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Download The Human Genome
CMU_Nort writes: "The San Francisco Gate has a story about the completion of the human genome project. Apparently the University of California at Santa Cruz has put the Genome online for downloading here. I don't know about you, but I think this sort of sharing is very cool. We finally have the source for human beings. Now if only they'd GPL it."
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Nicotine free Amish .sig.
The final results of the project which I was talking about (if you actually understood my post) was that if you have a sequence of DNA pairs and put those into a chromosome and put it into an egg cell, you get out a unique individual. For example, here's the beginning of the first sequence on chromosome 21 according to National Institute of Health.
Is that gene the same as my gene? Genes may be different between people right? You just stated it in your post: So that big old file I just downloaded with all the base pairs HAS UNIQUE GENES! It may be different than my genes which means... that that file describes someone other than me. Yes.. in fact it describes a single unique individual (hmm, am I repeating myself from my first post... I THINK I AM!)Well, if nothing else, it should drastically increase the amount of paperwork filled out at spermbanks....
"If one is really a superior person, the fact is likely to leak out without too much assistance" -- John Andrew Holmes
We've got the source code... all we need is a compiler and an O'Reilly book...
-Erik
Frankly, the point is it doesn't matter the race of the people. Only .1% of our DNA codes for _all_ of the attributes that make us different- eye color, skin color, hair color, etc. And we haven't even yet mapped all of these loci.
-bugg
Some ppl out there are just plain stupid. First off, we don't need to GPL it, it's not owned(except, perhaps, by god). Secondly, we have just mapped what amino acids they genes create, and in some cases, what the results are. Thirdly, it's in binary notation!! There are two possible combinations of neucleotides in DNA. To create one particular shade of eye color for example, it would take the setting of millions of genetic 'bits'. And the genome doesn't have a key, so to say. Basically, we are in the cockpit, know where the controls are, but none of them are labeled. So, to do anything useful with this, in your basement laboratories or whatever, it would take several million years. Have fun.
====
Crudely Drawn Games
Copyright, yes. Patent, no.
I'd say if you did the grunt work and figured out the sequence you should be able to charge people for using this information. But if someone else goes ahead and re-does all the work, then you cannot deny them the right to use the results.
Of course, you could get a patent on some specific methods you developed to perform the sequencing and then other people would have to figure out other methods or pay you royalties for your patents.
Mmmm.. Donuts
Who actually owns the gene and information? Could the owner of that actual gene claim a sort of copywrite? Is is possible to copywrite part of your body, albeit very small?
God is horrid about commenting code, apparently ;-)
(So spaketh the agnostic.)
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Am I the only one who thinks Microsoft is a misnomer? Perhaps Macrosoft would be a better fit?
IANAMB (Molecular Biologist) but I believe what they did here was figure out what the individual pieces of the human genome were.
(For lack of the ability to come up with a better analogy) It's like if all cities had the same map, then they discovered the road map of cities. It's what is at each address in the city that makes the cities unique and gives them character. They are just telling you where the houses go, what makes people different is what the houses actually are.
Mmmm.. Donuts
the 24 chromosomes has been online'd by project gutenberg for a while now
-- Kirk S
OTOH your kids are safe, because they are not likely to distribute the "cyb" parts of them, only "org" parts. It's ok to combine non-GPLed stuff with GPL-ed stuff as long as you don't distribute the combination.
But wait...When you...erm...ugh...entertained yourself with your...oh...palm, didn't you actually release your genome to public domain?
Dude, that was hilarious. Thanks for the good laugh.
Mmmm.. Donuts
My understanding is that it's only half that. There are two versions, one with larger files, and one with smaller files in more directories.
--
Marc A. Lepage (aka SEGV)
--
Marc A. Lepage
Software Developer
If He had, it expired some 5740 years ago.
The human genome is only 99% complete. The last 1% will apparently take years. This is due to the method used to discover the genome. In addition, only the composition is known, the function of the genes is far from known for many (I think most) genes.
Still, the sharing is cool.
Lee.
PS I posted this before but with the cookies turned off I came off as a coward... Oh well, that's usually true..
Of course, people actually downloading the whole human genome probable wouldn't worry about this, but couldn't they use a better compression format than .zip? I bet using bzip2 or rar would shave a couple of hundred MBs off of that 753MB file. Also, the differences in compression techniques would be interesting to see on a large group of files mainly consisting of G, A, C, and T.
-- demiurge
You find a file that appears important and obliterate it from memory!!!
Score one for the downtrodden hacker!
They would have to add a new flag and invokacion command like g++ is for using gcc for c++. I guess that would be called using the DNA libraries to link it.
That same invocation (hey, did I spell it right this time?) could be used to compile and link genomes for other organisms like the fruit fly, or anything else we may have mapped, from sources.
Now we just need to right the libraries. Shhh, don't tell anyone that's the hard part.
Ever get the impression that your life would make a good sitcom?
Ever follow this to its logical conclusion: that your life is a sitcom?
"I don't care about the Constitution!" --Bill O'Reilly, November 17, 2009
If anyone tried to licence this, I'd hit 'em with a prior-art based lawsuit, based around the fact that I was using the code long before they licenced it. Of course, people born after it was licenced wouldn't have this option. Of course, I could always just make them pay me royalties...
Keep in mind that there is only a 5% genetic variance between monkeys and humans.
:)
Which means, that unless they checked and double checked this data, if you actually try to compile it into a human, you may end up with a 5-nosed purple haired, blind and deaf armadillo-platypus mix with ESP and a penchant for buggery.
They really do need to GPL this, if for no other reason than for the NO WARRANTY clause.
-- Truth goes out the door when rumor comes innuendo. -- Groucho Marx
for people in australia wanting to have a look
/ 0 /
at this - i've mirrored a copy for download at
ftp://mirror.aarnet.edu.au/pub/genome/15jun2000
http://mirror.aarnet.edu.au/pub/genome/15jun200
-jason
Does anyone know a program that can turn this information into something viewable in linux or, windows even? I wanna see the purdy helix :-P
Actually we can 'compile' the code because we know all the enymnes (polymerases) etc that turn the dna into rna then into proteins, and we know how they work.
So the higher level building block would be the resultant amino acid sequence... Then the functional protein..
'Random' is not a good word to use when talking about genetic material. What influences that decide what information carries on through the generations isn't a result of randomness.. Although base-pair mutations do happen in a generally 'random' way. If a protein is rendered non-functional due to a mutation the other copy of the gene is still functional. Hence non-functional or seeming detrimental genes are carried through time until either they turn out to be an advantage at some point, or a whole new trait emerges. If you study genetics for some time you begin to realize that 'mistakes' or abberations are the pool by which functional innovations occur. Judging genetic fitness on a basically arbitrary basis i.e. anyone saying one trait is the prefered or 'correct' trait are demonstating their misunderstanding how evolution works. There are numerous examples of this. There's the classic sickle-cell enemia example, and those people that carry a defect in a specific protien so the hiv is unable to attach to and infect their cells.. hence, they are immune.
Due to the billions of individuals.. Aside from other factors, randomness occurs within the context of the individual but not within the context of the popluation. Populations and species evolve or remain at a genetic equilibium for very systematic reasons.
We finally have the source for human beings. Now if only they'd GPL it.
Yeah, too bad they didn't comment it.
Where can I get the diffs and patches to assemble my own Cindy Crawford??? If this isn't proof that open source is the best way to date/recreate!
If ya boot up that woman, by golly you're gonna marry her.
___
It's the end of my comment as I know it and I feel fine.
The DNA of a human being is the binary. Source code is normally commented, and that's what they're working out. They've sequenced the genome (== dumped the binary); now they're mapping it (== running a debugger, disassembling, and commenting the source).
Will I retire or break 10K?
There was one poet who patented herself ( I think It was a patent. Could have been a copyright.)
She claimed that she was a unique individual who had spent considerable time and effort 'inventing' herself.
___
It's the end of my comment as I know it and I feel fine.
Not strictly modifies, but creates a derived work, which is the same as modification as far as GPL is concerned.
Hey, this ain't the source, it's the assembly!!! Anybody got the source out there? Preferably with comments?
As we now have Lars from Metallica's DNA (as well as everyone else) we now have prior art and thus the metallica copyright is invalid!!!!!!1
This is a really weird idea, but what if the genome was translated into binary and compiled? There are two base pairs, (AT and GC, for those who didn't pay attention in biology), and binary has 0s and 1s.
If the AT pairs were translated into 1s and the GCs into 0s, and vice versa, we might get some really interesting stuff, or a blue screen (hmm...mayble linux would be better for compiling).
Of course, this same philosophy can be translated into organic computing in the same manner, and genetic code can store data.
If somebody wins a nobel prize for this, remember it was my idea!
Your village called: Their idiot is missing.
Would that mean if I decide to have a kid (thereby utlizing and modifying my genes, and agreeing to the GPL) but then later give the kid up for adoption (redistributing the binary) I'd have to include a full copy of the source code? (Fully sequenced genome for the kid)
:)
That could get expensive!
Best new white rapper since Pimp Daddy Welfare... Pimp-T!
send resumes! :) (sness@sness.net)
look that genome it's mine, look i already have a copy on hand. Now that it is mine i would like a fee paid to me every time you use it.
Does anyone actually have a Java program designed to control air traffic, or for the operation of a nuclear facility?
I would like to ask /. the following:
What research or theory suggests that intelligence is encoded in DNA?
Ok ok ok totally out of context (maybe) but as far as I understand this is assumed, just because there just isn't anything else to account for.
It seems like scientists are trying to decode *everything* from DNA, without thinking of the consequences:
Let's say that you and me are 99.999% genetically indentical (it's maybe even more than that). Could *really* that least digit make us so totally different ??
Does not the fact that humans are so totally influenced by their environment point to that DNA really is not that much acountable for the more "deep" things like thoughts, consciousness and the like.
return -ENOSIG;
Disclaimer: I don't know genetics, and never took biology
It appears to be a matter of taking DNA strands, breaking them up into smaller pieces, getting the individual genomes and then mapping everything back into a picture of the original. I didn't realize it until reading on the site that it's very possible to have read the codes backwards, which makes for an interesting twist on things(No pun intended).
The Human Genome Sequencing Progress page shows that they have 21.1% complete data. I assume this means they are relatively certain everything fit right. (Imagine a puzzle with many pieces that fit in more than one place)
I don't know how long until they get it all, but it seems to be paying off already. Of course, once done, they will have a map for one person, not everyone. (As I understand it)
--Mike--
Although the article doesn't really explain it, what this programmer did was write a contig assembly program -- a program that tries to find the most likely ordering of the fragments in the raw sequence data.
While it is very impressive that a programmer was able to write a contig assembly program in four weeks, and that it only took three days to assemble the entire genome, I really doubt that this particular assembly of the genome is going to be definitive. People like Gene Meyers and Phil Green have devoted years to developing such programs, and I think the results of their programs, although probably taking more than three days to run, are likely to yield more accurate results.
Somewhere I heard that race accounts for less than half of the the genetic difference between two humans, it's only a few genes that make racial differences.
I think some of us finally after laughing loudly at first, then more and more quietly, at joke after stupider joke, are realizing that maybe Slashdot should change. Maybe the Linux community as a whole should change (Linux.com has up stupid polls too, missing a chance at getting actual valuable feedback from the community). Maybe I'm wrong, maybe it's destined to stay the way it is. But if it is to change, that change will be to grow up. Then again.. serious news at Slashdot? Maturity from editors? (besides Jamie, she's the mature one) Maybe not in my lifetime.
Just imagine what microsoft could have instead of that annoying little paper clip!
--
Glenn
HEALTH WARNING:
Glenn
The Smrt way to trade CFDs on the ASX
It is not only: take two people. We share 99% of our genome with apes, about 96 or so with other mammals. So why bother about races... And wasn't it only 85% of the genome they mapped ?
I don't agree with the statement that "we now have the source code for humans". What we seem to have, is a core dump of the "binary", without a dissassembler or any concrete idea of what the higher-level building blocks are. Furthermore, this "binary" has not been produced by a heavenly programmer. Instead, it is the result of a "Genetic Algorithm". If you have ever looked at the results of a genetic algorithm, you would see that they lack any "logical" structure. It is very difficult to see what the code is actually doing, since it hasn't been produced by a logical process, but rather an almost random process over millions of years.
We are working on a writeup page about the technology used for this. It was indeed 100 Linux machines and yesterday the machines running as the web servers pushed out .5 TB of data.
I am surprised I don't see this mentioned anywhere, but the cluster of machines at UCSC that helped crunch the genome were all running Linux.
:-)
It was quite an impressive site when they were all sitting in a lab room with huge window.
If somebody will modify the genome to create a superhuman and then release that superhuman, without also releasing the modifications in source code form, that would violate GPL. (As if anyone will care.)
Why of course they released it so we can generate pads and start off with a wonderfuly large (few hundred megs with the right algs) paddbase. So get crack'n!
... maybe I'm getting them confused with the manual or the warranty.
-- ted russ http://www.arach.net.au/~ted/mydynes/ http://www.arach.net.au/~ted/myblogs/
It was a joke!! "Now if only they'd GPL it" was a poke at the zealots on this site who parrot their little catch phrase without really understanding it. UCSC (go Slugs!!!) is doing us all a great service by actually publishing this stuff.
PS. I go to UCSC if you hadn't noticed.
There comes a time in every man's life when he must say, "No mother! I do not want any more Jell-O!"
I thought it was a joke, personally.
I guess I was in the wrong since both Hrunting and, ATM, +3 moderators agree.
Hmm.
As my father lik@(munch munch)...
Does that mean that if you make kids with this thing, you hace to have them cary their source with them?
But for this blasted dial-up, I would generate my legion of SlashMonkeys!
Maybe I'll just wait until "The Human Genome" comes out on audio-tape so I can hear it recited by James Earl Jones.
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seumas.com
Bruce is joking (he's joking, right?), but the question remains: can people really patent and copyright this kind of stuff (genes, and the like)? I can see how it is valuable intellectual property, so someone is bound to try it, but on the other hand, you don't invent anything, you just discover it.
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Stephen C. VanDahm
with 99% the same genes,
we can start mating with monkeys.
skiy. www.Smokedot.org Drug Info, Rights, Laws, and Discussion
Did you get that joke?
was it funny?
mod it up then.
skiy. www.Smokedot.org Drug Info, Rights, Laws, and Discussion
...go through one article where the god damn GPL ISN'T mentioned???
Okay, so we missed out by 1.6% from being a monkey. As I understand it (I'm definately not a science/biology fellow) we're also something like 95% water. Clouds are 100% water. Did we miss out by 5% from being a cloud?
"Congratulations, Boots. Your robot has become self-aware. You're a daddy now." -- Dr. Rho Bowman
thoughts, consiousness, amd the like are just concepts we humans made up. think about that for a while and your mind will dazzle.
nature vs. nurture is of course a very complicated thing. but i don't think it helps simplifying the argument by saying "well our genes are the same, why aren't we the same". the human genome is just a blueprint. imagine a large building, being built from a blueprint. imagine that happening again. can you honestly say that those two buildings will be exactly the same? no, therefore an identical twin will also not be exactly the same. but they do look alot alike.
do they think alike. most probably not completely, since they're in the same enviroment, and have to somehow find their own niche in that enviroment.
instead, try not to look at differences, but at similarities. although humans seem to behave in a very different way, their individuality arises from minor differences. in essence they are very similar.
so:
1.identical blueprints will not result in the same end product in a natural enviroment
2. humans are very much the same, and not so different as you might think!
ta,
meneer de koekepeer
Go Here and search for "GATTACA".
i've heard of exons, but extrons are a totally new concept to me. tell me what are these special, human specific dna-elements called extrons. apparently an integral part of those dna element one refers to as genes.........
excuse my cynical comment, moderate me to -100 if you wish
meneer de koekepeer
Oh, you were attempting a joke? If not, you better explain what god (no caps) has to do with this. In my , not so humble, opinion this is off-topic.
From what I remember, they can identify bits in the DNA, by sampling identical twins/triplets etc. because they should be quite similiar, they can then compare the DNA and see which bits make us unique.
I am pretty sure that they use this technique as the basis of finding genetic disorders and hereditary disorders etc.
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As cunning as a fox, which has just been appointed professor of cunning at Oxford University. http://www.kinlan.co
i'm not sure, but i don't think that all the software you just mentioned is gpl-ed (as if it matters)
regards,
meneer de koekepeer
The hell we're not. DNA is software. It's a coding scheme for assembling amino acids into a specific sequence to produce proteins. Each amino acid is coded for by a specific three-unit sequence of DNA bases (with some coding redundancy). DNA (more precisely, the information coded by that DNA. The physical DNA is a substrate for the information in exactly the same way that the pits on a CD are a substrate) is a software program that when loaded on to the proper hardware (a cell) will cause that hardware to perform particular functions.
DNA implements a coding scheme just like ASCII or Unicode. It's not an "analogy", it's a fact.
My greatest fear is simply that the genome will be modified at all.
So we should ban evolution altogether, then?
--
WordSocket Voice BBS Software
The latest full release of EMBL (63) weighed in at about 4.7 Gb compressed. This took me about 30 hours to download.
GPL'd tools are available. Checkout EMBOSS for a start, BioPerl, BioJava, bioPython, and BioXML, all linking in with a common biocorba interfaces, and many more besides.
I run my bioinformatics service with a minimum of commercial software (only one commercial package which I am soon replacing with EMBOSS, and several non-open packages. The majority are open to some degree.
Needless to say it is based on Unix systems (IRIX/Linux in my case).
--- Four bases should be enough for any genetic code
Well, placing the human genome online is great. It doesn't make sense to patent a particular gene sequence... so it makes sense that it would be available. What WILL end up getting patented and licensed is PROCESS and METHODS to retrieve, map, and develop derivative drugs from dna. Some interesting stuff is what Protien Design Labs is doing. They *humanize* rodent therapies. I can imagine there are a slew of drugs that work in other species, yet will not work in humans. The ability to takes these and determine possible differences in geneitic components will aid creators of therapies (gene or otherwise).
UG and GM to hold live Internet Conference
I for one am growing more and more disappointed in the way the editors of this website persist in throwing around the 'GPL it' phrase in matters where it's irrelevant.
You guys are trivializing what the GPL represents, and you're bringing ridicule to the community of people who support the GPL for the things it is intended for.
Content can't be 'GPLed' just by putting it out for public access. Books and information can't be 'GPLed' by merely being made freely available for downloading. The GPL describes a development process that involves a robust feedback mechanism for continual development and improvement, not a chunk of boilerplate that merely describes a release of information to the public.
The process that the GNU license encompasses and supports is a development model, not a trivial release method. I would think that Slashdot, more than many other sites online, would recognize this and give the GNU licence and it's advocates the respect they are due.
Please adopt a more decent, respectful attitude toward the GPL. Doing otherwise just waters down it's meaning.
Go ahead and take away 'karma' if this sounds like flamebait. I'm not even the GNU movement's biggest advocate, but this message needs to be said.
... if you can compare the human genome to source code, then the method they used to get the source code is obviously 'reverse engineering', with all the legal implications that has :)
I've often wondered if some of the processing could have been made a distributable project (a la SETI)... it would have been cool to say I contributed to the human genome mapping effort!
A scary thought: my mother could patent her genome, and, since I have my mother's nose, she could charge me royalties for the next 20 years!! :-)
========
Stephen C. VanDahm
My greatest fear is that the genome will be modified to create more zealots for /.. Imagine a race of superhumans capable of posting "Foo should be GPLd" messages as fast as today's trained apes are posting "First Post" messages. There'll be license jokes, insensitive "treat AOL users like dirt" jokes, Microsoft jokes, bad trolls moderated up as funny, good trolls moderated down as flamebait, and flamebait moderated up as insightful. It'll be July 2000 all over again! We must take action to prevent this!
Gates' Law: Every 18 months, the speed of software halves.
Human DNA is roughly a gigabyte. It's interesting that the download, compressed, is also about a gigabyte.
Now we have the object code. Much of the rest of this century will be spent trying to disassemble and comment it.
I was talking to somone, who has been staying up
late hacking perl to make this happen, last
thursday about this and it just is not true thay
are not done. some one in marketing or somthing
just desided to ship now. I am actuly not kidding
what thay rilly have is some sort of plan of how
to finish called the golden path or somthing.
UCSC has been doing lots of good work on this but
the sequencing is not finished from what I here.
Releasing it to SLASHDOT!?!?!
After looking over the kernal source I'm simply terrified what they people here might do with the genome!!
If voting were effective, it would be illegal by now.
Ha! KDE 2.0 is way ahead of the Genome project. Slashdot is sooo biased toward the Genome project it a crime! :-)
Despite it not being complete, the fact that the majority of what is essentially the source code for human beings has been released it fascinating. The day when we could literally look at what makes us 'us' on a computer screen--and meddle with our own genetics--isn't too far off. With this kind of data at your fingertips, and some programs to run DNA combinations, you could imagine 'compiling' a virtual human being within cyberspace.
:)
Who needs avatars when you can upload your genetic code and appear in cyberspace with the same 'realness' as in meatspace?
Are we ready for any of this? Does it matter? Once again, the future is rusing at us, and we have to surf it and ride out the storm as best we can. Hopefully more good will come of the Human Genome Project and it's brethren than ill.
As for GPLing the human genome, I think GOD already hols the patent. When you creat life, license it as you will, for now, I'm accepting the King James Bible as my EULA with God
OTOH, I've always wanted to create life myself...
Beware the Whyte Wolf.
With a gun barrel between your teeth, you speak only in vowels...
Yes.
-------------------------
Stupid people suck.
For most of us it's not a lot of use, I'd agree. Howver, if you're a specialist researcher in numerous biological, medical fields (and possibly anthropology, archeology, geneology and others as well) this stuff is a potential goldmine.
Provided you have the software to mine it of course.
Putting the genome in the public domain is a great start but to make it truly accesable requires freely-availible (i.e. open source / GNU / FSF) tools with which to explore it. Otherwise, as you observed, it's pretty difficult to follow.
My guess is that if those tools appear then one day not too far away kids in highschool will do lab exercises in biology class that involve cloning genes and so forth(*). That may seem far-fetched but I suspect that we're witnessing a nascient technological revolution at about the stage that the current "computer revolution" was in when a bunch of geeks were doing apparently pointless things with the original Altair.
* If OS/GNU tools don't turn up most schools aren't going to be able to afford the tools - so no labwork.
[ Blairism is the continuation of Thatcherism by other means. ]
Under the Universal Copyright Convention (Berne), a copyright notice is not required. As most nations are members of either or both the UCC and WTO (which requires adherence to the UCC), there are only a handful of nations on Earth where a copyright notice can possibly be required, and in few of those is there any actual recognition of copyrights at all.
Steven E. Ehrbar
There is no http://genome.ucsc.edu/robots.txt. And we are talking of an enormous database.
You'd better keep your robots off the site.
__
__
Men with no respect for life must never be allowed to control the ultimate instruments of death.
GW Bu
Damn, where are my moderation points when I need them... :)
"Reactionaries must be deprived of the right to voice their opinions; only the people have that right." - Mao
Having gone to Santa Cruz, it doesn't surprise me that they would be so willing to publish educational/scientific material online. It makes me proud to have been a banana slug (mascot of UCSC).
The results may not be the definitive work, but it is definitely a huge leap in the right direction. I really wouldn't be surprised if we hear more from the bio-chem labs there soon.
- I don't need to go outside, my CRT tan'll do me just fine.
If anything it should be entirely Public Domain.
At least that's my opinion...
Actually, this was a joke. I'm a Gnome user.
Otherwise, I agree that the "GPL it" phrase is overused. People need to understand the reasons for why the GPL came about (ie. freedom) and apply those *ideals* to items other than software rather than just slapping a "GPL" label on them.
<B>30 Ways to be Offensive at a Funeral</B>
<OL>
<LI>Tell the widow that the deceased's last wish was that she make love with you.
<LI>Tell the undertaker that he can't close the coffin until you find your contact lens.
<LI>Punch the body and tell people that he hit you first.
<LI>Tell the widow that you're the deceasd's gay lover.
<LI>Ask someone to take a snapshot of you shaking hands with the deceased.
<LI>At the cemetery, play taps on a kazoo.
<LI>Walk around telling people that you've seen the will and they're not in it.
<LI>Ask the widow to give you a kiss.
<LI>Drive behind the widow's limo and keep honking your horn.
<LI>Tell the undertaker that your dog just died and ask if he can sneak him into the coffin.
<LI>Put a hard-boiled egg in the mouth of the deceased.
<LI>Slip a whoopee cushion under the widow.
<LI>Leave some phony dog poop on top of the deceased.
<LI>Tell the widow that you have to leave early and ask if the will can be read before the funeral is over.
<LI>Urge the widow to give the deceased's wooden leg to someone poor who can't afford firewood.
<LI>Walk around telling people that the deceased didn't like them.
<LI>Use the deceased's tongue to lick a stamp.
<LI>Ask the widow for money which the deceased owes you.
<LI>Take up a collection to pay off the deceased' gambling debts.
<LI>Ask the widow if you can have the body to practice tattooing on.
<LI>Put crazy Glue on the deceased's lips just before the widow's last kiss.
<LI>Show up at the funeral services in a clown suit.
<LI>If the widow cries, blow a trumpet every time she wipes her nose.
<LI>When no-one's looking, slip plastic vampire-teeth into the deceased's mouth.
<LI>Toss a handful of cooked rice on the deceased and scream "MAGGOTS! MAGGOTS!" and pretend to faint.
<LI>At the cemetary take bets on how long it takes a body to decompose.
<LI>Goose the widow as she bends over to throw dirt on the coffin.
<LI>Circulate a petition to have the body stuffed instead of buried.
<LI>Tell everyone you're from the IRS and you're confiscating the coffin for back-taxes.
<LI>Promise the minister a hundred dollars if he doesn't keep a straight face while praising the deceased.
</OL>
<BR>
It already can, you just need to know the right flags to compile it with.
B AD_MATRIX_RIP-OFFISH_TYPE_OF_WAY genome.txt -o ai
/home directory once you're done with it. And have you ever tried to potty train a computer program? Let me tell you, when it dumps it's core, it's not a pretty sight.)
gcc --WITHOUT_THE_NEED_TO_ENSLAVE_HUMANITY_IN_A_VERY_
Also, you might want to check on any child processes spawned by your new program. If they get bad, you'll have to spank them manually.
_jeremy
(incidentally, you may wish to give it it's own
Now they can assemble their very own Natalie Portmans(Portmen?) from common household items like hot grits and raw potatoes!
Banned from moderation 01-27-2002. Fuck you too
Truly impressive when one realises that the compressed files alone weigh-in at just a bit over 1500 MBs. Has anyone actually downloaded and unzipped the files? I'm not looking for laughs or a troll here, but I'm honestly curious just how much data is in a genome... a viable storage medium, perhaps? I'm serious.
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Am I the only one who thinks Microsoft is a misnomer? Perhaps Macrosoft would be a better fit?
God only holds the patent if he/she/it exists and that may be very difficult to prove in a patent court.
To complicate matters, if one religion's deity does exist then presumably the rest of the divine menagerie exists as well - so then we have to wait until the gang finishes duking it out and decide which one of them has to take responsibility for cocking up and creating the human race.
Even after that there remains the problem that the deity who takes the rap for the humanity would have to fight various corporations through the courts and legislature for the rights to the genome. Unless he/she/it has been doling out a lot more soft money in Washington DC than appears to b the case recently they are going to loose that one.
[ Blairism is the continuation of Thatcherism by other means. ]
Genbank & Pubmed rock my world....even if a lot of the genbank stuff is crap.
Scuttlemonkey is a troll
So when will gcc be able to compile the source into a working AI? I suppose that such an AI would have terrible social skills as it wouldn't have been brought up in a normal environment.
Nice! I was praying they'd make it available for download! Now if I could just get this darn DNA replicator to boot up...
Yeah, that would give a whole new meaning to the expression "GPL virus". I can already picture it:
I create virus, GPL it's DNA, and then release it. You get the virus, get contaminated, and now you are required to release your DNA specs for everyone to see! Yeah! Go, GPL, go!
(8-DCS)
Bruce
Bruce Perens.
It's all public domain now.
My mom is not a Karma whore!
Since everyone's DNA is different, how do we determine which part is what makes us unique, which part is changable (to a certain extent to make us humans "compatible") and which part is disposable DNA? Was the genome a replica of a caucasian, asian, black, or a bit of each?
Go get your free Palm V (25 referrals needed only!)
Is that even possible?
So how long until someone writes mod_human for apache?
Although the benefits of embedding a human in your web server are dubious.
--------- Beware the dragon, for you are crunchy and good with ketchup.
As soon as I heared, I downloaded the whole thing, and did this, but it didnt work! tar xzvf genome.tar.gz man/arms.c // written in C! man/legs.c man/brain.h ... and so on ./configure --with-bigboobs it seemed to work, and then: make woman but nothing happens! anyone can help???
That's not the half of it. Think of whatt they'll do when they find out your doing cellular mitosis without extra genome licences!
- Sig
No, it's more like 80% water.
Which is amusing because the surface of the Earth is about 75% water. Maybe if I pee a lot, I can become a planet!
race accounts for less than half of the the genetic difference
Isn't that what you'd expect? In fact, I'd be rather surprised if it was anywhere close to half.
Not only can the races interbreed with complete success, there are morons and geniuses, weaklings and strong men, over roughly the same large spread in each race. To me these facts alone suggest that there should be far greater diversity within races than between them.
However, I don't take this to mean that racial differences are necessarily insignificant or uninteresting, though one should naturally expect all but the most blatantly obvious to be lost in the variety of individuals.
But isn't the genome the complete set of genes for the species? Not the genes of one man, but the total genetic catalog of all mankind? If so, the question "Which man?" (to which you replied) is nonsensical.
4.5 hrs, to be exact, and that's on a cable modem....Has anyone else finished d/l'ing it and taken a look at it?
Writhe your naked ass to the mindless groove.
http://www.jackiereaper.com
>My greatest fear isn't that someone will modify
>the genome to create a superhuman and then not
>tell anyone
the gpl fixes this.
I thought my genome had a lifetime warranty. If it completely failed, I could come in for an exchange.
Fight Spammers!
I'm not looking to troll here, but, honestly, what possible reason, (besides being able to bring a chick over to your house and say 'hey baby, wanna see my source code?') would anybody have to download 1500 megs? I dug around the site, and I found a sample of what is contained in those mammoth files; you can check out what's contained within the zips here .
Again, I'm not looking to troll here -- I'm just curious, that's all. =)
Wow - The whole blueprint for a human being (approx. 750MB) almost fits on a CD-ROM. My Mandrake distro came on 6 CD-ROMs.
Then again, I didn't have to feed the distro and wait twenty years for it to grow into something useful. The difference is the genome encodes the potential whereas the distro encodes the actuality.
[ Blairism is the continuation of Thatcherism by other means. ]
If I GPL my genes, then later, my children want to become cyborgs, would they be violating the license if they were to use implants that weren't GPL'd?
Would I be better off releasing my genes under the LGPL?
'Tis a razors edge between Flaimbait and Funny.
There are a TON of freely available bioinformatics type programs available, a good start is to browse Biocat. Of course to get any use out of these programs you should have some knowledge of biology & computational biology. Traditionally academic software is very open, though not GPL (I'm beginning to hate all you GPL-wanting whining fuckers (this is not necessarily directed to the poster I am replying to)). An unfortunate trend as of late is servers which provide an application but no binaries to run locally, and no code. Not very scientific if you ask me. Also not helped by the GPL.
one day not too far away kids in highschool will do lab exercises in biology class that involve cloning genes and so forth
In high school I took Advanced Placement Biology (suppose to be equiv to an intro college course) and one of the labs was to introduce a plasmid into E. Coli so that it became immune to ampicyllin, an anti-biotic. Genetic experiments are definitely possible at the high school level, it's just a matter of getting the expensive machines and specialized knowledge. Maybe a schoold district could put its money into a couple PCR machines and a knowledgable lab tech?
Scuttlemonkey is a troll
I didn't download the whole thing as it'd take over 5 hrs, but I determied that the compression ratio is about 75%, so it should be about 3 GB umcompressed, and is probably a text file consisting of A,G,C,Ts.
Now if only they'd GPL it.
Geezus, why does everything have to be related to open-source software? We're not dealing with software here, folks, no matter how many analogies you want to make.
Guess what, the human genome is better than GPL'd. It's completely free. If you alter it, you have a copy of the new code right in the genes. We did majority of the work on decoding the genome in the last 2 years. Decoding is practically trivial now, and the finished product carries with it the code that made it.
Everything is not software, and not everything should live by the rules of software. I personally would love to stop hearing talk about licenses with respect to the human genome and start hearing talk about the responsible use of the code. My greatest fear isn't that someone will modify the genome to create a superhuman and then not tell anyone what they did. My greatest fear is simply that the genome will be modified at all.
There's a fine line between advocacy and zealotry
I talked with a molecular biologist on this issue and apparently the human genome is 99% done but the last 1% should take years to find. This is because of the method used to find it. In addition, note that the genome is only structurally identified, it is still unclear exactly what each part influences.
In any case, the sharing is cool!
Are they accepting diffs?
"Consider yourself a member of a virtual corporation with Mr. Torvalds as your Chief Executive Officer." - Linux Advocac
I'm donwloading sequences (human included) since 1994 from NCBI web site (http://www.ncbi.nlm.nih.gov/).
I'm working on sequence analysis to make philogenetic trees in Quilmes University (Argentina).
DNA in your Linux: DNALinux
Since the UC Santa Cruz team considers this a "rough draft" of the human genome, it seems like they are in need of contributors. Just send in a single hair or a few drops of blood.
Here's the chance for everyone, even the script kiddies, to contribute to a future open source project. No coding experience or 'leet skilz' are required. (sorry, me english->leetspeek translator is down)
---
Interested in the Colorado Lottery?
Interested in the Colorado Lottery or Powerball games?
check out http://colotto.com
Note: Don't think that if i receive a "Cease and desist" letter from Him, i'm going to stop using my genes....
You're not MEEPT. You don't seem very glorious, and you didn't make me laugh. I also don't see a sig about bringing together all the divided factions of /. into one big divided faction, so you must be fake. MEEPT is dead! Long live the MEEPT!
Scuttlemonkey is a troll
I've said it before, I'll say it again, riflip mapping is bunk.
This so-called "genome" is a VERY rough aproximation of a subset of human DNA.
Have you ever wondered where the restriction enzymes come from? Go look it up.
What we need is a decompiler, not munged binaries.
--Charlie
I had no idea that Sony or Columbia Pictures had these kind of connections...
Fight Spammers!
Uh, wouldn't we need God's permission first?
Ever get the impression that your life would make a good sitcom?
Ever follow this to its logical conclusion: that your life is a sitcom?
"I don't care about the Constitution!" --Bill O'Reilly, November 17, 2009
Quick download the human genome and spread it around the internet before the RIAA and MPAA try to stop links to it. Humans duplicate copyrighted material. These agencies do not want the information required to build a human to be available.
We must stop them from eliminating humans in the name of greed.
There is also a rumour that they are attempting to patent sex.
134340: I am not a number. I am a free planet!