaters? Do you know what they have to do to keep those things working and all clean?
You don't think that janitors have to come up with ways to keep things tidy, or bathrooms clean? Do you think that there are little moles that come out at night to clean the place, and magically the whole place is clean by the morning?
Don't get your panties in a bunch. You're not spending 365 days of the year with 20 hour work days. You have hard-pressed time, and you have time to surf slashdot and look at pr0n. Just like how janitors spend some of their time in the basement reading fishing magazines (thank you Dilbert).
IT has changed from implementation to maintenence from the 90s to 2005. Not to be offensive, but when you're maintaining a system or installing updates, or making the network run smoothly, you're nothing more than a lowly technician, someone who has mastered a trade. Rather than bringing forth the unknown as technicians did in the 90s, they are just doing something that someone else doesn't want to spend time doing. When technology was new, there was a mystique in understanding how these computers run. But that mystique is long-gone. Just as in the early days of electricity, it seemed so new to commonfolk, and electricians were seen as magicians for knowing how it worked and how it can be fixed.
If you want more respect for what you do, do something beyond maintaining systems or technician work. Do something that requires intelligence to design the systems. Mystique fades quickly once everyone gets used to the technology and you're not the one propelling it forward.
Administrative Contact: DNS Admin (NIC-1340142) Google Inc. 2400 E. Bayshore Pkwy Mountain View CA 94043 US dns-admin@googledot.org +1.6503300100 Fax- +1.6506181499 Technical Contact, Zone Contact: DNS Admin (NIC-1340144) Google Inc. 2400 E. Bayshore Pkwy Mountain View CA 94043 US dns-admin@googledot.org +1.6503300100 Fax- +1.6506181499
Created on..............: 2005-Mar-15. Expires on..............: 2019-Sep-14. Record last updated on..: 2005-Mar-17 10:42:46.
How would google make money off ads if people pop'ed their mail?
Not many people want to use clunky POP3 anymore when they have the beauty and simplicity of the Gmail interface at their fingertips. Gmail satisfies those who still want POP3 in addition to the interface. Otherwise, what's the point of having a Gmail account?
I actually am a republican, and I would have said the same thing had it been a republican. Everyone knows that democrats are tax and spenders, I just didn't want it to be a part of the important discussion of how serious this internet tax is.
If you know physics and math you can figure out chemistry or biology, but not vice versa.
This is the most bone-headed thing I have ever read on Slashdot. It boggles the mind how stupid this statement is. My head feels like it's going to explode.
Unlike what is suggested by the parent, you don't "pick up" a little bit of molecular biology, or bioinformatics, or computational biology. The focus of your studies should be in studying the biology and then dabbling in a little bit of CS. Hell, I'm doing computational biology research and datamining bacterial genomes, and you hardly even need to know how to develop applications. I've primarily been doing scripting in PERL, and I'm trying to pick up a little python. If you know the fundamentals of programming, you don't even need to take a CS course.
If you're not motivated to do the biology coursework behind bioinformatics, you will not get anywhere in your career. Labs want people who can code a bit, not people who understand the fundamentals of designing operating systems. Mathematics, statistics, and scripting will get you farther than CS and a bit of bio will ever get you. Choose wisely.
Global Cooling will eventually take the place of Global Warming just like the reverse happened in the 70s. When they get more data in the future showing that the Earth is cooling, the theories will switch. Thus, when hell cools down, the global cooling theory will take over for global warming theory.
Derivatives of the PowerPC 970 are being used in the Xbox Next and Project Revolution, Nintendo's successor to the GameCube. A sister processor will also be in Sony's PlayStation 3 system. IBM is currently developing the 970MP, which is due out in the 3rd quarter of 2005, and is code-named "Antares". The PowerPC 970MP is said to be a dual-core processor that can scale up to 3.5GHz. This chip should start at 90nm and then graduate to the 65nm process.
I think we're going Waterworld today. It is "cool" and "pop culture" to say that our esuvees are causing the destruction of the earth, because we all hate the rich people who buy them.
I personally am waiting for the satisfaction of the prediction from the 70s that we're entering a new Ice Age. I want more skiing, damnit!
That actually works pretty well for F11. Not so great for F9 or F10. I think that the gray-out effect and resizing the windows on the fly are hardly supported by the Rage 128. When I click the minimize button to shrink the window, I get the same problem of low frame rates. It's just my video card. Thanks for the shift tip.:-)
But it's too bad that my Voodoo3 card is going unused.:-(
I'm actually quite surprised by its performance in X.3. It performs just like it did when I first got the machine in '99 running OS9. The eye-candy is all there, and simple tasks run really well. It does suffer quite a bit though when trying to use hardware acceleration for anything. The ATi Rage 128 just doesn't cut it for OS X. It never did.
Expose exposing the desktop with two windows open gets probably 1-2 frames per second. When I press F11, I see 1 or 2 frames before the windows disappear.:-( Still, the machine does everything I want it to satisfactorily with 768mb of ram. I'm really considering getting a mini or a laptop and ditching this dinosaur. If I hadn't loved my mac so much, I would have just trashed it and kept using my WinXP box. The beauty of OSX keeps me coming back for more.
Slashdot Mirror
immortality is a feature of cancerous cells
:-)
It's only one feature of cancerous cells. Another important factor is de-regulation of the cell-cycle by degradation of critical proteins such as p53. If cells can somehow be treated for the other factors involved in cells becoming cancerous, it might be possible that expressing telomerase in all cells could eliminate the aging process. But doing so is extremely difficult and is beyond us. If we could, we would have figured out how to stop another mechanism of cancer progression!
If bone marrow stem cells are also affected by this treatment, you can have problems with production of T-cells (CD4+ and CD8+) and erythrocytes (red blood cells). I wish that they would have at least done tests on other types of human cells. The journal article becomes available April 15th, so we shall see what all the fuss is about.
Inhibiting telomerase has a significant problem: it kills off the gametocytes, which need telomerase to reproduce constantly but still have constant length telomeres. The side effect has to be infertility, unless the researchers found a receptor or variation in cancer cells which allows selective target for the vector. I have a feeling that it is not what they did, since the cancer cells were grown in a tissue culture, and not in vivo. We'll have to wait for human studies to see where this is going.
This mechanism has been studied for a very long time, but this must be the first time that researchers have been successful in manufacturing the vectors.
Of course, there are still promising treatments such as angiogenesis inhibitors which has the benefit of not losing fertility.
There are many shared costs involved: salaries of researchers, replacement equipment, dish-time. However, operating the rovers (both of them) is much more expensive because there is more science being done (cutting open rocks, spectroscopy, moving across the landscape) with the rovers than with the Voyager (sending back occasional data). The Voyager project is obviously less expensive to maintain than the rover projects.
Frankly, Voyager is useless now, and money used to fund that project could be going to more worthwhile projects like the JPL rovers. The Voyager project was never meant to measure data outside of the solar system, but rather to gather data on the gas giants and outer planets. They accomplished that a long time ago.
1. I don't remember the last time I saw a janitor pull a 20 hour day to keep a mission critical component running
2. sorting a terabyte of data into a readable report
3. trying to support ten year old bloatware on a shoestring budget
4. while inventing new tech in their spare time to fill in gaps
You pretty much summed up what janitors do too.
Janitors for restaurants at the busiest times of the year make sure everything is running perfectly for the customers, otherwise the shit would hit the fan. Literally.
Janitors for schools would also have to sort through all the garbage left around to determine what should and shouldn't be thrown out. Have you seen the plumbing in these old watering holes and theaters? Do you know what they have to do to keep those things working and all clean? You don't think that janitors have to come up with ways to keep things tidy, or bathrooms clean? Do you think that there are little moles that come out at night to clean the place, and magically the whole place is clean by the morning?
Don't get your panties in a bunch. You're not spending 365 days of the year with 20 hour work days. You have hard-pressed time, and you have time to surf slashdot and look at pr0n. Just like how janitors spend some of their time in the basement reading fishing magazines (thank you Dilbert).
IT has changed from implementation to maintenence from the 90s to 2005. Not to be offensive, but when you're maintaining a system or installing updates, or making the network run smoothly, you're nothing more than a lowly technician, someone who has mastered a trade. Rather than bringing forth the unknown as technicians did in the 90s, they are just doing something that someone else doesn't want to spend time doing. When technology was new, there was a mystique in understanding how these computers run. But that mystique is long-gone. Just as in the early days of electricity, it seemed so new to commonfolk, and electricians were seen as magicians for knowing how it worked and how it can be fixed.
If you want more respect for what you do, do something beyond maintaining systems or technician work. Do something that requires intelligence to design the systems. Mystique fades quickly once everyone gets used to the technology and you're not the one propelling it forward.
Naw. I couldn't bother to read the article either.
Welcome to slashdot. You'll fit in nicely.
That is, encoding English like we encode with a compiler?
OMFG. Liek nevar, j00 n00b. lololol. j/k.
Your mileage may vary....
Your kilometerage may vary?
Damn, I think we're getting re-directs from Googledot.org. Yikes.
Uh oh...
How would google make money off ads if people pop'ed their mail?
Not many people want to use clunky POP3 anymore when they have the beauty and simplicity of the Gmail interface at their fingertips. Gmail satisfies those who still want POP3 in addition to the interface. Otherwise, what's the point of having a Gmail account?
About as well as a Duo of chicks doubling up on a sex-starved /. reader.
kekeke.
I actually am a republican, and I would have said the same thing had it been a republican. Everyone knows that democrats are tax and spenders, I just didn't want it to be a part of the important discussion of how serious this internet tax is.
I'm so sick of hearing about the democrat vs. republican debate. This has to do with over-taxing governments, not politics. Mod parent insightful!
I think we should try to avoid the democrat vs. republican debate and just accept that the government is thinking about taxing the internet.
Discuss.
If you know physics and math you can figure out chemistry or biology, but not vice versa.
This is the most bone-headed thing I have ever read on Slashdot. It boggles the mind how stupid this statement is. My head feels like it's going to explode.
Seriously, get a clue.
Unlike what is suggested by the parent, you don't "pick up" a little bit of molecular biology, or bioinformatics, or computational biology. The focus of your studies should be in studying the biology and then dabbling in a little bit of CS. Hell, I'm doing computational biology research and datamining bacterial genomes, and you hardly even need to know how to develop applications. I've primarily been doing scripting in PERL, and I'm trying to pick up a little python. If you know the fundamentals of programming, you don't even need to take a CS course.
If you're not motivated to do the biology coursework behind bioinformatics, you will not get anywhere in your career. Labs want people who can code a bit, not people who understand the fundamentals of designing operating systems. Mathematics, statistics, and scripting will get you farther than CS and a bit of bio will ever get you. Choose wisely.
All your child are belong to us.
http://www.googlesbitch.com just re-directs to Slashdot.org.
EDIT: It seems that the site is getting slashdotted as we speak.
Global Cooling will eventually take the place of Global Warming just like the reverse happened in the 70s. When they get more data in the future showing that the Earth is cooling, the theories will switch. Thus, when hell cools down, the global cooling theory will take over for global warming theory.
Derivatives of the PowerPC 970 are being used in the Xbox Next and Project Revolution, Nintendo's successor to the GameCube. A sister processor will also be in Sony's PlayStation 3 system. IBM is currently developing the 970MP, which is due out in the 3rd quarter of 2005, and is code-named "Antares". The PowerPC 970MP is said to be a dual-core processor that can scale up to 3.5GHz. This chip should start at 90nm and then graduate to the 65nm process.
I think we're going Waterworld today. It is "cool" and "pop culture" to say that our esuvees are causing the destruction of the earth, because we all hate the rich people who buy them.
I personally am waiting for the satisfaction of the prediction from the 70s that we're entering a new Ice Age. I want more skiing, damnit!
That actually works pretty well for F11. Not so great for F9 or F10. I think that the gray-out effect and resizing the windows on the fly are hardly supported by the Rage 128. When I click the minimize button to shrink the window, I get the same problem of low frame rates. It's just my video card. Thanks for the shift tip. :-)
:-(
But it's too bad that my Voodoo3 card is going unused.
I'm actually quite surprised by its performance in X.3. It performs just like it did when I first got the machine in '99 running OS9. The eye-candy is all there, and simple tasks run really well. It does suffer quite a bit though when trying to use hardware acceleration for anything. The ATi Rage 128 just doesn't cut it for OS X. It never did.
:-( Still, the machine does everything I want it to satisfactorily with 768mb of ram. I'm really considering getting a mini or a laptop and ditching this dinosaur. If I hadn't loved my mac so much, I would have just trashed it and kept using my WinXP box. The beauty of OSX keeps me coming back for more.
Expose exposing the desktop with two windows open gets probably 1-2 frames per second. When I press F11, I see 1 or 2 frames before the windows disappear.